CN102308444B - 利用高速光学波长调谐源的设备和方法 - Google Patents
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Abstract
本发明可以提供用于例如提供高速波长调谐的设备、源装置和方法的示例性实施例。根据一个示例性实施例,可以提供至少一种装置,该装置被配置为发射电磁辐射,所述电磁辐射具有这样的频谱:(i)平均频率以大于约每毫秒6000(或2000)太拉赫兹的绝对速率变化,(ii)平均频率在大于约10太拉赫兹的范围上变化,和/或(iii)具有小于约15千兆赫的瞬时线宽。根据另一个示例性实施例,可以提供至少一种装置,该装置被配置为基于至少一个第一电磁辐射的平均频率而根据时间周期性地来选择至少一个第一电磁辐射,其中周期性地选择以第一特征周期执行。平均频率可以随时间线性变化,其中所述设备可以发射至少一个第二电磁辐射,该第二电磁辐射具有平均频率以第二特征周期根据时间周期性地变化的频谱。此外,第一特征周期可以大于第二特征周期。
Description
相关申请的交叉参考
本申请基于并要求2009年2月4日提交的美国专利申请序列号61/149,922的优先权的权益,其全部公开内容作为参考并入本文。
技术领域
本公开的示例性实施例通常涉及光学***,并且更具体地涉及用于波长调谐的光学波长滤波器***和方法以及能够利用所述光学波长滤波器***的波长扫描激光器装置和方法。
背景技术
为了开发用于光学反射技术、生物医学成像、传感器探询、测试以及测量的波长可快速和宽范围地调谐的激光源而付出了相当大的努力。通过使用腔内窄带波长扫描滤波器获得了窄线宽、宽范围和快速的调谐。通过使用衍射光栅滤波器装置在扩展腔半导体激光器中提供了无跳模、单频率工作。然而,为了获得单频率的激光器工作并且为了确保无跳模调谐,传统技术可能需要使用复杂的机械设备并且限制最大调谐速度。一个经论证的使用传统***的最大调谐速度被限制为小于100nm/s。在一些应用中,例如在生物医学成像中,对应于大于等于10GHz的瞬时线宽的多纵模工作可能是足够的。这种宽度可以在光学相干断层扫描技术中提供对组织的数毫米的测距深度并且在光谱编码的共焦显微术中提供微米级横向分辨率(transverse resolution)。
通过使用腔内调谐元件(例如,声光滤波器、法布里-珀罗滤波器和检流计驱动的衍射光栅滤波器)可获得大约10GHz级的线宽。然而,之前提供的扫频小于约1kHz并被滤波器的有限调谐速度限制。对于生物医学应用中的视频速率(例如,大于30帧/秒)、高分辨率光学成像可能需要具有重复速率大于15kHz的更高速的调谐。
此外,说明了可以使用多边形扫描滤波器的波长扫描激光器,并且该激光器可以提供达到约10000nm/ms的高速波长调谐。尽管基于高速多边形的波长扫描光源促进了快达约200帧/s的高速成像、快达约10000nm/ms的波长调谐速率,但维持瞬时线宽窄于0.15nm仍达到了当前基于多边形的波长扫描滤波器的极限。
事实上,本公开的示例性实施例的一个目的是减少或解决本文以上说明的现有技术的程序和***的缺陷和/或限制。例如,关于更快速的调谐、在快速调谐速率下的宽波长调谐范围和窄瞬时线宽,可能需要波长扫描滤波器装置和程序(例如,激光器程序)的示例性实施例。
发明内容
本公开的示例性实施例涉及用于光波滤波的可以提供具有宽光谱调谐范围和窄瞬时线宽的高速波长扫描光的设备、源装置和方法。在本公开的一个示例性实施例中,示例性的高速波长扫描激光器能够包括可以使用多边形扫描镜的高精度波长调谐滤波器、具有半导体光学放大器(SOA)增益介质的短长度激光器谐振器、时间交织光学延迟线和/或升压光学放大器,上述装置例如在所述源的输出端口处。一些示例性光学组件和示例性装置以及短长度激光器腔可以促进在宽调谐范围上的窄瞬时线宽的高速波长扫描。在一个示例性配置中,可以获得大于约41000nm/ms的波长变化率同时具有窄于约0.2nm的瞬时线宽。示例性的激光器谐振器可以包括例如具有特别设计的半导体光学增益介质的单向环或线性腔,从而最大化所述增益并且最小化所述激光腔的腔长度。
因此,可以提供根据本公开的设备的一个示例性实施例。在本示例性实施例中,可以提供至少一种装置,该装置被配置为发射电磁辐射。这种示例性辐射可以具有平均频率这样变化的的频谱:(i)以大于约每毫秒6000太拉赫兹的绝对速率变化,以及(ii)在大于约10太拉赫兹的范围上变化。
例如,所述平均频率可以在大于5千赫的重复速率下反复变化。所述频谱可以具有中心大致集中在1300nm的调谐范围。所述频谱可以具有小于100千兆赫、或者甚至小于35千兆赫的瞬时线宽。可以提供多边形装置该多边形装置可以被配置为接收与发射的电磁辐射相关联的至少一个信号,并且将所述信号反射和/或偏转到另一位置。此外,可以提供激光器谐振***,该***可以形成光学电路并且被配置为控制发射的电磁辐射的空间模式。所述示例性设备可以使发射的电磁辐射在所述激光器谐振***的至少一部分内基本单向地传播。
可以提供根据本公开的设备的另一个示例性实施例。在本示例性实施例中,还可以提供至少一种装置,该装置被配置为发射电磁辐射。这种示例性的辐射可以具有(i)平均频率以大于约每毫秒2000太拉赫兹的绝对速率变化的频谱,以及(ii)小于约15千兆赫的瞬时线宽。
根据再一个示例性实施例,可以提供至少一种装置,该装置被配置为基于至少一个第一电磁辐射的平均频率而根据时间周期性地来选择所述至少一个第一电磁辐射,其中周期性选择以第一特征周期执行。所述平均频率可以随时间线性变化,其中所述设备可以发射至少一个第二电磁辐射,该第二电磁辐射具有平均频率以第二特征周期根据时间周期性地变化的频谱。此外,所述第一特征周期可以大于所述第二特征周期。
例如,所述第一特征周期可以是所述第二特征周期的至少两倍。所述第二电磁辐射可以具有平均频率以大于约每毫秒2000太拉赫兹的绝对速率变化的频谱。所述第二电磁辐射还可以具有小于约15千兆赫的瞬时线宽。
根据本公开的另一个示例性实施例,可以提供一种设备。该示例性设备可以包括至少一种装置,该装置可以被配置为基于第一电磁辐射的平均频率选择所述至少一个第一电磁辐射。所述选择可以由该装置在第一特征自由光谱范围内装置执行。例如,所述设备可以发射至少一个第二电磁辐射,该第二电磁辐射可以具有平均频率在第二特征自由光谱范围内根据时间周期性地变化的频谱。所述第一特征自由光谱范围可以大于所述第二特征自由光谱范围。
根据本公开的一个示例性变型,所述第一特征周期可以是所述第二特征周期的至少两倍。所述第二电磁辐射可以具有平均频率以大于约每毫秒2000太拉赫兹的绝对速率变化的频谱。所述第二电磁辐射还可以具有小于约15千兆赫的瞬时线宽。所述平均频率可以随时间线性变化。
在再一个示例性实施例中,可以提供一种设备。该示例性设备可以包括至少一种装置,该装置被配置为基于第一电磁辐射的平均频率而根据时间周期性地来选择至少一个所述第一电磁辐射。周期性选择可以以第一特征周期执行。所述示例性设备还可以被配置为发射至少一个第二电磁辐射,该第二电磁辐射具有平均频率在第二特征周期中根据时间周期性地变化的频谱。例如,所述第一特征周期可以大于所述第二特征周期的持续时间的两倍。
本公开的示例性实施例的这些和其他目的、特征和优点将基于结合所附权利要求阅读以下本公开的示例性实施例的详细说明而变得显然。
附图说明
本公开的进一步的目的、特征和优点将通过以下结合示出了本公开的说明性实施例的附图的详细说明而变得显然,在附图中:
图1是根据本公开的具有单向环谐振器的高速波长扫描激光器***/装置的第一示例性实施例的示意图;
图2是说明了根据本公开的一个示例性实施例的时间交织光学延迟线和升压放大器的示例性使用的组合的功能框图;
图3(a)是根据本公开的时间交织纤维延迟线的一个示例性实施例的图示,所述时间交织纤维延迟线具有用于复制和粘贴激光器输出的级联的马赫-曾德尔(Mach-Zehnder)干涉计。
图3(b)是根据本公开的时间交织纤维延迟线的另一个示例性实施例的图示,所述时间交织纤维延迟线具有树形纤维延迟,该树形纤维延迟具有用于复制和粘贴激光器输出的法拉第旋转镜;
图4是根据本公开的具有单向环谐振器的高速波长扫描激光器***/装置的第二示例性实施例的示意图。
图5是根据本公开的具有线性腔谐振器的高速波长扫描激光器***/装置的第三实施例的示意图;以及
图6是根据本公开的具有线性腔谐振器的高速波长扫描激光器***/装置的第四示例性实施例的示意图。
在全部附图中,除非另有声明,否则相同的参考标记和字符用于表示所说明的实施例中的相同的特征、元件、组件或部分。此外,虽然现在将参考附图详细说明主题公开,但这是结合说明性实施例完成的。其意图在于可以在不背离由所附权利要求限定的主题公开的实质范围和精神的情况下对所说明的示例性实施例进行改变和改进。
具体实施方式
图1示出了根据本公开的高速波长扫描激光器***/装置的示例性实施例的示意图。例如,示例性激光器***/装置可以包括能够利用多边形扫描镜700的光学高精度波长调谐滤波器1’、短长度单向环谐振腔2’以及具有升压光学放大器500的时间交织光学延迟线400。示例性的光学波长调谐滤波器1’可以配置为能够具有基本相似或相同的输入和输出端口的反射型滤波器。示例性的波长调谐滤波器1’可以包括衍射光栅220、具有一组透镜260和262的望远镜、多边形扫描镜700和末端反射器280和282。
根据本公开的示例性实施例的波长调谐程序的示例性实施方式可以与之前的方法(见Oh,Optics Letters 30(23),3159-3161(2005)的说明书和国际专利公开WO 2005/001401的公开内容)类似,所述之前的方法包括在用于大锐度(finesse)滤波器的多边形镜上的四次反射(2次×双通)的示例性程序,但不具有根据本公开的示例性实施例的折叠望远镜,从而减小光学路径长度。在传统方法中,具有许多面的多边形扫描镜可以用于增大调谐重复速率。虽然增加所述面的数量可以帮助增大调谐重复速率,但这可能不是增大具有给定滤波器带宽的波长扫描速率的最有效的方式,所述最有效的方式的特征可以在于每单位时间的总波长扫描范围和滤波器通带的单位宽度。
例如,对于固定的滤波器带宽,多边形扫描滤波器的精度可以与N2成反比,其中(FSR)和(δλ)3dB分别是滤波器的自由光谱范围和3dB的带宽,D是多边形的直径并且N是多边形的面的数量。因此,波长扫描速率可以大致变为与1/N成正比。对于以N=128提供115kHz调谐重复速率(9200nm/ms)的传统的基于多边形的波长扫描激光器,例如,如果使用N=28的多边形镜700,则可以获得约41800nm/ms的波长扫描速率。根据本公开的示例性实施例,可以使用约为25kHz的调谐重复速率。然而,FSR(其确定波长调谐范围)可能变为约1664nm。
当激光器腔中的增益支持发射超过104nm带宽的激光时,可以获得具有约6.25%的占空比322的超过约104nm的连续波长扫描。之后,示例性的激光输出的空闲部分可以通过制作激光输出的15个副本、恰当的延迟和以时间交织光学延迟线400粘贴而被完全填充,从而在多边形700的单个面至面旋转周期中产生例如约16次波长扫描。因此,可以获得约400kHz(25kHz×16)的重复速率。延迟线400的输出可以使用升压放大器500放大。
当波长扫描速率很高时,减小激光器腔的光学路径长度可能变得重要。例如,为了通过减小每个腔往返行程的滤波器中心波长偏移而支持内腔光子长寿命,通过使用用于望远镜(例如,透镜)260,262的短焦距透镜可以减小和/或最小化激光器谐振器的长度。在环形腔2’中,促进单向激光发射的绝缘体可以被集成在半导体光学放大器(SOA)增益介质100的内部,并且SOA 100的尾纤120,122可以在端部/连接器140,142处被再次连接(re-connetorized),由此使得光学纤维的长度最小。为了形成环形振荡,多边形滤波器的输出可以被垂直偏置并且通过反射器200引导向SOA 100的输入连接器142。以下本文将说明图1示出的示例性实施例的额外组件及其示例性工作。
图2示出了根据本公开的示例性实施例的组合的功能框图,该图说明了时间交织光学延迟线和升压放大器的示例性使用。例如,激光器输出246可以直接自多边形滤波器820提供,例如,在本示例性情况下,所述多边形滤波器820可以具有约25%的占空比。该输出的三个副本可以在244处被引导和制作,恰当地延迟,并且之后通过时间交织延迟线400粘贴840。之后激光器输出功率600可以通过升压放大500被恢复860。
图3(a)和3(b)示出了根据本公开的伴随用于复制和粘贴激光器输出的光学纤维的时间交织光学延迟线的示例性实施例。例如,为了制作三个副本,可以利用三个不同长度的纤维延迟442,444和446。这些示例性的延迟副本可以通过使用如图3(a)的示例性实施例中所示的级联的马赫-曾德尔干涉计(其还说明了***器420,422,424的使用以及线402上提供的输出)被粘贴到原始激光器输出246。还可以利用具有循环器403、***器421,423,425和法拉第旋转镜460,462,464和466的树形干涉计,从而减小或消除延迟线中的双折射效应,如图3(b)的示例性实施例中所示。
图4示出了根据本公开的高速波长扫描激光器***/装置的第二示例性实施例的示意图。使用这种示例性实施例,可以在SOA(例如,增益介质)100之后获得激光器腔的输出并且通过自由空间输出射束***器240。由于滤波后的光320在点300处耦合之前可以通过SOA 100放大,因此来自腔302的输出光可以在输出的空闲部分期间包含例如特定量的振幅自发发射(amplitude spontaneous emission,以下简记为ASE)。为了避免或减小这种ASE与延迟线/装置400中的复制的激光器输出重叠,在激光器谐振器输出的空闲周期中,SOA增益介质100可以在点102处被调制为断开。
图5示出了根据本发明的具有示例性线性腔配置的高速波长扫描激光器***/装置的第三示例性实施例的示意图。例如,具有反射镜涂层122的SOA增益介质110可以被提供在所述***/装置的一端上,所述***/装置可以支持激光器装置的线性腔振荡。来自激光器的振荡器的输出可以通过自由空间光学射束***器240被耦合。
图6示出了根据本公开的具有线性腔配置的高速波长扫描激光器***/装置的第四示例性实施例的示意图。在本示例性实施例中,具有局部反射涂层124的SOA增益介质112可以被提供在示例性***/装置的一端上,所述***/装置可以支持激光器的线性腔振荡以及通过局部反射器124被发射的光。这种SOA增益介质112可以被耦合为激光器输出,并且引导光可以被引导244到光学延迟线400。激光器谐振器输出的空闲部分中的ASE可以通过SOA 112的增益开关102被减小和/或消除。
前述部分仅说明了本发明的原理。在考虑到本文的教导的情况下,对所说明的实施例的各种改进和变更对本领域技术人员来说将是显然的。事实上,根据本公开的示例性实施例的装置、***和方法可以用于任何OCT***、OFDI***、SD-OCT***或其他成像***和/或实现任意这些***,以及用于例如于2005年5月26日以国际专利公布号WO 2005/047813公布的2004年9月8日提交的国际专利申请PCT/US2004/029148、于2006年5月4日以美国专利公布号2006/0093276公布的2005年11月2日提交的美国专利申请No.11/266,779、于2005年1月27日以美国专利公布号2005/0018201公布的2004年7月9日提交的美国专利申请No.10/501,276以及于2002年5月9日公布的美国专利公布第2002/0122246号中说明的那些***,这些专利申请的公开内容以其整体作为参考并入本文。因此,将要理解本领域技术人员将能够设计尽管未在本文中明确示出或说明但体现了本发明的原理而因此在本公开的精神和范围内的多种***、装置和方法。此外,就现有技术的知识未明确地作为参考在以上并入本文来说,所述现有技术的知识以其整体被明确地并入本文。本文以上引用的全部出版物以其整体作为参考并入本文。
Claims (22)
1.一种利用高速光学波长调谐源的设备,包括:
至少一种装置,该装置被配置为发射具有这样的频谱的电磁辐射,所述频谱的平均频率(i)以大于每毫秒6000太拉赫兹的绝对速率变化,以及(ii)在大于10太拉赫兹的范围上变化,其中,所述至少一种装置包括进一步的装置,所述进一步的装置被配置为接收与发射的电磁辐射相关联的至少一个信号,并且对所述至少一个信号执行反射或偏转中的至少一个以达到另一位置。
2.根据权利要求1所述的设备,其中所述平均频率以大于5千赫的重复速率反复变化。
3.根据权利要求2所述的设备,其中所述频谱具有中心集中在1300nm的调谐范围。
4.根据权利要求2所述的设备,其中所述频谱具有小于100千兆赫的瞬时线宽。
5.根据权利要求2所述的设备,其中所述频谱具有小于35千兆赫的瞬时线宽。
6.根据权利要求1所述的设备,其中至少一种所述进一步的装置包括多边形装置。
7.根据权利要求1所述的设备,进一步包括激光器谐振***,该激光器谐振***形成光学电路并且被配置为控制发射的电磁辐射的空间模式。
8.根据权利要求7所述的设备,其中所述设备使发射的电磁辐射在所述激光器谐振***的至少一部分内基本单向地传播。
9.一种利用高速光学波长调谐源的设备,包括:
一种装置,该装置被配置为发射电磁辐射,该电磁辐射具有(i)平均频率以大于每毫秒2000太拉赫兹的绝对速率变化的频谱,以及(ii)小于15千兆赫的瞬时线宽,其中,所述装置包括进一步的装置,所述进一步的装置被配置为接收与发射的电磁辐射相关联的至少一个信号,并且对所述至少一个信号执行反射或偏转中的至少一个以达到另一位置。
10.根据权利要求9所述的设备,其中所述进一步的装置包括多边形装置。
11.根据权利要求9所述的设备,进一步包括激光器谐振***,该激光器谐振***形成光学电路并且被配置为控制发射的电磁辐射的空间模式。
12.根据权利要求11所述的设备,其中所述设备使发射的电磁辐射在所述激光器谐振***的至少一部分内基本单向地传播。
13.一种利用高速光学波长调谐源的设备,包括:
至少一种装置,该装置被配置为基于至少一个第一电磁辐射的平均频率而根据时间周期性地来选择所述至少一个第一电磁辐射,其中周期性地选择以第一特征周期执行,
其中所述平均频率随时间线性变化,
其中所述设备被配置为发射至少一个第二电磁辐射,该第二电磁辐射具有平均频率以第二特征周期根据时间周期性地变化的频谱,
其中所述第一特征周期大于所述第二特征周期,以及
其中所述至少一种装置包括进一步的装置,所述进一步的装置被配置为接收与发射的电磁辐射相关联的至少一个信号,并且对所述至少一个信号执行反射或偏转中的至少一个以达到另一位置。
14.根据权利要求13所述的设备,其中所述第一特征周期是所述第二特征周期的至少两倍。
15.根据权利要求13所述的设备,其中所述至少一个第二电磁辐射具有平均频率以大于每毫秒2000太拉赫兹的绝对速率变化的频谱。
16.根据权利要求15所述的设备,其中所述至少一个第二电磁辐射具有小于15千兆赫的瞬时线宽。
17.一种利用高速光学波长调谐源的设备,包括:
至少一种装置,该装置被配置为基于至少一个第一电磁辐射的平均频率选择所述至少一个第一电磁辐射,所述选择由所述至少一种装置在第一特征自由光谱范围内执行,
其中所述设备发射至少一个第二电磁辐射,该第二电磁辐射具有平均频率在第二特征自由光谱范围内根据时间周期性地变化的频谱,
其中所述第一特征自由光谱范围大于所述第二特征自由光谱范围,以及
其中所述至少一种装置包括进一步的装置,所述进一步的装置被配置为接收与发射的第一电磁辐射或发射的第二电磁辐射中的至少一个相关联的至少一个信号,并且对所述至少一个信号执行反射或偏转中的至少一个以达到另一位置。
18.根据权利要求17所述的设备,其中所述第一特征周期是所述第二特征周期的至少两倍。
19.根据权利要求17所述的设备,其中所述至少一个第二电磁辐射具有平均频率以大于每毫秒2000太拉赫兹的绝对速率变化的频谱。
20.根据权利要求19所述的设备,其中所述至少一个第二电磁辐射具有小于15千兆赫的瞬时线宽。
21.根据权利要求17所述的设备,其中所述平均频率随时间线性变化。
22.一种利用高速光学波长调谐源的设备,包括:
至少一种装置,该装置被配置为基于至少一个第一电磁辐射的平均频率而根据时间周期性地来选择所述至少一个第一电磁辐射,周期性地选择以第一特征周期执行,
其中所述设备被配置为发射至少一个第二电磁辐射,该第二电磁辐射具有平均频率以第二特征周期根据时间周期性地变化的频谱,
其中所述第一特征周期大于所述第二特征周期的持续时间的两倍,以及
其中所述至少一种装置包括进一步的装置,所述进一步的装置被配置为接收与发射的第一电磁辐射或发射的第二电磁辐射中的至少一个相关联的至少一个信号,并且对所述至少一个信号执行反射或偏转中的至少一个以达到另一位置。
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Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9164240B2 (en) | 2011-03-31 | 2015-10-20 | Lightlab Imaging, Inc. | Optical buffering methods, apparatus, and systems for increasing the repetition rate of tunable light sources |
ES2544034T3 (es) | 2011-09-05 | 2015-08-27 | ALLTEC Angewandte Laserlicht Technologie Gesellschaft mit beschränkter Haftung | Aparato de marcado con al menos un láser de gas y un termodisipador |
ES2544269T3 (es) * | 2011-09-05 | 2015-08-28 | ALLTEC Angewandte Laserlicht Technologie Gesellschaft mit beschränkter Haftung | Aparato de marcado con una pluralidad de láseres de gas con tubos de resonancia y medios de deflexión ajustables individualmente |
DK2565994T3 (en) | 2011-09-05 | 2014-03-10 | Alltec Angewandte Laserlicht Technologie Gmbh | Laser device and method for marking an object |
EP2565996B1 (en) | 2011-09-05 | 2013-12-11 | ALLTEC Angewandte Laserlicht Technologie Gesellschaft mit beschränkter Haftung | Laser device with a laser unit, and a fluid container for a cooling means of said laser unit |
ES2530070T3 (es) * | 2011-09-05 | 2015-02-26 | ALLTEC Angewandte Laserlicht Technologie Gesellschaft mit beschränkter Haftung | Aparato de marcado con una pluralidad de láseres y conjuntos ajustables individualmente de medios de desviación |
EP2564972B1 (en) * | 2011-09-05 | 2015-08-26 | ALLTEC Angewandte Laserlicht Technologie Gesellschaft mit beschränkter Haftung | Marking apparatus with a plurality of lasers, deflection means and telescopic means for each laser beam |
DK2564973T3 (en) * | 2011-09-05 | 2015-01-12 | Alltec Angewandte Laserlicht Technologie Ges Mit Beschränkter Haftung | Marking apparatus having a plurality of lasers and a kombineringsafbøjningsindretning |
ES2438751T3 (es) | 2011-09-05 | 2014-01-20 | ALLTEC Angewandte Laserlicht Technologie Gesellschaft mit beschränkter Haftung | Dispositivo y procedimiento para marcar un objeto por medio de un rayo láser |
JP2015502562A (ja) * | 2011-10-18 | 2015-01-22 | ザ ジェネラル ホスピタル コーポレイション | 再循環光学遅延を生成および/または提供するための装置および方法 |
JP2016507892A (ja) * | 2012-12-21 | 2016-03-10 | デイビッド ウェルフォード, | 光の波長放出を狭幅化するためのシステムおよび方法 |
KR20150054542A (ko) * | 2013-11-12 | 2015-05-20 | 삼성전자주식회사 | 광대역 파장 가변광원 시스템 및 이를 적용한 장치 |
US10281391B2 (en) * | 2015-06-05 | 2019-05-07 | Luminit Llc | Spectrally pure short-pulse laser |
US10542961B2 (en) | 2015-06-15 | 2020-01-28 | The Research Foundation For The State University Of New York | System and method for infrasonic cardiac monitoring |
JP6477611B2 (ja) | 2015-08-21 | 2019-03-06 | 株式会社デンソー | ターミナルインサート品 |
AU2017382218B2 (en) | 2016-12-21 | 2023-05-11 | Acucela Inc. | Miniaturized mobile, low cost optical coherence tomography system for home based ophthalmic applications |
CN112638233B (zh) | 2018-06-20 | 2024-06-14 | 奥克塞拉有限公司 | 基于家庭的眼科应用的微型移动低成本光学相干断层扫描*** |
WO2021134087A1 (en) | 2019-12-26 | 2021-07-01 | Acucela Inc. | Optical coherence tomography patient alignment system for home based ophthalmic applications |
EP3916365A1 (en) * | 2020-05-25 | 2021-12-01 | Aragon Photonics Labs, S.L.U. | Method and system for interrogating optical fibers |
US10959613B1 (en) | 2020-08-04 | 2021-03-30 | Acucela Inc. | Scan pattern and signal processing for optical coherence tomography |
CN116390683A (zh) | 2020-08-14 | 2023-07-04 | 奥克塞拉有限公司 | 用于光学相干断层扫描a扫描去弯曲的***和方法 |
US11393094B2 (en) | 2020-09-11 | 2022-07-19 | Acucela Inc. | Artificial intelligence for evaluation of optical coherence tomography images |
AU2021352417A1 (en) | 2020-09-30 | 2023-04-06 | Acucela Inc. | Myopia prediction, diagnosis, planning, and monitoring device |
JP2024511085A (ja) | 2021-03-24 | 2024-03-12 | アキュセラ インコーポレイテッド | 軸長測定モニタ |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1077046A (zh) * | 1991-12-30 | 1993-10-06 | 菲利浦电子有限公司 | 光学装置和包含该装置的对信息面扫描的设备 |
Family Cites Families (484)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2339754A (en) * | 1941-03-04 | 1944-01-25 | Westinghouse Electric & Mfg Co | Supervisory apparatus |
GB1257778A (zh) | 1967-12-07 | 1971-12-22 | ||
US3601480A (en) | 1968-07-10 | 1971-08-24 | Physics Int Co | Optical tunnel high-speed camera system |
JPS4932484U (zh) | 1972-06-19 | 1974-03-20 | ||
JPS4987350A (zh) * | 1972-12-22 | 1974-08-21 | ||
FR2253410A5 (zh) | 1973-12-03 | 1975-06-27 | Inst Nat Sante Rech Med | |
US3941121A (en) | 1974-12-20 | 1976-03-02 | The University Of Cincinnati | Focusing fiber-optic needle endoscope |
US3983507A (en) | 1975-01-06 | 1976-09-28 | Research Corporation | Tunable laser systems and method |
US3973219A (en) | 1975-04-24 | 1976-08-03 | Cornell Research Foundation, Inc. | Very rapidly tuned cw dye laser |
US4141362A (en) | 1977-05-23 | 1979-02-27 | Richard Wolf Gmbh | Laser endoscope |
GB2030313A (en) | 1978-06-29 | 1980-04-02 | Wolf Gmbh Richard | Endoscopes |
FR2448728A1 (fr) | 1979-02-07 | 1980-09-05 | Thomson Csf | Dispositif joint tournant pour liaison par conducteurs optiques et systeme comportant un tel dispositif |
US4295738A (en) | 1979-08-30 | 1981-10-20 | United Technologies Corporation | Fiber optic strain sensor |
US4300816A (en) | 1979-08-30 | 1981-11-17 | United Technologies Corporation | Wide band multicore optical fiber |
US4428643A (en) | 1981-04-08 | 1984-01-31 | Xerox Corporation | Optical scanning system with wavelength shift correction |
US5065331A (en) | 1981-05-18 | 1991-11-12 | Vachon Reginald I | Apparatus and method for determining the stress and strain in pipes, pressure vessels, structural members and other deformable bodies |
GB2106736B (en) | 1981-09-03 | 1985-06-12 | Standard Telephones Cables Ltd | Optical transmission system |
US4479499A (en) | 1982-01-29 | 1984-10-30 | Alfano Robert R | Method and apparatus for detecting the presence of caries in teeth using visible light |
US5302025A (en) * | 1982-08-06 | 1994-04-12 | Kleinerman Marcos Y | Optical systems for sensing temperature and other physical parameters |
US4601036A (en) | 1982-09-30 | 1986-07-15 | Honeywell Inc. | Rapidly tunable laser |
HU187188B (en) | 1982-11-25 | 1985-11-28 | Koezponti Elelmiszeripari | Device for generating radiation of controllable spectral structure |
CH663466A5 (fr) | 1983-09-12 | 1987-12-15 | Battelle Memorial Institute | Procede et dispositif pour determiner la position d'un objet par rapport a une reference. |
US4639999A (en) * | 1984-11-02 | 1987-02-03 | Xerox Corporation | High resolution, high efficiency I.R. LED printing array fabrication method |
US4763977A (en) | 1985-01-09 | 1988-08-16 | Canadian Patents And Development Limited-Societe | Optical fiber coupler with tunable coupling ratio and method of making |
US5318024A (en) | 1985-03-22 | 1994-06-07 | Massachusetts Institute Of Technology | Laser endoscope for spectroscopic imaging |
EP0590268B1 (en) | 1985-03-22 | 1998-07-01 | Massachusetts Institute Of Technology | Fiber Optic Probe System for Spectrally Diagnosing Tissue |
US4734578A (en) * | 1985-03-27 | 1988-03-29 | Olympus Optical Co., Ltd. | Two-dimensional scanning photo-electric microscope |
US4607622A (en) | 1985-04-11 | 1986-08-26 | Charles D. Fritch | Fiber optic ocular endoscope |
US4631498A (en) | 1985-04-26 | 1986-12-23 | Hewlett-Packard Company | CW Laser wavemeter/frequency locking technique |
JPS62188001U (zh) | 1986-05-20 | 1987-11-30 | ||
US5040889A (en) | 1986-05-30 | 1991-08-20 | Pacific Scientific Company | Spectrometer with combined visible and ultraviolet sample illumination |
CA1290019C (en) | 1986-06-20 | 1991-10-01 | Hideo Kuwahara | Dual balanced optical signal receiver |
US4770492A (en) | 1986-10-28 | 1988-09-13 | Spectran Corporation | Pressure or strain sensitive optical fiber |
JPH0774861B2 (ja) * | 1987-04-06 | 1995-08-09 | 日本電信電話株式会社 | 光パルス多重化回路 |
GB2209221B (en) | 1987-09-01 | 1991-10-23 | Litton Systems Inc | Hydrophone demodulator circuit and method |
US5202931A (en) * | 1987-10-06 | 1993-04-13 | Cell Analysis Systems, Inc. | Methods and apparatus for the quantitation of nuclear protein |
US4892406A (en) | 1988-01-11 | 1990-01-09 | United Technologies Corporation | Method of and arrangement for measuring vibrations |
FR2626367B1 (fr) | 1988-01-25 | 1990-05-11 | Thomson Csf | Capteur de temperature multipoints a fibre optique |
FR2626383B1 (fr) | 1988-01-27 | 1991-10-25 | Commissariat Energie Atomique | Procede de microscopie optique confocale a balayage et en profondeur de champ etendue et dispositifs pour la mise en oeuvre du procede |
US4925302A (en) * | 1988-04-13 | 1990-05-15 | Hewlett-Packard Company | Frequency locking device |
DE68929553T2 (de) * | 1988-07-13 | 2009-01-29 | Optiscan Pty. Ltd., Toorak | Konfokales Rastermikroskop |
GB8817672D0 (en) | 1988-07-25 | 1988-09-01 | Sira Ltd | Optical apparatus |
US4868834A (en) | 1988-09-14 | 1989-09-19 | The United States Of America As Represented By The Secretary Of The Army | System for rapidly tuning a low pressure pulsed laser |
DE3833602A1 (de) * | 1988-10-03 | 1990-02-15 | Krupp Gmbh | Spektrometer zur gleichzeitigen intensitaetsmessung in verschiedenen spektralbereichen |
US4940328A (en) | 1988-11-04 | 1990-07-10 | Georgia Tech Research Corporation | Optical sensing apparatus and method |
US4966589A (en) | 1988-11-14 | 1990-10-30 | Hemedix International, Inc. | Intravenous catheter placement device |
ATE133545T1 (de) * | 1988-12-21 | 1996-02-15 | Massachusetts Inst Technology | Verfahren für laserinduzierte fluoreszenz von gewebe |
US5046501A (en) | 1989-01-18 | 1991-09-10 | Wayne State University | Atherosclerotic identification |
US5317389A (en) * | 1989-06-12 | 1994-05-31 | California Institute Of Technology | Method and apparatus for white-light dispersed-fringe interferometric measurement of corneal topography |
US4965599A (en) | 1989-11-13 | 1990-10-23 | Eastman Kodak Company | Scanning apparatus for halftone image screen writing |
US4984888A (en) * | 1989-12-13 | 1991-01-15 | Imo Industries, Inc. | Two-dimensional spectrometer |
US5251009A (en) | 1990-01-22 | 1993-10-05 | Ciba-Geigy Corporation | Interferometric measuring arrangement for refractive index measurements in capillary tubes |
DD293205B5 (de) | 1990-03-05 | 1995-06-29 | Zeiss Carl Jena Gmbh | Lichtleiterfuehrung fuer ein medizinisches Beobachtungsgeraet |
US5039193A (en) | 1990-04-03 | 1991-08-13 | Focal Technologies Incorporated | Fibre optic single mode rotary joint |
US5262644A (en) | 1990-06-29 | 1993-11-16 | Southwest Research Institute | Remote spectroscopy for raman and brillouin scattering |
US5197470A (en) * | 1990-07-16 | 1993-03-30 | Eastman Kodak Company | Near infrared diagnostic method and instrument |
GB9015793D0 (en) | 1990-07-18 | 1990-09-05 | Medical Res Council | Confocal scanning optical microscope |
US5127730A (en) | 1990-08-10 | 1992-07-07 | Regents Of The University Of Minnesota | Multi-color laser scanning confocal imaging system |
US5845639A (en) | 1990-08-10 | 1998-12-08 | Board Of Regents Of The University Of Washington | Optical imaging methods |
JP2543516Y2 (ja) | 1990-09-25 | 1997-08-06 | 因幡電機産業株式会社 | 連結具 |
US5305759A (en) | 1990-09-26 | 1994-04-26 | Olympus Optical Co., Ltd. | Examined body interior information observing apparatus by using photo-pulses controlling gains for depths |
US5202745A (en) | 1990-11-07 | 1993-04-13 | Hewlett-Packard Company | Polarization independent optical coherence-domain reflectometry |
JP3035336B2 (ja) | 1990-11-27 | 2000-04-24 | 興和株式会社 | 血流測定装置 |
US5228001A (en) | 1991-01-23 | 1993-07-13 | Syracuse University | Optical random access memory |
US5784162A (en) | 1993-08-18 | 1998-07-21 | Applied Spectral Imaging Ltd. | Spectral bio-imaging methods for biological research, medical diagnostics and therapy |
US6198532B1 (en) | 1991-02-22 | 2001-03-06 | Applied Spectral Imaging Ltd. | Spectral bio-imaging of the eye |
US5293872A (en) * | 1991-04-03 | 1994-03-15 | Alfano Robert R | Method for distinguishing between calcified atherosclerotic tissue and fibrous atherosclerotic tissue or normal cardiovascular tissue using Raman spectroscopy |
US5465147A (en) | 1991-04-29 | 1995-11-07 | Massachusetts Institute Of Technology | Method and apparatus for acquiring images using a ccd detector array and no transverse scanner |
US5748598A (en) | 1995-12-22 | 1998-05-05 | Massachusetts Institute Of Technology | Apparatus and methods for reading multilayer storage media using short coherence length sources |
US6485413B1 (en) | 1991-04-29 | 2002-11-26 | The General Hospital Corporation | Methods and apparatus for forward-directed optical scanning instruments |
US6501551B1 (en) | 1991-04-29 | 2002-12-31 | Massachusetts Institute Of Technology | Fiber optic imaging endoscope interferometer with at least one faraday rotator |
US6564087B1 (en) | 1991-04-29 | 2003-05-13 | Massachusetts Institute Of Technology | Fiber optic needle probes for optical coherence tomography imaging |
US5956355A (en) | 1991-04-29 | 1999-09-21 | Massachusetts Institute Of Technology | Method and apparatus for performing optical measurements using a rapidly frequency-tuned laser |
US6111645A (en) | 1991-04-29 | 2000-08-29 | Massachusetts Institute Of Technology | Grating based phase control optical delay line |
US6134003A (en) | 1991-04-29 | 2000-10-17 | Massachusetts Institute Of Technology | Method and apparatus for performing optical measurements using a fiber optic imaging guidewire, catheter or endoscope |
EP0581871B2 (en) | 1991-04-29 | 2009-08-12 | Massachusetts Institute Of Technology | Apparatus for optical imaging and measurement |
US5441053A (en) | 1991-05-03 | 1995-08-15 | University Of Kentucky Research Foundation | Apparatus and method for multiple wavelength of tissue |
US5281811A (en) * | 1991-06-17 | 1994-01-25 | Litton Systems, Inc. | Digital wavelength division multiplex optical transducer having an improved decoder |
WO1993003672A1 (en) | 1991-08-20 | 1993-03-04 | Redd Douglas C B | Optical histochemical analysis, in vivo detection and real-time guidance for ablation of abnormal tissues using a raman spectroscopic detection system |
DE4128744C1 (zh) | 1991-08-29 | 1993-04-22 | Siemens Ag, 8000 Muenchen, De | |
US5177488A (en) * | 1991-10-08 | 1993-01-05 | Hughes Aircraft Company | Programmable fiber optic delay line, and radar target simulation system incorporating the same |
US5353790A (en) | 1992-01-17 | 1994-10-11 | Board Of Regents, The University Of Texas System | Method and apparatus for optical measurement of bilirubin in tissue |
US5217456A (en) * | 1992-02-24 | 1993-06-08 | Pdt Cardiovascular, Inc. | Device and method for intra-vascular optical radial imaging |
US5248876A (en) | 1992-04-21 | 1993-09-28 | International Business Machines Corporation | Tandem linear scanning confocal imaging system with focal volumes at different heights |
US5283795A (en) * | 1992-04-21 | 1994-02-01 | Hughes Aircraft Company | Diffraction grating driven linear frequency chirped laser |
US5486701A (en) * | 1992-06-16 | 1996-01-23 | Prometrix Corporation | Method and apparatus for measuring reflectance in two wavelength bands to enable determination of thin film thickness |
US5716324A (en) | 1992-08-25 | 1998-02-10 | Fuji Photo Film Co., Ltd. | Endoscope with surface and deep portion imaging systems |
EP0587514A1 (en) | 1992-09-11 | 1994-03-16 | Welch Allyn, Inc. | Processor module for video inspection probe |
US5772597A (en) | 1992-09-14 | 1998-06-30 | Sextant Medical Corporation | Surgical tool end effector |
US5698397A (en) | 1995-06-07 | 1997-12-16 | Sri International | Up-converting reporters for biological and other assays using laser excitation techniques |
EP0669820B1 (en) | 1992-11-18 | 1997-04-16 | Spectrascience, Inc. | Apparatus for diagnostic imaging |
US5383467A (en) * | 1992-11-18 | 1995-01-24 | Spectrascience, Inc. | Guidewire catheter and apparatus for diagnostic imaging |
US5785663A (en) | 1992-12-21 | 1998-07-28 | Artann Corporation | Method and device for mechanical imaging of prostate |
US5400771A (en) * | 1993-01-21 | 1995-03-28 | Pirak; Leon | Endotracheal intubation assembly and related method |
JPH06222242A (ja) * | 1993-01-27 | 1994-08-12 | Shin Etsu Chem Co Ltd | 光ファイバカプラおよびその製造方法 |
US5987346A (en) | 1993-02-26 | 1999-11-16 | Benaron; David A. | Device and method for classification of tissue |
US5414509A (en) * | 1993-03-08 | 1995-05-09 | Associated Universities, Inc. | Optical pressure/density measuring means |
DE4309056B4 (de) | 1993-03-20 | 2006-05-24 | Häusler, Gerd, Prof. Dr. | Verfahren und Vorrichtung zur Ermittlung der Entfernung und Streuintensität von streuenden Punkten |
DE4310209C2 (de) * | 1993-03-29 | 1996-05-30 | Bruker Medizintech | Optische stationäre Bildgebung in stark streuenden Medien |
DE4314189C1 (de) | 1993-04-30 | 1994-11-03 | Bodenseewerk Geraetetech | Vorrichtung zur Untersuchung von Lichtleitfasern aus Glas mittels Heterodyn-Brillouin-Spektroskopie |
US5424827A (en) * | 1993-04-30 | 1995-06-13 | Litton Systems, Inc. | Optical system and method for eliminating overlap of diffraction spectra |
SE501932C2 (sv) * | 1993-04-30 | 1995-06-26 | Ericsson Telefon Ab L M | Anordning och förfarande för dispersionskompensering i ett fiberoptiskt transmissionssystem |
US5454807A (en) | 1993-05-14 | 1995-10-03 | Boston Scientific Corporation | Medical treatment of deeply seated tissue using optical radiation |
DE69418248T2 (de) | 1993-06-03 | 1999-10-14 | Hamamatsu Photonics Kk | Optisches Laser-Abtastsystem mit Axikon |
US5840031A (en) | 1993-07-01 | 1998-11-24 | Boston Scientific Corporation | Catheters for imaging, sensing electrical potentials and ablating tissue |
US5995645A (en) | 1993-08-18 | 1999-11-30 | Applied Spectral Imaging Ltd. | Method of cancer cell detection |
US5803082A (en) | 1993-11-09 | 1998-09-08 | Staplevision Inc. | Omnispectramammography |
US5983125A (en) | 1993-12-13 | 1999-11-09 | The Research Foundation Of City College Of New York | Method and apparatus for in vivo examination of subcutaneous tissues inside an organ of a body using optical spectroscopy |
US5450203A (en) | 1993-12-22 | 1995-09-12 | Electroglas, Inc. | Method and apparatus for determining an objects position, topography and for imaging |
US5411016A (en) | 1994-02-22 | 1995-05-02 | Scimed Life Systems, Inc. | Intravascular balloon catheter for use in combination with an angioscope |
US5590660A (en) * | 1994-03-28 | 1997-01-07 | Xillix Technologies Corp. | Apparatus and method for imaging diseased tissue using integrated autofluorescence |
DE4411017C2 (de) | 1994-03-30 | 1995-06-08 | Alexander Dr Knuettel | Optische stationäre spektroskopische Bildgebung in stark streuenden Objekten durch spezielle Lichtfokussierung und Signal-Detektion von Licht unterschiedlicher Wellenlängen |
TW275570B (zh) | 1994-05-05 | 1996-05-11 | Boehringer Mannheim Gmbh | |
WO1996002184A1 (en) | 1994-07-14 | 1996-02-01 | Washington Research Foundation | Method and apparatus for detecting barrett's metaplasia of the esophagus |
US5459325A (en) | 1994-07-19 | 1995-10-17 | Molecular Dynamics, Inc. | High-speed fluorescence scanner |
US6159445A (en) | 1994-07-20 | 2000-12-12 | Nycomed Imaging As | Light imaging contrast agents |
EP1231496B1 (en) | 1994-08-18 | 2004-12-29 | Carl Zeiss AG | Optical coherence tomography assisted surgical apparatus |
US5491524A (en) | 1994-10-05 | 1996-02-13 | Carl Zeiss, Inc. | Optical coherence tomography corneal mapping apparatus |
US5740808A (en) | 1996-10-28 | 1998-04-21 | Ep Technologies, Inc | Systems and methods for guilding diagnostic or therapeutic devices in interior tissue regions |
US5817144A (en) | 1994-10-25 | 1998-10-06 | Latis, Inc. | Method for contemporaneous application OF laser energy and localized pharmacologic therapy |
US6033721A (en) | 1994-10-26 | 2000-03-07 | Revise, Inc. | Image-based three-axis positioner for laser direct write microchemical reaction |
JPH08136345A (ja) | 1994-11-10 | 1996-05-31 | Anritsu Corp | 複単色計 |
US5600486A (en) | 1995-01-30 | 1997-02-04 | Lockheed Missiles And Space Company, Inc. | Color separation microlens |
RU2100787C1 (ru) | 1995-03-01 | 1997-12-27 | Геликонов Валентин Михайлович | Оптоволоконный интерферометр и оптоволоконный пьезоэлектрический преобразователь |
WO1996028212A1 (en) | 1995-03-09 | 1996-09-19 | Innotech Usa, Inc. | Laser surgical device and method of its use |
US5868731A (en) | 1996-03-04 | 1999-02-09 | Innotech Usa, Inc. | Laser surgical device and method of its use |
US5526338A (en) | 1995-03-10 | 1996-06-11 | Yeda Research & Development Co. Ltd. | Method and apparatus for storage and retrieval with multilayer optical disks |
US5697373A (en) | 1995-03-14 | 1997-12-16 | Board Of Regents, The University Of Texas System | Optical method and apparatus for the diagnosis of cervical precancers using raman and fluorescence spectroscopies |
US5735276A (en) | 1995-03-21 | 1998-04-07 | Lemelson; Jerome | Method and apparatus for scanning and evaluating matter |
US5565983A (en) | 1995-05-26 | 1996-10-15 | The Perkin-Elmer Corporation | Optical spectrometer for detecting spectra in separate ranges |
US5621830A (en) | 1995-06-07 | 1997-04-15 | Smith & Nephew Dyonics Inc. | Rotatable fiber optic joint |
US5785651A (en) | 1995-06-07 | 1998-07-28 | Keravision, Inc. | Distance measuring confocal microscope |
WO1997001167A1 (en) | 1995-06-21 | 1997-01-09 | Massachusetts Institute Of Technology | Apparatus and method for accessing data on multilayered optical media |
ATA107495A (de) | 1995-06-23 | 1996-06-15 | Fercher Adolf Friedrich Dr | Kohärenz-biometrie und -tomographie mit dynamischem kohärentem fokus |
US6104945A (en) | 1995-08-01 | 2000-08-15 | Medispectra, Inc. | Spectral volume microprobe arrays |
CA2230228C (en) | 1995-08-24 | 2006-11-14 | Purdue Research Foundation | Fluorescence lifetime-based imaging and spectroscopy in tissues and other random media |
US6615071B1 (en) | 1995-09-20 | 2003-09-02 | Board Of Regents, The University Of Texas System | Method and apparatus for detecting vulnerable atherosclerotic plaque |
US5742419A (en) | 1995-11-07 | 1998-04-21 | The Board Of Trustees Of The Leland Stanford Junior Universtiy | Miniature scanning confocal microscope |
DE19542955C2 (de) | 1995-11-17 | 1999-02-18 | Schwind Gmbh & Co Kg Herbert | Endoskop |
US5719399A (en) | 1995-12-18 | 1998-02-17 | The Research Foundation Of City College Of New York | Imaging and characterization of tissue based upon the preservation of polarized light transmitted therethrough |
JP3699761B2 (ja) * | 1995-12-26 | 2005-09-28 | オリンパス株式会社 | 落射蛍光顕微鏡 |
US5840023A (en) | 1996-01-31 | 1998-11-24 | Oraevsky; Alexander A. | Optoacoustic imaging for medical diagnosis |
US5862273A (en) | 1996-02-23 | 1999-01-19 | Kaiser Optical Systems, Inc. | Fiber optic probe with integral optical filtering |
US5843000A (en) | 1996-05-07 | 1998-12-01 | The General Hospital Corporation | Optical biopsy forceps and method of diagnosing tissue |
ATA84696A (de) | 1996-05-14 | 1998-03-15 | Adolf Friedrich Dr Fercher | Verfahren und anordnungen zur kontrastanhebung in der optischen kohärenztomographie |
US5795295A (en) | 1996-06-25 | 1998-08-18 | Carl Zeiss, Inc. | OCT-assisted surgical microscope with multi-coordinate manipulator |
US5842995A (en) | 1996-06-28 | 1998-12-01 | Board Of Regents, The Univerisity Of Texas System | Spectroscopic probe for in vivo measurement of raman signals |
US6296608B1 (en) | 1996-07-08 | 2001-10-02 | Boston Scientific Corporation | Diagnosing and performing interventional procedures on tissue in vivo |
US5840075A (en) | 1996-08-23 | 1998-11-24 | Eclipse Surgical Technologies, Inc. | Dual laser device for transmyocardial revascularization procedures |
US6544193B2 (en) * | 1996-09-04 | 2003-04-08 | Marcio Marc Abreu | Noninvasive measurement of chemical substances |
US5801831A (en) | 1996-09-20 | 1998-09-01 | Institute For Space And Terrestrial Science | Fabry-Perot spectrometer for detecting a spatially varying spectral signature of an extended source |
US6249349B1 (en) | 1996-09-27 | 2001-06-19 | Vincent Lauer | Microscope generating a three-dimensional representation of an object |
DE19640495C2 (de) | 1996-10-01 | 1999-12-16 | Leica Microsystems | Vorrichtung zur konfokalen Oberflächenvermessung |
US5843052A (en) | 1996-10-04 | 1998-12-01 | Benja-Athon; Anuthep | Irrigation kit for application of fluids and chemicals for cleansing and sterilizing wounds |
US5752518A (en) * | 1996-10-28 | 1998-05-19 | Ep Technologies, Inc. | Systems and methods for visualizing interior regions of the body |
US5904651A (en) | 1996-10-28 | 1999-05-18 | Ep Technologies, Inc. | Systems and methods for visualizing tissue during diagnostic or therapeutic procedures |
US6044288A (en) | 1996-11-08 | 2000-03-28 | Imaging Diagnostics Systems, Inc. | Apparatus and method for determining the perimeter of the surface of an object being scanned |
US5872879A (en) | 1996-11-25 | 1999-02-16 | Boston Scientific Corporation | Rotatable connecting optical fibers |
US6437867B2 (en) | 1996-12-04 | 2002-08-20 | The Research Foundation Of The City University Of New York | Performing selected optical measurements with optical coherence domain reflectometry |
US6249630B1 (en) * | 1996-12-13 | 2001-06-19 | Imra America, Inc. | Apparatus and method for delivery of dispersion-compensated ultrashort optical pulses with high peak power |
US5871449A (en) | 1996-12-27 | 1999-02-16 | Brown; David Lloyd | Device and method for locating inflamed plaque in an artery |
US5991697A (en) | 1996-12-31 | 1999-11-23 | The Regents Of The University Of California | Method and apparatus for optical Doppler tomographic imaging of fluid flow velocity in highly scattering media |
JP2001508554A (ja) | 1996-12-31 | 2001-06-26 | コーニング インコーポレイテッド | 多層ファイバを備えた光カプラ |
US5760901A (en) | 1997-01-28 | 1998-06-02 | Zetetic Institute | Method and apparatus for confocal interference microscopy with background amplitude reduction and compensation |
JP3213250B2 (ja) | 1997-01-29 | 2001-10-02 | 株式会社生体光情報研究所 | 光計測装置 |
US5801826A (en) | 1997-02-18 | 1998-09-01 | Williams Family Trust B | Spectrometric device and method for recognizing atomic and molecular signatures |
US5836877A (en) | 1997-02-24 | 1998-11-17 | Lucid Inc | System for facilitating pathological examination of a lesion in tissue |
US6120516A (en) | 1997-02-28 | 2000-09-19 | Lumend, Inc. | Method for treating vascular occlusion |
US5968064A (en) | 1997-02-28 | 1999-10-19 | Lumend, Inc. | Catheter system for treating a vascular occlusion |
US6010449A (en) * | 1997-02-28 | 2000-01-04 | Lumend, Inc. | Intravascular catheter system for treating a vascular occlusion |
JP2001515382A (ja) | 1997-03-06 | 2001-09-18 | マサチューセッツ インスティチュート オブ テクノロジー | 生体組織の光学走査用機器 |
US6201989B1 (en) | 1997-03-13 | 2001-03-13 | Biomax Technologies Inc. | Methods and apparatus for detecting the rejection of transplanted tissue |
US6078047A (en) * | 1997-03-14 | 2000-06-20 | Lucent Technologies Inc. | Method and apparatus for terahertz tomographic imaging |
US5994690A (en) | 1997-03-17 | 1999-11-30 | Kulkarni; Manish D. | Image enhancement in optical coherence tomography using deconvolution |
JPH10267631A (ja) | 1997-03-26 | 1998-10-09 | Kowa Co | 光学測定装置 |
JPH10267830A (ja) | 1997-03-26 | 1998-10-09 | Kowa Co | 光学測定装置 |
GB9707414D0 (en) | 1997-04-11 | 1997-05-28 | Imperial College | Anatomical probe |
ATE257014T1 (de) | 1997-04-29 | 2004-01-15 | Amersham Health As | Lichtbilderzeugungskontrastmitteln |
US6117128A (en) | 1997-04-30 | 2000-09-12 | Kenton W. Gregory | Energy delivery catheter and method for the use thereof |
US5887009A (en) | 1997-05-22 | 1999-03-23 | Optical Biopsy Technologies, Inc. | Confocal optical scanning system employing a fiber laser |
US6002480A (en) | 1997-06-02 | 1999-12-14 | Izatt; Joseph A. | Depth-resolved spectroscopic optical coherence tomography |
DE69840791D1 (de) | 1997-06-02 | 2009-06-10 | Joseph A Izatt | Doppler-abbildung einer strömung mittels optischer kohaerenztomografie |
US6208415B1 (en) | 1997-06-12 | 2001-03-27 | The Regents Of The University Of California | Birefringence imaging in biological tissue using polarization sensitive optical coherent tomography |
US5920390A (en) | 1997-06-26 | 1999-07-06 | University Of North Carolina | Fiberoptic interferometer and associated method for analyzing tissue |
US6048349A (en) | 1997-07-09 | 2000-04-11 | Intraluminal Therapeutics, Inc. | Systems and methods for guiding a medical instrument through a body |
US6058352A (en) | 1997-07-25 | 2000-05-02 | Physical Optics Corporation | Accurate tissue injury assessment using hybrid neural network analysis |
US5921926A (en) | 1997-07-28 | 1999-07-13 | University Of Central Florida | Three dimensional optical imaging colposcopy |
US5892583A (en) | 1997-08-21 | 1999-04-06 | Li; Ming-Chiang | High speed inspection of a sample using superbroad radiation coherent interferometer |
US6014214A (en) | 1997-08-21 | 2000-01-11 | Li; Ming-Chiang | High speed inspection of a sample using coherence processing of scattered superbroad radiation |
US6069698A (en) | 1997-08-28 | 2000-05-30 | Olympus Optical Co., Ltd. | Optical imaging apparatus which radiates a low coherence light beam onto a test object, receives optical information from light scattered by the object, and constructs therefrom a cross-sectional image of the object |
US5920373A (en) | 1997-09-24 | 1999-07-06 | Heidelberg Engineering Optische Messysteme Gmbh | Method and apparatus for determining optical characteristics of a cornea |
US5951482A (en) | 1997-10-03 | 1999-09-14 | Intraluminal Therapeutics, Inc. | Assemblies and methods for advancing a guide wire through body tissue |
US6193676B1 (en) | 1997-10-03 | 2001-02-27 | Intraluminal Therapeutics, Inc. | Guide wire assembly |
US6091984A (en) | 1997-10-10 | 2000-07-18 | Massachusetts Institute Of Technology | Measuring tissue morphology |
US6134010A (en) | 1997-11-07 | 2000-10-17 | Lucid, Inc. | Imaging system using polarization effects to enhance image quality |
US6037579A (en) * | 1997-11-13 | 2000-03-14 | Biophotonics Information Laboratories, Ltd. | Optical interferometer employing multiple detectors to detect spatially distorted wavefront in imaging of scattering media |
US6107048A (en) | 1997-11-20 | 2000-08-22 | Medical College Of Georgia Research Institute, Inc. | Method of detecting and grading dysplasia in epithelial tissue |
GB2349730B (en) * | 1998-01-28 | 2003-04-09 | Ht Medical Systems Inc | Interface device and method for interfacing instruments to medical procedure simulation system |
US6165170A (en) | 1998-01-29 | 2000-12-26 | International Business Machines Corporation | Laser dermablator and dermablation |
US6831781B2 (en) | 1998-02-26 | 2004-12-14 | The General Hospital Corporation | Confocal microscopy with multi-spectral encoding and system and apparatus for spectroscopically encoded confocal microscopy |
US6048742A (en) | 1998-02-26 | 2000-04-11 | The United States Of America As Represented By The Secretary Of The Air Force | Process for measuring the thickness and composition of thin semiconductor films deposited on semiconductor wafers |
US6134033A (en) | 1998-02-26 | 2000-10-17 | Tyco Submarine Systems Ltd. | Method and apparatus for improving spectral efficiency in wavelength division multiplexed transmission systems |
EP2267506A3 (en) | 1998-02-26 | 2011-03-02 | The General Hospital Corporation | Confocal microscopy with multi-spectral encoding |
RU2148378C1 (ru) | 1998-03-06 | 2000-05-10 | Геликонов Валентин Михайлович | Устройство для оптической когерентной томографии, оптоволоконное сканирующее устройство и способ диагностики биоткани in vivo |
US6066102A (en) | 1998-03-09 | 2000-05-23 | Spectrascience, Inc. | Optical biopsy forceps system and method of diagnosing tissue |
US6174291B1 (en) | 1998-03-09 | 2001-01-16 | Spectrascience, Inc. | Optical biopsy system and methods for tissue diagnosis |
US6151522A (en) | 1998-03-16 | 2000-11-21 | The Research Foundation Of Cuny | Method and system for examining biological materials using low power CW excitation raman spectroscopy |
DE19814057B4 (de) | 1998-03-30 | 2009-01-02 | Carl Zeiss Meditec Ag | Anordnung zur optischen Kohärenztomographie und Kohärenztopographie |
US6175669B1 (en) | 1998-03-30 | 2001-01-16 | The Regents Of The Universtiy Of California | Optical coherence domain reflectometry guidewire |
US6384915B1 (en) | 1998-03-30 | 2002-05-07 | The Regents Of The University Of California | Catheter guided by optical coherence domain reflectometry |
US6996549B2 (en) * | 1998-05-01 | 2006-02-07 | Health Discovery Corporation | Computer-aided image analysis |
WO1999057507A1 (en) | 1998-05-01 | 1999-11-11 | Board Of Regents, The University Of Texas System | Method and apparatus for subsurface imaging |
US6053613A (en) | 1998-05-15 | 2000-04-25 | Carl Zeiss, Inc. | Optical coherence tomography with new interferometer |
FR2778838A1 (fr) | 1998-05-19 | 1999-11-26 | Koninkl Philips Electronics Nv | Procede de detection de variations d'elasticite et appareil echographique pour mettre en oeuvre ce procede |
JPH11352409A (ja) | 1998-06-05 | 1999-12-24 | Olympus Optical Co Ltd | 蛍光検出装置 |
US6549801B1 (en) | 1998-06-11 | 2003-04-15 | The Regents Of The University Of California | Phase-resolved optical coherence tomography and optical doppler tomography for imaging fluid flow in tissue with fast scanning speed and high velocity sensitivity |
US6379345B1 (en) | 1998-07-15 | 2002-04-30 | Corazon Technologies, Inc. | Methods and devices for reducing the mineral content of vascular calcified lesions |
US6166373A (en) | 1998-07-21 | 2000-12-26 | The Institute For Technology Development | Focal plane scanner with reciprocating spatial window |
JP2000046729A (ja) | 1998-07-31 | 2000-02-18 | Takahisa Mitsui | 波長分散を用いた高速光断層像計測装置および計測方法 |
US8024027B2 (en) | 1998-09-03 | 2011-09-20 | Hyperspectral Imaging, Inc. | Infrared endoscopic balloon probes |
US6741884B1 (en) * | 1998-09-03 | 2004-05-25 | Hypermed, Inc. | Infrared endoscopic balloon probes |
CA2343401C (en) | 1998-09-11 | 2009-01-27 | Spectrx, Inc. | Multi-modal optical tissue diagnostic system |
WO2000019889A1 (en) | 1998-10-08 | 2000-04-13 | University Of Kentucky Research Foundation | Methods and apparatus for in vivo identification and characterization of vulnerable atherosclerotic plaques |
JP2000121961A (ja) | 1998-10-13 | 2000-04-28 | Olympus Optical Co Ltd | 共焦点光走査プローブシステム |
US6274871B1 (en) | 1998-10-22 | 2001-08-14 | Vysis, Inc. | Method and system for performing infrared study on a biological sample |
US6324419B1 (en) | 1998-10-27 | 2001-11-27 | Nejat Guzelsu | Apparatus and method for non-invasive measurement of stretch |
JP2000126116A (ja) | 1998-10-28 | 2000-05-09 | Olympus Optical Co Ltd | 光診断システム |
AU1524700A (en) * | 1998-11-13 | 2000-06-05 | Research And Development Institute, Inc. | Programmable frequency reference for laser frequency stabilization, and arbitrary optical clock generator, using persistent spectral hole burning |
RU2149464C1 (ru) | 1999-01-19 | 2000-05-20 | Таганрогский государственный радиотехнический университет | Динамическое запоминающее устройство радиосигналов |
US6191862B1 (en) | 1999-01-20 | 2001-02-20 | Lightlab Imaging, Llc | Methods and apparatus for high speed longitudinal scanning in imaging systems |
US6272376B1 (en) | 1999-01-22 | 2001-08-07 | Cedars-Sinai Medical Center | Time-resolved, laser-induced fluorescence for the characterization of organic material |
US6445944B1 (en) | 1999-02-01 | 2002-09-03 | Scimed Life Systems | Medical scanning system and related method of scanning |
US6615072B1 (en) | 1999-02-04 | 2003-09-02 | Olympus Optical Co., Ltd. | Optical imaging device |
US6185271B1 (en) | 1999-02-16 | 2001-02-06 | Richard Estyn Kinsinger | Helical computed tomography with feedback scan control |
US20070048818A1 (en) * | 1999-03-12 | 2007-03-01 | Human Genome Sciences, Inc. | Human secreted proteins |
US6263133B1 (en) | 1999-03-29 | 2001-07-17 | Scimed Life Systems, Inc. | Optical focusing, collimating and coupling systems for use with single mode optical fiber |
US6264610B1 (en) | 1999-05-05 | 2001-07-24 | The University Of Connecticut | Combined ultrasound and near infrared diffused light imaging system |
US6353693B1 (en) | 1999-05-31 | 2002-03-05 | Sanyo Electric Co., Ltd. | Optical communication device and slip ring unit for an electronic component-mounting apparatus |
US6611833B1 (en) | 1999-06-23 | 2003-08-26 | Tissueinformatics, Inc. | Methods for profiling and classifying tissue using a database that includes indices representative of a tissue population |
US6993170B2 (en) | 1999-06-23 | 2006-01-31 | Icoria, Inc. | Method for quantitative analysis of blood vessel structure |
JP2001004447A (ja) | 1999-06-23 | 2001-01-12 | Yokogawa Electric Corp | 分光器 |
US6208887B1 (en) | 1999-06-24 | 2001-03-27 | Richard H. Clarke | Catheter-delivered low resolution Raman scattering analyzing system for detecting lesions |
US7426409B2 (en) | 1999-06-25 | 2008-09-16 | Board Of Regents, The University Of Texas System | Method and apparatus for detecting vulnerable atherosclerotic plaque |
GB9915082D0 (en) | 1999-06-28 | 1999-08-25 | Univ London | Optical fibre probe |
US6359692B1 (en) | 1999-07-09 | 2002-03-19 | Zygo Corporation | Method and system for profiling objects having multiple reflective surfaces using wavelength-tuning phase-shifting interferometry |
JP2003504627A (ja) | 1999-07-13 | 2003-02-04 | クロマビジョン メディカル システムズ インコーポレイテッド | 生物試料中の物体の自動検出 |
EP1199986B1 (en) | 1999-07-30 | 2005-06-01 | Boston Scientific Limited | Rotational and translational drive coupling for catheter assembly |
ES2279767T3 (es) | 1999-07-30 | 2007-09-01 | Ceramoptec Gmbh | Sistema de laser de diodo medico de doble longitud de onda. |
US6445939B1 (en) | 1999-08-09 | 2002-09-03 | Lightlab Imaging, Llc | Ultra-small optical probes, imaging optics, and methods for using same |
US6725073B1 (en) * | 1999-08-17 | 2004-04-20 | Board Of Regents, The University Of Texas System | Methods for noninvasive analyte sensing |
JP4464519B2 (ja) | 2000-03-21 | 2010-05-19 | オリンパス株式会社 | 光イメージング装置 |
US6687010B1 (en) | 1999-09-09 | 2004-02-03 | Olympus Corporation | Rapid depth scanning optical imaging device |
US6198956B1 (en) | 1999-09-30 | 2001-03-06 | Oti Ophthalmic Technologies Inc. | High speed sector scanning apparatus having digital electronic control |
JP2001174744A (ja) | 1999-10-06 | 2001-06-29 | Olympus Optical Co Ltd | 光走査プローブ装置 |
US6393312B1 (en) | 1999-10-13 | 2002-05-21 | C. R. Bard, Inc. | Connector for coupling an optical fiber tissue localization device to a light source |
US6308092B1 (en) | 1999-10-13 | 2001-10-23 | C. R. Bard Inc. | Optical fiber tissue localization device |
JP2001125009A (ja) | 1999-10-28 | 2001-05-11 | Asahi Optical Co Ltd | 内視鏡装置 |
IL132687A0 (en) | 1999-11-01 | 2001-03-19 | Keren Mechkarim Ichilov Pnimit | System and method for evaluating body fluid samples |
JP2003515129A (ja) | 1999-11-19 | 2003-04-22 | ジョビン イヴォン、インコーポレーテッド | コンパクトな分光蛍光計 |
DE50005933D1 (de) | 1999-11-24 | 2004-05-06 | Haag Streit Ag Koeniz | Verfahren und vorrichtung zur messung optischer eigenschaften wenigstens zweier voneinander distanzierter bereiche in einem transparenten und/oder diffusiven gegenstand |
AU1542700A (en) | 1999-12-09 | 2001-06-18 | Oti Ophthalmic Technologies Inc. | Optical mapping apparatus with adjustable depth resolution |
JP2001174404A (ja) | 1999-12-15 | 2001-06-29 | Takahisa Mitsui | 光断層像計測装置および計測方法 |
US6680780B1 (en) | 1999-12-23 | 2004-01-20 | Agere Systems, Inc. | Interferometric probe stabilization relative to subject movement |
CA2398278C (en) | 2000-01-27 | 2012-05-15 | National Research Council Of Canada | Visible-near infrared spectroscopy in burn injury assessment |
JP3660185B2 (ja) | 2000-02-07 | 2005-06-15 | 独立行政法人科学技術振興機構 | 断層像形成方法及びそのための装置 |
US6556305B1 (en) | 2000-02-17 | 2003-04-29 | Veeco Instruments, Inc. | Pulsed source scanning interferometer |
US6618143B2 (en) | 2000-02-18 | 2003-09-09 | Idexx Laboratories, Inc. | High numerical aperture flow cytometer and method of using same |
GB2372929B (en) * | 2000-03-03 | 2003-03-12 | Tera View Ltd | Apparatus and method for investigating a sample |
WO2001072215A1 (en) | 2000-03-28 | 2001-10-04 | Board Of Regents, The University Of Texas System | Enhancing contrast in biological imaging |
US6692430B2 (en) | 2000-04-10 | 2004-02-17 | C2Cure Inc. | Intra vascular imaging apparatus |
WO2001080792A2 (en) * | 2000-04-27 | 2001-11-01 | Iridex Corporation | Method and apparatus for real-time detection, control and recording of sub-clinical therapeutic laser lesions during ocular laser photocoagulation |
WO2001082786A2 (en) | 2000-05-03 | 2001-11-08 | Flock Stephen T | Optical imaging of subsurface anatomical structures and biomolecules |
US6441959B1 (en) | 2000-05-19 | 2002-08-27 | Avanex Corporation | Method and system for testing a tunable chromatic dispersion, dispersion slope, and polarization mode dispersion compensator utilizing a virtually imaged phased array |
US6301048B1 (en) | 2000-05-19 | 2001-10-09 | Avanex Corporation | Tunable chromatic dispersion and dispersion slope compensator utilizing a virtually imaged phased array |
US6560259B1 (en) * | 2000-05-31 | 2003-05-06 | Applied Optoelectronics, Inc. | Spatially coherent surface-emitting, grating coupled quantum cascade laser with unstable resonance cavity |
US6975898B2 (en) | 2000-06-19 | 2005-12-13 | University Of Washington | Medical imaging, diagnosis, and therapy using a scanning single optical fiber system |
JP4460117B2 (ja) | 2000-06-29 | 2010-05-12 | 独立行政法人理化学研究所 | グリズム |
JP2002035005A (ja) | 2000-07-21 | 2002-02-05 | Olympus Optical Co Ltd | 治療装置 |
US6441356B1 (en) * | 2000-07-28 | 2002-08-27 | Optical Biopsy Technologies | Fiber-coupled, high-speed, angled-dual-axis optical coherence scanning microscopes |
US6972894B2 (en) | 2000-08-11 | 2005-12-06 | Crystal Fibre A/S | Optical wavelength converter |
US7625335B2 (en) | 2000-08-25 | 2009-12-01 | 3Shape Aps | Method and apparatus for three-dimensional optical scanning of interior surfaces |
DE10042840A1 (de) * | 2000-08-30 | 2002-03-14 | Leica Microsystems | Vorrichtung und Verfahren zur Anregung von Fluoreszenzmikroskopmarkern bei der Mehrphotonen-Rastermikroskopie |
WO2002021170A1 (en) | 2000-09-05 | 2002-03-14 | Arroyo Optics, Inc. | System and method for fabricating components of precise optical path length |
JP2002095663A (ja) | 2000-09-26 | 2002-04-02 | Fuji Photo Film Co Ltd | センチネルリンパ節光断層画像取得方法および装置 |
JP2002113017A (ja) | 2000-10-05 | 2002-04-16 | Fuji Photo Film Co Ltd | レーザ治療装置 |
EP1434522B1 (en) | 2000-10-30 | 2010-01-13 | The General Hospital Corporation | Optical systems for tissue analysis |
JP3842101B2 (ja) | 2000-10-31 | 2006-11-08 | 富士写真フイルム株式会社 | 内視鏡装置 |
AU1210502A (en) | 2000-10-31 | 2002-05-15 | Forskningsct Riso | Optical amplification in coherent optical frequency modulated continuous wave reflectometry |
US6687036B2 (en) | 2000-11-03 | 2004-02-03 | Nuonics, Inc. | Multiplexed optical scanner technology |
JP2002148185A (ja) | 2000-11-08 | 2002-05-22 | Fuji Photo Film Co Ltd | Oct装置 |
US9295391B1 (en) | 2000-11-10 | 2016-03-29 | The General Hospital Corporation | Spectrally encoded miniature endoscopic imaging probe |
US6665075B2 (en) | 2000-11-14 | 2003-12-16 | Wm. Marshurice University | Interferometric imaging system and method |
DE10057539B4 (de) | 2000-11-20 | 2008-06-12 | Robert Bosch Gmbh | Interferometrische Messvorrichtung |
US6558324B1 (en) | 2000-11-22 | 2003-05-06 | Siemens Medical Solutions, Inc., Usa | System and method for strain image display |
US6856712B2 (en) | 2000-11-27 | 2005-02-15 | University Of Washington | Micro-fabricated optical waveguide for use in scanning fiber displays and scanned fiber image acquisition |
US7027633B2 (en) * | 2000-11-30 | 2006-04-11 | Foran David J | Collaborative diagnostic systems |
US6501878B2 (en) | 2000-12-14 | 2002-12-31 | Nortel Networks Limited | Optical fiber termination |
US6687007B1 (en) | 2000-12-14 | 2004-02-03 | Kestrel Corporation | Common path interferometer for spectral image generation |
US6515752B2 (en) | 2000-12-28 | 2003-02-04 | Coretek, Inc. | Wavelength monitoring system |
US7230708B2 (en) * | 2000-12-28 | 2007-06-12 | Dmitri Olegovich Lapotko | Method and device for photothermal examination of microinhomogeneities |
WO2002053050A1 (en) | 2000-12-28 | 2002-07-11 | Palomar Medical Technologies, Inc. | Method and apparatus for therapeutic emr treatment of the skin |
EP1221581A1 (en) | 2001-01-04 | 2002-07-10 | Universität Stuttgart | Interferometer |
JP2002205434A (ja) | 2001-01-10 | 2002-07-23 | Seiko Epson Corp | 画像出力装置及びプリンティングシステム |
US7177491B2 (en) | 2001-01-12 | 2007-02-13 | Board Of Regents The University Of Texas System | Fiber-based optical low coherence tomography |
JP3628615B2 (ja) | 2001-01-16 | 2005-03-16 | 独立行政法人科学技術振興機構 | ヘテロダインビート画像同期測定装置 |
US6697652B2 (en) * | 2001-01-19 | 2004-02-24 | Massachusetts Institute Of Technology | Fluorescence, reflectance and light scattering spectroscopy for measuring tissue |
WO2002075242A2 (en) | 2001-01-22 | 2002-09-26 | Roth Jonathan E | Method and apparatus for polarization-sensitive optical coherence tomography |
US7973936B2 (en) | 2001-01-30 | 2011-07-05 | Board Of Trustees Of Michigan State University | Control system and apparatus for use with ultra-fast laser |
GB0104378D0 (en) | 2001-02-22 | 2001-04-11 | Expro North Sea Ltd | Improved tubing coupling |
US6654127B2 (en) | 2001-03-01 | 2003-11-25 | Carl Zeiss Ophthalmic Systems, Inc. | Optical delay line |
US7244232B2 (en) | 2001-03-07 | 2007-07-17 | Biomed Solutions, Llc | Process for identifying cancerous and/or metastatic cells of a living organism |
IL142773A (en) | 2001-03-08 | 2007-10-31 | Xtellus Inc | Fiber optic damper |
JP2002263055A (ja) | 2001-03-12 | 2002-09-17 | Olympus Optical Co Ltd | 内視鏡先端フード |
US6563995B2 (en) | 2001-04-02 | 2003-05-13 | Lightwave Electronics | Optical wavelength filtering apparatus with depressed-index claddings |
US6552796B2 (en) | 2001-04-06 | 2003-04-22 | Lightlab Imaging, Llc | Apparatus and method for selective data collection and signal to noise ratio enhancement using optical coherence tomography |
US7139598B2 (en) | 2002-04-04 | 2006-11-21 | Veralight, Inc. | Determination of a measure of a glycation end-product or disease state using tissue fluorescence |
US8046057B2 (en) | 2001-04-11 | 2011-10-25 | Clarke Dana S | Tissue structure identification in advance of instrument |
DE10118760A1 (de) | 2001-04-17 | 2002-10-31 | Med Laserzentrum Luebeck Gmbh | Verfahren zur Ermittlung der Laufzeitverteilung und Anordnung |
US9897538B2 (en) | 2001-04-30 | 2018-02-20 | The General Hospital Corporation | Method and apparatus for improving image clarity and sensitivity in optical coherence tomography using dynamic feedback to control focal properties and coherence gating |
US20030103995A1 (en) | 2001-06-04 | 2003-06-05 | Hamblin Michael R. | Detection and therapy of vulnerable plaque with photodynamic compounds |
EP1191321B1 (en) | 2001-06-07 | 2002-12-11 | Agilent Technologies, Inc. (a Delaware corporation) | Determination of properties of an optical device |
US6879851B2 (en) | 2001-06-07 | 2005-04-12 | Lightlab Imaging, Llc | Fiber optic endoscopic gastrointestinal probe |
DE10129651B4 (de) * | 2001-06-15 | 2010-07-08 | Carl Zeiss Jena Gmbh | Verfahren zur Kompensation der Dispersion in Signalen von Kurzkohärenz- und/oder OCT-Interferometern |
US6702744B2 (en) | 2001-06-20 | 2004-03-09 | Advanced Cardiovascular Systems, Inc. | Agents that stimulate therapeutic angiogenesis and techniques and devices that enable their delivery |
US20040166593A1 (en) | 2001-06-22 | 2004-08-26 | Nolte David D. | Adaptive interferometric multi-analyte high-speed biosensor |
US6685885B2 (en) | 2001-06-22 | 2004-02-03 | Purdue Research Foundation | Bio-optical compact dist system |
AU2002316500A1 (en) | 2001-07-02 | 2003-01-21 | Palomar Medical Technologies, Inc. | Laser device for medical/cosmetic procedures |
US6795199B2 (en) * | 2001-07-18 | 2004-09-21 | Avraham Suhami | Method and apparatus for dispersion compensated reflected time-of-flight tomography |
WO2003012405A2 (en) | 2001-08-03 | 2003-02-13 | Rollins Andrew M | Aspects of basic oct engine technologies for high speed optical coherence tomography and light source and other improvements in oct |
US6900899B2 (en) * | 2001-08-20 | 2005-05-31 | Agilent Technologies, Inc. | Interferometers with coated polarizing beam splitters that are rotated to optimize extinction ratios |
US20030045798A1 (en) | 2001-09-04 | 2003-03-06 | Richard Hular | Multisensor probe for tissue identification |
EP1293925A1 (en) * | 2001-09-18 | 2003-03-19 | Agfa-Gevaert | Radiographic scoring method |
US6961123B1 (en) | 2001-09-28 | 2005-11-01 | The Texas A&M University System | Method and apparatus for obtaining information from polarization-sensitive optical coherence tomography |
JP2003102672A (ja) | 2001-10-01 | 2003-04-08 | Japan Science & Technology Corp | 病変等の対象部位を自動的に検知かつ治療または採取する方法およびその装置 |
DE10150934A1 (de) * | 2001-10-09 | 2003-04-10 | Zeiss Carl Jena Gmbh | Verfahren und Anordnung zur tiefenaufgelösten Erfassung von Proben |
US7822470B2 (en) | 2001-10-11 | 2010-10-26 | Osypka Medical Gmbh | Method for determining the left-ventricular ejection time TLVE of a heart of a subject |
US6980299B1 (en) | 2001-10-16 | 2005-12-27 | General Hospital Corporation | Systems and methods for imaging a sample |
US6658278B2 (en) | 2001-10-17 | 2003-12-02 | Terumo Cardiovascular Systems Corporation | Steerable infrared imaging catheter having steering fins |
US7006231B2 (en) | 2001-10-18 | 2006-02-28 | Scimed Life Systems, Inc. | Diffraction grating based interferometric systems and methods |
US6749344B2 (en) | 2001-10-24 | 2004-06-15 | Scimed Life Systems, Inc. | Connection apparatus for optical coherence tomography catheters |
US7588535B2 (en) | 2001-12-11 | 2009-09-15 | C2Cure Inc. | Apparatus, method and system for intravascular photographic imaging |
US20030216719A1 (en) | 2001-12-12 | 2003-11-20 | Len Debenedictis | Method and apparatus for treating skin using patterns of optical energy |
EP1459111B1 (en) | 2001-12-14 | 2007-06-06 | Agilent Technologies, Inc. | External cavity with retro-reflecting device in particular for tunable lasers |
US7736301B1 (en) | 2001-12-18 | 2010-06-15 | Advanced Cardiovascular Systems, Inc. | Rotatable ferrules and interfaces for use with an optical guidewire |
US7365858B2 (en) * | 2001-12-18 | 2008-04-29 | Massachusetts Institute Of Technology | Systems and methods for phase measurements |
US6947787B2 (en) | 2001-12-21 | 2005-09-20 | Advanced Cardiovascular Systems, Inc. | System and methods for imaging within a body lumen |
US20080154090A1 (en) | 2005-01-04 | 2008-06-26 | Dune Medical Devices Ltd. | Endoscopic System for In-Vivo Procedures |
JP3962338B2 (ja) * | 2002-01-10 | 2007-08-22 | 日本電信電話株式会社 | 光パルスパターン発生器 |
US7355716B2 (en) * | 2002-01-24 | 2008-04-08 | The General Hospital Corporation | Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands |
CA2474331A1 (en) | 2002-01-24 | 2003-07-31 | The General Hospital Corporation | Apparatus and method for rangings and noise reduction of low coherence interferometry lci and optical coherence tomography (oct) signals by parallel detection of spectral bands |
JP4472991B2 (ja) | 2002-02-14 | 2010-06-02 | イマラックス・コーポレーション | 対象の研究方法およびその光学干渉計(変型) |
US20030165263A1 (en) | 2002-02-19 | 2003-09-04 | Hamer Michael J. | Histological assessment |
US7116887B2 (en) | 2002-03-19 | 2006-10-03 | Nufern | Optical fiber |
US7006232B2 (en) * | 2002-04-05 | 2006-02-28 | Case Western Reserve University | Phase-referenced doppler optical coherence tomography |
US7113818B2 (en) | 2002-04-08 | 2006-09-26 | Oti Ophthalmic Technologies Inc. | Apparatus for high resolution imaging of moving organs |
US20030236443A1 (en) | 2002-04-19 | 2003-12-25 | Cespedes Eduardo Ignacio | Methods and apparatus for the identification and stabilization of vulnerable plaque |
JP4135551B2 (ja) | 2002-05-07 | 2008-08-20 | 松下電工株式会社 | ポジションセンサ |
JP3834789B2 (ja) * | 2002-05-17 | 2006-10-18 | 独立行政法人科学技術振興機構 | 自律型超短光パルス圧縮・位相補償・波形整形装置 |
US7272252B2 (en) | 2002-06-12 | 2007-09-18 | Clarient, Inc. | Automated system for combining bright field and fluorescent microscopy |
RU2213421C1 (ru) | 2002-06-21 | 2003-09-27 | Южно-Российский государственный университет экономики и сервиса | Динамическое запоминающее устройство радиосигналов |
US20040039252A1 (en) * | 2002-06-27 | 2004-02-26 | Koch Kenneth Elmon | Self-navigating endotracheal tube |
JP3621693B2 (ja) | 2002-07-01 | 2005-02-16 | フジノン株式会社 | 干渉計装置 |
AU2003261158A1 (en) | 2002-07-12 | 2004-02-02 | Joe Izatt | Method and device for quantitative image correction for optical coherence tomography |
JP3950378B2 (ja) | 2002-07-19 | 2007-08-01 | 新日本製鐵株式会社 | 同期機 |
JP4258015B2 (ja) | 2002-07-31 | 2009-04-30 | 毅 椎名 | 超音波診断システム、歪み分布表示方法及び弾性係数分布表示方法 |
US7283247B2 (en) | 2002-09-25 | 2007-10-16 | Olympus Corporation | Optical probe system |
AU2003272667A1 (en) | 2002-09-26 | 2004-04-19 | Bio Techplex Corporation | Method and apparatus for screening using a waveform modulated led |
CN100401994C (zh) | 2002-10-18 | 2008-07-16 | 阿里耶·谢尔 | 配有成像导丝的动脉粥样硬化斑移除*** |
US20040092829A1 (en) | 2002-11-07 | 2004-05-13 | Simon Furnish | Spectroscope with modified field-of-view |
US6847449B2 (en) | 2002-11-27 | 2005-01-25 | The United States Of America As Represented By The Secretary Of The Navy | Method and apparatus for reducing speckle in optical coherence tomography images |
EP1426799A3 (en) | 2002-11-29 | 2005-05-18 | Matsushita Electric Industrial Co., Ltd. | Optical demultiplexer, optical multi-/demultiplexer, and optical device |
GB0229734D0 (en) * | 2002-12-23 | 2003-01-29 | Qinetiq Ltd | Grading oestrogen and progesterone receptors expression |
JP4148771B2 (ja) | 2002-12-27 | 2008-09-10 | 株式会社トプコン | 医療機械のレーザ装置 |
US7643153B2 (en) * | 2003-01-24 | 2010-01-05 | The General Hospital Corporation | Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands |
EP2319404B1 (en) | 2003-01-24 | 2015-03-11 | The General Hospital Corporation | System and method for identifying tissue low-coherence interferometry |
US7075658B2 (en) * | 2003-01-24 | 2006-07-11 | Duke University | Method for optical coherence tomography imaging with molecular contrast |
JP4338412B2 (ja) | 2003-02-24 | 2009-10-07 | Hoya株式会社 | 共焦点プローブおよび共焦点顕微鏡 |
US7271918B2 (en) | 2003-03-06 | 2007-09-18 | Zygo Corporation | Profiling complex surface structures using scanning interferometry |
JP4805142B2 (ja) | 2003-03-31 | 2011-11-02 | ザ ジェネラル ホスピタル コーポレイション | 光路長が変更された異なる角度の光の合成により光学的に干渉する断層撮影におけるスペックルの減少 |
JP2004317437A (ja) | 2003-04-18 | 2004-11-11 | Olympus Corp | 光イメージング装置 |
JP4135550B2 (ja) | 2003-04-18 | 2008-08-20 | 日立電線株式会社 | 半導体発光デバイス |
CN101785656B (zh) | 2003-05-12 | 2012-08-15 | 富士胶片株式会社 | 气囊式内窥镜的气囊控制装置 |
SE527164C2 (sv) | 2003-05-14 | 2006-01-10 | Spectracure Ab | Anordning och metod för terapi och diagnostik innefattande optiska komponenter för distribution av strålning |
US7376455B2 (en) | 2003-05-22 | 2008-05-20 | Scimed Life Systems, Inc. | Systems and methods for dynamic optical imaging |
US7697145B2 (en) | 2003-05-28 | 2010-04-13 | Duke University | System for fourier domain optical coherence tomography |
JP2007501447A (ja) * | 2003-05-29 | 2007-01-25 | ミシガン大学リージェンツ | ダブルクラッドファイバー走査型顕微鏡 |
US7263394B2 (en) | 2003-06-04 | 2007-08-28 | Tomophase Corporation | Coherence-gated optical glucose monitor |
US6943881B2 (en) | 2003-06-04 | 2005-09-13 | Tomophase Corporation | Measurements of optical inhomogeneity and other properties in substances using propagation modes of light |
EP2290337B1 (en) * | 2003-06-06 | 2018-12-12 | The General Hospital Corporation | Wavelength tuning laser |
US7458683B2 (en) | 2003-06-16 | 2008-12-02 | Amo Manufacturing Usa, Llc | Methods and devices for registering optical measurement datasets of an optical system |
US7170913B2 (en) * | 2003-06-19 | 2007-01-30 | Multiwave Photonics, Sa | Laser source with configurable output beam characteristics |
US20040260182A1 (en) | 2003-06-23 | 2004-12-23 | Zuluaga Andres F. | Intraluminal spectroscope with wall contacting probe |
JP4677208B2 (ja) | 2003-07-29 | 2011-04-27 | オリンパス株式会社 | 共焦点顕微鏡 |
US7307734B2 (en) | 2003-08-14 | 2007-12-11 | University Of Central Florida | Interferometric sensor for characterizing materials |
US7539530B2 (en) * | 2003-08-22 | 2009-05-26 | Infraredx, Inc. | Method and system for spectral examination of vascular walls through blood during cardiac motion |
US20050083534A1 (en) | 2003-08-28 | 2005-04-21 | Riza Nabeel A. | Agile high sensitivity optical sensor |
JP3956921B2 (ja) | 2003-09-01 | 2007-08-08 | コニカミノルタビジネステクノロジーズ株式会社 | 画像形成装置 |
JP2005077964A (ja) * | 2003-09-03 | 2005-03-24 | Fujitsu Ltd | 分光装置 |
US20050059894A1 (en) * | 2003-09-16 | 2005-03-17 | Haishan Zeng | Automated endoscopy device, diagnostic method, and uses |
US7935055B2 (en) * | 2003-09-19 | 2011-05-03 | Siemens Medical Solutions Usa, Inc. | System and method of measuring disease severity of a patient before, during and after treatment |
US8172747B2 (en) | 2003-09-25 | 2012-05-08 | Hansen Medical, Inc. | Balloon visualization for traversing a tissue wall |
US7292792B2 (en) | 2003-09-30 | 2007-11-06 | Lucent Technologies Inc. | High speed modulation of optical subcarriers |
CN103181753B (zh) | 2003-10-27 | 2016-12-28 | 通用医疗公司 | 用于使用频域干涉测量法进行光学成像的方法和设备 |
DE10351319B4 (de) | 2003-10-31 | 2005-10-20 | Med Laserzentrum Luebeck Gmbh | Interferometer für die optische Kohärenztomographie |
US7551293B2 (en) | 2003-11-28 | 2009-06-23 | The General Hospital Corporation | Method and apparatus for three-dimensional spectrally encoded imaging |
DE10358735B4 (de) | 2003-12-15 | 2011-04-21 | Siemens Ag | Kathetereinrichtung umfassend einen Katheter, insbesondere einen intravaskulären Katheter |
JP4414771B2 (ja) | 2004-01-08 | 2010-02-10 | オリンパス株式会社 | 共焦点顕微分光装置 |
RU2255426C1 (ru) | 2004-02-19 | 2005-06-27 | Южно-Российский государственный университет экономики и сервиса | Динамическое запоминающее устройство радиосигналов с последовательной бинарной волоконно-оптической структурой |
JP4462959B2 (ja) | 2004-02-25 | 2010-05-12 | 富士通株式会社 | 顕微鏡画像撮影システム及び方法 |
WO2005082225A1 (en) | 2004-02-27 | 2005-09-09 | Optiscan Pty Ltd | Optical element |
US7190464B2 (en) | 2004-05-14 | 2007-03-13 | Medeikon Corporation | Low coherence interferometry for detecting and characterizing plaques |
AU2004320269B2 (en) | 2004-05-29 | 2011-07-21 | The General Hospital Corporation | Process, system and software arrangement for a chromatic dispersion compensation using reflective layers in optical coherence tomography (OCT) imaging |
WO2006014392A1 (en) | 2004-07-02 | 2006-02-09 | The General Hospital Corporation | Endoscopic imaging probe comprising dual clad fibre |
US8081316B2 (en) * | 2004-08-06 | 2011-12-20 | The General Hospital Corporation | Process, system and software arrangement for determining at least one location in a sample using an optical coherence tomography |
US20090227994A1 (en) | 2004-08-10 | 2009-09-10 | The Regents Of The University Of California | Device and method for the delivery and/or elimination of compounds in tissue |
US7113625B2 (en) | 2004-10-01 | 2006-09-26 | U.S. Pathology Labs, Inc. | System and method for image analysis of slides |
KR100584697B1 (ko) * | 2004-10-08 | 2006-05-30 | 한국전자통신연구원 | 변조 주파수 가변형 광 발진기 |
SE0402435L (sv) | 2004-10-08 | 2006-04-09 | Trajan Badju | Förfarande och system för alstring av tredimensionella bilder |
DE102004051147A1 (de) * | 2004-10-15 | 2006-04-20 | Callidus Precision Systems Gmbh | Verfahren und Einrichtung für einen passiven optischen Impulsvervielfacher zur Erzeugung einer Impulsfolge für ein scannendes Laserentfernungsmessgerät |
EP1819270B1 (en) * | 2004-10-29 | 2012-12-19 | The General Hospital Corporation | Polarization-sensitive optical coherence tomography |
JP5623692B2 (ja) * | 2004-11-02 | 2014-11-12 | ザ ジェネラル ホスピタル コーポレイション | 試料の画像形成のための光ファイバ回転装置、光学システム及び方法 |
US7417740B2 (en) | 2004-11-12 | 2008-08-26 | Medeikon Corporation | Single trace multi-channel low coherence interferometric sensor |
US8617152B2 (en) * | 2004-11-15 | 2013-12-31 | Medtronic Ablation Frontiers Llc | Ablation system with feedback |
WO2006058187A2 (en) | 2004-11-23 | 2006-06-01 | Robert Eric Betzig | Optical lattice microscopy |
US8315282B2 (en) | 2005-01-20 | 2012-11-20 | Massachusetts Institute Of Technology | Fourier domain mode locking: method and apparatus for control and improved performance |
US7342659B2 (en) * | 2005-01-21 | 2008-03-11 | Carl Zeiss Meditec, Inc. | Cross-dispersed spectrometer in a spectral domain optical coherence tomography system |
US7330270B2 (en) * | 2005-01-21 | 2008-02-12 | Carl Zeiss Meditec, Inc. | Method to suppress artifacts in frequency-domain optical coherence tomography |
HU227859B1 (en) | 2005-01-27 | 2012-05-02 | E Szilveszter Vizi | Real-time 3d nonlinear microscope measuring system and its application |
US7664300B2 (en) * | 2005-02-03 | 2010-02-16 | Sti Medical Systems, Llc | Uterine cervical cancer computer-aided-diagnosis (CAD) |
DE102005007574B3 (de) | 2005-02-18 | 2006-08-31 | Siemens Ag | Kathetereinrichtung |
US7649160B2 (en) * | 2005-02-23 | 2010-01-19 | Lyncee Tec S.A. | Wave front sensing method and apparatus |
JP4628820B2 (ja) | 2005-02-25 | 2011-02-09 | サンテック株式会社 | 波長走査型ファイバレーザ光源 |
US7530948B2 (en) * | 2005-02-28 | 2009-05-12 | University Of Washington | Tethered capsule endoscope for Barrett's Esophagus screening |
DE102005010790A1 (de) | 2005-03-09 | 2006-09-14 | Basf Ag | Photovoltaische Zelle mit einem darin enthaltenen photovoltaisch aktiven Halbleitermaterial |
US20060224053A1 (en) | 2005-03-30 | 2006-10-05 | Skyline Biomedical, Inc. | Apparatus and method for non-invasive and minimally-invasive sensing of venous oxygen saturation and pH levels |
EP1872109A1 (en) * | 2005-04-22 | 2008-01-02 | The General Hospital Corporation | Arrangements, systems and methods capable of providing spectral-domain polarization-sensitive optical coherence tomography |
WO2006116362A2 (en) * | 2005-04-25 | 2006-11-02 | The Trustees Of Boston University | Structured substrates for optical surface profiling |
EP2453238B1 (en) * | 2005-05-23 | 2016-12-21 | Harald F. Hess | Optical microscopy with phototransformable optical labels |
US7859679B2 (en) | 2005-05-31 | 2010-12-28 | The General Hospital Corporation | System, method and arrangement which can use spectral encoding heterodyne interferometry techniques for imaging |
EP1889037A2 (en) | 2005-06-01 | 2008-02-20 | The General Hospital Corporation | Apparatus, method and system for performing phase-resolved optical frequency domain imaging |
WO2007005913A2 (en) | 2005-07-01 | 2007-01-11 | Infotonics Technology Center, Inc. | Non-invasive monitoring system |
DE102005034443A1 (de) | 2005-07-22 | 2007-02-22 | Carl Zeiss Jena Gmbh | Auflösungsgesteigerte Lumineszenz-Mikroskopie |
JP4376837B2 (ja) * | 2005-08-05 | 2009-12-02 | サンテック株式会社 | 波長走査型レーザ光源 |
WO2007030835A2 (en) | 2005-09-10 | 2007-03-15 | Baer Stephen C | High resolution microscopy using an optically switchable fluorophore |
US8114581B2 (en) | 2005-09-15 | 2012-02-14 | The Regents Of The University Of California | Methods and compositions for detecting neoplastic cells |
US20070121196A1 (en) | 2005-09-29 | 2007-05-31 | The General Hospital Corporation | Method and apparatus for method for viewing and analyzing of one or more biological samples with progressively increasing resolutions |
US7450241B2 (en) * | 2005-09-30 | 2008-11-11 | Infraredx, Inc. | Detecting vulnerable plaque |
US7400410B2 (en) * | 2005-10-05 | 2008-07-15 | Carl Zeiss Meditec, Inc. | Optical coherence tomography for eye-length measurement |
US7545504B2 (en) * | 2005-10-07 | 2009-06-09 | Biotigen, Inc. | Imaging systems using unpolarized light and related methods and controllers |
US7408649B2 (en) * | 2005-10-26 | 2008-08-05 | Kla-Tencor Technologies Corporation | Method and apparatus for optically analyzing a surface |
US8145018B2 (en) | 2006-01-19 | 2012-03-27 | The General Hospital Corporation | Apparatus for obtaining information for a structure using spectrally-encoded endoscopy techniques and methods for producing one or more optical arrangements |
JP5384944B2 (ja) * | 2006-01-19 | 2014-01-08 | ザ ジェネラル ホスピタル コーポレイション | ビームスキャニングによる上皮性管腔器官の光学的撮像システム |
WO2007090147A2 (en) | 2006-01-31 | 2007-08-09 | The Board Of Trustees Of The University Of Illinois | Method and apparatus for measurement of optical properties in tissue |
JP5519152B2 (ja) | 2006-02-08 | 2014-06-11 | ザ ジェネラル ホスピタル コーポレイション | 光学顕微鏡法を用いて解剖学的サンプルに関わる情報を取得するための装置 |
US8184367B2 (en) | 2006-02-15 | 2012-05-22 | University Of Central Florida Research Foundation | Dynamically focused optical instrument |
JP5135324B2 (ja) | 2006-04-05 | 2013-02-06 | ザ ジェネラル ホスピタル コーポレイション | サンプルの偏光感応性光周波数領域画像形成のための方法、構成およびシステム |
US20070253901A1 (en) | 2006-04-27 | 2007-11-01 | David Deng | Atherosclerosis genes and related reagents and methods of use thereof |
WO2007127395A2 (en) | 2006-04-28 | 2007-11-08 | Bioptigen, Inc. | Methods, systems and computer program products for optical coherence tomography (oct) using automatic dispersion compensation |
US7782464B2 (en) | 2006-05-12 | 2010-08-24 | The General Hospital Corporation | Processes, arrangements and systems for providing a fiber layer thickness map based on optical coherence tomography images |
US8838213B2 (en) * | 2006-10-19 | 2014-09-16 | The General Hospital Corporation | Apparatus and method for obtaining and providing imaging information associated with at least one portion of a sample, and effecting such portion(s) |
JP4435137B2 (ja) * | 2006-10-23 | 2010-03-17 | アンリツ株式会社 | 高速波長掃引光源 |
US8554035B2 (en) * | 2006-10-26 | 2013-10-08 | Cornell Research Foundation, Inc. | Production of optical pulses at a desired wavelength using soliton self-frequency shift in higher-order-mode fiber |
EP2079363B1 (en) | 2006-10-30 | 2020-06-10 | Elfi-Tech Ltd | Method for in vivo measurement of biological parameters |
DE102006054556A1 (de) | 2006-11-20 | 2008-05-21 | Zimmer Medizinsysteme Gmbh | Vorrichtung und Verfahren zum nicht-invasiven, optischen Erfassen von chemischen und physikalischen Blutwerten und Körperinhaltsstoffen |
US20080204762A1 (en) | 2007-01-17 | 2008-08-28 | Duke University | Methods, systems, and computer program products for removing undesired artifacts in fourier domain optical coherence tomography (FDOCT) systems using integrating buckets |
JP5507258B2 (ja) * | 2007-01-19 | 2014-05-28 | ザ ジェネラル ホスピタル コーポレイション | 光周波数領域イメージングにおける測定深度を制御するための装置及び方法 |
WO2008118781A2 (en) * | 2007-03-23 | 2008-10-02 | The General Hospital Corporation | Methods, arrangements and apparatus for utilizing a wavelength-swept laser using angular scanning and dispersion procedures |
JP5227525B2 (ja) | 2007-03-23 | 2013-07-03 | 株式会社日立製作所 | 生体光計測装置 |
US8244334B2 (en) * | 2007-04-10 | 2012-08-14 | University Of Southern California | Methods and systems for blood flow measurement using doppler optical coherence tomography |
US8115919B2 (en) | 2007-05-04 | 2012-02-14 | The General Hospital Corporation | Methods, arrangements and systems for obtaining information associated with a sample using optical microscopy |
JP2009016396A (ja) * | 2007-06-29 | 2009-01-22 | Optical Comb Inc | 波長走査型ファイバレーザ光源 |
US8166967B2 (en) * | 2007-08-15 | 2012-05-01 | Chunyuan Qiu | Systems and methods for intubation |
US20090219544A1 (en) | 2007-09-05 | 2009-09-03 | The General Hospital Corporation | Systems, methods and computer-accessible medium for providing spectral-domain optical coherence phase microscopy for cell and deep tissue imaging |
US20090131801A1 (en) * | 2007-10-12 | 2009-05-21 | The General Hospital Corporation | Systems and processes for optical imaging of luminal anatomic structures |
US9332942B2 (en) | 2008-01-28 | 2016-05-10 | The General Hospital Corporation | Systems, processes and computer-accessible medium for providing hybrid flourescence and optical coherence tomography imaging |
JP5192247B2 (ja) | 2008-01-29 | 2013-05-08 | 並木精密宝石株式会社 | Octプローブ |
US7898656B2 (en) | 2008-04-30 | 2011-03-01 | The General Hospital Corporation | Apparatus and method for cross axis parallel spectroscopy |
US8184298B2 (en) | 2008-05-21 | 2012-05-22 | The Board Of Trustees Of The University Of Illinois | Spatial light interference microscopy and fourier transform light scattering for cell and tissue characterization |
US8133127B1 (en) | 2008-07-21 | 2012-03-13 | Synder Terrance W | Sports training device and methods of use |
US20110160681A1 (en) | 2008-12-04 | 2011-06-30 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Systems, devices, and methods including catheters having light removable coatings based on a sensed condition |
US8457715B2 (en) | 2009-04-08 | 2013-06-04 | Covidien Lp | System and method for determining placement of a tracheal tube |
US9089331B2 (en) * | 2009-07-31 | 2015-07-28 | Case Western Reserve University | Characterizing ablation lesions using optical coherence tomography (OCT) |
US20120228523A1 (en) | 2009-11-09 | 2012-09-13 | Tata Institute Of Fundamental Research | Biological laser plasma x-ray point source |
DK2542145T3 (da) | 2010-03-05 | 2020-11-02 | Massachusetts Gen Hospital | Systemer der tilvejebringer mikroskopiske billeder af mindst en anatomisk struktur ved en bestemt opløsning |
-
2010
- 2010-02-04 EP EP10739129.4A patent/EP2394336B1/en active Active
- 2010-02-04 JP JP2011548430A patent/JP6053284B2/ja active Active
- 2010-02-04 CA CA2749670A patent/CA2749670A1/en not_active Abandoned
- 2010-02-04 US US12/700,552 patent/US9178330B2/en active Active
- 2010-02-04 CN CN201080006535.XA patent/CN102308444B/zh active Active
- 2010-02-04 CN CN201410198697.8A patent/CN104134928A/zh active Pending
- 2010-02-04 WO PCT/US2010/023215 patent/WO2010091190A2/en active Application Filing
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2015
- 2015-04-07 JP JP2015078544A patent/JP2015163887A/ja active Pending
-
2017
- 2017-06-07 JP JP2017112390A patent/JP6548695B2/ja active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1077046A (zh) * | 1991-12-30 | 1993-10-06 | 菲利浦电子有限公司 | 光学装置和包含该装置的对信息面扫描的设备 |
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US9178330B2 (en) | 2015-11-03 |
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