CN102292114A - Drug delivery and substance transfer facilitated by nano-enhanced device having aligned carbon nanotubes protruding from device surface - Google Patents

Drug delivery and substance transfer facilitated by nano-enhanced device having aligned carbon nanotubes protruding from device surface Download PDF

Info

Publication number
CN102292114A
CN102292114A CN2010800053668A CN201080005366A CN102292114A CN 102292114 A CN102292114 A CN 102292114A CN 2010800053668 A CN2010800053668 A CN 2010800053668A CN 201080005366 A CN201080005366 A CN 201080005366A CN 102292114 A CN102292114 A CN 102292114A
Authority
CN
China
Prior art keywords
cnt
medicine
carbon nano
tissue
cluster
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2010800053668A
Other languages
Chinese (zh)
Inventor
莫泰扎·格哈比
以利亚·B·桑塞姆
阿德里安努斯·I·艾莉亚
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
California Institute of Technology CalTech
Original Assignee
California Institute of Technology CalTech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by California Institute of Technology CalTech filed Critical California Institute of Technology CalTech
Publication of CN102292114A publication Critical patent/CN102292114A/en
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/443—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with carbon fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6957—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a device or a kit, e.g. stents or microdevices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters
    • A61M25/104—Balloon catheters used for angioplasty
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/44—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for cooling or heating the devices or media
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A61N1/303—Constructional details
    • A61N1/306—Arrangements where at least part of the apparatus is introduced into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/062—Photodynamic therapy, i.e. excitation of an agent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C70/00—Shaping composites, i.e. plastics material comprising reinforcements, fillers or preformed parts, e.g. inserts
    • B29C70/58—Shaping composites, i.e. plastics material comprising reinforcements, fillers or preformed parts, e.g. inserts comprising fillers only, e.g. particles, powder, beads, flakes, spheres
    • B29C70/64—Shaping composites, i.e. plastics material comprising reinforcements, fillers or preformed parts, e.g. inserts comprising fillers only, e.g. particles, powder, beads, flakes, spheres the filler influencing the surface characteristics of the material, e.g. by concentrating near the surface or by incorporating in the surface by force
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y40/00—Manufacture or treatment of nanostructures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B32/00—Carbon; Compounds thereof
    • C01B32/15—Nano-sized carbon materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/258—Genetic materials, DNA, RNA, genes, vectors, e.g. plasmids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606—Coatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0061—Methods for using microneedles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2105/00—Condition, form or state of moulded material or of the material to be shaped
    • B29K2105/06—Condition, form or state of moulded material or of the material to be shaped containing reinforcements, fillers or inserts
    • B29K2105/16—Fillers
    • B29K2105/162—Nanoparticles

Abstract

The present invention relates to a nano-enhanced device for substance transfer between the device and a tissue. The device comprises a substrate with substantially aligned carbon nanotubes anchored within the substrate, and with at least one end of the carbon nanotubes protruding from the substrate. The protruding nanotube ends may be coated with a drug for delivery of the drug into body tissue. The present invention may be incorporated into an angioplasty catheter balloon or into a patch that is worn on the skin. The carbon nanotubes can be grouped in clusters to effectively form nano-needles which can transfer fluid to or from the subdermal tissue. The nano-needles can be used in conjunction with a sensor to ascertain body fluid information such as pH, glucose level, etc.

Description

Send and material Transfer by having the medicine that promotes from the nanometer enhanced device of the outstanding carbon nanotubes arranged of apparatus surface
Prioity claim
The application requires in the U.S. Provisional Application 61/206th of 01/27/2009 title of submitting to for " CARBONNANOTUBE-BASED DEVICE FOR SUB-DERMAL BLOOD AND FLUIDPROPERTY MONITORING (device based on CNT that is used for the monitoring of subcutaneous blood and fluid properties) ", No. 071 and in 05/19/2009 title of submitting to be " METHOD; DEVICE AND DESIGN FOR DELIVERY OF DRUGS BE ANANO-ENHANCED ANGIOPLASTY BALLOON (be used for method by the enhanced angioplasty air bag of nanometer delivering drugs; device and design) " the non-temporary patent application of rights and interests of priority of No. the 61/179th, 639, U.S. Provisional Application.
Invention field
The present invention relates to the enhanced medicine of nanostructured and send and the blood monitoring device, and relate more particularly to be used to promote the having of medicine between device and bodily tissue or fluid transmission from the device of the outstanding carbon nanotubes arranged of apparatus surface.
Background of invention
Microvasculature in hypodermic layer if can touch, provides the healthy life information about measured individual.For example, blood sugar level, oxygen content, hormone concentration or the like can directly be measured from blood properties.Frequently, in order to obtain this information, skin must be by needle-penetration with in the blood suction sampler.The risk of the infection that the use of such pin usually causes to the exposure of environment or owing to breaking of skin with pain, blood is associated.The alternative form of a kind of Wicresoft of this program is that pick off is embedded in the hypodermic layer.In addition, the program of this acquisition implant (depending on scale) is problematic, this be since place the process of implant and the potential repulsion that produces by patient's body both.
Another field relevant with theme of the present invention is in the angioplasty program.Percutaneous transluminal angio plasty (PTA) and percutaneous transluminal coronary angioplasty (PTCA) are the methods that is used for opening again in Wicresoft's mode tremulous pulse narrow or that stop up that established, the process proof.Air bag is used in the narrow sections that conduit is placed on tremulous pulse and is inflated the diameter that reaches its expectation up to inner chamber then.The narrow part of using expansible air bag to open tremulous pulse forcibly needs very high pressure (15bar) and is tending towards causing damage to blood vessel wall.Health is a hyper-proliferative to the natural response of such damage, promptly fissional unusual high speed, the function that it causes the inner chamber stricturization and therefore reduces blood vessel.This plays opposite effect with the initial purpose of opening tremulous pulse narrow or that stop up.
For to anti-angiogenic hyper-proliferative response, can use antiproliferative taxane medicine, for example paclitaxel.Low dose of paclitaxel demonstrates with contacting of the short time of the single of tissue and suppresses local cells propagation.Paclitaxel is the mitotic inhibitor of using in the cancer chemotherapy of being everlasting, because cancerous cell shows hyper-proliferative.Paclitaxel primitively derives from the bark of Pacific yew tree, but is produced by the other biological engineering method now.The mechanism of action of paclitaxel is passing through and the bonded stabilisation of tubulin of microtubule, thereby disturbs their the normal decomposition during cell division.This has the net effect that reduces cell division speed, and resists hyper-proliferative.
The antiproliferative taxane has the critical nature of the hyper-proliferative response that is used to minimize impaired blood vessel wall.They have high lipophile (hydrophobicity) and closely are incorporated into various cell component, give to keep in the good part at site of delivery place.Though hydrophilic compounds easily infiltrates through in the tissue, they are also promptly removed.Paclitaxel is hydrophobic compound and is diffused in the arterial wall No. the 1st, document (see reference) by the inner chamber at the place of sending by it.
The exemplary program that is used for the treatment of tremulous pulse narrow or that stop up is to use the angioplasty air bag of paclitaxel coating, and wherein paclitaxel plays a part to suppress hyper-proliferative after the airbag-releasing process.Major limitation to this process is as follows:
1. needing long inflationtime, is enough to guarantee paclitaxel to the diffusion of arterial wall, and this may cause over-drastic arterial wall damage.Studies show that in the past for about 90% of the predose of paclitaxel is passed to arterial wall, needs 40-60 minute No. the 1st, document (see reference);
2. in order to obtain the benefit of the optimum that hyper-proliferative suppresses, importantly, the paclitaxel clad can not lost or wash off when advancing the narrow sections that enters tremulous pulse by blood flow.Studies show that in the past, paclitaxel by blood flow never the speed washed off of inflatable air bag be high 1.2% per minute No. the 2nd, document (see reference) to predose;
3. the potential loss of paclitaxel clad, this is owing to contact with the arterial wall of health when advancing the narrow sections that enters tremulous pulse; And
4. the maximal dose that can be applied to the paclitaxel on the single air bag is about 11mg (10 μ g/mm 2), this is significantly less than by the dose of paclitaxel for taxol of FDA approval No. the 1st, document (see reference).
Should be noted that the purposes of purpose of material character that CNT is used to strengthen balloon catheter at United States Patent (USP) the 7th, 037, propose in No. 562.Yet, in this patent, be not to be used for medicine to send the matrix material of purpose and mix with the purpose that is used for reinforcement material with CNT.In addition, CNT makes device inoperative to this purpose not by so that they will be given prominence to from the surface and the mode that promotes medicine to send is arranged or partly is anchored at the matrix material.
Therefore; continue to exist the fluid that protection is extracted out to avoid the demand of Wicresoft's blood monitoring device of atmospheric pressure, and also continue to exist and in the period of lacking relatively, be delivered to the position that is affected and minimum drug loss demand effectively to the drug delivery system of the body fluid of process to medicine that can a large amount of expectations.
The tabulation of the list of references of being quoted
In whole the application, quote following list of references.For clear and convenient, list of references is listed in this article, as the person's of readding center resources.Following list of references is incorporated into way of reference at this, as fully being included in herein.List of references is by being quoted in this application with reference to corresponding list of references number.
(1) Creel, C.J., M.A.Lovich and E.R.Edelman, Arterial paclitaxel distribution and deposition (the tremulous pulse paclitaxel distributes and deposition) .Circulation Research, 2000,86 (8): the 879-884 page or leaf.
(2) Scheller, B., U.Speck, C.Abramjuk, U.Bernhardt, M.Bohm and G.Nickenig, Paclitaxel balloon coating, a novel method for prevention and therapy of restenosis (paclitaxel air bag clad, a kind of prevention that is used for restenosis of novelty and the method for treatment) .Circulation, 2004.110 (7): the 810-814 page or leaf.
(3) Bronikowski, M.J., Longer nanotubes at lower temperatures:The influence of effective activation energies on carbon nanotube growth by thermal chemical vapor deposition (at the longer nanotube of lower temperature: effectively activation energy is to the influence by the thermal chemical vapor deposition carbon nanotubes grown) .Journal of Physical Chemistry C, 2007.111 (48): the 17705-17712 page or leaf.
Summary of the invention
The present invention relates to the nanometer enhanced device, it is used for the material Transfer between device and the tissue.In one aspect, device comprises base material and the array of the CNT with two ends arranged substantially, CNT be anchored in the base material and at least one end outstanding from base material, the material Transfer ability of Tu Chu CNT intensifier thus.
Aspect another of device, the material of the group of selected free drug of carbon nano pipe array and genomic constitution coats.
Aspect another of device, do not had coating medicine and medicine by the outstanding end of the CNT of anchoring and coat the zone and form by the zone that is selected from the group of forming by the sidewall of CNT and the free space between CNT.
In yet another aspect, type of device is selected from the group of being made up of angioplasty air bag and stand-by organizationally patch.
Aspect device other, coating medicine is a paclitaxel.
Aspect another of device, medicine strengthens from the method for sending by being selected from by the following group of forming of device to tissue: to the direct or indirect heating of at least a portion of carbon nano pipe array, make at least a portion by carbon nano pipe array of electric current, to mechanical vibration of at least a portion of the ultrasound wave on the laser stimulation of at least a portion of carbon nano pipe array or other optical stimulation, at least a portion, carbon nano pipe array and the hydrophobicity that changes nano-tube array during manufacture at carbon nano pipe array.
In yet another aspect, medicine is sent enhancing and is performed in the time that is selected from by the following group of forming: immediately with according to timing routine.
Aspect another of device of the present invention, CNT is arranged to one or more clusters, makes the effect of withdrawal of needle effectively of each cluster.
The device another aspect, base material comprises porous material, thus material can be passed to by the inherent capillarity of CNT device and tissue or by from the device and organized delivery.
In yet another aspect, the porous substrate material load remains to be passed to by CNT the material of tissue.
Aspect another of device, carbon nano tube cluster is so that carbon nano tube cluster is patterned by mode electrically isolated from one, and wherein device also comprises the pick off of the electromotive force that is used to read the nanotube cluster.
In yet another aspect, the inherent electrical conductivity of CNT changes by the chemical treatments CNT with precoating.
Of the present invention other aspect, the subclass of carbon nano tube cluster (subset) is handled with glucoseoxidase, and another subclass of CNT handles with the iron cyanide, can be implemented and allow the measurement of blood sugar level thus by the conduction of blood.
The accompanying drawing summary
In conjunction with reference to the following drawings, from the following detailed description to various aspects of the present invention, purpose of the present invention, feature and advantage will be significantly, in the accompanying drawings:
Fig. 1 is the side view that has from the polymer anchor layer of its outstanding CNT;
Fig. 2 A is the side view according to nanometer enhanced device of the present invention, and only end of having described CNT is outstanding from base material;
Fig. 2 B is the side view according to nanometer enhanced device of the present invention, described the surface that device punctures tissue;
Fig. 3 A is the side view according to nanometer enhanced device of the present invention, has described CNT and has been coated by medicine or agent;
Fig. 3 B is the side view according to nanometer enhanced device of the present invention, and the interior section of having described carbon nano pipe array is coated by medicine, but nanotube ends is retained and does not have coating medicine;
Fig. 4 A is the side view that is anchored at the nanoneedle in the porous substrate material according to of the present invention;
Fig. 4 B is the side view that has from the device of its outstanding multiple nanoneedle;
Fig. 5 A is connected in the side view of pick off with the nanometer enhanced device of formation nano-probe;
Fig. 5 B is the vertical view according to nano-probe device of the present invention, and wherein the nanoneedle cluster is patterned as electric isolated subclass;
Fig. 6 A shows the diagram according to the enhanced catheter air bag of nanometer of the present invention, and wherein air bag is in the deflated state;
Fig. 6 B shows the diagram according to the enhanced catheter air bag of nanometer of the present invention, and wherein air bag is in the swelling state;
Fig. 7 A is the perspective view of the enhanced epidermis patch of nanometer according to the present invention; And
Fig. 7 B shows the diagram of the enhanced epidermis patch of the nanometer that is attached on the arm of user.
Describe in detail
The present invention relates to the enhanced medicine of nanostructured and send and the blood monitoring device, and relate more particularly to be used to promote the having of medicine between device and bodily tissue or fluid transmission from the device of the outstanding carbon nanotubes arranged of apparatus surface.Following description is presented so that those of ordinary skill in the art can make and use the present invention and it can be incorporated in the situation of specific application.Various modifications, and the multiple use in different application will be easy to understand for a person skilled in the art, and the General Principle of this paper definition can be applied to various embodiments.Therefore, the present invention is not intended to be restricted to the embodiment that is presented, but will meet and principle disclosed herein and novel characteristics the wideest consistent scope.
In the following detailed description, illustrated multiple concrete details, understand more completely of the present invention to provide.Yet, will be apparent that to those skilled in the art the present invention can be implemented, and not necessarily is limited to these concrete details.In other cases, the construction and device of knowing is by with the form of block diagram but not at length illustrate, to avoid fuzzy the present invention.
The person's of readding attention be directed to submit to simultaneously with this description and check all papers and the document of opening to the public jointly with this description, and the content of all such papers and document is all incorporated into this paper with way of reference.Disclosed all features can be played identical, alternative features replacement equivalence or similar purpose in this description (comprising any claim of following, summary and accompanying drawing), unless clearly state in addition.Therefore, unless clearly state in addition, disclosed each feature all only is an example of feature equivalence or similar of a universal serial.
In addition, any key element that is used for carrying out " means " of concrete function or is used to carry out " step " of concrete function of the statement ambiguously in the claim should not be interpreted as 35U.S.C. the 112nd section of " means " of stipulating of the 6th joint or " step " clause.Especially, the use of " step " in this paper claim or " behavior " is not intended to call the clause of the 112nd section at 35U.S.C. the 6th joint.
(1) foreword
The present invention relates to the enhanced medicine of nanostructured and send and the blood monitoring device, and relate more particularly to be used to promote the having of medicine between device and bodily tissue or material Transfer from the device of the outstanding carbon nanotubes arranged of apparatus surface.
The latest developments of carbon nanotube technology make to create to have at the diameter of nanometer (nm) order of magnitude with at the pin or the rod of the length of millimeter magnitude becomes possibility.CNT is useful in this application because neural in skin corium distribution with have that to compare similar in appearance to the nanoscale pin of the size of CNT be sparse.For example, closely 200 of contact aggregations with CNT of 10nm diameter will make whole aggregation occupy overall diameter less than 2 microns.U.S. Patent Application Publication has been described for 2008/0145616A1 number and has been used for the optionally method of a large amount of nano-scale structures of anchoring.This anchoring process allows control that the degree of depth in the other materials is gone in the nano-scale structures anchoring.
(2) details of the present invention
CNT can form in many ways, and the simplest mode is to use the thermal chemical vapor deposition of the base material of catalyst coating.Usually, the ferrum of several nanometers is coated to silicon, is prepared in advance and for example is placed in the tube furnace under the ethylene at the carbon raw material air-flow, and be warming up to suitable temperature, for example 725 degrees centigrade.The thermal chemical vapor deposition of CNT growth No. the 3rd, document (see reference) is created on the carbon nanotubes arranged vertically on the growth base material, and the growth base material is silicon normally.
With the array of CNT be anchored on the base material can be by making CNT array contact with uncured polymer material layer and experience curing schedule then and carry out, as what in U.S. Patent Application Publication the 2008/0145616th A1 that above quotes number, describe.In order the CNT anchoring to be gone into the tubulose base material for example in the bag material, can use around center bar to keep the sacrificial release layers of cylinder form.At first, sacrificial release layers is deposited and becomes and curing as much as possible around clavate, and bag material deposits around releasing layer then.Nanotube is attached into or anchoring is gone in the bag material then.At last, sacrificial release layers is removed, and discharges to have to be attached into or the air bag of nanotube is wherein gone in anchoring.
Before or after CNT was attached to base material, medicine, gene or other materials can be coated to CNT in another step.This is feasible especially when using drug taxol, because paclitaxel is hydrophobic, and CNT also is hydrophobic in their growth conditions.Therefore, the paclitaxel molecule will preferentially be attached to CNT, up to CNT be placed as with blood vessel in plugging material closely contact, plugging material normally fatty and be hydrophobic in itself.In addition, because carbon nano tube surface is hydrophobic in itself, so remain in water and aqueous solution and mixture, for example blood that the interior any material of layer of nanotube will be exempted the contact nanometer tube-surface.Therefore, aspect expectation of the present invention, the end of CNT is retained does not have the pharmaceutical pack coating, and the pharmaceutical pack coating is limited to the sidewall of nanotube and/or the free space between nanotube.This aspect provides the safe surface contact and avoids medicine is released in non-destination organization or the body fluid too early.
Can strengthen by combining by the drug release of CNT in destination organization with the intensifier that can carry out multiple Enhancement Method, Enhancement Method includes but not limited to one or more in following are applied to CNT: direct or indirect heating, for example by electromagnetic radiation such as radio frequency (RF) ripple; Electric current; Laser or other optical stimulation; Ultrasound wave; Mechanical vibration; And hydrophobicity (this can for example be undertaken by the use oxygen plasma treatment) by changing nano-tube array during manufacture.These Enhancement Method can be applied to the set partially or completely of the spatial patterned of CNT.Method can also be applied immediately or according to timing routine.
Fig. 1 shows the diagram of general embodiment of the present invention.Device comprises substrate layer 100 and a plurality of carbon nanotubes arranged substantially 102.Each CNT has two ends 104, and CNT 102 is anchored in the base material 100, and at least one end 104 is outstanding from base material.Shown in example in, two ends of CNT 102 are outstanding from base material 100.
Fig. 2 A illustrates another embodiment of device, and wherein only end 104 of carbon nanotubes arranged 102 is outstanding from base material 100.The end 104 that Fig. 2 B shows carbon nano pipe array 102 punctures for example surface of skin, arterial wall, colon or the like of bodily tissue 200.Should be noted that the present invention also has the potential purposes outside medical domain.Device can be feasiblely to all types of target transmitter substance except bodily tissue, and therefore is not restricted to application above.
CNT can or wait that other materials that are passed to tissue coat by medicine, gene.Fig. 3 A illustrates the embodiment that CNT 102 is waited to be passed to the device of systemic material 300 coatings.In the selectable embodiment as shown in Fig. 3 B, the end 104 of CNT is retained does not have the material 300 of coating.Coat material 300, in this case, will be limited to the sidewall of CNT and/or the space between CNT.
(3.0) the concrete application
(3.1) pin
One aspect of the present invention is to use the patterned distribution of CNT to play the device of minute yardstick pin, and the minute yardstick pin can easily pierce through skin corium, arrives microvasculature or pore-fluid.Such device can be used as pin or oppositely pin (reverse needle) to promote material respectively to the transmission of health with from the transmission of health.The group that Fig. 4 A shows CNT 102 is gone into to make in the base material 100 them to form nanoneedle by anchoring.In the embodiment illustrated, base material is porous 400.Two-sided arrow 402 show material by CNT 102 to base material or from the possible direction of base material migration.When the time spent of doing of withdrawal of needle, blood or pore-fluid are drawn in the porous substrate 400 with fluidic subcutaneous the contact by the pin based on CNT, and described subcutaneous contact is similar in appearance to the behavior that punctures shown in Fig. 2 B.Fluidic analysis is undertaken by some independent methods, for example by optical analysis.In order to play reverse pin, porous substrate 400 uses for example medicine preload of some agent, can be sent in the subcutaneous area by the pin based on CNT for described then dose.Fig. 4 B shows the device of the multiple needle-like cluster with nanotube 102.
(3.2) probe
The nanoneedle device can be used to monitor for example effect of the probe of pH, sugar level, oxygen content or the like of blood sugar level or other blood or body fluid character to play with sensor combinations.Device works based on the inherent electrical conductivity of CNT.Fig. 5 A is the diagram according to nano-probe of the present invention.Probe comprise be anchored at pick off 500 bonded base materials 100 in one or more CNTs 102 clusters.Pick off operably is connected in CNT 102 or is connected in base material 100, or the two, this depends on the operator scheme of expectation.In Fig. 5 A, be connected in to pick off 500 behaviour's property CNT 102 clusters.In the embodiment of the expectation as shown in the vertical view among Fig. 5 B, the nanotube cluster is so that they are patterned by mode electrically isolated from one.Shown pattern comprises the internal ring 502 and the outer shroud 504 of nanotube cluster.A concrete purposes of the aspect shown in Fig. 5 B is a measurement of glucose levels.In this is used, the subclass of carbon nano tube cluster (for example internal ring 502) is handled by glucoseoxidase, and another subclass of carbon nano tube cluster (for example outer shroud 504) is handled by the iron cyanide, can be implemented and allow the measurement of blood sugar level thus by the conductivity of blood.Should be noted that the present invention can adopt the pattern of the many nanotube clusters except the specific embodiment shown in Fig. 5 B.In addition, device can also be as the probe that coats, wherein can be coated in advance to the surface of CNT or in the CNT, as shown in Fig. 3 A and Fig. 3 B, and therefore sent and be released in the bodily tissue by penetrating of CNT such as the agent of medicine.
(3.3) painting brush thing
The assembly of the CNT as shown in Fig. 4 B can also serve as wet paint brush thing by means of the inherent capillarity of CNT.Similar methods is described in No. the 11/124th, 523, U.S. Patent application, and it is incorporated into way of reference in view of the above, as intactly illustrating in this article.
(3.4) angioplasty air bag
The embodiment of another expectation of the present invention is to be used for the delivering drugs paclitaxel to prevent histiocytic hyper-proliferative after the inflation of air bag is with a part of opening blood vessel in the angioplasty program.Yet the present invention should not be construed as limited to the use in the angioplasty program or be limited to sending of paclitaxel.The present invention can be used for sending miscellaneous material to the each several part of health feasiblely, the gastrointestinal each several part that the each several part of health includes but not limited to skin, uterus, bronchus and comprises colon.
Fig. 6 A and Fig. 6 B illustrate the enhanced angioplasty air bag 600 of nanometer according to the present invention.Fig. 6 A shows the angioplasty air bag with the venting form, will be inserted in blood vessel or other health encapsulation object as it.When inflation, shown in Fig. 6 B, surface carbon nanotube 102 is gone into any drug release that coats thereon in the destination organization with the mode piercing blood vessel surface shown in Fig. 2 B.
The present invention, aspect the purposes in the angioplasty air bag, overcome restriction as the correlation technique of in background parts above, describing, these restrictions comprise long inflationtime, because the minimizing of the available medication amount that loss during insertion process causes, to too early the sending and/or the sending and low total delivering drugs amount of non-expectation of health tissues.Because the possible amount of the medicine that is used to send depends on surface area, but so the enhanced air bag-conduit of nanometer will keep bigger medication amount during insertion and increase maximum delivering drugs amount with the factor of 1000 times the order of magnitude, similar to the increase of the surface area that provides by nanostructured.
Following expression formula has compared enhanced air bag of nanometer and the surface area that does not have the enhanced standard air bag of nanometer:
Figure BDA0000078209870000111
Wherein:
D (106 among Fig. 1) is the diameter of single carbon nanotube;
H (108 among Fig. 1) is the length of single carbon nanotube;
S (110 among Fig. 1) is the distance between single carbon nanotube;
R (604 among Fig. 6 B) is the radius of air bag; And
L (602 among Fig. 6 A) is the length of air bag, and
Use the representative value of following supposition:
d＝10nm；
S=100nm; And
h＝500nm，
Obtain following result:
Figure BDA0000078209870000112
This result shows that the diffusion into the surface enhancing of catheter air bag can easily increase by 10 with surface area as described 3The factor.
(3.5) epidermis patch
The enhanced surface of nanometer of the present invention can be incorporated into the epidermis patch of waiting to be used on the skin.Fig. 7 A illustrates the example of the enhanced epidermis patch 700 of nanometer.Patch has from waiting to be attached to the outstanding carbon nanotubes arranged 102 in surface of skin.The part of patch 700, for example periphery 702 can be coated by binding agent, is beneficial to the adhesion to skin.When patch 700 is applied to skin, in Fig. 7 B, CNT 102 will enter skin and any medicine or the agent that will coat thereon are released in the skin in the mode shown in Fig. 2 B.Patch can be used in combination with in the embodiment that pro-of the present invention is described any.

Claims (13)

1. a nanometer enhanced device is used for the material Transfer between described device and the tissue, comprising:
Base material; And
The array of the CNT with two ends of Pai Lieing substantially, described CNT be anchored in the described base material and at least one end outstanding from described base material, Tu Chu CNT strengthens the material Transfer ability of described device thus.
2. device according to claim 1, the material of the group of selected free drug of wherein said carbon nano pipe array and genomic constitution coats.
3. device according to claim 2, wherein said CNT has sidewall and wherein said nano-tube array and contains free space between described CNT, and wherein the outstanding end of the CNT of institute's anchoring does not have the coating material, and material coating zone is made up of the zone that is selected from the group of being made up of the sidewall and the free space between described CNT of described CNT.
4. device according to claim 2, wherein said device are selected from by the angioplasty air bag and wait to be used in the group that described structural patch is formed.
5. device according to claim 4, wherein said medicine is a paclitaxel.
6. device according to claim 2, wherein said medicine are from described device sending by sending intensifier by the medicine of the enhancing behavior of the following group of forming and combine and strengthen with can being selected to described tissue: to the direct or indirect heating of at least a portion of described carbon nano pipe array, make electric current at least a portion by described carbon nano pipe array, laser stimulation or other optical stimulation at least a portion of described carbon nano pipe array, ultrasound wave at least a portion of described carbon nano pipe array, mechanical vibration of at least a portion of described carbon nano pipe array and the hydrophobicity that changes described nano-tube array during manufacture.
7. device according to claim 6, wherein said medicine are sent intensifier and are carried out described enhancing behavior being selected from by the time of the following group of forming: immediately with according to timing routine.
8. device according to claim 1, wherein said CNT is arranged to one or more clusters, makes the effect of withdrawal of needle effectively of each cluster.
9. device according to claim 8, wherein said base material comprises porous material, material can be passed to described device and described tissue by the inherent capillarity of described CNT or by from described device and described organized delivery thus.
10. device according to claim 9, wherein the porous substrate material load remains to be passed to by described CNT the material of described tissue.
11. device according to claim 8, the cluster of wherein said CNT is so that the cluster of described CNT is patterned by mode electrically isolated from one, and wherein said device also comprises the pick off of the electromotive force of the cluster that is used to read described nanotube.
12. device according to claim 11, wherein said CNT has inherent electrical conductivity, and the described inherent electrical conductivity of wherein said CNT is by changing with the described CNT of the chemical treatments of precoating.
13. device according to claim 12, one subclass of the cluster of wherein said CNT is handled with glucoseoxidase, and another subclass of described CNT is handled with the iron cyanide, can be implemented and allow the measurement of blood sugar level thus by the conduction of blood.
CN2010800053668A 2009-01-27 2010-01-27 Drug delivery and substance transfer facilitated by nano-enhanced device having aligned carbon nanotubes protruding from device surface Pending CN102292114A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US20607109P 2009-01-27 2009-01-27
US61/206,071 2009-01-27
US17963909P 2009-05-19 2009-05-19
US61/179,639 2009-05-19
PCT/US2010/000243 WO2010087971A2 (en) 2009-01-27 2010-01-27 Drug delivery and substance transfer facilitated by nano-enhanced device having aligned carbon nanotubes protruding from device surface

Publications (1)

Publication Number Publication Date
CN102292114A true CN102292114A (en) 2011-12-21

Family

ID=42236746

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2010800053668A Pending CN102292114A (en) 2009-01-27 2010-01-27 Drug delivery and substance transfer facilitated by nano-enhanced device having aligned carbon nanotubes protruding from device surface

Country Status (5)

Country Link
US (3) US20100196446A1 (en)
EP (1) EP2381972A2 (en)
JP (1) JP5620408B2 (en)
CN (1) CN102292114A (en)
WO (1) WO2010087971A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108969869A (en) * 2018-07-01 2018-12-11 刘征宇 Sacculus of controllable formula of internal flow reduction ischemia reperfusion injury

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7959969B2 (en) 2007-07-10 2011-06-14 California Institute Of Technology Fabrication of anchored carbon nanotube array devices for integrated light collection and energy conversion
WO2010008627A1 (en) * 2008-03-28 2010-01-21 Georgia Tech Research Corporation Electrode arrays and methods of making and using same
EP2381972A2 (en) 2009-01-27 2011-11-02 California Institute Of Technology Drug delivery and substance transfer facilitated by nano-enhanced device having aligned carbon nanotubes protruding from device surface
CN102740800A (en) * 2010-01-29 2012-10-17 爱尔康医药有限公司 Biodegradable protrusions on inflatable device
US9115424B2 (en) 2010-04-07 2015-08-25 California Institute Of Technology Simple method for producing superhydrophobic carbon nanotube array
AU2011246879C1 (en) 2010-04-28 2016-03-24 Sorrento Therapeutics, Inc. Device for delivery of rheumatoid arthritis medication
CN102985131B (en) 2010-04-28 2016-06-29 金伯利-克拉克环球有限公司 For delivering the medical treatment device of siRNA
AU2011311255B2 (en) 2010-04-28 2015-10-08 Sorrento Therapeutics, Inc. Method for increasing permeability of an epithelial barrier
AU2011288209C1 (en) 2010-04-28 2016-03-24 Kimberly-Clark Worldwide, Inc. Injection molded microneedle array and method for forming the microneedle array
US8784373B2 (en) * 2010-09-02 2014-07-22 California Institute Of Technology Drug delivery by carbon nanotube arrays
WO2012079066A2 (en) 2010-12-10 2012-06-14 California Institute Of Technology Method for producing graphene oxide with tunable gap
CA2834697A1 (en) 2010-12-14 2012-06-21 Molecular Rebar Design Llc Improved elastomer formulations
US8976507B2 (en) 2011-03-29 2015-03-10 California Institute Of Technology Method to increase the capacitance of electrochemical carbon nanotube capacitors by conformal deposition of nanoparticles
US20170246439A9 (en) 2011-10-27 2017-08-31 Kimberly-Clark Worldwide, Inc. Increased Bioavailability of Transdermally Delivered Agents
WO2013061208A1 (en) 2011-10-27 2013-05-02 Kimberly-Clark Worldwide, Inc. Transdermal delivery of high viscosity bioactive agents
WO2013090844A1 (en) 2011-12-14 2013-06-20 California Institute Of Technology Sharp tip carbon nanotube microneedle devices and their fabrication
WO2014022314A1 (en) 2012-07-30 2014-02-06 California Institute Of Technology Nano tri-carbon composite systems and manufacture
US20140094900A1 (en) * 2012-10-01 2014-04-03 Brigham Young University Compliant biocompatible device and method of manufacture
GB201304669D0 (en) * 2013-03-15 2013-05-01 Univ Singapore Micro-needles integrated with nanotubes
US20140296780A1 (en) * 2013-04-01 2014-10-02 California Institute Of Technology Polymer composite carbon nanotube microneedle devices and their fabrication
US20150182703A1 (en) * 2013-12-02 2015-07-02 Biltmore Technologies, Inc. Nanofluidic delivery system
WO2015103214A1 (en) * 2013-12-30 2015-07-09 Molecular Rebar Design, Llc Transdermal patches with discrete carbon nanotubes
EP3218934A4 (en) * 2014-11-13 2018-06-20 Neem Scientific Inc. Large scale, low cost nanosensor, nano-needle, and nanopump arrays
WO2016077804A1 (en) * 2014-11-13 2016-05-19 Neem Scientific, Inc. Large scale, low cost nanosensor, nano-needle, and nanopump arrays
US10517903B2 (en) 2015-09-14 2019-12-31 Amnio Technology Llc Amnion derived therapeutic composition and process of making same
AU2019256527A1 (en) 2018-04-19 2020-11-12 Spiral Therapeutics, Inc. Inner ear drug delivery devices and methods of use
CN109011130A (en) * 2018-05-29 2018-12-18 上海大学 A kind of percutaneous photoelectricity driving ion medicine conveying device based on nanoneedle
WO2021053631A2 (en) * 2019-09-21 2021-03-25 Abdolahad Mohammad Electrostatic drug delivery
CN111991840A (en) * 2020-08-26 2020-11-27 恒天(厦门)健康产业发展有限公司 Process for preparing nano Chinese medicine
KR102566813B1 (en) * 2021-09-02 2023-08-11 서울대학교산학협력단 Neural multifunctional device and method of manufacturing the same
WO2023107950A1 (en) * 2021-12-06 2023-06-15 Case Western Reserve University Implant medical devices

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005334594A (en) * 2004-05-27 2005-12-08 I-Com:Kk Medication patch with carbon nanotube protrusion
US20060093642A1 (en) * 2004-11-03 2006-05-04 Ranade Shrirang V Method of incorporating carbon nanotubes in a medical appliance, a carbon nanotube medical appliance, and a medical appliance coated using carbon nanotube technology
US20070066934A1 (en) * 2005-09-19 2007-03-22 Transport Pharmaceuticals, Inc. Electrokinetic delivery system and methods therefor
US20070207182A1 (en) * 2006-03-06 2007-09-06 Jan Weber Medical devices having electrically aligned elongated particles
CN101101273A (en) * 2007-06-29 2008-01-09 浙江大学 Carbon nano tube modified blood sugar biosensor
CN101126735A (en) * 2007-09-30 2008-02-20 董益阳 Biosensor and its preparation method and detection method using said biosensor
CN101181989A (en) * 2007-11-20 2008-05-21 浙江大学 Acid choline biomimetic polymers coated carbon-nano tube and preparation method thereof

Family Cites Families (109)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3964482A (en) 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
IT1220172B (en) 1987-07-17 1990-06-06 Il Consiglio Nazionale Delle R FIBER OPTIC DEVICE FOR THE TRANSMISSION AND LATERAL IRRADIATION OF LASER ENERGY, PARTICULARLY FOR ANGIOPLASTIC TREATMENTS
US5116317A (en) 1988-06-16 1992-05-26 Optimed Technologies, Inc. Angioplasty catheter with integral fiber optic assembly
US5109046A (en) 1991-02-28 1992-04-28 Atochem North America, Inc. Liquid organotinthioalkanol stabilizer compositions and vinyl halide resin compositions containing the same
CH685506A5 (en) 1993-06-23 1995-07-31 Zellweger Uster Ag Device for measuring the mass or substance cross-section of slivers and use of the device.
US6734451B2 (en) * 1993-11-02 2004-05-11 Matsushita Electric Industrial Co., Ltd. Aggregate of semiconductor micro-needles and method of manufacturing the same, and semiconductor apparatus and method of manufacturing the same
US5457041A (en) * 1994-03-25 1995-10-10 Science Applications International Corporation Needle array and method of introducing biological substances into living cells using the needle array
WO1996021938A1 (en) 1995-01-13 1996-07-18 The General Hospital Corporation Video-rate confocal scanning laser microscope
US6503231B1 (en) 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
JP2002537579A (en) 1999-02-17 2002-11-05 ルーシド インコーポレーテッド Tissue specimen holder
US6720547B1 (en) 1999-03-18 2004-04-13 Lucid, Inc. System and method for enhancing confocal reflectance images of tissue specimens
US6611707B1 (en) 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
US6256533B1 (en) 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6379324B1 (en) 1999-06-09 2002-04-30 The Procter & Gamble Company Intracutaneous microneedle array apparatus
US6312612B1 (en) 1999-06-09 2001-11-06 The Procter & Gamble Company Apparatus and method for manufacturing an intracutaneous microneedle array
AUPQ304199A0 (en) 1999-09-23 1999-10-21 Commonwealth Scientific And Industrial Research Organisation Patterned carbon nanotubes
US6551849B1 (en) * 1999-11-02 2003-04-22 Christopher J. Kenney Method for fabricating arrays of micro-needles
US7335603B2 (en) 2000-02-07 2008-02-26 Vladimir Mancevski System and method for fabricating logic devices comprising carbon nanotube transistors
EP1311310A4 (en) 2000-08-21 2004-11-24 Cleveland Clinic Foundation Microneedle array module and method of fabricating the same
US6533949B1 (en) * 2000-08-28 2003-03-18 Nanopass Ltd. Microneedle structure and production method therefor
DE10051910A1 (en) 2000-10-19 2002-05-02 Membrana Mundi Gmbh Flexible, porous membranes and adsorbents, and processes for their manufacture
US8029734B2 (en) 2001-03-29 2011-10-04 The Board Of Trustees Of The Leland Stanford Junior University Noncovalent sidewall functionalization of carbon nanotubes
TW554388B (en) * 2001-03-30 2003-09-21 Univ California Methods of fabricating nanostructures and nanowires and devices fabricated therefrom
US6686299B2 (en) * 2001-06-21 2004-02-03 Carlo D. Montemagno Nanosyringe array and method
US6749792B2 (en) 2001-07-09 2004-06-15 Lifescan, Inc. Micro-needles and methods of manufacture and use thereof
US7166266B2 (en) 2001-07-10 2007-01-23 Gb Tech, Inc. Isolation and purification of single walled carbon nanotube structures
US6730398B2 (en) * 2001-08-31 2004-05-04 Showa Denko K.K. Fine carbon and method for producing the same
US6689100B2 (en) * 2001-10-05 2004-02-10 Becton, Dickinson And Company Microdevice and method of delivering or withdrawing a substance through the skin of an animal
US6713519B2 (en) 2001-12-21 2004-03-30 Battelle Memorial Institute Carbon nanotube-containing catalysts, methods of making, and reactions catalyzed over nanotube catalysts
US7037562B2 (en) * 2002-01-14 2006-05-02 Vascon Llc Angioplasty super balloon fabrication with composite materials
US7147894B2 (en) 2002-03-25 2006-12-12 The University Of North Carolina At Chapel Hill Method for assembling nano objects
AU2003275311A1 (en) 2002-09-16 2004-04-30 Sung-Yun Kwon Solid micro-perforators and methods of use
CN1296994C (en) 2002-11-14 2007-01-24 清华大学 A thermal interfacial material and method for manufacturing same
EP1479738A1 (en) 2003-05-20 2004-11-24 DSM IP Assets B.V. Hydrophobic coatings comprising reactive nano-particles
US20050011858A1 (en) 2003-07-16 2005-01-20 Industrial Technology Research Institute Method for fabricating a hollow micro-needle array
US20070114658A1 (en) 2004-08-24 2007-05-24 Carlos Dangelo Integrated Circuit Micro-Cooler with Double-Sided Tubes of a CNT Array
JP4945888B2 (en) 2003-10-09 2012-06-06 富士ゼロックス株式会社 Composite and production method thereof
US7753888B2 (en) 2003-11-21 2010-07-13 The Regents Of The University Of California Method and/or apparatus for puncturing a surface for extraction, in situ analysis, and/or substance delivery using microneedles
US7459839B2 (en) 2003-12-05 2008-12-02 Zhidan Li Tolt Low voltage electron source with self aligned gate apertures, and luminous display using the electron source
TWI253467B (en) 2003-12-23 2006-04-21 Hon Hai Prec Ind Co Ltd Thermal interface material and method for making same
TWM253898U (en) 2004-03-05 2004-12-21 Harvatek Corp Packaging structure of photosensitive chip
JP4374464B2 (en) * 2004-03-10 2009-12-02 独立行政法人産業技術総合研究所 Biosensor
TWI299358B (en) 2004-03-12 2008-08-01 Hon Hai Prec Ind Co Ltd Thermal interface material and method for making same
JP4399581B2 (en) * 2004-03-23 2010-01-20 独立行政法人産業技術総合研究所 Biosensor
US20050238539A1 (en) 2004-04-01 2005-10-27 Gal Shafirstein Apparatus for automated fresh tissue sectioning
CN100383213C (en) 2004-04-02 2008-04-23 清华大学 Thermal interface material and its manufacturing method
CN100345472C (en) 2004-04-10 2007-10-24 清华大学 Thermal-interface material and production thereof
CN100370604C (en) 2004-04-15 2008-02-20 鸿富锦精密工业（深圳）有限公司 Heat interface material and its producing method
CN100389166C (en) 2004-04-29 2008-05-21 鸿富锦精密工业（深圳）有限公司 Thermal interface material and its production method
TWM256877U (en) 2004-05-03 2005-02-11 Chan San Glass Co Ltd The structure of glasses
EP1747576A2 (en) * 2004-05-05 2007-01-31 California Institute of Technology Capillary lithography of nanofiber arrays
US7611628B1 (en) 2004-05-13 2009-11-03 University Of Kentucky Research Foundation Aligned nanotubule membranes
CN1290764C (en) 2004-05-13 2006-12-20 清华大学 Method for producing Nano carbon tubes in even length in large quantities
US20080292840A1 (en) 2004-05-19 2008-11-27 The Regents Of The University Of California Electrically and thermally conductive carbon nanotube or nanofiber array dry adhesive
JP4621896B2 (en) 2004-07-27 2011-01-26 独立行政法人産業技術総合研究所 Single-walled carbon nanotube and method for producing the same
US7560036B2 (en) * 2004-08-05 2009-07-14 Apogee Technology, Inc. System and method for drug delivery and microfluidic applications using microneedles
US8696619B2 (en) * 2004-08-10 2014-04-15 Robert P. Schnall Drug delivery devices
US20060057388A1 (en) * 2004-09-10 2006-03-16 Sungho Jin Aligned and open-ended nanotube structure and method for making the same
US7279916B2 (en) 2004-10-05 2007-10-09 Nanoconduction, Inc. Apparatus and test device for the application and measurement of prescribed, predicted and controlled contact pressure on wires
JP2006114265A (en) 2004-10-13 2006-04-27 Sony Corp Manufacturing method of micro electron source device
US7627938B2 (en) 2004-10-15 2009-12-08 Board Of Regents, The Univeristy Of Texas System Tapered hollow metallic microneedle array assembly and method of making and using the same
US7097776B2 (en) 2004-10-22 2006-08-29 Hewlett-Packard Development Company, L.P. Method of fabricating microneedles
US7785459B2 (en) 2004-10-22 2010-08-31 Hewlett-Packard Development Company, L.P. Microneedles and methods of fabricating
US8021967B2 (en) * 2004-11-01 2011-09-20 California Institute Of Technology Nanoscale wicking methods and devices
US20080009801A1 (en) 2004-12-02 2008-01-10 Nickel Janice H Method for dispensing material into a drug delivery device
JP2006164835A (en) 2004-12-09 2006-06-22 Sony Corp Micro electron source device and flat display device
US7850645B2 (en) * 2005-02-11 2010-12-14 Boston Scientific Scimed, Inc. Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power
US8048028B2 (en) 2005-02-17 2011-11-01 Boston Scientific Scimed, Inc. Reinforced medical balloon
CN1837147B (en) 2005-03-24 2010-05-05 清华大学 Thermal interface material and its production method
CN100337981C (en) 2005-03-24 2007-09-19 清华大学 Thermal interface material and its production method
WO2006107998A2 (en) 2005-04-05 2006-10-12 Pettit John W High-reliability optical fiber having a nanocomposite coating
TWI253898B (en) 2005-04-08 2006-04-21 Hon Hai Prec Ind Co Ltd Thermal interface material and method of making the same
CN100404242C (en) 2005-04-14 2008-07-23 清华大学 Heat interface material and its making process
CN100358132C (en) 2005-04-14 2007-12-26 清华大学 Thermal interface material producing method
TWI256877B (en) 2005-04-15 2006-06-11 Hon Hai Prec Ind Co Ltd Thermal interface material and method of making the same
US8043250B2 (en) 2005-05-18 2011-10-25 Nanomed Devices, Inc. High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances
US8048017B2 (en) 2005-05-18 2011-11-01 Bai Xu High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances
US20080269666A1 (en) 2005-05-25 2008-10-30 Georgia Tech Research Corporation Microneedles and Methods for Microinfusion
CN100454526C (en) 2005-06-30 2009-01-21 鸿富锦精密工业（深圳）有限公司 Thermo-interface material producing method
TWI263288B (en) 2005-07-06 2006-10-01 Powerchip Semiconductor Corp Method for fabricating conductive line
US7649665B2 (en) 2005-08-24 2010-01-19 The Trustees Of Boston College Apparatus and methods for optical switching using nanoscale optics
DE102005042367B4 (en) 2005-09-07 2009-11-12 Leica Microsystems Cms Gmbh Apparatus for generating 3-D images of a sample
US9283314B2 (en) 2005-09-21 2016-03-15 Abiomed, Inc. Cannula systems
FI120195B (en) 2005-11-16 2009-07-31 Canatu Oy Carbon nanotubes functionalized with covalently bonded fullerenes, process and apparatus for producing them, and composites thereof
US20070191766A1 (en) * 2006-02-10 2007-08-16 Boston Scientific Scimed, Inc. Balloon catheter having nanotubes
CN101054467B (en) 2006-04-14 2010-05-26 清华大学 Carbon nano-tube composite material and preparation method thereof
JP5771873B2 (en) 2006-05-04 2015-09-02 エルジー・ケム・リミテッド High-capacity / high-power electrochemical energy storage element using conductive (conductive) polymer composite
US20070276330A1 (en) 2006-05-28 2007-11-29 Beck Patricia A Microneedles and methods of fabricating thereof
US7534648B2 (en) 2006-06-29 2009-05-19 Intel Corporation Aligned nanotube bearing composite material
US8535791B2 (en) 2006-06-30 2013-09-17 The University Of Akron Aligned carbon nanotube-polymer materials, systems and methods
US7927666B2 (en) 2006-06-30 2011-04-19 The University Of Akron Aligned carbon nanotube-polymer materials, systems and methods
US7955644B2 (en) 2006-07-10 2011-06-07 California Institute Of Technology Method for selectively anchoring large numbers of nanoscale structures
US8846143B2 (en) 2006-07-10 2014-09-30 California Institute Of Technology Method for selectively anchoring and exposing large numbers of nanoscale structures
US8389119B2 (en) 2006-07-31 2013-03-05 The Board Of Trustees Of The Leland Stanford Junior University Composite thermal interface material including aligned nanofiber with low melting temperature binder
US7959969B2 (en) 2007-07-10 2011-06-14 California Institute Of Technology Fabrication of anchored carbon nanotube array devices for integrated light collection and energy conversion
CN101343532B (en) 2007-07-13 2011-06-08 清华大学 Method for preparing carbon nano-tube composite heat interfacial material
US8323732B2 (en) 2007-09-18 2012-12-04 Council Of Scientific & Industrial Research Nanocomposite material useful for the preparation superhydrophobic coating and a process for the preparation thereof
WO2009061510A1 (en) 2007-11-09 2009-05-14 Kirt Lander Insole pad for open backed hoof boots
US8927464B2 (en) 2007-11-29 2015-01-06 President And Fellows Of Harvard College Assembly and deposition of materials using a superhydrophobic surface structure
WO2010052692A1 (en) * 2008-11-04 2010-05-14 Janisys Limited A transfer device for transferring a substance between the device and a subject
EP2381972A2 (en) 2009-01-27 2011-11-02 California Institute Of Technology Drug delivery and substance transfer facilitated by nano-enhanced device having aligned carbon nanotubes protruding from device surface
US20110045080A1 (en) 2009-03-24 2011-02-24 William Marsh Rice University Single-Walled Carbon Nanotube/Bioactive Substance Complexes and Methods Related Thereto
WO2010120564A2 (en) 2009-03-31 2010-10-21 The Regents Of The University Of Michigan Shaping nanostructure arrays
US8272124B2 (en) 2009-04-03 2012-09-25 Formfactor, Inc. Anchoring carbon nanotube columns
JP2011204769A (en) 2010-03-24 2011-10-13 Toshiba Corp Semiconductor device, and method of manufacturing the same
US9115424B2 (en) 2010-04-07 2015-08-25 California Institute Of Technology Simple method for producing superhydrophobic carbon nanotube array
US8784373B2 (en) 2010-09-02 2014-07-22 California Institute Of Technology Drug delivery by carbon nanotube arrays
US8976507B2 (en) 2011-03-29 2015-03-10 California Institute Of Technology Method to increase the capacitance of electrochemical carbon nanotube capacitors by conformal deposition of nanoparticles
WO2013090844A1 (en) 2011-12-14 2013-06-20 California Institute Of Technology Sharp tip carbon nanotube microneedle devices and their fabrication

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005334594A (en) * 2004-05-27 2005-12-08 I-Com:Kk Medication patch with carbon nanotube protrusion
US20060093642A1 (en) * 2004-11-03 2006-05-04 Ranade Shrirang V Method of incorporating carbon nanotubes in a medical appliance, a carbon nanotube medical appliance, and a medical appliance coated using carbon nanotube technology
US20070066934A1 (en) * 2005-09-19 2007-03-22 Transport Pharmaceuticals, Inc. Electrokinetic delivery system and methods therefor
US20070207182A1 (en) * 2006-03-06 2007-09-06 Jan Weber Medical devices having electrically aligned elongated particles
CN101101273A (en) * 2007-06-29 2008-01-09 浙江大学 Carbon nano tube modified blood sugar biosensor
CN101126735A (en) * 2007-09-30 2008-02-20 董益阳 Biosensor and its preparation method and detection method using said biosensor
CN101181989A (en) * 2007-11-20 2008-05-21 浙江大学 Acid choline biomimetic polymers coated carbon-nano tube and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LIMING DAI ET AL: "Functionalized surfaces based on polymers and carbon nanotubes for some biomedical and optoelectronic applications", 《NANOTECHNOLOGY》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108969869A (en) * 2018-07-01 2018-12-11 刘征宇 Sacculus of controllable formula of internal flow reduction ischemia reperfusion injury

Also Published As

Publication number Publication date
US9352136B2 (en) 2016-05-31
WO2010087971A2 (en) 2010-08-05
US20130158377A1 (en) 2013-06-20
US20150238742A1 (en) 2015-08-27
US9050444B2 (en) 2015-06-09
JP2012516202A (en) 2012-07-19
US20100196446A1 (en) 2010-08-05
WO2010087971A3 (en) 2010-12-23
JP5620408B2 (en) 2014-11-05
EP2381972A2 (en) 2011-11-02

Similar Documents

Publication Publication Date Title
CN102292114A (en) Drug delivery and substance transfer facilitated by nano-enhanced device having aligned carbon nanotubes protruding from device surface
Cho et al. Soft bioelectronics based on nanomaterials
US20210393934A1 (en) MEDICAL DEVICES FOR DELIVERY OF siRNA
EP3500168B1 (en) System for subcutaneous bioanalyte sensing
Young et al. Neuro‐nano interfaces: utilizing nano‐coatings and nanoparticles to enable next‐generation electrophysiological recording, neural stimulation, and biochemical modulation
CN103501852B (en) The manufacture method of microstructured bodies
Kim et al. Carbon nanomaterials as versatile platforms for theranostic applications
US20120058170A1 (en) Drug delivery by carbon nanotube arrays
Zhang et al. Bioinspired Functional Surfaces for Medical Devices
Park et al. Immobilized nanoneedle-like structures for intracellular delivery, biosensing and cellular surgery
Loh et al. Design and fabrication of customizable microneedles enabled by 3D printing for biomedical applications
Azizi Machekposhti et al. Microneedle fabrication methods and applications
Han et al. Modern microelectronics and microfluidics on microneedles
Arya et al. Smart nanomaterials in biosensing applications
Yin et al. Carbon nanotube wire for use in precision medical devices
Baghel et al. NANOTECHNOLOGY| N| MEDICAL SCIENCE-PRESENT SCENARIO) AND FUTURE PROSPECTS
이영식 Implantable and minimally-invasive drug delivery system using soft bioelectronics for diagnosis and treatment
KR102102502B1 (en) Biosensor
Periasamy et al. Nanosensors: The Future of Efficient Sensing Technologies in Nanomedicine
Purohit et al. Thread of hope: Weaving a comprehensive review on electrospun nanofibers for cancer therapy
JP5696279B2 (en) Long-term sustained-release drug epidural placement system
Bellucci et al. Biomedical applications of carbon nanotubes and the related cellular toxicity
Justin Chitosan-graphene nanocomposite microneedle arrays for transdermal drug delivery
Dragoman et al. Nanomedicine

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20111221