CN102276932B - Pull-tab outer cover material used for infusion bottles or bags and preparation method thereof - Google Patents
Pull-tab outer cover material used for infusion bottles or bags and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a pull-tab outer cover material used for infusion bottles or bags, and the material provided by the invention comprises the following components in parts by weight: 71-89 parts of polypropylene, 1-9 parts of flexibilizer, 9-25 parts of lubrication resin and 0.01-0.4 part of radiation-resistant accessory ingredient. The melting index of the pull-tab outer cover material used for infusion bottles or bags is 9-60g/min under the condition of 230DEG C and 2160g, and the outer cover material can be directly injected to prepare the pull-tab outer cover material used for infusion bottles or bags. A cover body and the infusion bottles or bags have high welding strength, a pull tab is easy to open, an opening edge is tidy, and the opening force is less than or equal to 60N; the pull tab has small possibility of being ruptured, and the fracture rate of the pull tab is less than or equal to 1%; no low-molecule ingredients are separated out, the size stability is good, and the size change rate of the outer cover is less than or equal to 0.5% before and after disinfection; and the radiation-resistant performance is good, the yellow index is less than or equal to 7 after the material is radiated by 60Co-gamma ray of 25kGy dose, and the material haze is less than or equal to 20.
Description
Technical field
The present invention relates to infusion bottle or bag use material, be specifically related to a kind of infusion bottle or bag usefulness modified polypropene draw-ring type outer cover material and preparation method thereof, belong to medical macromolecular materials technological method field.
Background technology
In recent years, the development of China's infusion solutions plastics packaging industry rapidly.From 2007 to 2009, medical large transfusion plastic packet product share of market brings up to 56% from 34%, plastic wrapping just rises year by year with annual share of market more than 10%, substitutes traditional glass bottle packaging, becomes China's System of Infusion Drugs packaging market Main Trends of The Development.
The plastics infusion solutions comprises two kinds of infusion bottle and transfusion flexible bags, and infusion bottle is made of bottle, exterior and interior cover and rubber cushion, and transfusion flexible bag is made of bag, exterior and interior cover, rubber cushion and linker.The inventor to infusion bottle or bag with on the basis of inner cap research (application number 201010117138.1), further infusion bottle or bag are studied with the draw-ring type enclosing cover, the following problem that exists with the draw-ring type enclosing cover to solve infusion bottle or bag: (1) draw ring opening force is large, be not easy to pull open, the unlatching posterior border is irregular; (2) draw ring toughness is not enough, and draw ring is broken easily; (3) have low molecular composition to separate out, cause the enclosing cover poor dimensional stability, obvious through high-temperature sterilization sterilization after strain, (4) enclosing cover is radiation hardness not, and behind radiation sterilization, xanthochromia is obvious.
Application number is that 200410024446.4 Chinese invention patent discloses a kind of employing acrylic resin (PP) and adds polyethylene (PE), polyolefin elastomer (POE) and KN resin for the infusion bottle cap material, to improve bottle cap and polypropylene bottle welding property is bad, draw ring connects easy to crack, stubborn problem.The dimensional stability of not mentioned product and radiation hardness xanthochromia performance, the prescription that the present invention adopts further promotes draw-ring type enclosing cover material over-all properties, the problems such as infusion bottle or bag are large with draw-ring type enclosing cover draw ring opening force, the unlatching edge is irregular, toughness is not enough have been solved, especially low molecular composition is separated out, product size poor stability and the not good problem of radiation hardness xanthochromia performance.This draw-ring type outer cover material is used for the preparation with infusion bottle or bag draw-ring type enclosing cover that is connected.
Summary of the invention
For existing infusion bottle or bag deficiency with the existence of draw-ring type enclosing cover product, primary and foremost purpose of the present invention is to provide a kind of prescription reasonable, the infusion bottle of good combination property or bag draw-ring type outer cover material; The enclosing cover made from the draw-ring type outer cover material by described infusion bottle or bag has with infusion bottle or bag good weldability, a draw ring easily opens, opens neat in edge, has good toughness simultaneously, draw ring is easy fracture not, separate out without low molecular composition, good stability of the dimension under high-temperature sterilization is difficult for the characteristic of xanthochromia after radiation.
Another object of the present invention is to provide a kind of above-mentioned infusion bottle or the bag preparation method of draw-ring type outer cover material.
Another purpose of the present invention is to provide a kind of infusion bottle or bag draw-ring type enclosing cover that is prepared from by above-mentioned materials.
A further object of the present invention is to provide above-mentioned infusion bottle or the bag preparation method of draw-ring type enclosing cover.
Purpose of the present invention is achieved through the following technical solutions: a kind of infusion bottle or bag are used the draw-ring type outer cover material, comprise following component according to the mass fraction in per 100 mass parts:
Described polypropylene is medical grade polypropylene, contains the ethene of quality percentage composition 2～10%, and its melting index (MI) under 230 ℃ and 2160g condition is 4～35g/10min.
The density of described toughner is 0.86～0.92g/cm
3, melting index is 1～30g/10min under 230 ℃ and 2160g condition.
Described toughner is styrene-butadiene-styrene, styrene-ethylene-butylene-styrene multipolymer (SEBS), styrene-isoprene-styrene copolymer-(SIS), styrene-isoprene-phenylethene hydrogenation multipolymer (SEPS), ethylene propylene copolymer (EPM), ethylene-butylene copolymer, ethene-1-hexene copolymer, POE, the propylene butene multipolymer, at least a in propylene octene copolymer and the ethylene-propylene-diene terpolymers.
Described lubricating resin is one or both in silicone master batch and the nano level polytetrafluoroethylene granule.
Described silicone master batch is that the silicone powder of quality percentage composition 10% and the polyolefin blend of quality percentage composition 90% form, and described nano level polytetrafluoroethylene granule particle size range is 50～800nm.
Described polyolefine preferably under 230 ℃ and 2160g condition melting index be the polypropylene of 10～40g/10min; Preferred 200～the 600nm of described nano level polytetrafluoroethylene granule particle size range.
Described radiation hardness auxiliary agent is the Rosmarinus officinalis compounds with hindered phenol compound to mix the compound that form at 70～90: 10～30 in mass ratio; Or Rosmarinus officinalis compounds and hindered amine compound to mix the compound that form in mass ratio at 70～90: 10～30.
The preferred 7-methoxyl group of described Rosmarinus officinalis compounds rosmanol.
Preferred four [methyl-the β-(3 of described hindered phenol compound, the 5-di-tert-butyl-hydroxy phenyl) propionic ester] pentaerythritol ester (antioxidant 1010), β-(3, the 5-di-tert-butyl-hydroxy phenyl) the positive octadecanol ester of propionic acid (antioxidant 1076), 3,9-two [1,1-dimethyl-2-[(3-tertiary butyl-4-hydroxy-5-aminomethyl phenyl) propionyloxy] ethyl]-2,4,8,10-four oxaspiros [5.5] undecane and 2-[1-(2-hydroxyl-3,5-two tertiary amyl phenyl) ethylene]-4, at least a in the 6-two tertiary amyl phenyl acrylate.
Described hindered amine compound is poly--{ [6-[(1,1,3, the 3-tetramethyl butyl)-imino-]-1,3,5-triazines-2,4-two bases] [2-(2,2,6, the 6-tetramethyl-piperidyl)-amino]-hexylidene-[4-(2,2,6, the 6-tetramethyl-piperidyl)-imino-] (photostabilizer 944), 1,3,5-triazines-2,4,6-triamine, N; N " '-[1, [[4,6-pair-[butyl (1 in 2-ethane-two base-two, 2,2,6,6-pentamethyl--4-piperidyl)-and 1,3,5-triazines-two base] imido grpup]-3, the 1-propylidyne] two [N, N "-two (1,2; 2; 6,6-pentamethyl--4-piperidyl)] (photostabilizer 119); photostabilizer 2020; two (2,2; 6,6-tetramethyl--4-piperidyl) sebate (photostabilizer 770), poly-[(6-morpholinyl-1,3,5-triazines-2, the 4-yl)-((2,2,6,6-tetramethyl--4-piperidyl) imido) hexane-((2,2,6,6-tetramethyl--4-piperidyl) imido)] (photostabilizer 3346) and N, N '-two formyls-N, N '-two (2,2,6,6-tetramethyl--4-piperidines)-at least a in the hexamethylene-diamine (photostabilizer 4050H).
Described hindered amine compound is poly--{ [6-[(1,1,3 preferably, the 3-tetramethyl butyl)-imino-]-1,3,5-triazines-2,4-two bases] [2-(2,2,6, the 6-tetramethyl-piperidyl)-amino]-hexylidene-[4-(2,2,6, the 6-tetramethyl-piperidyl)-imino-] (photostabilizer 944), 1,3,5-triazines-2,4,6-triamine, N; N " '-[1, [[4,6-pair-[butyl (1 in 2-ethane-two base-two, 2,2,6,6-pentamethyl--4-piperidyl)-and 1,3,5-triazines-two base] imido grpup]-3, the 1-propylidyne] two [N; N "-two (1,2,2,6,6-pentamethyl--4-piperidyl)] at least a in (photostabilizer 119) and the photostabilizer 2020.
Above-mentioned infusion bottle or the bag preparation method of draw-ring type outer cover material, comprise following operation steps: first 71～89 parts of polypropylene and 0.01～0.4 part of radiation hardness auxiliary agent are mixed, then add successively 1～9 part of toughner and 9～25 parts of lubricating resins, add in the forcing machine with 50～100rpm speed after mixing, under 150～230 ℃ of temperature, extrude with 300～600rpm speed, water-cooled, drying, pelletizing obtains infusion bottle or bag draw-ring type outer cover material.
Above-mentioned infusion bottle or bag can be applicable to the medical packaging Material Field with the draw-ring type outer cover material.
A kind of infusion bottle or bag draw-ring type enclosing cover that is prepared from by above-mentioned materials.Its preparation method comprises following operation steps: adopt injection moulding machine to be injection molded into the draw-ring type enclosing cover with the draw-ring type outer cover material infusion bottle or bag, injection temperature is 150～230 ℃.
This enclosing cover and common inner cap, rubber cushion be capable of being combined to become infusion bottle or bag draw-ring type combination cover.
The present invention is take polypropylene for medical article as material of main part, and the polypropylene of high-content has guaranteed infusion bottle or the bag close melt temperature of draw-ring type enclosing cover and polypropylene transfusion bottle or infusion bag, guarantees welding strength.
The toughner that the present invention adopts is the multipolymer of ethene, propylene, divinyl and vinylbenzene etc., can improve the consistency of toughner and polypropylene bodies material, and less toughner consumption can obtain good toughening effect, improves polypropylene material fragility.
The lubricating resin that the present invention adopts can play lubrication between molecular chain, and it is more neat that molecular chain is arranged along the material flow path direction, thereby improve draw ring intensity, and draw ring is difficult for breaking; Material stream vertical direction molecular chain orientation degree is low simultaneously, and draw ring is opened easily, opens neat in edge.Lubricating resin also can effectively improve processing fluidity, is convenient to injection moulding.The dimensional stability of enclosing cover is relevant with separating out of additive, and lubricating resin and the matrix phase capacitive of the high molecular that the present invention adopts are good, are difficult for separating out, and have guaranteed the dimensional stability of enclosing cover in high temperature, the autoclave process.Use silicone master batch as lubricant, compare with traditional lower molecular weight auxiliary agent (such as silicone oil), solid-state silicone master batch can not reduce the mechanical property of product, easily disperses, do not move, and the product surface non-greasy, easy to use, be difficult for contaminated.Compare with the micron order tetrafluoroethylene, the benefit of nano level tetrafluoroethylene is the transmittance that does not affect product, and namely transparent, the particle diameter of polytetrafluoroethylparticle particle is less, and is more weak to refraction and the reflection of incident beam, thereby can not cause the product transparency to descend.
The present invention adopts a small amount of Rosmarinus officinalis compounds and hindered phenol compound or hindered amine compound compound as the radiation hardness auxiliary agent, improves chemical stability and the radiation hardness xanthochromia performance of material.
This infusion bottle or bag are high with draw-ring type enclosing cover and bottle/bag welding strength, and draw ring is easily opened, and the unlatching posterior border is neat; Draw ring good toughness, draw ring are difficult for breaking; The unlubricated resin of enclosing cover is separated out, and good stability of the dimension is little through the high-temperature sterilization dimensional change; The enclosing cover radiation hardness, behind radiation sterilization, anti-xanthochromia is effective.
The enclosing cover that the present invention makes is at 121 ℃, and before and after 30min sterilized, draw ring was all easily opened, opening force≤60N, and the opening force variation is not more than 10% before and after the sterilization, and draw ring is easy fracture not, and draw ring fracture rate≤1% is opened neat in edge, without burr.
Before and after the enclosing cover sterilization that the present invention makes, enclosing cover size changing rate≤0.5%.
The outer cover material of the present invention's preparation is at 25kGy dosage
60Yellowness index behind the Co-gamma Rays≤7.
The outer cover material mist degree of the present invention's preparation is less than 20.
Infusion bottle of the present invention or bag by adding an amount of toughner, improve the fragility of material with the draw-ring type outer cover material, make the toughness of enclosing cover material and rigidity reach balance; By adding lubricating resin, increase regular arrangement between the molecular chain on the material flow path direction, when improving draw ring self intensity, improve the unlatching performance of enclosing cover, and effectively improve processing fluidity, be convenient to injection moulding; The consistency that the lubricating resin of high molecular and body material are good has guaranteed that lubricating resin is difficult for separating out, and has guaranteed the dimensional stability of material.Above method neither can rupture and pull open easily the enclosing cover draw ring, and has kept preferably the dimensional stability of material.Add Rosmarinus officinalis compounds and hindered phenol/aminated compounds as the radiation hardness auxiliary agent, can catch the free radical by heat or radiation generation, effectively avoid the Yellowing that occurs in the thermal-oxidative degradation of material and the sterilizing process.
The present invention has following advantage and effect:
(1) the present invention carries out toughening modifying take polypropylene material as base mateiral to polypropylene, the infusion bottle that obtains or the bag with the draw-ring type outer cover material 230 ℃ with the 2160g condition under melting index (MI) be 9～60g/10min.Outer cover material becomes infusion bottle or bag uses combination cover through the enclosing cover of injection-moulding device preparation and common inner cap, rubber cushion are capable of being combined.Combination cover and plastic infusion bottle/bag welding strength is high, and draw ring is easily opened, and opens neat in edge; The draw ring good toughness, draw ring is easy fracture not; Enclosing cover is separated out without low molecule lubricating resin, and good stability of the dimension is little through the high-temperature sterilization dimensional change; The enclosing cover radiation hardness, behind radiation sterilization, anti-xanthochromia is effective.
(2) the enclosing cover draw ring made of the present invention is easily opened, and draw ring is easy fracture not.Enclosing cover is at 121 ℃, and before and after 30min sterilized, draw ring was all easily opened, opening force≤60N, and the opening force variation is not more than 10% before and after the sterilization, and draw ring is easy fracture not, and draw ring fracture rate≤1% is opened neat in edge, without burr.
(3) the enclosing cover good stability of the dimension made of the present invention, before and after the sterilization, enclosing cover size changing rate≤0.5%.
(4) the outer cover material radiation resistance of the present invention's preparation is good, at 25kGy dosage
60Yellowness index behind the Co-gamma Rays≤7.
(5) the outer cover material transparency of the present invention's preparation is good, and mist degree is less than 20.
Embodiment
The present invention is described in further detail below in conjunction with embodiment, but embodiments of the present invention are not limited to this.
Embodiment 1
(ethylene content is quality percentage composition 9% with polypropylene, MI is 5g/10min under 230 ℃ and 2160g condition) 71 mass parts and radiation hardness auxiliary agent (7-methoxyl group rosmanol and four [methyl-β-(3, the 5-di-tert-butyl-hydroxy phenyl) propionic ester] pentaerythritol ester mix to form in mass ratio at 70: 30) 0.05 mass parts mixes, (density is 0.88g/cm then to add successively styrene-butadiene-styrene
3MI is 6g/10min under 230 ℃ and 2160g condition) 9 mass parts and lubricating resin (with 12.95 mass parts tetrafluoroethylene (particle diameter 400nm) mixed get by 7 mass parts silicone master batch (with the silicone powder of quality percentage composition 10% and quality percentage composition 90% polypropene blended)) 19.95 mass parts, after mixing, then the speed with 60rpm adds in the forcing machine under 150 ℃, speed with 300rpm is extruded, water-cooled, granulation, drying makes infusion bottle or bag draw-ring type outer cover material.Prepared infusion bottle or bag are with the test under 230 ℃ and 2160g condition of the molten finger of draw-ring type outer cover material (detect according to GB/T 3682-2000, following examples with).The enclosing cover opening force that uses prepared infusion bottle or bag to make with the draw-ring type outer cover material is tested according to YBB00242004, the draw ring fracture rate is tested according to YBB00242004, size changing rate is tested according to YBB00242004 before and after the enclosing cover sterilization, the yellowness index of outer cover material after the radiation of 25kGy dosage detects according to GB/T 2409-1980, and the mist degree of outer cover material is according to GB/T 2410-2008 test (following examples together); Above the performance test results is as shown in table 1.
Embodiment 2
(ethylene content is quality percentage composition 4% with polypropylene, MI is 30g/10min under 230 ℃ and 2160g condition) (7-methoxyl group rosmanol and β-(3 for 75 mass parts and radiation hardness auxiliary agent, the 5-di-tert-butyl-hydroxy phenyl) the positive octadecanol ester of propionic acid mix to form in mass ratio at 90: 10) 0.2 mass parts mixes, and (density is 0.86g/cm then to add successively the quality percentage composition and respectively be 50% styrene-butadiene-styrene
3, MI is 5g/10min under 230 ℃ and 2160g condition) and (density is 0.89g/cm with ethylene-butylene copolymer
3MI is 18g/10min under 230 ℃ and 2160g condition) totally 8 mass parts, and lubricating resin (mixed with 10.8 mass parts tetrafluoroethylene (particle diameter 500nm) by 6 mass parts silicone master batch (with the silicone powder of quality percentage composition 10% and quality percentage composition 90% polypropene blended) and get) 16.8 mass parts, after mixing, then the speed with 60rpm adds in the forcing machine under 180 ℃, speed with 400rpm is extruded, water-cooled, granulation, dry, make infusion bottle or the bag use the draw-ring type outer cover material, the performance test results is as shown in table 1.
Embodiment 3
(ethylene content is quality percentage composition 8% with polypropylene, MI is 8g/10min under 230 ℃ and 2160g condition) 80 mass parts and radiation hardness auxiliary agent (7-methoxyl group rosmanol and 3,9-two [1,1-dimethyl-2-[(3-tertiary butyl-4-hydroxy-5-aminomethyl phenyl) propionyloxy] ethyl]-2,4,8,10-four oxaspiros [5.5] undecane mix to form in mass ratio at 80: 20) 0.3 mass parts mixes, and (density is 0.89g/cm then to add successively the quality percentage composition and respectively be 50% styrene-butadiene-styrene
3, MI is 8g/10min under 230 ℃ and 2160g condition) and (density is 0.87g/cm with the styrene-ethylene-butylene-styrene multipolymer
3MI is 20g/10min under 230 ℃ and 2160g condition) totally 6 mass parts, and lubricating resin (mixed with 9.7 mass parts tetrafluoroethylene (particle diameter 600nm) by 4 mass parts silicone master batch (with the silicone powder of quality percentage composition 10% and quality percentage composition 90% polypropene blended) and get) 13.7 mass parts, after mixing, then the speed with 80rpm adds in the forcing machine under 210 ℃, speed with 500rpm is extruded, water-cooled, granulation, dry, make infusion bottle or the bag use the draw-ring type outer cover material, the performance test results is as shown in table 1.
Embodiment 4
(ethylene content is quality percentage composition 6% with polypropylene, MI is 15g/10min under 230 ℃ and 2160g condition) 85 mass parts and radiation hardness auxiliary agent (7-methoxyl group rosmanol and 2-[1-(2-hydroxyl-3,5-two tertiary amyl phenyl) ethylene]-4,6-two tertiary amyl phenyl acrylate mix to form in mass ratio at 75: 25) 0.1 mass parts mixes, and (density is 0.85g/cm then to add successively the quality percentage composition and respectively be 50% styrene-ethylene-butylene-styrene multipolymer
3, MI is 10g/10min under 230 ℃ and 2160g condition) and (density is 0.91g/cm with propylene ethylene copolymers
3MI is 25g/10min under 230 ℃ and 2160g condition) totally 4 mass parts, and lubricating resin (mixed with 5.9 parts of tetrafluoroethylene (particle diameter 200nm) by 5 mass parts silicone master batch (with the silicone powder of quality percentage composition 10% and quality percentage composition 90% polypropene blended) and get) 10.9 mass parts, after mixing, then the speed with 100rpm adds in the forcing machine under 230 ℃, speed with 600rpm is extruded, water-cooled, granulation, dry, make infusion bottle or the bag use the draw-ring type outer cover material, the performance test results is as shown in table 1.
Embodiment 5
(ethylene content is quality percentage composition 3% with polypropylene, MI is 20g/10min under 230 ℃ and 2160g condition) 89 mass parts and radiation hardness auxiliary agent (7-methoxyl group rosmanol and 2-[1-(2-hydroxyl-3,5-two tertiary amyl phenyl) ethylene]-4,6-two tertiary amyl phenyl acrylate mix to form in mass ratio at 85: 15) 0.02 mass parts mixes, and (density is 0.89g/cm then to add successively the quality percentage composition and respectively be 50% styrene-isoprene-styrene copolymer-
3, MI is 2g/10min under 230 ℃ and 2160g condition) and (density is 0.90g/cm with POE
3MI is 20g/10min under 230 ℃ and 2160g condition) totally 5 mass parts, and lubricating resin (mixed with 9.98 mass parts tetrafluoroethylene (particle diameter 500nm) by 6 mass parts silicone master batch (with the silicone powder of quality percentage composition 10% and quality percentage composition 90% polypropene blended) and get) 15.98 mass parts, after mixing, then the speed with 90rpm adds in the forcing machine under 170 ℃, speed with 350rpm is extruded, water-cooled, granulation, dry, make infusion bottle or the bag use the draw-ring type outer cover material, the performance test results is as shown in table 1.
Embodiment 6
(ethylene content is quality percentage composition 6% with polypropylene, MI is 15g/10min under 230 ℃ and 2160g condition) 85 mass parts and radiation hardness auxiliary agent (7-methoxyl group rosmanol and gathering-{ [6-[(1,1,3, the 3-tetramethyl butyl)-and imino-]-1,3,5-triazine-2,4-two bases] [2-(2,2,6, the 6-tetramethyl-piperidyl)-amino]-hexylidene-[4-(2,2,6, the 6-tetramethyl-piperidyl)-imino-] mix to form at 80: 20 in mass ratio) 0.1 mass parts mixes, (density is 0.85g/cm then to add successively the quality percentage composition and respectively be 50% styrene-ethylene-butylene-styrene multipolymer
3, MI is 10g/10min under 230 ℃ and 2160g condition) and (density is 0.91g/cm with propylene ethylene copolymers
3MI is 25g/10min under 230 ℃ and 2160g condition) totally 4 mass parts, and lubricating resin (mixed with 5.9 parts of tetrafluoroethylene (particle diameter 200nm) by 5 mass parts silicone master batch (with the silicone powder of quality percentage composition 10% and quality percentage composition 90% polypropene blended) and get) 10.9 mass parts, after mixing, then the speed with 100rpm adds in the forcing machine under 230 ℃, speed with 600rpm is extruded, water-cooled, granulation, dry, make infusion bottle or the bag use the draw-ring type outer cover material, the performance test results is as shown in table 1.
Embodiment 7
(ethylene content is quality percentage composition 3% with polypropylene, MI is 20g/10min under 230 ℃ and 2160g condition) 89 mass parts and radiation hardness auxiliary agent (7-methoxyl group rosmanol and 1,3,5-triazine-2,4, the 6-triamine, N, N " '-[two [N; N of 1,2-ethane-two base-two [[4; 6-pair-[butyl (1; 2,2,6; 6-pentamethyl--4-piperidyl)-1; 3,5-triazine-two base] imido grpup]-3,1-propylidyne] "-two (1,2,2,6,6-pentamethyl--4-piperidyl)] mix forming at 85: 15 in mass ratio) 0.02 mass parts mixes, and (density is 0.89g/cm then to add successively the quality percentage composition and respectively be 50% styrene-isoprene-styrene copolymer-
3, MI is 2g/10min under 230 ℃ and 2160g condition) and (density is 0.90g/cm with POE
3MI is 20g/10min under 230 ℃ and 2160g condition) totally 5 mass parts, and lubricating resin (mixed with 9.98 mass parts tetrafluoroethylene (particle diameter 500nm) by 6 mass parts silicone master batch (with the silicone powder of quality percentage composition 10% and quality percentage composition 90% polypropene blended) and get) 15.98 mass parts, after mixing, then the speed with 90rpm adds in the forcing machine under 170 ℃, speed with 350rpm is extruded, water-cooled, granulation, dry, make infusion bottle or the bag use the draw-ring type outer cover material, the performance test results is as shown in table 1.
The comparative example 1
(ethylene content is quality percentage composition 9% with polypropylene, MI is 5g/10min under 230 ℃ and 2160g condition) 71 mass parts and radiation hardness auxiliary agent (7-methoxyl group rosmanol and four [methyl-β-(3, the 5-di-tert-butyl-hydroxy phenyl) propionic ester] pentaerythritol ester mix to form in mass ratio at 70: 30) 0.05 mass parts mixes, (density is 0.88g/cm then to add successively styrene-butadiene-styrene
3MI is 6g/10min under 230 ℃ and 2160g condition) 9 mass parts and 7 mass parts mineral drugs oil (viscosity is 68mPa.s) and 12.95 mass parts tetrafluoroethylene (particle diameter 400nm), after mixing, then the speed with 60rpm adds in the forcing machine under 150 ℃, speed with 300rpm is extruded, water-cooled, granulation, drying makes infusion bottle or bag draw-ring type outer cover material.Prepared infusion bottle or bag are 52g/10min with draw-ring type outer cover material MI under 230 ℃ and 2160g condition) (detect according to GB/T 3682-2000, following examples are same), the performance test results is as shown in table 1.
The comparative example 2
(ethylene content is quality percentage composition 4% with polypropylene, MI is 30g/10min under 230 ℃ and 2160g condition) (7-methoxyl group rosmanol and β-(3 for 75 mass parts and radiation hardness auxiliary agent, the 5-di-tert-butyl-hydroxy phenyl) the positive octadecanol ester of propionic acid mix to form in mass ratio at 90: 10) 0.2 mass parts mixes, and (density is 0.86g/cm then to add successively the quality percentage composition and respectively be 50% styrene-butadiene-styrene
3, MI is 5g/10min under 230 ℃ and 2160g condition) and (density is 0.89g/cm with ethylene-butylene copolymer
3MI is 18g/10min under 230 ℃ and 2160g condition) totally 8 mass parts, after mixing with 16.8 mass parts mineral drugs oil (viscosity 100mPa.s), then the speed with 60rpm adds in the forcing machine under 180 ℃, extrudes water-cooled with the speed of 400rpm, granulation, drying makes infusion bottle or bag is used the draw-ring type outer cover material, and the performance test results is as shown in table 1.
The comparative example 3
(ethylene content is quality percentage composition 8% with polypropylene, MI is 8g/10min under 230 ℃ and 2160g condition) 80 mass parts and radiation hardness auxiliary agent (7-methoxyl group rosmanol and 3,9-two [1,1-dimethyl-2-[(3-tertiary butyl-4-hydroxy-5-aminomethyl phenyl) propionyloxy] ethyl]-2,4,8,10-four oxaspiros [5.5] undecane mix to form in mass ratio at 80: 20) 0.3 mass parts mixes, and (density is 0.89g/cm then to add successively the quality percentage composition and respectively be 50% styrene-butadiene-styrene
3, MI is 8g/10min under 230 ℃ and 2160g condition) and (density is 0.87g/cm with the styrene-ethylene-butylene-styrene multipolymer
3MI is 20g/10min under 230 ℃ and 2160g condition) totally 6 mass parts, and lubricating resin (by 4 mass parts polyethylene waxs (molecular weight 2500-3000) and 9.7 mass parts tetrafluoroethylene (particle diameter 600nm), 13.7 mass parts, after mixing, then the speed with 80rpm adds in the forcing machine under 210 ℃, speed with 500rpm is extruded, water-cooled, granulation, drying, make infusion bottle or the bag use the draw-ring type outer cover material, the performance test results is as shown in table 1.
The comparative example 4
(ethylene content is quality percentage composition 6% with polypropylene, MI is 15g/10min under 230 ℃ and 2160g condition) 85 mass parts and radiation hardness auxiliary agent (7-methoxyl group rosmanol and 2-[1-(2-hydroxyl-3,5-two tertiary amyl phenyl) ethylene]-4,6-two tertiary amyl phenyl acrylate mix to form in mass ratio at 75: 25) 0.1 mass parts mixes, and (density is 0.85g/cm then to add successively the quality percentage composition and respectively be 50% styrene-ethylene-butylene-styrene multipolymer
3, MI is 10g/10min under 230 ℃ and 2160g condition) and (density is 0.91g/cm with propylene ethylene copolymers
3MI is 25g/10min under 230 ℃ and 2160g condition) totally 4 mass parts, mix with 5.9 parts of tetrafluoroethylene (particle diameter 200nm) with 5 mass parts Poly Propylene Waxes (molecular weight 4500) and get) 10.9 mass parts, after mixing, then the speed with 100rpm adds in the forcing machine under 230 ℃, speed with 600rpm is extruded, water-cooled, granulation, drying, make infusion bottle or the bag use the draw-ring type outer cover material, the performance test results is as shown in table 1.
The comparative example 5
(ethylene content is quality percentage composition 3% with polypropylene, MI is 20g/10min under 230 ℃ and 2160g condition) 88 mass parts and primary antioxidant (7-methoxyl group rosmanol and 2-[1-(2-hydroxyl-3,5-two tertiary amyl phenyl) ethylene]-4,6-two tertiary amyl phenyl acrylate mix to form in mass ratio at 85: 15) 0.02 mass parts mixes, and (density is 0.89g/cm then to add successively the quality percentage composition and respectively be 50% styrene-isoprene-styrene copolymer-
3, MI is 2g/10min under 230 ℃ and 2160g condition) and (density is 0.90g/cm with POE
3MI is 20g/10min under 230 ℃ and 2160g condition) totally 10 mass parts, and N, N '-ethylene bis stearamide 1.98 mass parts, after mixing, then the speed with 90rpm adds in the forcing machine under 170 ℃, extrudes water-cooled with the speed of 350rpm, granulation, drying makes infusion bottle or bag is used the draw-ring type outer cover material, and the performance test results is as shown in table 1.
The comparative example 6
(ethylene content is quality percentage composition 6% with polypropylene, MI is 15g/10min under 230 ℃ and 2160g condition) 85 mass parts and processing stabilizers three (2, the 4-di-tert-butyl-phenyl) phosphorous acid ester 0.1 mass parts mixes, and (density is 0.85g/cm then to add successively the quality percentage composition and respectively be 50% styrene-ethylene-butylene-styrene multipolymer
3, MI is 10g/10min under 230 ℃ and 2160g condition) and (density is 0.91g/cm with propylene ethylene copolymers
3MI is 25g/10min under 230 ℃ and 2160g condition) totally 4 mass parts, and lubricating resin are (by 5 mass parts dimethyl silicone oils (viscosity 90,000mPa.s) mix with 5.9 parts of tetrafluoroethylene (particle diameter 3um) and get), 10.9 mass parts, after mixing, then the speed with 100rpm adds in the forcing machine under 230 ℃, extrudes water-cooled with the speed of 600rpm, granulation, drying makes infusion bottle or bag is used the draw-ring type outer cover material, and the performance test results is as shown in table 1.
The comparative example 7
(ethylene content is quality percentage composition 3% with polypropylene, MI is 20g/10min under 230 ℃ and 2160g condition) 89.1 mass parts, (density is 0.89g/cm then to add successively the quality percentage composition and respectively be 50% styrene-isoprene-styrene copolymer-
3, MI is 2g/10min under 230 ℃ and 2160g condition) and (density is 0.90g/cm with POE
3MI is 20g/10min under 230 ℃ and 2160g condition) totally 5 mass parts, and lubricating resin is (by 6 mass parts dimethyl silicone oil (viscosity 130,000mPa.s) mix with 9.98 mass parts tetrafluoroethylene (particle diameter 5um) and get) 15.98 mass parts, after mixing, then the speed with 90rpm adds in the forcing machine under 170 ℃, speed with 350rpm is extruded, water-cooled, granulation, drying makes infusion bottle or bag is used the draw-ring type outer cover material, and the performance test results is as shown in table 1.
Table 1 infusion bottle of the present invention or bag draw-ring type outer cover material the performance test results
Comparative example 1,2,6 and 7 is at basis of the present invention liquid lubrication auxiliary agent as seen from Table 1, be that mineral drug oil or silicone oil replace high molecular weight silicone resin and tetrafluoroethylene, the enclosing cover draw ring fracture rate of resulting materials preparation increases, and size changing rate obviously increases; Comparative example 3,4 and 5 replaces high molecular weight silicone resin and tetrafluoroethylene on basis of the present invention with polyethylene wax and Poly Propylene Wax, and the enclosing cover opening force of resulting materials preparation obviously increases, and the draw ring fracture rate raises; Comparative example 6 and 7 replaces the Compositional type radiation hardness agent of Rosmarinus officinalis compounds and hindered phenol/aminated compounds or does not add the radiation hardness auxiliary agent with the radiation hardness agent of other types on basis of the present invention, and the enclosing cover irradiation sterilization after yellowing index of resulting materials preparation obviously increases; Comparative example 6 and 7 adopts the large tetrafluoroethylene of particle diameter, and the prepared material transparency descends, and mist degree obviously increases.
Above-described embodiment is the better embodiment of the present invention; but embodiments of the present invention are not restricted to the described embodiments; other any do not deviate from change, the modification done under spirit of the present invention and the principle, substitutes, combination, simplify; all should be the substitute mode of equivalence, be included within protection scope of the present invention.
Claims (8)
1. an infusion bottle or bag are used the draw-ring type outer cover material, it is characterized in that comprising following component according to the mass fraction:
71～89 parts of polypropylene
1～9 part of toughner
9～25 parts of lubricating resins
0.01～0.4 part of radiation hardness auxiliary agent;
Described polypropylene contains the ethene of quality percentage composition 2～10%, and its melting index under 230 ℃ and 2160g condition is 4～35g/10min;
The density of described toughner is 0.86～0.92g/cm
3, melting index is 1～30g/10min under 230 ℃ and 2160g condition; Described toughner is at least a in styrene-butadiene-styrene, styrene-ethylene-butylene-styrene multipolymer, styrene-isoprene-styrene copolymer-, styrene-isoprene-phenylethene hydrogenation multipolymer, ethylene propylene copolymer, ethylene-butylene copolymer, ethene-1-hexene copolymer, POE, propylene butene multipolymer, propylene octene copolymer and the ethylene-propylene-diene terpolymers;
To be the Rosmarinus officinalis compounds mix the compound that forms with hindered phenol compound with 70～90:10～30 in mass ratio with described radiation hardness auxiliary agent, or Rosmarinus officinalis compounds and hindered amine compound mix the compound of formation with 70～90:10～30 in mass ratio;
Described lubricating resin is one or both in silicone master batch and the nano level polytetrafluoroethylene granule.
2. infusion bottle according to claim 1 or bag are used the draw-ring type outer cover material, and it is characterized in that: described silicone master batch is that the silicone powder of quality percentage composition 10% and the polyolefin blend of quality percentage composition 90% form; Described nano level polytetrafluoroethylene granule particle size range is 50～800nm.
Infusion bottle according to claim 2 or the bag use the draw-ring type outer cover material, it is characterized in that: described polyolefine for 230 ℃ with the 2160g condition under melting index be the polypropylene of 10～40g/10min; Described nano level polytetrafluoroethylene granule particle size range is 200～600nm.
4. infusion bottle according to claim 1 or bag are used the draw-ring type outer cover material, and it is characterized in that: described Rosmarinus officinalis compounds is 7-methoxyl group rosmanol; Described hindered phenol compound is four [methyl-β-(3, the 5-di-tert-butyl-hydroxy phenyl) propionic ester] pentaerythritol ester, β-(3, the 5-di-tert-butyl-hydroxy phenyl) the positive octadecanol ester of propionic acid, 3,9-two [1,1-dimethyl-2-[(3-tertiary butyl-4-hydroxy-5-aminomethyl phenyl) propionyloxy] ethyl]-2,4,8,10-four oxaspiros [5.5] undecane and 2-[1-(2-hydroxyl-3,5-two tertiary amyl phenyl) ethylene]-4, at least a in the 6-two tertiary amyl phenyl acrylate; Described hindered amine compound is poly--{ [6-[(1,1,3,3-tetramethyl butyl)-imino-]-1,3,5-triazine-2,4-two bases] [2-(2,2,6,6-tetramethyl-piperidyl)-amino]-hexylidene-[4-(2,2,6, the 6-tetramethyl-piperidyl)-imino-], 1,3,5-triazines-2,4,6-triamine, N; N " '-[1, [[4,6-pair-[butyl (1 in 2-ethane-two base-two, 2,2,6,6-pentamethyl--4-piperidyl)-and 1,3,5-triazines-two base] imido grpup]-3, the 1-propylidyne] at least a in two [N, N "-two (1,2; 2,6,6-pentamethyl--4-piperidyl)] and the photostabilizer 2020.
Infusion bottle according to claim 1 or the bag use the draw-ring type outer cover material, it is characterized in that: described infusion bottle or the bag with the draw-ring type outer cover material 230 ℃ with the 2160g condition under melting index be 9～60g/10min.
6. infusion bottle according to claim 1 or bag are with the preparation method of draw-ring type outer cover material, it is characterized in that comprising following operation steps: first 71～89 parts of polypropylene and 0.01～0.4 part of radiation hardness auxiliary agent are mixed, then add successively 1～9 part of toughner and 9～25 parts of lubricating resins, add in the forcing machine with 50～100rpm speed after mixing, under 150～230 ℃ of temperature, extrude with 300～600rpm speed, water-cooled, dry, pelletizing obtains infusion bottle or bag draw-ring type outer cover material;
Described polypropylene contains the ethene of quality percentage composition 2～10%, and its melting index under 230 ℃ and 2160g condition is 4～35g/10min;
The density of described toughner is 0.86～0.92g/cm
3, melting index is 1～30g/10min under 230 ℃ and 2160g condition; Described toughner is at least a in styrene-butadiene-styrene, styrene-ethylene-butylene-styrene multipolymer, styrene-isoprene-styrene copolymer-, styrene-isoprene-phenylethene hydrogenation multipolymer, ethylene propylene copolymer, ethylene-butylene copolymer, ethene-1-hexene copolymer, POE, propylene butene multipolymer, propylene octene copolymer and the ethylene-propylene-diene terpolymers;
To be the Rosmarinus officinalis compounds mix the compound that forms with hindered phenol compound with 70～90:10～30 in mass ratio with described radiation hardness auxiliary agent, or Rosmarinus officinalis compounds and hindered amine compound mix the compound of formation with 70～90:10～30 in mass ratio;
Described lubricating resin is one or both in silicone master batch and the nano level polytetrafluoroethylene granule.
7. an infusion bottle that is prepared from by each described material of claim 1～5 or bag draw-ring type enclosing cover.
8. infusion bottle according to claim 7 or bag are with the preparation method of draw-ring type enclosing cover, and it is characterized in that comprising following operation steps: infusion bottle or bag are injection molded into the draw-ring type enclosing cover with draw-ring type outer cover material employing injection moulding machine, and injection temperature is 150～230 ℃.
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| CN102247288B (en) * | 2011-04-11 | 2014-07-09 | 北京化工大学 | Easily-opened easily-disinfected plastic ampoule bottle |
| CN102585381B (en) * | 2011-12-29 | 2013-10-23 | 广州市合诚化学有限公司 | Material for full-closed infusion polypropylene upright soft bottle and preparation method and application of material |
| CN102604234B (en) * | 2012-02-07 | 2013-11-06 | 安徽双鹤药用包装有限公司 | Dedicated material for outer cover of polypropylene combination cover of transfusion container and production method of dedicated material |
| CN103445962A (en) * | 2013-09-06 | 2013-12-18 | 苏州创扬医药包装科技有限公司 | Polypropylene pull ring type combination cap for plastic infusion containers, and production method thereof |
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| CN104212080B (en) * | 2014-09-24 | 2016-08-24 | 广州市合诚化学有限公司 | For manufacturing infusion bottle or the self lubricity composite of bag Easy-folding enclosing cover |
| CN107033504A (en) * | 2016-12-13 | 2017-08-11 | 德阳力久云智知识产权运营有限公司 | A kind of wear-resistant and crack-resistant modified plastics and preparation method thereof |
| CN106916406A (en) * | 2017-04-20 | 2017-07-04 | 苏州康邦新材料有限公司 | A kind of TPE infusion bags and preparation method thereof |
| CN107383583B (en) * | 2017-09-15 | 2020-10-13 | 广州市合诚化学有限公司 | Outer cover material with high rigidity and low opening force, and preparation method and application thereof |
| CN111187468B (en) * | 2019-12-28 | 2022-06-24 | 会通新材料股份有限公司 | Boiling-resistant color-changing polypropylene composite material and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101367965A (en) * | 2008-10-09 | 2009-02-18 | 中国科学院广州化学研究所 | Uses of rosmarinus officinalis extract as anti-oxidant in superpolymer |
| CN101696302A (en) * | 2009-10-29 | 2010-04-21 | 广州市合诚化学有限公司 | Self-lubricating polypropylene compound material for manufacturing medical injectors |
| CN101792558A (en) * | 2010-02-23 | 2010-08-04 | 广州市合诚化学有限公司 | Inner cap material for transfusion packages, and preparation method and applications thereof |
| CN101967247A (en) * | 2010-11-03 | 2011-02-09 | 苏州晋圣博高分子材料科技有限公司 | Medicinal low-temperature-resistant toughening anti-gamma ray impact-resistant transparent polypropylene material and preparation method thereof |
-
2011
- 2011-08-03 CN CN 201110220700 patent/CN102276932B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101367965A (en) * | 2008-10-09 | 2009-02-18 | 中国科学院广州化学研究所 | Uses of rosmarinus officinalis extract as anti-oxidant in superpolymer |
| CN101696302A (en) * | 2009-10-29 | 2010-04-21 | 广州市合诚化学有限公司 | Self-lubricating polypropylene compound material for manufacturing medical injectors |
| CN101792558A (en) * | 2010-02-23 | 2010-08-04 | 广州市合诚化学有限公司 | Inner cap material for transfusion packages, and preparation method and applications thereof |
| CN101967247A (en) * | 2010-11-03 | 2011-02-09 | 苏州晋圣博高分子材料科技有限公司 | Medicinal low-temperature-resistant toughening anti-gamma ray impact-resistant transparent polypropylene material and preparation method thereof |
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