CN102266314A - Sterilization agent special for livestock and preparation method and application thereof - Google Patents
Sterilization agent special for livestock and preparation method and application thereof Download PDFInfo
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- CN102266314A CN102266314A CN2011101475894A CN201110147589A CN102266314A CN 102266314 A CN102266314 A CN 102266314A CN 2011101475894 A CN2011101475894 A CN 2011101475894A CN 201110147589 A CN201110147589 A CN 201110147589A CN 102266314 A CN102266314 A CN 102266314A
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Abstract
The invention relates to a sterilization agent special for livestock and a preparation method and application thereof. The preparation method comprises the following steps of: adding 0.01-5 parts of chlorhexidine acetate, 0.002-10 parts of p-octyl polyethylene glycol phenyl ether and 63-99.958 parts of tap water into a container; mixing and stirring uniformly; heating to 65-70 DEG C; adding 0.02-12 parts of benzalkonium chloride; stirring and heating to 92-94 DEG C; cooling to 18-26 DEG C; adding 0.01-10 parts of glutaraldehyde and stirring uniformly; and adjusting the pH value to 6-10 with sodium hydroxide or sodium bicarbonate to obtain the sterilization agent. The sterilization agent is special for sterilizing and disinfecting livestock furs, oral cavities, endometrium, vaginas, vulvas, breasts, houses, air and object surfaces, and treating fur and mucous membrane diseases. Compared with the traditional sterilizing and disinfecting liquid, the sterilization agent has the characteristics of large number of sterilizing types, high sterilizing rate, simple preparation process, low cost, definite curative effect on livestock and using safety and reliability.
Description
Technical field
The present invention relates to a kind of poultry special sterilizing medicament and manufacture method and purposes.
Background technology
At present, constantly composite to the chemical sterilization material, increase new application and scope, with reach potentiation, multipurpose is the problem that modern antibacterial will solve.Chinese invention patent number: 200510090828.1, a kind of Manufacturing approach and use of disinfection sanitizer is disclosed, this invention by: chlorhexidine acetate, benzalkonium bromide, sulphur ammonium acetyl ammonium, OP emulsifying agent and water are formed.This invention sterilization kind is few, sterilizing rate is lower, can not kill poultry H
5N1 subtype avian influenza virus, vaccinia virus, new metropolitan area virus, Hemolytic streptococcus, Salmonella typhimurium, Pullorum Disease Salmonella, Salmonella anatis, Salmonella choleraesuls, cattle kind cloth Salmonella S19, pig kind cloth Salmonella 1130, sheep kind cloth Salmonella B115, clostridium tetani, rabies bacterium, have a liking for skin bacterium, chlamydia, mycoplasma.Because the used water of this invention is pure water or distilled water, manufacturing cost is higher, is not suitable for poultry.Sulphur ammonium acetyl ammonium belongs to topical antibiotic in this invention, easily produces milk and contains anti-being used for cow endometritis treatment.
Application for a patent for invention number: 201010292526.3, a kind of compound recipe aqueous multiple-effect, environmentally-friendly antibacterial and manufacture method and purposes are disclosed, this invention by: chlorhexidine acetate, sulphacetamide, Triton X-100, pure water or distilled water are formed.This invention weak point: to poultry pathogenic bacteria virus to kill kind few, can not kill poultry H
5N1 subtype avian influenza virus, Hemolytic streptococcus, Pullorum Disease Salmonella, Salmonella anatis, Salmonella choleraesuls, cattle kind cloth Salmonella S19, pig kind cloth Salmonella 1130, sheep kind cloth Salmonella B115, clostridium tetani, rabies bacterium, chlamydia, mycoplasma.Because the used water of this invention is pure water or distilled water also, manufacturing cost is higher, is not suitable for poultry.Sulphacetamide belongs to the weak property antibiotic of external preparation for skin in this invention, easily produces milk and contains anti-being used for the cow endometritis treatment.
Summary of the invention
The purpose of this invention is to provide and a kind ofly be exclusively used in poultry sterilizations, and can treat poultry fur, oral cavity, endometrium, interior vulva, and manufacture method is simple, poultry bactericide specially and the manufacture method and the purposes of low cost of manufacture.
The objective of the invention is to be achieved through the following technical solutions:
The present invention is made up of following substances in parts by weight:
0.01～5 part of chlorhexidine acetate, 0.002～10 part of Triton X-100,0.02～12 part of benzalkonium chloride, 0.01～10 part of glutaraldehyde, 63～99.958 parts in tap water.
Manufacture method of the present invention is as follows:
Get 0.01～5 part of chlorhexidine acetate, 0.002～10 part of Triton X-100,63～99.958 parts in tap water, put into container, after the mixing and stirring, be heated to 65～70 ℃, add 0.02～12 part of benzalkonium chloride again, be heated with stirring to 92～94 ℃, and then be cooled to 18～26 ℃, obtain mixed liquor, get again in 0.01～10 part of adding of glutaraldehyde mixed liquor and stir, reuse sodium hydroxide or sodium bicarbonate are adjusted pH value, and making pH value is 6～10, promptly makes.
Purposes of the present invention is as follows:
The present invention is exclusively used in the sterilizing of poultry fur, oral cavity, endometrium, interior pudendum, breast, colony house, air and body surface.
The present invention is by different dilution proportion, can be in 30 seconds～60 minutes 100% kill escherichia coli, staphylococcus aureus, bacillus pyocyaneus, Candida albicans, Staphylococcus albus, gram negative bacteria, gram positive bacteria.
The present invention can 100% kill H
5N1 subtype avian influenza virus, new metropolitan area virus, hemolytic hammer, Salmonella typhimurium, Pullorum Disease Salmonella, Salmonella anatis, Salmonella choleraesuls, cattle kind cloth Salmonella S19, pig kind cloth Salmonella 1130, sheep kind cloth Salmonella B115, clostridium tetani, rabies bacterium, chlamydia, mycoplasma, have a liking for skin bacterium, bacillus subtilis black variety gemma.
The present invention is festered, suppurates, is scratched the domestic animal oral cavity, to the tinea on domestic animal skin, the hoof skin, suppuration, scald, wound, knife injury, pruritus, to the endometritis of domestic animal, vaginitis, all have antiinflammatory, convergence, pain relieving, antipruritic, the therapeutical effect that eliminates the unusual smell, belong to the non-antibiotic medicine.
Toxicology characteristic of the present invention: nontoxic, non-stimulated, no burn into environmental protection, safe and reliable.
Wherein: 1, the true border of acute oral toxicity (LD50) test is nontoxic;
2, the PCEMNR micronucleus test is negative;
3, subacute toxicity test does not produce obvious toxic-side effects to the every observation index of rat;
4, the skin irritation test belongs to nonirritant;
5, eye irritant test belongs to nonirritant;
6, the vaginal mucosa irritant test belongs to utmost point subexcite;
7, the damaged skin irritant test belongs to utmost point subexcite;
8, arsenic, lead content and corrosivity all meet national toxicology safety index.
The present invention has with respect to existing disinfection solution that the sterilization kind is many, sterilizing rate is high, manufacturing process is simple, cost is low, be applied to poultry curative effect location clearly, safe and reliable characteristics.
When the present invention uses,, dilute in proportion with tap water by the application target requirement, now with the current.
Compared with prior art, the present invention is exclusively used in pathogenic bacteria, the virus of killing fowl poultry kind, owing to adopted the non-antibiotic material in the component, to poultry fur, oral cavity, endometrium and vagina, the therapeutic efficiency that non-antibiotic medicament is arranged, to the treatment cow endometritis, can not produce milk and contain anti-.Nontoxic during use, non-stimulated, do not have corrosion, be a kind of novel built bactericidal agent of environment-friendly type, for health, the fast development of modernized animal husbandry economy provides guarantee.
The specific embodiment
Embodiment 1: get 0.01 part of chlorhexidine acetate, 0.002 part of Triton X-100,99.958 parts in tap water, put into container, after the mixing and stirring, be heated to 65 ℃, add 0.02 part of benzalkonium chloride again, and be heated with stirring to 92 ℃, and then be cooled to 18 ℃, and 0.01 part of adding of glutaraldehyde is stirred, the reuse sodium hydroxide is adjusted pH value, making pH value is 6, promptly makes.
Embodiment 2: get 5 parts of chlorhexidine acetates, 10 parts of Triton X-100s, 63 parts in tap water, put into container, after the mixing and stirring, be heated to 70 ℃, add 12 parts of benzalkonium chlorides again, and be heated with stirring to 94 ℃, and then be cooled to 26 ℃, and 10 parts of addings of glutaraldehyde are stirred, the reuse sodium bicarbonate is adjusted pH value, making pH value is 10, promptly makes.
Embodiment 3: get 1 part of chlorhexidine acetate, 1 part of Triton X-100,96 parts in tap water, put into container, after the mixing and stirring, be heated to 68 ℃, add 1 part of benzalkonium chloride again, and be heated with stirring to 93 ℃, and then be cooled to 22 ℃, and 1 part of adding of glutaraldehyde is stirred, the reuse sodium bicarbonate is adjusted pH value, making pH value is 8, promptly makes.
Embodiment 4: get 1.5 parts of chlorhexidine acetates, 0.2 part of Triton X-100,96.1 parts in tap water, put into container, after the mixing and stirring, be heated to 67 ℃, add 1.2 parts of benzalkonium chlorides again, and be heated with stirring to 93 ℃, and then be cooled to 21 ℃, and 1 part of adding of glutaraldehyde is stirred, the reuse sodium bicarbonate is adjusted pH value, making pH value is 7, promptly makes.
Embodiment 5: get 3 parts of chlorhexidine acetates, 0.3 part of Triton X-100,93.3 parts in tap water, put into container, after the mixing and stirring, be heated to 69 ℃, add 2.5 parts of benzalkonium chlorides again, and be heated with stirring to 92 ℃, and then be cooled to 25 ℃, and 0.9 part of adding of glutaraldehyde is stirred, the reuse sodium hydroxide is adjusted pH value, making pH value is 9, promptly makes.
Claims (3)
1. poultry special sterilizing medicament, it is characterized in that forming: 0.01～5 part of chlorhexidine acetate, 0.002～10 part of Triton X-100,0.02～12 part of benzalkonium chloride by following substances in parts by weight, 0.01～10 part of glutaraldehyde, 63～99.958 parts in tap water.
2. the manufacture method of poultry special sterilizing medicament as claimed in claim 1, it is characterized in that: get 0.01～5 part of chlorhexidine acetate, 0.002～10 part of Triton X-100,63～99.958 parts in tap water, put into container, after the mixing and stirring, be heated to 65～70 ℃, add 0.02～12 part of benzalkonium chloride again, and be heated with stirring to 92～94 ℃, and then be cooled to 18～26 ℃, 0.01～10 part of adding of glutaraldehyde is stirred, reuse sodium hydroxide or sodium bicarbonate are adjusted pH value, and making pH value is 6～10, promptly makes.
3. the purposes of a poultry special sterilizing medicament as claimed in claim 1 or 2 is characterized in that: the sterilizing that is exclusively used in poultry fur, oral cavity, endometrium, interior pudendum, breast, colony house, air and body surface.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011101475894A CN102266314A (en) | 2011-06-02 | 2011-06-02 | Sterilization agent special for livestock and preparation method and application thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011101475894A CN102266314A (en) | 2011-06-02 | 2011-06-02 | Sterilization agent special for livestock and preparation method and application thereof |
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| CN102266314A true CN102266314A (en) | 2011-12-07 |
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| CN2011101475894A Pending CN102266314A (en) | 2011-06-02 | 2011-06-02 | Sterilization agent special for livestock and preparation method and application thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102626403A (en) * | 2012-03-14 | 2012-08-08 | 北京万海康医科技有限公司 | Disinfectant for animals and its preparation method and use |
| CN103081940A (en) * | 2013-02-05 | 2013-05-08 | 河南科技学院 | Compound chlorhexidine acetate microemulsion disinfectant and its preparation method |
| CN103202826A (en) * | 2013-04-18 | 2013-07-17 | 江苏健裕健康医疗器械有限公司 | Benzalkonium chloride and sodium bicarbonate composite disinfectant |
| CN109221117A (en) * | 2018-09-19 | 2019-01-18 | 青岛安特斯生物制药有限公司 | A kind of pet deodorization bacteria-removing liquid and its preparation and application |
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| CN1242418A (en) * | 1998-06-29 | 2000-01-26 | 上海医南药业有限公司 | Sterilizing detergent and method for preparing same |
| CN1729778A (en) * | 2005-08-18 | 2006-02-08 | 刘震 | Sterilizing agent, preparation method and use thereof |
| CN101940577A (en) * | 2010-09-27 | 2011-01-12 | 崔秀梅 | Compound-type aqueous multiple-effect environmentally-friendly bactericide as well as preparation method and applications thereof |
-
2011
- 2011-06-02 CN CN2011101475894A patent/CN102266314A/en active Pending
Patent Citations (3)
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| CN1242418A (en) * | 1998-06-29 | 2000-01-26 | 上海医南药业有限公司 | Sterilizing detergent and method for preparing same |
| CN1729778A (en) * | 2005-08-18 | 2006-02-08 | 刘震 | Sterilizing agent, preparation method and use thereof |
| CN101940577A (en) * | 2010-09-27 | 2011-01-12 | 崔秀梅 | Compound-type aqueous multiple-effect environmentally-friendly bactericide as well as preparation method and applications thereof |
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| 《广东奶业》 20100430 廖陶雪，等 兽医常用消毒药及其合理运用 第23页左栏第1段，第24页左栏第36行至右栏第9行，第26页右栏第36行至第27页左栏第25行 3 , 第4期 * |
| 廖陶雪，等: "兽医常用消毒药及其合理运用", 《广东奶业》, no. 4, 30 April 2010 (2010-04-30) * |
| 魏秋华，等: "禽流感病毒生物学及其消毒与防护进展", 《中国消毒学杂志》, vol. 22, no. 1, 31 December 2005 (2005-12-31), pages 91 - 94 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102626403A (en) * | 2012-03-14 | 2012-08-08 | 北京万海康医科技有限公司 | Disinfectant for animals and its preparation method and use |
| CN103081940A (en) * | 2013-02-05 | 2013-05-08 | 河南科技学院 | Compound chlorhexidine acetate microemulsion disinfectant and its preparation method |
| CN103081940B (en) * | 2013-02-05 | 2014-06-18 | 河南科技学院 | Compound chlorhexidine acetate microemulsion disinfectant and its preparation method |
| CN103202826A (en) * | 2013-04-18 | 2013-07-17 | 江苏健裕健康医疗器械有限公司 | Benzalkonium chloride and sodium bicarbonate composite disinfectant |
| CN109221117A (en) * | 2018-09-19 | 2019-01-18 | 青岛安特斯生物制药有限公司 | A kind of pet deodorization bacteria-removing liquid and its preparation and application |
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Application publication date: 20111207 |