CN102266270A - Mosquito repelling agent - Google Patents
Mosquito repelling agent Download PDFInfo
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- CN102266270A CN102266270A CN 201010191632 CN201010191632A CN102266270A CN 102266270 A CN102266270 A CN 102266270A CN 201010191632 CN201010191632 CN 201010191632 CN 201010191632 A CN201010191632 A CN 201010191632A CN 102266270 A CN102266270 A CN 102266270A
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Abstract
The invention discloses a mosquito repelling agent by using icaridin as an effective component. The mosquito repelling agent comprises the following components in percentage by weight: 5-25 percent of icaridin, 10-80 percent of organic matters, 0.1-10 percent of organic acid, 0.1-1 percent of essence, and the balance of water. The mosquito repelling agent has the advantages of simple composed components, clear effect of each component, no irritation and environmental friendliness. According to the invention, the staying period of the mosquito repelling agent on the skin surface can be effectively prolonged, and the mosquito repelling agent is prevented from penetrating the skin, so that hurt to a human body is reduced. The mosquito repelling agent can be made into a spraying agent, emulsion, ointment, soft or hard solid cerate and other various preparations, and can be applied indoors or outdoors to achieve the aim of effectively repelling mosquitoes.
Description
Technical field
The present invention relates to a kind of is the mosquito-repellent of effective ingredient with hydroxyl piperazine ester.
Background technology
The very big disease of many in the world harm is that invasion by small insects such as mosquitos and flies causes as malaria, yellow fever, dengue fever etc. mostly, and mosquitos and flies bites can cause on a large scale or large-area transmission of disease or cause the popular of eqpidemic disease.Administer environment, reduce the soil that grows mosquito, in the city, can carry out.But in the wild environment of nature, the existence of mosquito is necessary, because they are a member in the biological chain; Therefore, mosquito is inevitable the existence in the environment of green trees in the open air.How to prevent that mosquito bite from being an important research project always.
In the mankind's civilized process, the mankind are seeking mosquito-repellent always, the mankind at first take from nature, people also are with a certain amount of natural materials mosquito repellent in use to this day, for example terpinol, primrose oil, Fructus Citri Limoniae oil, Oleum Pelargonii Graveolentis, Cedrus deoclar (Roxb.) G. Don oil, tea tree oil, Eucalyptus oil, and birds extract and Oleum Bulbus Allii or Bulbus Allii extract.The scientist of a lot of countries in the whole world is devoted to the exploitation of anophelifuge anophelifuge material for a long time, to reduce the harm that mosquito bite brings to the mankind.But the research work progress of this respect is still slow by nineteen nineties, has developed 1953 just that a putative effective product---diethyltoluamide, its Main Ingredients and Appearance are N, N-n,N-diethyl meta-toluamide, vehicle economy ET.Though DEET be used since nearly half a century the most extensively, the repellant of safety under dosage usually, but still every now and then relevant for the toxicity report of DEET, as long-term or a large amount of uses neurological symptom, skin lesion, child's anaphylaxis etc. can appear.The child uses the product that contains DEET, and whether safety is still disputable, and the suggestion child of U.S. department of pediatrics association does not want the product that working concentration is higher than 10%DEET.Another fatal shortcoming of DEET is its plasticizer properties.It damages many modern synthesized polymer materials, and for example the synthetic fibers material is moulded system eyeglass frames and wrist-watch, the high-molecular coating on the surface of automobile and furniture or the like.Therefore, use the product that contains DEET careful, especially use the army of numerous sophisticated weapons and instrument, open-air People's Armed Police on duty and the people of police and the outing of use automobile, more should significant care.
Hydroxyl piperazine ester, its chemical name are 2-(2-ethoxy)-piperidines-1-carbonic acid-1-methyl isopropyl esters, and its chemical structural formula is:
U.S. chemical abstract 119515-38-7; Molecular formula C
12H
23NO
3Molecular weight 229.3g/mol; 296 ℃ of boiling points.
Hydroxyl piperazine ester is colourless or little yellow liquor body, slight cosmetics fragrance is arranged, apply in the human body skin surface feel comfortable, nonirritant, at many national registrations such as Europe, North America, South America, Australia, part national registration in Asia and Africa is as in Japan, Canada, the U.S., Australia etc.The outstanding feature of this chemical compound is extremely low toxicity, and Environmental Protection Agency is regarded as three grades, and human body is not had injury, imposes the equal area skin surface with same dose, and greater than 30%, and hydroxyl piperazine ester is less than 5% to absorption by human body for DEET.And the effect of hydroxyl piperazine ester preventing bite of mosquito is really good than DEET, and use amount is significantly less than DEET, but can protect the longer time.Beyer Co., Ltd is an active component with this chemical compound, has carried out research for a long time, develops novel the drive mosqito repellent better than DEET, can protect more effectively, and human body is not bitten by mosquitos and flies, and away from the infection and the propagation of malaria disease.At present, with hydroxyl piperazine ester exploitation drive mosqito repellent be the unique approval of World Health Organization (WHO) human body is effectively driven mosqito repellent.
But the composition of the hydroxyl piperazine ester formulation of developing at present is all quite complicated, and its component is tens kinds of chemical substances at most, and nearly ten kinds of chemical substances are formed at least.With regard to people and chemical substance, any chemical substance all is a foreign body to human body, and it is more harm than good entering the normal human.Too much use chemical substance also is a kind of pollution to environment simultaneously.Therefore exploitation simple, easily row, effectively hydroxyl piperazine ester drives the mosqito repellent novel form, be one to mankind itself and work that the environment of human survival all is significant.
Summary of the invention
The present invention will provide a kind of composition simple, clear and definite, non-stimulated, the eco-friendly mosquito-repellent of each composition effect.
The weight content of each component is in the described mosquito-repellent: 5～25% hydroxyl piperazine ester, and 10～80% organic substances, 0.1～10% organic acid, 0.1～1% essence, surplus is a water.
Described organic substance can be C
2～C
4Can with the polymer of the miscible organic alcohol of water or organic alcohol at least a, the polymer of described organic alcohol or organic alcohol is selected from least a in ethanol, propanol, isopropyl alcohol, propylene glycol, glycerol, butanediol and the Polyethylene Glycol.
Described organic substance can also be following film forming matter: at least a in poly-dialkyl organic siliconresin or the polyurethane, or be vaseline; Described film forming matter shared part by weight in mosquito-repellent is 1%-30%.Above-mentioned poly-dialkyl organic siliconresin is at least a in 110 methyl ethylene silicone adhesives, hexamethyl disiloxane, octamethyltrisiloxane, decamethylcyclopentaandoxane or the poly dimethyl oxosilane, and described polyurethane is soluble polyurethane graft acrylic acid emulsion.
Described organic substance can also be following chelating agent: at least a in ethylenediaminetetraacetic acid or tetrasodium ethylenediamine tetraacetate or the cyclodextrin; Described chelating agent shared part by weight in mosquito-repellent is 1%-15%.
Described organic substance is that following skin soaks into blocker: at least a in phosphatide cpd or the azone; It is 1.2～7% that described skin soaks into blocker shared part by weight in mosquito-repellent.Described phosphatide cpd is that weight concentration is 1～5% dimyristoyl phosphatidyl choline, and described azone is that weight concentration is 1-dodecyl-aza-cycloheptane alkane-2-ketone of 0.2～2%.
Described organic acid is selected from least a in the following material: acetic acid, propanoic acid, oxalic acid, citric acid, malic acid, cinnamic acid, Fumaric acid, lactic acid, sorbic acid, tartaric acid, succinic acid, gluconic acid, adipic acid, fumaric acid, ascorbic acid.
We are with C
2～C
4Alcohol consists of basic medium with water 5～25% hydroxyl piperazine esters is dissolved, adding a little organic acid then assists medium and hydroxyl piperazine ester to form hydrogen bond network, promptly stablize hydroxyl piperazine ester, increase the dissolubility of hydroxyl piperazine ester in medium again, the more important thing is formation by such hydrogen bond network, in the time of can reducing hydroxyl piperazine ester and spray from container and spray to evaporation rate later on the skin, prolong its repellent mosquito effect.This preparation seldom is generally 0.1～1% to the demand of essence.Top preparation most preferred dosage form is the spray agent, makes simply, carries with easy to use.
Film forming matter of the present invention has the ability of formation " tangible " or " invisible " film; like this after mosquito-repellent is smeared or is sprayed onto on the skin; they form layer protecting film at skin surface; can make mosquito-repellent be trapped in the sufficiently long time of skin surface effectively, stop mosquito-repellent to soak into skin again simultaneously.The skin part of exposure is smeared or be sprayed to the mosquito-repellent that contains " tangible " film forming matter, and a kind of flexible membrane of very fast formation does not influence activity; especially on hand; do not influence normal activity and work, in case finish the period that exposes, the tangible film of this layer can be shut down.Mosquito-repellent is to fuse in this tangible film, with between the film forming matter without any the formation of chemical bond, therefore, do not influence them and from film, come out, reach the effect of repellent mosquito.The inventor is by discovering poly-dialkyl organic siliconresin many times and polyurethane is the most suitable makes this tangible film preparation with hydroxyl piperazine ester compatibility.Shou Xuan poly-dialkyl organic siliconresin wherein is as 110 methyl ethylene silicone adhesives, hexamethyl disiloxane, octamethyltrisiloxane, decamethylcyclopentaandoxane or poly dimethyl oxosilane etc.Described polyurethane is soluble polyurethane graft acrylic acid emulsion (being called for short PUA).The mosquito-repellent Emulsion greasy that adds the organic siliconresin gained is felt to diminish, and silk-like handle and lubricity enhancing are more suitable in smearing in face and hand.
The mosquito-repellent that utilizes poly-dialkyl organic siliconresin and polyurethane manufacturing to have " tangible " film forming ability is fit to variform, can be the agent of spray quinoline, because the ratio that soluble polyurethane and above-mentioned mosquito-repellent can any needs is mixed; Also can be Emulsion or unguentum.The advantage of this preparation is to be suitable for using outdoor or field man for a long time, because it is longer to have formed the tangible film repellent mosquito time, protects effective.
Mosquito-repellent with fluidization " invisible " film forming ability has not only been brought into play the advantage of above-mentioned tangible film preparation, is suitable for the needs of any length time user, has brought convenience simultaneously, because it when the protection period finishes, can rinse out by water at any time.The invisible film preparation of fluidization; contain a kind of with not infiltration mutually of skin; can not soak into the film forming matter (claiming substrate again) of skin; after on being applied to skin surface; this substrate forms a kind of film of invisible liquid at skin surface; protection skin reduces and prevents the same contact skin of mosquito-repellent in the preparation, reduces mosquito-repellent and is impregnated in the skin.The substrate for preparing the invisible film mosquito-repellent of this fluidization is generally based on vaseline class material, and preparation is simple, and is easy to use, generally is in proportion vaseline, mosquito-repellent and other necessary excipient to be mixed in proportion, and bottling is used.The advantage of this dosage form is again mosquito-repellent to be arrested in outside the skin by delaying the evaporable speed of mosquito-repellent, reinforced effects, reduces the infringement to human body, simultaneously, this dosage form is easy to use, can use at any time as required, rinses out at any time.
Chelating agent of the present invention and hydroxyl piperazine ester form one or more complexations or complexation macromole by complex bonds, and hydroxyl piperazine ester is trapped in the preparation medium, can not soak into skin.Because complex bonds is not permanent covalent bond, can not stop the abnormal smells from the patient of hydroxyl piperazine ester to be dispersed fully, therefore, can not change the chemistry ownership that hydroxyl piperazine ester drives mosqito repellent.The chelating agent that can form complex bonds with hydroxyl piperazine ester that adopts among the present invention be ethylenediaminetetraacetic acid (ethylenediaminetetraacetic acid), tetrasodium ethylenediamine tetraacetate (ethylenediaminetetraacetic acid-Na) and at least a in the cyclodextrin (English name cyclodextrin).Complexation generally makes by complex bonds or intermolecular affinity and drives mosqito repellent and be solidificated in certain scope and can not move easily, just reduce moving to the skin direction, minimizing is with the chance and the time of contact skin, thereby reduce the chance of soaking in skin, minimizing is driven mosqito repellent and is impregnated in the skin and may produces unnecessary burden and toxic and side effects to human body.The selection of chelating agent is by the decision of the chemical constitution of hydroxyl piperazine ester, power supplying groups is generally all arranged in the structure of hydroxyl piperazine ester, for example :-N-C=O,-C-O-,-C-O-H, therefore can easily add in the preparation according to the ratio of power supply and suction, electric group and choice of location, make it form the fused body that conditions each other by complex bonds or hydrogen bond with hydroxyl piperazine ester with the chelating agent that these power supplies or electron-withdrawing group form complex bonds or hydrogen bond.Because the final preparation of hydroxyl piperazine ester generally is based on water-soluble base, how to make fat-soluble hydroxyl piperazine ester can in water-soluble base, make a concerted effort to disperse, can make it not be impregnated into skin again: the present invention adopts amphiprotic substance, i.e. ethylenediaminetetraacetic acid, tetrasodium ethylenediamine tetraacetate and cyclodextrin.The existing water miscible characteristics of these materials, but itself has fat-soluble cave again, be used to load fat-soluble hydroxyl piperazine ester, these materials can make hydroxyl piperazine ester be evenly dispersed in the preparation, again it is fixed on simultaneously certain zone, it can not be moved easily reduce same contact skin, increase the human body burden and human body is produced toxic and side effects thereby can not soak into skin.Cyclodextrin is structure in the form of a ring, and hydrophilic hydroxyl is distributed in the periphery of ring, forms hydrophilic shell, so cyclodextrin can be molten with water; The ring heart of cyclodextrin is the hole, be to form by lipophilic hydrocarbon backbone, therefore the hole is fat-soluble, so fat-soluble material will be embedded in the fat-soluble hole with the cyclodextrin contact, the effect that the rendered fat dissolubility drives mosqito repellent has been played in this hole, make and drive mosqito repellent and can not soak into skin, cause unnecessary human injury with what contact skin too much caused.This formulation preparation method is simple, is fit to commercial production, and a certain proportion of mosqito repellent, cyclodextrin and other necessary excipient of driving is mixed in proportion, and stirs, and bottling is used.
Skin of the present invention soaks into blocker, they can be by changing the rigidity that skin histology interval material becomes retardance or passes through to increase the lipid material in the keratodermatitis, or the retardance character that increases lipid material realizes blocking foreign substance and soaks into skin, the classification that skin soaks into blocker is the thing of a more complicated, because some materials play the effect that skin absorbs promotes to a kind of material, but may be to play the skin absorbs retardation to another material.What use in the present invention is that skin soaks into blocker two kinds is arranged, and first kind is a phosphatide cpd, and for example weight concentration is the dimyristoyl phosphatidyl choline (being called for short DMPC) of 1-5%; Another is synthetic azone, and for example weight concentration is 1-dodecyl-aza-cycloheptane alkane-2-ketone (being called for short Azone) of 0.2-2%, and its structural formula is:
Mosquito-repellent of the present invention can be made Emulsion and unguentum except being processed into the spray agent.By spraying and smearing repellant is spread upon on the skin, produce the unacceptable abnormal smells from the patient of mosquito, reach the effect of anophelifuge and anophelifuge.On making, only need to increase emulsifying agent such as span, tween, tridecyl sodium stearate, sulfosuccinate, tristerin; With other necessary excipient such as Wool wax alcohols,ethoxylated, lanoline, acrylate polymer C
10-30, apricot glue; Antiseptic such as tridecyl benzenetricarboxylic acid potassium; Wetting agent such as simethicone, Aloe crude extract etc.
Mosquito-repellent of the present invention can also be made another kind of soft or hard shape solid cerate.Hydroxyl piperazine ester is evenly dispersed in the solid carrier, for example paraffin, palm wax, Apis cerana Fabricius and high molecular polymer etc.Soft cured shape solid preparation will form thin film at skin surface by rubbing, the hydroxyl piperazine ester that is dispersed in the solid carrier volatilizees slowly, the effect of performance mosquito repellent is simultaneously because therefore contacting seldom of hydroxyl piperazine ester and skin be suitable for the extremely people's use of sensitivity of those skins.Simultaneously this soft cured shape solid preparation can be made variform fritter, is placed on indoor anophelifuge, also can be through to become chain to hang over position that the neck of animal pets such as Canis familiaris L., cat, domestic animal or the like and other can bolt hang with mosquito repellent together.
Mosquito-repellent of the present invention can also be made other dosage form to be suitable for the use of varying environment, oiliness agent for example, with Oleum Caryophylli, Oleum Brassicae campestris, citronella oil, patchouli oil, cade oil is substrate, be used for the area of heavy rainfull, to reduce the flushing that rainwater drives mosqito repellent to hydroxyl piperazine ester, keep repellent mosquito effect.Aerosol is a substrate with low boiling point organic solvent propane, butane etc., is used for privileged sites such as hair, and sneaking into the hair style agent promptly can mosquito repellent, also can play hair strengthening effect attractive in appearance.Cream is applied to face's privileged sites such as around eyes, ear lip, mixes with skin protection, wetting agent both to play skin protection and also play repellent mosquito effect.
The specific embodiment
Below by specific embodiment technical scheme of the present invention is described in further detail.Each embodiment has all provided composition with each the component different content in a kind of dosage form with the form of form, and percentage composition wherein all refers to the weight content in total amount.
Embodiment 1. spray agent
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | |
| Hydroxyl piperazine ester | 5g | 7g | 10g | 12g | 15g | 18g | 20g | 22g | 25g |
| Ethanol | 10ml | 15ml | 20ml | 20ml | 25ml | 25ml | 25ml | 25ml | 25ml |
| Isopropyl alcohol | 14ml | 16ml | 18ml | 20ml | 22ml | 23ml | 23ml | 24ml | 24ml |
| Citric acid | 15mg | 20mg | 22mg | 23mg | 24mg | 25mg | 26mg | 27mg | 28mg |
| Essence | 0.5％ | 0.5％ | 0.5％ | 0.5％ | 0.5％ | 0.5％ | 0.5％ | 0.5％ | 0.5％ |
| Distilled water | 79.5ml | 61.5ml | 51.5ml | 47.5ml | 37.5ml | 33.5ml | 31.5ml | 29.5ml | 25.5ml |
Embodiment 2. spray agent
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | |
| Hydroxyl piperazine ester | 5g | 7g | 10g | 12g | 15g | 18g | 20g | 22g | 25g |
| Ethanol | 10ml | 15ml | 20ml | 20ml | 25ml | 25ml | 25ml | 25ml | 25ml |
| Isopropyl alcohol | 14ml | 16ml | 18ml | 20ml | 22ml | 23ml | 23ml | 24ml | 24ml |
| Citric acid | 15mg | 20mg | 22mg | 23mg | 24mg | 25mg | 26mg | 27mg | 28mg |
| Vaseline | 2g | 3g | 5g | 6g | 8g | 9g | 10g | 11g | 12g |
| Essence | 0.5％ | 0.5％ | 0.5％ | 0.5％ | 0.5％ | 0.5％ | 0.5％ | 0.5％ | 0.5％ |
| Distilled water | 68.5ml | 58.5ml | 46.5ml | 41.5ml | 29.5ml | 24.5ml | 21.5ml | 17.5ml | 13.5ml |
Embodiment 3. spray agent
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | |
| Hydroxyl piperazine ester | 5g | 7g | 10g | 12g | 15g | 18g | 20g | 22g | 25g |
| Ethanol | 10ml | 15ml | 20ml | 20ml | 25ml | 25ml | 25ml | 25ml | 25ml |
| Isopropyl alcohol | 14ml | 16ml | 18ml | 20ml | 22ml | 23ml | 23ml | 24ml | 24ml |
| Citric acid | 15mg | 20mg | 22mg | 23mg | 24mg | 25mg | 26mg | 27mg | 28mg |
| EDTA | 0.1g | 0.2g | 0.3g | 0.4g | 0.5g | 0.6g | 0.7g | 0.8g | 1.0g |
| Cyclodextrin | 5g | 5g | 6g | 6g | 7g | 7g | 8g | 9g | 10g |
| Essence | 0.5％ | 0.5％ | 0.5％ | 0.5％ | 0.5％ | 0.5％ | 0.5％ | 0.5％ | 0.5％ |
| Distilled water | 65.5ml | 56.5ml | 45.5ml | 41ml | 30ml | 26ml | 23ml | 19.ml | 14.5ml |
Embodiment 4. spray agent
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | |
| Hydroxyl piperazine ester | 5g | 7g | 10g | 12g | 15g | 18g | 20g | 22g | 25g |
| Ethanol | 10ml | 15ml | 20ml | 20ml | 25ml | 25ml | 25ml | 25ml | 25ml |
| Isopropyl alcohol | 14ml | 16ml | 18ml | 20ml | 22ml | 23ml | 23ml | 24ml | 24ml |
| Citric acid | 15mg | 20mg | 22mg | 23mg | 24mg | 25mg | 26mg | 27mg | 28mg |
| Polyurethane E | 0.1g | 0.5g | 1.0g | 1.5g | 2.0g | 3.0g | 4.0g | 5.0g | 6.0g |
| Silicone adhesive | 0.5g | 1.0g | 1.5g | 2.0g | 2.5g | 3.5g | 4.5g | 5.5g | 7.0g |
| Essence | 0.5％ | 0.5％ | 0.5％ | 0.5％ | 0.5％ | 0.5％ | 0.5％ | 0.5％ | 0.5％ |
| Distilled water | 70ml | 60ml | 50ml | 44ml | 33ml | 27ml | 23ml | 18ml | 13ml |
Embodiment 5. Emulsions
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | |
| Hydroxyl piperazine ester | 5g | 7g | 10g | 12g | 15g | 18g | 20g | 22g | 25g |
| Ethanol | 10ml | 15ml | 20ml | 20ml | 25ml | 25ml | 25ml | 25ml | 25ml |
| Glycerol | 1ml | 2ml | 3ml | 4ml | 5ml | 6ml | 7ml | 8ml | 9ml |
| The tridecyl sodium stearate | 0.5g | 0.7g | 1.0g | 1.2g | 1.5g | 1.8g | 2.0g | 2.2g | 2.5g |
| Tridecyl benzenetricarboxylic acid potassium | 0.3g | 0.3g | 0.5g | 0.5g | 0.8g | 0.8g | 1.0g | 1.0g | 1.2g |
| The melissyl erithritol | 0.5g | 0.7g | 1.0g | 1.2g | 1.5g | 1.8g | 2.0g | 2.2g | 2.5g |
| Acrylate polymer C 10-30 | 1g | 1g | 1g | 1.5g | 1.5g | 1.5g | 2g | 2g | 2g |
| Essence | 0.5％ | 0.5％ | 0.5％ | 0.5％ | 0.5％ | 0.5％ | 0.5％ | 0.5％ | 0.5％ |
| Distilled water | 81.5ml | 73.0ml | 63.0ml | 59.5ml | 50.0ml | 45.0ml | 41.0ml | 37.5ml | 32.5ml |
Embodiment 6. Emulsions
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | |
| Hydroxyl piperazine ester | 5g | 7g | 10g | 12g | 15g | 18g | 20g | 22g | 25g |
| Ethanol | 10ml | 15ml | 20ml | 20ml | 25ml | 25ml | 25ml | 25ml | 25ml |
| Glycerol | 1ml | 2ml | 3ml | 4ml | 5ml | 6ml | 7ml | 8ml | 9ml |
| Sulfosuccinate | 0.5g | 0.5g | 1.0g | 1.0g | 1.0g | 1.5g | 1.5g | 1.5g | 1.5g |
| Wool wax alcohols,ethoxylated | 0.5g | 0.5g | 0.5g | 0.5g | 0.8g | 0.8g | 0.8g | 1.0g | 1.0g |
| Arlacel-20 | 0.5g | 0.5g | 0.5g | 0.5g | 1..0g | 1..0g | 1.0g | 1.0g | 1.5g |
| Tween-60 | 1g | 1g | 1g | 1g | 1.5g | 1.5g | 1.5g | 1.5g | 1.5g |
| Essence | 0.5％ | 0.5％ | 0.5％ | 0.5％ | 0.5％ | 0.5％ | 0.5％ | 0.5％ | 0.5％ |
| Distilled water | 81ml | 73ml | 63.5ml | 60.5ml | 50ml | 46ml | 43ml | 40ml | 35ml |
Embodiment 7. Emulsions
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | |
| Hydroxyl piperazine ester | 5g | 7g | 10g | 12g | 15g | 18g | 20g | 22g | 25g |
| Ethanol | 10ml | 15ml | 20ml | 20ml | 25ml | 25ml | 25ml | 25ml | 25ml |
| Glycerol | 1ml | 2ml | 3ml | 4ml | 5ml | 6ml | 7ml | 8ml | 9ml |
| Apricot glue | 1.5g | 1.5g | 2.0g | 2.0g | 2.5.g | 2.5g | 3.0g | 3.0.g | 3.5g |
| Simethicone | 0.5g | 0.5g | 1.0g | 1.0g | 1.5g | 1.5g | 2.0g | 2.0g | 2.5g |
| Arlacel-20 | 0.5g | 0.5g | 0.5g | 0.5g | 1..0g | 1..0g | 1.0g | 1.0g | 1.5g |
| Tween-60 | 1g | 1g | 1g | 1g | 1.5g | 1.5g | 1.5g | 1.5g | 1.5g |
| Essence | 0.5％ | 0.5％ | 0.5％ | 0.5％ | 0.5％ | 0.5％ | 0.5％ | 0.5％ | 0.5％ |
| Distilled water | 80ml | 72ml | 62ml | 59ml | 48ml | 44ml | 40ml | 37ml | 31.5ml |
Embodiment 8. cerates (soft solid)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | |
| Hydroxyl piperazine ester | 5g | 7g | 10g | 12g | 15g | 18g | 20g | 22g | 25g |
| Glycerol | 5ml | 4ml | 3ml | 2ml | 1.5ml | 1ml | 0.8ml | 0.5ml | 0.2ml |
| Palm wax | 68.5g | 62g | 52.5g | 47.2g | 41.5g | 33.8g | 27g | 20.8g | 12.5g |
| Apis cerana Fabricius | 15.5g | 20g | 25g | 28g | 30g | 33g | 35g | 37g | 40g |
| Lanoline | 0.5g | 0.7g | 1g | 1.2g | 1.5g | 1.8g | 2g | 2.2g | 2.5g |
| Vaseline | 5g | 6g | 8g | 9g | 10g | 12g | 15g | 17g | 20g |
| Essence | 0.5％ | 0.5％ | 0.5％ | 0.5％ | 0.5％ | 0.5％ | 0.5％ | 0.5％ | 0.5％ |
Embodiment 9. cerates (hard solid) (band agent or bottled)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | |
| Hydroxyl piperazine ester | 5g | 7g | 10g | 12g | 15g | 18g | 20g | 22g | 25g |
| Polyurethane E | 1g | 1.5g | 2.5g | 3.0g | 3.5g | 4.0g | 5.0g | 6.0g | 8.0g |
| Palm wax | 79.5g | 75.5g | 70g | 66g | 61g | 56g | 51.5g | 47g | 40.5g |
| Apis cerana Fabricius | 5g | 5.5g | 6g | 6.5g | 7g | 7.5g | 8g | 8.5g | 9g |
| The Aloe crude extract | 5g | 5g | 5g | 5g | 5g | 5g | 5g | 5g | 5g |
| Vaseline | 4g | 5g | 6g | 7g | 8g | 9g | 10g | 11g | 12g |
| Essence | 0.5％ | 0.5％ | 0.5％ | 0.5％ | 0.5％ | 0.5％ | 0.5％ | 0.5％ | 0.5％ |
Embodiment 10 unguentum
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | |
| Hydroxyl piperazine ester | 5g | 7g | 10g | 12g | 15g | 18g | 20g | 22g | 25g |
| Glycerol | 10ml | 10ml | 10ml | 10ml | 10ml | 10ml | 10ml | 10ml | 10ml |
| Tristerin | 6g | 6g | 6g | 6g | 6g | 6g | 6g | 6g | 6g |
| DMPC | 1％ | 1.5％ | 2.0％ | 2.5％ | 3.0％ | 3.5％ | 4.0％ | 4.5％ | 5.0％ |
| Vaseline | 5g | 5g | 5g | 5g | 5g | 5g | 5g | 5g | 5g |
| Liquid paraffin | 15ml | 15ml | 15ml | 15ml | 15ml | 15ml | 15ml | 15ml | 15ml |
| Citric acid | 22mg | 22mg | 22mg | 22mg | 22mg | 22mg | 22mg | 22mg | 22mg |
| Azone | 0.2％ | 0.4％ | 0.6％ | 0.8％ | 1.0％ | 1.2％ | 1.4％ | 1.6％ | 1.8％ |
| Essence | 0.5％ | 0.5％ | 0.5％ | 0.5％ | 0.5％ | 0.5％ | 0.5％ | 0.5％ | 0.5％ |
| 40% ethanol water | 57.5ml | 54.5ml | 51ml | 48.5ml | 44.5ml | 41ml | 38.5ml | 35.5ml | 32ml |
Claims (9)
1. mosquito-repellent, it is characterized in that: the weight content of each component is in the described mosquito-repellent: 5～25% hydroxyl piperazine ester, 10～80% organic substances, 0.1～10% organic acid, 0.1～1% essence, surplus is a water.
2. mosquito-repellent according to claim 1 is characterized in that: described organic substance is C
2～C
4Can with the polymer of the miscible organic alcohol of water or organic alcohol at least a.
3. mosquito-repellent according to claim 2 is characterized in that: the polymer of described organic alcohol or organic alcohol is selected from least a in ethanol, propanol, isopropyl alcohol, propylene glycol, glycerol, butanediol and the Polyethylene Glycol.
4. mosquito-repellent according to claim 1 is characterized in that: described organic substance is following film forming matter: at least a in poly-dialkyl organic siliconresin or the polyurethane, or be vaseline; Described film forming matter shared part by weight in mosquito-repellent is 1%-30%.
5. mosquito-repellent according to claim 4, it is characterized in that: described poly-dialkyl organic siliconresin is at least a in 110 methyl ethylene silicone adhesives, hexamethyl disiloxane, octamethyltrisiloxane, decamethylcyclopentaandoxane or the poly dimethyl oxosilane, and described polyurethane is soluble polyurethane graft acrylic acid emulsion.
6. mosquito-repellent according to claim 1 is characterized in that: described organic substance is following chelating agent: at least a in ethylenediaminetetraacetic acid or tetrasodium ethylenediamine tetraacetate or the cyclodextrin; Described chelating agent shared part by weight in mosquito-repellent is 1%-15%.
7. mosquito-repellent according to claim 1 is characterized in that: described organic substance is that following skin soaks into blocker: at least a in phosphatide cpd or the azone; It is 1.2～7% that described skin soaks into blocker shared part by weight in mosquito-repellent.
8. mosquito-repellent according to claim 7, it is characterized in that: described phosphatide cpd is that weight concentration is 1～5% dimyristoyl phosphatidyl choline, and described azone is that weight concentration is 1-dodecyl-aza-cycloheptane alkane-2-ketone of 0.2～2%.
9. mosquito-repellent according to claim 1 is characterized in that: described organic acid is selected from least a in the following material: acetic acid, propanoic acid, oxalic acid, citric acid, malic acid, cinnamic acid, Fumaric acid, lactic acid, sorbic acid, tartaric acid, succinic acid, gluconic acid, adipic acid, fumaric acid, ascorbic acid.
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| CN 201010191632 CN102266270B (en) | 2010-06-04 | 2010-06-04 | Mosquito repelling agent |
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| CN 201010191632 CN102266270B (en) | 2010-06-04 | 2010-06-04 | Mosquito repelling agent |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104621099A (en) * | 2015-01-29 | 2015-05-20 | 宁波远鸿生物科技有限公司 | Preparation method of mosquito-repelling preserved flowers |
| CN105726416A (en) * | 2016-04-09 | 2016-07-06 | 福建省金鹿日化股份有限公司 | Gel with mosquito repelling, swelling subsiding and itching relieving functions |
| CN106614671A (en) * | 2016-12-28 | 2017-05-10 | 安徽紫檀科技有限公司 | Safe and environment-friendly mosquito repellent liquid and preparation method thereof |
| CN106852339A (en) * | 2015-12-09 | 2017-06-16 | 历佳化工有限公司 | A kind of pesticide ointment and preparation method thereof |
| CN110538082A (en) * | 2019-09-17 | 2019-12-06 | 江西农业大学 | Efficient mosquito repelling method by associating terpenoid repellent and attractant supermolecule |
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| CN1217633A (en) * | 1996-05-06 | 1999-05-26 | 拜尔公司 | Arthropod repellant |
| US20060153891A1 (en) * | 2001-12-26 | 2006-07-13 | Gonzalez Anthony D | Meta-stable insect repellent emulsion composition and method of use |
| WO2007050653A2 (en) * | 2005-10-25 | 2007-05-03 | Avon Products, Inc. | Water resistant sunscreen and insect repellent composition |
| WO2008024738A2 (en) * | 2006-08-25 | 2008-02-28 | Avon Products, Inc. | A water based clear sunscreen and insect repellent composition |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1217633A (en) * | 1996-05-06 | 1999-05-26 | 拜尔公司 | Arthropod repellant |
| US20060153891A1 (en) * | 2001-12-26 | 2006-07-13 | Gonzalez Anthony D | Meta-stable insect repellent emulsion composition and method of use |
| WO2007050653A2 (en) * | 2005-10-25 | 2007-05-03 | Avon Products, Inc. | Water resistant sunscreen and insect repellent composition |
| WO2008024738A2 (en) * | 2006-08-25 | 2008-02-28 | Avon Products, Inc. | A water based clear sunscreen and insect repellent composition |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104621099A (en) * | 2015-01-29 | 2015-05-20 | 宁波远鸿生物科技有限公司 | Preparation method of mosquito-repelling preserved flowers |
| CN104621099B (en) * | 2015-01-29 | 2016-05-04 | 宁波远鸿生物科技有限公司 | A kind of preparation method of mosquito repellent preserved flower |
| CN106852339A (en) * | 2015-12-09 | 2017-06-16 | 历佳化工有限公司 | A kind of pesticide ointment and preparation method thereof |
| CN105726416A (en) * | 2016-04-09 | 2016-07-06 | 福建省金鹿日化股份有限公司 | Gel with mosquito repelling, swelling subsiding and itching relieving functions |
| CN106614671A (en) * | 2016-12-28 | 2017-05-10 | 安徽紫檀科技有限公司 | Safe and environment-friendly mosquito repellent liquid and preparation method thereof |
| CN106614671B (en) * | 2016-12-28 | 2019-08-23 | 安徽紫檀科技有限公司 | Mosquito repellent liquid and preparation method thereof |
| CN110538082A (en) * | 2019-09-17 | 2019-12-06 | 江西农业大学 | Efficient mosquito repelling method by associating terpenoid repellent and attractant supermolecule |
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| Publication number | Publication date |
|---|---|
| CN102266270B (en) | 2013-01-30 |
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