CN102266240B - Acoustic-electric joint analysis device used for tumor detection - Google Patents
Acoustic-electric joint analysis device used for tumor detection Download PDFInfo
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Abstract
The invention provides an acoustic-electric joint analysis device used for detection. The device comprises a signal source excitation module, a detection signal receiving and transmitting module, a data acquisition module, an imaging module and an image joint analysis module which are connected in turn. The analysis device can simultaneously transmit a high-frequency ultrasonic signal and an ultra wide band (UWB) electromagnetic wave signal to detect human tissues, perform signal processing and imaging algorithm processing after receiving backward waves to respectively obtain grey-scale maps about the ultrasonic signal and the electromagnetic wave signal, and finally perform comprehensive processing and analysis on the two grey-scale maps. More detection details can be acquired and more accurate pathological analysis can be made by complementing the high specificity of ultrasonic imaging and the high sensitivity of the UWB electromagnetic wave imaging.
Description
Technical field
The invention belongs to medical science Detection Techniques field, be specifically related to ultra sonic imaging, ultra broadband imaging, complementary series coded pulse detection and image association analytical equipment.
Background technology
Cancer is frequently-occurring disease and the commonly encountered diseases of a class serious threat human health.Over nearly 30 years, cancer morbidity and mortality rate are always in rising trend.Related data shows that tumor has become one of major causes of death of China resident, resists the form severe of cancer.
Although the tumor Medical Technology of constantly updating has been gathered the various means such as operation, radiotherapy, chemotherapy, biological gene, be middle and advanced stage when finding cancer owing to the most tumors patient, good Therapeutic Method also can only be felt frustrated again.So, how correctly to diagnose out in early days tumor in cancer, for plenty of time is won in treatment, just become the key point that can cure tumor.
At present, medically had several different methods tumor has been detected and imaging, such as X-ray, computed tomography, NMR (Nuclear Magnetic Resonance)-imaging, ultrasound detection and ultra broadband Near-Field Radar Imaging technology etc.X-ray is lower for the sensitivity without the infantile tumour of calcification, thus detect error rate and loss all higher, and repeatedly accept the X-ray irradiation and can cause ionizing radiation to gather in vivo, might cause the normal structure canceration.Computed tomography and X-ray exist same problem: the radiation of tomoscan can penetration cell, destroy DNA, even brings out some cancerous cell.Although nuclear magnetic resonance technique does not have harmful effect to human body, its spatial resolution is not as good as computed tomography, and equipment cost is expensive, is not suitable for large-scale mass survey.Yet the performance of two kinds of technology of ultra sonic imaging and ultra broadband (UWB) imaging is comparatively desirable.
Ultrasonic imaging technique is whether the decay according to ultrasonic echo detects and have abnormal structure to exist.Ultrasonic in medium with straightline propagation, good directivity is arranged, this is the basis of detecting with Ultrasound on Human tissue or organ.When ultrasound wave arrives the interface of the different adjacent media of two kinds of acoustic impedances, will reflect, and acoustic impedance difference is larger, volume reflection is also larger.Acoustic impedance is defined as: Z=P*C, and P is Media density in the formula, C is the velocity of sound in the tissue.Generally speaking, the spread speed of the velocity of sound in tissue changes little, changes about 1500m/s.Studies show that the density of tumor tissues will be far longer than normal structure, so the two acoustic impedance exists larger difference, namely tumor tissues has stronger acoustic reflection and scattering effect than near normal structure.The sensor at receiving transducer place is collected echo, and is formed the image contrast scattergram of different material, tissue or organ by algorithm process.On ultrasonoscopy, strong echo is reflected as Bai Ying (clear zone), weak echo or be reflected as shadow (dark space) without echo.Ultrasonic detecting technology have high specific, non-invasive, equipment cost is low and resolution than advantages of higher, be applicable to that lump is less, the clinical lower focus that is difficult for touching.
The UWB imaging technique is whether the decay according to signal echo detects and have abnormal structure to exist equally.UWB electromagnetic wave propagation characteristic is relevant with the dielectric property of tissue, the difference in dielectric constant of two media is larger, its electromagnetic volume reflection in interface place is just larger, and dielectric property is with organizing liquid content that substantial connection is arranged, studies show that, the liquid content of general tumor tissues will far above around normal structure, so the dielectric property of tumor tissues and normal structure differs greatly, so electromagnetic wave signal produces larger reflection and scattered quantum at its interface place.Receptor is collected echo, and process, imaging.The UWB detection signal is generally the burst pulse of ns level, and penetration power is strong, and positioning accuracy is high, has hypersensitivity in being detected as picture, is easy to find infantile tumour; In addition, the UWB signal energy is little, and the X-ray imaging is much smaller to the harm of human body relatively.Therefore this technology has sizable clinical meaning.
Summary of the invention
Based on the important meaning of Tumor detecting technology, for know-why and the advantage of the deficiencies in the prior art and combined echocardiography imaging and UWB imaging, the present invention proposes a kind of acoustoelectric combined analytical equipment for Tumor detecting.Consider that acoustical signal detects and the electromagnetic wave signal detection has utilized respectively acoustic characteristic and the electrology characteristic of material, and these two kinds of signals can not interfere with each other, so their transmitting terminal can be integrated in the less module, and can detect target simultaneously.The present invention launches simultaneously high-frequency ultrasonic signal and the UWB electromagnetic wave signal detects tissue, process the gray-scale map that obtains respectively about ultrasonic signal and electromagnetic wave signal through signal processing and imaging algorithm after receiving echo, at last two width of cloth gray-scale maps are carried out integrated treatment and analysis, utilize the high specific of ultra sonic imaging and the hypersensitivity of UWB electromagnetic wave imaging to carry out complementation, to obtain more detection details and to make more accurately pathological analysis.
For achieving the above object, the present invention adopts following technical scheme:
A kind of acoustoelectric combined analytical equipment for Tumor detecting comprises the signal source stimulating module, detectable signal transceiver module, data acquisition module, imaging processing module and the image association analysis module that connect in turn; Described signal source stimulating module is used for producing simultaneously one road high frequency complementary series coded pulse excitation and one road UWB complementary series coded pulse excitation; Described detectable signal transceiver module is launched high-frequency ultrasonic signal and UWB electromagnetic wave signal simultaneously to surveyed area after being subjected to the excitation of signal source forcing module; Described detectable signal transceiver module receives the echo of two kinds of signals, and the two-way echo-signal is carried out the complementary series decoding and delivered to data acquisition module; The decoded echo-signal of described data collecting module collected two-way also produces the required data of imaging after treatment, two paths of data is delivered to the imaging processing module again; The two paths of data of described imaging processing module to receiving generates about the gray-scale map of ultrasonic signal with about the gray-scale map of electromagnetic wave signal, again two width of cloth gray-scale maps delivered to the image association analysis module; Described image association analysis module carries out difference to two width of cloth figure and extracts and feature extraction, forms Eigen Structure, and makes analysis-by-synthesis.
In the above-mentioned analytical equipment, described signal source stimulating module comprises two parts: a part is made of high-frequency impulse shaper and the first complementary series encoder, produces high frequency complementary series coded pulse excitation, is used for the ultrasonic probe of excitation detectable signal transceiver module; Another part is made of UWB pulse shaper and the second complementary series encoder, the UWB pulse shaper produces Gauss's burst pulse, encoded device production burst sequence, this UWB complementary series coded pulse excitation is used for the electromagnetic antenna of excitation detectable signal transceiver module.
In the above-mentioned analytical equipment, described complementary series encoder adopts complementary sequences code as coded pulse sequence, and the activation sequence of described encoder output is comprised of two 16 complementary series A, B, and activation sequence C is by A, the B composition that is connected, complementary sequences code has autocorrelation performance.
In the above-mentioned analytical equipment, described detectable signal transceiver module comprises ultrasonic probe, electromagnetic antenna and the decoder of receiving and dispatching consubstantiality, ultrasonic probe and electromagnetic antenna are respectively after the coded pulse of high frequency complementary series and UWB complementary series coded pulse excitation, scan to surveyed area simultaneously, launch respectively high frequency ultrasound detection signal and UWB Electromagnetic Wave Detection signal, and receive echo-signal separately; Decoder carries out being sent to data acquisition module after the complementary series decoding to the two-way echo-signal.
In the above-mentioned analytical equipment, described data acquisition equipment is processed respectively the decoded echo-signal of two-way: the detection of echoes signal intensity generates normalized intensity level s; Then form data format for (wherein x and y are respectively abscissa and the vertical coordinates of scanning impact point for (x, y), two paths of data s), and deliver to the imaging processing module.
In the above-mentioned analytical equipment, described imaging processing module utilizes imaging algorithm that the two-way echo strength Value Data that receives is carried out respectively imaging processing, generation is about the gray-scale map of ultrasonic signal with about the gray-scale map of electromagnetic wave signal, and two width of cloth gray-scale maps are delivered to the image association analysis module.
In the above-mentioned analytical equipment, described image association analysis module receives two width of cloth gray-scale maps that the imaging processing module transmits, and utilizes the high specific of ultra sonic imaging and the hypersensitivity of UWB electromagnetic wave imaging to carry out complementation, and makes pathological analysis.
In the above-mentioned analytical equipment, the image association analysis module finish following work:
The first, in the UWB signal graph, extract the zone that is lower than preset gate limit value TH with ultrasonic signal figure dependency, form " acoustoelectric signal disparity map ", and be presented on separately on the display;
The second, ultrasonic signal figure and UWB signal graph are transformed on " feature space " from " coordinate-gray value space ", the comparison by Eigen Structure provides reference information Xiang the doctor; The image association analysis module at first to two width of cloth gray-scale maps extraction eigenvalue separately, forms Eigen Structure in identical feature space; Then calculate respectively the center of gravity O of two Eigen Structures
1And O
2, and calculate O
1And O
2Distance B in feature space=| O
1-O
2|; At last carry out following analysis according to the value of D:
(1) if satisfy D＞Th, then two Eigen Structure similarities are high, illustrate that the detection effect of two paths of signals is basically identical;
(2) if satisfy Tl＜D＜Th, then two Eigen Structures are similar not high, and instruction book is analyzed from UWB electromagnetic wave image may cause erroneous judgement, and prompting must be analyzed just with reference to ultrasonic signal figure and can draw more accurately conclusion thus;
(3) if satisfy D＜Tl, then two Eigen Structure similarities are very low, illustrate wherein one the tunnel to detect and may make mistakes, and the information that these two width of cloth gray-scale maps that draw provide may be unreliable, needs to consider to re-start detection, and wherein Tl and Th are the threshold values of presetting.
The analytical method of above-mentioned analytical equipment may further comprise the steps:
Step 1, in the signal source stimulating module, the output of high frequency pulse generator produces high-frequency coding pulse excitation sequence through the complementary series encoder; The output of UWB pulse shaper produces UWB coded pulse activation sequence through the complementary series encoder.Excitation signals is sent to the detectable signal transceiver module simultaneously.
After ultrasonic probe in step 2, the detectable signal transceiver module and electromagnetic antenna are encouraged, launch respectively high frequency ultrasound pulse sequence signal and UWB electromagnetic impulse sequence signal, simultaneously surveyed area is scanned.
Ultrasonic probe in step 3, the detectable signal transceiver module and electromagnetic antenna receive respectively the echo of high-frequency ultrasonic signal and the echo of UWB electromagnetic wave signal, and two-way echo-signal input decoder is decoded.
Step 4, decoded two paths of signals enter data acquisition module, and this module is processed decoded echo-signal, produce required " coordinate-intensity " data of imaging, and data are delivered to the imaging processing module through two-way.
Step 5, imaging processing module utilize imaging algorithm that the two paths of data that receives is carried out respectively imaging processing, generate about the gray-scale map of ultrasonic signal with about the gray-scale map of electromagnetic wave signal, and two width of cloth gray-scale maps are delivered to the image association analysis module.
Step 6, described image association analysis module carry out conjoint analysis to the figure of high-frequency ultrasonic signal and the UWB electromagnetic wave signal figure that the imaging processing module transmits: at first extract the zone that is lower than preset gate limit value TH with ultrasonic signal figure dependency in the UWB signal graph, form " acoustoelectric signal disparity map ", allow intuitively, fast the doctor that the tumor character is made preliminary assurance; Then ultrasonic signal figure and UWB signal graph are transformed on " feature space " from " coordinate-gray value space ", form Eigen Structure, and calculate the distance of geometric center of gravity in feature space of these two Eigen Structures, reliable with judging whether of this time making of this value checking.
The technical scheme of the present invention is integrated supersonic sounding and UWB electromagnetic wave detection has following advantage and technique effect:
1, utilize simultaneously the acoustic characteristic of material and electrology characteristic to survey, two kinds of different detectable signals of physical property are carried out integrated treatment and analysis, thereby obtain more target detail, making has more reference information when analyzing pathologic feature.
2, utilize the high specific of ultra sonic imaging to reduce the erroneous judgement situation that causes because of UWB imaging hypersensitivity, thereby improve the accuracy of pathological analysis; Utilize hypersensitivity and the pinpoint accuracy of UWB imaging to obtain the edge details abundanter than ultra sonic imaging, thereby obtain more pathological informations as analyzing foundation.
3, ultrasonic signal and electromagnetic wave signal do not interfere with each other, its transmitting terminal can be integrated in the less module, and can transmit and receive simultaneously this two kinds of detection signals, and therefore comparing with the single checkout gear of planting signal of emission, the present invention can't expend more time cost.
4, adopt the complementary series coded pulse to survey, can obtain higher signal to noise ratio.
Description of drawings
Fig. 1 is theory diagram of the present invention;
Fig. 2 a is the ultra sonic imaging sketch map of tumor;
Fig. 2 b is the UWB imaging sketch map of tumor;
Fig. 2 c is the acoustoelectric signal disparity map of tumor;
Fig. 3 is workflow diagram of the present invention;
Fig. 4 is the workflow diagram of image association analysis module;
Fig. 5 a is the figure of high-frequency ultrasonic signal Eigen Structure sketch map;
Fig. 5 b is UWB electromagnetic wave signal figure Eigen Structure sketch map.
The specific embodiment
The present invention is described in further detail below in conjunction with embodiment and accompanying drawing, but embodiments of the present invention are not limited to this.
Embodiment
As shown in Figure 1, the present invention is comprised of 5 modules: signal source stimulating module, detectable signal transceiver module, data acquisition module, imaging processing module and image association analysis module.Wherein, dotted arrow represents detectable signal in the direction of propagation of generation, transmission phase, and solid arrow represents that echo-signal is in reception, processing, the direction of propagation in imaging stage.The signal source stimulating module produces one road high frequency complementary series coded pulse excitation and one road UWB complementary series coded pulse excitation simultaneously, after the detectable signal transceiver module excited target, simultaneously to surveyed area emission high-frequency ultrasonic signal and UWB electromagnetic wave signal; The detectable signal transceiver module receives the echo of two kinds of signals, the two-way echo-signal is decoded and delivers to data acquisition module; Data acquisition module, this module is processed respectively the decoded echo-signal of two-way, produces the required data of imaging, two paths of data is delivered to the imaging processing module again; The imaging processing module utilizes imaging algorithm that the two paths of data that receives is processed respectively, generates about the gray-scale map of ultrasonic signal with about the gray-scale map of electromagnetic wave signal, and two width of cloth gray-scale maps are delivered to the image association analysis module; The image association analysis module carries out difference to two width of cloth figure and extracts and feature extraction, forms Eigen Structure, and makes analysis-by-synthesis.
Described signal source stimulating module comprises two-way excitation output.One route high-frequency impulse shaper and consist of based on the first complementary series encoder of DSP TMS320C50 produces sequence of high frequency pulses, is used for the ultrasonic probe of excitation detectable signal transceiver module; Another route UWB pulse shaper and consist of based on the second complementary series encoder of DSPTMS320C50, the UWB pulse shaper produces Gauss's burst pulse, encoded device production burst sequence, this UWB pulse train are used for the electromagnetic antenna of excitation detectable signal transceiver module.
Adopt the coded pulse energisation mode to survey herein and can obtain higher signal to noise ratio, its principle is as follows:
Suppose that the quantity of information that enters decoder is: C
i=B
iLog
2(1+S
i/ N
i), decoder is B with bandwidth
iInput signal to be demodulated into bandwidth be B
oOutput signal, its quantity of information is: C
o=B
oLog
2(1+S
o/ N
o).C is quantity of information in the formula; B is signal bandwidth; S is signal power; The N noise power; Subscript i, o represent respectively the decoder input and output.Because the input signal of decoder and output signal must have equal quantity of information, namely have: B
iLog
2(1+S
i/ N
i)=B
oLog
2(1+S
o/ N
o).Generally speaking, S/N＞＞1, then (B
i/ B
o) log
2(S
i/ N
i) ≈ log
2(S
o/ N
o), and because chnnel coding has increased redundancy to information source, therefore the signal of signal behind ratio decoder in the unit interval before the decoding has larger data volume, and B is namely arranged
i＞B
oSo, S
o/ N
o＞S
i/ N
i, so coding system can be obtained higher signal to noise ratio.
The present invention adopts complementary sequences code as coded pulse sequence.The activation sequence of described encoder output is comprised of two 16 complementary series A, B, and activation sequence C is by A, the B composition that is connected.Complementary sequences code has desirable autocorrelation performance, and good autocorrelation performance can guarantee can obtain clearly imaging after echo-signal is through decoding.
Described detectable signal transceiver module forms by the ultrasonic probe, electromagnetic antenna of transmitting-receiving consubstantiality with based on the decoder of DSPTMS320C50.Ultrasonic probe and electromagnetic antenna are respectively after the coded pulse of high frequency complementary series and UWB complementary series coded pulse excitation, scan to surveyed area simultaneously, launch respectively high frequency ultrasound detection signal and UWB Electromagnetic Wave Detection signal, and receive echo-signal separately.Because acoustical signal is different with signal of telecommunication physical property, do not interfere with each other, therefore can in same module, transmit and receive simultaneously.Decoder carries out being sent to data acquisition module after the complementary series decoding to the two-way echo-signal.
Described data acquisition module adopts the EM200 module of Huawei Company, and the decoded echo-signal of two-way is processed respectively: the detection of echoes signal intensity generates normalized intensity level s; Then form data format for (wherein x and y are respectively abscissa and the vertical coordinates of scanning impact point for (x, y), two paths of data s), and deliver to the imaging processing module.
Described imaging processing module adopts the TMS34020 chip of TI company, utilize imaging algorithm that the two-way echo strength Value Data that receives is carried out respectively imaging processing, generation is about the gray-scale map of ultrasonic signal with about the gray-scale map of electromagnetic wave signal, and two width of cloth gray-scale maps are delivered to the image association analysis module.
Described image association analysis module is realized that by computer software two width of cloth gray-scale maps that the imaging processing module is transmitted carry out analysis-by-synthesis, detects more accurately pathological analysis result to draw than single signal.The meaning of conjoint analysis is to utilize the high specific of ultra sonic imaging and the hypersensitivity of UWB electromagnetic wave imaging to carry out complementation, to obtain more detection details and to make more accurately pathological analysis:
At first, ultrasonic signal figure can remedy at the accuracy of judgement degree deficiency of UWB signal graph: the UWB imaging has hypersensitivity, the erroneous judgement situation occurs easily, might draw positive findings to cyst or most of calcification.For example, the UWB imaging of cyst might be that the real property of white is block, and is closely similar with tumor imaging, produces easily erroneous judgement.And hot spot or light belt can appear in the ultrasonic image of cyst, be easy to distinguish with tumor imaging.Therefore, the high specific of ultra sonic imaging can be made accurate judgement to cyst or calcification, thereby be reduced to a certain extent the probability of miscarriage of justice of UWB electromagnetic wave signal figure.
In addition, the UWB signal graph also can remedy the deficiency of ultrasonic signal figure in detail: generally speaking, the fibroid peplos of intact is arranged around the carcinoid lump, its image boundary is more clearly; And the periphery of malignant tumor lump does not have peplos, or peplos is incomplete, presents ambiguous border at the traditional medicine image, and generally there is different local edges in the malignant tumor image of different pathological character.Therefore, accurately catch the pathologic feature that borderline tumor helps to analyze tumor.The high accuracy that UWB detects can obtain more edge details than ultrasound detection, and can also detect the diffusion trend of cancerous cell, as shown in Figure 2: Fig. 2 a is the ultra sonic imaging sketch map of tumor, and white portion is detected tumor region, its edge is dim shadow region, and is smudgy; The ash color part is other normal structures; Fig. 2 b is the UWB imaging sketch map of tumor, and white portion is detected tumor region equally, and different is that the shadow region at its edge is more clear than the edge among the ultrasonic figure, bright, easier observation.And can find out that cancerous cell just spreads toward the upper right side.In addition, the hypersensitivity of UWB imaging makes it than the easier early-stage cancer that detects of ultra sonic imaging.
This shows that ultrasonic signal figure and UWB electromagnetic wave signal figure can be complementary not enough, comprehensive two figure analyze just can make accurately and judge.
In order to make things convenient for the doctor to analyze and to make more accurately and judge that described image association analysis module carries out further Combined Treatment to ultrasonic signal figure and the UWB signal graph that the imaging processing module transmits.The image association analysis module mainly contains two work:
First, in the UWB signal graph, extract the zone that is lower than preset gate limit value TH with ultrasonic signal figure dependency, form " acoustoelectric signal disparity map ", and be presented on separately on the display, shown in Fig. 2 c: what this figure reflected mainly is the edge configuration of tumor and the spread condition of cancerous cell, can allow intuitively, fast the doctor that the tumor character is made preliminary analysis and judgement.
The second, ultrasonic signal figure and UWB signal graph are transformed on " feature space " from " coordinate-gray value space ", the comparison by Eigen Structure provides more reference information Xiang the doctor.The image association analysis module at first to two width of cloth gray-scale maps extraction eigenvalue CH1, CH2......CHh separately, forms Eigen Structure in identical feature space; Then calculate respectively the center of gravity O of two Eigen Structures
1And O
2, and calculate O
1And O
2Distance B in feature space=| O
1-O
2|; At last according to judging whether reliably that the value checking of D is made before this.Specifically carry out following analysis:
(1) if satisfy D＞Th, then two Eigen Structure similarities are high, illustrate that the detection effect of two paths of signals is basically identical, and the analysis of carrying out on this basis will have higher accuracy.
(2) if satisfy Tl＜D＜Th, then two Eigen Structures are similar not high, and instruction book is analyzed from UWB electromagnetic wave image may cause erroneous judgement, point out thus the doctor to analyze just with reference to ultrasonic signal figure and can draw more accurately conclusion.
(3) if satisfy D＜Tl, then two Eigen Structure similarities are very low, illustrate wherein one the tunnel to detect and may make mistakes, and the information that these two width of cloth gray-scale maps that draw provide may be unreliable, and the doctor need consider to re-start detection.(wherein Tl and Th are the threshold values of presetting.)
In sum, described image association analysis module at first forms " acoustoelectric signal disparity map ", allows intuitively, fast the doctor that the tumor character is made preliminary assurance; Then the Eigen Structure on its feature space compares to ultrasonic signal figure and UWB signal graph, and judging whether that checking is this time made is reliable.
Adopt the coded pulse energisation mode to survey and to obtain higher signal to noise ratio.For realizing this function, present embodiment adopts complementary sequences code as coded pulse sequence.The activation sequence of described encoder output is comprised of two 16 complementary series A, B, A={1 wherein, 1,1 ,-1 ,-1 ,-1,1 ,-1 ,-1 ,-1,-1,1 ,-1 ,-1,1 ,-1}, B={1,1,1 ,-1 ,-1,-1,1 ,-1,1,1,1 ,-1,1,1 ,-1,1}, then activation sequence is C={A, B}={1,1,1 ,-1 ,-1 ,-1,1 ,-1 ,-1 ,-1,-1,1 ,-1 ,-1,1 ,-1,1,1,1 ,-1 ,-1,-1,1 ,-1,1,1,1 ,-1,1,1 ,-1,1}.Complementary sequences code has desirable autocorrelation performance, and good autocorrelation performance can guarantee can obtain clearly imaging after echo-signal is through decoding.
Described detectable signal transceiver module is comprised of ultrasonic probe, electromagnetic antenna and the decoder of transmitting-receiving consubstantiality.Ultrasonic probe and electromagnetic antenna are respectively after the coded pulse of high frequency complementary series and UWB complementary series coded pulse excitation, scan to surveyed area simultaneously, launch respectively high frequency ultrasound detection signal and UWB Electromagnetic Wave Detection signal, and receive echo-signal separately.Because acoustical signal is different with signal of telecommunication physical property, do not interfere with each other, therefore can in same module, transmit and receive simultaneously.Decoder carries out being sent to data acquisition module after the complementary series decoding to the two-way echo-signal.
Described data acquisition equipment is processed respectively the decoded echo-signal of two-way: the detection of echoes signal intensity generates normalized intensity level s; Then be data format that ((x, y), two paths of data s) are delivered to the imaging processing module.
Described imaging processing module utilizes imaging algorithm that the two paths of data that receives is carried out respectively imaging processing, generates about the gray-scale map of ultrasonic signal with about the gray-scale map of electromagnetic wave signal, and two width of cloth gray-scale maps are delivered to the image association analysis module.
As shown in Figure 3, present embodiment adopts following job step:
Step 1, in the signal source stimulating module, the output of high frequency pulse generator produces high-frequency coding pulse excitation sequence through complementary series encoder 1; The output of UWB pulse shaper produces UWB coded pulse activation sequence through complementary series encoder 2.Excitation signals is sent to the detectable signal transceiver module simultaneously.
After ultrasonic probe in step 2, the detectable signal transceiver module and electromagnetic antenna are encouraged, launch respectively high frequency ultrasound pulse sequence signal and UWB electromagnetic impulse sequence signal, simultaneously surveyed area is scanned.
Ultrasonic probe in step 3, the detectable signal transceiver module and electromagnetic antenna receive respectively the echo of high-frequency ultrasonic signal and the echo of UWB electromagnetic wave signal, and two-way echo-signal input decoder is decoded.
Step 4, decoded two paths of signals enter data acquisition module, and this module is processed decoded echo-signal, produce required " coordinate-intensity " data of imaging, and data are delivered to the imaging processing module through two-way.
Step 5, imaging processing module utilize imaging algorithm that the two paths of data that receives is carried out respectively imaging processing, generate about the gray-scale map of ultrasonic signal with about the gray-scale map of electromagnetic wave signal, and two width of cloth gray-scale maps are delivered to the image association analysis module.
Step 6, described image association analysis module carry out conjoint analysis to the figure of high-frequency ultrasonic signal and the UWB electromagnetic wave signal figure that the imaging processing module transmits: at first extract the zone that is lower than preset gate limit value TH with ultrasonic signal figure dependency in the UWB signal graph, form " acoustoelectric signal disparity map ", allow intuitively, fast the doctor that the tumor character is made preliminary assurance; Then ultrasonic signal figure and UWB signal graph are transformed on " feature space " from " coordinate-gray value space ", form Eigen Structure, and calculate the distance of geometric center of gravity in feature space of these two Eigen Structures, reliable with judging whether of this time making of this value checking.
As shown in Figure 4, described image association analysis module adopts following job step:
Step 1, in the UWB signal graph, extract the zone that is lower than preset gate limit value TH with ultrasonic signal figure dependency, form " acoustoelectric signal disparity map ", tentatively hold the tumor character.
Step 2, respectively high-frequency ultrasonic signal figure and UWB electromagnetic wave signal figure are carried out feature extraction, calculate its eigenvalue separately: CH1, CH2......CHh.
Step 3, basis eigenvalue generating feature pattern on identical feature space separately (suppose to have 6 features) shown in Fig. 5 a and Fig. 5 b.
The geometric center of gravity O of step 4, two Eigen Structures of calculating
1And O
2, and calculate O
1And O
2Distance B in feature space.
Step 5, be further analyzed according to the value of D:
(1) if satisfy D＞Th, then two Eigen Structure similarities are high, illustrate that the detection effect of two paths of signals is basically identical, and the analysis of carrying out on this basis will have higher accuracy.
(2) if satisfy Tl＜D＜Th, then two Eigen Structures are similar not high, and instruction book is analyzed from UWB electromagnetic wave image may cause erroneous judgement, point out thus the doctor to analyze just with reference to ultrasonic signal figure and can draw more accurately conclusion.
(3) if satisfy D＜Tl, then two Eigen Structure similarities are very low, illustrate wherein one the tunnel to detect and may make mistakes, and the information that these two width of cloth gray-scale maps that draw provide may be unreliable, and the doctor need consider to re-start detection.(wherein Tl and Th are the threshold values of presetting.)
The technical scheme of the present invention is integrated ultrasonic imaging and UWB electromagnetic wave imaging is carried out feature extraction to the echo of two kinds of detectable signals, forms Eigen Structure, and carries out conjoint analysis.Characteristics of the present invention are: utilize two kinds of different signals of physical property to survey, can obtain more target detail, for pathological analysis provides more reference information; Utilize the high specific of ultra sonic imaging and hypersensitivity, the pinpoint accuracy of UWB imaging to carry out complementation, thereby make the pathological analysis result more accurate; Supersonic sounding and electromagnetic wave detection do not interfere with each other, and can carry out simultaneously, thereby save the time cost that detects operation, and the transmitting terminal of two kinds of signals can be integrated in the less module; Adopt coded pulse to survey, can obtain higher signal to noise ratio.Above-described embodiment is the better embodiment of the present invention; but embodiments of the present invention are not restricted to the described embodiments; other any do not deviate from change, the modification done under spirit of the present invention and the principle, substitutes, combination, simplify; all should be the substitute mode of equivalence, be included within protection scope of the present invention.
Claims (8)
1. an acoustoelectric combined analytical equipment that is used for Tumor detecting is characterized in that comprising the signal source stimulating module, detectable signal transceiver module, data acquisition module, imaging processing module and the image association analysis module that connect in turn;
Described signal source stimulating module is used for producing simultaneously one road high frequency complementary series coded pulse excitation and one road UWB complementary series coded pulse excitation; Described detectable signal transceiver module is launched high-frequency ultrasonic signal and UWB electromagnetic wave signal simultaneously to surveyed area after being subjected to the excitation of signal source forcing module; Described detectable signal transceiver module receives the echo of two kinds of signals, and the two-way echo-signal is carried out the complementary series decoding and delivered to data acquisition module; The decoded echo-signal of described data collecting module collected two-way also produces the required data of imaging after treatment, two paths of data is delivered to the imaging processing module again; The two paths of data of described imaging processing module to receiving generates about the gray-scale map of ultrasonic signal with about the gray-scale map of electromagnetic wave signal, again two width of cloth gray-scale maps delivered to the image association analysis module; Described image association analysis module carries out difference to two width of cloth figure and extracts and feature extraction, forms Eigen Structure, and makes analysis-by-synthesis.
2. analytical equipment according to claim 1, it is characterized in that described signal source stimulating module comprises two parts: a part is made of high-frequency impulse shaper and the first complementary series encoder, produce high frequency complementary series coded pulse excitation, be used for the ultrasonic probe of excitation detectable signal transceiver module;
Another part is made of UWB pulse shaper and the second complementary series encoder, the UWB pulse shaper produces Gauss's burst pulse, be UWB complementary series coded pulse excitation through the second complementary series encoder production burst sequence, this UWB complementary series coded pulse excitation is used for the electromagnetic antenna of excitation detectable signal transceiver module.
3. analytical equipment according to claim 2 is characterized in that described complementary series encoder adopts complementary sequences code as coded pulse sequence, and the activation sequence of described complementary series encoder output is by two 16 complementary series
A,
BForm activation sequence
CBy
A, BThe composition that is connected, complementary sequences code has autocorrelation performance.
4. analytical equipment according to claim 1, it is characterized in that described detectable signal transceiver module comprises ultrasonic probe, electromagnetic antenna and the decoder of receiving and dispatching consubstantiality, ultrasonic probe through high frequency complementary series coded pulse excitation, electromagnetic antenna after UWB complementary series coded pulse excitation, ultrasonic probe and electromagnetic antenna scan to surveyed area simultaneously, launch respectively high frequency ultrasound detection signal and UWB Electromagnetic Wave Detection signal, and receive echo-signal separately; Decoder carries out being sent to data acquisition module after the complementary series decoding to the two-way echo-signal.
5. analytical equipment according to claim 1, it is characterized in that described data acquisition equipment processes respectively the decoded echo-signal of two-way: the detection of echoes signal intensity generates normalized intensity level
sThen form data format for ((
X, y)
, s) two paths of data, and deliver to the imaging processing module, wherein
xWith
yRespectively abscissa and the vertical coordinate of scanning impact point.
6. analytical equipment according to claim 5, it is characterized in that described imaging processing module utilizes imaging algorithm that the two-way echo strength Value Data that receives is carried out respectively imaging processing, generate the gray-scale map of ultrasonic signal and the gray-scale map of electromagnetic wave signal, and two width of cloth gray-scale maps are delivered to the image association analysis module.
7. analytical equipment according to claim 6, it is characterized in that described image association analysis module receives two width of cloth gray-scale maps that the imaging processing module transmits, utilize the high specific of ultra sonic imaging and the hypersensitivity of UWB electromagnetic wave imaging to carry out complementation, and make pathological analysis.
8. analytical equipment according to claim 7 is characterized in that the following work of finishing of image association analysis module:
The first, the gray-scale map dependency that extracts in the gray-scale map of electromagnetic wave signal with ultrasonic signal is lower than the preset gate limit value
THThe zone, form " acoustoelectric signal disparity map ", and be presented on separately on the display;
The second, the gray-scale map of ultrasonic signal and the gray-scale map of electromagnetic wave signal are transformed on " feature space " from " coordinate-gray value space ", the comparison by Eigen Structure provides reference information Xiang the doctor; The image association analysis module at first to two width of cloth gray-scale maps extraction eigenvalue separately, forms Eigen Structure in identical feature space; Then calculate respectively the center of gravity of two Eigen Structures
With
, and calculate
With
Distance in feature space
Last basis
DValue carry out following analysis:
(1) if satisfies
, then two Eigen Structure similarities are high, illustrate that the detection effect of two paths of signals is basically identical;
(2) if satisfy
, then two Eigen Structures are similar not high, and instruction book is analyzed from UWB electromagnetic wave image may cause erroneous judgement, and prompting must be analyzed just with reference to ultrasonic signal figure and can draw more accurately conclusion thus;
(3) if satisfy
, then two Eigen Structure similarities are very low, illustrate wherein one the tunnel to detect and may make mistakes, and the information that these two width of cloth gray-scale maps that draw provide may be unreliable, needs to consider to re-start detection, wherein
With
It is the threshold value of presetting.
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