CN102258802A - Novel multifunctional hemostatic dressing - Google Patents
Novel multifunctional hemostatic dressing Download PDFInfo
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- CN102258802A CN102258802A CN2010101854701A CN201010185470A CN102258802A CN 102258802 A CN102258802 A CN 102258802A CN 2010101854701 A CN2010101854701 A CN 2010101854701A CN 201010185470 A CN201010185470 A CN 201010185470A CN 102258802 A CN102258802 A CN 102258802A
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Abstract
The invention relates to a novel multifunctional hemostatic dressing, which is characterized in that the hemostatic dressing provided by the invention is prepared by the following method: 1, preparation of different deacetylation degrees of chitosan; 2, preparation of modified and reconstructed collagen: controlling the chemical modification degree, molecular integrity, molecular weight and concentration of the collagen; 3, purification of chrysophanol: acquiring effective hemostatic substances in the traditional Chinese medicine rheum officinale and carrying out quantitative study; 4, carrying out organic composite on the three components of collagen, chitosan and chrysophanol, ensuring the flexibility of a freeze-drying pad composite sponge as well as the sealing performance, adhesiveness and integrity of an outer membrane. The novel multifunctional hemostatic dressing provided by the invention can be used to rapidly stop bleeding, resist inflammation, easing pain and promote healing, and can be used for military war injury haemostasis and restoration and general hemostatic emergency treatment for civil use.
Description
Technical field
The present invention relates to the multifunctional hemostatic dressing of a kind of energy quick-acting haemostatic powder, anti-inflammatory and antalgic, promotion healing.
Technical background
Wound hemorrhage is one of important disease of harm humans health and lives safety, and no matter War And Peace period, unmanageable massive hemorrhage is to cause wounded's main causes of death.The war wound that causes owing to losing blood in the war is cut personnel larger proportion, and about according to statistics 50% person killed in action is before delivering to the first aid station, because of severe loss of blood death in several minutes.Injuredly in the peacetime various unexpected incidents hemorrhage also very see more.It is exactly the typical case that China's vehicle accident and the number of casualties are continuous ascendant trend.The wound severe loss of blood makes wounded's pain, stupor, shock even death, and hemostasis becomes the important step of war wound and sudden accident first aid.
The purpose of quick-acting haemostatic powder is to win therapeutic time and the acquisition good prognosis to wounded body.Traditional wrapping hemostasis can cause wrapping up necrosis and the dysfunction of position with lower limb body, advocates and does not abuse tourniquet.And the wrapping hemostasis can't press the massive hemorrhage of pricking the position to seem powerless to those.Therefore seek novel hemostatic material and apparatus is the wound hemostasis urgent problem, be subjected to the great attention of countries in the world medical science and military medicine.Along with to the going deep into of researching wound healing, the purpose of using dressing is far from for the flap coverage hemostasis, analgesia and promote healing to become the certainty of hemostatic material development.Existing hemostatic material is confined to simple hemostasis more, and is also fewer for the research and development of aspects such as analgesia, infection, promotion healing.
Chitosan, collagen protein and Chinese herb rhubarb are to have different structure characteristics, well behaved hemorrhage, discover that they have complementation and cooperative effect, have blood coagulation enhancing effect to heparinized blood.The Multifunction bleeding-stopping dressing be exactly recombination chitosan, collagen and Chinese herb rhubarb phenol be one, can quick-acting haemostatic powder, anti-inflammatory and antalgic and promote the novel hemostatic material of healing.
The Multifunction bleeding-stopping dressing has been started the innovative thinking that develops into synthtic price index solutions such as quick-acting haemostatic powder, antalgic and inflammation relieving, promotion healing from simple wound hemostasis.Solved synthtic price index such as using hemostasis in the insurmountable sudden accident emergency treatment of traditional method, infection, alleviating pain clinically, make war or peacetime wound hemorrhage not only obtain rapidly effectively control but also the analgesic effect is infected in performance, improve the wounded's quality of life.
This multifunctional hemostatic dressing also has easy to carry, advantages such as easy preservation, and not only for the first-aid personnel provides effective means, and wounded body only just can self rescue otherwise lose consciousness.Its scope of application is very wide, the soldier on the battlefield, the personnel of dangerous work post, even common laboratory, hospital, medical station, family emergency all can be equipped with this pad binder.Solve the emergency treatment hemostasis problem of the insurmountable sudden accident of traditional method, be adapted to the treatment strategy of the war wound self rescue under peacetime and the new military change.
Summary of the invention
The object of the present invention is to provide a kind of on the basis of at present simple hemostatic material, with collagen, chitosan, chrysophanol compound be one, can quick-acting haemostatic powder, the Multifunction bleeding-stopping dressing that heals of antalgic and inflammation relieving and promoting.Satisfy wartime and hemostasis first aid needs at ordinary times, improve the wounded's quality of life,, improve prognosis for the wounded win therapeutic time.
For realizing that the technical scheme that above-mentioned purpose of the present invention adopts is such, promptly a kind of Multifunction bleeding-stopping dressing can quick-acting haemostatic powder, antalgic and inflammation relieving and promote healing, it is characterized in that: adopts following method to prepare:
1, the preparation of different deacetylation chitosans;
2, modify the proteic preparation of reconstructed collagen: chemical modification degree, molecule integrity, molecular weight and the concentration of control collagen protein;
3, chrysophanol purification; Obtain hemostatic active substance in the Chinese herb rhubarb, and quantitative study;
4, collagen, chitosan and chrysophanol three are carried out organic compound, guarantee lyophilizing pad composite sponge pliability, adventitia has sealing, adhesiveness and integrity.
In above-mentioned preparation method, chitosan described in the step 1 adopts the method for taking off acetyl to make; Collagen protein is modified reconstructed collagen albumen by controlling its chemical modification degree, molecule integrity, molecular weight and concentration in step 2; Chrysophanol in the step 3 extracts in the middle of Chinese herb rhubarb; Step 4 is that collagen and chitosan are cooperated the formation molecular link by a certain percentage, carries out crosslinked, lyophilizing, controlling slow release adding chrysophanol.
The subject matter that the present invention solves is the required Multifunction bleeding-stopping dressing of wartime and first aid at ordinary times, can quick-acting haemostatic powder, antalgic and inflammation relieving and promote to heal, compared with prior art have following advantage:
1. material property complementation and collaborative characteristic.Chitosan, collagen protein and Chinese herb rhubarb are to have the different structure characteristics, and they have complementation and cooperative effect, and heparinized blood is had blood coagulation enhancing effect.Chitosan is a kind of degradable polysaccharide polymer for preparing with the shell of shrimp Eriocheir sinensis class animal, the character that has control over bleeding, antibacterial/antibiotic property, biocompatibility, promotion wound healing and be easy to form gel has been given its superperformance as bleeding-stopping dressing or hemorrhage.Chemical modification collagen derives from the extracellular matrix structural protein, when spongiform chemical modification collagen contacts with blood, can utilize the capillarity of its sponge structure, adsorb blood rapidly, cause platelet aggregation, platelet destruction, activation and release thrombin, thus promote coagulation process.The Chinese medicine of Radix Et Rhizoma Rhei " being the gas medicine, is again the blood medicine, hemostasis and do not stay the stasis of blood, particularly panacea ", along with to the deepening continuously of Radix Et Rhizoma Rhei hemostasis pharmacological research, Chinese herb rhubarb has the hemagglutinative function of promotion and has obtained remarkable break-throughs in clinical research with using.
2. the multi-functional characteristic of product.Multi-functional quick-acting haemostatic powder first aid pad is by chitosan, modification reconstructed collagen and the compound preparation of chrysophanol of different deacetylations.Fully hemostasis in the research emergency care of trauma, infection, Theory of Pain Mechanism are effect collection such as quick-acting haemostatic powder, infection control and alleviating pains one, and exploitation possesses the multifunctional product of these characteristics.
3. carry, preserve and use all very convenient.This multi-functional quick-acting haemostatic powder first aid pad product is not only for the first-aid personnel provides effective means, and wounded body only just can self rescue otherwise lose consciousness.Be adapted to accident and first aid of battle field especially.
4. have independent intellectual property right.Quick-acting haemostatic powder, antibacterial, the multi-functional quick-acting haemostatic powder first aid in analgesic pad product have independent intellectual property right, will indicate that China is through with and does not have a kind of like this situation of emergency aid articles for many years, and the advanced product that possesses skills will match in excellence or beauty with external like product.
5. propose the notion of multi-functional comprehensive first aid pad first and give its content.At present both at home and abroad emergency equipment concentrates on mostly and reduces a hemorrhage aspect, and rescues the scene in accident, not only exists hemorrhage but also can occur infecting, and handles all very difficult again so that deliver to hospital.And we consider the information summary at scene and are analyzed, and have proposed the new concept of multi-functional comprehensive processing.
6. take the lead at home developing this product and putting on market.Do not have this series products at present both at home and abroad,, novelty is not only arranged but also great vitality is arranged so under new theory instructs, employ new technology with the launch products of its research and development.
The specific embodiment:
Below in conjunction with embodiment content of the present invention is described further.
1, difference is taken off the preparation of acetyl shell degree polysaccharide; Chitin is after high alkali liquid is handled, and acetamido can remove in partial hydrolysis in the molecule, and acetyl group more than half removes in molecule just becomes chitosan.Because acetamido has replaced hydroxyl on the chitin monomer C2 position, it is insoluble to diluted acid diluted alkaline and organic solvent, its character like fibrous element. when just being removed, acetyl group more than half can in acid, dissolve.When chitosan is dissolved in the acid solution, the free amino on the monomer molecule is (NH2) protonated and positively charged (NH3+) becomes cationic polymer, can adsorb some electronegative materials.This experiment is just carried out coagulant to the chitosan of different deacetylations in the bigger chitosan of molecular weight (9.3 * 105～9.8 * 105) and bacteriostatic is further studied, and provides theoretical foundation for making up the multifunctional hemostatic dressing that collagen, chitosan and chrysophanol be composited
2, modify the proteic preparation of reconstructed collagen: chemical modification degree, molecule integrity, molecular weight and the concentration of control collagen protein; Collagen protein type and content: type i collagen, noncollagen protein impurity content＜1%.Melt temperature Tp:50 ℃-80 ℃.Total metals:＜10mg/kg.Sugar content:＜1.0g/kg.Fat content:＜0.1%.Ash:＜1.0%.PH value: 7.0 ± 0.4.Pyrogen: should meet the qualification determination requirement of 2000 editions two appendix pyrogen tests of Pharmacopoeia of People's Republic of China.Haemolysis: hemolysis rate≤5%.Cytotoxicity: cytotoxicity I-O level.
3, chrysophanol purification; Obtain hemostatic active substance in the Chinese herb rhubarb, and quantitative study; Earlier general anthraquinone glycosides in the Radix Et Rhizoma Rhei is hydrolyzed into aglycon with dilution heat of sulfuric acid, reusable heat chloroform extraction aglycon is removed chrysophanic acid, emodin, aloe-emodin in the chloroform solution with alkali liquor, and separates chrysophanol and emodin with column chromatography, through ethanol repeated multiple times recrystallization, get highly purified chrysophanol; Adopt the wherein content of chrysophanol of high effective liquid chromatography for measuring.Make chrysophanol purity reach more than 98%.
4, carry out collagen, chitosan and chrysophanol three organic compound, guarantee lyophilizing pad composite sponge pliability, adventitia has sealing, adhesiveness and integrity: study the influence of the proportioning of different collagens and chitosan to haemostatic effect, and pass through the compound chrysophanol slow release of animal experiment study afterwards to anti-inflammatory and antalgic, agglutinant effect.
Describe for example below, but application of the present invention not only is this.
The preparation of embodiment 1. Multifunction bleeding-stopping dressings is prepared corresponding chitosan, collagen and chrysophanol by above-mentioned steps (1) (2) (3) method, and (4) carry out the compound of different proportionings set by step.
After the collagen that obtains, chitosan, the crosslinked lyophilizing of chrysophanol composite, cover the hemorrhage mice position of limb injury, observe its haemostatic effect, find stopped bleeding after 1 minute.And use collagen to cover the mice bleeding part of same damage merely as hemostatic material, stopped bleeding after 5 minutes.The simple chitosan that uses covers the mice bleeding part of same damage, stopped bleeding after 4 minutes as hemostatic material.Utilize the compound material of collagen and chitosan to cover the mice bleeding part of same damage, stopped bleeding after 2 minutes.
The preparation of embodiment 2. Multifunction bleeding-stopping dressings is prepared corresponding chitosan, collagen and chrysophanol by above-mentioned steps (1) (2) (3) method, and (4) carry out the compound of different proportionings set by step.
After the collagen that obtains, chitosan, the crosslinked lyophilizing of chrysophanol composite, adopt same condition of culture to cultivate staphylococcus and anaerobe.The growth of antibacterial is obviously suppressed after the composite overnight incubation of observation discovery collagen, chitosan and chrysophanol, and bacterial growth is vigorous on the simple collagen material.Bacterial growth quantity is lower than the collagen group and is higher than the composite group of collagen, chitosan and chrysophanol on the simple chitosan material.Use bacterial growth quantity basically identical on bacterial growth quantity on collagen and the compound material of chitosan and the simple chitosan material.
The preparation of embodiment 3. Multifunction bleeding-stopping dressings is prepared corresponding chitosan, collagen and chrysophanol by above-mentioned steps (1) (2) (3) method, and (4) carry out the compound of different proportionings set by step.
After the collagen that obtains, chitosan, the crosslinked lyophilizing of chrysophanol composite, cover the hemorrhage mice position of limb injury, it is very fast active to observe mice, and beginning is free movable.And use the group of collagen-based materials and chitosan material merely, and the mice activity is restricted, and illustrates that the hemostatic material that collagen, chitosan and chrysophanol are composited not only can stop blooding rapidly, can also alleviating pain, recover the mobility of mice.
The preparation of embodiment 4. Multifunction bleeding-stopping dressings is prepared corresponding chitosan, collagen and chrysophanol by above-mentioned steps (1) (2) (3) method, and (4) carry out the compound of different proportionings set by step.
After the collagen that obtains, chitosan, the crosslinked lyophilizing of chrysophanol composite, cover the hemorrhage mice position of limb injury, observe that wound heals substantially after 1 day.And mice wound healing substantially after 3 days of using collagen merely, using chitosan and use collagen and chitosan composite to cover merely.Illustrate that the hemostatic material that collagen, chitosan and chrysophanol are composited not only can stop blooding rapidly, can also promote the healing of wound.
Claims (5)
- One kind can quick-acting haemostatic powder, antalgic and inflammation relieving and promote the Multifunction bleeding-stopping dressing of healing,, it is characterized in that: adopts following method to prepare:(1), the preparation of different deacetylation chitosans;(2), modify the proteic preparation of reconstructed collagen: chemical modification degree, molecule integrity, molecular weight and the concentration of control collagen protein;(3), chrysophanol purification; Obtain hemostatic active substance in the Chinese herb rhubarb, and quantitative study;(4), collagen, chitosan and chrysophanol three are carried out organic compound, guarantee lyophilizing pad composite sponge pliability, adventitia has sealing, adhesiveness and integrity.
- 2. Multifunction bleeding-stopping dressing according to claim 1; it is characterized in that: at the chitin described in the step (1) of its preparation method after high alkali liquid is handled; acetamido can remove in partial hydrolysis in the molecule; acetyl group more than half removes in molecule just becomes chitosan; because acetamido has replaced hydroxyl on the chitin monomer C2 position; it is insoluble to diluted acid diluted alkaline and organic solvent, its character like fibrous element.When just being removed, acetyl group more than half can in acid, dissolve; When chitosan is dissolved in the acid solution, the free amino on the monomer molecule is (NH2) protonated and positively charged (NH3+) becomes cationic polymer, can adsorb some electronegative materials.
- 3. Multifunction bleeding-stopping dressing according to claim 1 is characterized in that: by chemical modification degree, molecule integrity, molecular weight and the concentration of preparation method step (2) control collagen protein; Collagen protein type and content: type i collagen, noncollagen protein impurity content＜1%. Melt temperature Tp:50 ℃-80 ℃; Total metals:＜10mg/kg; Sugar content:＜1.0g/kg; Fat content:＜0.1%. Ash:＜1.0%. PH value: 7.0 ± 0.4; Pyrogen: should meet the qualification determination requirement of 2000 editions two appendix pyrogen tests of Pharmacopoeia of People's Republic of China; Haemolysis: hemolysis rate≤5%; Cytotoxicity: cytotoxicity I-O level.
- 4. Multifunction bleeding-stopping dressing according to claim 1, it is characterized in that: its preparation methods steps (3) is hydrolyzed into aglycon with dilution heat of sulfuric acid with general anthraquinone glycosides in the Radix Et Rhizoma Rhei earlier, reusable heat chloroform extraction aglycon, with alkali liquor chrysophanic acid, emodin, aloe-emodin in the chloroform solution are removed, and separate chrysophanol and emodin with column chromatography, through ethanol repeated multiple times recrystallization, get highly purified chrysophanol; Adopt the wherein content of chrysophanol of high effective liquid chromatography for measuring, chrysophanol purity is reached more than 98%.
- 5. Multifunction bleeding-stopping dressing according to claim 1, it is characterized in that: its preparation methods steps (4) is carried out collagen, chitosan and chrysophanol three organic compound, guarantee lyophilizing pad composite sponge pliability, adventitia has sealing, adhesiveness and integrity: study the influence of the proportioning of different collagens and chitosan to haemostatic effect, and pass through the compound chrysophanol slow release of animal experiment study afterwards to anti-inflammatory and antalgic, agglutinant effect.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201010185470.1A CN102258802B (en) | 2010-05-28 | 2010-05-28 | A kind of Novel multifunctional hemostatic dressing |
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| CN201010185470.1A CN102258802B (en) | 2010-05-28 | 2010-05-28 | A kind of Novel multifunctional hemostatic dressing |
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| CN102258802B CN102258802B (en) | 2016-01-27 |
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Cited By (5)
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| CN103007337A (en) * | 2012-12-31 | 2013-04-03 | 凌峰 | Polymer dressing and dressing patch |
| CN104043147A (en) * | 2014-06-25 | 2014-09-17 | 陈文灵 | Sponge for sucking blood in anesthesia department and preparation method of sponge |
| CN106491568A (en) * | 2016-11-09 | 2017-03-15 | 山东百玛海洋生物科技有限公司 | A kind of marine organisms spray film for treating skin injury and infection and preparation method thereof |
| CN109303930A (en) * | 2018-09-27 | 2019-02-05 | 湖南然元医用高科技蛋白线有限公司 | A kind of Medical absorbable antiseptic dressing and preparation method thereof |
| CN111588902A (en) * | 2020-05-25 | 2020-08-28 | 医工瑞思(福建)工程研究中心有限公司 | Large-area wound first-aid dressing and preparation method thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103007337A (en) * | 2012-12-31 | 2013-04-03 | 凌峰 | Polymer dressing and dressing patch |
| CN104043147A (en) * | 2014-06-25 | 2014-09-17 | 陈文灵 | Sponge for sucking blood in anesthesia department and preparation method of sponge |
| CN106491568A (en) * | 2016-11-09 | 2017-03-15 | 山东百玛海洋生物科技有限公司 | A kind of marine organisms spray film for treating skin injury and infection and preparation method thereof |
| CN109303930A (en) * | 2018-09-27 | 2019-02-05 | 湖南然元医用高科技蛋白线有限公司 | A kind of Medical absorbable antiseptic dressing and preparation method thereof |
| CN111588902A (en) * | 2020-05-25 | 2020-08-28 | 医工瑞思(福建)工程研究中心有限公司 | Large-area wound first-aid dressing and preparation method thereof |
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| CN102258802B (en) | 2016-01-27 |
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Effective date of registration: 20201023 Address after: Chongqing city Shapingba street 400038 gaotanyan No. 30 Patentee after: ARMY MEDICAL University Address before: Chongqing city Shapingba street 400038 gaotanyan No. 30 Patentee before: Zhu Chuhong |