CN102258680A - Chinese medicinal composition for reliving physical fatigue and preparation method and use thereof - Google Patents
Chinese medicinal composition for reliving physical fatigue and preparation method and use thereof Download PDFInfo
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Abstract
The invention discloses a Chinese medicinal composition for relieving physical fatigue. The invention adopts a technical scheme that the active components of the Chinese medicinal composition are prepared from the following raw materials in part by weight: 30 to 50 parts of rhodiola rosea, 20 to 40 parts of papaya, 20 to 30 parts of poria cocos, and 10 to 20 parts of dwarf lilyturf root. The invention provides a corresponding preparation method. The medicinal composition has the effect of relieving physical fatigue.
Description
Technical field
The present invention relates to the Chinese medicine preparation technical field, be specifically related to Chinese medicine composition of a kind of alleviating physical fatigue and its production and application.
Background technology
At present, along with the quickening of work rhythm of life, it is tired that people can feel often.For allaying tiredness, can adopt usually have tea, drink coffee or eat caked sugar, method such as chew gum refreshes oneself, but these methods exist health care poor, act on singlely, and have tea, drink coffee and also have the inconvenient problem of carrying.Clinical practice is a lot of in the medicine and the tonic of alleviating physical fatigue, but these kind toxic and side effects are bigger, and are inconvenient to take, or not through the pharmacology checking, up to now, people are seeking a kind of Chinese medicine of making the alleviating physical fatigue of simple, taking convenience.
Summary of the invention
Goal of the invention: in order to address the above problem, but the object of the present invention is to provide a kind of Chinese medicine preparation of alleviating physical fatigue.
Technical scheme: the objective of the invention is to realize by following scheme:
A kind of Chinese medicine composition of alleviating physical fatigue, its contained active component is prepared from by the following raw materials in part by weight proportioning: Radix Rhodiolae 30-50 part, Fructus Chaenomelis 20-40 part, Poria 20-30 part and Radix Ophiopogonis 10-20 part.
The Chinese medicine composition of above-mentioned a kind of alleviating physical fatigue, its contained active component is prepared from by the following raw materials in part by weight proportioning: 15 parts of 40 parts of Radix Rhodiolaes, 30 parts of Fructus Chaenomeliss, 25 parts in Poria and Radix Ophiopogonis.
The Chinese medicine composition of above-mentioned alleviating physical fatigue, dosage form are granule, tablet, oral liquid, capsule.
The method of the Chinese medicine composition of above-mentioned alleviating physical fatigue, preparation process is: get Radix Rhodiolae, Fructus Chaenomelis, Poria and medical material merging Radix Ophiopogonis of recipe quantity, decoct with water twice, collecting decoction, relative density is 1.10-1.20 when being concentrated into 65 ℃, adds ethanol and makes the percent by volume that contains the alcohol amount reach 65-85%, stir, leave standstill, filter, relative density was 1.20-1.30 and reclaims ethanol when filtrate decompression was concentrated into 65 ℃, the concentrated solution spray drying, be ground into dry extract, add adjuvant, make required preparation.
The preparation method of the Chinese medicine composition of above-mentioned alleviating physical fatigue, decocting condition is: for the first time amount of water is that the 8-12 of medical material weight doubly measures, and decocts 1-2h, amount of water is that the 6-10 of medical material weight doubly measures for the second time, decocts 1-2h.
The preparation method of the Chinese medicine composition of above-mentioned alleviating physical fatigue, described spray drying condition is: inlet temperature is 80-120 ℃, and leaving air temp is 80-90 ℃, and temperature of charge is 70-90 ℃, and atomizing pressure is the 0.2-0.4 MPa, spray velocity is 5-10ml/s.
The application of above-mentioned Chinese medicine composition in preparation alleviating physical fatigue medicine.
Beneficial effect:
1, from theory of Chinese medical science, Radix Rhodiolae is sweet among the we, and hardship is flat, returns lung, heart channel, and the energy benefiting QI for activating blood circulation is promoted blood circulation and relievingd asthma, and is used for blood stasis due to qi deficiency, obstruction of qi in the chest and cardialgia, apoplectic hemiplegia, asthenia asthma.The acid of Fructus Chaenomelis nature and flavor, temperature is returned liver, spleen channel, energy suppressing the hyperactive liver Shujin, the stomach function regulating removing dampness is used for the arthralgia chiefly caused by damp pathogen contracture, the heavy pain of waist knee joint acid, the convulsion of vomiting and diarrhoea, beriberi edema.Poria is sweet, light, and is flat, GUIXIN, lung, spleen, kidney channel, and the energy promoting diuresis to eliminate damp pathogen, the spleen invigorating mind calming is used for the edema oliguria, the phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in the loose stool, irritability, palpitation with fear insomnia.Sweet, the little hardship of property Radix Ophiopogonis is slightly cold, GUIXIN, lung, stomach warp, and the energy YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire, and is used for dryness of the lung dry cough, and deficiency of YIN consumptive disease is coughed, the sore throat pharyngalgia, Tianjin wound is thirsty, and interior-heat is quenched one's thirst, vexed insomnia, dryness of the intestine constipation.Radix Rhodiolae is a monarch drug in the side, benefiting QI for activating blood circulation, and Fructus Chaenomelis suppressing the hyperactive liver Shujin increases the monarch drug effect, and Poria promoting diuresis to eliminate damp pathogen and lung moistening Radix Ophiopogonis clear away heart-fire and are adjuvant, and all medicines are harmonious, and play the benefiting QI for activating blood circulation effect altogether, are used for alleviating physical fatigue.
2, the present invention writes out a prescription reasonable in designly, and compatibility is rigorous.
3, the present invention consists of Chinese crude drug, has no side effect low price.
The specific embodiment
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention only limits to following example, all technology that realizes based on foregoing of the present invention all belong to scope of the present invention.
1, in conjunction with the specific embodiment, the present invention is further described as follows:
Listed weight proportion takes by weighing raw material required for the present invention in the according to the form below, unit: g
| ? | Radix Rhodiolae | Fructus Chaenomelis | Poria | Radix Ophiopogonis |
| Embodiment 1 | 30 | 40 | 20 | 20 |
| Embodiment 2 | 40 | 30 | 25 | 15 |
| Embodiment 3 | 50 | 20 | 30 | 10 |
Among the present invention, Radix Rhodiolae is the dry root and the rhizome of Crassulaceae plant Radix Rhodiolae.Fructus Chaenomelis is the dry almost ripe fruit of rosaceous plant chaenomeles lagenaria (Chaenomeles speciosa (Sweet) Nakai .).Poria is the dry sclerotia of Polyporaceae fungus Poria Poria cocos (Schw.) Wolf.Be Liliaceae Ophiopogon plant Ophiopogon Radix Ophiopogonis Japonicus(Thunb. Radix Ophiopogonis) dried root of Ker-Gawl..
2. preparation embodiment
More than proportioning raw materials is an example in the table, may further comprise the steps:
The preparation of granule:
Get Radix Rhodiolae 30g, Fructus Chaenomelis 40g, Poria 20g and the also mixing of 20g medical material Radix Ophiopogonis, decoct with water twice, amount of water is 8 times of amounts of medical material weight for the first time, decocts 1h, and amount of water is 6 times of amounts of medical material weight for the second time, decoct 1h, collecting decoction filters, and filtrate is concentrated into relative density 1.10(65 ℃), adding an amount of ethanol makes and contains alcohol amount (volume fraction) and reach 65%, stir, left standstill 24 hours, filter, filtrate recycling ethanol also is concentrated into relative density 1.20(65 ℃) extractum, it is spray-dried that (condition is that inlet temperature is 100 ℃, and leaving air temp is 80 ℃, and temperature of charge is 70 ℃, atomizing pressure is 0.2 MPa, and spray velocity is 5ml/s.), be ground into dry extract, add wherein one or more adjuvants such as suitable dextrin, soluble starch, lactose, sucrose, mannitol again, with an amount of 80% ethanol moistening, the system soft material is crossed 14 mesh sieves and is granulated, 50-80 ℃ of drying, 60 order granulate get granule.
The preparation of tablet:
Get Radix Rhodiolae 40g, Fructus Chaenomelis 30g, Poria 25g and the also mixing of 15g medical material Radix Ophiopogonis, decoct with water twice, add for the first time 10 times of amounts that water is medical material weight, decoct 1.5h, add 8 times of amounts that water is medical material weight for the second time, decoct 1.5h, collecting decoction filters, and filtrate is concentrated into relative density 1.15(65 ℃), adding an amount of ethanol makes and contains alcohol amount (volume fraction) and reach 75%, stir, left standstill 24 hours, filter, filtrate recycling ethanol also is concentrated into relative density 1.25(65 ℃) extractum, it is spray-dried that (condition is that inlet temperature is 120 ℃, and leaving air temp is 90 ℃, and temperature of charge is 80 ℃, atomizing pressure is 0.3 MPa, and spray velocity is 7.5/s.), be ground into dry extract, add one or more adjuvants wherein such as starch, dextrin, Icing Sugar, lactose, microcrystalline Cellulose again, mix homogeneously, with an amount of 80% ethanol moistening, the system soft material, cross 30 mesh sieves and granulate, in 70 ~ 80 ℃ of dryings, with 60 mesh sieve granulate, tabletting, sugar coating, packing, outer package, it is qualified to inspect by ready samples, gets finished product.
The preparation of oral liquid:
Get Radix Rhodiolae 40g, Fructus Chaenomelis 30g, Poria 25g and the also mixing of 15g medical material Radix Ophiopogonis, decoct with water twice, add for the first time 12 times of amounts that water is medical material weight, decoct 2h, add 10 times of amounts that water is medical material weight for the second time, decoct 2h, collecting decoction filters, and filtrate is concentrated into relative density 1.20(65 ℃), adding an amount of ethanol makes and contains alcohol amount (volume fraction) and reach 85%, stir, left standstill 24 hours, filter, filtrate recycling ethanol also is concentrated into relative density 1.30(65 ℃) extractum, it is spray-dried that (condition is that inlet temperature is 100 ℃, and leaving air temp is 90 ℃, and temperature of charge is 90 ℃, atomizing pressure is 0.4 MPa, and spray velocity is 10/s.), be ground into dry extract, calculate: take by weighing dry extract and sucrose respectively in 1:0.05 ~ 0.15 ratio, sucrose is made behind the simple syrup and the clear paste mixing with components by weight percent, add propanoic acid 0.1% or sodium benzoate 0.1% ~ 0.25% etc. as antiseptic, get the oral liquid finished product.
The preparation of capsule:
Get Radix Rhodiolae 50g, Fructus Chaenomelis 20g, Poria 30g and the also mixing of 10g medical material Radix Ophiopogonis, decoct with water twice, add for the first time 10 times of amounts that water is medical material weight, decoct 1.5h, add 8 times of amounts that water is medical material weight for the second time, decoct 1.5h, collecting decoction filters, and filtrate is concentrated into relative density 1.15(65 ℃), adding an amount of ethanol makes and contains alcohol amount (volume fraction) and reach 75%, stir, left standstill 24 hours, filter, filtrate recycling ethanol also is concentrated into relative density 1.25(65 ℃) extractum, it is spray-dried that (condition is that inlet temperature is 120 ℃, and leaving air temp is 90 ℃, and temperature of charge is 90 ℃, atomizing pressure is 0.4 MPa, and spray velocity is 7.5/s.), be ground into dry extract, cross sieve No. 6, reinstall No. 1 capsule get final product finished product.
3. the pharmacodynamic study of alleviating physical fatigue
Fatigue resistant health food of the present invention is the natural constituent of food and medicament dual-purpose plant extract, has the obvious anti-fatigue effect.Below further specify effect of the present invention with the experiment situation, Ministry of Public Health " alleviating physical fatigue functional check method " is pressed in test.
Laboratory animal: Kunming mouse, male, body weight 18-22g, Shanghai Slac Experimental Animal Co., Ltd. provides, production licence: SCXK (Shanghai) 2007-0005.
The experiment medicine: this Chinese medicine composition oral liquid, by above-mentioned oral liquid embodiment method preparation, specification: 10ml/(being equivalent to contain crude drug 18.3g), the self-control of the auspicious Pharmaceutical Technology Co., Ltd of Nanjing Russia and the U.S., lot number: 20100311.Essence side's hall board is supported and capsule, last Nereid side hall bio tech ltd, the strong word G20050641 of state's food, lot number: 20090321.
Dosage: according to " the dose,equivalent ratio table of converting by the surface between humans and animals ", every day, 70 kilograms of people's consumption was 55g, every day, the consumption of every 20g mice was 55*0.0026=0.143g, because of every oral liquid 10ml contains the crude drug amount is 18.3g, the consumption that is every mice is 0.0781ml, therefore determine the low dose of stomach 0.1ml oral liquid of irritating, dosage and high dose are irritated stomach 0.2ml and 0.4ml respectively promptly, the oral liquid of every 20g mouse stomach contained the crude drug amount and was respectively 0.183g every day, 0.366g, 0.732g, then press mice weighing machine, low dosage, middle dosage and high dose are respectively 9.15 g crude drug amount/kg, 18.3g crude drug amount/kg and 36 .6g crude drug amount/kg.
Experimentation: select 50 of healthy mices, tell 10 at random as normal group, all the other 40 mices, be divided into 4 groups at random: high dose group (36.6g crude drug amount/kg), middle dosage group (18.3g crude drug amount/kg), low dose group (9.15g/ crude drug amount kg), positive YAOJING side hall board is supported and Capsules group (340mg/kg), 3 dosage groups wherein, essence side's hall board is supported and Capsules group is pressed above-mentioned dosage gastric infusion, normal group is given the water of 0.2ml, every morning 1 time, continuous 30d, carry out mice swimming with a load attached to the body test, the sheet lead of the negative mice body weight 5% of mouse tail, putting into water temperature is 25 ℃, in the swimming case of depth of water 35cm, exhausts to power the time of death from swimming with the stopwatch record, each is organized data and represents with means standard deviation, carries out the t test between group.The results are shown in Table 1
This Chinese medicine composition of table 1. is to the influence (n=10) of mice swimming with a load attached to the body test
Dosage group low dose group positive drug group in the group normal group high dose group
Depleted swimming time 22.75 ± 1.31 39.61 ± 2. 49** 36.74 ± 5.75**, 31.92 ± 1.64*, 28.49 ± 1.93*
(minute)
Annotate: compare * p＜0.05 * *＜0.01 with normal group
Conclusion: this Chinese medicine composition compares with normal group, obviously prolongs the mice swimming with a load attached to the body time, illustrates that the present invention has effect of relieving physical fatigue, compares with positive drug, and time lengthening illustrates that alleviating physical fatigue effect of the present invention is better than positive drug.
Claims (7)
1. the Chinese medicine composition of an alleviating physical fatigue is characterized in that, its contained active component is prepared from by the following raw materials in part by weight proportioning: Radix Rhodiolae 30-50 part, Fructus Chaenomelis 20-40 part, Poria 20-30 part and Radix Ophiopogonis 10-20 part.
2. a kind of Chinese medicine composition of alleviating physical fatigue according to claim 1 is characterized in that its contained active component is prepared from by the following raw materials in part by weight proportioning: 15 parts of 40 parts of Radix Rhodiolaes, 30 parts of Fructus Chaenomeliss, 25 parts in Poria and Radix Ophiopogonis.
3. the Chinese medicine composition of alleviating physical fatigue as claimed in claim 1 or 2 is characterized in that dosage form is granule, tablet, oral liquid, capsule.
4. one kind prepares the method for the Chinese medicine composition of alleviating physical fatigue as claimed in claim 1 or 2, it is characterized in that preparation process is: Radix Rhodiolae, Fructus Chaenomelis, Poria and medical material merging Radix Ophiopogonis of getting recipe quantity, decoct with water twice, collecting decoction, relative density is 1.10-1.20 when being concentrated into 65 ℃, adding ethanol makes the percent by volume that contains the alcohol amount reach 65-85%, stir, leave standstill, filter, relative density was 1.20-1.30 and reclaims ethanol when filtrate decompression was concentrated into 65 ℃, the concentrated solution spray drying, be ground into dry extract, add adjuvant, make required preparation.
5. as the preparation method of the Chinese medicine composition of alleviating physical fatigue as described in the claim 4, it is characterized in that decocting condition is: for the first time amount of water is that the 8-12 of medical material weight doubly measures, and decocts 1-2h, for the second time amount of water is that the 6-10 of medical material weight doubly measures, and decocts 1-2h.
6. as the preparation method of the Chinese medicine composition of alleviating physical fatigue as described in the claim 4, it is characterized in that, described spray drying condition is: inlet temperature is 80-120 ℃, leaving air temp is 80-90 ℃, temperature of charge is 70-90 ℃, atomizing pressure is the 0.2-0.4 MPa, and spray velocity is 5-10ml/s.
7. the application in preparation alleviating physical fatigue medicine as claim 1 or 2 described Chinese medicine compositions.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102614372A (en) * | 2012-04-23 | 2012-08-01 | 卞毓平 | Chinese medicinal composition for resisting fatigue, and preparation method and application thereof |
| CN104288590A (en) * | 2014-11-05 | 2015-01-21 | 李正梅 | Anti-fatigue traditional Chinese medicine compound as well as preparation method and application thereof |
| CN104998063A (en) * | 2015-08-10 | 2015-10-28 | 青岛琴诚医药技术有限公司 | Anti-fatigue pharmaceutic preparation |
| CN106138804A (en) * | 2016-07-01 | 2016-11-23 | 覃益祥 | A kind of applicable teen-age health care Chinese medicine |
| CN107998279A (en) * | 2017-11-20 | 2018-05-08 | 宁国平衡健康管理有限公司 | A kind of antifatigue Xuancheng's pawpaw cream is grown |
| CN109364117A (en) * | 2018-12-29 | 2019-02-22 | 太原师范学院 | A kind of antifatigue Chinese medicine composition |
-
2011
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Non-Patent Citations (1)
| Title |
|---|
| 《中国组织工程研究与临床康复》 20080624 肖冰 计算机信息技术建立中药抗运动性疲劳复方数据库分析用药规律 5131-5134 1-7 第12卷, 第26期 * |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102614372A (en) * | 2012-04-23 | 2012-08-01 | 卞毓平 | Chinese medicinal composition for resisting fatigue, and preparation method and application thereof |
| CN102614372B (en) * | 2012-04-23 | 2013-09-25 | 北京北陆药业股份有限公司 | Chinese medicinal composition for resisting fatigue, and preparation method and application thereof |
| CN104288590A (en) * | 2014-11-05 | 2015-01-21 | 李正梅 | Anti-fatigue traditional Chinese medicine compound as well as preparation method and application thereof |
| CN104998063A (en) * | 2015-08-10 | 2015-10-28 | 青岛琴诚医药技术有限公司 | Anti-fatigue pharmaceutic preparation |
| CN106138804A (en) * | 2016-07-01 | 2016-11-23 | 覃益祥 | A kind of applicable teen-age health care Chinese medicine |
| CN107998279A (en) * | 2017-11-20 | 2018-05-08 | 宁国平衡健康管理有限公司 | A kind of antifatigue Xuancheng's pawpaw cream is grown |
| CN109364117A (en) * | 2018-12-29 | 2019-02-22 | 太原师范学院 | A kind of antifatigue Chinese medicine composition |
| CN109364117B (en) * | 2018-12-29 | 2021-10-29 | 太原师范学院 | Anti-fatigue traditional Chinese medicine composition |
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