CN102258609B - Sanhuang antipruritic liniment and its preparation method - Google Patents
Sanhuang antipruritic liniment and its preparation method Download PDFInfo
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Abstract
The invention relates to an external-use liniment of a pharmaceutical composition and a preparation method thereof, and specifically relates to a Sanhuang antipruritic liniment and its preparation method. Calculated by 1000 total weight account, the liniment provided by the invention comprises the following raw medicines of: by weight, 20-30 parts of sophora flavescens, 20-30 parts of rheum officinale, 20-30 parts of Baikal Skullcap Root, and 20-30 parts of Cortex Phellodendri. The preparation method provided by the invention comprises the following steps of: mixing the above raw medicines according to the above weight portions, crushing to fine powders, sieving through a sieve and mixing uniformly; adding 3-10 parts of fully swelled carboxymethylcellulose sodium, adding 5-15 parts of melted phenol, uniformly stirring, and adjusting the total amount to 1000 weight portions by adding water. The Sanhuang antipruritic liniment provided by the invention has functions of clearing heat, detoxifying, inducing astringency and relieving itching, can be used to treat skin diseases such as skin redness, hot itching and exudation in the acute phase due to the toxic heat of the skin, has not only a heat-clearing effect but also a convergence effect, and is suitable for various skin injuries with a few exudation in the acute phase; in addition, the Sanhuang antipruritic liniment is a pure traditional Chinese medicinal preparation, is safe to use with no stimulation, can be used for a long time, and has a low price.
Description
Technical field
The present invention relates to externally-applied liniment of a kind of pharmaceutical composition and preparation method thereof, be specifically related to a kind of SANHUANG antipruritic application agent and preparation method thereof.
Background technology
At present clinically for acne, rosacea, furunculosis, eczema, dermatitis (acute stage, have and slightly do not ooze out the person), the case such as herpes zoster (vesicle person appears in acute stage), usually the following Drug therapy that adopts, have such as Acne treatment medicine for external use commonly used: 1. tretinoin: such as tretinoin emulsifiable paste (15～20 yuan), Avita Gel (35 yuan), isotretinoin gel (more than 50 yuan) etc., but can occur slight irritant reaction (such as local flushing, desquamation or burn feeling) after the medication.2. antibiotics: such as 1%～2% erythromycin ointment (1～2 yuan), lincomycin VB6 ointment (about 30 yuan), be suitable for the erythra of infection.This two classes medicine effect is limited, and part patient has sense of discomfort.Treatment rosacea medicine for external use commonly used has more than the 0.75% Metrogel 20g(20 unit), antibacterial action is arranged, short-term is used effectively; Compound sulfur lotion or 5% sulphur ointment (5～10 yuan) have certain curative effect, but skin irritation reaction and pungent taste are often arranged.Treatment furunculosis medicine for external use commonly used has: about mupirocin ointment 5g(15 unit) effect is limited.Treatment eczema commonly used, the medicine for external use of dermatitis have external glucocorticoid paste or 25%～40% zinc oxid oil or paste (generally being hospital-made); Mostly be greatly ointment in the product of listing, the life-time service Hormonal ointment easily produces various untoward reaction, and has been unsuitable for the person of oozing out.The medicine for external use for the treatment of herpes zoster (vesicle person appears in acute stage) commonly used has: use Calamine Lotion 100ml, 3% acyclovir ointment 10g, 1% Denavir 10g when bleb liquid is broken; Behind the herpes ulceration with 3% boric acid solution 200ml, mupirocin ointment 5g.
Summary of the invention
The objective of the invention is provides a kind of SANHUANG antipruritic application agent and preparation method thereof according to above-mentioned the deficiencies in the prior art part, and this liniment is pure Chinese medicinal preparation, is used for the disease that the skin pyretic toxicity is had an itch, and effect is very obvious.
The object of the invention realizes being finished by following technical scheme:
A kind of SANHUANG antipruritic application agent is characterized in that described liniment calculates with 1000 total weight parts, and its crude drug forms and the shared weight portion of consumption is respectively: Radix Sophorae Flavescentis 20-30, Radix Et Rhizoma Rhei 20-30, Radix Scutellariae 20-30, Cortex Phellodendri 20-30.
The crude drug of described liniment forms and the shared weight portion of consumption is respectively: Radix Sophorae Flavescentis 20-30, Radix Et Rhizoma Rhei 20-30, Radix Scutellariae 20-30, Cortex Phellodendri 20-30, Herba Hedyotidis Diffusae 20-30, Herba Taraxaci 20-30.
The crude drug of described liniment forms and the shared weight portion of consumption is respectively: Radix Sophorae Flavescentis 20-30, Radix Et Rhizoma Rhei 20-30, Radix Scutellariae 20-30, Cortex Phellodendri 20-30, Radix Rehmanniae 20-30, Cortex Mori 15-30.
The crude drug of described liniment forms and the shared weight portion of consumption is respectively: Radix Sophorae Flavescentis 20-30, Radix Et Rhizoma Rhei 20-30, Radix Scutellariae 20-30, Cortex Phellodendri 20-30, Flos Lonicerae 15-20, Flos Chrysanthemi Indici 10-20.
The crude drug of described liniment forms and the shared weight portion of consumption is respectively: Radix Sophorae Flavescentis 20-30, Radix Et Rhizoma Rhei 20-30, Radix Scutellariae 20-30, Cortex Phellodendri 20-30, Rhizoma Smilacis Glabrae 20-30.
The crude drug of described liniment forms and the shared weight portion of consumption is respectively: Radix Sophorae Flavescentis 20-30, Radix Et Rhizoma Rhei 20-30, Radix Scutellariae 20-30, Cortex Phellodendri 20-30, Radix Gentianae 10-15, Gardenia 20-30.
A kind of preparation method of SANHUANG antipruritic application agent is characterized in that the above-mentioned raw materials medicine is formed, and according to above-mentioned weight portion, mixes, is ground into fine powder, crosses afterwards mesh sieve, mixing; Add the sodium carboxymethyl cellulose 3-10 weight portion of complete swelling, add again the phenol 5-15 weight portion that has melted, stir evenly, add water and adjust total amount to 1000 weight portion, and get final product.
Advantage of the present invention is, heat-clearing and toxic substances removing, relieving iching by astringing, and the dermatosis such as be used for acute stage red swelling of the skin, pruritus due to heat that skin causes because of hyperactivity of toxic heat, ooze out, existing heat clearing away effect has again astriction, is suitable for acute stage with the various skin lesion that ooze out on a small quantity; Pure Chinese medicinal preparation, use safe, non-stimulated, but life-time service; Price is lower.
The specific embodiment
By the following examples feature of the present invention and other correlated characteristic are described in further detail, so that technical staff's of the same trade understanding:
Embodiment one:
Crude drug forms and consumption is: Radix Sophorae Flavescentis 25g, Radix Et Rhizoma Rhei 25g, Radix Scutellariae 25g, Cortex Phellodendri 25g.
Above-mentioned raw materials is formed according to above-mentioned weight portion, mix, be ground into fine powder, cross afterwards 80 mesh sieves, mixing; Add the sodium carboxymethyl cellulose 5g of complete swelling, add again the phenol 10g that has melted, stir evenly, add water and adjust total amount to 1000ml.
The using method of the described liniment of present embodiment is as follows:
With adopt above-mentioned preparation method system liniment be distributed into bottle by 100 ml/ bottles.Partial smearing, 1 time every night, with before shaking up.2 weeks were 1 course for the treatment of.
Embodiment two: present embodiment and the difference of embodiment one be crude drug form different, present embodiment for the patient that the acne disease is arranged.
Crude drug forms: Radix Sophorae Flavescentis 25g, Radix Et Rhizoma Rhei 25g, Radix Scutellariae 25g, Cortex Phellodendri 25g, Herba Hedyotidis Diffusae 30, Herba Taraxaci 30.2 weeks were 1 course for the treatment of.
The state of an illness symptom of acne: whelk, blackhead, serious symptom have pustule, tuberosity, cyst.
Below be that present embodiment and contrast groups are applied to clinical report: every group of patient 20 people.
| Group | Treatment time (week) | Clinical cure (example) | Take a turn for the better (example) | (example) do not heal |
| Adopt the tretinoin group | 2 | 1 | 3 | 16 |
| Adopt the tretinoin group | 4 | 4 | 4 | 12 |
| One group of embodiment | 2 | 0 | 6 | 14 |
| One group of embodiment | 4 | 8 | 8 | 4 |
| Two groups of embodiment | 2 | 4 | 6 | 10 |
| Two groups of embodiment | 4 | 12 | 4 | 4 |
With reference to " disease of tcm Standardization of diagnosis and curative effect ", above-mentioned acne criterion of therapeutical effect is as follows:
Clinical cure: skin lesion is disappeared, and subjective symptoms disappears;
Take a turn for the better: subjective symptoms obviously alleviates, and skin lesion disappears more than 30%;
Do not heal: skin lesion and symptom be the unchanged or less than 30% that disappears all.
Can be seen by above-mentioned routine table, compare with existing medicine, embodiment one all is better than the contrast groups medicine with the effect of embodiment two, and the effect of embodiment two is better than the effect of embodiment one, price has no side effect far below upper two class medicines, and 100% patient to react above-described embodiment medicine clearing heat and anti-inflammatory functions strong, can take effect rapidly, without uncomfortable sensation.
Embodiment three: present embodiment and the difference of embodiment one be crude drug form different, present embodiment for the patient that the rosacea disease is arranged.
Crude drug forms: Radix Sophorae Flavescentis 25g, Radix Et Rhizoma Rhei 25g, Radix Scutellariae 25g, Cortex Phellodendri 25g, the Radix Rehmanniae 30, Cortex Mori 30.2 weeks were 1 course for the treatment of.
Rosacea state of an illness symptom: the nose flushing, obvious when excited, pimple, pustule, telangiectasis is obvious, and pachyderma forms pachydermatosis at last.
Below be that present embodiment and contrast groups are applied to clinical report: every group of patient 20 people.
| Group | Treatment time (week) | Clinical cure (example) | Take a turn for the better (example) | (example) do not heal |
| Compound sulfur lotion or 5% sulphur ointment | 2 | 0 | 2 | 18 |
| Compound sulfur lotion or 5% sulphur ointment | 4 | 2 | 6 | 12 |
| One group of embodiment | 2 | 0 | 8 | 12 |
| One group of embodiment | 4 | 4 | 12 | 4 |
| Three groups of embodiment | 2 | 4 | 10 | 6 |
| Three groups of embodiment | 4 | 8 | 8 | 4 |
With reference to " disease of tcm Standardization of diagnosis and curative effect ", above-mentioned acne rosacea criterion of therapeutical effect is as follows:
Clinical cure: skin lesion disappears.
Take a turn for the better: the part skin lesion alleviates, or disappears more than 30%.
Do not heal: the unchanged or less than 30% that disappears of skin lesion.
Can be seen by above-mentioned routine table, compare with existing medicine, embodiment one all is better than the contrast groups medicine with the effect of embodiment three, and the effect of embodiment three is better than the effect of embodiment one, and it is strong that 100% patient reacts the heat clearing away of above-described embodiment medicine, removing heat from blood, antiinflammation, instant effect, non-stimulated sensation, but life-time service.
Embodiment four: present embodiment and the difference of embodiment one be crude drug form different, present embodiment for the patient that the furunculosis disease is arranged.
Crude drug forms: Radix Sophorae Flavescentis 25g, Radix Et Rhizoma Rhei 25g, Radix Scutellariae 25g, Cortex Phellodendri 25g, Flos Chrysanthemi Indici 30, Flos Lonicerae 20.1 week was 1 course for the treatment of.
Furunculosis state of an illness symptom: exceed the cerise hair follicle pimple of skin, cumulative large, pain became pus in 2-3 days, namely healed after bursting.Whole body distributes everywhere, or repeatedly shows effect at certain position.
Below be that present embodiment and contrast groups are applied to clinical report: every group of patient 20 people.
| Group | Treatment time (week) | Clinical cure (example) | Take a turn for the better (example) | (example) do not heal |
| Mupirocin ointment | 0.5 | 2 | 8 | 10 |
| Mupirocin ointment | 1 | 4 | 6 | 10 |
| One group of embodiment | 0.5 | 2 | 10 | 8 |
| One group of embodiment | 1 | 8 | 8 | 4 |
| Four groups of embodiment | 0.5 | 4 | 6 | 10 |
| Four groups of embodiment | 1 | 4 | 14 | 2 |
With reference to " disease of tcm Standardization of diagnosis and curative effect ", above-mentioned furunculosis criterion of therapeutical effect is as follows:
Clinical cure: furuncle and phyma dissipates or the rear healing of bursting, and General Symptoms disappears.
Take a turn for the better: send out again the furuncle and phyma number and reduce sx↓.
Do not heal: this heals that rises furuncle and phyma, can not control.
Can be seen by above-mentioned routine table, compare with existing medicine, embodiment one all is better than the Comparative Examples medicine with the effect of embodiment four, and the effect of embodiment four is better than the effect of embodiment one, above-described embodiment medicine has preferably antipyretic and antidote functions, furunculosis for repeatedly outbreak has preferably curative effect, and can reduce recurrence.
Embodiment five: present embodiment and the difference of embodiment one be crude drug form different, present embodiment for the patient that eczema, dermatitis (acute stage has and slightly do not ooze out the person) disease are arranged.
Crude drug forms: Radix Sophorae Flavescentis 25g, Radix Et Rhizoma Rhei 25g, Radix Scutellariae 25g, Cortex Phellodendri 25g, Rhizoma Smilacis Glabrae 30.2 weeks were 1 course for the treatment of.
The state of an illness symptom of eczema, dermatitis (acute stage has and slightly do not ooze out the person): acute eczema has erythema, pimple, vesicle, oozes out, and is symmetrical, acutely scratches where it itches.
Below be that present embodiment and contrast groups are applied to clinical report: every group of patient 20 people.
| Group | Treatment time (week) | Clinical cure (example) | Take a turn for the better (example) | (example) do not heal |
| External glucocorticoid paste | 2 | 0 | 8 | 12 |
| External glucocorticoid paste | 4 | 2 | 10 | 8 |
| One group of embodiment | 2 | 0 | 10 | 10 |
| One group of embodiment | 4 | 4 | 10 | 6 |
| Five groups of embodiment | 2 | 2 | 12 | 6 |
| Five groups of embodiment | 4 | 8 | 10 | 2 |
With reference to " disease of tcm Standardization of diagnosis and curative effect ", above-mentioned eczema criterion of therapeutical effect is as follows:
Clinical cure: skin lesion disappears.
Take a turn for the better: skin lesion disappears more than 30%.
Do not heal: the skin lesion less than 30% that disappears.
Can be seen by above-mentioned routine table, compare with existing medicine, embodiment one all is better than the Comparative Examples medicine with the effect of embodiment five, and the effect of embodiment five is better than the effect of embodiment one, and being applicable to acute stage eczema, dermatitis has and slightly do not ooze out the person, heat clearing away, antiinflammatory and astriction are obvious, owing to be Chinese medicine preparation without hormone, can use safely in tender and lovely skin places such as faces, but and life-time service, and 100% patient reacts instant effect, without uncomfortable sensation.
Embodiment six: present embodiment and the difference of embodiment one be crude drug form different, present embodiment for the patient that herpes zoster (vesicle person appears in acute stage) disease is arranged.
Crude drug forms: Radix Sophorae Flavescentis 25g, Radix Et Rhizoma Rhei 25g, Radix Scutellariae 25g, Cortex Phellodendri 25g, Radix Gentianae 15, Gardenia 30.1 week was 1 course for the treatment of.
Herpes zoster (vesicle person appears in acute stage) state of an illness symptom: one-sided skin has the vesicle of Semen phaseoli radiati size, is zonal distribution, sharp ache.
Below be that present embodiment and contrast groups are applied to clinical report: every group of patient 20 people.
| Group | Treatment time (week) | Clinical cure (example) | Take a turn for the better (example) | (example) do not heal |
| With Calamine Lotion, acyclovir ointment, Denavir | 1 | 0 | 4 | 16 |
| With Calamine Lotion, acyclovir ointment, Denavir | 2 | 0 | 8 | 12 |
| Boric acid solution, mupirocin ointment | 1 | 0 | 4 | 16 |
| Boric acid solution, mupirocin ointment | 2 | 0 | 6 | 14 |
| One group of embodiment | 1 | 0 | 8 | 12 |
| One group of embodiment | 2 | 3 | 11 | 6 |
| Six groups of embodiment | 1 | 6 | 8 | 6 |
| Six groups of embodiment | 2 | 10 | 6 | 4 |
With reference to " disease of tcm Standardization of diagnosis and curative effect ", above-mentioned Herpes Zoster standard is as follows:
Clinical cure: deflorescence, clinical sign disappears, without the pain sequela.
Take a turn for the better: deflorescence is about 30%, and pain obviously alleviates.
Do not heal: deflorescence less than 30% still has pain.
Can be seen by above-mentioned routine table, compare with existing medicine, embodiment one all is better than the Comparative Examples medicine with the effect of embodiment six, and the effect of embodiment six is better than the effect of embodiment one, and 100% patient reacts above-described embodiment medicine instant effect, without uncomfortable sensation, the existing heat clearing away effect of this medicine liniment, astriction is arranged again, be suitable for the herpes zoster acute stage various skin lesion when vesicle occurring.
The sodium carboxymethyl cellulose that those skilled in the art obviously know in above-described embodiment Chinese medicine component is as thickening agent, and phenol is as antiseptic, and how much obviously can increasing and decreasing in right amount according to concrete needs of its addition do not repeat them here.
Claims (2)
1. SANHUANG antipruritic application agent, it is characterized in that described liniment calculates with 1000 total weight parts, its crude drug forms and the shared weight portion of consumption is respectively: Radix Sophorae Flavescentis 20-30, Radix Et Rhizoma Rhei 20-30, Radix Scutellariae 20-30, Cortex Phellodendri 20-30, Herba Hedyotidis Diffusae 20-30, Herba Taraxaci 20-30.
2. the preparation method of a SANHUANG antipruritic application agent is characterized in that described method is that the above-mentioned raw materials medicine is formed, and according to above-mentioned weight portion, mixes, is ground into fine powder, crosses afterwards mesh sieve, mixing; Add the sodium carboxymethyl cellulose 3-10 weight portion of complete swelling, add again the phenol 5-15 weight portion that has melted, stir evenly, add water and adjust total amount to 1000 weight portion, and get final product.
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| CN102784223A (en) * | 2012-07-23 | 2012-11-21 | 杭州市中医院 | Application of three-medicine ointment in preparation of drugs used for preventing and curing phlebitis |
| CN102908411A (en) * | 2012-11-21 | 2013-02-06 | 安文娟 | Ointment for treating acne |
| CN104523529A (en) * | 2015-01-08 | 2015-04-22 | 江苏省中医院 | Traditional Chinese medicine wet tissue for skin decontamination, preparation method thereof and traditional Chinese medicine composition |
| CN105055869A (en) * | 2015-07-21 | 2015-11-18 | 徐以燕 | Traditional Chinese medicinal external liniment and nursing method for treating rosacea with syndrome of heat-toxin exuberance |
| CN108378991A (en) * | 2018-05-07 | 2018-08-10 | 浙江卫星新材料科技有限公司 | Paper diaper containing kuh-seng |
| CN109646612B (en) * | 2019-02-28 | 2021-06-08 | 嘉兴市中医医院 | Dampness-eliminating and itching-relieving mixture and preparation method thereof |
| CN110755508B (en) * | 2019-12-25 | 2021-11-26 | 长春雷允上药业有限公司 | Traditional Chinese medicine composition for relieving swelling and itching and preparation method thereof |
| CN114452318A (en) * | 2022-02-22 | 2022-05-10 | 威高(北京)医疗科技有限公司 | Anti-inflammatory traditional Chinese medicine composition for sanitary products and preparation method and application thereof |
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