CN102247447B - Formula of traditional Chinese medicine external-washing medicinal powder and effervescent tablet for treating chilblain and preparation method thereof - Google Patents
Formula of traditional Chinese medicine external-washing medicinal powder and effervescent tablet for treating chilblain and preparation method thereof Download PDFInfo
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- CN102247447B CN102247447B CN201010601980A CN201010601980A CN102247447B CN 102247447 B CN102247447 B CN 102247447B CN 201010601980 A CN201010601980 A CN 201010601980A CN 201010601980 A CN201010601980 A CN 201010601980A CN 102247447 B CN102247447 B CN 102247447B
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- 208000010445 Chilblains Diseases 0.000 title claims abstract description 39
- 239000000843 powder Substances 0.000 title claims abstract description 34
- 239000007938 effervescent tablet Substances 0.000 title claims abstract description 19
- 239000003814 drug Substances 0.000 title claims abstract description 13
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 238000005406 washing Methods 0.000 title abstract 3
- 239000008187 granular material Substances 0.000 claims abstract description 24
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 21
- 238000002156 mixing Methods 0.000 claims abstract description 15
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims abstract description 12
- 229920002472 Starch Polymers 0.000 claims abstract description 12
- 239000008107 starch Substances 0.000 claims abstract description 12
- 235000019698 starch Nutrition 0.000 claims abstract description 12
- 238000001035 drying Methods 0.000 claims abstract description 11
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims abstract description 7
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims abstract description 7
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims abstract description 7
- 229940093429 polyethylene glycol 6000 Drugs 0.000 claims abstract description 7
- 238000005303 weighing Methods 0.000 claims abstract description 7
- 229910052708 sodium Inorganic materials 0.000 claims abstract description 6
- 239000011734 sodium Substances 0.000 claims abstract description 6
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims abstract description 6
- 235000017557 sodium bicarbonate Nutrition 0.000 claims abstract description 6
- 229940079593 drug Drugs 0.000 claims abstract description 4
- 238000010298 pulverizing process Methods 0.000 claims abstract description 4
- 238000003756 stirring Methods 0.000 claims abstract description 4
- 239000000463 material Substances 0.000 claims abstract description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 17
- 235000008216 herbs Nutrition 0.000 claims description 12
- 241000628997 Flos Species 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 10
- 206010013786 Dry skin Diseases 0.000 claims description 6
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 5
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims description 5
- 239000002671 adjuvant Substances 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 3
- 239000012567 medical material Substances 0.000 claims description 3
- 241000227129 Aconitum Species 0.000 abstract 2
- 241000722953 Akebia Species 0.000 abstract 2
- 244000020518 Carthamus tinctorius Species 0.000 abstract 2
- 235000003255 Carthamus tinctorius Nutrition 0.000 abstract 2
- 244000037364 Cinnamomum aromaticum Species 0.000 abstract 2
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 abstract 2
- 241000112528 Ligusticum striatum Species 0.000 abstract 2
- 238000005469 granulation Methods 0.000 abstract 2
- 230000003179 granulation Effects 0.000 abstract 2
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 abstract 1
- 238000004806 packaging method and process Methods 0.000 abstract 1
- 238000003825 pressing Methods 0.000 abstract 1
- 239000002994 raw material Substances 0.000 abstract 1
- 239000003826 tablet Substances 0.000 abstract 1
- 239000008280 blood Substances 0.000 description 12
- 210000004369 blood Anatomy 0.000 description 10
- 208000003251 Pruritus Diseases 0.000 description 4
- 230000017531 blood circulation Effects 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 208000005392 Spasm Diseases 0.000 description 3
- 208000025865 Ulcer Diseases 0.000 description 3
- 210000004204 blood vessel Anatomy 0.000 description 3
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000036407 pain Effects 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 230000035699 permeability Effects 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 231100000397 ulcer Toxicity 0.000 description 2
- 206010010356 Congenital anomaly Diseases 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- 208000001034 Frostbite Diseases 0.000 description 1
- 208000008454 Hyperhidrosis Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000002720 Malnutrition Diseases 0.000 description 1
- 208000007101 Muscle Cramp Diseases 0.000 description 1
- 206010039509 Scab Diseases 0.000 description 1
- 244000061458 Solanum melongena Species 0.000 description 1
- 206010053615 Thermal burn Diseases 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 230000000146 antalgic effect Effects 0.000 description 1
- 230000001139 anti-pruritic effect Effects 0.000 description 1
- 239000003908 antipruritic agent Substances 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
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- 210000000624 ear auricle Anatomy 0.000 description 1
- 230000002497 edematous effect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 230000008338 local blood flow Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 210000002464 muscle smooth vascular Anatomy 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 208000037920 primary disease Diseases 0.000 description 1
- 210000000664 rectum Anatomy 0.000 description 1
- 208000009146 rhinoscleroma Diseases 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 206010040882 skin lesion Diseases 0.000 description 1
- 231100000444 skin lesion Toxicity 0.000 description 1
- 210000002460 smooth muscle Anatomy 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 208000037816 tissue injury Diseases 0.000 description 1
- 230000036269 ulceration Effects 0.000 description 1
- 235000000112 undernutrition Nutrition 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
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Abstract
The invention relates to formulae of traditional Chinese medicine external-washing medicinal powder and an effervescent tablet for treating chilblain and preparation methods thereof. 1) The formula of the medicinal powder comprises 3750 g of safflower, 6250 g of cassia twig, 3750 g of ligusticum wallichii, 3125 g of monkshood, and 3125 g of akebia stem. 2) The preparation method of the medicinal powder comprises the following steps: weighing the traditional Chinese medicine according to the formula, pulverizing the medicines into 200-mesh powder, fully and uniformly stirring, packaging according to an amount of 20 g/bag so as to obtain 1000 bags. 3) The formula of the effervescent tablet comprises the following main raw materials: 690 g of safflower, 1110 g of cassia twig, 690 g of ligusticum wallichii, 520 g of monkshood, and 520 g of akebia stem; and the following auxiliary materials: 650 g of citric acid, 780 g of sodium bicarbonate, 1105 g of starch, 260 g of sodium carboxymethyl starch, 195 g of hydroxypropyl cellulose, and 195 g of polyethylene glycol 6000. 4) The preparation method of the effervescent tablet comprises the following steps: (1) preparing extract powder; (2) dividing the extract powder into two parts, adding citric acid fine powder into one part, well mixing, performing granulation, drying, and granule finishing; adding sodium bicarbonate fine powder into the other part, well mixing, performing granulation, drying, and granule finishing; (3) adding hydroxypropyl cellulose and polyethylene glycol 6000 into the granules, well mixing, pressing into tablets to obtain 1000 chilblain external-washing effervescent tablets.
Description
Technical field
The present invention relates to prescription of the outer medicament of a kind of Chinese medicine and preparation method thereof, the prescription that relates in particular to a kind of external washout with traditional Chinese herbs medicated powder of treating chilblain, effervescent tablet with and preparation method thereof.
Background technology
chilblain is that vesicle, erosion and ulcer can appear in indefinite border because the cold locality inflammation that causes is damaged, and the chilblain skin lesion is a pruritus property locality edematous erythema; Chilblain is from the beginning of being locality Semen Viciae fabae to nail cover size aubergine lump or scleroma, and the edge is scarlet, and central authorities are livid purple, and that touches is ice-cold; That presses fades, and goes to press the back to recover slower, and there are the sense of expanding, pruritus in conscious part; Meet after the heat more very, severe patient can have vesicle, forms ulcer behind the ulceration, does not prolongedly heal.
chilblain is the commonly encountered diseases in winter, and according to the interrelated data statistics, China has 200,000,000 people to receive the puzzlement of chilblain every year; Wherein mainly be child, women and old people; Chilblain is in case take place, and often more difficult rapid healing in cold season just can heal after will waiting day cyclostrophic warm gradually; Want to reduce the generation of chilblain, key is into just beginning prevention before the winter.
Perniosis is the abnormal response that body takes place cold; The locality scytitis infringement that causes by cold when chilblain is severe winter or season in the early spring; Occur in the tip and the naked position of limbs well, like hands, foot, nose, in one's ear, ear-lobe dough-making powder buccal, after late autumn; Temperature reduces suddenly, and the blood flow in the peripheral vessel also becomes slow immediately.When temperature was lower than 10 ℃, the small subcutaneous arteries at above-mentioned position was met cold contraction, and venous return is not smooth; Thereby generation chilblain; Also have the part patient to cause thrombosis and bring out chilblain because of blood vessel congenital variation, angiostenosis, therefore, anti-frostbite should be directed against its pathogeny; Take measures in advance, the effect of getting twice the result with half the effort is often arranged.
modern medicine thinks that chilblain is because patient's skin tolerance to cold is poor, adds cold invasion and attack, the skin heart of tip is shunk or spasm takes place, and causes the local blood circulation obstacle, makes oxygen and undernutrition and the tissue injury that takes place.Present medical evidence: the basic reason that chilblain produces is that the smooth muscle in the body surface far-end venae subcutaneae blood capillary is when spasm taking place when running into low temperature; Just can reduce the permeability of blood vessel; Make blood produce trapping phenomena; And the generation chilblain, Here it is why chilblain all can show the basic reason of blue or green stasis of blood phenomenon.The optimum method that solves is at first to remove the vascular smooth muscle spasm; Recover the permeability of venous capillary; Blood flow increasing; Be aided with again antiinflammatory, analgesia, antipruritic after, just can alleviate about patient general half a day to one day and eliminate symptom accepting preferably, the person of seriously not festering can subside a swelling and scab about 3 days.
Chinese medicine is thought primary disease is because patient's YANG QI deficiency, and the heresy of diseases caused by exogenous pathogenic factor cold-damp makes QI-blood circulation not smooth, stagnation of blood stasis and falling ill; In addition, the back human body vim and vigour of enduring cold are not prosperous, and reasons such as anemia cause the blood vessel blood stasis, because blood stasis; So have swollenly, because blood stasis itches so have, unique way of radical cure chilblain is got through blood stasis exactly; Other way all to no effect has only blood stasis to get through, and could cure.
Summary of the invention
The technical problem that the present invention will solve provide a kind of wash external washout with traditional Chinese herbs medicated powder with convenient, efficacious therapy chilblain, effervescent tablet prescription with and preparation method thereof.
For solving its technical problem, adopt following technical scheme:
1) prescription of treatment chilblain external washout with traditional Chinese herbs medicated powder:
Flos Carthami 3750g, Ramulus Cinnamomi 6250g, Rhizoma Chuanxiong 3750 g, Radix Aconiti 3125g, Caulis Akebiae 3125g;
Herbal pharmacology effect: Ramulus Cinnamomi diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins; Flos Carthami invigorate blood circulation latus rectum, eliminating stasis to stop pain; Hot warm logical, the blood circulation promoting and blood stasis dispelling that looses of Rhizoma Chuanxiong; The Radix Aconiti anti-inflammatory and antalgic; Caulis Akebiae is antibiotic.
2) method for preparing of treatment chilblain external washout with traditional Chinese herbs medicated powder:
Take by weighing Flos Carthami 3750g, Ramulus Cinnamomi 6250g, Rhizoma Chuanxiong 3750 g, Radix Aconiti 3125g, Caulis Akebiae 3125g; The pulverize separately pulverizing becomes 200 orders, stirs, and packs according to 20g/, obtains 1000 bags.
3) prescription of treatment chilblain wash-out effervescent tablet:
Main material: Flos Carthami 690g, Ramulus Cinnamomi 1110g, Rhizoma Chuanxiong 690g, Radix Aconiti 520g, Caulis Akebiae 520g;
Adjuvant: citric acid 650g, sodium bicarbonate 780g, starch 1105g, carboxymethyl starch sodium 260g, hydroxypropyl cellulose 195g, polyethylene glycol 6000 195g.
4) method for preparing of treatment chilblain wash-out effervescent tablet
(1) system extract powder: take by weighing medical material decocte with water such as Flos Carthami 690g, Ramulus Cinnamomi 1110g, Rhizoma Chuanxiong 690g, Radix Aconiti 520g, Caulis Akebiae 520g 3 times, add 3 times of water for the first time, add 2 times of water for the second time; The 3rd water that doubles merges three times decocting liquid, filters; Filtrating is concentrated into the thick paste that relative density is 1.25-1.30, adds starch 1105g, carboxymethyl starch sodium 260g, mixing; Cold drying is ground into fine powder, and is subsequent use;
(2) above-mentioned extract powder is divided into two parts, a adding citric acid 650g fine powder mixing is processed granule, 80 ℃ of dryings, and granule is subsequent use behind the granulate; Another part adds sodium bicarbonate 780g fine powder mixing, processes granule, 80 ℃ of dryings, and granule is subsequent use behind the granulate;
(3) above-mentioned granule adds hydroxypropyl cellulose 195g, polyethylene glycol 6000 195g, mixing, and compacting promptly gets 1000 of chilblain wash-out effervescent tablets in flakes.
Method for using: 1, treatment chilblain external washout with traditional Chinese herbs medicated powder one bag boils with the about 2-4 jin of cold water and rises, and pours foot soak bucket into, and the suitable water temperature of not scalding puts into hands and foot steeped 25-40 minute; 2, the external washout with traditional Chinese herbs effervescent tablet 4-6 of treatment chilblain adds the proper temperature warm water 2-4 jin that does not scald; 3, treatment chilblain external washout with traditional Chinese herbs medicated powder one bag boils with the about 2-4 jin of cold water and rises, and pours foot soak bucket into, puts into the external washout with traditional Chinese herbs effervescent tablet 4-6 of treatment chilblain again, and the suitable water temperature of not scalding is put into hands and 25-40 minute better effects if of foot bubble.Every day 2 times, 10 is a course of treatment, pruritus pain, sx after the course of treatment.
Said method also can cooperate the foot care basin that the therapeutic massage function is arranged that can buy on the market to use.
Beneficial effect: the present invention is easy to use, and main composition is a Chinese crude drug, has no side effect; Adjuvant is easy to get, and cost is low, safety and be beneficial to large-scale industrialized production.
The specific embodiment
One, preparation treatment chilblain external washout with traditional Chinese herbs medicated powder:
Take by weighing Flos Carthami 3750g, Ramulus Cinnamomi 6250g, Rhizoma Chuanxiong 3750 g, Radix Aconiti 3125g, Caulis Akebiae 3125g; The pulverize separately pulverizing becomes 200 orders, stirs, and packs according to 20g/, obtains 1000 bags.
Ratio plus-minus dose in above-mentioned prescription can make the medicament greater or less than above-mentioned amount.
Two, the wash-out effervescent tablet of preparation treatment chilblain:
(1) takes by weighing medical material decocte with water such as Flos Carthami 690g, Ramulus Cinnamomi 1110g, Rhizoma Chuanxiong 690g, Radix Aconiti 520g, Caulis Akebiae 520g 3 times, add 3 times of water for the first time, add 2 times of water for the second time; The 3rd water that doubles merges three times decocting liquid, filters; Filtrating is concentrated into the thick paste that relative density is 1.25-1.30, adds starch 1105g, carboxymethyl starch sodium 260g, mixing; Cold drying is ground into fine powder, and is subsequent use;
(2) above-mentioned extractum fine powder is divided into two parts, a adding citric acid 650g fine powder mixing is processed granule, 80 ℃ of dryings, and granule is subsequent use behind the granulate; Another part adds sodium bicarbonate 780g fine powder mixing, processes granule, 80 ℃ of dryings, and granule is subsequent use behind the granulate
(3) above-mentioned granule adds hydroxypropyl cellulose 195g, polyethylene glycol 6000 195g, mixing, and compacting promptly gets 1000 of chilblain wash-out effervescent tablets in flakes.
Ratio plus-minus dose in above-mentioned prescription can make the medicament greater or less than above-mentioned amount.
Claims (4)
1. an external washout with traditional Chinese herbs medicated powder of treating chilblain is processed by the crude drug of following weight: Flos Carthami 3750g, Ramulus Cinnamomi 6250g, Rhizoma Chuanxiong 3750g, Radix Aconiti 3125g, Caulis Akebiae 3125g.
2. method for preparing of treating chilblain external washout with traditional Chinese herbs medicated powder, its preparation method may further comprise the steps: take by weighing Flos Carthami 3750g, Ramulus Cinnamomi 6250g, Rhizoma Chuanxiong 3750g, Radix Aconiti 3125g, Caulis Akebiae 3125g; The pulverize separately pulverizing becomes 200 orders, stirs, and packs according to 20g/, obtains 1000 bags.
3. wash-out effervescent tablet of treating chilblain, this wash-out effervescent tablet is processed by the crude drug and the adjuvant of following weight:
Main material: Flos Carthami 690g, Ramulus Cinnamomi 1110g, Rhizoma Chuanxiong 690g, Radix Aconiti 520g, Caulis Akebiae 520g;
Adjuvant: citric acid 650g, sodium bicarbonate 780g, starch 1105g, carboxymethyl starch sodium 260g, hydroxypropyl cellulose 195g, polyethylene glycol 6000 195g.
4. method for preparing of treating the chilblain wash-out effervescent tablet, its preparation method may further comprise the steps:
(1) system extract powder: take by weighing medical material decocte with water such as Flos Carthami 690g, Ramulus Cinnamomi 1110g, Rhizoma Chuanxiong 690g, Radix Aconiti 520g, Caulis Akebiae 520g 3 times, add 3 times of water for the first time, add 2 times of water for the second time; The 3rd water that doubles merges three times decocting liquid, filters; Filtrating is concentrated into the thick paste that relative density is 1.25-1.30, adds starch 1105g, carboxymethyl starch sodium 260g, mixing; Cold drying is ground into fine powder, and is subsequent use;
(2) above-mentioned extract powder is divided into two parts, a adding citric acid 650g fine powder mixing is processed granule, 80 ℃ of dryings, and granule is subsequent use behind the granulate; Another part adds sodium bicarbonate 780g fine powder mixing, processes granule, 80 ℃ of dryings, and granule is subsequent use behind the granulate;
(3) above-mentioned granule adds hydroxypropyl cellulose 195g, polyethylene glycol 6000 195g, mixing, and compacting promptly gets 1000 of chilblain wash-out effervescent tablets in flakes.
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| CN201010601980A CN102247447B (en) | 2010-12-23 | 2010-12-23 | Formula of traditional Chinese medicine external-washing medicinal powder and effervescent tablet for treating chilblain and preparation method thereof |
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| CN201010601980A CN102247447B (en) | 2010-12-23 | 2010-12-23 | Formula of traditional Chinese medicine external-washing medicinal powder and effervescent tablet for treating chilblain and preparation method thereof |
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| CN102247447B true CN102247447B (en) | 2012-10-03 |
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| CN112999177A (en) * | 2021-01-30 | 2021-06-22 | 成都大学 | Chinese herbal medicine bacteriostatic effervescent tablet containing ligusticum wallichii extract and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1803187A (en) * | 2005-08-11 | 2006-07-19 | 葛小平 | Chinese herbal medicine for treating lumbar intervertebral disk protrusion and hyperosteogeny |
| CN1966057A (en) * | 2006-11-02 | 2007-05-23 | 张新成 | Externally applied Chinese medicinal liquid for preventing and treating chilblain |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1803187A (en) * | 2005-08-11 | 2006-07-19 | 葛小平 | Chinese herbal medicine for treating lumbar intervertebral disk protrusion and hyperosteogeny |
| CN1966057A (en) * | 2006-11-02 | 2007-05-23 | 张新成 | Externally applied Chinese medicinal liquid for preventing and treating chilblain |
Non-Patent Citations (1)
| Title |
|---|
| 曾冲等.治疗冻疮验方.<<求医问药>>.2003,23. * |
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Effective date of registration: 20130820 Address after: 226132, three Bridge Road, Yue Yue Industrial Zone, Haimen, Jiangsu, Nantong 188, China Patentee after: JIANGSU HANCHEN PHARMACEUTICAL Co.,Ltd. Address before: 523000, 503, room 1, Peony Pavilion, Dongcheng business garden, Dongguan, Guangdong, Dongcheng District Patentee before: Zhu Fengyi |
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Owner name: NANTONG TONGZHOU PINGCHAO PINGXI HEALTH CENTER Free format text: FORMER OWNER: JIANGSU HANCHEN PHARMACEUTICAL CO., LTD. Effective date: 20130911 |
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Free format text: CORRECT: ADDRESS; FROM: 226132 NANTONG, JIANGSU PROVINCE TO: 226361 NANTONG, JIANGSU PROVINCE |
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Effective date of registration: 20130911 Address after: Five Tongzhou District 226361 Jiangsu province Chao Ping Town, Nantong City three Guan Dian Patentee after: Nantong City, Tongzhou District Ping Pingchao town hospitals Address before: 226132, three Bridge Road, Yue Yue Industrial Zone, Haimen, Jiangsu, Nantong 188, China Patentee before: JIANGSU HANCHEN PHARMACEUTICAL Co.,Ltd. |
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Address after: No.8, Jiankang Road, Pingchao Town, Tongzhou District, Nantong City, Jiangsu Province, 226300 Patentee after: Pingchao health center, Pingchao Town, Tongzhou District, Nantong City Address before: No.8, Jiankang Road, Pingchao Town, Tongzhou District, Nantong City, Jiangsu Province, 226300 Patentee before: Nantong Tongzhou Pingchao Town Health Center |
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Address after: No.8, Jiankang Road, Pingchao Town, Tongzhou District, Nantong City, Jiangsu Province, 226300 Patentee after: Nantong Tongzhou Pingchao Town Health Center Address before: Group 5, Sanguandian village, Pingchao Town, Tongzhou District, Nantong City, Jiangsu Province Patentee before: Nantong City, Tongzhou District Ping Pingchao town hospitals |