CN102247446A - Composite whitening and spot correcting lotion and manufacturing method thereof - Google Patents

Composite whitening and spot correcting lotion and manufacturing method thereof Download PDF

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CN102247446A
CN102247446A CN 201110233407 CN201110233407A CN102247446A CN 102247446 A CN102247446 A CN 102247446A CN 201110233407 CN201110233407 CN 201110233407 CN 201110233407 A CN201110233407 A CN 201110233407A CN 102247446 A CN102247446 A CN 102247446A
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chinese medicine
active site
medicine active
raw material
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CN102247446B (en
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胡兴国
罗艳萍
刘畅
李丰
孙永
孟祥艳
张凯
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Guangzhou Huanya Cosmetic Science and Technology Co Ltd
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Guangzhou Huanya Cosmetic Science and Technology Co Ltd
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Abstract

The invention specifically discloses a composite whitening and spot correcting lotion, and a manufacturing method thereof. The spot correcting lotion is manufactured from raw materials of, by weight: 2.5 to 25 parts of traditional Chinese medicine active site extracts, 0.5 to 5 parts of arbutin, 0.05 to 0.2 parts of sodium hyaluronate, 5 to 10 parts of soybean fermentation extract, 1 to 10 parts of 1,3-butylene glycol, 1 to 10 parts of propylene glycol, 0.2 to 0.8 parts of tween-80, 0.1 to 0.4 parts of methyl-p-hydroxybenzoate, 0.1 to 0.4 parts of propylparaben, 0.5 to 5 parts pf ethanol, and 33.2 to 89.05 of deionized water. The traditional Chinese medicine active site extracts comprise raw materials of, by weight: 5 to 15 parts of ginseng, 5 to 20 parts of mongolian milkvetch root, 5 to 25 parts of white peony root, 5 to 30 parts of licorice, and 5 to 35 parts of cottonrose hibiscus flower. According to the composite whitening and spot correcting lotion provided by the invention, a plurality of traditional Chinese medicine active components are added to whitening and spot correcting active substances, such that the activity of tyrosinase can be effectively inhibited, oxygen-derived free radicals can be removed with high efficiency, and melanin can be prevented from appearing. With the composite whitening and spot correcting lotion, various freckles and chloasma can be comprehensively and rapidly corrected. Also, the lotion brings no toxin or harm.

Description

Light speckle liquid of composite whitening and manufacture method
Technical field
The present invention relates to the light speckle liquid of a kind of composite whitening, be specifically related to light speckle liquid of a kind of composite whitening and preparation method thereof.
Background technology
Freckle, chloasma are a kind of common skin phenomenons that a large amount of melanin are uneven in the human body deposition distribution and be difficult to cure, and have had a strong impact on patient's mental health.
Chloasma is the widest to women's harm, and main reason is the female incretion imbalance, and stress is big, lacks the stimulation of vitamin and external chemicals in various diseases (hepatic and kidney function obstacle, gynaecopathia, diabetes) etc. and the body and causes.
Freckle is a kind of facial skin lesion that occurs in, and is mottled, or Semen Sesami shape brown or beige fleck.The position of preferably sending out is cheeks portion and nose bridge, also can generally send to entire face even cervical region, is one of the most common reason that influences face appearance.
Cause the external factor of freckle, chloasma mainly to be: ultraviolet excessively shines, life-time service inferior and contain hormones cosmetics etc.The main method that solves the problem of above-mentioned mottle is: remove free oxygen free radical in cortex and the body, the restraint of tyrosinase activity is regulated human endocrine and substance metabolism.
The product of whitening and speckle dispelling is a lot of in the market, and its contained whitening and speckle dispelling composition is main: arbutin, mercury compound, hydroquinone, vitamin C, vitamin A and derivant thereof, kojic acid, Azelaic Acid, tretinoin, kojic acid etc.There is following problem in these products: (1) can only be effective to some mottle, can only be effective as arbutin to chloasma, and invalid to freckle.(2) skin is existed stimulation and infringement, as the mercurous and easier systemic toxicity that causes of hydroquinones cosmetics.
Summary of the invention
In order to solve the problem that existing whitening and speckle dispelling product exists, the object of the invention is to provide light speckle liquid of comprehensive, the safe composite whitening of a kind of curative effect and preparation method thereof.
For achieving the above object, technical scheme that the present invention adopts is as follows:
A kind of compound light speckle liquid, its raw material weight umber is:
Chinese medicine active site extract 2.5-25, arbutin 0.5-5, hyaluronate sodium 0.05-0.2, fermented soybean extracting solution 5-10,1,3 butylene glycol 1-10, propylene glycol 1-10, tween 80 0.2-0.8, methyl hydroxybenzoate 0.1-0.4, propylparaben 0.1-0.4, ethanol 0.5-5 and deionized water 33.2-89.05; Wherein, the raw material weight umber of described Chinese medicine active site extract is: Radix Ginseng 5-15, Radix Astragali 5-20, Radix Paeoniae Alba 5-25, Radix Glycyrrhizae 5-30, Flos Hibisci Mutabilis 5-35.
Preferably, described compound light speckle liquid raw materials in part by weight is:
Chinese medicine active site extract 20, arbutin 5, hyaluronate sodium 0.1, fermented soybean extracting solution 5,1,3 butylene glycol 5, propylene glycol 3, tween 80 0.4, methyl hydroxybenzoate 0.2, propylparaben 0.1, ethanol 4, deionized water 57.2; Wherein, the raw material weight umber of described Chinese medicine active site extract is: Radix Ginseng 5, the Radix Astragali 10, the Radix Paeoniae Alba 20, Radix Glycyrrhizae 10, Flos Hibisci Mutabilis 10.
A kind of manufacture method of FUHE MEIBAI QUBAN YE may further comprise the steps:
(1) method for extraction and purification of Chinese medicine active site extract is:
It is in 30%~85% ethanol that the Chinese medicine active site extract raw material of Radix Ginseng 5-15 part, Radix Astragali 5-20 part, Radix Paeoniae Alba 5-25 part, Radix Glycyrrhizae 5-30 part and Flos Hibisci Mutabilis 5-35 part is soaked in concentration according to 1: 5 to 1: 10 medicine and solvent ratios, and soak time is 24-96 hour;
Filter then, with filtrate in 50 ℃ of-80 ℃ of decompression recycling ethanols after do not have the alcohol flavor, add 2-5 times of water gaging dilution, the macroporous resin column that goes up the resin model again and be D101 or AB-8 wash colourless after, reuse 20%-80% ethanol elution is colourless to eluent, and the collection ethanol elution, be 1: 2~1: 10 in 50 ℃ of-80 ℃ of decompression recycling ethanols to medicinal liquid with the medical material ratio again, make Chinese medicine active site extract;
(2) with described Chinese medicine active site extract 2.5-25 part, arbutin 0.5-5 part, hyaluronate sodium 0.05-0.2 part, 1,3-butanediol 1-10 part, propylene glycol 1-10 part and fermented soybean extracting solution 5-10 part join in 20-40 part deionized water, in reinforced process, stir, and finish restir 10-20 minute afterwards reinforced while feeding in raw material;
(3) add the mixture of methyl hydroxybenzoate 0.1-0.4 part, tween 80 0.2-0.8 part, propylparaben 0.1-0.4 part and ethanol 0.5-5 part again, add deionized water to total amount again and reach 100 parts, and stir;
(4) ultraviolet disinfection 40-60 minute, left standstill 6-48 hour, supernatant gets product.
Preferably, in the manufacture method of the light speckle liquid of described composite whitening: also comprise the step that described Chinese medicine active site extract raw material powder is broken into coarse powder before in described step (1).
Preferably, in the manufacture method of the light speckle liquid of described composite whitening: the concentration of alcohol that being used in the described step (1) soaked Chinese medicine active site extract raw material is 60%, described Chinese medicine active site extract raw material and proportion of ethanol are 1: 8, and described soak time is 48 hours.
Preferably, in the manufacture method of the light speckle liquid of described composite whitening: the concentration of alcohol that is used for eluting in the described step (1) is 70%.The FUHE MEIBAI QUBAN YE outward appearance of the present invention's preparation is that light yellow clear liquid arrives brown translucent liquid, and abnormal smells from the patient is slight, and pH value is 5.0~7.0, and the product of gained of the present invention should seal and be stored in 15~25 ℃ of dry lucifuge environment in cool place.
The FUHE MEIBAI QUBAN YE of the present invention preparation can directly add and directly is applied in the mottle position after deionized water is diluted to the water preparation that contains complex liquid 0.01-99%, also can be added to by the addition of 0.01-20% in cream frost, essence, the emulsion.
The FUHE MEIBAI QUBAN YE of the present invention's preparation is the combination of plurality of Chinese composition and whitening and speckle dispelling active component.Wherein, Radix Ginseng extract can effectively hinder melanic biosynthesis, has very strong anti-oxidation function simultaneously; Radix Astragali extract has nourishes rough skin and anti-aging effects; Radix Glycyrrhizae contains compositions such as licoflavone, has very strong restraint of tyrosinase active function, effectively prevents melanic generation and over-deposit, simultaneously can also decompose, reduce the melanin that forms in skin effectively; The Radix Paeoniae Alba, Flos Hibisci Mutabilis have the activity of extremely strong restraint of tyrosinase, can effectively suppress melanic generation, the melanin that desalination has formed; Arbutin has the active function of stronger restraint of tyrosinase, is the higher whitening agent of safety in the modern cosmetics; Hyaluronic acid has stronger moisture of skin and repair function.The fermented soybean extracting solution is rich in compositions such as soybean isoflavone, aminoacid, has good restraining tyrosinase activity and moisture-keeping functions.
Composite whitening of the present invention is used the theory of the combination of Chinese and Western medicine by spot-dispelling liquid, in the whitening and speckle dispelling active matter, added the plurality of Chinese active component, by active ingredient of Chinese herbs and the collaborative mutually effect of other whitening and speckle dispelling active matter, energy is the activity of restraint of tyrosinase effectively, the efficient oxygen-derived free radicals of removing, prevent melanic generation, decompose the melanin that desalination has formed, can regulate simultaneously the hormonal system of human body, repair the damage that skin is caused owing to chemical constituents such as hormones, thereby reach effect quick comprehensively, treating both the principal and secondary aspects of a disease.FUHE MEIBAI QUBAN YE of the present invention does not contain the human body poisonous and harmful substance, is a kind of product safely and effectively.
Therefore, composite whitening of the present invention has been added the plurality of Chinese active component by spot-dispelling liquid in the whitening and speckle dispelling active matter, energy is the activity of restraint of tyrosinase effectively, the efficient oxygen-derived free radicals of removing, prevent melanic generation, not only can desalinate various freckles and chloasma fast comprehensively, and nontoxic.
The specific embodiment
Describe the present invention in detail below in conjunction with specific implementation method, be used for explaining the present invention in schematic enforcement of the present invention and explanation, but not as a limitation of the invention.
Embodiment 1:
Present embodiment discloses prescription of the light speckle liquid of a kind of composite whitening and preparation method thereof, and the raw material umber in its composition of raw materials is:
Chinese medicine active site extract 2.5, arbutin 0.5, hyaluronate sodium 0.05, fermented soybean extracting solution 5,1,3 butylene glycol 1, propylene glycol 1, tween 80 0.2, methyl hydroxybenzoate 0.1, propylparaben 0.1, ethanol 0.5 and deionized water 89.05; Wherein, the raw material weight umber of described Chinese medicine active site extract is: Radix Ginseng 5, the Radix Astragali 5, the Radix Paeoniae Alba 5, Radix Glycyrrhizae 5, Flos Hibisci Mutabilis 5.The FUHE MEIBAI QUBAN YE manufacture method of present embodiment is achieved in that
(1) method for extraction and purification of Chinese medicine active site extract is: with parts by weight be: the raw material mixed powder of Radix Ginseng 5, the Radix Astragali 5, the Radix Paeoniae Alba 5, Radix Glycyrrhizae 5, Flos Hibisci Mutabilis 5 is broken into coarse powder, being soaked in concentration according to medicated powder and 1: 5 ratio of solvent is in 30% ethanol, and soak time is 24 hours;
Filter then, with filtrate in 50 ℃ of decompression recycling ethanols after do not have the alcohol flavor, add 2 times of water gaging dilutions, the macroporous resin column that goes up the resin model again and be D101 wash colourless after, reuse 20% ethanol elution is colourless to eluent, and the collection ethanol elution, be 1: 2~1: 10 in 50 ℃ of decompression recycling ethanols to medicinal liquid with the medical material ratio again, make Chinese medicine active site extract;
(2) with 0.05 part of 2.5 parts of above-mentioned Chinese medicine active site extract, 0.5 part of arbutin, hyaluronate sodium, 1,1 part of 3-butanediol, 1 part of propylene glycol and fermented soybean extracting solution join in 20 parts of deionized waters for 5 parts, in reinforced process, stir while feed in raw material, and at the end restir 10 minutes afterwards that feeds in raw material;
(3) add the mixture of 0.5 part of 0.1 part of methyl hydroxybenzoate, 0.2 part of tween 80,0.1 part of propylparaben and ethanol again, add 69.05 parts of deionized waters again, make total amount reach 100 parts, and stir;
(4) ultraviolet disinfection is 40 minutes, leaves standstill 6 hours, and supernatant gets product.
Embodiment 2:
The present embodiment raw materials in part by weight is:
Chinese medicine active site extract 5, arbutin 5, hyaluronate sodium 0.1, fermented soybean extracting solution 5,1,3 butylene glycol 5, propylene glycol 3, tween 80 0.4, methyl hydroxybenzoate 0.2, propylparaben 0.1, ethanol 4, deionized water 72.2; Wherein, the raw material weight umber of described Chinese medicine active site extract is: Radix Ginseng 5, the Radix Astragali 10, the Radix Paeoniae Alba 20, Radix Glycyrrhizae 10, Flos Hibisci Mutabilis 10.The manufacture method of the described invention of the embodiment of the invention is substantially the same manner as Example 1, and difference also comprises except raw materials in part by weight:
The concentration of alcohol that is used to soak medicated powder in the described step (1) is 60%, and described Chinese medicine active site extract raw material and proportion of ethanol are 1: 8, and described soak time is 48 hours, and the described concentration of alcohol that is used for eluting is 70%.
Embodiment 3
The present embodiment raw materials in part by weight is:
Chinese medicine active site 8, arbutin 2, hyaluronate sodium 0.1,1,3 butylene glycol 5, propylene glycol 3, fermented soybean extracting solution 10, methyl hydroxybenzoate 0.2, propylparaben 0.2, tween 80 0.4, ethanol 2, deionized water 69.1.Wherein, described Chinese medicine extract raw material weight umber is: Radix Ginseng 10, the Radix Astragali 10, the Radix Paeoniae Alba 20, Radix Glycyrrhizae 20, Flos Hibisci Mutabilis 20.
The manufacture method of the described invention of the embodiment of the invention is substantially the same manner as Example 1, and is different except raw materials in part by weight, only is that the concentration of alcohol that soaks medicated powder is 55%, and soak time is 48 hours.The macroporous resin model is AB-8 during purification, and the concentration of alcohol of eluting macroporous resin column is 70%.
Embodiment 4:
The present embodiment raw materials in part by weight is:
Chinese medicine active site extract 25, arbutin 5, hyaluronate sodium 0.2, fermented soybean extracting solution 10,1,3 butylene glycol 10, propylene glycol 10, tween 80 0.8, methyl hydroxybenzoate 0.4, propylparaben 0.4, ethanol 5 and deionized water 33.2; Wherein, the raw material weight umber of described Chinese medicine active site extract is: Radix Ginseng 15, the Radix Astragali 20, the Radix Paeoniae Alba 25, Radix Glycyrrhizae 30, Flos Hibisci Mutabilis 35.The FUHE MEIBAI QUBAN YE manufacture method of present embodiment is achieved in that
It is in 85% ethanol that the Chinese medicine active site extract raw material of 35 parts of 15 parts of Radix Ginsengs, 20 parts of the Radixs Astragali, 25 parts of the Radix Paeoniae Albas, 30 parts in Radix Glycyrrhizae and Flos Hibisci Mutabilis is soaked in concentration according to 1: 10 medicine and solvent ratios, and soak time is 96 hours;
Filter then, with filtrate in 80 ℃ of decompression recycling ethanols after do not have the alcohol flavor, add 5 times of water gaging dilutions, the macroporous resin column that goes up the resin model again and be D101 wash colourless after, reuse 80% ethanol elution is colourless to eluent, and the collection ethanol elution, be 1: 5 in 80 ℃ of decompression recycling ethanols to medicinal liquid with the medical material ratio again, make Chinese medicine active site extract;
(2) with 0.2 part of 25 parts of described Chinese medicine active site extract, 5 parts of arbutin, hyaluronate sodium, 1,10 parts of 3-butanediols, 10 parts of propylene glycol and fermented soybean extracting solution join in 20 parts of deionized waters for 10 parts, in reinforced process, stir while feed in raw material, and at the end restir 20 minutes afterwards that feeds in raw material;
(3) add the mixture of 5 parts of 0.4 part of methyl hydroxybenzoate, 0.8 part of tween 80,0.4 part of propylparaben and ethanol again, add deionized water to total amount again and reach 100 parts, and stir;
(4) ultraviolet disinfection is 60 minutes, leaves standstill 48 hours, and supernatant gets product.
Methyl hydroxybenzoate and propylparaben are antiseptic among the present invention, and both are composite to have the excellent prevention growth of microorganism; Ethanol and tween 80 are solubilizing agent.Wherein, the concentration of alcohol the best during extraction is 60%, and this concentration ethanol can be extracted each active component of Chinese medicine in the prescription to greatest extent, comprises the effective ingredient of water solublity and pure dissolubility.Through experimentation relatively, it is 1: 8 that each Chinese crude drug is ground into coarse powder interpolation proportion of ethanol, and soak time is 72 hours, and extracts active ingredients is more complete, and impurity is less, eluting macroporous resin concentration of alcohol is 70%, and extracting solution has been removed impurity such as starch, pectin through behind the purification by macroporous resin, improved active matter content, make product more stable, best results is than being more suitable for skin.
The test of vitro inhibition tryrosinase
Experimental technique
Experiment material
L-tyrosine solution (0.5mg/mL), tryrosinase (100U/ml), the light speckle liquid of composite whitening.
2, instrument:
The 10ml test tube, water-bath, agitator, ultraviolet spectrometry degree meter.
3, test method:
1. the light speckle liquid of embodiment 4 gained composite whitenings is added deionized water and be diluted to 0.1%, 0.2%, 0.4%, 0.6%, 0.8%, 1% solution is pressed the restraint of tyrosinase activity that literature method is measured diluent.The document is: " the enzyme microb whitening anti-aging efficacy study " that appoint clearly, Yu Xiaoyan etc. delivered in 2008 03 phases " fragrance flavor and cosmetic ";
4, experimental result
Whitening, spot liquid restraint of tyrosinase measurement result
Figure BSA00000556888700071
Figure BSA00000556888700081
More than the technical scheme that the embodiment of the invention provided is described in detail, used specific case herein the principle and the embodiment of the embodiment of the invention are set forth, the explanation of above embodiment only is applicable to the principle that helps to understand the embodiment of the invention; Simultaneously, for one of ordinary skill in the art, according to the embodiment of the invention, the part that on the specific embodiment and range of application, all can change, in sum, this description should not be construed as limitation of the present invention.

Claims (6)

1. compound light speckle liquid is characterized in that its raw material weight umber is:
Chinese medicine active site extract 2.5-25, arbutin 0.5-5, hyaluronate sodium 0.05-0.2, fermented soybean extracting solution 5-10,1,3 butylene glycol 1-10, propylene glycol 1-10, tween 80 0.2-0.8, methyl hydroxybenzoate 0.1-0.4, propylparaben 0.1-0.4, ethanol 0.5-5 and deionized water 33.2-89.05;
Wherein, the raw material weight umber of described Chinese medicine active site extract is:
Radix Ginseng 5-15, Radix Astragali 5-20, Radix Paeoniae Alba 5-25, Radix Glycyrrhizae 5-30, Flos Hibisci Mutabilis 5-35.
2. compound light speckle liquid according to claim 1 is characterized in that its raw materials in part by weight is:
Chinese medicine active site extract 20, arbutin 5, hyaluronate sodium 0.1, fermented soybean extracting solution 5,1,3 butylene glycol 5, propylene glycol 3, tween 80 0.4, methyl hydroxybenzoate 0.2, propylparaben 0.1, ethanol 4, deionized water 57.2;
Wherein, the raw material weight umber of described Chinese medicine active site extract is:
Radix Ginseng 5, the Radix Astragali 10, the Radix Paeoniae Alba 20, Radix Glycyrrhizae 10, Flos Hibisci Mutabilis 10.
3. the manufacture method of a FUHE MEIBAI QUBAN YE is characterized in that may further comprise the steps:
(1) method for extraction and purification of Chinese medicine active site extract is:
It is in 30%~85% ethanol that the Chinese medicine active site extract raw material of Radix Ginseng 5-15 part, Radix Astragali 5-20 part, Radix Paeoniae Alba 5-25 part, Radix Glycyrrhizae 5-30 part and Flos Hibisci Mutabilis 5-35 part is soaked in concentration according to 1: 5 to 1: 10 medicine and solvent ratios, and soak time is 24-96 hour;
Filter then, with filtrate in 50 ℃ of-80 ℃ of decompression recycling ethanols after do not have the alcohol flavor, add 2-5 times of water gaging dilution, the macroporous resin column that goes up the resin model again and be D101 or AB-8 wash colourless after, reuse 20%-80% ethanol elution is colourless to eluent, and the collection ethanol elution, be 1: 2~1: 10 in 50 ℃ of-80 ℃ of decompression recycling ethanols to medicinal liquid with the medical material ratio again, make Chinese medicine active site extract;
(2) with described Chinese medicine active site extract 2.5-25 part, arbutin 0.5-5 part, hyaluronate sodium 0.05-0.2 part, 1,3-butanediol 1-10 part, propylene glycol 1-10 part and fermented soybean extracting solution 5-10 part join in 20-40 part deionized water, in reinforced process, stir, and finish restir 10-20 minute afterwards reinforced while feeding in raw material;
(3) add the mixture of methyl hydroxybenzoate 0.1-0.4 part, tween 80 0.2-0.8 part, propylparaben 0.1-0.4 part and ethanol 0.5-5 part again, add deionized water to total amount again and reach 100 parts, and stir;
(4) ultraviolet disinfection 40-60 minute, left standstill 6-48 hour, get supernatant and get product.
4. as the manufacture method of the light speckle liquid of claim 3 composite whitening, it is characterized in that:
Also comprise the step that described Chinese medicine active site extract raw material powder is broken into coarse powder before in described step (1).
5. get manufacture method according to claim 3 or 4 described FUHE MEIBAI QUBAN YE, it is characterized in that:
The concentration of alcohol that being used in the described step (1) soaked Chinese medicine active site extract raw material is 60%, and described Chinese medicine active site extract raw material and proportion of ethanol are 1: 8, and described soak time is 48 hours.
6. get manufacture method according to claim 3 or 4 described FUHE MEIBAI QUBAN YE, it is characterized in that:
The concentration of alcohol that is used for eluting in the described step (1) is 70%.
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CN102631310A (en) * 2012-04-19 2012-08-15 扬州十二粉黛生物工程有限公司 Peach blossom water solution
CN102972591A (en) * 2012-11-27 2013-03-20 启东市大华电动工具有限公司 Skin whitening milky tea
CN104586737A (en) * 2015-01-08 2015-05-06 上海圣婕化妆品有限公司 Probiotic whitening recovery mask essence and preparation method thereof
CN105125436A (en) * 2015-08-18 2015-12-09 广东轻工职业技术学院 Compound whitening composition and preparation method
CN105168040A (en) * 2015-08-18 2015-12-23 广东轻工职业技术学院 Composite anti-ageing skin-care composition and manufacturing method
CN105342916A (en) * 2015-11-19 2016-02-24 伽蓝(集团)股份有限公司 Plant extract product composition, and preparation method and application thereof
CN107951739A (en) * 2017-12-31 2018-04-24 山东禹泽医药科技有限公司 A kind of small peptide combinations of chicken embryo with white-skinned face function
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CN111920699A (en) * 2020-09-14 2020-11-13 广州新济薇娜生物科技有限公司 Whitening and freckle-removing composition, whitening and freckle-removing soluble microneedle patch and preparation method thereof
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CN102441078A (en) * 2011-12-06 2012-05-09 董莉霞 Medicinal composition with freckle removing function and preparation method thereof
CN102631310A (en) * 2012-04-19 2012-08-15 扬州十二粉黛生物工程有限公司 Peach blossom water solution
CN102972591A (en) * 2012-11-27 2013-03-20 启东市大华电动工具有限公司 Skin whitening milky tea
CN104586737A (en) * 2015-01-08 2015-05-06 上海圣婕化妆品有限公司 Probiotic whitening recovery mask essence and preparation method thereof
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CN105168040A (en) * 2015-08-18 2015-12-23 广东轻工职业技术学院 Composite anti-ageing skin-care composition and manufacturing method
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CN105342916A (en) * 2015-11-19 2016-02-24 伽蓝(集团)股份有限公司 Plant extract product composition, and preparation method and application thereof
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