CN102246819A - Instant chlorine dioxide effervescent tablet and preparation method thereof - Google Patents
Instant chlorine dioxide effervescent tablet and preparation method thereof Download PDFInfo
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- CN102246819A CN102246819A CN2011101305751A CN201110130575A CN102246819A CN 102246819 A CN102246819 A CN 102246819A CN 2011101305751 A CN2011101305751 A CN 2011101305751A CN 201110130575 A CN201110130575 A CN 201110130575A CN 102246819 A CN102246819 A CN 102246819A
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- chlorine dioxide
- effervescent tablet
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Abstract
The invention discloses an instant chlorine dioxide effervescent tablet and a preparation method thereof. The instant chlorine dioxide effervescent tablet comprises the following components in by weight percent: 30-40% of chlorite, 40-50% of acidifier, 10-15% of effervescing agent, 1-10% of release agent, 1-2% of lubricant and 1-5% of catalyst. The preparation method of the instant chlorine dioxide effervescent tablet comprises the following steps: (1) drying the materials; (2) mixing the powder materials; and (3) tabletting. The instant chlorine dioxide effervescent tablet disclosed in the invention has the beneficial effects that: the instant chlorine dioxide effervescent tablet can be completely dissolved in water within 2 minutes so as to form a high-purity chlorine dioxide solution; when being used, the instant chlorine dioxide effervescent tablet is not influenced by the pH value and temperature of water, and no residues are generated after the instant chlorine dioxide effervescent tablet is dissolved; and the instant chlorine dioxide effervescent tablet has the advantages of simple preparation process and low preparation cost.
Description
Technical field
The present invention relates to a kind of instant chlorine dioxide effervescent tablet and preparation method thereof.
Background technology
Chlorine dioxide is a new generation's safety of generally acknowledging in the world at present, efficient, the sterilization of wide spectrum, fresh-keeping and deodorant, be desirable chlorinated product substitute, in developed country, be widely used in the anti-corrosive fresh-keeping etc. of sterilization, deodorizing, mildew-resistant and the food of food and food processing industry, aquaculture, pharmacy industry, hospital, public environment etc.The World Health Organization (WHO) has classified chlorine dioxide as A1 level security high effect disinfectants.China Ministry of Public Health also approved chlorine dioxide is disinfectant and new food additive.
Chlorine dioxide normal temperature is gas down, and is very unstable, runs into reduction material just to react, and decomposes behind the chance light, so chlorine dioxide generally all is on-the-spot generation, uses up as early as possible.
The method great majority that prepare at present chlorine dioxide all are to use binary chlorine dioxide or chlorine dioxide effervescent tablet, the binary chlorine dioxide is about to two kinds of solution and is contained in respectively in two bottles, being about to two kinds of solution during use mixes and obtains chlorine dioxide, two kinds of solution can be sodium chlorite and hydrochloric acid or sodium chlorate and concentrated hydrochloric acid, but the packaging volume of this quadrat method is excessive, carry inconvenience, need equipment to add simultaneously, and the chlorine dioxide that generates is difficult for metering.
Effervescent tablet is a kind of tablet that sour agent and the alkaline agent that can produce carbonic acid gas are formed, and when running into water, neutralization reaction takes place, and discharges carbon dioxide (effervescence), the solid pharmaceutical preparation that makes rapid disintegration of tablet and dissolving.The production of effervescent tablet, transportation, storage are solid forms, the dosage with solid pharmaceutical preparation accurately, steady quality, production automation degree height, characteristics such as easy to carry.Chlorine dioxide effervescent tablet is exactly a characteristic of utilizing effervescent tablet, remove activation act loaded down with trivial details, that stimulate from, guarantee that simultaneously active ingredient all is dissolved in the water, can produce quantitative highly purified ClO 2 solution, but present chlorine dioxide effervescent tablet dissolution velocity is not very fast, dissolving neither be very complete, when utilizations such as some crucial places such as hospital ward, operating room, tends to because a few minutes of delaying produce very big trouble.
Summary of the invention
Goal of the invention of the present invention is to solve the deficiencies in the prior art, a kind of instant chlorine dioxide effervescent tablet and preparation method thereof is provided, can be fast, generation chlorine dioxide soluble in water fully, be not subjected to the pH value and the Temperature Influence of water during use, the no residue in dissolving back, but also have the advantages that preparation process is succinct, preparation cost is cheap.
Goal of the invention of the present invention is achieved through the following technical solutions: instant chlorine dioxide effervescent tablet, and it comprises following components in part by weight:
Chlorite 40 acidulants 40
Effervescent agent 15 interleaving agents 1
Lubricant 2 catalyzer 2.
Described chlorite is a sodium chlorite, and acidulant is a niter cake, and interleaving agent is an anhydrous magnesium sulfate, and lubricant is a sodium carboxymethylcellulose, and catalyzer is a DCCNa.
Described effervescent agent is made up of by the weight ratio of 1:1 acidulant and alkaline agent, and described alkaline agent is a sodium bicarbonate, and its fineness is 60～100 orders, need before the preparation effervescent agent 60～80 ℃ dry 2～4 hours down.
The preparation method of instant chlorine dioxide effervescent tablet, it may further comprise the steps:
(1) drying materials: formula material was smoked under 75 ℃ 24 hours;
(2) powder mixes: formula material is sieved on request, take by weighing each recipe ingredient then in proportion, in general mixing apparatus, add chlorite, effervescent agent alkaline agent and magnesium sulfate, add acidulant, lubricant and catalyzer behind the mixing again, mixed 10 minutes, and made to mix;
(3) compressing tablet: 15 ~ 25 ℃ of temperature, under the environment of relative moisture 20 ~ 40%, mixture compression moulding on tablet press machine of using punch die that step (2) is obtained.
The invention has the beneficial effects as follows: placing water is that solubilized is intact in 2 minutes, forms highly purified ClO 2 solution, is not subjected to the pH value and the Temperature Influence of water during use, the no residue in dissolving back, but also have the advantage that preparation process is succinct, preparation cost is cheap.
Embodiment
Further specify technical scheme of the present invention below in conjunction with specific embodiment:
[embodiment 1]
Instant chlorine dioxide effervescent tablet, it comprises following components in part by weight:
Chlorite 40 acidulants 40
Effervescent agent 15 interleaving agents 1
Lubricant 2 catalyzer 2.
Described chlorite is a sodium chlorite, acidulant is a niter cake, and interleaving agent is an anhydrous magnesium sulfate, and its Powdered characteristic and good flowing property are effectively isolated sodium chlorite and acidulant, lubricant is a sodium carboxymethylcellulose, and catalyzer is a DCCNa.
Described effervescent agent is made up of by the weight ratio of 1:1 acidulant and alkaline agent, used alkaline agent is a sodium bicarbonate, niter cake and sodium bicarbonate enter in the water can produce carbonic acid gas after the reaction, make this effervescent tablet dissolve rapidly, the fineness of the sodium bicarbonate of selecting for use is 60 orders, need before the preparation effervescent agent 60 ℃ dry 4 hours down.
Chlorine dioxide then is that sodium chlorite and acidulant are that the niter cake effect generates, and dissolves in to obtain being used for the ClO 2 solution of sterilization in the water.
The preparation method of instant chlorine dioxide effervescent tablet, it may further comprise the steps:
(1) drying materials: formula material was smoked under 75 ℃ 24 hours;
(2) powder mixes: formula material is sieved on request, take by weighing each recipe ingredient then in proportion, in general mixing apparatus, add chlorite, effervescent agent alkaline agent and magnesium sulfate, add acidulant, lubricant and catalyzer behind the mixing again, mixed 10 minutes, and made to mix;
(3) compressing tablet: 15 ℃ of temperature, under the environment of relative moisture 20%, use the punch die of 1.0 centimetres of diameters, with mixture compression moulding on tablet press machine that step (2) obtains, every heavy 0.5 gram.
After the chlorine dioxide effervescent tablet of present embodiment is put into water, dissolved in 2 minutes, formed the yellow green clear solution, this solution is chlorine dioxide with high purity solution.
[embodiment 2]
Instant chlorine dioxide effervescent tablet, it comprises following components in part by weight:
Chlorite 40 acidulants 40
Effervescent agent 15 interleaving agents 1
Lubricant 2 catalyzer 2.
Described chlorite is a sodium chlorite; Described acidulant is a niter cake; Described interleaving agent is an anhydrous magnesium sulfate, and its Powdered characteristic and good flowing property are effectively isolated sodium chlorite and acidulant; Described lubricant is a sodium carboxymethylcellulose; Described catalyzer is a DCCNa.
Described effervescent agent is made up of by the weight ratio of 1:1 acidulant and alkaline agent, used alkaline agent is a sodium bicarbonate, niter cake and sodium bicarbonate enter in the water can produce carbonic acid gas after the reaction, make this effervescent tablet dissolve rapidly, the fineness of the sodium bicarbonate of selecting for use is 70 orders, need before the preparation effervescent agent 80 ℃ dry 3 hours down.
Chlorine dioxide then is that sodium chlorite and acidulant are that the niter cake effect generates, and dissolves in to obtain being used for the ClO 2 solution of sterilization in the water.
The preparation method of instant chlorine dioxide effervescent tablet, it may further comprise the steps:
(1) drying materials: formula material was smoked under 75 ℃ 24 hours;
(2) powder mixes: formula material is sieved on request, take by weighing each recipe ingredient then in proportion, in general mixing apparatus, add chlorite, effervescent agent alkaline agent and magnesium sulfate, add acidulant, lubricant and catalyzer behind the mixing again, mixed 10 minutes, and made to mix;
(3) compressing tablet: 25 ℃ of temperature, under the environment of relative moisture 40%, use the punch die of 2.0 centimetres of diameters, with mixture compression moulding on tablet press machine that step (2) obtains, every heavy 1.0 grams.
After the chlorine dioxide effervescent tablet of present embodiment is put into water, dissolved in 2 minutes, formed the yellow green clear solution, this solution is chlorine dioxide with high purity solution.
[embodiment 3]
Instant chlorine dioxide effervescent tablet, it comprises following components in part by weight:
Chlorite 40 acidulants 40
Effervescent agent 15 interleaving agents 1
Lubricant 2 catalyzer 2.
Described chlorite is a sodium chlorite; Described acidulant is a niter cake; Described interleaving agent is an anhydrous magnesium sulfate, and its Powdered characteristic and good flowing property are effectively isolated sodium chlorite and acidulant; Described lubricant is a sodium carboxymethylcellulose; Described catalyzer is a DCCNa.
Described effervescent agent is made up of by the weight ratio of 1:1 acidulant and alkaline agent, used alkaline agent is a sodium bicarbonate, niter cake and sodium bicarbonate enter in the water can produce carbonic acid gas after the reaction, make this effervescent tablet dissolve rapidly, the fineness of the sodium bicarbonate of selecting for use is 80 orders, need before the preparation effervescent agent 70 ℃ dry 2 hours down.
Chlorine dioxide then is that sodium chlorite and acidulant are that the niter cake effect generates, and dissolves in to obtain being used for the ClO 2 solution of sterilization in the water.
The preparation method of instant chlorine dioxide effervescent tablet, it may further comprise the steps:
(1) drying materials: formula material was smoked under 75 ℃ 24 hours;
(2) powder mixes: formula material is sieved on request, take by weighing each recipe ingredient then in proportion, in general mixing apparatus, add chlorite, effervescent agent alkaline agent and magnesium sulfate, add acidulant, lubricant and catalyzer behind the mixing again, mixed 10 minutes, and made to mix;
(3) compressing tablet: 20 ℃ of temperature, under the environment of relative moisture 30%, use the punch die of 2.0 centimetres of diameters, with mixture compression moulding on tablet press machine that step (2) obtains, every heavy 1.0 grams.
After the chlorine dioxide effervescent tablet of present embodiment is put into water, dissolved in 2 minutes, formed the yellow green clear solution, this solution is chlorine dioxide with high purity solution.
[embodiment 4]
Instant chlorine dioxide effervescent tablet, it comprises following components in part by weight:
Chlorite 40 acidulants 40
Effervescent agent 15 interleaving agents 1
Lubricant 2 catalyzer 2.
Described chlorite is a sodium chlorite; Described acidulant is a niter cake; Described interleaving agent is an anhydrous magnesium sulfate, and its Powdered characteristic and good flowing property are effectively isolated sodium chlorite and acidulant; Described lubricant is a sodium carboxymethylcellulose; Described catalyzer is a DCCNa.
Described effervescent agent is made up of by the weight ratio of 1:1 acidulant and alkaline agent, used alkaline agent is a sodium bicarbonate, niter cake and sodium bicarbonate enter in the water can produce carbonic acid gas after the reaction, make this effervescent tablet dissolve rapidly, the fineness of the sodium bicarbonate of selecting for use is 80 orders, need before the preparation effervescent agent 80 ℃ dry 2 hours down.
Chlorine dioxide then is that sodium chlorite and acidulant are that the niter cake effect generates, and dissolves in to obtain being used for the ClO 2 solution of sterilization in the water.
The preparation method of instant chlorine dioxide effervescent tablet, it may further comprise the steps:
(1) drying materials: formula material was smoked under 75 ℃ 24 hours;
(2) powder mixes: formula material is sieved on request, take by weighing each recipe ingredient then in proportion, in general mixing apparatus, add chlorite, effervescent agent alkaline agent and magnesium sulfate, add acidulant, lubricant and catalyzer behind the mixing again, mixed 10 minutes, and made to mix;
(3) compressing tablet: 25 ℃ of temperature, under the environment of relative moisture 20%, use the punch die of 1.0 centimetres of diameters, with mixture compression moulding on tablet press machine that step (2) obtains, every heavy 0.5 gram.
After the chlorine dioxide effervescent tablet of present embodiment is put into water, dissolved in 2 minutes, formed the yellow green clear solution, this solution is chlorine dioxide with high purity solution.
When using, the present invention is not subjected to the pH value and the Temperature Influence of water, the no residue in dissolving back.
Claims (5)
1. instant chlorine dioxide effervescent tablet is characterized in that: it comprises following components in part by weight:
Chlorite 30～40 acidulants 40～50
Effervescent agent 10～15 interleaving agents 1～10
Lubricant 1～2 catalyzer 1～5.
2. instant chlorine dioxide effervescent tablet according to claim 1, it is characterized in that: described chlorite is a sodium chlorite, and acidulant is a niter cake, and interleaving agent is an anhydrous magnesium sulfate, lubricant is a sodium carboxymethylcellulose, and catalyzer is a DCCNa.
3. instant chlorine dioxide effervescent tablet according to claim 1 is characterized in that: described effervescent agent is made up of by the weight ratio of 1:1 acidulant and alkaline agent.
4. instant chlorine dioxide effervescent tablet according to claim 3 is characterized in that: described alkaline agent is a sodium bicarbonate, and its fineness is 60～100 orders.
5. the preparation method of instant chlorine dioxide effervescent tablet, it is characterized in that: it may further comprise the steps:
(1) drying materials: formula material was smoked under 75 ℃ 24 hours;
(2) powder mixes: formula material is sieved on request, take by weighing each recipe ingredient then in proportion, in general mixing apparatus, add chlorite, effervescent agent alkaline agent and magnesium sulfate, add acidulant, lubricant and catalyzer behind the mixing again, mixed 10 minutes, and made to mix;
(3) compressing tablet: 15 ~ 25 ℃ of temperature, under the environment of relative moisture 20 ~ 40%, mixture compression moulding on tablet press machine of using punch die that step (2) is obtained.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110130575 CN102246819B (en) | 2011-05-19 | 2011-05-19 | Instant chlorine dioxide effervescent tablet and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 201110130575 CN102246819B (en) | 2011-05-19 | 2011-05-19 | Instant chlorine dioxide effervescent tablet and preparation method thereof |
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| Publication Number | Publication Date |
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| CN102246819A true CN102246819A (en) | 2011-11-23 |
| CN102246819B CN102246819B (en) | 2013-12-18 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104138390A (en) * | 2014-06-11 | 2014-11-12 | 龚佳郎 | Chlorine dioxide effervescent tablet for killing barbier bacteria and fungi and preparation method thereof |
| CN105668730A (en) * | 2016-03-22 | 2016-06-15 | 江苏祥豪实业有限公司 | Novel chlorine dioxide material for treating water and method for preparing novel chlorine dioxide material |
| CN115777723A (en) * | 2023-02-07 | 2023-03-14 | 山东华实药业有限公司 | Instant chlorine dioxide effervescent tablet and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101228868A (en) * | 2008-02-27 | 2008-07-30 | 河北科技大学 | Unitary solid chlorine dioxide effervescent tablet and preparation method thereof |
| CN101658168A (en) * | 2009-09-11 | 2010-03-03 | 中国农业大学 | Effervescent tablet of plant growth regulator composition and preparation method thereof |
| CN101791319A (en) * | 2010-04-07 | 2010-08-04 | 北京欧凯纳斯科技有限公司 | Female pudendum nursing product |
-
2011
- 2011-05-19 CN CN 201110130575 patent/CN102246819B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101228868A (en) * | 2008-02-27 | 2008-07-30 | 河北科技大学 | Unitary solid chlorine dioxide effervescent tablet and preparation method thereof |
| CN101658168A (en) * | 2009-09-11 | 2010-03-03 | 中国农业大学 | Effervescent tablet of plant growth regulator composition and preparation method thereof |
| CN101791319A (en) * | 2010-04-07 | 2010-08-04 | 北京欧凯纳斯科技有限公司 | Female pudendum nursing product |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104138390A (en) * | 2014-06-11 | 2014-11-12 | 龚佳郎 | Chlorine dioxide effervescent tablet for killing barbier bacteria and fungi and preparation method thereof |
| CN105668730A (en) * | 2016-03-22 | 2016-06-15 | 江苏祥豪实业有限公司 | Novel chlorine dioxide material for treating water and method for preparing novel chlorine dioxide material |
| CN115777723A (en) * | 2023-02-07 | 2023-03-14 | 山东华实药业有限公司 | Instant chlorine dioxide effervescent tablet and preparation method thereof |
| CN115777723B (en) * | 2023-02-07 | 2023-04-07 | 山东华实药业有限公司 | Instant chlorine dioxide effervescent tablet and preparation method thereof |
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| CN102246819B (en) | 2013-12-18 |
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