CN102246793A - Antimicrobial composition and use thereof - Google Patents
Antimicrobial composition and use thereof Download PDFInfo
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- CN102246793A CN102246793A CN2011101513260A CN201110151326A CN102246793A CN 102246793 A CN102246793 A CN 102246793A CN 2011101513260 A CN2011101513260 A CN 2011101513260A CN 201110151326 A CN201110151326 A CN 201110151326A CN 102246793 A CN102246793 A CN 102246793A
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Abstract
The invention aims to provide an antimicrobial composition which is simple in formula and low in cost. When the antimicrobial composition is used, the antimicrobial effect can be ensured by a small dose of antimicrobial ingredient. Another aim of the invention is to provide the new use of a chemical composition in the preparation of antimicrobial products. The invention discloses the use of the chemical composition consisting of ethanol, polyhexamethylene biguanidine (PHMB) or salt of the polyhexamethylene biguanidine and isopropanol in preparation of antimicrobial composition products. The total weight of the ethanol and the isopropanol is not less than 48 to 80 percent.
Description
Technical field
The present invention relates to a kind of Chemical composition that and the application of said composition in preparation killing microorganisms product of killing microorganisms.
Background technology
Because increasing the weight of of global warming and environmental pollution, the variation of pathogenic microorganisms is accelerated; The abuse of various antibiotic, antiviral drugs; virus to antibiotic and the immunity of enantiopathy cytotoxic drug; and the generation of the pathogenic microorganisms of highly pathogenic highly infective is also being accelerated; breaking out of the infectious disease that reply and control are caused by pathogenic microorganisms with popular; just must control source of infection, cut off route of transmission and protection susceptible person; wherein, cutting off the route of transmission is safe and reliable important means.
Methylguanidine in poly hexamethylene biguanide (PHMB) compound has very high activity, easily by bacterium, viral adsorbed, directly act on microorganism, the division copy function that has suppressed bacterium, virus, the respiration channel of microorganism has been stopped up in its formation at microorganism body surface polymer, and microorganism is choked to death.Simultaneously, its high molecular polymer structure is improved the effective active of guanidine radicals, and bacterium is difficult for producing drug resistance.
This compound draws the systematic toxicology conclusion of hexamethylene: 1. low acute toxicity at last in the systematic Study of research, reviviscence toxicity research and the metabolism of the research of European medicine industry by studies on acute toxicity, human body toxicological study, Study on Subchronic, chronic toxicity and the carcinogenic possibility of system, genotoxicity; 2. when at normal using dosage, have low skin and eye irritation; 3. low long-term toxicity; 4. there is not genotoxicity; 5. non-teratogenesis; 6. by the no reviviscence toxicity that studies have shown that between two generations; 7. at the mankind, belong to the non-carcinogenic potential drug.
The bactericidal mechanism of ethanol, isopropyl alcohol mainly is by removing the lipid in the mycoderm that degerms, make the sex change of bacterium bacterium protein solidify performance sterilization or bacteriostasis, being widely used in the sterilization field.
Above-mentioned composition is good fit, and the performance synergy can obtain better bactericidal effect in the shorter time.
At present, Chinese patent literature discloses many antimicrobial products, and wherein part has selected for use alcohols, polymerization guanidine class etc. to be bactericidal active ingredient.
Application number is 200910114010.7 patent application document, and disclosing a kind of is that main bactericidal active ingredient, polyoxyethylene nonylphenol ether are the skin degerming product of surfactant by polyhexamethylene hydrochloric acid biguanides and ethanol; Application number is the Chinese patent application file of 03139745.x, discloses a kind of sterile products of being made up of 95% ethanol, poly hexamethylene biguanide, flavouring agent, water surplus; Application number is 200680032102.5 Chinese patent application file, discloses a kind ofly by poly hexamethylene biguanide, less important antimicrobial, and optional organic acid, handles the antimicrobial compositions that auxiliary agent such as pure and mild surfactant are formed; Application number is 200910114009.4 Chinese patent application file, a kind of prescription of liquid disinfectant is disclosed, with polyamine propyl group biguanides (claiming poly hexamethylene biguanide again) is main active ingredient, and selecting polyoxyethylene nonylphenol ether for use is surfactant, adds essence and makes.
More than invention all is difficult ethanol, poly hexamethylene biguanide or its salt, the isopropyl alcohol three composition antimicrobial products as bactericidal active ingredient.
Application number is 200980108019.5 Chinese patent application file, disclose a kind of pure antimicrobial skin health composition that comprises the cationic-compatible thickener, it comprises alcohol at least about 60%, thickened systems (be substantially free of cellulosic polymer, based on polymer or its composition of acrylate), is used for the cationic compound (as poly hexamethylene biguanide) of skin condition benefit etc.The present invention and its difference are, can not use thickened systems, satisfy the more products demand, perhaps use different thickened systems, common thickeners such as an amount of interpolation such as Hydroxypropyl methylcellulose, purpose is to prolong drying time, makes product in the article surface film forming, provide stronger fungicidal effectiveness, the longer antibacterial time.
Summary of the invention
The object of the present invention is to provide a kind of prescription simple, the killing microorganisms composition that cost is low; Have has a broad antifungal spectrum, the fast advantage of speed of action; Another object of the present invention is to provide the new application of a kind of Chemical composition that in preparation killing microorganisms product.
The present invention relates to contain the application of feedstock composition in preparation killing microorganisms product of poly hexamethylene biguanide (PHMB) or its salt, isopropyl alcohol.
Composition of the present invention can also add ethanol; Or the adding thickener, thickener only limits to cellulosic polymer or based on polymer or its composition of acrylate.
The percentage by weight sum of ethanol of the present invention and isopropyl alcohol is more than 48%, and is preferred 48% ~ 80%, and more preferably 48% ~ 70%, most preferably 48% ~ 60%.
The percentage by weight of poly hexamethylene biguanide of the present invention or its salt is for being no more than 12.5%, and is preferred 0.005% ~ 10%,
More preferably 0.01% ~ 2%.
This Chemical composition that can be independent or add acceptable auxiliary, base material, make required antimicrobial products.
Thickener can add 0.01% ~ 1% HPMC as thickener, prolong composition drying time, make product in the article surface film forming, provide stronger fungicidal effectiveness, the longer antibacterial time.
Advantage of the present invention is:
1, raw material is simple, and cost is low;
2, bactericidal effect is good, has a broad antifungal spectrum, and speed of action is fast, is particularly suited for the quick sterilization of hand, skin, and effect 1min can reach the sterilization requirement;
3, ethanol, isopropyl alcohol are volatile component in the composition, can be used for disposable prescription.
The product made from said composition, the sterilization of hand, skin, mucous membrane be can be used for extensive, safe, practically, sterilization, air sterillization, the pet sterilization of the general article surface of eating kitchenware etc. comprised in the occasions such as family, restaurant, hotel, public transport, kindergarten, hospital.
Essence for a better understanding of the present invention will illustrate its new application in the preparation antimicrobial products below with the anti-microbial test result of ethanol, hexamethylene, isopropyl alcohol example combinations.It is generally acknowledged that total alcohol amount is high more, anti-microbial effect is strong more.
One, the microorganism killing of composition of the present invention test
1, materials and methods
1.1 the active ingredient and the content of specimen (liquid preparation): hexamethylene content 0.3%, ethanol content 44%, isopropyl alcohol 4%.
1.2 test strain:
Escherichia coli (8099)
Staphylococcus aureus (ATCC 6538)
Pseudomonas aeruginosa (ATCC 15442)
Candida albicans (ATCC 10231)
Influenza virus (H
3N
2)
1.3 test basis:
Respective specified in Ministry of Public Health's " disinfection technology standard ".
2, result of the test
2.1 kill test to colibacillary
In test temperature is under 20 ℃ ± 1 ℃ condition, proves through 3 repeated tests, and specimen stoste effect 1.0min on average kills logarithm value to Escherichia coli〉5.00.(the results are shown in Table 1)
Table 1 pair colibacillary killing effect
2.2 the test of killing to staphylococcus aureus
In test temperature is under 20 ℃ ± 1 ℃ condition, proves through 3 repeated tests, and specimen stoste effect 1.0min on average kills logarithm value to staphylococcus aureus〉5.00.(the results are shown in Table 2)
The killing effect of table 2 pair staphylococcus aureus
2.3 the test of killing to pseudomonas aeruginosa
In test temperature is under 20 ℃ ± 1 ℃ condition, proves through 3 repeated tests, and specimen stoste effect 1.0min on average kills logarithm value to pseudomonas aeruginosa〉5.00.(the results are shown in Table 3)
The killing effect of table 3 pair pseudomonas aeruginosa
2.4 kill test to white is oidiomycetic
In test temperature is under 20 ℃ ± 1 ℃ condition, proves through 3 repeated tests, and specimen stoste effect 1.0min on average kills logarithm value to Candida albicans〉4.00.(the results are shown in Table 4)
The oidiomycetic killing effect of table 4 pair white
2.5 inactivation test to influenza virus
In test temperature is under 20 ℃ ± 1 ℃ condition, proves through 3 repeated tests, and specimen stoste effect 1.0min on average kills logarithm value to influenza virus〉4.00.(the results are shown in Table 5)
The inactivating efficacy of table 5 pair influenza virus
Annotate: average logarithm value of positive control and scope 4.32(4.23-4.50).
Two, the sterilization field trial of composition of the present invention
1, materials and methods
1.1 the active ingredient and the content of specimen (liquid preparation): hexamethylene content 0.3%, ethanol content 44%, isopropyl alcohol 4%.
1.2 test strain: natural bacteria.
1.3 dilution: the phosphate buffer of 0.1% Tween-80 (PBS), pH value 7.2 ~ 7.4.
1.4 neutralizer: the phosphate buffer (PBS) of 5.0% Tween-80 and 5g/L lecithin.
1.5 test basis:
Respective specified in Ministry of Public Health's " disinfection technology standard ".
1.6 test method
1.6.1 hand sterilization field trial
Behind the mutual rubbing of experimenter's both hands, the five fingers close up, and bedew in the test tube that contains the 10ml dilution with aseptic cotton swab, and its left hand the five fingers face of counting on one's fingers is wiped 2 times to referring to that root comes and goes from finger tip, in the sterile working mode sampling end is cut into former dilution in vitro, as positive controls.After the sampling, get specimen stoste, behind skin wiping sterilization 1min, in the test tube that contains 10ml neutralizer solution, bedew, its right hand is sampled with same procedure, as the sterilization group with aseptic cotton swab.Control group and sterilization group sample liquid are fully beaten with suitable dilution factor absorption 1.0ml inoculation plate, in duplicate, pour into tryptose soya agar medium (TSA) behind each winding kind plate, after the condensation together with nonvaccinated test culture medium flat plate, put and cultivate 48h in 37 ℃ of incubators, counting survival clump count calculates and kills logarithm value.
1.6.2 skin degerming field trial
Before the sterilization, behind the mutually abundant rubbing in the inboard stage casing of experimenter left and right sides forearm, dimension board is put in section surface in experimenter's left forearm inboard, bedew in the test tube that contains the 10ml dilution with aseptic cotton swab, after drying on the tube wall, in the zone that dimension board is confined, lateral shuttle is embrocated 10 times, vertically double rub is 3 times, whenever embrocates one time, and cotton swab is rotated one time.In the sterile working mode sampling end is cut into former dilution in vitro, as positive controls.After the sampling, get specimen stoste, behind skin wiping sterilization 1min, in containing 10ml neutralizer solution test tube, bedew, its right forearm is sampled with same procedure, as experimental group with aseptic cotton swab.Control group and sterilization group sample liquid are fully beaten with suitable dilution factor absorption 1.0ml inoculation plate, in duplicate, pour into tryptose soya agar medium (TSA) behind each winding kind plate, after the condensation together with nonvaccinated test culture medium flat plate, put and cultivate 48h in 37 ℃ of incubators, counting survival clump count calculates and kills logarithm value.
2, result of the test
2.1 hand sterilization field trial
Through 30 person-times of repeated tests, specimen stoste effect 1min on average kills logarithm value to the natural bacteria on hand surface〉1.00(sees Table 6).
Table 6 hand sterilization site test results
2.2 skin degerming field trial
Through 30 person-times of repeated tests, specimen stoste effect 1min on average kills logarithm value to the natural bacteria of skin surface〉1.00(sees Table 7).
Table 7 skin degerming site test results
Embodiment
Further specify technical solution of the present invention below in conjunction with specific embodiment, these embodiment can not be interpreted as it is restriction to technical solution.
Embodiment 1
Prepare thimerosal according to following steps: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 1kg and be stirred to transparent clarification.In preparing tank, add the 200L purified water, stir and add bronopol 0.3kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol (volume ratio down successively, being converted into mass ratio is 92.3%, 445kg, isopropyl alcohol 39kg, glycerine 10kg, Hydroxypropyl methylcellulose solution down together), finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, qualified back packing.
Wherein, glycerine has the effect of skin moisten skin care, can slow down the stimulation of alcohols solvent to skin, simultaneously, can prolong drying time, strengthens antibacterial effect; HPMC can make this thimerosal in skin and article surface film forming, prolongs the antibacterial time; Bronopol is used used as stabilizers in this product.
Stability meets the requirement of Ministry of Health of the People's Republic of China's " disinfection technology standard " (version in 2002), the term of validity 24 months.
Through check, to chmice acute per os LD
50＞5000 mg/kg body weight, true border is nontoxic; Repeatedly intact skin irritant test total mark mean value is 0, skin irritation index＜0.5, and stimulus intensity belongs to nonirritant; PCEMNR there is not the micronucleus of causing effect; It is 1000 mg/kg body weight that maximum is not observed illeffects dosage.
In the said composition, ethanol content by weight 45.6%, isopropyl alcohol 4.3%, hexamethylene 0.33%.
Embodiment 2
The preparation method of this sanitizing composition is adsorbed in the thimerosal for preparing in the nonwoven as the wet tissue annex solution with example 1, makes wet sanitary napkins.
After testing, under 20 ℃ ± 1 ℃ condition, wet sanitary napkins effect 1 min, colibacillary average kill ratio is 100%, the average kill ratio of staphylococcus aureus is 100%, the average kill ratio of pseudomonas aeruginosa is 100%, average kill ratio to hemolytic streptococcus is 99.94%, to the oidiomycetic average kill ratio of white is 99.91%, to influenza virus on average kill logarithm value＞3.00, to deactivation logarithm value＞3.00 of HIV virus.
Hand sterilization field trial: through 30 person-times of repeated tests, wet sanitary napkins effect 1min on average kills logarithm value＞1.00 to the natural bacteria on hand surface.
Escherichia coli simulated field sterilizing test: prove through 30 sampling tests, pollute colibacillary body surface 1min with the wet sanitary napkins wiping, the Escherichia coli average kill ratio that body surface is polluted is 100%.
Keep in relative moisture under 〉=75% the condition, place 14 days (being equivalent to room temperature placed 1 year) in 54 ℃ of insulating boxs after, wet sanitary napkins effect 1min still is 100% to colibacillary average kill ratio.
Embodiment 3
Prepare thimerosal according to following steps: in stainless steel cask, add the hot purified water of 20L, be weighed into Hydroxypropyl methylcellulose 0.5kg and be stirred to transparent clarification.In preparing tank, add 95% ethanol 824kg, stir and add bronopol 0.3kg, 20% hexamethylene aqueous solution 5kg, isopropyl alcohol 39kg, glycerine 1kg, Hydroxypropyl methylcellulose solution down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to 1000kg, continue to stir 15 minutes.Check, qualified back packing.
The thimerosal for preparing also can be used as the wet tissue annex solution and is adsorbed in the nonwoven, makes wet sanitary napkins.
Embodiment 4
Prepare thimerosal according to following steps: in stainless steel cask, add the hot purified water of 20L, be weighed into Hydroxypropyl methylcellulose 1kg and be stirred to transparent clarification.In preparing tank, add 95% ethanol 770kg, stir and add bronopol 0.3kg, 20% hexamethylene aqueous solution 5kg, isopropyl alcohol 39kg, glycerine 10kg, Hydroxypropyl methylcellulose solution down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to 1000kg, continue to stir 15 minutes.Check, qualified back packing.
The thimerosal for preparing also can be used as the wet tissue annex solution and is adsorbed in the nonwoven, makes wet sanitary napkins.
Embodiment 5
Prepare spray according to following steps: in preparing tank, add the 10L purified water, stir and add bronopol 0.3kg, 20% hexamethylene aqueous solution 0.25kg, 95% ethanol 658kg, isopropyl alcohol 39kg down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to 1000kg, continue to stir 15 minutes.Check, be sub-packed in after qualified in the spray bottle of band hand pump.
Embodiment 6
Prepare wet mop towel according to following steps: in preparing tank, add the 10L purified water, stir and add bronopol 0.2kg, 20% hexamethylene aqueous solution 0.5kg, 95% ethanol 690kg, isopropyl alcohol 80kg down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to 1000kg, continue to stir 15 minutes.Check, qualified back are adsorbed in the nonwoven as the wet mop towel annex solution, make wet mop towel.
Embodiment 7
Prepare wet mop towel according to following steps: in preparing tank, add 20% hexamethylene aqueous solution 100kg, stir and add bronopol 0.4kg, 95% ethanol 658kg, isopropyl alcohol 39kg down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to 1000kg, continue to stir 15 minutes.Check, qualified back are adsorbed in the nonwoven as the wet mop towel annex solution, make wet mop towel.
Embodiment 8
Prepare wet mop towel according to following steps: in preparing tank, add 20% hexamethylene aqueous solution 500kg, stir and add bronopol 0.6kg, 95% ethanol 10kg, isopropyl alcohol 480kg down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to 1000kg, continue to stir 15 minutes.Check, qualified back are adsorbed in the nonwoven as the wet mop towel annex solution, make wet mop towel.
Embodiment 9
Prepare thimerosal according to following steps: in stainless steel cask, add the hot purified water of 10L, be weighed into Hydroxypropyl methylcellulose 0.2kg and be stirred to transparent clarification.In preparing tank, add the 20L purified water, stir and add bronopol 0.5kg, 20% hexamethylene aqueous solution 16.5kg, 95% ethanol 465kg, isopropyl alcohol 195kg, ethylhexyl glycerine (a kind of 1-alkyl glycerol ether compound) 10kg, Hydroxypropyl methylcellulose solution down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, qualified back packing.
The thimerosal for preparing also can be used as the wet tissue annex solution and is adsorbed in the nonwoven, makes wet sanitary napkins.
Embodiment 10
Prepare thimerosal according to following steps: in stainless steel cask, add the hot purified water of 10L, be weighed into Hydroxypropyl methylcellulose 0.7kg and be stirred to transparent clarification.In preparing tank, add the 20L purified water, stir and add bronopol 0.8kg, the 20% hexamethylene aqueous solution, 22.5 kg, 95% ethanol 560kg, isopropyl alcohol 154kg, glycerine 8kg, Hydroxypropyl methylcellulose solution down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to 1000kg, continue to stir 15 minutes.Check, qualified back packing.
The thimerosal for preparing also can be used as the wet tissue annex solution and is adsorbed in the nonwoven, makes wet sanitary napkins.
Embodiment 11
Prepare thimerosal according to following steps: in stainless steel cask, add the hot purified water of 20L, be weighed into Hydroxypropyl methylcellulose 1kg and be stirred to transparent clarification.In preparing tank, add the 20L purified water, stir and add bronopol 0.9kg, the 20% hexamethylene aqueous solution, 15.5 kg, 95% ethanol, 550 kg, isopropyl alcohol 40 kg, ethylhexyl glycerine (a kind of 1-alkyl glycerol ether compound) 10kg, ethohexadiol 3kg, Hydroxypropyl methylcellulose solution down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to 1000kg, continue to stir 15 minutes.Check, qualified back packing.
The thimerosal for preparing also can be used as the wet tissue annex solution and is adsorbed in the nonwoven, makes wet sanitary napkins.
Embodiment 12
Prepare thimerosal according to following steps: in preparing tank, add the 20L purified water, stir and add bronopol 1.0kg, 20% hexamethylene aqueous solution 3kg, 95% ethanol 563kg, isopropyl alcohol 180kg, glycerine 6kg down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to 1000kg, continue to stir 15 minutes.Check, qualified back packing.
The thimerosal for preparing also can be used as the wet tissue annex solution and is adsorbed in the nonwoven, makes wet sanitary napkins.
Embodiment 13
Prepare thimerosal according to following steps: in preparing tank, add the 20L purified water, stir and add bronopol 0.3kg, 20% hexamethylene aqueous solution 20kg, 95% ethanol 534kg, isopropyl alcohol 51 kg, glycerine 5kg down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to 1000kg, continue to stir 15 minutes.Check, qualified back packing.
The thimerosal for preparing also can be used as the wet tissue annex solution and is adsorbed in the nonwoven, makes wet sanitary napkins.
Embodiment 14
Prepare thimerosal according to following steps: in preparing tank, add the 20L purified water, stir and add 20% hexamethylene aqueous solution 10kg, 95% ethanol 563kg, isopropyl alcohol 33kg down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to 1000kg, continue to stir 15 minutes.Check, qualified back packing.
The thimerosal for preparing also can be used as the wet tissue annex solution and is adsorbed in the nonwoven, makes wet sanitary napkins.
Embodiment 15
Prepare aerosol according to following steps: in preparing tank, add the 20L purified water, stir and add bronopol 0.5kg, the 20% hexamethylene aqueous solution, 0.5 kg, 95% ethanol, 506 kg, isopropyl alcohol 154 kg down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to 1000kg, continue to stir 15 minutes, it is sealed in the pressure vessel, refills a certain amount of propellant.
Embodiment 16
Prepare the sterilization spray according to following steps: in preparing tank, add the 20L purified water, stir and add bronopol 0.6kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol, 558 kg, isopropyl alcohol 54 kg, PPG-20 methyl glucose ether (a kind of glucosan derivative) 50 kg down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to 1000kg, continue to stir 15 minutes.Check, be sub-packed in after qualified in the spray bottle of band hand pump.
Embodiment 17
Prepare the sterilization spray according to following steps: in preparing tank, add the 20L purified water, stir and add bronopol 0.6kg, 20% hexamethylene aqueous solution 2kg, 95% ethanol 578kg, isopropyl alcohol 40kg, extract solution from aloe 1 kg, glycerine 2 kg down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to 1000kg, continue to stir 15 minutes.Check, be sub-packed in after qualified in the spray bottle of band hand pump.
Embodiment 18
Prepare wet wiping towel according to following steps: in preparing tank, add the 20L purified water, stir and add bronopol 0.7kg, 20% hexamethylene aqueous solution 4kg, 95% ethanol 490kg, isopropyl alcohol 150kg, jojoba oil 2 kg, marine algae extract 1 kg down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to 1000kg, continue to stir 15 minutes.The liquid for preparing is adsorbed in the nonwoven as the wet wiping towel annex solution, makes wet wiping towel.
Embodiment 19
Prepare wet wiping towel according to following steps: in preparing tank, add the 20L purified water, stir and add bronopol 0.3kg, 20% hexamethylene aqueous solution 5kg, 95% ethanol 525kg, isopropyl alcohol 15kg, hyaluronic acid 5 kg down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to 1000kg, continue to stir 15 minutes.The liquid for preparing is adsorbed in the nonwoven as the wet wiping towel annex solution, makes wet wiping towel.
Embodiment 20
Prepare the sterilization spray according to following steps: in preparing tank, add the 20L purified water, stir and add bronopol 0.5kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol 540kg, isopropyl alcohol 39kg, shitosan 10 kg down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to 1000kg, continue to stir 15 minutes.Check, be sub-packed in after qualified in the spray bottle of band hand pump.
Embodiment 21
Prepare thimerosal according to following steps: in preparing tank, add the 20L purified water, stir and add bronopol 0.1kg, 20% hexamethylene aqueous solution 35kg, 95% ethanol 684kg, isopropyl alcohol 12kg, ceramide 1 kg, glycerine 2kg down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to 1000kg, continue to stir 15 minutes.Check, qualified back packing.
The thimerosal for preparing also can be used as the wet tissue annex solution and is adsorbed in the nonwoven, makes wet sanitary napkins.
Embodiment 22
Prepare gel according to following steps: in stainless steel cask, add the hot purified water of 40L, be weighed into hydroxyethylcellulose 150kg and be stirred to transparent clarification.In preparing tank, add the 100L purified water, stir and add bronopol 0.3kg, 20% hexamethylene aqueous solution 12kg, 95% ethanol 490kg, isopropyl alcohol 28kg, glycerine 9kg, hydroxy ethyl fiber cellulose solution down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to 1000kg, continue to stir 15 minutes.Check, qualified back packing.
Embodiment 23
Prepare thimerosal according to following steps: in preparing tank, add the 20L purified water, stir and add bronopol 0.6kg, 20% hexamethylene aqueous solution 13kg, 95% ethanol 200kg, isopropyl alcohol 330kg, glycerine 7kg down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to 1000kg, continue to stir 15 minutes.Check, qualified back packing.
The thimerosal for preparing also can be used as the wet tissue annex solution and is adsorbed in the nonwoven, makes wet sanitary napkins.
Embodiment 24
Prepare wet mop towel according to following steps: in preparing tank, add 20% hexamethylene aqueous solution 100kg, stir and add bronopol 0.4kg, isopropyl alcohol 658kg down successively, finish stirring and stop after 5 ~ 10 minutes stirring, add purified water, continue to stir 15 minutes to 1000kg.Check, qualified back are adsorbed in the nonwoven as the wet mop towel annex solution, make wet mop towel.
Claims (10)
1. the feedstock composition that contains poly hexamethylene biguanide (PHMB) or its salt, isopropyl alcohol is in the preparation killing microorganisms product
Use.
2. the described composition of claim 1 is characterized in that: can also add ethanol.
3. claim 1 or 2 arbitrary described compositions, it is characterized in that: can also add thickener, thickener only limits to fibre
Tie up plain polymer or based on polymer or its composition of acrylate.
4. the described composition of claim 2, it is characterized in that: the percentage by weight sum of ethanol and isopropyl alcohol is more than 48%.
5. the described composition of claim 4, it is characterized in that: the percentage by weight sum of ethanol and isopropyl alcohol is 48% ~ 80%.
6. the described composition of claim 5, it is characterized in that: the percentage by weight sum of ethanol and isopropyl alcohol is 48% ~ 70%.
7. the described composition of claim 6, it is characterized in that: the percentage by weight sum of ethanol and isopropyl alcohol is 48% ~ 60%.
8. the arbitrary described composition of claim 1-2 is characterized in that: the percentage by weight of poly hexamethylene biguanide or its salt is not for
Surpass 12.5%.
9. the described composition of claim 8, it is characterized in that: the percentage by weight of poly hexamethylene biguanide or its salt is 0.005%
~10%。
10. the described composition of claim 9, it is characterized in that: the percentage by weight of poly hexamethylene biguanide or its salt is 0.01%
~2%。
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| CN105284860A (en) * | 2014-06-16 | 2016-02-03 | 盐城市聚科化工有限公司 | Multiple-effect antibacterial agent composition for wet tissue and production method thereof |
| CN105535014A (en) * | 2015-11-30 | 2016-05-04 | 湖北微控生物科技有限公司 | Skin and hand disinfectant |
| CN108042562A (en) * | 2017-12-22 | 2018-05-18 | 北京长江脉医药科技有限责任公司 | Disposable disinfectant of the compound alcohol of gel-type and preparation method thereof |
| CN111773241A (en) * | 2020-07-21 | 2020-10-16 | 贵州威克斯医疗科技有限公司 | Composition containing PHMB for preventing and relieving diaper eczema |
| CN111851071A (en) * | 2020-07-27 | 2020-10-30 | 广东德美精细化工集团股份有限公司 | Antiviral finishing agent and preparation method and application thereof |
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| CN105284860A (en) * | 2014-06-16 | 2016-02-03 | 盐城市聚科化工有限公司 | Multiple-effect antibacterial agent composition for wet tissue and production method thereof |
| CN105535014A (en) * | 2015-11-30 | 2016-05-04 | 湖北微控生物科技有限公司 | Skin and hand disinfectant |
| CN108042562A (en) * | 2017-12-22 | 2018-05-18 | 北京长江脉医药科技有限责任公司 | Disposable disinfectant of the compound alcohol of gel-type and preparation method thereof |
| CN113712908A (en) * | 2020-05-25 | 2021-11-30 | 南京帝昌医药科技有限公司 | Composition for treating allergic conjunctivitis and preparation method thereof |
| CN111773241A (en) * | 2020-07-21 | 2020-10-16 | 贵州威克斯医疗科技有限公司 | Composition containing PHMB for preventing and relieving diaper eczema |
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