CN102240378A - Pharmaceutical composition for treating gout and preparation method thereof - Google Patents
Pharmaceutical composition for treating gout and preparation method thereof Download PDFInfo
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- CN102240378A CN102240378A CN2010101730605A CN201010173060A CN102240378A CN 102240378 A CN102240378 A CN 102240378A CN 2010101730605 A CN2010101730605 A CN 2010101730605A CN 201010173060 A CN201010173060 A CN 201010173060A CN 102240378 A CN102240378 A CN 102240378A
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Abstract
The invention relates to a pharmaceutical composition for treating gout and a preparation method thereof, belonging to the technical field of traditional Chinese medicine. The composition is prepared from medicinal materials such as fineleaf schizonepeta herb, cassia twig and the like, and has good effect.
Description
Technical field
The present invention is a kind of pharmaceutical composition and method for making for the treatment of gout, belongs to the technical field of medicine.
Technical background
At present, along with people's raising of quality of life, the improvement of dietary structure, gout presents rapid growth trend as obesity, diabetes, hypertension.Gout is more common in fat middle-aged male, single joint around main the infringement.Outbreak first mostly is first metatarsophalangeal joints, is migration, and onset is unexpected, and redness and swelling of joints, burning pain, limitation of activity peaked in one day, and day light night is heavy.Outbreak causes joint plumpness, deformity, stiff repeatedly.Be everlasting in auricle, the juxtra-articular skeleton, in the stndon sheath cartilage, locate to form tophus in subcutaneous tissue, the kidney etc., claim also " tophus " that late period, renal function obviously went down, and uremia occurred, threat to life.Shortcomings such as though the medicine of western medical treatment gout a lot, and existence is easily recurred, side effect is many.
In view of such circumstances, providing a kind of determined curative effect, toxic and side effects pharmaceutical composition little, taking convenience is the thing of being badly in need of solution.
Summary of the invention
Technical problem to be solved by this invention provides a kind of pharmaceutical composition and method for making for the treatment of gout; The present invention is directed to prior art, little, the taking convenience of product determined curative effect, toxic and side effects that provides.
Technical scheme of the present invention is to constitute like this: it is made up of following active drug raw material: Herba Schizonepetae 5-50g, Ramulus Cinnamomi 5-50g, Caulis Piperis Kadsurae 5-50g, Radix Toddaliae Asiaticae 5-50g, Herba Lycopodii 5-50g, dodder laurel 5-50g, Herba Lysimachiae 5-50g, Poria 5-50g, Rhizoma Curcumae 5-50g, Caulis Spatholobi 5-50g, Cortex Magnoliae Officinalis 5-50g, Cortex Phellodendri 3-50g, Radix Glycyrrhizae 3-50g.Be preferably: Herba Schizonepetae 10-30g, Ramulus Cinnamomi 10-30g, Caulis Piperis Kadsurae 10-30g, Radix Toddaliae Asiaticae 10-30g, Herba Lycopodii 10-30g, dodder laurel 10-30g, Herba Lysimachiae 10-30g, Poria 10-30g, Rhizoma Curcumae 10-30g, Caulis Spatholobi 10-30g, Cortex Magnoliae Officinalis 10-30g, Cortex Phellodendri 5-25g, Radix Glycyrrhizae 5-20g.The method for making of described pharmaceutical composition: the raw material of getting it filled, pulverize or extract, make multiple peroral dosage form then respectively, comprising: tablet, dispersible tablet, capsule, soft capsule, granule, pill, powder, drop pill, gel, oral liquid.
Herba Schizonepetae, Ramulus Cinnamomi relieving the exterior syndrome with drugs of pungent in flavor and warm in nature; Caulis Piperis Kadsurae, Radix Toddaliae Asiaticae, Herba Lycopodii wind-damp dispelling; The dodder laurel clearing away heat-damp and promoting diuresis, cooling blood for hemostasis; Herba Lysimachiae, Poria promoting diuresis to eliminate damp pathogen; Rhizoma Curcumae, Caulis Spatholobi blood circulation promoting and blood stasis dispelling; The Cortex Magnoliae Officinalis removing dampness by means of aromatics; The Cortex Phellodendri heat clearing and damp drying; The Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.
Pharmacodynamic experiment utilization uric acid sodium causes the ankle swelling in rat method, and hypoxanthine causes mice gout method and observes its gout effect; Mice caused by dimethylbenzene xylene auricle edema method, angle justice dish glue causes the rat paw edema method and the carboxymethyl cellulose pouch method is observed its antiinflammatory action.The result shows that this product has tangible reduction gout mice serum uric acid level and antiinflammatory action.And have and increase the trend that gout mouse retention uric acid is discharged.
Concrete embodiment
Embodiment 1: Herba Schizonepetae 20g, Ramulus Cinnamomi 20g, Caulis Piperis Kadsurae 20g, Radix Toddaliae Asiaticae 20g, Herba Lycopodii 20g, dodder laurel 20g, Herba Lysimachiae 20g, Poria 20g, Rhizoma Curcumae 20g, Caulis Spatholobi 20g, Cortex Magnoliae Officinalis 20g, Cortex Phellodendri 15g, Radix Glycyrrhizae 10g
Above flavour of a drug decoct with water 3 times, and each 2 hours, each amount of water was 8 times of medical material, collecting decoction, filter, filtrate concentrates, and adding ethanol is 50% to containing the alcohol amount, leaves standstill 24 hours, filter, filtrate recycling ethanol concentrates drying to there not being the alcohol flavor, get dry extract, add starch, grinding and sieving, granulate with dehydrated alcohol, granulate promptly gets granule, oral, a 5g, 3 times on the one.
Embodiment 2: Herba Schizonepetae 10g, Ramulus Cinnamomi 10g, Caulis Piperis Kadsurae 10g, Radix Toddaliae Asiaticae 10g, Herba Lycopodii 10g, dodder laurel 10g, Herba Lysimachiae 10g, Poria 10g, Rhizoma Curcumae 10g, Caulis Spatholobi 10g, Cortex Magnoliae Officinalis 10g, Cortex Phellodendri 5g, Radix Glycyrrhizae 5g
Above flavour of a drug decoct with water 4 times, and each 3 hours, each amount of water was 8 times of medical material, collecting decoction filters, and filtrate concentrates, adding ethanol is 50% to containing the alcohol amount, leaves standstill 36 hours, filters, filtrate recycling ethanol concentrates drying under reduced pressure to there not being the alcohol flavor, get dry extract, add starch, grinding and sieving, tabletting promptly gets tablet.
Embodiment 3: Herba Schizonepetae 30g, Ramulus Cinnamomi 30g, Caulis Piperis Kadsurae 30g, Radix Toddaliae Asiaticae 30g, Herba Lycopodii 30g, dodder laurel 30g, Herba Lysimachiae 30g, Poria 30g, Rhizoma Curcumae 30g, Caulis Spatholobi 30g, Cortex Magnoliae Officinalis 30g, Cortex Phellodendri 25g, Radix Glycyrrhizae 20g
Above flavour of a drug decoct with water 2 times, and each 4 hours, each amount of water was 8 times of medical material, collecting decoction, filter, filtrate concentrates, and adding ethanol is 50% to containing the alcohol amount, leaves standstill 12 hours, filters, filtrate recycling ethanol concentrates to there not being the alcohol flavor, and drying under reduced pressure is moulded the method for making pill, promptly gets soft capsule.
Embodiment 4: Herba Schizonepetae 5g, Ramulus Cinnamomi 5g, Caulis Piperis Kadsurae 5g, Radix Toddaliae Asiaticae 5g, Herba Lycopodii 5g, dodder laurel 5g, Herba Lysimachiae 5g, Poria 5g, Rhizoma Curcumae 5g, Caulis Spatholobi 5g, Cortex Magnoliae Officinalis 5g, Cortex Phellodendri 3g, Radix Glycyrrhizae 3g
Above flavour of a drug decoct with water three times, add 4 times of water gagings at every turn and decoct 2 hours, and collecting decoction filters, and concentrates, and promptly gets oral liquid.
Embodiment 5: Herba Schizonepetae 50g, Ramulus Cinnamomi 50g, Caulis Piperis Kadsurae 50g, Radix Toddaliae Asiaticae 50g, Herba Lycopodii 50g, dodder laurel 50g, Herba Lysimachiae 50g, Poria 50g, Rhizoma Curcumae 50g, Caulis Spatholobi 50g, Cortex Magnoliae Officinalis 50g, Cortex Phellodendri 50g, Radix Glycyrrhizae 50g
Above flavour of a drug decoct with water three times, add 4 times of water gagings at every turn and decoct 1.5 hours, and collecting decoction filters, and concentrates, and promptly gets oral liquid.
Embodiment 6: Herba Schizonepetae 10g, Ramulus Cinnamomi 6g, Caulis Piperis Kadsurae 8g, Radix Toddaliae Asiaticae 20g, Herba Lycopodii 10g, dodder laurel 30g, Herba Lysimachiae 40g, Poria 20g, Rhizoma Curcumae 15g, Caulis Spatholobi 10g, Cortex Magnoliae Officinalis 20g, Cortex Phellodendri 4g, Radix Glycyrrhizae 5g
Above flavour of a drug decoct with water three times, add 6 times of water gagings at every turn and decoct 3 hours, and collecting decoction filters, and concentrates, and general method for making pill promptly gets pill.
Embodiment 7: Herba Schizonepetae 22g, Ramulus Cinnamomi 23g, Caulis Piperis Kadsurae 17g, Radix Toddaliae Asiaticae 18g, Herba Lycopodii 20g, dodder laurel 30g, Herba Lysimachiae 10g, Poria 40g, Rhizoma Curcumae 50g, Caulis Spatholobi 50g, Cortex Magnoliae Officinalis 10g, Cortex Phellodendri 3g, Radix Glycyrrhizae 4g
Above flavour of a drug decoct with water three times, add 7 times of water gagings at every turn and decoct 2.5 hours, and collecting decoction filters, and concentrates, and extrudes-the spheronization pill, promptly gets pellet.
Embodiment 8: Herba Schizonepetae 11g, Ramulus Cinnamomi 28g, Caulis Piperis Kadsurae 29g, Radix Toddaliae Asiaticae 13g, Herba Lycopodii 12g, dodder laurel 20g, Herba Lysimachiae 20g, Poria 22g, Rhizoma Curcumae 25g, Caulis Spatholobi 10g, Cortex Magnoliae Officinalis 20g, Cortex Phellodendri 8g, Radix Glycyrrhizae 9g
Above flavour of a drug decoct with water three times, add 5 times of water gagings at every turn and decoct 2.5 hours, and collecting decoction filters, and concentrate, and drying is pulverized, and promptly gets powder.
Embodiment 9: Herba Schizonepetae 17g, Ramulus Cinnamomi 18g, Caulis Piperis Kadsurae 20g, Radix Toddaliae Asiaticae 20g, Herba Lycopodii 27g, dodder laurel 18g, Herba Lysimachiae 20g, Poria 21g, Rhizoma Curcumae 24g, Caulis Spatholobi 16g, Cortex Magnoliae Officinalis 12g, Cortex Phellodendri 7g, Radix Glycyrrhizae 5g
Above flavour of a drug decoct with water three times, add 3 times of water gagings at every turn and decoct 3 hours, and collecting decoction filters, and concentrate, and drying is pulverized, and promptly gets powder.
Claims (3)
1. pharmaceutical composition for the treatment of gout, it is characterized in that: it is made up of following active drug raw material: Herba Schizonepetae 5-50g, Ramulus Cinnamomi 5-50g, Caulis Piperis Kadsurae 5-50g, Radix Toddaliae Asiaticae 5-50g, Herba Lycopodii 5-50g, dodder laurel 5-50g, Herba Lysimachiae 5-50g, Poria 5-50g, Rhizoma Curcumae 5-50g, Caulis Spatholobi 5-50g, Cortex Magnoliae Officinalis 5-50g, Cortex Phellodendri 3-50g, Radix Glycyrrhizae 3-50g.
2. according to the pharmaceutical composition of the described treatment gout of claim 1, it is characterized in that: it is made up of following active drug raw material: Herba Schizonepetae 10-30g, Ramulus Cinnamomi 10-30g, Caulis Piperis Kadsurae 10-30g, Radix Toddaliae Asiaticae 10-30g, Herba Lycopodii 10-30g, dodder laurel 10-30g, Herba Lysimachiae 10-30g, Poria 10-30g, Rhizoma Curcumae 10-30g, Caulis Spatholobi 10-30g, Cortex Magnoliae Officinalis 10-30g, Cortex Phellodendri 5-25g, Radix Glycyrrhizae 5-20g.
3. according to the method for making of the pharmaceutical composition of any described treatment gout of claim 1-2, it is characterized in that: the raw material of getting it filled, pulverize or extract, make multiple peroral dosage form then respectively, comprising: tablet, dispersible tablet, capsule, soft capsule, granule, pill, powder, drop pill, gel, oral liquid.
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| CN2010101730605A CN102240378A (en) | 2010-05-10 | 2010-05-10 | Pharmaceutical composition for treating gout and preparation method thereof |
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| CN2010101730605A CN102240378A (en) | 2010-05-10 | 2010-05-10 | Pharmaceutical composition for treating gout and preparation method thereof |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105288519A (en) * | 2015-12-14 | 2016-02-03 | 华坚 | Traditional Chinese medicine composition for treating gout and preparation method thereof |
| CN105288518A (en) * | 2015-12-14 | 2016-02-03 | 华坚 | Traditional Chinese medicine composition for treating gout and preparation method thereof |
| CN105311586A (en) * | 2015-12-14 | 2016-02-10 | 华坚 | Traditional Chinese medicine composition for treating gout and preparation method thereof |
| CN105343799A (en) * | 2015-12-14 | 2016-02-24 | 华坚 | Traditional Chinese medicinal composition for treating gout and preparation method of traditional Chinese medicinal composition |
| CN105343802A (en) * | 2015-12-14 | 2016-02-24 | 华坚 | Traditional Chinese medicinal composition for treating gout and preparation method of traditional Chinese medicinal composition |
| CN105343801A (en) * | 2015-12-14 | 2016-02-24 | 华坚 | Traditional Chinese medicinal composition for treating gout and preparation method of traditional Chinese medicinal composition |
| CN105362951A (en) * | 2015-12-14 | 2016-03-02 | 华坚 | Traditional Chinese medicinal composition for treating gout and preparation method of traditional Chinese medicinal composition |
| CN105435100A (en) * | 2015-12-14 | 2016-03-30 | 华坚 | Traditional Chinese medicine composition for treating gout and preparation method thereof |
| CN109820974A (en) * | 2019-03-27 | 2019-05-31 | 苏凤哲 | A kind of Chinese medicine composition and its preparation method and application for treating hyperuricemia |
-
2010
- 2010-05-10 CN CN2010101730605A patent/CN102240378A/en active Pending
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105288519A (en) * | 2015-12-14 | 2016-02-03 | 华坚 | Traditional Chinese medicine composition for treating gout and preparation method thereof |
| CN105288518A (en) * | 2015-12-14 | 2016-02-03 | 华坚 | Traditional Chinese medicine composition for treating gout and preparation method thereof |
| CN105311586A (en) * | 2015-12-14 | 2016-02-10 | 华坚 | Traditional Chinese medicine composition for treating gout and preparation method thereof |
| CN105343799A (en) * | 2015-12-14 | 2016-02-24 | 华坚 | Traditional Chinese medicinal composition for treating gout and preparation method of traditional Chinese medicinal composition |
| CN105343802A (en) * | 2015-12-14 | 2016-02-24 | 华坚 | Traditional Chinese medicinal composition for treating gout and preparation method of traditional Chinese medicinal composition |
| CN105343801A (en) * | 2015-12-14 | 2016-02-24 | 华坚 | Traditional Chinese medicinal composition for treating gout and preparation method of traditional Chinese medicinal composition |
| CN105362951A (en) * | 2015-12-14 | 2016-03-02 | 华坚 | Traditional Chinese medicinal composition for treating gout and preparation method of traditional Chinese medicinal composition |
| CN105435100A (en) * | 2015-12-14 | 2016-03-30 | 华坚 | Traditional Chinese medicine composition for treating gout and preparation method thereof |
| WO2017101151A1 (en) * | 2015-12-14 | 2017-06-22 | 华坚 | Gout treating traditional chinese medicine composition and preparation method therefor |
| CN109820974A (en) * | 2019-03-27 | 2019-05-31 | 苏凤哲 | A kind of Chinese medicine composition and its preparation method and application for treating hyperuricemia |
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Application publication date: 20111116 |