CN102217939B - Micro tip array electrode used for minimally invasive dynamic glucose monitoring - Google Patents
Micro tip array electrode used for minimally invasive dynamic glucose monitoring Download PDFInfo
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- CN102217939B CN102217939B CN 201110138226 CN201110138226A CN102217939B CN 102217939 B CN102217939 B CN 102217939B CN 201110138226 CN201110138226 CN 201110138226 CN 201110138226 A CN201110138226 A CN 201110138226A CN 102217939 B CN102217939 B CN 102217939B
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Abstract
The invention relates to a micro tip array electrode used for minimally invasive dynamic glucose monitoring in the technical field of medical monitoring instruments. The micro tip array electrode comprises a support structure and three electrode structures fixedly connected with the support structure, wherein the electrode structure is composed of an electrode micro tip array and an electrode conduction structure which are connected, and the three electrode conduction structures are all fixedly connected with the support structure. The micro tip array of each electrode in the invention penetrates into and stops at a shallow layer of skin of a human body, and a glucose reaction current in a body fluid can be continuously detected and converted into glucose concentration parameters to be output at regular time, thus minimally invasive continuous glucose monitoring is realized, and the micro tip array electrode has the characteristics of simpleness in operation and slight wound.
Description
Technical field
What the present invention relates to is a kind of device of medical monitoring Instrument technology field, specifically a kind of micro tips array electrode for Wicresoft's Dynamic Blood Glucose Monitoring.
Background technology
Blood glucose value is the very responsive index that directly reflects the interior islet function damage situations of diabetics body and therapeutic effect, so blood sugar monitoring is the key in the treating diabetes.Because the blood sugar for human body level is among the continuous variation, according to external the method for monitoring after the present blood sampling, realize the monitor closely blood sugar level always, must repeatedly take a blood sample every day, give patient's the human body and bring mentally heavy burden.Therefore, the most desirable blood sugar test mode is real-time continuous formula Dynamic Blood Glucose Monitoring, and sensing electrode continues automatic survey 24 hours every days hundreds of time blood glucose in human body, can understand at any time the situation of change of blood sugar.
Existing dynamic glucose sensor adopts three electrode surfaces to apply the biospecific enzymatic structure, its flexible sensitive electrode must be worked in the implant into body, this can produce certain wound to patient itself, and needs the professional to operate, and can cause certain mental pressure to the patient.
Find through the retrieval to the prior art document, Feng Li etc. are at " Biosensors and Bioelectronics " (" biosensor and bioelectronics " 26,2011,2489 pages-2494 pages) delivered the paper that is entitled as " A selective novel non-enzymeglucose amperometric biosensor based on lectin-sugar binding on thionine modified electrode " (" based on the novel non-enzymatic glucose amperometric biosensor of agglutinin sugar in conjunction with the thionine modified electrode "), propose to adopt dull and stereotyped three-electrode structure, utilize the principle that con A and glucose are combined at poly-thionine modified electrode generation biologic specificity to make glucose sensor.This sensor has high sensitivity and high stability, but this electrode can only can collect blood sugar for human body information to take the mode in blood sample or the electrode integral implant into body.
Summary of the invention
The present invention is directed to the prior art above shortcomings, a kind of micro tips array electrode for Wicresoft's Dynamic Blood Glucose Monitoring is provided, the micro tips array of each electrode of this device thrusts and rests on the shallow top layer of human body skin, can continue to survey in the body fluid blood glucose response electric current and change into blood sugar concentration parameter timing output, thereby realize the monitoring of microtrauma type continuous blood sugar, have characteristics easy and simple to handle, that wound is slight.
The present invention is achieved by the following technical solutions, the present invention includes: supporting construction and three electrode structures that are fixedly connected with it, this electrode structure is comprised of the electrode micro tips array and the electrode conducting structure that link to each other, and three electrode conducting structures all are fixedly connected with supporting construction.
Described three electrode structures respectively as working electrode, to electrode and reference electrode.
Described electrode micro tips array is comprised of several little wimble structures and finishing has the electrode function layer.
Described little wimble structure is conical structure or rectangular pyramid structure, and when little wimble structure was conical structure, little wimble structure spacing was greater than the conical structure base diameter, and when little wimble structure was the rectangular pyramid structure, little wimble structure spacing was greater than the cornerwise length in bottom.
The height of described little wimble structure is 20 μ m～200 μ m.
Described electrode conducting structure comprises: contact conductor and contact, wherein: contact conductor connection electrode micro tips array and contact.
Described contact is sensor and the extraneous conductive contact position that is connected.
Three-electrode structure of the present invention can be distributed in the same plane or according to different its relative tertiary locations of design appropriate change.The present invention can be by adjusting quantity, height and the position optimization electrode duty of micro tips array, and the shape of three kinds of conducting structures also can be adjusted arbitrarily.
The present invention makes micro tips array with the MEMS micro fabrication, and micro tips array modified with different functional coatings respectively, form working electrode micro tips array, reference electrode micro tips array, to three kinds of different functional areas of electrode micro tips array, three kinds of micro tips array have connected and composed the needed three-electrode structure of blood sugar monitoring with corresponding conducting structure respectively.When the present invention worked, the present invention was close to skin, and little spine of each electrode enters the superficial tissue liquid layer of human body skin, continue to survey in the body fluid blood glucose response electric current and changed into blood sugar concentration parameter timing output, thereby realize the Wicresoft's dynamic monitoring to blood sugar concentration.To conduct electricity that little spine enters and the mode of organizing liquid layer that rests on the shallow table of human body replaces the monitoring method of conventional dynamic blood sugar monitoring electrode integral implant into body, greatly reduce patient's misery.This electrode need not professional's operation simultaneously, and the patient can independently use, and has increased feasibility and the generalization of device.The present invention is simple in structure, and monitoring result accurately and reliably.Each electrode micro tips array is in parallel, improves the catch probability of monitoring.For the monitoring of the minor fluctuations of blood sugar concentration, this micro tips array electrode has and adds and reach compensating action, has improved the accuracy of monitoring.The specific surface area of sensor array be can realize adjusting by regulating micro-dimension needle point quantity, thereby reliability and sensitivity to blood sugar monitoring improved.Adopt simultaneously biocompatible material to make whole electrode, improved the biocompatibility of electrode and human body.The present invention is fit in batches integrated production.The present invention adopts micro fabrication, can disposablely produce in enormous quantities, and more traditional blood glucose sensor spare has the feasibility that reduces production costs.
Description of drawings
Fig. 1 is structural representation of the present invention.
Fig. 2 is embodiment 1 side-looking structural representation.
Fig. 3 is embodiment 1 structural representation, and wherein: figure (a) is the plan structure schematic diagram, and figure (b) is little wimble structure schematic diagram.
Fig. 4 is the structural representation of embodiment 2, and wherein: figure (a) is the plan structure schematic diagram, and figure (b) is little wimble structure schematic diagram.
Fig. 5 is the structural representation of embodiment 3.
The specific embodiment
Below in conjunction with accompanying drawing embodiments of the invention are elaborated, the present embodiment is implemented under take technical solution of the present invention as prerequisite, provided detailed embodiment and concrete operating process, but protection scope of the present invention is not limited to following embodiment.
Embodiment 1
Such as Fig. 1, Fig. 2 and shown in Figure 3, the present embodiment comprises: working electrode micro tips array 1, to electrode micro tips array 2, reference electrode micro tips array 3, working electrode conducting structure 4, to electrode conducting structure 5, reference electrode conducting structure 6 and supporting construction 7, wherein: working electrode micro tips array 1, to electrode micro tips array 2 and reference electrode micro tips array 3 respectively with working electrode conducting structure 4, electrode conducting structure 5 is connected connection with the reference electrode conducting structure, working electrode conducting structure 4, electrode conducting structure 5 all is fixedly connected with supporting construction 7 with reference electrode conducting structure 6.
Described working electrode micro tips array 1 is comprised of and finishing working electrode functional layer several little wimble structures 8.
Described to electrode micro tips array 2 formed by several little wimble structures 8 and finishing to the electrode function layer.
Described reference electrode micro tips array 3 is comprised of and finishing reference electrode functional layer several little wimble structures 8.
Described little wimble structure 8 is conical structure.
The base diameter of described conical structure is 10 μ m～300 μ m.
The height of described little wimble structure 8 is 20 μ m～200 μ m, and these little wimble structure 8 spacings are greater than the conical structure base diameter.
Described working electrode conducting structure 4 comprises: working electrode lead-in wire 9 and contact 10, wherein: working electrode lead-in wire 9 is connected with the contact with working electrode micro tips array 1 respectively and is connected.
Described electrode conducting structure 5 is comprised: to contact conductor 11 and contact 10, wherein: contact conductor 11 is connected with electrode micro tips array 2 is connected with the contact respectively.
Described reference electrode conducting structure 6 comprises: reference electrode lead-in wire 12 and contact 10, wherein: reference electrode lead-in wire 12 is connected with the contact with reference electrode micro tips array 3 respectively and is connected.
Described working electrode lead-in wire 9, to contact conductor 11 and reference electrode lead-in wire 12 by the joint face 13 that is connected in series successively, straight-arm 14 and vertical linking arm 15 compositions, wherein: be respectively equipped with corresponding working electrode micro tips array 1 on the joint face 13, to electrode micro tips array 2 and reference electrode micro tips array 3, vertical linking arm 15 connects with corresponding contact 10 respectively.
The straight-arm 14 of the straight-arm 14 of described reference electrode lead-in wire 12 and working electrode lead-in wire 9 is arranged at respectively the both sides to the straight-arm 14 of contact conductor 11, is 30 μ m～2mm to the spacing W of the straight-arm 14 of contact conductor 11 and the straight-arm 14 of working electrode lead-in wire 9.
The joint face 13 of the joint face 13 of described reference electrode lead-in wire 12 and working electrode lead-in wire 9 is that ring-type arc and this arc are minor arc.
Described joint face 13 to contact conductor 11 is circular.
The joint face 13 of the joint face 13 of described reference electrode lead-in wire 12 and working electrode lead-in wire 9 is that congruent figures and two joint faces 13 are symmetrical to the straight line in electrode joint face 13 centers of circle with process.
The spacing L of the joint face 13 of the joint face 13 of described reference electrode lead-in wire 12 and working electrode lead-in wire 9 is 50 μ m～10mm.
Three kinds of micro tips array 1,2,3 of this device can conduct electricity, and three kinds of micro tips array 1,2,3 material are biocompatible materials.Three kinds of micro tips array 1,2,3 employing micro fabrications form tack coat at the device surface sputtered titanium after utilizing the polymer formation micro tips array, carry out the mask etching subregion and connected and composed the needed three-electrode structure 16 of blood sugar monitoring with corresponding conducting structure respectively, be i.e. working electrode structure, reference electrode structure and to electrode structure.Each electrode structure is modified, carried out functional differentiation, realize the micro tips array conduction, working electrode functional layer and the electrode function layer adopted Pt, the reference electrode functional layer adopts Ag/AgCl.Working electrode functional layer finishing glucose oxidation catalysts if necessary, is further modified semipermeable membrane and screen layer protective layer.
Described structural material to contact conductor 11, reference electrode lead-in wire 12 and working electrode lead-in wire 9 is biocompatible materials.
Described supporting construction 7 adopts biocompatible insulant and has mechanical strength.
Three kinds of micro tips array 1 of this device, 2,3 thrust and rest on the top layer of human body skin, the degree of depth only reaches organizes liquid layer, extract the enzyme-specific catalyzed chemical reaction information of blood glucose on little sharp electrode in the tissue fluid, and with the formal output of kinetic current, thereby realize Wicresoft's dynamic monitoring to blood sugar concentration.
Such as Fig. 1 and as shown in Figure 4, the little wimble structure 8 described in the present embodiment is the rectangular pyramid structure.
The described rectangular pyramid structure base length of side is 10 μ m～300 μ m.
The spacing of described little wimble structure 8 is greater than the cornerwise length in bottom.
Such as Fig. 1 and as shown in Figure 5, the joint face 13 of the lead-in wire of the reference electrode described in the present embodiment 12 and be major arc for ring-type arc and this arc to the joint face 13 of contact conductor 11.
The joint face 13 of described working electrode lead-in wire 9 is circular.
The joint face 13 of described reference electrode lead-in wire 12, concentric to the joint face 13 of the joint face 13 of contact conductor 11 and working electrode lead-in wire 9.
The joint face 13 of described reference electrode lead-in wire 12 is arranged at the outside of the joint face 13 of working electrode lead-in wire 9, the joint face 13 of contact conductor 11 is arranged at the outside of the joint face 13 of reference electrode lead-in wire 12.
The straight-arm 14 of described working electrode lead-in wire 9 with to straight-arm 14 conllinear of contact conductor 11 and do not overlap.
The spacing W of the straight-arm 14 of the straight-arm 14 of described reference electrode lead-in wire 12 and working electrode lead-in wire 9 is 30 μ m～2mm.
Claims (1)
1. micro tips array electrode that is used for Wicresoft's Dynamic Blood Glucose Monitoring, it is characterized in that, comprise: supporting construction and three electrode structures that are fixedly connected with it, this electrode structure is comprised of the electrode micro tips array and the electrode conducting structure that link to each other, and three electrode conducting structures all are fixedly connected with supporting construction;
Described three electrode structures respectively as working electrode, to electrode and reference electrode;
Described electrode micro tips array is comprised of several little wimble structures and finishing has the electrode function layer;
Described little wimble structure is conical structure or rectangular pyramid structure;
When described little wimble structure was conical structure, little wimble structure spacing was greater than the conical structure base diameter, and when little wimble structure was the rectangular pyramid structure, little wimble structure spacing was greater than the cornerwise length in bottom;
The height of described little wimble structure is 20 μ m～200 μ m;
Described electrode conducting structure comprises: contact conductor and contact, wherein: contact conductor connection electrode micro tips array and contact;
Described working electrode, can conduct electricity and be biocompatible materials to electrode and reference electrode and make, be specially:
Form tack coat at the device surface sputtered titanium after adopting micro fabrication to utilize the polymer formation micro tips array, carry out the mask etching subregion and connected and composed the needed three-electrode structure of blood sugar monitoring with corresponding conducting structure respectively, be i.e. working electrode structure, reference electrode structure and to electrode structure;
Each electrode structure is modified, carried out functional differentiation, realize the micro tips array conduction, working electrode functional layer and the electrode function layer adopted Pt, the reference electrode functional layer adopts Ag/AgCl;
Working electrode functional layer finishing glucose oxidation catalysts; And further modify as required semipermeable membrane and screen layer protective layer;
Described structural material to contact conductor, reference electrode lead-in wire and working electrode lead-in wire is biocompatible materials.
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| CN 201110138226 CN102217939B (en) | 2011-05-26 | 2011-05-26 | Micro tip array electrode used for minimally invasive dynamic glucose monitoring |
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| CN 201110138226 CN102217939B (en) | 2011-05-26 | 2011-05-26 | Micro tip array electrode used for minimally invasive dynamic glucose monitoring |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| DK3050504T3 (en) * | 2014-10-22 | 2020-09-21 | Glutalor Medical Inc | Continuous glucose monitoring system and monitoring terminal |
| CN105963827A (en) * | 2015-11-05 | 2016-09-28 | 彭青 | Invasive type glucose therapeutic apparatus |
| CN105288774A (en) * | 2015-11-05 | 2016-02-03 | 种红侠 | Application method of invasive type blood glucose therapeutic apparatus |
| CN109781804A (en) * | 2017-11-10 | 2019-05-21 | 上海瀚联医疗技术股份有限公司 | A kind of blood sugar test module |
| CN109781821B (en) * | 2017-11-10 | 2023-10-24 | 上海瀚联医疗技术股份有限公司 | Blood sugar detector |
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| CN1865959A (en) * | 2006-06-01 | 2006-11-22 | 复旦大学 | Electrode array microchip sensor, preparation method and application therefor |
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| US20070078376A1 (en) * | 2005-09-30 | 2007-04-05 | Smith Gregory A | Functionalized microneedles transdermal drug delivery systems, devices, and methods |
| KR20080076434A (en) * | 2007-02-16 | 2008-08-20 | 박정철 | Biological information measuring apparatus and manufacturing method thereof |
| US20090099427A1 (en) * | 2007-10-12 | 2009-04-16 | Arkal Medical, Inc. | Microneedle array with diverse needle configurations |
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