CN102188557A - Application of Juncus effuses L. extract in preparing anti-tumor or angiogenesis-inhibiting medicament, health food or cosmetic - Google Patents
Application of Juncus effuses L. extract in preparing anti-tumor or angiogenesis-inhibiting medicament, health food or cosmetic Download PDFInfo
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- CN102188557A CN102188557A CN2011101112087A CN201110111208A CN102188557A CN 102188557 A CN102188557 A CN 102188557A CN 2011101112087 A CN2011101112087 A CN 2011101112087A CN 201110111208 A CN201110111208 A CN 201110111208A CN 102188557 A CN102188557 A CN 102188557A
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Abstract
The invention discloses application of Juncus effuses L. extract in preparing an anti-tumor or angiogenesis-inhibiting medicament. The invention discloses that the Juncus effuses L. extract has activities of inhibiting tumor and tumor angiogenesis for the first time, and the Juncus effuses L. extract can be used for treating or preventing diseases related to tumor and tumor angiogenesis, and also can be used in treatment for chemotherapy and/or adjuvant chemotherapy of tumor. The invention takes angiogenesis as the target spot for treating diseases, studies and explains the pharmaceutical curative effects and mechanism of the Juncus effuses L. extract, and provides a scientific basis and important information for the development of new use of the Juncus effuses L. extract and discovery of new target spots of drug action. The Juncus effuses L. extract can be applied to medicaments, health products and/or cosmetics and the like.
Description
Technical field
The invention belongs to technical field of Chinese medicines.Be specifically related to the application of a kind of Medulla junci extract in preparation antitumor or inhibition angiogenesis drug, health food or cosmetics.
Background technology
Tumor is the disease of serious threat human life health, and Chinese malignant tumor patient reached 115-1.27 ‰ before the health ministry statistical information table made eye bright, because malignant tumor and death toll occupies second of whole causes of the death.Since nearly half a century, though the treatment of malignant tumor obtains remarkable progress, also lacked ideal medicine at present, can't meet clinical needs, malignant tumor still is considered as refractory disease by people.Seek antitumor drug safely and effectively, remain focus and difficult point that various countries the world of medicine pays close attention to.
Growth of tumor, transfer rely on new vessels that nutrition and transfering channel are provided.Suppress tumor-blood-vessel growth, closely related with generation, development, infiltration and the transfer of blocking-up tumor.In recent years, people deepen continuously to the tumor-blood-vessel growth Study on Mechanism, and the medicine that many antineoplastic vasculars generate is applied clinically.This class medicine not only can be used for the treatment of most of entity tumors, can also be used for the prevention of tumor and the treatment of blood system malignant tumor, to the prevention and the treatment of the disease of other and associated angiogenesis such as diabetic renal papillary necrosis, rheumatic arthritis, psoriasis, hemangioma, atherosclerosis etc., all have certain theory and realistic meaning simultaneously.
Medulla Junci (Juncus effusus L.) is dry stem pith or the herb of rush family (Juncaceae) sharp-flowered rush (Juncus L.) plant Medulla Junci (Juncus effusus L.), another name Medulla Junci, Medulla Junci have another name called tiger's whiskers grass, lampwick, jasper grass, water lampwick, ferrum lampwick etc.Main product in Jiangsu, ground such as Sichuan, Yunnan, Guizhou.Cold nature, sweet in the mouth, light, GUIXIN, lung, small intestine meridian, the function clearing away heart-fire, diuresis, can treat vexedly few sleep, diseases such as hyperpyrexia is thirsty, the puckery pain of oliguria, infantile malnutrition, aphtha of the mouth and tongue.Studies show that at present the luxuriant and rich with fragrance constituents in the Medulla Junci has cell toxicant, antibiotic, antioxidation, antimicrobial and anti-algae activity.
Investigate through prior art, Medulla Junci (Juncus effuses L.) extract, especially Medulla Junci alcohol extraction thing, petroleum ether part and ethyl acetate extract do not appear in the newspapers to the influence and being applied in the domestic and foreign literature in preparation antitumor or inhibition tumor-blood-vessel growth medicine, health food or cosmetics of tumor and tumor-blood-vessel growth.
Summary of the invention
The object of the present invention is to provide the application of a kind of Medulla Junci (Juncus effuses L.) extract in preparation antitumor or anti-tumor angiogenesis drug, health food or cosmetics.
In order to solve these problems of the prior art, technical scheme provided by the invention is:
The invention provides the application of a kind of Medulla junci extract in preparation antitumor or inhibition angiogenesis drug.
Preferably, this extract obtains by following preparation method: get the Medulla Junci crude drug, the 3-50 that adds its weight doubly measures solvent, adopts merceration, ultrasonic, percolation or heating method to extract 1-5 time, and merge extractive liquid, except that desolvating, obtains Medulla junci extract; Described solvent is selected from a kind of or mixed solvent of water, moisture lower alcohol, lower alcohol, ethyl acetate, petroleum ether.
Preferably, the dosage form of preparation antitumor or anti-tumor angiogenesis drug is selected from injection, tablet, powder, granule, capsule, oral agents, unguentum or Emulsion.
Preferably, described tumor comprises tumor, Lymphocytic leukemia, T lymphocytoma, breast carcinoma, leukemia, osteosarcoma, melanoma, cerebral glioma, pulmonary carcinoma, gastric cancer, hepatocarcinoma, colon cancer, the chemotherapy of SW803 cell carcinoma or the auxiliary treatment of tumor that lymphoma, tumor stem cell cause.
Preferably, the keratopathy that causes of described medicine hemangioma, fibrohemangioma, neovascular glaucoma, diabetic renal papillary necrosis, retinopathy of prematurity and the retinal vein occlusion, retinal degeneration, retrolental fibroplasia, trachomatous conjunctivitis, the angiogenesis that are used for preventing or treat former or secondary to produce, climacteric macula lutea and degeneration of macula, psoriasis, the degeneration of old plate-like speckle and rheumatic arthritis, psoriasis, telangiectasis, botryomycosis hominis, wound healing suppress spot formation, atherosclerosis, seborrheic dermatitis and acne.
The present invention also provides the application of a kind of Medulla junci extract in the health food of preparation antitumor or inhibition angiogenesis.The present invention also provides the application of a kind of Medulla junci extract in the cosmetics of preparation antitumor or inhibition angiogenesis.
Technical scheme of the present invention is the application of a kind of Medulla Junci (Juncus effuses L.) extract in preparation antitumor or inhibition angiogenesis drug, health food or cosmetics.
The Medulla Junci that the present invention relates to (Juncus effuses L.) extract, this extract can extract by single solvent or mixed solvent, solvent comprises water, ethanol water, ethanol, methanol, n-butyl alcohol, petroleum ether, ethyl acetate, and selected extraction solvent comprises and is not limited to above kind (for example 95% ethanol).Extracting method can adopt merceration, ultrasonic, percolation or heating method (for example reflux, extract), but single extract, also can be multiple extraction after, merge extractive liquid, is flung to the extracting solution evaporation and is obtained.
Preferably, described antitumor or anti-tumor angiogenesis drug contain the pharmaceutically Medulla Junci of effective dose (Juncus effuses L.) extract and pharmaceutically acceptable carrier.Preferably, the dosage form of described antitumor or anti-tumor angiogenesis drug is selected from injection, tablet, powder, granule, capsule, oral agents, unguentum or Emulsion.
Preferably, described medicine is used for prevention or treatment lymphoma, tumor stem cell, T Lymphocytic leukemia, T lymphocytoma, breast carcinoma, leukemia, osteosarcoma, melanoma, cerebral glioma, pulmonary carcinoma, gastric cancer, colon cancer cell all has the obvious suppression effect.
Preferably, described medicine is used for the chemotherapy of tumor or the auxiliary treatment of tumor.
Preferably, the keratopathy that causes of described medicine hemangioma, fibrohemangioma, neovascular glaucoma, diabetic renal papillary necrosis, retinopathy of prematurity and the retinal vein occlusion, retinal degeneration, retrolental fibroplasia, trachomatous conjunctivitis, the angiogenesis that are used for preventing or treat former or secondary to produce, climacteric macula lutea and degeneration of macula, psoriasis, the degeneration of old plate-like speckle and rheumatic arthritis, psoriasis, telangiectasis, botryomycosis hominis, wound healing suppress spot formation, atherosclerosis, seborrheic dermatitis and acne.
Another object of the present invention is to provide application and a kind of Medulla Junci (Juncus effuses L.) extract the application in the cosmetics of preparation antitumor or inhibition angiogenesis of a kind of Medulla Junci (Juncus effuses L.) extract in the health food of preparation antitumor or inhibition angiogenesis.
The application of described Medulla Junci (Juncus effuses L.) extract in preparation inhibition tumor and tumor-blood-vessel growth medicine is Medulla Junci (Juncus effuses L.) extract and conventional pharmaceutical carrier and or the excipient that this inhibition tumor and tumor-blood-vessel growth medicine contain effective dose.Described extract is made into injection, tablet, powder, granule, capsule, oral agents, unguentum, cream or Emulsion.Described extract be used to prevent and treat and or treat the disease that is selected from one of the following more than at least a: cancer and or cancer metastasis, hemangioma, fibrohemangioma, neovascular glaucoma, diabetic renal papillary necrosis, retinopathy of prematurity and retinal vein occlusion, retinal degeneration, retrolental fibroplasia, trachomatous conjunctivitis, the keratopathy that angiogenesis causes, climacteric macula lutea and degeneration of macula, psoriasis, degeneration of old plate-like speckle and rheumatic arthritis, psoriasis, telangiectasis, botryomycosis hominis suppresses spot and forms in the wound healing, atherosclerosis, seborrheic dermatitis and acne.
Because this extract has the purposes of antitumor, tumor-blood-vessel growth and other and associated angiogenesis disease treatment, prevention.This extract can be used for the purposes of chemotherapy of tumors and/or auxiliary treatment.
Medulla Junci among the present invention (Juncus effuses L.) extract can prepare with conventional method.In actual needs, in Medulla Junci (Juncus effuses L.) extract, can add one or more pharmaceutically acceptable carriers.Described carrier comprises the diluent of pharmaceutical field routine, excipient, filler, binding agent, wetting agent, disintegrating agent, absorption enhancer, surfactant, absorption carrier, lubricant, emulsifying agent, osmotic pressure regulator can also add flavouring agent, sweeting agent etc. in case of necessity.
Medulla Junci among the present invention (Juncus effuses L.) extract can be routinely preparation process, use separately or prepare the medicine of operable various different dosage forms clinically, for example various ways such as injection, tablet, powder, granule, capsule, oral agents, unguentum, cream or Emulsion with other drug.
Medulla Junci among the present invention (Juncus effuses L.) extract can be applied to antitumor, tumor-blood-vessel growth and other and associated angiogenesis disease treatment, prevention, can also be used for chemotherapy of tumors and/or adjuvant chemotherapy.More specifically, the invention provides a kind of inhibition tumor of medicine, food, cosmetics, extract of angiogenesis of being used for.
With respect to scheme of the prior art, advantage of the present invention is:
The present invention finds that first Medulla Junci (Juncus effuses L.) extract has the activity that suppresses tumor and tumor-blood-vessel growth, can be used for treating or disease that prevention is relevant with tumor and tumor-blood-vessel growth, also can be used for the treatment of chemotherapy of tumors and/or adjuvant chemotherapy aspect.The present invention is dexterously with the target spot of angiogenesis as the treatment disease, research is also illustrated the medicinal curative effect and the mechanism of Medulla Junci (Juncus effuses L.) extract, developing and find that for its new purposes the new target spot of drug effect provides scientific basis and important information, is the new developing direction of Chinese medical theory.This Medulla Junci (Juncus effuses L.) extract can be used for purposes such as medicine, health product or cosmetics.
Description of drawings
Below in conjunction with drawings and Examples the present invention is further described:
Fig. 1 is the influence result of embodiment of the invention Medulla Junci alcohol extraction thing to multiple different tumor cell proliferations;
Fig. 2 is the influence result of embodiment of the invention Medulla Junci alcohol extraction thing to multiple different tumor cell proliferations;
Fig. 3 is the effect that embodiment of the invention Medulla Junci alcohol extraction thing generates the tumor cell type pipe
Fig. 4 is the effect that embodiment of the invention Medulla Junci water extract generates the tumor cell type pipe
Fig. 5 is the effect that embodiment of the invention Medulla Junci ethyl acetate extract generates the tumor cell type pipe
Fig. 6 is the effect that embodiment of the invention Medulla Junci petroleum ether part generates the tumor cell type pipe
Fig. 7 is the influence figure of embodiment of the invention Medulla Junci alcohol extraction thing to the tumor-bearing mice body weight
Fig. 8 is the influence of embodiment of the invention Medulla Junci alcohol extraction thing to the tumor-bearing mice tumor weight
Fig. 9 is the influence of embodiment of the invention Medulla Junci alcohol extraction thing to the tumor-bearing mice tumor growth
Wherein Control is the blank group; Positive matched group five fluorouracil of Fu (5-FU); 1ug/mL, 10ug/mL, 100ug/mL, 250ug/mL, 500ug/mL are Medulla Junci (the Juncus effuses L.) extract of five kinds of variable concentrations.
The specific embodiment
Below in conjunction with specific embodiment such scheme is described further.Should be understood that these embodiment are used to the present invention is described and are not limited to limit the scope of the invention.The implementation condition that adopts among the embodiment can be done further adjustment according to the condition of concrete producer, and not marked implementation condition is generally the condition in the normal experiment.
Embodiment 1:
Medulla Junci alcohol extraction thing and water extract preparation: exsiccant Medulla Junci material, crushing, 95% ethanol or the water-cooled lixiviate of 5～10 times of amounts get twice, each 24h, merge extractive liquid, filters, and concentrating under reduced pressure gets thick extractum, puts 65 ℃ of oven dry in the baking oven, promptly.
Embodiment 2:
Medulla Junci petroleum ether and ethyl acetate extract preparation: exsiccant Medulla Junci material, crushing, 95% ethanol merceration of 5～10 times of amounts extracts twice, each 24h, merge extractive liquid, filters, and concentrating under reduced pressure gets thick extractum, add the water suspendible, use petroleum ether (60～90 ℃) successively, ethyl acetate extraction.Reclaim petroleum ether layer respectively, the ethyl acetate layer extract promptly gets ligroin extraction, ethyl acetate extract.Yield is about 1%, 5% respectively.
Embodiment 3: Medulla Junci alcohol extraction thing suppresses the experiment in vitro of tumor cell proliferation
Experiment material
1 tumor cell line
People Burkitt ' s lymphoma cell Namalva and Raji, pre-neoplastic stem cell 2C4G2, PMKO102-3# and p3B11, human T lymphocyte leukaemia Jurkat, the human T lymphocyte is H9, MCF-7 MCF-7, human leukemia cell line UC-CUC, NB4 and HL-60, human osteosarcoma cell line U-2OS and SW1353, human melanoma cell is C8161, human lung carcinoma cell (lymphatic metastasis) NCI-H292, human stomach cancer cell line HGC-27, human hepatoma cell strain HepG2 and human colon cancer cell strain SW480 are that this institute laboratory is frozen.
Cell culture medium RPMI 1640 and DMEM (high sugar) are Hyclone company product.Alamarblue reagent is INVITROGEN company product.
2 are subjected to the reagent thing
Medulla Junci alcohol extraction thing (pressing the preparation of embodiment 1 method) is diluted to desired concn with dimethyl sulfoxide (DMSO) hydrotropy with RPMI 1640 or DMEM (high sugar) culture medium.
Experimental technique
1. cell culture: culture fluid is conventional cultivates with the RPMI1640 that contains volume fraction 10% calf serum and 1% pair anti-(anti-penicillin and anti-streptomycin) or DMEM (high sugar) for cell.Every 48-72h 0.25% trypsinization was expanded bottle and is gone down to posterity in 1: 2～1: 4.
(1) attached cell:
With 0.25% trypsinization attached cell, centrifugal back counting, be inoculated in 96 orifice plates with suitable concentration, cultivate 24h in 37 ℃, 5%CO2 incubator, the Medulla Junci alcohol extraction thing that adds variable concentrations respectively, in addition with simple culture fluid and without pharmaceutically-active cell as blank and negative control, establish 3 multiple holes for every group, after cultivating 46h, add AlamarBlue reagent 10ul/ hole, continue to cultivate 2h, measure OD560/OD590 under the fluorescence, calculate average suppression ratio as follows with the micropore detector.
(2) suspension cell:
Draw the suspension cell suspension, centrifugal counting, with suitable concentration with after the Medulla Junci alcohol extraction thing of variable concentrations mixes, be inoculated in 96 orifice plates, respectively with simple culture fluid and without pharmaceutically-active cell as blank and negative control, establish 3 multiple holes, 37 ℃, 5%CO for every group
2After cultivating 46h in the incubator, add AlamarBlue reagent 10ul/ hole, continue to cultivate 2h, measure OD560/OD590 under the fluorescence, calculate average suppression ratio by above-mentioned formula with the micropore detector.
Experimental result
The influence that Medulla Junci alcohol extraction thing is bred kinds of tumor cells: Medulla Junci alcohol extraction thing shows inhibited proliferation preferably to kinds of tumor cells, and raising along with drug level, the kinds of tumor cells inhibited proliferation is correspondingly strengthened, and each drug level group comparing difference has statistical significance (P＜0.05).(see Table 1-2, Fig. 1-2)
Table 1 Medulla Junci alcohol extraction thing is to the influence (1) of kinds of tumor cells propagation
Table 2 Medulla Junci alcohol extraction thing is to the influence (2) of kinds of tumor cells propagation
Embodiment 4: Medulla junci extract is to the influence of tumor cell in vitro angiogenesis
Experiment material
1 tumor cell line SW872 is that this institute laboratory is frozen
2 are subjected to reagent thing Medulla Junci alcohol extraction thing, water extract, and petroleum ether part, ethyl acetate extract is with embodiment 1 and example 2
3 positive control drug 5-fluorouracil (5-FU) are SIGMA company product, and it is standby to be mixed with 5mM with PBS.
Experimental technique
Tumor cell line SW872 placed the DMEM culture fluid that contains 10% hyclone in 37 ℃, 5%CO
2Incubator is cultivated.The trophophase cell of taking the logarithm is with 4 * 10
4/ mL cell kind is put in 37 ℃, 5%CO in being covered with fibrinous 24 orifice plates of one deck in advance
2Incubator was cultivated 24 hours.Behind the 24h, add variable concentrations Medulla Junci alcohol extraction thing,,, behind the cultivation 36h, carefully remove supernatant, dye, choose every hole representative region afterwards and take pictures with auspicious Ji Shi dye liquor with the positive contrast of 5uM 5-Fu with the negative contrast of blank culture fluid.
Experimental result
Tumor cell SW872 can form the class capillary structure external, Medulla Junci alcohol extraction thing, Medulla Junci water extract, Medulla Junci petroleum ether part and Medulla Junci ethyl acetate extract show good inhibitory effect to the type pipe generation of tumor cell, and raising along with drug level, the kinds of tumor cells inhibited proliferation is correspondingly strengthened, and wherein the action effect of Medulla Junci alcohol extraction thing is better than water extract.(seeing Fig. 3-6)
Embodiment 5: Medulla Junci alcohol extraction thing is to the curative effect of SW872 tumor-bearing mice
1 laboratory animal:
Strain: Kunming mouse is male
Source: University Of Suzhou's medical college Experimental Animal Center
The quality certification: laboratory animal production licence number: XCYK (Soviet Union) 2002-0008, laboratory animal occupancy permit number: SYXK (Soviet Union) 2002-0037.
Body weight: 18-22g
Every treated animal number: 8
2 tumor cell line SW872 are that this institute laboratory is frozen
3 are subjected to reagent thing Medulla Junci alcohol extraction thing (pressing the preparation of embodiment 1 method) to use soil temperature-80 hydrotropy, and normal saline is diluted to desired concn
4 experimental techniques
24 of Male Kunming strain mice, body weight 18-22g.Be divided into three groups at random, 8 every group: matched group, model group and Medulla Junci alcohol extraction thing group.With ready SW872 tumor cell suspension with 5 * 10
6/ only being inoculated in model group and Medulla Junci alcohol extraction thing group mouse back is subcutaneous, control group mice is the inoculated tumour cell not.Began gastric infusion on the same day of inoculated tumour cell, Medulla Junci alcohol extraction thing group gavages 1000mg/kg/d every day, and model group and matched group gavage isopyknic normal saline, and gavage once every day.Dislocation method was put to death mice in the 21st day, and the taking-up tumor is taken pictures and write down tumor weight, calculates tumour inhibiting rate then as follows: tumor control rate=[the average tumor of the average tumor weight/model group of 1-administration group is heavy] * 100%.
Statistical analysis:
Adopt SPSS 11.5 statistical softwares to carry out statistical analysis.Every group of experiment repeats 3 times, relatively adopts the independent sample t check between group.
4 experimental results
Tumor-bearing mice is through gavaging administration after 21 days, Medulla Junci alcohol extraction thing with respect to the model group tumour inhibiting rate up to 68.1%.Compare with model group, tumor-bearing mice body weight after the intervention of Medulla Junci alcohol extraction thing does not have significant change, but tumor growth obviously reduces, tumor weight and gross tumor volume obviously reduce (P＞0.01) and (see Table 3-4, Fig. 7-9), prompting Medulla Junci ethanol extract has the good restraining effect to the tumor-bearing mice growth of tumor.
Table 3 Medulla Junci alcohol extraction thing to the influence of tumor-bearing mice body weight (
N=8)
Table 4 Medulla Junci alcohol extraction thing to the influence of tumor-bearing mice tumor weight (
N=8)
Claims (7)
1. the application of Medulla junci extract in preparation antitumor or inhibition angiogenesis drug.
2. the application of Medulla junci extract according to claim 1 in preparation antitumor or inhibition angiogenesis drug, it is characterized in that this extract obtains by following preparation method: get the Medulla Junci crude drug, the 3-50 that adds its weight doubly measures solvent, adopt merceration, ultrasonic, percolation or heating method to extract 1-5 time, merge extractive liquid,, remove and desolvate, obtain Medulla junci extract; Described solvent is selected from a kind of or mixed solvent of water, moisture lower alcohol, lower alcohol, ethyl acetate, petroleum ether.
3. the application of Medulla junci extract according to claim 1 in preparation antitumor or inhibition angiogenesis drug, it is characterized in that the dosage form for preparing antitumor or anti-tumor angiogenesis drug is selected from injection, tablet, powder, granule, capsule, oral agents, unguentum or Emulsion.
4. the application of Medulla junci extract according to claim 3 in preparation antitumor or inhibition angiogenesis drug, wherein said tumor comprises tumor, Lymphocytic leukemia, T lymphocytoma, breast carcinoma, leukemia, osteosarcoma, melanoma, cerebral glioma, pulmonary carcinoma, gastric cancer, hepatocarcinoma, colon cancer, the chemotherapy of SW803 cell carcinoma or the auxiliary treatment of tumor that lymphoma, tumor stem cell cause.
5. Medulla junci extract according to claim 1 is at the preparation antitumor or suppress application in the angiogenesis drug, it is characterized in that described medicine is used to prevent or treats the hemangioma that former or secondary produce, fibrohemangioma, neovascular glaucoma, diabetic renal papillary necrosis, retinopathy of prematurity and retinal vein occlusion, retinal degeneration, retrolental fibroplasia, trachomatous conjunctivitis, the keratopathy that angiogenesis causes, climacteric macula lutea and degeneration of macula, psoriasis, old plate-like speckle degeneration and rheumatic arthritis, psoriasis, telangiectasis, botryomycosis hominis, suppressing spot in the wound healing forms, atherosclerosis, seborrheic dermatitis and acne.
6. the application of Medulla junci extract in the health food of preparation antitumor or inhibition angiogenesis.
7. the application of Medulla junci extract in the cosmetics of preparation antitumor or inhibition angiogenesis.
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| CN104432239A (en) * | 2014-12-23 | 2015-03-25 | 施东德 | Sturgeon ball food |
| CN104473234A (en) * | 2014-12-23 | 2015-04-01 | 潘建杰 | Health-care bighead carp ball food |
| CN104585793A (en) * | 2014-12-23 | 2015-05-06 | 施东德 | Tilapia ball food |
| CN104922317A (en) * | 2014-03-21 | 2015-09-23 | 北京中医药大学 | Juncus effususl phenanthrene effective part and preparation method and use thereof |
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| CN101199359A (en) * | 2006-12-12 | 2008-06-18 | 株式会社Sfc | Rush juice powder |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101199359A (en) * | 2006-12-12 | 2008-06-18 | 株式会社Sfc | Rush juice powder |
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Cited By (5)
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| CN104922317A (en) * | 2014-03-21 | 2015-09-23 | 北京中医药大学 | Juncus effususl phenanthrene effective part and preparation method and use thereof |
| CN104922317B (en) * | 2014-03-21 | 2020-09-25 | 北京中医药大学 | Rush phenanthrene effective part and preparation method and application thereof |
| CN104432239A (en) * | 2014-12-23 | 2015-03-25 | 施东德 | Sturgeon ball food |
| CN104473234A (en) * | 2014-12-23 | 2015-04-01 | 潘建杰 | Health-care bighead carp ball food |
| CN104585793A (en) * | 2014-12-23 | 2015-05-06 | 施东德 | Tilapia ball food |
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Application publication date: 20110921 |