CN102188368A - Preparation technology of compound sodium chloride eye drop solution - Google Patents
Preparation technology of compound sodium chloride eye drop solution Download PDFInfo
- Publication number
- CN102188368A CN102188368A CN 201110094979 CN201110094979A CN102188368A CN 102188368 A CN102188368 A CN 102188368A CN 201110094979 CN201110094979 CN 201110094979 CN 201110094979 A CN201110094979 A CN 201110094979A CN 102188368 A CN102188368 A CN 102188368A
- Authority
- CN
- China
- Prior art keywords
- eye drop
- sodium chloride
- drop solution
- hydroxypropyl methylcellulose
- sterilization
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a preparation method of a compound sodium chloride eye drop solution. The method comprises the following steps: 1. weighing prescribed doses of sodium chloride, potassium chloride and ethylparaben, dissolving the sodium chloride, potassium chloride and ethylparaben in a proper amount of hot injection water, adding hydroxypropyl methylcellulose after complete dissolution thereof, stirring under a heating condition to completely hydrate the hydroxypropyl methylcellulose, filtering after complete dissolution of the hydroxypropyl methylcellulose, adding injection water again in a certain amount, adjusting a pH to 6.5-8.5 with a sodium bicarbonate solution, and dispensing the solution; 2. carrying out low temperature fractional repeated sterilization, wherein an eye dropper does not deform after the sterilization, and amount and pH of the eye drop solution remain the same, besides the eye drop solution is clear and qualified, so as to satisfy requirements hygienically. The invention has the advantages that the hydroxypropyl methylcellulose in the compound sodium chloride eye drop solution can adhere to a cornea epithollium surface for a long time to play a role of water supplement and protection, and also is in conformity with an osmotic pressure, a pH viscosity and an electrolyte concentration of human tear; besides, in a production process of the compound sodium chloride eye drop solution, a preparation and filling process is simple, and the sterilization method is easy for operation. In addition, quality of the compound sodium chloride eye drop solution reaches national quality standards according to detections.
Description
Technical field
The present invention relates to a kind of preparation method of eye drop, particularly a kind of preparation method of safe, efficient, comfortable compound NaCl eye drop belongs to technical field of pharmaceuticals.
Background technology
The compound NaCl eye drop is a sodium chloride; the compound preparation of potassium chloride; and by an amount of hydroxypropyl methylcellulose adjusting viscosity; in recent years; it is the measure of mainly treating that keratoconjunctivitis sicca (also claiming xerophthalmia) patient is replenished the artificial tears; its mechanism is to utilize various polymers to make eye drop; the long more corneal epithelium surface that sticks to; can play eyes and keep the skin wet; moistening eye surface; produce mucus; water absorption solution is covered in the eye surface; thereby play protection eyes and the effect that improves patient symptom, it can effectively alleviate and treat xerophthalmia.
Contain an amount of hydroxypropyl methylcellulose in the compound NaCl eye drop, its lubrication is good, and action time is lasting, can make eye more comfortable.The refractive index of this product is similar to eye cornea in addition, does not affect one's power of vision, thereby can prevent blurred vision.
Summary of the invention
Technical problem at above-mentioned existence the objective of the invention is: the preparation method that has proposed a kind of safe, efficient, comfortable compound NaCl eye drop.
Technical solution of the present invention is achieved in that a kind of preparation method of compound NaCl eye drop, comprises following steps:
One, sodium chloride, potassium chloride and the ethyl hydroxybenzoate that takes by weighing recipe quantity dissolves in an amount of hot water for injection, after treating dissolving fully, add hydroxypropyl methylcellulose, heated condition stirs down and makes its complete hydration, treat that it dissolves after-filtration fully, add water for injection to quantitative, sodium bicarbonate solution is regulated pH value between 6.5～8.5, packing;
Two, intermittently sterilization repeatedly of low temperature, sterilization back eye dropper is not out of shape, the content of eye drop and PH no change, clear and bright qualified, hygiology meets the requirements.
Because the utilization of technique scheme, the present invention compared with prior art has following advantage:
(1) but in the compound NaCl eye drop hydroxypropyl methylcellulose long period stick to the corneal epithelium surface, work to keep the skin wet and protective effect, and meet the osmotic pressure of human body tear, pH viscosity and electrolyte concentration etc.
(2) because hydroxypropyl methylcellulose viscosity is bigger, solubility is relatively poor, can't make finished product reach hygienic requirements by the aseptic filtration method, and because interior packaging material material is too high to temperature requirement, can't pass through flowing steam sterilization, low temperature that this technology is taked is sterilization repeatedly intermittently, has solved above problem.
(3) the compound NaCl eye drop in process of production, the preparation embedding simple and easy, sterilizing methods is easy to operate, after testing, quality meets state quality standard.
The specific embodiment
The preparation method of a kind of compound NaCl eye drop of the present invention comprises following steps:
One, sodium chloride, potassium chloride and the ethyl hydroxybenzoate that takes by weighing recipe quantity dissolves in an amount of hot water for injection, after treating dissolving fully, add hydroxypropyl methylcellulose, heated condition stirs down and makes its complete hydration, treat that it dissolves after-filtration fully, add water for injection to quantitative, sodium bicarbonate solution is regulated pH value between 6.5～8.5, packing;
Two, intermittently sterilization repeatedly of low temperature, sterilization back eye dropper is not out of shape, the content of eye drop and PH no change, clear and bright qualified, hygiology meets the requirements.
Because the utilization of technique scheme, the present invention compared with prior art has following advantage:
(1) but in the compound NaCl eye drop hydroxypropyl methylcellulose long period stick to the corneal epithelium surface, work to keep the skin wet and protective effect, and meet the osmotic pressure of human body tear, pH viscosity and electrolyte concentration etc.
(2) because hydroxypropyl methylcellulose viscosity is bigger, solubility is relatively poor, can't make finished product reach hygienic requirements by the aseptic filtration method, and because interior packaging material material is too high to temperature requirement, can't pass through flowing steam sterilization, low temperature that this technology is taked is sterilization repeatedly intermittently, has solved above problem.
(3) the compound NaCl eye drop in process of production, the preparation embedding simple and easy, sterilizing methods is easy to operate, after testing, quality meets state quality standard.
The foregoing description only is explanation technical conceive of the present invention and characteristics; its purpose is to allow the personage that is familiar with this technology can understand content of the present invention and is implemented; can not limit protection scope of the present invention with this; all equivalences that spirit is done according to the present invention change or modify, and all should be encompassed in protection scope of the present invention.
Claims (1)
1. the preparation method of a compound NaCl eye drop comprises following steps:
One, sodium chloride, potassium chloride and the ethyl hydroxybenzoate that takes by weighing recipe quantity dissolves in an amount of hot water for injection, after treating dissolving fully, add hydroxypropyl methylcellulose, heated condition stirs down and makes its complete hydration, treat that it dissolves after-filtration fully, add water for injection to quantitative, sodium bicarbonate solution is regulated pH value between 6.5～8.5, packing;
Two, intermittently sterilization repeatedly of low temperature, sterilization back eye dropper is not out of shape, the content of eye drop and PH no change, clear and bright qualified, hygiology meets the requirements.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110094979 CN102188368A (en) | 2011-04-15 | 2011-04-15 | Preparation technology of compound sodium chloride eye drop solution |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110094979 CN102188368A (en) | 2011-04-15 | 2011-04-15 | Preparation technology of compound sodium chloride eye drop solution |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102188368A true CN102188368A (en) | 2011-09-21 |
Family
ID=44597810
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201110094979 Pending CN102188368A (en) | 2011-04-15 | 2011-04-15 | Preparation technology of compound sodium chloride eye drop solution |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102188368A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102961399A (en) * | 2012-11-28 | 2013-03-13 | 宁夏康亚药业有限公司 | Sodium chloride eye drops and preparation method thereof |
| CN103083354A (en) * | 2011-11-01 | 2013-05-08 | 苏州太湖美药业有限公司 | Compound sodium chloride eye drops |
| CN115093486A (en) * | 2022-07-13 | 2022-09-23 | 上海卫康光学眼镜有限公司 | Hydroxypropyl methylcellulose HPMC (hydroxy propyl methyl cellulose) dissolving method |
-
2011
- 2011-04-15 CN CN 201110094979 patent/CN102188368A/en active Pending
Non-Patent Citations (3)
| Title |
|---|
| 《中华人民共和国药典2005版(二部)》 20050131 国家药典委员会 复方氯化钠滴眼液 436 1 , * |
| 《佳木斯医学院学报》 19920831 王萍等 爱茂尔注射液采用间歇低温灭菌工艺探讨 81-82 1 第15卷, 第4期 * |
| 《现代应用药学》 19940228 王海峰灯 2％羟丙基甲基纤维素滴眼剂的制备 49-50 1 第11卷, 第1期 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103083354A (en) * | 2011-11-01 | 2013-05-08 | 苏州太湖美药业有限公司 | Compound sodium chloride eye drops |
| CN102961399A (en) * | 2012-11-28 | 2013-03-13 | 宁夏康亚药业有限公司 | Sodium chloride eye drops and preparation method thereof |
| CN102961399B (en) * | 2012-11-28 | 2014-09-10 | 宁夏康亚药业有限公司 | Sodium chloride eye drops and preparation method thereof |
| CN115093486A (en) * | 2022-07-13 | 2022-09-23 | 上海卫康光学眼镜有限公司 | Hydroxypropyl methylcellulose HPMC (hydroxy propyl methyl cellulose) dissolving method |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101606900B (en) | Whitening facial mask containing cubilose extracting solution | |
| CN105343739B (en) | A kind of ointment that treating myopia and preparation method | |
| CN102504942B (en) | Process for preparing high quality tea oil | |
| CN103113986B (en) | Preparation method of high-quality tea oil | |
| CN103417733B (en) | A kind of pharmaceutical composition of alleviating asthenopia | |
| CN102188368A (en) | Preparation technology of compound sodium chloride eye drop solution | |
| CN1823754A (en) | Sodium bromophenolate eye drops and its preparation method | |
| CN109045063A (en) | A kind of injecting temperature sensitive in situ response water soluble chitosan composite hydrogel and its preparation method and application for lacrimal passage embolism | |
| CN106635533A (en) | Natural whitening cold soap and manufacturing method thereof | |
| CN104824510A (en) | Health food with eyesight protection function | |
| CN104824675A (en) | Eyesight improving lutein capsule | |
| CN109908199A (en) | A kind of chamomile collyrium | |
| CN103877067B (en) | A kind of Capsules controlling disintegration and preparation method thereof | |
| CN111803441A (en) | Sodium hyaluronate eye drops containing 0.01% atropine and preparation method thereof | |
| CN102961399B (en) | Sodium chloride eye drops and preparation method thereof | |
| CN102743309A (en) | Hydrating facial mask | |
| CN108514600A (en) | A kind of eye sticker and preparation method thereof | |
| CN108260787A (en) | Eyeshield health-care fruit jelly and its manufacturing method | |
| CN104000745B (en) | Spraying cleansing water without irritating to eyes and preparing method of spraying cleansing water | |
| CN104173385A (en) | Honey eyedrop treating xerophthalmia and preparation method thereof | |
| CN104824644A (en) | Food suitable for vision protection | |
| CN110974674A (en) | Eye washing device and eye washing method | |
| CN104546692A (en) | Recombinant calf alkaline fibroblast growth factor ophthalmic gel | |
| CN105769920A (en) | Pearl clear-sighted eye drops and preparation method | |
| CN110115382A (en) | A kind of bright soft capsule of benefit that can alleviate visual fatigue and its production method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20110921 |