CN102166377A - Composition, preparation method and use method of lubricating hydrophilic coating for medical catheter - Google Patents
Composition, preparation method and use method of lubricating hydrophilic coating for medical catheter Download PDFInfo
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- CN102166377A CN102166377A CN2011100053325A CN201110005332A CN102166377A CN 102166377 A CN102166377 A CN 102166377A CN 2011100053325 A CN2011100053325 A CN 2011100053325A CN 201110005332 A CN201110005332 A CN 201110005332A CN 102166377 A CN102166377 A CN 102166377A
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Abstract
The invention relates to a composition of a lubricating hydrophilic coating for a medical catheter. The composition comprises the following components in weight ratio: 15-40% of acetal polymer, 30-70% of hydrophilic polymer and 15-30% of citrate plasticizer, wherein the molecular weight of the hydrophilic polymer is 100,000-1,500,000. The composition and an organic solvent are mixed and fully stirred, and a uniform hydrophilic coating solution is formed after complete dissolution. The medical catheter is immersed in the hydrophilic coating solution or sprayed with the hydrophilic coating solution, and the catheter with the hydrophilic coating is air-dried and dried so that a stable coating is formed on the surface of the medical catheter. The coating does not have lubricating property in the dry state but has good lubricating property and wear resistance while in contact with human blood, so that the pain of patients in surgery can be greatly relieved. In addition, the coating prepared by the invention can also be widely applied to blood vascular intervention type catheters.
Description
Technical field
The present invention relates to a kind of hydrophilic coating, compositions, preparation method and the using method of the lubricated hydrophilic coating of especially a kind of medical catheter.
Background technology
Get involved the development of class medical apparatus and instruments along with blood vessel; increasing medical catheter has appearred now; as microtubular; guiding catheter; the delivery sheath of various supports or thromboembolism protector; these conduits all are need enter in the various blood vessels of human body; for the blood compatibility that improves the medical catheter that this class contacts with blood and reduce the resistance that conduit is walked in blood vessel; be necessary the surface of this class conduit is carried out the modification of hydrophilic coating; a large amount of clinical effectivenesses show; the medical catheter of modifying through hydrophilic coating both can alleviate patient's misery, and was very convenient to doctor's operation technique simultaneously.
Announced both at home and abroad much about the patent of hydrophilic coating, for example, set forth the method that a kind of preparation can reduce the hydrophilic coating of medical instruments mantle friction among the European patent 0586324A1, in the hydrophilic coating except containing binding property polymer, hydrophilic polymeric beyond the region of objective existence, also added a kind of inorganic compound that coating penetration is pressed that improves, as NaCl, the defective of this coating is that NaCl is difficult to be dissolved in the organic solvent when preparation coating liquid, can only exist with the form of suspension, the coating that finally obtains can be more coarse; A kind of hydrophilic coating that can be used for medical apparatus and instruments is disclosed among the United States Patent (USP) 6221425B1, at first be coated with the polymerisable monomer solution of one deck on the apparatus surface, polymerization under certain condition forms the bottoming polymer, and then be coated with the last layer hydrophilic polymer, obtain hydrophilic coating after the dried, the defective of this method is that operating procedure is more loaded down with trivial details, and forms the residual monomer that some are difficult for removal easily, the safety that influence is used; Chinese patent 03121883.0 discloses a kind of medical lubricating fluid that the medical catheter surface reduces frictional resistance that is coated on, lubricating fluid is made up of cellulose esters base polymer, adhesiveness polymer, plasticizer, hydrophilic polymer, this coating process also is to be finished by two steps, and, cause the instability of coating because the adhesive force of cellulose esters base polymer and some macromolecule matrix is less.
Summary of the invention
At the weak point that exists in the problems referred to above, the invention provides a kind of compositions, preparation method and using method that can realize bio-safety, lubricity height, stablize the lubricated hydrophilic coating of attrition resistant medical catheter.
For achieving the above object, the invention provides the compositions of the lubricated hydrophilic coating of a kind of medical catheter, said composition is made up of acetals polymer, hydrophilic polymer and citric acid ester plasticiser, and the weight proportion scope of said components is acetals polymer 15～40%, hydrophilic polymer 30～70%, citric acid ester plasticiser 15～30%; The molecular weight of described hydrophilic polymer is 100000～1500000.
Described acetals polymer is a polyvinyl butyral resin; Described hydrophilic polymer is one or more in Polyethylene Glycol, polyvinylpyrrolidone, the polyethylene glycol oxide; Described citric acid ester plasticiser is a kind of in triethyl citrate, tributyl citrate, the tributyl 2-acetylcitrate.
The present invention also provides the preparation of compositions method of the lubricated hydrophilic coating of a kind of medical catheter simultaneously, it mixes the back with described compositions and fully stirs the hydrophilic coating solution for the treatment of to dissolve fully back formation homogeneous with organic solvent, the concentration range of hydrophilic coating solution is 2～6%.Described organic solvent is N, one or more in dinethylformamide, oxolane, ethyl acetate, butyl acetate, butanone, dehydrated alcohol, isopropyl alcohol, acetone, chloroform, the toluene.
The present invention also provides the using method of the compositions of the lubricated hydrophilic coating of a kind of medical catheter simultaneously, and the hydrophilic coating solution that the nylon conduit is immersed in after the preparation took out after 1～2 minute, dried processing then at normal temperatures, again medical catheter was carried out drying.To the needed temperature of medical catheter dried is 50～80 ℃, and the dry needed time is 10～60 minutes.In addition, hydrophilic coating solution spraying after can also will preparing by spraying equipment is on the medical catheter surface, thereby be formed with uniform coating on the surface of medical catheter, the coating after spraying need be dried processing at normal temperatures, again medical catheter is carried out drying.
Compared with prior art, the present invention has the following advantages:
The compositions of the lubricated hydrophilic coating of medical catheter provided by the invention, said composition is made up of acetals polymer, hydrophilic polymer and citric acid ester plasticiser, and the weight proportion scope of said components is acetals polymer 15～40%, hydrophilic polymer 30～70%, citric acid ester plasticiser 15～30%; The molecular weight of hydrophilic polymer is 100000～1500000.Above-mentioned composition is mixed the back fully stir with organic solvent, treat to dissolve fully the hydrophilic coating solution that the back forms homogeneous.Be immersed in medical catheter behind the hydrophilic coating solution or adopt the method for spraying, the medical catheter that has hydrophilic coating carries out dried more at a certain temperature after room temperature is dried, thereby forms stable coating on the surface of medical catheter.The present invention can realize bio-safety, lubricity height, stablize attrition resistant hydrophilic coating, and cost is lower, and method is simple.This coating does not have lubricity under drying regime, but with have good lubricity and wearability after blood of human body contacts, can reduce the misery of patient in operation greatly, and the selected polymer of this coating is all nontoxic to human body, the biological safety height.In addition, coatings prepared of the present invention can also be widely used in blood vessel and get involved the class conduit, as microtubular, guiding catheter, stent delivery sheath pipe etc.
The specific embodiment
The invention provides the compositions of the lubricated hydrophilic coating of a kind of medical catheter, said composition is made up of acetals polymer, hydrophilic polymer and citric acid ester plasticiser, and the weight proportion scope of said components is acetals polymer 15～40%, hydrophilic polymer 30～70%, citric acid ester plasticiser 15～30%; The molecular weight of hydrophilic polymer is 100000～1500000.
The acetals polymer is a polyvinyl butyral resin; Hydrophilic polymer is one or more in Polyethylene Glycol, polyvinylpyrrolidone, the polyethylene glycol oxide; The citric acid ester plasticiser is a kind of in triethyl citrate, tributyl citrate, the tributyl 2-acetylcitrate.
The present invention also provides the preparation of compositions method of the lubricated hydrophilic coating of a kind of medical catheter simultaneously, it mixes the back with compositions and fully stirs the hydrophilic coating solution for the treatment of to dissolve fully back formation homogeneous with organic solvent, the concentration range of hydrophilic coating solution is 2～6%.Wherein, organic solvent is N, one or more in dinethylformamide, oxolane, ethyl acetate, butyl acetate, butanone, dehydrated alcohol, isopropyl alcohol, acetone, chloroform, the toluene.
The present invention also provides the using method of the compositions of the lubricated hydrophilic coating of a kind of medical catheter simultaneously, the hydrophilic coating solution that medical catheter is immersed in preparation takes out or adopts the method that sprays after 1～2 minute, dry at normal temperatures then, again conduit is carried out dried.Needed temperature is 50～80 ℃ during to the medical catheter dried, and the dry needed time is 10～60 minutes.
Embodiment one
The invention provides the compositions of the lubricated hydrophilic coating of a kind of medical catheter, said composition is made up of acetals polymer, hydrophilic polymer and citric acid ester plasticiser, and the weight proportion scope of said components is acetals polymer 15%, hydrophilic polymer 70%, citric acid ester plasticiser 15%; The molecular weight of hydrophilic polymer is 100000.Wherein, the acetals polymer is a polyvinyl butyral resin; Hydrophilic polymer is one or more in Polyethylene Glycol, polyvinylpyrrolidone, the polyethylene glycol oxide; The citric acid ester plasticiser is a kind of in triethyl citrate, tributyl citrate, the tributyl 2-acetylcitrate.
Above-mentioned composition is mixed the back fully stir the hydrophilic coating solution for the treatment of to dissolve fully back formation homogeneous with organic solvent, the concentration range of hydrophilic coating solution is 2%.Wherein, organic solvent is N, one or more in dinethylformamide, oxolane, ethyl acetate, butyl acetate, butanone, dehydrated alcohol, isopropyl alcohol, acetone, chloroform, the toluene.This organic solvent is by the butanone of 20ml, the dehydrated alcohol of 50ml, the ethyl acetate of 15ml and the N of 15ml, and dinethylformamide is mixed and made into.
The hydrophilic coating solution that medical catheter is immersed in after the preparation took out after 1 minute, dried at normal temperatures earlier then, again dried was carried out on the surface of medical catheter.Wherein, needed temperature is 50 ℃ during to the medical catheter drying, and the dry needed time is 10 minutes.
The material of medical catheter matrix is nylon, polyurethane, polyethylene, polrvinyl chloride, Pebax etc.
In addition, hydrophilic coating solution spraying after can also will preparing by spraying equipment is on the medical catheter surface, thereby form uniform coating on the surface of medical catheter, the coating after spraying need be dried processing at normal temperatures, again medical catheter is carried out drying.
Embodiment two
The invention provides the compositions of the lubricated hydrophilic coating of a kind of medical catheter, said composition is made up of acetals polymer, hydrophilic polymer and citric acid ester plasticiser, and the weight proportion scope of said components is acetals polymer 20%～35%, hydrophilic polymer 40%～60%, citric acid ester plasticiser 20%～30%; The molecular weight of hydrophilic polymer is 900000.Wherein, the acetals polymer is a polyvinyl butyral resin; Hydrophilic polymer is one or more in Polyethylene Glycol, polyvinylpyrrolidone, the polyethylene glycol oxide; The citric acid ester plasticiser is a kind of in triethyl citrate, tributyl citrate, the tributyl 2-acetylcitrate.
Above-mentioned composition is mixed the back fully stir the hydrophilic coating solution for the treatment of to dissolve fully back formation homogeneous with organic solvent, the concentration range of hydrophilic coating solution is 3%.Wherein, organic solvent is N, one or more in dinethylformamide, oxolane, ethyl acetate, butyl acetate, butanone, dehydrated alcohol, isopropyl alcohol, acetone, chloroform, the toluene.This organic solution is by the butanone of 20ml, the dehydrated alcohol of 45ml, the ethyl acetate of 10ml, the acetone of 10ml, the N of 15ml, and dinethylformamide is mixed and made into.
The hydrophilic coating solution that medical catheter is immersed in after the preparation took out after 1 minute, dried at normal temperatures earlier then, again dried was carried out on the surface of medical catheter.Wherein, needed temperature is 60 ℃ during to the medical catheter drying, and the dry needed time is 60 minutes.
The material of medical catheter matrix is nylon, polyurethane, polyethylene, polrvinyl chloride, Pebax etc.
In addition, hydrophilic coating solution spraying after can also will preparing by spraying equipment is on the medical catheter surface, thereby form uniform coating on the surface of medical catheter, the coating after spraying need be dried processing at normal temperatures, again medical catheter is carried out drying.
Embodiment three
The invention provides the compositions of the lubricated hydrophilic coating of a kind of medical catheter, said composition is made up of acetals polymer, hydrophilic polymer and citric acid ester plasticiser, and the weight proportion scope of said components is acetals polymer 20%～30%, hydrophilic polymer 40%～60%, citric acid ester plasticiser 20%～25%; The molecular weight of hydrophilic polymer is 400000.Wherein, the acetals polymer is a polyvinyl butyral resin; Hydrophilic polymer is one or more in Polyethylene Glycol, polyvinylpyrrolidone, the polyethylene glycol oxide; The citric acid ester plasticiser is a kind of in triethyl citrate, tributyl citrate, the tributyl 2-acetylcitrate.
Above-mentioned composition is mixed the back fully stir the hydrophilic coating solution for the treatment of to dissolve fully back formation homogeneous with organic solvent, the concentration range of hydrophilic coating solution is 4%.Wherein, organic solvent is N, one or more in dinethylformamide, oxolane, ethyl acetate, butyl acetate, butanone, dehydrated alcohol, isopropyl alcohol, acetone, chloroform, the toluene.This organic solution is by the butanone of 25ml, the dehydrated alcohol of 65ml, the butyl acetate of 20ml, the N of 20ml, and dinethylformamide is mixed and made into.
The hydrophilic coating solution that medical catheter is immersed in after the preparation took out after 1 minute, dried at normal temperatures earlier then, again dried was carried out on the surface of medical catheter.Wherein, needed temperature is 60 ℃ during to the medical catheter drying, and the dry needed time is 30 minutes.
The material of medical catheter matrix is nylon, polyurethane, polyethylene, polrvinyl chloride, Pebax etc.
In addition, hydrophilic coating solution spraying after can also will preparing by spraying equipment is on the medical catheter surface, thereby form uniform coating on the surface of medical catheter, the coating after spraying need be dried processing at normal temperatures, again medical catheter is carried out drying.
Embodiment four
The invention provides the compositions of the lubricated hydrophilic coating of a kind of medical catheter, said composition is made up of acetals polymer, hydrophilic polymer and citric acid ester plasticiser, and the weight proportion scope of said components is acetals polymer 25%, hydrophilic polymer 50%, citric acid ester plasticiser 25%; The molecular weight of hydrophilic polymer is 600000.Wherein, the acetals polymer is a polyvinyl butyral resin; Hydrophilic polymer is one or more in Polyethylene Glycol, polyvinylpyrrolidone, the polyethylene glycol oxide; The citric acid ester plasticiser is a kind of in triethyl citrate, tributyl citrate, the tributyl 2-acetylcitrate.
Above-mentioned composition is mixed the back fully stir the hydrophilic coating solution for the treatment of to dissolve fully back formation homogeneous with organic solvent, the concentration range of hydrophilic coating solution is 5%.Wherein, organic solvent is N, one or more in dinethylformamide, oxolane, ethyl acetate, butyl acetate, butanone, dehydrated alcohol, isopropyl alcohol, acetone, chloroform, the toluene.This organic solution is by the butanone of 25ml, the dehydrated alcohol of 70ml, the butyl acetate of 20ml, the N of 20ml, and dinethylformamide is mixed and made into.
The hydrophilic coating solution that medical catheter is immersed in after the preparation took out after 1 minute, dried at normal temperatures earlier then, again dried was carried out on the surface of medical catheter.Wherein, needed temperature is 55 ℃ during to the medical catheter drying, and the dry needed time is 60 minutes.
The material of medical catheter matrix is nylon, polyurethane, polyethylene, polrvinyl chloride, Pebax etc.
In addition, hydrophilic coating solution spraying after can also will preparing by spraying equipment is on the medical catheter surface, thereby form uniform coating on the surface of medical catheter, the coating after spraying need be dried processing at normal temperatures, again medical catheter is carried out drying.
Embodiment five
The invention provides the compositions of the lubricated hydrophilic coating of a kind of medical catheter, said composition is made up of acetals polymer, hydrophilic polymer and citric acid ester plasticiser, and the weight proportion scope of said components is acetals polymer 40%, hydrophilic polymer 30%, citric acid ester plasticiser 30%; The molecular weight of hydrophilic polymer is 1500000.Wherein, the acetals polymer is a polyvinyl butyral resin; Hydrophilic polymer is one or more in Polyethylene Glycol, polyvinylpyrrolidone, the polyethylene glycol oxide; The citric acid ester plasticiser is a kind of in triethyl citrate, tributyl citrate, the tributyl 2-acetylcitrate.
Above-mentioned composition is mixed the back fully stir the hydrophilic coating solution for the treatment of to dissolve fully back formation homogeneous with organic solvent, the concentration range of hydrophilic coating solution is 6%.Wherein, organic solvent is N, one or more in dinethylformamide, oxolane, ethyl acetate, butyl acetate, butanone, dehydrated alcohol, isopropyl alcohol, acetone, chloroform, the toluene.This organic solution is by the butanone of 25ml, the dehydrated alcohol of 70ml, the butyl acetate of 20ml, the N of 20ml, and dinethylformamide is mixed and made into.
The hydrophilic coating solution that medical catheter is immersed in after the preparation took out after 2 minutes, dried at normal temperatures earlier then, again dried was carried out on the surface of medical catheter.Wherein, needed temperature is 80 ℃ during to the medical catheter drying, and the dry needed time is 60 minutes.
The material of medical catheter matrix is nylon, polyurethane, polyethylene, polrvinyl chloride, Pebax etc.
In addition, hydrophilic coating solution spraying after can also will preparing by spraying equipment is on the medical catheter surface, thereby form uniform coating on the surface of medical catheter, the coating after spraying need be dried processing at normal temperatures, again medical catheter is carried out drying.
Only the above person only is preferred embodiment of the present invention, is familiar with the professional person of this skill such as. after understanding technological means of the present invention, natural energy is changed under instruction of the present invention according to the needs of reality.Therefore all equal variation and modifications of being done according to the present patent application claim once should still belong in the scope that patent of the present invention contains.
Claims (10)
1. the compositions of the lubricated hydrophilic coating of a medical catheter, said composition is made up of acetals polymer, hydrophilic polymer and citric acid ester plasticiser, it is characterized in that the weight proportion scope of said components is acetals polymer 15～40%, hydrophilic polymer 30～70%, citric acid ester plasticiser 15～30%; The molecular weight of described hydrophilic polymer is 100000～1500000.
2. the compositions of the lubricated hydrophilic coating of a kind of medical catheter as claimed in claim 1 is characterized in that the weight proportion numerical value of said components is: acetals polymer 15%, hydrophilic polymer 30%, citric acid ester plasticiser 15%; The molecular weight of described hydrophilic polymer is 100000.
3. the compositions of the lubricated hydrophilic coating of a kind of medical catheter as claimed in claim 1, it is characterized in that the weight proportion scope of said components is: acetals polymer 20%～35%, hydrophilic polymer 40%～60%, citric acid ester plasticiser 20%～30%; The molecular weight of described hydrophilic polymer is 900000.
4. the compositions of the lubricated hydrophilic coating of a kind of medical catheter as claimed in claim 1 is characterized in that the weight proportion numerical value of said components is: acetals polymer 40%, hydrophilic polymer 70%, citric acid ester plasticiser 30%; The molecular weight of described hydrophilic polymer is 1500000.
5. as the compositions of the lubricated hydrophilic coating of any described a kind of medical catheter in the claim 1 to 4, it is characterized in that described acetals polymer is a polyvinyl butyral resin; Described hydrophilic polymer is one or more in Polyethylene Glycol, polyvinylpyrrolidone, the polyethylene glycol oxide; Described citric acid ester plasticiser is a kind of in triethyl citrate, tributyl citrate, the tributyl 2-acetylcitrate.
6. the preparation of compositions method of the lubricated hydrophilic coating of a kind of medical catheter as claimed in claim 1, it is characterized in that, described compositions is mixed the back fully stir the hydrophilic coating solution for the treatment of to dissolve fully back formation homogeneous with organic solvent, the concentration range of hydrophilic coating solution is 2～6%.
7. the preparation of compositions method of the lubricated hydrophilic coating of a kind of medical catheter as claimed in claim 6, it is characterized in that, described organic solvent is N, one or more in dinethylformamide, oxolane, ethyl acetate, butyl acetate, butanone, dehydrated alcohol, isopropyl alcohol, acetone, chloroform, the toluene.
8. the using method of the compositions of the lubricated hydrophilic coating of a kind of medical catheter as claimed in claim 6, it is characterized in that, the hydrophilic coating solution that medical catheter is immersed in after the preparation took out after 1～2 minute, dried processing then at normal temperatures, again medical catheter was carried out drying.
9. the using method of the compositions of the lubricated hydrophilic coating of a kind of medical catheter as claimed in claim 8 is characterized in that, needed temperature is 50～80 ℃ during to the medical catheter drying, and the dry needed time is 10～60 minutes.
10. the using method of the compositions of the lubricated hydrophilic coating of a kind of medical catheter as claimed in claim 6, it is characterized in that, hydrophilic coating solution spraying after will preparing by spraying equipment is on the medical catheter surface, thereby be formed with uniform coating on the surface of medical catheter, coating after spraying need be dried processing at normal temperatures, again medical catheter is carried out drying.
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| CN2011100053325A CN102166377A (en) | 2011-01-05 | 2011-01-05 | Composition, preparation method and use method of lubricating hydrophilic coating for medical catheter |
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| CN2011100053325A CN102166377A (en) | 2011-01-05 | 2011-01-05 | Composition, preparation method and use method of lubricating hydrophilic coating for medical catheter |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102973986A (en) * | 2012-07-19 | 2013-03-20 | 黄斌 | Medical super-lubricity antibacterial catheter coating liquid |
| CN103893832A (en) * | 2014-02-20 | 2014-07-02 | 威海洁瑞医用制品有限公司 | Polylactic acid venous indwelling needle guide pipe |
| CN104399168A (en) * | 2014-11-28 | 2015-03-11 | 中山市普利斯微创介入医械有限公司 | Anesthetic catheter with hydrophilic coating on front section |
| CN105530966A (en) * | 2013-07-15 | 2016-04-27 | 波士顿科学国际有限公司 | Lubricious coating compositions |
| CN110075364A (en) * | 2019-03-18 | 2019-08-02 | 科塞尔医疗科技（苏州）有限公司 | A kind of hydrophilic coating solution of interposing catheter and preparation method thereof and application method |
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| CN1742042A (en) * | 2002-12-20 | 2006-03-01 | 科洛普拉斯特公司 | A hydrophilic coating and a method for the preparation thereof |
| US20060204535A1 (en) * | 2005-02-25 | 2006-09-14 | Johnson Johnnie M | Cell-friendly cannula and needle |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102973986A (en) * | 2012-07-19 | 2013-03-20 | 黄斌 | Medical super-lubricity antibacterial catheter coating liquid |
| CN105530966A (en) * | 2013-07-15 | 2016-04-27 | 波士顿科学国际有限公司 | Lubricious coating compositions |
| CN103893832A (en) * | 2014-02-20 | 2014-07-02 | 威海洁瑞医用制品有限公司 | Polylactic acid venous indwelling needle guide pipe |
| CN103893832B (en) * | 2014-02-20 | 2015-10-14 | 威海洁瑞医用制品有限公司 | A kind of polylactic acid vein indwelling needle catheter |
| CN104399168A (en) * | 2014-11-28 | 2015-03-11 | 中山市普利斯微创介入医械有限公司 | Anesthetic catheter with hydrophilic coating on front section |
| CN110075364A (en) * | 2019-03-18 | 2019-08-02 | 科塞尔医疗科技（苏州）有限公司 | A kind of hydrophilic coating solution of interposing catheter and preparation method thereof and application method |
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Application publication date: 20110831 |