CN102150854B - Health food with auxiliary protection function to chemical liver injury - Google Patents
Health food with auxiliary protection function to chemical liver injury Download PDFInfo
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- CN102150854B CN102150854B CN2011100340688A CN201110034068A CN102150854B CN 102150854 B CN102150854 B CN 102150854B CN 2011100340688 A CN2011100340688 A CN 2011100340688A CN 201110034068 A CN201110034068 A CN 201110034068A CN 102150854 B CN102150854 B CN 102150854B
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Abstract
The invention discloses a health food with an auxiliary protection function to chemical liver injury, which comprises the following components in percent by weight: 1-95 percent of cysteine, 0-90 percent of glutamine, 0-60 percent of taurine, 0-60 percent of alanine, 0-30 percent of glycine, 0-30 percent of arginine, 0-20 percent of brown rice germ meal and 1-97 percent of auxiliary material. The health food is scientifically prepared by selecting raw materials with accurate effects, thereby effects are ensured, decomposition of toxic chemical materials is accelerated by reducing alanine transaminase and glutamic-oxalacetic transaminease, absorption of a human body to the toxic chemical materials is reduced and an auxiliary protection function is obtained for chemical liver injury.
Description
Technical field
The present invention relates to a kind of health food, more particularly, the present invention relates to a kind of health food that chemical damage is had auxiliary protection function.
Background technology
Liver is human body maximum, most important digestion body of gland, and it has powerful defence function of detoxification to the external many adverse factors with the metabolism generation of human body.In the daily life, the chemistry harmful substance can enter liver by intestines and stomach portal vein or body circulation and transform, and therefore, liver is subjected to the infringement of the harmful toxicant of chemistry easily, causes chemical damage.Chemical damage, be to be decreased by the liver that the chemistry Hepatoxic substance causes, it is mainly derived from the chemistry poisonous substance that contacts in excessive drinking, drug induced injury and the productive life, these harmful poisonous substances are general susceptible in the crowd, incubation period is short; the process of pathology is directly related with the dosage of infection, can cause liver necrosis of liver cells, fatty distortion, cirrhosis, liver fibrosis in various degree, even liver cancer.
Chemical damage focuses on prevention; avoid contacting poisonous chemical substance as far as possible; and by dietotherapy or the suitable health food that chemical damage is had auxiliary protection function that replenishes; to strengthen body physique; improve Abwehrkraft des Koepers; in time removing the harmful poisonous substance of chemistry, also is a liver-protective effective way.
Summary of the invention
The object of the present invention is to provide a kind of health food that chemical damage is had auxiliary protection function.
The objective of the invention is to be achieved through the following technical solutions:
A kind of have the health food of auxiliary protection function to chemical damage, counts by weight percentage to comprise following component:
Cysteine 1%～95%, glutamine 0%～90%,
Taurine 0%～60%, alanine 0%～60%,
Glycine 0%～30%, arginine 0%～30%,
Brown rice germ powder 0%～20%, auxiliary material 1%～97%.
Preferably, health food of the present invention, count by weight percentage and comprise following component:
Cysteine 3%～50%, glutamine 0%～30%,
Taurine 0%～30%, alanine 0%～30%,
Glycine 0%～10%, arginine 0%～10%,
Brown rice germ powder 0%～10%, auxiliary material 30%～97%.
Health food of the present invention can be made into peroral dosage forms such as pulvis, granule, tablet, hard capsule, soft capsule and oral liquid.
In the present invention, described auxiliary material is selected from one or more the combination in Fruit powder, flavoring essence, high sweetener, acid, filler, adhesive, lubricant, anticorrisive agent, suspending agent, food coloring, diluent and the plasticizer.
Wherein, described Fruit powder comprises orange powder, lemon powder, cherry powder, apple powder and strawberry powder etc.; Described flavoring essence comprises orange essence, lemon extract, cherry essence, flavoring apple essence and strawberry essence etc.; Described high sweetener comprises Sucralose, AK sugar, Aspartame, mogroside, knob is sweet and Stevioside etc.; Described acid comprises citric acid, malic acid, lactic acid, tartaric acid and fumaric acid etc.; Described filler comprises fructose, antierythrite, hydroxyl isomaltulose, maltitol, sweet mellow wine, sucrose, glucose, starch, dextrin and maltodextrin etc.; Described adhesive comprises Hydroxypropyl methylcellulose, pregelatinized starch and PVP etc.; Described lubricant comprises talcum powder, dolomol, silica and stearic acid etc.; Described anticorrisive agent comprises Sodium Benzoate, benzoic acid, sorbic acid, potassium sorbate and parabens etc.; Described suspending agent comprises sodium carboxymethylcellulose, sodium alginate and beeswax etc.; Described food coloring comprises burnt sugar coloring, Gardenia Yellow, curcumin and chlorophyll etc.; Described diluent comprises that purified water, edible vegetable oil, propane diols and molecular weight are 400～2000 polyethylene glycol etc.; Described plasticizer comprises glycerine and sorbierite etc.
The raw material of health food screening exact efficacy of the present invention carries out scientific composition; thereby guarantee the effect of product; by reducing glutamic-pyruvic transaminase, glutamic-oxalacetic transaminease; accelerate the decomposition of poisonous chemical substance; reduce body to the absorption of toxic chemical substance, chemical damage is had auxiliary protection function.
Amino acid is the fundamental structural unit of protein, participates in the synthetic of interior all protein of body.Research to the amino acid physiological action in recent years discloses, amino acid both can be used as nutritional factors plays nutritious supplementary pharmaceutical to human body effect, can stimulate the hypophysis cerebri growth hormone releasing to bring into play physiological action widely again, compound amino acid can replenish amino acid more comprehensively, and physiological action is than single amino acid better effects if.Glutamine cysteine in the prescription of the present invention, with glycine liver protection effect is arranged separately not only; and in vivo with the elemental selenium acting in conjunction; form glutathione; increase the endogenous antioxidant system of body; removed polyradical; reduce the damage of radical pair liver, play the effect of protection liver.
Cysteine is sulfur-containing amino acid, and sulfur-containing amino acid plays different physiological roles in animal body, comprises ingesting, growing and immunity etc.Result of study shows that cysteine has the effect of blocking-up hepatic injury, and treatment and prevention trinitrotoluene (TNT) poisoning are had certain effect.Have report to show, in amino acid is tested alcohol metabolism, irritate and compare with blank control group with the L-cysteine, L-cysteine group mouse can be removed oxidation fast and be removed acetaldehyde, and the acetaldehyde residual quantity in mouse blood, liver and the brain is less.
Glutamine is the abundantest free amino acid of people's in-vivo content, is important nitrogen carrier and donor, has enhancing immunity, improves motion and antioxidant ability of organism, improves different physiological roles such as brain function and detoxifcation.Result of study shows that glutamine all has protective effect to the hepatocellular injury that galactosamine/lipopolysaccharides, carbon tetrachloride, alcohol etc. cause.
Taurine is a kind of free amino acid that extensively is present in the organism.The synthesising part of taurine is liver, is the abundant sulfur-containing amino acid of a kind of content in the body, has enhancing immunity, delays senility, various biological functions such as hypotensive, hypoglycemic, strong liver cholagogic, detoxifcation, platelet aggregation-against, heat-clearing calmness.Result of study shows that taurine all has protective effect to the hepatocellular injury that carbon tetrachloride, adriamycin, aflatoxin B1, Paracetamol, endoxan and alcohol etc. cause.
Alanine is a seed amino acid of needed by human body, and additional alanine can satisfy the needs of body metabolism.Result of study shows that additional alanine can improve alanine concentration in the blood plasma, accelerates NAD and generates, thereby impel alcohol to enter tricarboxylic acid cycle, and acceleration of alcohol metabolism can alleviate alcohol effectively to the infringement of liver.
Glycine is the simplest amino acid of chemical constitution, also is a kind of nonessential amino acid in the human body, is a kind of inhibiting nerve mediator in central nervous system.Discovering in recent years, glycine have effects such as anti-inflammatory, immunological regulation and protection liver.Zoopery shows that glycine increases ethanol head in vivo and crosses removing by reducing the content of alcohol in the rat stomach, reduce the amount that ethanol arrives liver in vivo, thereby the effect of liver is protected in performance.
Arginine is not only the constituent of body protein as a kind of conditionity essential amino acid, and is the synthetic precursor of multiple bioactivator.Arginine participates in urea cycle, influences cardiovascular system, nervous system and immune system by nitric oxide (NO) approach.Result of study shows that arginine is by improving the oxidation resistance of body, and the antagonism lipid peroxidation improves hepatocellular energetic supersession, thereby performance is to the protective effect of liver.
Brown rice germ contains abundant GABA, and it has hypotensive, reducing blood lipid, adjusting arrhythmia cordis, regulates hormone secretion, strengthens effects such as renal function, activation liver function and prevention of obesity, and can bring into play multiple physiological hygiene function.
Health food of the present invention proves through toxicological test and function test, safety non-toxic, and chemical damage is had the health-care effect of assistant protection function.
Description of drawings
Fig. 1 is the oral liquid preparation technology flow chart of health food of the present invention;
Fig. 2 is the granule preparation technology flow chart of health food of the present invention;
Fig. 3 is the hard capsule preparation technology flow chart of health food of the present invention;
Fig. 4 is the tablet producing technology flow chart of health food of the present invention;
Fig. 5 is the pulvis preparation technology flow chart of health food of the present invention;
Fig. 6 is the soft capsule preparation process chart of health food of the present invention.
The specific embodiment
Embodiment one: the preparation of the oral liquid of health food of the present invention
Take by weighing each component according to following percentage by weight:
Cysteine 3.00%, taurine 1.50%,
Alanine 1.00%, glycine 1.00%,
Citric acid 0.30%, fumaric acid 0.20%,
AK sugar 0.03%, potassium sorbate 0.05%,
Flavoring apple essence 0.20%.
Above-mentioned each component is mixed, add the abundant stirring and dissolving of an amount of purified water, constant volume, go up bottle placer then and carry out can, after sterilization treatment, namely make the oral liquid of health food of the present invention.
Embodiment two: the preparation of the granule of health food of the present invention
Take by weighing each component according to following percentage by weight:
Cysteine 20.0%, glutamine 8.00%,
Taurine 5.00%, alanine 8.00%,
Arginine 5.00%, sucrose 15.0%,
Antierythrite 26.9%, maltodextrin 5.00%,
PVP 2.00%, orange powder 3.50%,
Orange essence 1.50%, Aspartame 0.10%.
Earlier to the processing of pulverizing and sieve of cysteine, glutamine, alanine, arginine, sucrose and antierythrite, get material and taurine, maltodextrin, PVP, orange powder and Aspartame after the pulverizing, in mixer, mix; In the material that mixes, add an amount of alcohol, in granulator, granulate; The particle that makes is carried out drying handle in drying box, dried particle places mixer to mix with orange essence, namely makes the granule of health food of the present invention.
Embodiment three: the preparation of the hard capsule of health food of the present invention
Take by weighing each component according to following percentage by weight:
Cysteine 40.0%, glutamine 8.00%,
Alanine 7.00%, brown rice germ powder 2.00%,
Dextrin 22.5%, pregelatinized starch 20.0%,
Dolomol 0.50%.
Earlier to the processing of sieving of cysteine, glutamine and alanine; Get material and brown rice germ powder, dextrin, pregelatinized starch and dolomol after sieving, in mixer, mix; Adopt Autocapsulefillingmachine to fill then, after polishing, namely make the hard capsule of health food of the present invention.
Embodiment four: the preparation of the tablet of health food of the present invention
Take by weighing each component according to following percentage by weight:
Cysteine 35.0%, alanine 16.0%,
Taurine 20.0%, brown rice germ powder 5.00%,
Sweet mellow wine 5.00%, PVP 3.00%,
Dextrin 5.00%, Hydroxypropyl methylcellulose 1.00%,
Pregelatinized starch 6.00%, citric acid 0.70%,
Malic acid 1.50%, mogroside 0.30%,
Sucralose 0.50%, dolomol 0.70%,
Silica 0.30%.
Earlier to the processing of pulverizing and sieve of cysteine, alanine, sweet mellow wine, brown rice germ powder, citric acid and malic acid; Get material and taurine, dextrin, PVP, pregelatinized starch, Hydroxypropyl methylcellulose, Sucralose and mogroside after the pulverizing, in mixer, mix; Adopt granulator to granulate, in drying box, carry out drying then and handle; Dried particle adopts pelletizing machine to carry out whole grain again, adds dolomol then and silica always mixes, and the particle that mixes adopts tablet press machine to carry out compressing tablet, namely makes the tablet of health food of the present invention.
Get the health food that present embodiment makes, carry out animal function test and the test of security toxicological evaluation according to the evaluation method of Ministry of Public Health's " health food check and assessment technique standard " (version in 2003).
The animal function test is the result show: this health food can obviously reduce serum glutamic pyruvic transminase, glutamic-oxalacetic transaminease content, alleviates pathological symptom, and the chemical damage of animal is had assistant protection function.
Security toxicological evaluation result of the test is as follows: 1, acute toxinology experiment: sample is 10300mg/kg to the LD50 (95% fiducial limit) of male and female small white mouse acute oral toxicity test; 2, dimension nuclear test result: feminine gender; 3, sperm malformation test result: feminine gender; 4, Salmonella reversion test result: feminine gender; 5,30 days feeding trials: the experimental animal growing state is good, hematological examination, and biochemical analysis, main dirty body is histological examination result when compare with control group, all no significant difference.Security toxicology test result shows this health food safety non-toxic.
Embodiment five: the preparation of the pulvis of health food of the present invention
Cysteine 15.0%, taurine 15.0%,
Alanine 10.0%, arginine 10.0%,
Fructose 25.0%, maltitol 14.8%,
Strawberry powder 4.00%, cherry powder 3.00%,
Citric acid 2.00%, strawberry essence 0.50%,
Lemon extract 0.50%, Stevioside 0.15%,
Sucralose 0.05%.
Place mixer to mix above-mentioned each component, carry out packing with racking machine then, namely make the pulvis of health food of the present invention.
Embodiment six: the preparation of soft capsule of health food of the present invention
Feed liquid: cysteine 5.00%, taurine 20.0%,
Glutamine 10.0%, glycine 5.00%,
Beeswax 3.00%, edible vegetable oil 57.0%.
Glue: gelatin 42.0%, glycerine 17.0%,
Purified water 40.0%, burnt sugar coloring 0.85%,
Ethyl-para-hydroxybenzoate 0.15%.
Earlier to the processing of pulverizing and sieve of cysteine, glutamine, taurine and glycine; Get material and edible vegetable oil and beeswax after the pulverizing, be mixed with suspended matter.Get gelatin, glycerine, purified water, burnt sugar coloring and ethyl-para-hydroxybenzoate, colloidal sol is made glue.The suspended matter that makes is made soft capsule with the pellet press pelleting, after typing, washing ball and dry the processing, namely make the soft capsule of health food of the present invention.
Claims (7)
1. one kind has the health food of auxiliary protection function to chemical damage, counts by weight percentage to comprise following component:
Cysteine 1%～95%, glutamine 0%～90%,
Taurine 0%～60%, alanine 0%～60%,
Glycine 0%～30%, arginine 0%～30%,
Brown rice germ powder 0%～20%, auxiliary material 1%～97%,
Wherein the weight content of glutamine, taurine, alanine, glycine, arginine and brown rice germ powder is not 0 simultaneously.
2. health food according to claim 1 is characterized in that, counts by weight percentage to comprise following component:
Cysteine 3%～50%, glutamine 0%～30%,
Taurine 0%～30%, alanine 0%～30%,
Glycine 0%～10%, arginine 0%～10%,
Brown rice germ powder 0%～10%, auxiliary material 30%～97%,
Wherein the weight content of glutamine, taurine, alanine, glycine, arginine and brown rice germ powder is not 0 simultaneously.
3. health food according to claim 1 and 2 is characterized in that: described auxiliary material is selected from one or more the combination in Fruit powder, flavoring essence, high sweetener, acid, filler, adhesive, lubricant, anticorrisive agent, suspending agent, food coloring, diluent and the plasticizer.
4. health food according to claim 3, it is characterized in that: described Fruit powder comprises orange powder, lemon powder, cherry powder, apple powder and strawberry powder; Described flavoring essence comprises orange essence, lemon extract, cherry essence, flavoring apple essence and strawberry essence; Described high sweetener comprises Sucralose, AK sugar, Aspartame, mogroside, knob is sweet and Stevioside; Described acid comprises citric acid, malic acid, lactic acid, tartaric acid and fumaric acid; Described food coloring comprises burnt sugar coloring, Gardenia Yellow, curcumin and chlorophyll.
5. health food according to claim 3, it is characterized in that: described filler comprises fructose, antierythrite, hydroxyl isomaltulose, maltitol, sweet mellow wine, sucrose, glucose, starch, dextrin and maltodextrin; Described adhesive comprises Hydroxypropyl methylcellulose, pregelatinized starch and PVP; Described lubricant comprises talcum powder, dolomol, silica and stearic acid; Described anticorrisive agent comprises Sodium Benzoate, benzoic acid, sorbic acid, potassium sorbate and parabens; Described suspending agent comprises sodium carboxymethylcellulose, sodium alginate and beeswax; Described diluent comprises that purified water, edible vegetable oil, propane diols and molecular weight are 400～2000 polyethylene glycol; Described plasticizer comprises glycerine and sorbierite.
6. health food according to claim 1 and 2, it is characterized in that: described health food is prepared to oral formulations.
7. health food according to claim 6, it is characterized in that: described oral formulations comprises pulvis, granule, tablet, hard capsule, soft capsule and oral liquid.
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| CN2011100340688A CN102150854B (en) | 2011-02-01 | 2011-02-01 | Health food with auxiliary protection function to chemical liver injury |
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| CN2011100340688A CN102150854B (en) | 2011-02-01 | 2011-02-01 | Health food with auxiliary protection function to chemical liver injury |
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| CN102150854B true CN102150854B (en) | 2013-08-28 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103519164A (en) * | 2013-09-12 | 2014-01-22 | 北京中科邦尼国际科技有限责任公司 | Amino acid and plant compound composition for relieving alcoholism and protecting liver and application thereof in foods and health foods |
| JPWO2017141986A1 (en) * | 2016-02-16 | 2018-12-06 | 味の素株式会社 | Composition having kokumi imparting function |
| CN106923346B (en) * | 2017-03-10 | 2021-07-13 | 深圳奥萨制药有限公司 | Selected composite vitamin health product and application thereof |
| CN113973961A (en) * | 2021-10-27 | 2022-01-28 | 上海圣岳生物科技有限公司 | Pressed candy for promoting ubiquitination metabolic pathway of human body and preparation method thereof |
| CN114470150B (en) * | 2021-12-13 | 2022-12-27 | 完美（广东）日用品有限公司 | Application of chicken-derived small molecular peptide in preparation of product for preventing and improving liver injury and secondary symptoms thereof and product |
| CN114601172B (en) * | 2022-03-10 | 2024-03-19 | 山东若尧特医食品有限公司 | Formula food with special medical application of glutamine composition and preparation method thereof |
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Effective date of registration: 20170707 Address after: 528402 Dongming Road, Guangdong city of Zhongshan province (Shiqi District Private Science and Technology Park) Co-patentee after: Perfect (Guangdong) Commodity Co., Ltd. Patentee after: Perfect (China) Co., Ltd. Address before: 528402 Dongming Road, Guangdong city of Zhongshan province (Shiqi District Private Science and Technology Park) Patentee before: Perfect (China) Co., Ltd. |
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Effective date of registration: 20210107 Address after: 528402 private science and Technology Park, Dongming North Road, Shiqi District, Zhongshan, Guangdong Patentee after: PERFECT (CHINA) Co.,Ltd. Patentee after: PERFECT (GUANGDONG) COMMODITY Co.,Ltd. Patentee after: Guangdong perfect life health Technology Research Institute Co.,Ltd. Address before: 528402 Dongming North Road, Shiqi District, Guangdong City, Zhongshan province (Private Science Park) Patentee before: PERFECT (CHINA) Co.,Ltd. Patentee before: PERFECT (GUANGDONG) COMMODITY Co.,Ltd. |