CN102125630A - Traditional Chinese medicinal preparation for treating chronic hepatitis B and preparation method thereof - Google Patents

Abstract

The invention relates to a traditional Chinese medicinal preparation for treating chronic hepatitis B and a preparation method thereof. The traditional Chinese medicinal preparation comprises the following raw materials: Chinese thorowax root, largehead atractylodes rhizome, white peony alba, safflower, the root of red-rooted salvia, spreading hedyotis herb, Rehmannia root, barbary wolfberry fruit and common monkshood root. The preparation method is as follows: in addition to the raw materials, adjuvant materials or solutions meeting the pharmaceutical standards are added to make pharmaceutically acceptable solid preparation products or liquid preparation products. The traditional Chinese medicinal preparation has the effects of invigorating qi, activating blood circulation, relieving depression of the liver-qi and removing heat and damp evils, achieves the purposes of combination of reinforcement and elimination and simultaneous treatment of symptoms and root causes, and serves the functions of replenishing vital essence and nourishing the blood, promoting blood flow to relieve pain and improving visceral dysfunction. The traditional Chinese medicinal preparation has a good curative effect on chronic viral hepatitis.

Description

Chinese medicine preparation of treatment chronic hepatitis B and preparation method thereof

Technical field

The present invention relates to a kind of Chinese medicine preparation for the treatment of hepatitis, particularly treat Chinese medicine preparation of chronic hepatitis and preparation method thereof.

Technical field

Hepatitis is one of more serious disease of digestive system, and its clinical symptoms shows as inappetence, detests oil, feels sick, abdominal distention, loose stool etc.Most patients have weak, uncomfortable liver area.Normal sx when fatigue, mood change, climate change.Part patient has the performance of low grade fever and nervous dysfunction, as giddy, insomnia, dreaminess or drowsiness, absent minded, hypomnesis, being irritable and getting angry easily, discomfort, lassitude loin and legs etc. all over the body.Part patient can have bleeding tendency, shows as gingiva bleeding gingival hemorrhage, epistaxis, subcutaneous hemorrhage point or ecchymosis.A few patients does not have any subjective symptoms.In, severe chronic hepatitis patient health status descends, and can be the liver sexually transmitted disease (STD) and hold, and shows as dim complexion, and is steel gray simple and unadorned.

Pathological change according to its symptom and sign of the traditional Chinese medical science and liver is divided into chronic persistent hepatitis and chronic active hepatitis.

1. chronic persistent hepatitis: patient's symptom and sign and liver function change all not serious, and common sympton is weak, inappetence, and jaundice appears in hepatic region mild pain once in a while, the liver silght enlargement, quality can be medium hard, slight tenderness.A few patients can have splenomegaly.ALT raises or raises repeatedly, and other liver function tests and Proteometabolism are roughly normal.The cellular infiltration that its main pathological change characteristics are the portal area soaks into cell based on lymphocyte, histiocyte, and neutrophilic granulocyte seldom.Visible a small amount of hepatocellular degeneration or spotty necrosis in the liver parenchyma.But lobules of liver is complete, does not have the liver cell regeneration tuberosity to form, thereby does not develop or hepatitis interstitialis chronica, general prognosis bona.

2. chronic active hepatitis B: clinical symptoms is heavier, and the course of disease is through aggravating to be its feature repeatedly with the state of an illness.Some expert introductions are said, symptoms such as weak, the anorexia of chronic active hepatitis, abdominal distention, pain in the hepatic region are obvious, medium degree jaundice, hepatomegaly, spleen often can touch, hepatic facies has spider angioma and liver palm and the performance of liver external system is arranged, and arthritis, vasculitis, erythra, ALT continue or raise repeatedly, Proteometabolism is unusual, in vain/and the ball inversion, leukocyte and thrombocytopenia, and anemia can be arranged.Its pathological characters is that the chronic inflammatory cell of portal area soaks into and the interior intrusion of liver parenchyma towards periphery develops, and destroys the lobules of liver limiting plate, and the downright bad and lobule interior interval formation of hepatocellular degeneration engenders the liver cell regeneration tuberosity subsequently, and pathological changes transforms to hepatitis interstitialis chronica gradually.It is generally acknowledged that chronic active hepatitis causes hepatitis interstitialis chronica easily.

Chronic type B viral hepatitis still lacks specific Therapeutic Method at present.A lot of medical experts are still carrying out various test of cure at present.Someone thinks, the etiopathogenesis of primary disease may with the virulence of Strain, factors such as the quantity of infected cell and the immune effect of patient have certain relation, and the Western medicine of its treatment divides three classes substantially: 1. antiviral drugs: comprise human leukocyte interferon, human fibroblast interferon, people's immune interferon, cytosine arabinoside, phosphoric acid arabinose born of the same parents, acycloguanosine, virazole, phosphorus carboxyl formic acid, polyinosini glycosides.Wherein comparatively sure with efficacy of interferon therapy.2. immunomodulator: anti-hepatis B immunoglobulin, levamisole, Hepatitis B virus vaccine, transfer factor, immune ribonucleic acid, bacillus calmette-guerin vaccine, immunosuppressant, thymosin, polyporusum bellatus etc., wherein comparatively effective with immune ribonucleic acid.3. improve the hepatocyte function medicine: as inosine, compound vitamin B, vitamin C, vitamin K, hepatocyte growth-promoting factors etc.

Some medical facility and medical personnel have delivered the more open source literature report that utilizes Chinese herbal treatment chronic type b hepatopathy in recent years, for example:

1, Infectious Disease of [autograph] compound monoammonium glycyrrhizinate coupling Oxymatrine in Treating Chronic Hepatitis B clinical observation on the therapeutic effect [author] He Guixiang [mechanism] People's Hospital of Zhuji City, [periodical name] CHINA JOURNAL OF CHINESE MATERIA MEDICA .2008,33 (4) .-443-444[digests] at present chronic hepatitis B is also lacked specific treatment, the general comprehensive treatment measure of adopting comprises antiviral, immunomodulating, improves liver function and anti-hepatic fibrosis etc. more.Kurarinone has the effect that suppresses hepatitis B replication and anti-hepatic fibrosis, and being used for treating chronic hepatitis B clinically has curative effect preferably; Compound monoammonium glycyrrhizinate treatment chronic viral hepatitis has preferably and protects the liver, falls enzyme and hemobilirubin decline effect synchronously.

2, [autograph] mattress bavin four monarch's soup treatment chronic viral hepatitis 197 examples [author] Chen Yuanhua [1] Liu Guilan [2] Chen Benlie [3] [mechanism] [1] Shaanxi Province Affiliated Hospital of safe and comfortable Vocationl Technical College, [2] Shaanxi Province's Ankang City Hanbin District junior middle school's infirmary, [3] Shaanxi Province's Ankang City Hanbin District west of a river town Miao Ling village second clinic, [digest] purpose: observe clearing away heat-damp and promoting diuresis, the curative effect of benefiting QI for activating blood circulation class drug matching treatment chronic viral hepatitis.Method: adopt mattress bavin four monarch's soup (Herba Artemisiae Scopariae, Herba Patriniae, Radix Isatidis, RADIX SALVIAE MILTIORRHIZAE, Fructus Gardeniae, Radix Bupleuri, Radix Pseudostellariae, the Rhizoma Atractylodis Macrocephalae, Massa Medicata Fermentata, Fructus Hordei Germinatus, Fructus Crataegi etc.) treatment primary disease 197 examples, result: total effective rate 89%, prompting: this method has eliminating damp-heat to primary disease, benefiting QI for activating blood circulation improves the effect of immunity.

3, advantage [author] Chen De of [autograph] kurarinone (fertile gloomy dried Thailand) soft capsule treatment chronic viral hepatitis forever Hao Yan as the 302 hospital of [mechanism] PLA, [periodical name] infectious disease information .2005 (z1) .-57[digest] 1 oxymatrine, oxymatrine (Oxymatrine, OM) be a kind of alkaloid aqueous solution preparation that from the Chinese medicine Herba Sophorae alopecuroidis, extracts, wherein oxymatrine accounts for more than 98%, molecular formula is C15H24N2O2H2O, molecular weight is 282, other are the sophocarpine of minute quantity, sophoramine, Chinese scholartree pyridine alkali etc. over nearly 2 years, our experiment finds that OM has direct resistance of hepatitis B (hepatitis B) virus function; Can suppress the collagen mobility, the control hepatic fibrosis; Can block the inductive hepatocyte aberrant apoptosis of various factors; Experimental, fulminant hepatic failure all had protective effect; Adopt Matrine Injection (containing OM) treatment chronic hepatitis B (chb) to obtain obvious curative effects clinically, hepatitis gravis and chronic hepatitis B severe patient are also had excellent curative greater than 98%.

4, [autograph] benefiting QI for activating blood circulation treatment by Chinese herbs chronic viral hepatitis 84 flat Dong Shengshan of routine clinical summary [author] Xu Rui [mechanism] not quite clear [periodical name] Journal of Traditional Chinese Medicine .2000,41 (1) .-36-37[digests] employing benefiting QI for activating blood circulation treatment by Chinese herbs chronic viral hepatitis 84 examples, substantially square: Radix Astragali 30g, Poria 30g, Radix Salviae Miltiorrhizae 30g, Radix Paeoniae Rubra 30g gives birth to mountain 30g Radix Et Rhizoma Rhei 15g, and day 1 dose is decocted in water for oral dose.On average took medicine 42.5 days.Clinical symptoms is improved in 3 weeks substantially as a result.HBe Ag and HBV-DNA negative conversion rate are respectively 45.9%, 63.22%.ALT normalization rate 82.3%, average multiple often between 2.88 weeks.Back TBIL descends, PTT shortens, albumin improves and treatment before compare difference utmost point significance arranged.Though A/G increases before treating.

5, Chinese patent, CN200810105034.1, a kind of Chinese medicine composition for the treatment of chronic viral hepatitis and preparation method thereof, Beijing Zhongtai Tianhe Science And Technology Co., Ltd., on April 25th, 2008 a kind of Chinese medicine composition for the treatment of chronic viral hepatitis.This Chinese medicine composition is made by the Radix Astragali, Radix Salviae Miltiorrhizae, Rhizoma Polygoni Cuspidati, Radix Arnebiae (Radix Lithospermi), Herba Agrimoniae, the Radix Pulsatillae, Herba Hedyotidis Diffusae, Herba Lobeliae Chinensis, Endothelium Corneum Gigeriae Galli, Rhizoma Curcumae, Radix Notoginseng, Radix Curcumae, Herba Damnacanthi and/or pharmaceutically acceptable carrier.

6, Chinese patent, CN00129023.1, a kind of Chinese medicine composition that is used for the treatment of hepavirus disease, its preparation with and preparation method thereof, Hongkong Research Centre of Traditional Chinese Medicine Preparation for Hepatit, Huang Guoxiong, a kind of Chinese medicine composition that is used for the treatment of hepavirus disease, Chinese medicine composition, the pharmaceutically acceptable various dosage forms, particularly decoction of these Chinese medicine compositions and the preparation method of these Chinese medicine compositions and dosage form thereof especially for treatment chronic viral hepatitis and the liver external system disease that causes by virus.The Chinese medicine composition of this invention is characterised in that it comprises the following weight proportion raw material: Herba Artemisiae Scopariae 12-18 part, Radix Bupleuri 9-15 part, Fructus Forsythiae 9-15 part, Fructus Gardeniae 10-15 part, Radix Salviae Miltiorrhizae 9-15 part, Semen Persicae 9-15 part, Radix Astragali 12-18 part, Radix Curcumae 10-15 part, Radix Scutellariae 10-15 part, the Radix Rehmanniae/Radix Rehmanniae Preparata 12-18 part, the Radix Paeoniae Alba/Radix Paeoniae Rubra 10-15 part, Fructus Aurantii Immaturus 10-15 part, Pericarpium Citri Reticulatae Viride 10-15 part, Radix Puerariae 12-18 part.

7, Chinese patent, CN200410040713.7, a kind of treatment viral hepatitis Chinese medicinal formulae, Lee's generation harmony Lee generation harmony, treat acute and chronic viral hepatitis Chinese medicinal formulae, its prescription mainly by: Herba Abri, Rhizoma Paridis, Rhizoma Polygoni Cuspidati, Rhizoma Smilacis Glabrae, Rhizoma Picrorhizae, Radix Salviae Miltiorrhizae, Radix Notoginseng, Hirudo, Radix Astragali Mongolici (processed) etc. are formed.This prescription can clearing away heat-damp and promoting diuresis, dispel mental disorder congestion controls its mark, again can the kidney invigorating of soothing the liver reason spleen, the QI invigorating replenishing essence consolidates Zhi Qiben, and eliminating evil and just do not hinder, set upright and do not stay heresy, reach vital QI recovered after pathogens eliminated, negative and positive are flat secret, internal organs and accent, QI and blood smoothness.Adapt to viral hepatitis, early stage, mid-term, treatment of late stage, clinical total effective rate 96.57%, and can effectively prevent hepatic ascites or canceration.

8, Chinese patent, CN200410099268.1, a kind of Chinese medicine composition that is used for the treatment of hepatic disease and preparation method thereof, Second Military Medical University, PLA's Zhang Weidong; The Fu Peng; Li Huiliang; Zhang Chuan; Su Juan; Liu Run, a kind of Chinese medicine composition that is used for the treatment of hepatic disease and preparation method thereof.This Chinese medicine composition is the effective site that extraction, purification make from the Chinese medicine Herba Hyperici Japonici, and wherein the content of flavones ingredient is 80～99.5%.This flavones ingredient is mainly Quercitroside, isoquercitrin, the two xanthone C of Herba Hyperici Japonici and the two xanthone D of Herba Hyperici Japonici.The preparation method of above-mentioned composition is to be raw material with the Herba Hyperici Japonici medical material, through ethanol extraction, concentrate, regulate pH value, ethyl acetate extraction obtains total flavone valid target, has the advantage that technology is simple, the total flavones rate of transform is high.Chinese medicine composition of the present invention can be used for liver disease as the treatment of acute and chronic viral hepatitis, hepatic fibrosis, hepatic injury.

9, Chinese patent, title: GANJIAXIN PIAN application number: CN200710201688.X publication number: CN101385778, applicant: Fangda Pharmaceutical Co Ltd, Tonghua City, address: No. 50, Tonghua, Jilin Province city Dongchang District Jiang Xuelu, inventor: bring up right, summary: a kind of Chinese medicine preparation, promptly treat the medicine GANJIAXIN PIAN of hepatopathy.It is by Fructus Schisandrae Chinensis 317.5g, Radix Bupleuri 300g, and Herba Artemisiae Scopariae 300g, Radix Isatidis 300g, Polystictus Glycopeptide 20g, Pulvis Fellis Suis 20g, starch 100g, magnesium stearate 3.5g makes 1000.Be used for the treatment of chronic viral hepatitis, diseases such as chronic persistent hepatitis and liver cirrhosis.

10, Chinese patent, Chinese medicine composition of CN200710145284.3 treatment chronic viral hepatitis and preparation method thereof, Gao Xiang; No. 99, Beijing Road, Limin Economic and Technological Development Zone, Harbin City, Heilongjiang Province, Chinese medicine composition of a kind of new treatment chronic viral hepatitis and preparation method thereof, it is the compound Chinese medicinal preparation of being made by the Radix Astragali, Pulvis Fellis Suis, Pulvis Cornus Bubali Concentratus, Radix Bupleuri, Herba Hedyotidis Diffusae, Fructus Aurantii, Fructus Schisandrae Chinensis, Fructus Ligustri Lucidi, brave account, Endothelium Corneum Gigeriae Galli, Radix Salviae Miltiorrhizae and Radix Curcumae.More than in the 12 flavor medical materials, Pulvis Fellis Suis, Pulvis Cornus Bubali Concentratus are standby; All the other ten flavors are pulverized, are concentrated behind water extraction, drying is ground into fine powder again, again with Pulvis Fellis Suis, Pulvis Cornus Bubali Concentratus mixing, further can make the common dosage forms of Chinese medicine composition.

11, Chinese patent, CN200710061237.0 Chinese medicine preparation that is used for the treatment of acute, chronic hepatitis, Tianjin Feiying Pharmacy Co., Ltd.; Li Zongmao, a kind of Chinese medicine preparation that is used for the treatment of acute, chronic hepatitis, the blue the liver benefiting granule of mattress (or tablet, capsule).The composition of the Chinese medicine preparation that provides comprises: Herba Artemisiae Scopariae 150-250 part, Radix Isatidis 100-200 part, Fructus Forsythiae 100-200 part, Radix Curcumae 100-200 part, Radix Angelicae Sinensis 100-200 part, Rhizoma Gymnadeniae 100-200 part, Radix Salviae Miltiorrhizae 100-200 part, Herba Lophatheri 25-100 part.Through evidence, this invented technology is feasible, and the quality of the pharmaceutical preparations is controlled, and stability is good, has overcome shortcomings such as traditional Chinese medicine " big compound recipe ", " rough work "; Proving its determined curative effect through pharmacology and toxicological study, safely, have no side effect, clinical preferably basis is arranged again, is the ideal oral drugs of the acute and chronic viral hepatitis of treatment.The expert uses the blue the liver benefiting granule of mattress for many years and treats surplus the acute and chronic hepatitis ten thousand example and case is summarized, and the result shows that the blue the liver benefiting granule of mattress is improving clinical symptoms, protects the liver, falls enzyme, jaundice eliminating aspect obvious effective rate reaches 76.8%, total effective rate 87.2%.

12, Chinese patent, CN200810105034.1 treats Chinese medicine composition of chronic viral hepatitis and preparation method thereof for one kind, the He Junbao of Beijing Zhongtai Tianhe Science And Technology Co., Ltd., a kind of Chinese medicine composition for the treatment of chronic viral hepatitis.This Chinese medicine composition is made by the Radix Astragali, Radix Salviae Miltiorrhizae, Rhizoma Polygoni Cuspidati, Radix Arnebiae (Radix Lithospermi), Herba Agrimoniae, the Radix Pulsatillae, Herba Hedyotidis Diffusae, Herba Lobeliae Chinensis, Endothelium Corneum Gigeriae Galli, Rhizoma Curcumae, Radix Notoginseng, Radix Curcumae, Herba Damnacanthi and/or pharmaceutically acceptable carrier.This invention Chinese medicine composition has effects such as clearing away heat-damp and promoting diuresis, the liver soothing and the spleen invigorating, nourishing the liver and kidney, is used for diseases such as loss of appetite that chronic viral hepatitis causes, nauseating, weak, the glutted discomfort of epigastrium, hepatalgia.

13, the liniment of CN200810053177.2 treatment hepatopathy, Tianjin City Infectious Hospital is tranquil surplus strong; Pan Zanhong; Old Wei; Wu Xiliang; Wei Ronghuan, publication number: CN101269191, No. 75, Su Causeway road, Nankai District, Tianjin City, a kind of liniment for the treatment of hepatopathy, belonging to the specific physical character is the medicine configuration product of feature.It is that raw materials in portion by weight is made: take by weighing prepared slices of Chinese crude drugs Fructus Aurantii Immaturus, rhizoma sparganic, Radix Kansui, Semen Arecae, Ramulus Cinnamomi, Fructus Mori, Radix Et Rhizoma Rhei, Radix Scutellariae, Cortex Magnoliae Officinalis, Semen Pharbitidis, Herba Artemisiae Scopariae, Rhizoma Corydalis, Semen Persicae, Pericarpium Citri Reticulatae Viride, Radix Salviae Miltiorrhizae; Clean the back mix homogeneously, 60-70 ℃ dry 6-8 hour, mechanical activation comminution becomes medicated powder, crosses 80 mesh sieves, medicated powder and medical ventolin were in 1: 1: 5 ratio, thermosoling mixes the furnishing pasty state, cools off standby.This invention, Chinese traditional medicine point plaster, easy to use, drug transdermal absorbs, and drug effect is fast, avoids oral drugs in gastrointestinal dilution and toxic and side effects; Avoid the first pass effect of liver, be adapted to various acute and chronic hepatitis, patients such as alcoholic hepatitis, fatty liver, particularly long-term prescription and deficient qi and blood, the chronic hepatopathy patient of visceral dysfunction.

The Chinese medicine of above-mentioned open source literature report can be treated from the angle of the traditional Chinese medical science, certain effect is arranged aspect the enzyme protecting the liver, fall.But the prescription that has is complicated, have only in experimental stage, await clinical verification.

Summary of the invention

The purpose of this invention is to provide and a kind ofly have antiviral, immunomodulating, improve effects such as liver function and anti-hepatic fibrosis, being used for treating viral chronic hepatitis B clinically has the Chinese medicine preparation of curative effect preferably,

For reaching this purpose, the inventor studies Traditional Chinese medical theory, on the basis of secret prescription handed down in the family from generation to generation, replenished and put in order, excavate and develop a kind of have benefiting QI for activating blood circulation, dispersing the stagnated live-QI to relieve the stagnation of QI, clearing heat and expelling damp, nourishing YIN and supplementing blood, the imbalance of adjusting viscera function, viral chronic hepatitis B is had Chinese medicine preparation of better curative effect and preparation method thereof.

The effective ingredient that the present invention treats the Chinese medicine preparation of chronic hepatitis B mainly comprises following parts by weight of traditional Chinese medicines raw material:

Radix Bupleuri 8-15; Rhizoma Atractylodis Macrocephalae 8-15; Radix Paeoniae Alba 5-12; Flos Carthami 2-8; Radix Salviae Miltiorrhizae 5-12; Herba Hedyotidis Diffusae 15-25; Radix Rehmanniae 5-12; Fructus Lycii 5-12; Radix Aconiti Lateralis Preparata 2-8; Radix Glycyrrhizae Preparata 2-8.

According to Chinese medicine document record, more than the side of said each composition of Chinese medicine separate and be:

Radix Bupleuri, latin name: Bupleurum chinense is the dry root of umbelliferae bupleurum or Radix Bupeuri Scorzonerfolii..Its composition mainly contains saikoside, sterol, volatile oil and polysaccharide etc.The Radix Bupleuri bitter in the mouth, cold nature.The nature and flavor of Radix Bupleuri: hardship puts down, return through, go into liver, gallbladder meridian.Function: deliver, bring down a fever, soothing the liver, resolving depression, yang invigorating.Cure mainly: cat fever, alternate attack of chill and fever, malaria, side of body distending pain, menoxenia.Cure mainly to evacuate and bring down a fever the yang invigorating soothing liver-QI.Be used for cold, fever, alternate attack of chill and fever, malaria, stagnation of QI due to depression of the liver, sternal rib pain, the uterus comes off, menoxenia, proctoptosis etc.

Radix Bupleuri is as clearind deficient heat Chinese medicine, and the beginning is stated from Shennong's Herbal, classifies as top grade.

Modern pharmacological research proves: Radix Bupleuri has: 1, analgesic, antipyretic effect is steadily reliable; 2, calm, analgesia has the distending pain uncomfortable in chest of releasing, the dissipating depression of QI regulating menoxenia; 3, antibiotic, tubercule bacillus there is inhibitory action; 4, anti-liver injury effect; Injection of Radix Bupleuri (concentration 1: a 1) 1ml/ subcutaneous injection can significantly reduce the rat blood serum GPT rising that carbon tetrachloride causes in continuous 5 days, and hepatocellular degeneration and necrosis also obviously alleviate, and glycogen and rna content are also near normal in the hepatocyte.5, antiviral has had strong inhibitory effects to influenza virus, and is inhibited to the cytopathy that the 1st type poliomyelitis virus causes.

Document record, Radix Bupleuri also have following effect: 1, resisting pathogenic microbes, and Radix Bupleuri is external to have certain inhibitory action to staphylococcus aureus, Hemolytic streptococcus, vibrio cholera, tubercule bacillus, leptospira; Influenza virus, hepatitis virus, vaccinia virus had stronger inhibitory action.Injection of Radix Bupleuri is effective to herpes simplex keratitis, and the popularity hemorrhagic fever virus has certain effect.The Radix Bupleuri water extract can significantly reduce the lung exponential sum mortality rate of experimental viral pneumonia mice.2. antiinflammatory, the thick saponin of Radix Bupleuri, saikoside, Radix Bupleuri volatile oil all have antiinflammatory action.Saikoside all has inhibitory action to normal or adrenalectomy rat by the inflammatory reaction that multiple proinflammatory agent causes, and oral or drug administration by injection is all effective.Its antiinflammatory action relates to a plurality of links: reduce capillary permeability; Suppress leukoplania; Suppress granulation tissue hyperplasia.Radix Bupleuri anti-inflammatory mechanisms more complicated, the excited HPA endocrine axis of saikoside energy promotes hypophysis secretion ACTH, strengthens the antiinflammatory action of glucocorticoid.In addition, the effect that may also have direct inhibition inflammation-causing substance to discharge.3. promotion immunologic function, Radix Bupleuri polysaccharide, Radix Bupleuri hot water extract (high molecular component) can increase withered not (Kupffer) cytophagy, strengthen the function of natural killer cell, improve the virus-specific antibodies titre, improve lymhocyte transformation rate and skin delayed hypersensitivity.4. calmness, analgesia, antitussive, Radix Bupleuri decoct, total saponins, Saikogenin have obvious inhibitory action to the central nervous system, the spontaneous activity of animal is reduced, trained reflex suppresses, prolong the length of one's sleep of barbiturate, the effect of antagonism central stimulant (amfetamine, caffeine etc.).5. protect the liver, function of gallbladder promoting, blood fat reducing, Radix Bupleuri, a saikoside, bupleurumol, hitodesterol have hepatoprotective effect, the zoopery liver damage that multiple reason is caused has certain preventive and therapeutic effect.ALT, AST are reduced, alleviate hepatocyte injury, promote that liver function recovery is normal.The Radix Bupleuri mechanism of protecting the liver may be: saikoside has direct protective action to biomembrane (as mitochondrial membrane); Saikoside promotes pituitary secretion ACTH, and then the rising blood plasma cortisol; The exogenous steroid hormone of antagonism improves the resistivity of body to nonspecific stimulation to adrenal atrophy effect; Promote hepatocyte DNA synthetic, suppress the synthetic of extracellular matrix.Radix Bupleuri water logging agent and decoct have tangible choleretic effect, can make the bile output increase of laboratory animal, reduce cholic acid, bile pigments and content of cholesterol in the bile.The choleretic effect of Radix Bupleuri (processed with vinegar) is the strongest.The main component that Radix Bupleuri influences lipid metabolism is saikoside, sapogenin a and b, bupleurumol.Hitodesterol.Saikoside can make cholesterol, triglyceride and the phospholipid level of experimental hyperlipidemia animal reduce, and wherein the effect of triglyceride reducing is the most obvious; Also can quicken 14C-cholesterol and metabolite thereof from defecate.Bupleurumol, hitodesterol can reduce the cholesterol levels of hypercholesterolemia animal.Radix Bupleuri does not have obvious influence to intact animal's blood lipid level.

In sum, analgesic, the resisting pathogenic microbes of Radix Bupleuri, antiinflammatory promote that effect such as immunologic function is the pharmacodynamics basis of its reconciling superficies and interior effect; Protect the liver, function of gallbladder promoting, blood fat reducing, calmness, analgesia etc. be the embodiment of its dispersing the stagnated live-QI to relieve the stagnation of QI effect; And its effect to visceral smooth muscle may be relevant with its elevate a turnable ladder yang-energy effect.So the present invention classifies Radix Bupleuri as monarch drug.

The Rhizoma Atractylodis Macrocephalae, latin name: Rhizoma Atractylodis Macrocephalae, function cures mainly: invigorating the spleen and benefiting QI, the dampness diuretic, hidroschesis, antiabortive.Be used for insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.It is reported that mouse stomach Rhizoma Atractylodis Macrocephalae decocting liquid can be prevented and treated the hepatic injury due to the carbon tetrachloride, alleviate hepatic glycogen and reduce and the hepatocellular degeneration necrosis, promote hepatocyte to increase, the ALT of rising is descended.

Flos Carthami, Flos Carthami are the tubular flower of feverfew Flos Carthami Carthamus tinctorius L..Formal name used at school Carthamustinctorius L., function cures mainly: the latus rectum of invigorating blood circulation, eliminating stasis to stop pain.Be used for that amenorrhea, dysmenorrhea, lochia are not all right, lump in the abdomen mass in the abdomen, traumatic injury.

The traditional Chinese medical science thinks that Flos Carthami has effects such as promoting blood circulation to restore menstrual flow, reducing swelling and alleviating pain, beauty treatment and eliminating spot, is applicable to cold in blood amenorrhea, dysmenorrhea and various blood stasis pain, comprises chest pain etc. due to menolipsis, menorrhagia, the coronary heart disease.

Chemical constituent: contain carthamone, neocarthamin, saffloside, Carthamus yellow and flavochrome.Other contains safflower oil, comprises Palmic acid, myristic acid, lauric acid, stearic acid, arachidic acid, oleic acid etc. in the oil.

Pharmacological action: the effect of slight excited heart, reduction coronary resistance, increase coronary flow and myocardial nutrition blood flow is arranged; The protection and improve myocardial ischemia, dwindle myocardial infarct size; Reddish yellow pigment separator can be to arrhythmia; Decoct, water extract, Carthamus yellow etc. can be expanded peripheral vessels, bring high blood pressure down.The energy anticoagulant, the fortifying fibre protein dissolution reduces whole blood viscosity.Injection, ethanol extract, saffloside can significantly improve hypoxia-bearing capability, and the weary oxygen encephalopathy (HIE) of ischemia is had protective effect.Decoct has excitation to uterus and intestinal smooth muscle.Carthamus yellow has analgesia, calmness and anticonvulsant action to the central nervous system.In addition, Flos Carthami ethanol extract and water extract have antiinflammatory action; Carthamus yellow has immunosuppressive action.

Radix Salviae Miltiorrhizae, Radix Salviae Miltiorrhizae are the dry root of labiate Radix Salviae Miltiorrhizae, Latin plant animal mineral name: Slauia miltiorrhizaBunge, [meridian distribution of property and flavor] hardship is slightly cold.GUIXIN, Liver Channel.Its bitter in the mouth.[effect] promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, the relieving restlessness that clears away heart-fire, nourishing blood to tranquillize the mind.[curing mainly] menoxenia, the amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.[application] Radix Salviae Miltiorrhizae is used for the costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen caking, skin infection swells and ache, the tumbling down pain of injury, menoxenia, the amenorrhea dysmenorrhea, puerperal stasis of blood pain etc.Treatment costa sternales pain, lump in the abdomen caking, and menoxenia, amenorrhea dysmenorrhoea have good effect.

Have the silt of dispelling pain relieving, promoting blood circulation to restore menstrual flow, the effect of the relieving restlessness that clears away heart-fire is the activating blood herbs of using always.According to modern medicine checking, Radix Salviae Miltiorrhizae can coronary artery dilator, increase coronary flow, improve core ischemia, infarction and cardiac function, adjusts the rhythm of the heart, and can expand peripheral blood vessel, microcirculation improvement; Anticoagulant is arranged, promote fibrinolytic, anticoagulant suppresses thrombotic effect; The energy blood fat reducing suppresses the formation of the big branch of rabbit experiment arteria coronaria atheromatous plaque; Can suppress or alleviate hepatocellular degeneration, necrosis and inflammatory reaction, promote liver cell regeneration, and anti-fibrosis effect is arranged; Can improve the hypoxia-bearing capability of body; Can promote the reparation of tissue, quicken the healing of fracture, can shorten erythrocyte and hemoglobin convalescent period, make ceticulocytosis; Various bacteria and tubercule bacillus there is inhibition; The effect that suppresses nervus centralis is arranged.Also have enhance immunity, blood sugar lowering and antitumor action in addition.

Document is introduced, and the effect and the effect of Radix Salviae Miltiorrhizae are:

One, the effect of cardiovascular system

1. heart tonifying is strengthened myocardial contraction, is improved cardiac function, does not increase myocardial oxygen consumption; 2. to the blood vessel function coronary artery dilating, increase myocardial flow; The expansion peripheral blood vessel, blood flow increases; Cerebral blood flow descends; 3. antithrombotic forms and improves plasmin activity; Prolong, clotting time; Anticoagulant (it is synthetic to improve the interior cAMP level inhibition of platelet TXA2); Improve hemorheological properties (blood viscosity reduction, erythrocyte electrophoretic time shorten); 4. microcirculation improvement

Two, promote the reparation and the regeneration of tissue

1, promote the reparation and the treatment of regeneration red sage formulation of tissue: necrotic myocardium is removed fast; Fibroblast differentiation, collagen fiber form more obvious; Granulation forms comparative maturity.Local congestion alleviates, blood circulation improves, and healing time shortens.

2, the inhibition hyperplasia has inhibitory action to the fibroblast of hyperplasia.

Three, protect the liver and improve the liver microcirculation.

Four, contain cryptotanshinone, dihydrotanshinone in the antibiotic red sage formulation, external staphylococcus, escherichia coli, degeneration bacillus are had inhibitory action.

Herba Hedyotidis Diffusae, the Herba Hedyotidis Diffusae formal name used at school: Hedyotis diffusa is the plant of Rubiaceae cerastium.Its Chinese patent medicine bitter in the mouth, light, cold in nature.Main effect is heat-clearing and toxic substances removing, medicinal powder for relieving pain knot, promoting urination to remove dampness.Outstanding kind treatment all kinds inflammation has than strong inhibitory action the tumor cell of acute lymphoblastic type, granulocyte type, monocyte type and chronic granulocyte type at external (quite crude drug 6g/ml).

The Radix Paeoniae Alba; Radix Paeoniae Alba (formal name used at school: Paeonia sterniana Fletcher in Journ.) also claim Paeonia sterniana Fletcher in Journ.; it is Ranunculaceae Paeonia plant; pharmacological action: 1; effect to cardiovascular system: the Radix Paeoniae Alba has coronary artery dilator; the effect of bringing high blood pressure down (d-cachou extract and progallin A have antithrombotic and antiplatelet aggregative activity); 2; liver protection effect: the Radix Paeoniae Alba is to carbon tetrachloride; AFB1; hepatic injury has obvious protective effect due to the D-galactosamine; 3; spasmolysis: the Radix Paeoniae Alba has inhibitory action to intestinal tube and stomach on the throne motion; can significantly resist the uterine contraction that oxytocin causes; 4; analgesic activity: the Radix Paeoniae Alba can suppress mouse writhing; shout; the hot plate reaction; morphine is suppressed writhing response synergism is arranged; and can resist and faint from fear 5 due to the pentylenetetrazole; antibacterial action.The Radix Paeoniae Alba has protective effect to liver; Radix Paeoniae Alba extract raises to hepatic injury due to the D-galactosamine and SGPT tangible antagonism; SGPT is reduced; and making hepatocellular pathological changes and downright bad recovery normally. the lactic acid dehydrogenase that the rat acute hepatic injury that the ethanol extraction of the Radix Paeoniae Alba can make aflatoxin B1 cause is showed and the gross activity of isozyme raise and are minimized. and white peony root's total glycoside can suppress carbon tetrachloride induced mice Plasma glutamate-pyruvate transaminase and lactic acid dehydrogenase raises; and liver organization bitten acid denaturation; necrosis has certain antagonism. and the someone thinks; hepatic injury due to the carbon tetrachloride is to destroy because of membrane structure generation peroxidation; make glutamate pyruvate transaminase and lactic acid dehydrogenase rising in the blood; white peony root's total glycoside may have protective effect to hepatocyte injury, therefore the transaminase is reduced.

Radix Aconiti Lateralis Preparata, Radix Aconiti Lateralis Preparata are the processed goods of the daughter root of ranunculaceae plant Aconitum carmichjaelii Debx. aconitum carmichaeli debx..Meridian distribution of property and flavor: hot, sweet, big heat; Poisonous.GUIXIN, kidney, spleen channel.Function cures mainly: recuperating depleted YANG and rescuing the patient from collapse, it is supporing yang to mend fire, dispersing cold for relieving pain." for the recuperating depleted YANG and rescuing the patient from collapse first product medicine ", Radix Aconiti Lateralis Preparata has recuperating depleted YANG and rescuing the patient from collapse, and it is supporing yang to mend fire, by the effect of wind-cold damp pathogen.Cure mainly the YANG-depletion collapse, the cold extremities faint pulse, sexual impotence, cold womb, trusted subordinate's cold type of pain, deficiency and coldness is vomited and diarrhoea, YIN-cold edema, arthralgia due to cold-dampnes etc." book on Chinese herbal medicine converges and says " cloud: " Radix Aconiti Lateralis Preparata, recuperating depleted YANG gas, the YIN-cold of loosing.The time of all genus yang deficiency negative electrodes, the heat syndrome person of lung kidney unit, clothes dead distinguished service arranged ".Radix Aconiti Lateralis Preparata can strengthen myocardial contraction, accelerates heart rate, increases cardiac output, increases myocardial oxygen consumption.Adopt Chinese medicine serum pharmacological research method, after observing oral Radix Aconiti Lateralis Preparata crude preparation by using, animal serum has obvious enhancing myocardial contraction and accelerates the effect of myocardial contraction speed, administration after 2 hours the effect of pastille serum reach the peak, show and really close the heart tonifying composition in the Radix Aconiti Lateralis Preparata decocting liquid, and this composition is oral effectively.The Radix Aconiti Lateralis Preparata over administration can cause arrhythmia.

The Radix Rehmanniae, the Radix Rehmanniae is the fresh or dried root of Scrophulariaceae herbaceos perennial Radix Rehmanniae Rehmannia glutinosa Libosch., the branch that Radix Rehmanniae, Radix Rehmanniae and Radix Rehmanniae Preparata are arranged according to the different people medicine of concocting method, the effect of different processed products emphasizes particularly on different fields, Radix Rehmanniae is cold in nature, sweet-bitter flavor, energy clearing away heat and promoting production of body fluid, the effect that cooling blood for hemostasis, tonifying YIN promote the production of body fluid.Radix Rehmanniae is cold in nature, sweet in the mouth, energy clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting; The Radix Rehmanniae Preparata slightly warm in nature, sweet in the mouth, the energy nourishing YIN and supplementing blood, beneficial essence is filled out marrow.Li Shizhen (1518-1593 A.D.) to the evaluation of Radix Rehmanniae is: " one hundred days of clothes are rosy cheeks, make light of one's life by commiting suicide not old in 3 years." meridian distribution of property and flavor: Radix Rehmanniae sweet in the mouth, hardship, cold in nature.GUIXIN, liver, lung meridian.Function cures mainly: have the clearing away heat and cooling blood effect and be used for the warm febrile disease blood of joining the army, high fever coma, xerostomia crimson tongue.As qingying decoction.Control the epidemic febrile disease later stage, waste heat to the greatest extent, do not hinder by cloudy liquid, night fever abating at dawn, and red tongue rapid pulse person is as QINGHAOBIEJIATANG.Can be used for controlling the warm febrile disease blood of joining the army, the heat in blood poison is contained, hematemesis and epistaxis, and macule is purple black.As Sisheng Wan; It is thirsty that the YIN nourishing and the production of body fluid promoting effect is used for Tianjin wound, and interior-heat is quenched one's thirst.Control the epidemic febrile disease impairment of YIN, the dryness of the intestine constipation is as Zengye Tang.Chemical constituent mainly contains oligosaccharide, polysaccharide, iridoid glycoside, aminoacid etc. in the Radix Rehmanniae, and they are material bases of Radix Rehmanniae pharmacological action.

Fructus Lycii, Fructus Lycii of the present invention is a Fructus Lycii, is the dry mature fruit of plant of Solanaceae lycium barbarum Lycium barbarum L..Its sweet in the mouth, property are put down has the effect of the liver and the kidney tonifying, says in the Compendium of Material Medica that " obey hard muscles and bones for a long time, it is not old to make light of one's life by commiting suicide, cold-resistant summer-heat." traditional Chinese medical science commonly used it treat hepatic and renal YIN deficiency, soreness of the waist and knees, dizziness, forgetful, dizzy, many tears of blurred vision, quench one's thirst, disease such as seminal emission.The effect of aspects such as modern pharmacology studies confirm that Fructus Lycii scalable body's immunity, can effectively suppress tumor growth and cell mutation, has slow down aging, anti-fatty liver, blood lipid regulation and blood glucose, promotion hemopoietic function, and be applied to clinical.1. pairs of Immune Effects of the pharmacological action of Qi: the enhancing non-specific immunity effect is arranged, mouse gavaging Fructus Lycii water extract or intramuscular injection alcohol extract and lycium barbarum polysaccharide, the phagocytic function of macrophage is improved, strengthen the effect of serum lysozyme, improve tiring of anti-sheep red blood cell (SRBC) antibody in the serum, can also increase the quantity of the antibody forming cell of anti-sheep red blood cell (SRBC) in the Mus spleen.2, Fructus Lycii has delaying senility function, and fructus lycii extracted solution 0.5mg/kg mouse stomach can obviously suppress liver LPo totally on the 20th and generate, and blood two-story valley peptide peroxidase (GSH-Px) vigor and erythrocyte superoxide dismutase (SOD) vigor are improved; Human trial shows that can obviously suppress serum LPo generates, and makes that the GSH-Px vigor increases in the blood, but the erythrocyte sod vigor is not seen rising, and the prompting fructus lycii extracted solution has delaying senility function.3, the anti-liver injury effect of Fructus Lycii: Fructus Lycii can make the phospholipid in the rat blood serum regulating liver-QI obviously increase; rat phospholipid due to the carbon tetrachloride descends and cholesterol raises has significant protective effect to giving for a long time; water solubility extract also has similar effect, but slightly.4, hypoglycemic activity: wolfberry fruit extract can significantly and lastingly reduce rat blood sugar, increase carbohydrate tolerance, and toxicity is less.In addition, this product also has effects such as antitumor, promotion hemopoietic function.5, function for tonifying kidney effect, there is the expert to discuss: after using lycium barbarum polysaccharide, vitamin E-antiaging agents such as C mixture, the change of old hamster kidney cell mitochondria ultrastructure, ATP synthetic quantity and lipid peroxidation product malonaldehyde level, find that the mitochondrial 26S Proteasome Structure and Function variation of old Ren Mus is accompanied by increasing of Radical Metabolism product malonaldehyde, young group 18.75nM/mgPrmin is low for old hamster kidney cell mitochondrial ATP synthetic quantity, is 120.38nM/mgPrmin ± 16.72nM/mgPrmin; And the nephridial tissue malonaldehyde is 2.4 times of young group, is 30.40 μ g/100mg ± 6.66 μ g/100mg weight in wet bases.Take vitamin E-C mixture or lycium barbarum polysaccharide for a long time and all can play effect to free radical resisting to a certain extent, nephridial tissue malonaldehyde level is descended, the prevention mitochondrion is aging, and its function is made moderate progress.6, protect the liver function, limit synthetic fibre, Shen new life, Wang Yanrong, Guo Fengying, Zhang Yan discuss in the morphology research of lycium barbarum polysaccharide to carbon tetrachloride induced mice hepatic injury repair: 48 male Kunming kind white mice are divided into 4 groups, and the hepatic injury group (12) give CCl4 subcutaneous injection; Hepatic injury saline group (12) is irritated stomach 7d with normal saline except that giving CCl4; Matched group (12) subcutaneous injection normal saline, tap water are irritated stomach.Treatment group is as a result compared with damage group and damage saline group, the lobules of liver damage field dwindles, fat drips minimizing in the hepatocyte, nucleus increases, RNA and kernel increase, and glycogen increases, SDH, G-6-Pase increased activity, rough endoplasmic reticulum recovers the bottle type to be arranged, and the mitochondrion morphosis recovers, quantity increases.Show that lycium barbarum polysaccharide has repair to hepatic injury, its mechanism may be by stoping the damage of endoplasmic reticulum, promote protein synthesis and Detoxication, recovering hepatocellular function, and promote hepatocellular regeneration.7, lipotropy: the betanin in long-term (75 days) the oral fruit of rat, the phospholipid level in can raise blood and the liver; Take betanin in advance or simultaneously and can resist the attenuating of phospholipid, total cholesterol level in the rats'liver that carbon tetrachloride causes, and increase; BSP, SGP-T, alkaline phosphatase lipase, acetylcholine esterase etc. all there is the improvement effect.Mainly be that betanin plays the methyl supplying in vivo.8, to the effect of blood pressure, fruit water solubility extract 20mg/kg intravenous injection can make the anesthetized rabbit blood pressure reduce, and breathes excited; Injecting atropine cuts off the both sides vagus nerve can eliminate its hypotensive effect; Extrasomatic rabbit heart is inhibitory action, and makes rabbit ear vasoconstriction, methanol, acetone and other organic solvent extract also have slight hypotensive effect.9, antifatigue effect, Fructus Lycii decoct are to the influence of mice hydroxyproline content and anoxia enduring and antifatigue effect: hydroxyproline (Hydroxyproline) is the seed amino acid in collagen fiber and the protein, is the proline hydroxylation.Human body is in aging course, because oxygen is under-supply, influences the dihydroxylation process of proline, thereby causes in old people's the collagen hydroxyproline content low, and main organs is dwindled distortion, weight saving.Because pulmonary function is influenced, vital capacity descends, and reserve capabillity reduces, and resistance goes down, and muscular strength descends, and anoxia enduring, anti-fatigue ability descend.Fructus Lycii decoct (13.23% concentration) gives mouse stomach 0.3ml/20g, every day 1 time, after 30 days hydroxyproline concentration with compare increment rate and reach 15.49%.The Fructus Lycii decoct gives its hypoxia-bearing capability of mouse peritoneal injection 0.3ml/20g and compared in 27.9 ± 1.3 minutes with the matched group life span, and Fructus Lycii is 37.5 ± 2.5 minutes (P＜0.01).The resisting fatigue experimental and control more also has the difference (P＜0.01) of highly significant.10, antitumor action, in vitro tests show that Fructus Lycii, leaf are to people's adenocarcinoma of stomach KATo-III cell, Chinese wolfberry carpopodium, leaf all have obvious inhibitory action to the human cervical carcinoma Hela cell, its mechanism of action shows that mainly suppressing cell DNA synthesizes, the interference cell division, and cell is grown ability drop again.Fructus Lycii lyophilized powder suspension and cyclophosphamide combined medication, treatment rat Walker carcinosarcoma 256 finds that its leukopenia that cyclophosphamide is caused has obvious protective effect.11, in addition, Fructus Lycii and betanin have protective effect to the hepatic injury that CCl4 causes.

Radix Glycyrrhizae Preparata, Radix Glycyrrhizae Preparata are the root of leguminous plant (RADIX GLYCYRRHIZAE PREPARATA), and Radix Glycyrrhizae Preparata is the Radix Glycyrrhizae of smoking with honey.Function with cure mainly: spleen reinforcing stomach function regulating, Yiqi and vein recovery.Be used for weakness of the spleen and stomach, fatigue and weakness, severe palpitation, irregularly intermittent and regularly intermittent pulse can be separated the Radix Aconiti Lateralis Preparata poison.Main effect: nourishing YIN, enrich blood, negative and positive and transferring.

More than all medicines share, benefiting QI for activating blood circulation, dispersing the stagnated live-QI to relieve the stagnation of QI, clearing heat and expelling damp, reinforcement and elimination in combination, giving consideration to both the incidental and fundamental is played the function of nourishing YIN and benefiting blood, promoting blood circulation and stopping pain and adjusting viscera function imbalance altogether, and viral chronic hepatitis B is had curative effect preferably.

Again from the another one angle, Chinese medicine is that China's tradition is used for the important weapon of disease preventing and treating, in recent years, people find and develop some medicines that treatment hepatitis is arranged from Chinese medicine, the inventor is through having carried out more deep research to Chinese medicine ingredients and mechanism of action thereof, and the existing just viral treatment chronic hepatitis B of the Chinese medicine of the present invention mechanism of action is summarized as follows:

1, the hepatitis virus resisting antiviral is the key problem and the key link of treatment hepatitis.The effective hepatitis virus resisting medicine of screening is a shortcut of seeking the active drug of high specificity from traditional natural drug.This class medicine mainly contains Radix Et Rhizoma Rhei, Radix Salviae Miltiorrhizae, Flos Lonicerae, Radix Scutellariae, Rhizoma Coptidis, Herba Scutellariae Barbatae, gives birth to strain under fiber crops, Herba Houttuyniae, Radix Sanguisorbae, Folium Isatidis, Fructus Forsythiae, Semen Caesalpiniae Minacis, the leaf, Radix Puerariae, Fructus Chaenomelis, Herba Silybi mariani, Radix Arnebiae (Radix Lithospermi), Herba Artemisiae Annuae, Fructus Gardeniae etc.Show that according to relevant test they can suppress HBsAg, HBV-DNAP, degraded HBV-DNA.

2, improve to recover the many Chinese medicines of liver function the effect of clearly and significantly improving liver function is arranged. mainly show and fall enzyme, promoting the function of the gallbladder to alleviate jaundice, improve aspect such as Proteometabolism.Chinese medicine mainly contains as Fructus Schisandrae Chinensis, Radix Et Rhizoma Rhei, Radix Isatidis, Radix Glycyrrhizae, Radix Sophorae Flavescentis, Herba Artemisiae Scopariae, Radix Sophorae Tonkinensis, Folium Isatidis, Radix Polygoni Multiflori, Fructus Lycii, Herba Taraxaci, Fructus Forsythiae, Caulis Lonicerae, Radix Salviae Miltiorrhizae, Polyporus, Rhizoma Polygoni Cuspidati etc.

3, the effect of adjusting immunologic function Chinese herbal medicine enhance immunity gains public acceptance. and it can strengthen macrophage, T and B cell function. improve immunoglobulin. remove immune complex.Having the immunoreactive Chinese medicine of adjusting mainly comprises: Ganoderma, Radix Sophorae Tonkinensis, Caulis Spatholobi, the Radix Paeoniae Alba, cattle rattan, Fructus Schisandrae Chinensis, Radix Arnebiae (Radix Lithospermi), Fructus Ligustri Lucidi, Radix Rehmanniae, Rhizoma Dioscoreae, Radix Ophiopogonis, Herba Cistanches, Radix Scutellariae, Rhizoma Coptidis, Herb Gynostemmae Pentaphylli, Poria, Lentinus Edodes, Radix Curcumae, Semen Cuscutae etc.

4, anti-hepatic fibrosis Chinese medicine is being suppressed to fibrocellular activity, is suppressing the generation of collagen and is promoting the aspects such as degraded of collagen all to have certain effect.The most frequently used Chinese herbal medicine has Radix Salviae Miltiorrhizae, Radix Et Rhizoma Rhei, Radix Glycyrrhizae, Semen Persicae, Radix Notoginseng, Radix Angelicae Sinensis, Rhizoma Polygoni Cuspidati, Rhizoma Chuanxiong, Fructus Crataegi, Cordyceps, Radix Paeoniae Rubra, Carapax Trionycis, Rhizoma Curcumae, Flos Carthami, Radix Angelicae Sinensis, Radix Stephaniae Tetrandrae, Radix Bupleuri etc.

So, Chinese medicine preparation of the present invention has been followed whole existing the thought and the determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs principle of motherland's medical science, the rule of development takes place in research and inquirement hepatitis, and adopts blood circulation promoting and blood stasis dispelling, hard masses softening and resolving, heat-clearing and toxic substances removing, the body resistance strengthening and constitution consolidating etc. to have " operation " means of Chinese medicine characteristic, accomplishes " medication is as using military forces ", could " know yourself as well as the enemy; victorious in every battle ", in the assault of fortified positions of going on an expedition hepatitis, handy, set up outstanding service, make Chinese medicine demonstrate immeasurable huge effect.

The Chinese medicine preparation that the present invention treats chronic hepatitis B can add filler or the solution that meets medical standard, make medically solid preparation or liquid preparation, for example tablet, capsule, granule, pill, oral liquid or syrup etc., below introduce the preparation method of several dosage forms respectively:

The solid preparation preparation method is as follows:

Get Radix Salviae Miltiorrhizae, Radix Glycyrrhizae Preparata is crushed into powder, and is standby; Radix Bupleuri, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Flos Carthami, Radix Salviae Miltiorrhizae, Herba Hedyotidis Diffusae, the Radix Rehmanniae, Fructus Lycii and Radix Aconiti Lateralis Preparata are smashed, and per kilogram rises the ethanol extraction twice that volumetric concentration is 50-90% with 5-8, and merge extractive liquid, reclaims ethanol then, obtain the molten dried cream of alcohol, and be standby; Filtration back medicinal residues add water 3-5 by weight and doubly boiled 3-5 hour, it is the water-soluble dried cream of 1.1-1.2 that filtering solution concentration becomes proportion, again with above-mentioned pure molten dried cream and Danshen Root merging, mix homogeneously, add adjuvant, make the solid preparation product, described solid preparation product comprises capsule, granule, tablet.Perhaps add sucrose or Mel, mix homogeneously is made pill.

Described adjuvant is the pharmaceutic adjuvant of various medical standard universals, comprises filler, disintegrating agent, lubricant etc., and filler is starch, dextrin, carboxymethyl starch, calcium hydrogen phosphate, sucrose, Momordia grosvenori aglycone and other pharmaceutic adjuvants; Disintegrating agent is Sodium Tvlose, hydroxypropyl cellulose and pharmaceutic adjuvant with water swelling; Lubricant is the pharmaceutic adjuvant of Polyethylene Glycol, magnesium stearate, Pulvis Talci and tool lubrication.Wherein the weight content of filler, disintegrating agent, lubricant is respectively 30-55%, 3-15%, 0.3%-0.6%.

The manufacture method of liquid preparation is as follows:

Getting Radix Salviae Miltiorrhizae, Radix Glycyrrhizae Preparata, Radix Bupleuri, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Flos Carthami, Radix Salviae Miltiorrhizae, Herba Hedyotidis Diffusae, the Radix Rehmanniae, Fructus Lycii and Radix Aconiti Lateralis Preparata smashes, per kilogram rises the ethanol extraction twice that volumetric concentration is 50-90% with 5-8, and merge extractive liquid, reclaims ethanol then, obtain the molten dried cream of alcohol, standby; Medicinal residues add water 3-5 by weight and doubly boiled 3-5 hour, and it is the water-soluble dried cream of 1.1-1.2 that filtering solution concentration becomes proportion, merge with the above-mentioned pure molten dried cream that obtains again, be diluted to suitable concentration, add an amount of sucrose, Momordia grosvenori aglycone and food antiseptics, make liquid preparation, obtain product.

Substantive distinguishing features of the present invention and obvious improvement are:

1, the present invention on prescription from the traditional Chinese medical science pathological characteristic of hepatopathy, the principle-method-recipe-medicines principle that meets differentiation of tcm, used for reference the achievement of Chinese medicine modern pharmacological research simultaneously, and according to modern study achievement screening of medicaments and prescription, and the Chinese medicine preparation of the treatment hepatopathy determined curative effect that obtains, can be described as one and both possessed traditional Chinese medical science tradition prescription characteristic, the prescription of the treatment hepatitis b liver disease of combination of Chinese and Western medicine characteristics is arranged again.

2, function of the present invention is existing eliminating evil, and the replenishing QI to invigorate the spleen of holding concurrently again reaches eliminating evil and just do not hinder.But it is monarch drug removing summer-heat hepatopathy noxious dampness that prescription is selected Radix Bupleuri for use; Herba Hedyotidis Diffusae, Flos Carthami, Radix Salviae Miltiorrhizae are ministerial drug, can assist monarch drug eliminating evil and take healthy energy into account; Fructus Lycii, be the removing dampness of adjuvant drug QI invigorating from art, blood circulation promoting and blood stasis dispelling and just not hindering stagnates with the stasis of blood of going in the liver.The medicine compatibility of respectively distinguishing the flavor of in the side is proper, and the monarch compatibility is precise and appropriate, plays the detoxification and promoting urination blood stasis dispelling altogether, and replenishing QI to invigorate the spleen is set upright the merit of hepatoprotective.

The specific embodiment

Below be embodiments of the invention:

Embodiment one: get following parts by weight of traditional Chinese medicines raw material: 8 kilograms of Radix Bupleuri, 8 kilograms of the Rhizoma Atractylodis Macrocephalaes, 5 kilograms of the Radix Paeoniae Albas, 2 kilograms on Flos Carthami, 15 kilograms of Radix Salviae Miltiorrhizaes, 15 kilograms of Herba Hedyotidis Diffusaes, 5 kilograms in the Radix Rehmanniae, 5 kilograms of Fructus Lyciis, 2 kilograms of Radix Aconiti Lateralis Preparatas, 2 kilograms of Radix Glycyrrhizae Preparatas.Adjuvant is 30 kilograms of starch, 10 kilograms of Sodium Tvlose, 5 kilograms of Polyethylene Glycol.

Get Radix Salviae Miltiorrhizae, Radix Glycyrrhizae Preparata is crushed into powder, and is standby; Radix Bupleuri, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Flos Carthami, Radix Salviae Miltiorrhizae, Herba Hedyotidis Diffusae, the Radix Rehmanniae, Fructus Lycii and Radix Aconiti Lateralis Preparata are smashed, and per kilogram rises the ethanol extraction twice that volumetric concentration is 50-90% with 5-8, and merge extractive liquid, reclaims ethanol then, obtain the molten dried cream of alcohol, and be standby; Filtration back medicinal residues add water 3-5 by weight and doubly boiled 3-5 hour, and it is the water-soluble dried cream of 1.1-1.2 that filtering solution concentration becomes proportion, and with above-mentioned pure molten dried cream and Danshen Root merging, mix homogeneously adds adjuvant, makes capsule again.

Embodiment two:

Get following parts by weight of traditional Chinese medicines raw material: 10 kilograms of Radix Bupleuri, 10 kilograms of the Rhizoma Atractylodis Macrocephalaes, 8 kilograms of the Radix Paeoniae Albas, 5 kilograms on Flos Carthami, 10 kilograms of Radix Salviae Miltiorrhizaes, 20 kilograms of Herba Hedyotidis Diffusaes, 8 kilograms in the Radix Rehmanniae, 10 kilograms of Fructus Lyciis, 4 kilograms of Radix Aconiti Lateralis Preparatas, 3 kilograms of Radix Glycyrrhizae Preparatas.Adjuvant is that 25 kilograms of carboxymethyl starches, carboxy-propyl cellulose are received 10 kilograms of 10 kilograms, Pulvis Talci,

Get Radix Salviae Miltiorrhizae, Radix Glycyrrhizae Preparata is crushed into powder, and is standby; Radix Bupleuri, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Flos Carthami, Radix Salviae Miltiorrhizae, Herba Hedyotidis Diffusae, the Radix Rehmanniae, Fructus Lycii and Radix Aconiti Lateralis Preparata are smashed, and per kilogram rises the ethanol extraction twice that volumetric concentration is 50-90% with 5-8, and merge extractive liquid, reclaims ethanol then, obtain the molten dried cream of alcohol, and be standby; Filtration back medicinal residues add water 3-5 by weight and doubly boiled 3-5 hour, and it is the water-soluble dried cream of 1.1-1.2 that filtering solution concentration becomes proportion, and with above-mentioned pure molten dried cream and Danshen Root merging, mix homogeneously adds adjuvant, makes tablet again.

Embodiment three:

Get following parts by weight of traditional Chinese medicines raw material: 15 kilograms of Radix Bupleuri, 15 kilograms of the Rhizoma Atractylodis Macrocephalaes, 12 kilograms of the Radix Paeoniae Albas, 8 kilograms on Flos Carthami, 12 kilograms of Radix Salviae Miltiorrhizaes, 25 kilograms of Herba Hedyotidis Diffusaes, 12 kilograms in the Radix Rehmanniae, 12 kilograms of Fructus Lyciis, 8 kilograms of Radix Aconiti Lateralis Preparatas, 8 kilograms of Radix Glycyrrhizae Preparatas.Adjuvant is 80 kilograms of sucrose, 2 kilograms of Momordia grosvenori aglycones, 10 kilograms of Sodium Tvlose, 10 kilograms of Polyethylene Glycol.

Get Radix Salviae Miltiorrhizae, Radix Glycyrrhizae Preparata is crushed into powder, and is standby; Radix Bupleuri, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Flos Carthami, Radix Salviae Miltiorrhizae, Herba Hedyotidis Diffusae, the Radix Rehmanniae, Fructus Lycii and Radix Aconiti Lateralis Preparata are smashed, and per kilogram rises the ethanol extraction twice that volumetric concentration is 50-90% with 5-8, and merge extractive liquid, reclaims ethanol then, obtain the molten dried cream of alcohol, and be standby; Filtration back medicinal residues add water 3-5 by weight and doubly boiled 3-5 hour, and it is the water-soluble dried cream of 1.1-1.2 that filtering solution concentration becomes proportion, again with above-mentioned pure molten dried cream and Danshen Root merging, with sucrose, Momordia grosvenori aglycone, Sodium Tvlose, Polyethylene Glycol, mix homogeneously is made granule.

Embodiment four:

Get following parts by weight of traditional Chinese medicines raw material: 12 kilograms of 10 kilograms of Rhizoma Atractylodis Macrocephalaes of Radix Bupleuri, 10 kilograms of the Radix Paeoniae Albas, 4 kilograms on Flos Carthami, 10 kilograms of Radix Salviae Miltiorrhizaes, 20 kilograms of Herba Hedyotidis Diffusaes, 8 kilograms in the Radix Rehmanniae, 10 kilograms of Fructus Lyciis, 3 kilograms of Radix Aconiti Lateralis Preparatas, 6 kilograms of Radix Glycyrrhizae Preparatas.Adjuvant is 50 kilograms of sucrose, 2 kilograms of Mel, 20 kilograms in dextrin, 10 kilograms of Polyethylene Glycol.

Get Radix Salviae Miltiorrhizae, Radix Glycyrrhizae Preparata is crushed into powder, and is standby; Radix Bupleuri, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Flos Carthami, Radix Salviae Miltiorrhizae, Herba Hedyotidis Diffusae, the Radix Rehmanniae, Fructus Lycii and Radix Aconiti Lateralis Preparata are smashed, and per kilogram rises the ethanol extraction twice that volumetric concentration is 50-90% with 5-8, and merge extractive liquid, reclaims ethanol then, obtain the molten dried cream of alcohol, and be standby; Filtration back medicinal residues add water 3-5 by weight and doubly boiled 3-5 hour, and it is the water-soluble dried cream of 1.1-1.2 that filtering solution concentration becomes proportion, with above-mentioned pure molten dried cream and Danshen Root merging, add adjuvant again, make pill.

Embodiment five: get following parts by weight of traditional Chinese medicines raw material: 20 kilograms of Radix Bupleuri, 20 kilograms of the Rhizoma Atractylodis Macrocephalaes, 15 kilograms of the Radix Paeoniae Albas, 10 kilograms on Flos Carthami, 15 kilograms of Radix Salviae Miltiorrhizaes, 30 kilograms of Herba Hedyotidis Diffusaes, 15 kilograms in the Radix Rehmanniae, 15 kilograms of Fructus Lyciis, 10 kilograms of Radix Aconiti Lateralis Preparatas, 10 kilograms of Radix Glycyrrhizae Preparatas.Adjuvant is 50 kilograms of sucrose, 2 kilograms of Momordia grosvenori aglycones.

Getting Radix Salviae Miltiorrhizae, Radix Glycyrrhizae Preparata, Radix Bupleuri, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Flos Carthami, Radix Salviae Miltiorrhizae, Herba Hedyotidis Diffusae, the Radix Rehmanniae, Fructus Lycii and Radix Aconiti Lateralis Preparata smashes, per kilogram rises the ethanol extraction twice that volumetric concentration is 50-90% with 5-8, and merge extractive liquid, reclaims ethanol then, obtain the molten dried cream of alcohol, standby; Medicinal residues add water 3-5 by weight and doubly boiled 3-5 hour, and it is the water-soluble dried cream of 1.1-1.2 that filtering solution concentration becomes proportion, merge with the above-mentioned pure molten dried cream that obtains again, be diluted to suitable concentration, add sucrose, Momordia grosvenori aglycone and proper amount of edible antiseptic, make oral liquid, obtain product

Embodiment six; Get following parts by weight of traditional Chinese medicines raw material: 12 kilograms of 10 kilograms of Rhizoma Atractylodis Macrocephalaes of Radix Bupleuri, 10 kilograms of the Radix Paeoniae Albas, 4 kilograms on Flos Carthami, 10 kilograms of Radix Salviae Miltiorrhizaes, 20 kilograms of Herba Hedyotidis Diffusaes, 8 kilograms in the Radix Rehmanniae, 10 kilograms of Fructus Lyciis, 3 kilograms of Radix Aconiti Lateralis Preparatas, 6 kilograms of Radix Glycyrrhizae Preparatas.Adjuvant is 50 kilograms of sucrose, 2 kilograms of Momordia grosvenori aglycones.

Getting Radix Salviae Miltiorrhizae, Radix Glycyrrhizae Preparata, Radix Bupleuri, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Flos Carthami, Radix Salviae Miltiorrhizae, Herba Hedyotidis Diffusae, the Radix Rehmanniae, Fructus Lycii and Radix Aconiti Lateralis Preparata smashes, per kilogram rises the ethanol extraction twice that volumetric concentration is 50-90% with 5-8, and merge extractive liquid, reclaims ethanol then, obtain the molten dried cream of alcohol, standby; Medicinal residues add water 3-5 by weight and doubly boiled 3-5 hour, and it is the water-soluble dried cream of 1.1-1.2 that filtering solution concentration becomes proportion, merge with the above-mentioned pure molten dried cream that obtains again, be diluted to suitable concentration, add sucrose, Momordia grosvenori aglycone and proper amount of edible antiseptic, make oral liquid, obtain product.

Below be the application example of Chinese medicine preparation of the present invention:

The protective effect test of the rat chronic hepatic injury that CCl4 causes.

Reason: chronic hepatitis is the commonly encountered diseases and the frequently-occurring disease of China, it is again the underlying diseases that causes liver cirrhosis, it is significant to explore its treatment new method, the inventor tests discovery, the preparation made from Radix Salviae Miltiorrhizae, Radix Glycyrrhizae Preparata, Radix Bupleuri, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Flos Carthami, Radix Salviae Miltiorrhizae, Herba Hedyotidis Diffusae, the Radix Rehmanniae, Fructus Lycii and Radix Aconiti Lateralis Preparata.Protect the liver, antiinflammatory, human body immunity improving ability and anti-hepatic fibrosis, the effect of anti-apoptotic.This experiment is intended to observe the protective effect of its rat chronic hepatic injury that CCl4 is caused, and tentatively inquires into its mechanism of action.

1 material

1.1 medicine and reagent:

Bifendate drop pill: Beijing consonance pharmaceutical factory, lot number: 04060109.CCl ₄(analytical pure): the Shanghai Changjiang River chemical plant produces, and ALT, AST measure test kit: bio-engineering research institute, lot number: 20100409 are built up in Nanjing; TP, ALB measure test kit: bio-engineering research institute, lot number: 20100410 are built up in Nanjing; SOD, MDA measure test kit: bio-engineering research institute, lot number: 20100758 are built up in Nanjing; GSH-px measures test kit: bio-engineering research institute, lot number: 20100810 are built up in Nanjing.

1.2 animal:

Cleaning level Wistar rat, the male and female dual-purpose, body weight 200 ± 20g, Guangxi Medical University's Experimental Animal Center provides, credit number: osmanthus (moving) is betrothed to 2000 No. 001.

2 methods

2.1 animal grouping and processing:

Rat is divided into 6 groups at random: normal control group, model control group, positive controls.Experimental session is except that the normal control group, and each organizes rat by 3ml/kg (5ml/kg first) body weight back subcutaneous injection 40%CCl ₄Peanut oil solution, weekly twice, in continuous 8 weeks, cause the rat chronic hepatic injury.Weigh twice weekly, and adjust medicine and CCl successively ₄Dosage.Normal control group, model control group are irritated the stomach deionized water; The high, medium and low dosage group of the oral liquid of the embodiment of the invention five is irritated stomach 0.8g/kg, 0.4g/kg, 0.2g/kg respectively, and positive controls is irritated stomach 0.1g/kg bifendate drop pill, and administration two is 10ml/kg.

2.2 specimen is left and taken:

Behind the last administration 24h, frog board is rat fixedly, and the femoral artery sacrificed by exsanguination is got the preceding 12h fasting of blood and be can't help water.Separation of serum, cryopreservation; Get same position hepatic tissue and make 10% homogenate; Get hepatomegaly leaf 10% formaldehyde fixed.

2.3 index detects:

All detections all detect with U.S. Agilent8543 ultraviolet-uisible spectrophotometer; Detect all and undertaken by the test kit explanation.

2.4 liver histopathology procuratorial work:

Paraffin embedding, section, HE dyeing, light microscopic is observed hepatic tissue pathology down and is changed.Mark by following standard

(-) 1 minute: the lobules of liver structural integrity, hepatocyte is neat, and is no abnormal.

(+) 2 minutes: the degeneration of hepatocyte limitation, slight fibrosis, the necrosis of hepatocyte kitchen range shape has a small amount of cell infiltration.

(++) 3 minutes: the degeneration of hepatocyte diffusivity, necrosis, fibrosis, the lobules of liver structural change, the necrosis of hepatocyte limitation has more cell infiltration.

(+++) 4 minutes: the degeneration of hepatocyte diffusivity, necrosis, fibrosis is heavier, the heavy damage of lobules of liver structure, a large amount of cell infiltration.

2.5 statistical procedures:

Data with

Expression, mean difference is checked with t between two groups.

3 results

3.1 the oral liquid of the embodiment of the invention five is to the influence of rat CCl4 chronic hepatic injury serum alt, AST:

CCl ₄Chronic hepatic injury rat blood serum ALT, AST level obviously raise.Model control group rat blood serum Serum ALT, the normal matched group of AST level obviously raise P＜0.01.Compare with model group, positive controls, four medication groups of the high, medium and low dosage group of Mog all can significantly reduce CCl ₄Chronic hepatic injury rat blood serum ALT, AST level, P＜0.01 or P＜0.05.The results are shown in Table 1:

The oral liquid of table 1 embodiment of the invention five is to rat CCl ₄The influence of chronic hepatic injury serum alt, AST

* compare P＜0.05 with model control group; * and model control group be P＜0.01 relatively

3.2 the oral liquid g of the embodiment of the invention five is to rat CCl ₄The influence of ALB, TP, A/G in the chronic hepatic injury serum:

Compare with the normal control group, model control group serum ALB, TP content significantly reduce, and the A/G value also significantly reduces, P＜0.01.Positive controls serum ALB, TP content, A/G value have remarkable rising effect, P＜0.01.With each dosage group of oral liquid of the model control group comparison embodiment of the invention five ALB, TP content there are tangible rising effect P＜0.01 or P＜0.05.The results are shown in Table 2

The oral liquid of table 2 embodiment of the invention five is to the influence of ALB, TP, A/G in the rat CCl4 chronic hepatic injury serum

* compare P＜0.05 with model control group; * and model control group be P＜0.01 relatively

3.3 the oral liquid of the embodiment of the invention five is to rat CCl ₄The influence of SOD, MDA, GSH-px in the chronic hepatic injury liver tissue homogenate:

Compare with the normal control group, SOD, GSH-px level significantly reduce in the model control group rat liver homogenate; The MDA level raises, P＜0.01; Significantly raise with SOD, GSH-px level in the model control group comparison positive controls rat liver homogenate, the MDA level significantly reduces P＜0.01; The remarkable increased SOD of each dosage group energy of oral liquid, GSH-px level with the model control group comparison embodiment of the invention five reduce the MDA level, P＜0.01 or P＜0.05.The results are shown in Table 3

Table 3 Mog is to the influence of SOD, MDA, GSH-px in the rat CCl4 chronic hepatic injury liver tissue homogenate

* compare P＜0.05 with model control group; * and model control group be P＜0.01 relatively

3.4 the oral liquid of the embodiment of the invention five is to rat CCl ₄The influence of chronic hepatic injury liver histopathology:

Model group liver tissues of rats normal configuration is destroyed, and collagen contents increases, and tangible fiber is arranged every formation, liver rope arrangement disorder, and the lobules of liver structure is obviously destroyed.Have clear improvement with each dosage group pathological tissue of oral liquid of model group comparison positive controls, the embodiment of the invention five, see Table 4.

The oral liquid of table 9 embodiment of the invention five is to CCl ₄The pathological influence of chronic hepatic injury liver tissues of rats

* compare P＜0.05 with model group; * and model group be P＜0.01 relatively

4. discuss:

The oral liquid of our the previous experiments proof embodiment of the invention five is to mice CCl ₄Hepatic injury, bacillus calmette-guerin vaccine add that immunologic liver injury has protective effect due to the lipopolysaccharide associating.Therefore we carry out the oral liquid of the embodiment of the invention five to rat CCl ₄The experimentation of chronic hepatic injury protective effect, experimental result confirm that the oral liquid of the embodiment of the invention five is to rat CCl ₄Chronic hepatic injury has protective effect.The oral liquid of the embodiment of the invention five can reduce serum alt, AST activity; Rising TP, ALB; Rising hepatic tissue SOD, GSH-px activity reduce hepatic tissue MDA content; Improving hepatic tissue pathology changes.Its mechanism may be relevant with its anti peroxidation of lipid, and concrete mechanism remains further to be studied.

The treatment example.

Case 1, Chen, the man, 45 years old, the worker of Nanning city enterprise found abdominal pain in 2009, flatulence pain all day, the soreness of waist does not feel like eating, first visit on November 10 in 2009.Survey report is that (TBIL 18.21, and TP 65.26, and ALT 192, AST58).Be diagnosed as Type B viral hepatitis, adopt the capsule of the embodiment of the invention 1,3 grams of taking medicine every day, continuous 30 days, abdominal pain, the symptom of flatulence disappears substantially, takes medicine 30 days again to consolidate curative effect, can go to work at present.

Case 2, Lee * *, the woman, nineteen fifty-nine gives birth to, the teacher of Liuzhou technical school, in December, 2008 is to hospital outpatient, the readme hepatalgia, the skin light yellow complexion is diagnosed as Type B viral hepatitis through checking (HBV-DNA 3.82 * 104, TBIL21.82, AST 128).Develop the Chinese medicine preparation (granule) of bright embodiment 3, each 1 bag, every bag 1 gram, boiled water is taken after mixing it with water, and three times on the one, hepatalgia transference cure after taking medicine 20 days, face begins to occur ruddy.

Case 3, patient's Wei, man, 45 years old, Nanning people from city, in June, 2010 conscious abdominal part distending pain, at Liuzhou workers' hospital's hospitalization, (TP 71.22, and ALB 30.22 to check Type B viral hepatitis, ALT 98.37, and AST 52), once took the other drug commentaries on classics of not getting better, the tablet of the back clothes embodiment of the invention 2, each 3, boiled water is taken after mixing it with water, three times on the one, serve on 40 days after, transference cure recovery from illness.

The inventor thinks because chronic hepatitis B brings serious harm to the mankind, how Chinese scholars reduces the harm of hepatitis B, and the aspect is constantly explored.Chinese medicine is having unique curative effect in treatment aspect the chronic hepatitis B, and some Chinese medicine has the resultant effect of multipath, multi-level, many target spots.Along with the laboratory detection means day by day accurately and perfect, also more and more to the evaluation index of hepatitis curative effect, can provide reference frame for Chinese medicine hepatitis effect by the variation of observing these indexs.Traditional detection index such as ALT, AST, A/G and cheap being widely used of serum of hepatitis B mark (HBVM), but lack susceptiveness, often liver pathological changes has reached certain degree when these indexs change.Molecular Biological Detection such as gene chip detect to as if viral nucleic acid, can go out virus from the gene level earlier detection.But the biochip technology development time is shorter, and technology is still immature, can't get around the step of sample amplification such as this technology, and this has weakened its advantage to a certain extent; And for the HBeAg titre lower or HBeAg negative patients, at present the chip of design still can not detect fully, illustrates that its sensitivity is high not enough.Single index often can not reflect liver function, hepatocyte damage situations comprehensively in the diagnosis index of hepatitis and Chinese medicine therapeutic evaluation, therefore should adopt many indexs observations when estimating liver function and Chinese medicine curative effect.The Chinese medicine that the optional usefulness of different phase that develops in hepatitis has the specific therapy effect is for clinical application provides guidance.Chinese medicine preparation of the present invention is the Chinese medicine of multi-functional treatment chronic hepatitis B, not only has the effect of the expelling pathogenic factors from the exterior that induces sweat, and functions such as removing pathogenic heat from blood and toxic substance from the body, removing dampness function of gallbladder promoting, saturating network detumescence, benefiting QI for activating blood circulation, dispersing the stagnated live-QI to relieve the stagnation of QI are arranged, and can treat recovery from illness.

Claims (5)

1. Chinese medicine preparation for the treatment of chronic hepatitis B, it is characterized in that: its effective ingredient comprises following parts by weight of traditional Chinese medicines raw material:

Radix Bupleuri 8-15; Rhizoma Atractylodis Macrocephalae 8-15; Radix Paeoniae Alba 5-12; Flos Carthami 2-8; Radix Salviae Miltiorrhizae 5-12; Herba Hedyotidis Diffusae 15-25; Radix Rehmanniae 5-12; Fructus Lycii 5-12; Radix Aconiti Lateralis Preparata 2-8; Radix Glycyrrhizae Preparata 2-8;

Above raw material through processing, adds the adjuvant or the solution that meet medical standard, makes medically solid preparation or liquid preparation.

2. the Chinese medicine preparation of treatment chronic hepatitis B according to claim 1 is characterized in that: the solid preparation preparation method is as follows: get Radix Salviae Miltiorrhizae, Radix Glycyrrhizae Preparata is crushed into powder, and is standby; Radix Bupleuri, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Flos Carthami, Radix Salviae Miltiorrhizae, Herba Hedyotidis Diffusae, the Radix Rehmanniae, Fructus Lycii and Radix Aconiti Lateralis Preparata are smashed, and per kilogram rises the ethanol extraction twice that volumetric concentration is 50-90% with 5-8, and merge extractive liquid, reclaims ethanol then, obtain the molten dried cream of alcohol, and be standby; Filtration back medicinal residues add water 3-5 by weight and doubly boiled 3-5 hour, it is the water-soluble dried cream of 1.1-1.2 that filtering solution concentration becomes proportion, again with above-mentioned pure molten dried cream and Danshen Root merging, mix homogeneously, add adjuvant, make the solid preparation product, described solid preparation product comprises capsule, granule, tablet; Perhaps add sucrose or Mel, mix homogeneously is made pill;

Described adjuvant is the pharmaceutic adjuvant of various medical standard universals, comprises filler, disintegrating agent, lubricant etc., and filler is starch, dextrin, carboxymethyl starch, calcium hydrogen phosphate, sucrose, Momordia grosvenori aglycone and other pharmaceutic adjuvants; Disintegrating agent is Sodium Tvlose, hydroxypropyl cellulose and pharmaceutic adjuvant with water swelling; Lubricant is the pharmaceutic adjuvant of Polyethylene Glycol, magnesium stearate, Pulvis Talci and tool lubrication.Wherein the weight content of filler, disintegrating agent, lubricant is respectively 30-55%, 3-15%, 0.3%-0.6%.

3. the Chinese medicine preparation of treatment chronic hepatitis B according to claim 1, it is characterized in that: the manufacture method of liquid preparation is as follows: get Radix Salviae Miltiorrhizae, Radix Glycyrrhizae Preparata, Radix Bupleuri, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Flos Carthami, Radix Salviae Miltiorrhizae, Herba Hedyotidis Diffusae, the Radix Rehmanniae, Fructus Lycii and Radix Aconiti Lateralis Preparata and smash, per kilogram rises twice of the ethanol extraction that volumetric concentration is 50-90% with 5-8, merge extractive liquid,, reclaim ethanol then, obtain the molten dried cream of alcohol, standby; Medicinal residues add water 3-5 by weight and doubly boiled 3-5 hour, it is the water-soluble dried cream of 1.1-1.2 that filtering solution concentration becomes proportion, merges with the above-mentioned pure molten dried cream that obtains again, is diluted to suitable concentration, add an amount of sucrose, Momordia grosvenori aglycone and food antiseptics, make the liquid preparation product.

4. the application of the Chinese medicine preparation of treatment chronic hepatitis B as claimed in claim 1 aspect the medicine of the viral chronic hepatitis B of preparation treatment.

5. the application of the medicine of the Chinese medicine preparation of treatment chronic hepatitis B as claimed in claim 1 aspect preparation treatment hepatic fibrosis, liver cirrhosis.