CN102091282B - Medicament for treating chronic gastritis and gastric ulcer - Google Patents
Medicament for treating chronic gastritis and gastric ulcer Download PDFInfo
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Abstract
The invention relates to a medicament for treating chronic gastritis and gastric ulcer, comprising the following crude medicines: Chinese yam, white atractylodes rhizome, tuckahoe, gizzard pepsin, dangshen, amomun fruit, round cardamom, finger citron, hyacinth bletilla, white hyaciath bean, rhizoma corydalis, green orange peel, dried orange peel, rhizoma cyperi, brown malt, charred fructus crataegi, charred medicated leaven, fritillaria cirrhosa, cuttle bone, lotus seed, bitter orange and liquorice. The medicament is prepared by the following steps: frying the Chinese yam, the white hyaciath bean and the lotus seed in a pot until the color is moderate, adding vinegar to the rhizoma corydalis and the rhizoma cyperi, mixing evenly and frying in a pot until the color is moderate, and adding water to all the crude medicines for decocting thrice, combining the decoctions, concentrating, drying and encapsulating. The medicament provided by the invention has the efficacies of strengthening the spleen, benefiting the lung, promoting the production of the body fluid, tonifying the kidney, nourishing the stomach, soothing the liver, removing stagnated food, nourishing the heart and soothing the nerves, and has good curative effects on chronic gastritis and gastric ulcer without toxic side effects proven clinically.
Description
Technical field
The present invention relates to a kind of medicine, specifically relate to a kind of medicine of treating chronic gastritis, gastric ulcer, the invention still further relates to the method for preparing of this medicine.
Background technology
Chronic gastritis is that the non-specific chronic inflammatory disease with gastric mucosa is the chronic gastropathy of main pathological change, and pathological changes can be confined to the part of stomach, the whole stomach that also can permeate, and clinical often have gastric acid minimizing, appetite decline, epigastric discomfort and pain, a dyspepsia etc.Chronic gastritis does not have specificity, generally can show as loss of appetite, epigastrium has glutted feel oppressed sense and pain, feels sick, belch, become thin, diarrhoea etc.The paathogenic factor that causes chronic gastritis has the chronic lesion in acute gastritis protracted course of disease, bacterial infection, medicine irritation, improper diet, nasopharynx oral cavity, achlorhydria etc.
Gastric ulcer is a kind of common chronic systemic disease; Be divided into gastric ulcer and duodenal ulcer; Be called peptic ulcer again, why it is referred to as peptic ulcer, is because think that previously gastric ulcer and duodenal ulcer are because gastric acid and pepsin are formed to the mucosa autodigestion; In fact gastric acid and pepsin are the one of the main reasons of ulcer, also have other reasons can form Peptic Ulcers.Because the cause of disease and the clinical symptoms of gastric ulcer and duodenal ulcer have many similarities, it is gastric ulcer or duodenal ulcer that the doctor is difficult to differentiation sometimes, so often is diagnosed as peptic ulcer, or stomach, duodenal ulcer.If the clear and definite ulcer of ability is at stomach or duodenum, but that is gastric ulcer or duodenal ulcer with regard to direct diagnostic value.Ulcer is normal rounded or oval, and diameter is generally less than 2.5 centimetres, reaches muscular layer of mucosa deeply, and neat in edge when ulcer further develops, can be involved flesh layer or serous coat, even caused perforation.When wearing out blood vessel, can cause bleeding profusely.The clinical manifestation of chronic gastritis and peptic ulcer is lack of specific sometimes.Such as all having stomachache, belch, abdominal distention, inappetence, feeling sick, vomit.
Gastropine, spasmolytic treatment chronic gastritis are used to alleviate spasmic pain, but can not take for a long time, and medicines such as dexamethasone, meticorten have stimulation to gastric mucosa, can increase the weight of the state of an illness of gastric ulcer, should avoid the use of as far as possible.
Summary of the invention
The purpose of this invention is to provide a kind of medicine that can treat chronic gastritis, gastric ulcer, and can treating both the principal and secondary aspects of a disease, have no side effect.
Medicine of the present invention is to be the medicament that crude drug prepares with following parts by weight of traditional Chinese medicines:
Rhizoma Dioscoreae 10-30 Rhizoma Atractylodis Macrocephalaes 6-15
Poria 10-20 Endothelium Corneum Gigeriae Galli 10-15
Radix Codonopsis 10-30 Fructus Amomis 6-8
Fructus Amomi Rotundus 6-8 Fructus Citri Sarcodactylis 6-12
The Pseudobulbus Bletillae (Rhizoma Bletillae) 6-12 Semen Lablab Albums 10-15
Rhizoma Corydalis 10-15 Pericarpium Citri Reticulatae Virides 10-15
Pericarpium Citri Reticulatae 10-15 Rhizoma Cyperis 10-20
Fructus Hordei Germinatus (parched to brown) 10-20 Fructus Crataegi (parched to brown)s 10-20
Massa Medicata Fermentata (parched to brown) 10-20 Bulbus Fritillariae Cirrhosaes 10-12
Os Sepiae 10-30 Semen Nelumbinis 10-15
Fructus Aurantii 10-15 Radix Glycyrrhizaes 3-6.
Further, medicine of the present invention is to be the medicament that crude drug prepares with following parts by weight of traditional Chinese medicines:
Rhizoma Dioscoreae 10-20 Rhizoma Atractylodis Macrocephalaes 6-10
Poria 10-20 Endothelium Corneum Gigeriae Galli 10-15
Radix Codonopsis 10-20 Fructus Amomis 6-8
Fructus Amomi Rotundus 6-8 Fructus Citri Sarcodactylis 6-10
The Pseudobulbus Bletillae (Rhizoma Bletillae) 6-10 Semen Lablab Albums 10-12
Rhizoma Corydalis 10-12 Pericarpium Citri Reticulatae Virides 10-12
Pericarpium Citri Reticulatae 10-12 Rhizoma Cyperis 10-15
Fructus Hordei Germinatus (parched to brown) 10-20 Fructus Crataegi (parched to brown)s 10-20
Massa Medicata Fermentata (parched to brown) 10-20 Bulbus Fritillariae Cirrhosaes 10-12
Os Sepiae 10-20 Semen Nelumbinis 10-12
Fructus Aurantii 10-12 Radix Glycyrrhizaes 3-6.
Said medicine can be made any peroral dosage form such as tablet on the pharmaceutics, pill, powder, capsule etc., the preferred capsule of the present invention.
With the concrete method for preparing of medication preparation capsule of the present invention be:
A) get Rhizoma Dioscoreae, Semen Nelumbinis go into pot fry to little yellow take out subsequent use;
B) Semen Lablab Album being gone into pot fries to yellow taking-up subsequent use;
C) mixing when putting into pot and frying to little yellow with little fire Rhizoma Corydalis thoroughly taking-up with vinegar dries subsequent use;
D) get clean Rhizoma Cyperi grain, mix thoroughly with vinegar, fry to little yellow in 12 hours postposition pots, taking-up is dried subsequent use;
Medicine and all the other ten seven flavor medicine things that e) will pass through the process of preparing Chinese medicine add 2 times of decoctings and boil, and decoct each 0.5h 3 times; Filter the back and mix filtrating three times; Be condensed into the thick paste of 60 ℃ of relative densities 1.20～1.24, obtain medicine activity component after the drying and crushing, be mixed and made into capsule with starch.
The traditional Chinese medical science thinks that the principal element that causes chronic gastritis, gastric ulcer is an eating and drinking without temperance, disorder of emotion, weakness of the spleen and stomach.In the prescription of the present invention, Rhizoma Dioscoreae spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, the kidney invigorating arresting seminal emission; Rhizoma Atractylodis Macrocephalae invigorating the spleen and benefiting QI, the dampness diuretic; The Poria promoting diuresis to eliminate damp pathogen, the spleen invigorating mind calming; The Endothelium Corneum Gigeriae Galli promoting digestion and invigorating the stomach, arresting seminal emission; The Radix Codonopsis invigorating the spleen and replenishing QI, the spleen invigorating lung benefiting; Fructus Amomi mainly acts on stomach, kidney and the spleen of human body, can the circulation of qi promoting seasoning, and stomach function regulating is amusing; The Fructus Amomi Rotundus removing dampness, circulation of qi promoting, warming middle-JIAO, preventing or arresting vomiting; Fructus Citri Sarcodactylis goes into liver, spleen, stomach three warps, and activating QI to eliminate phlegm, preventing or arresting vomiting relieving distension, the liver soothing and the spleen invigorating, the more kinds of medicinal functions of stomach function regulating are arranged; Pseudobulbus Bletillae (Rhizoma Bletillae) astringing to arrest bleeding, detumescence and promoting granulation; The Semen Lablab Album invigorating the spleen for eliminating dampness and in relieve summer heat; Rhizoma Corydalis is warm in nature, and acrid in the mouth is bitter, goes into the heart, spleen, liver, lung, is the quality goods of blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, is world-famous for the effect of pain relieving especially; The soothing the liver dispelling the stagnated QI of Pericarpium Citri Reticulatae Viride, removing food stagnancyization stagnate; Appetizing in Pericarpium Citri Reticulatae regulating QI and lowering the adverseness, the accent, drying dampness to eliminate phlegm; The Rhizoma Cyperi resolving depression of regulating the flow of vital energy, menstruction regulating and pain relieving; Fructus Hordei Germinatus (parched to brown) has invigorating the spleen and regulating the stomach, the stagnant merit of soothing liver-QIization; Fructus Crataegi (parched to brown) spleen benefiting and stimulating the appetite, promoting digestion and removing stagnation, circulation of qi promoting are loose and are become silted up; Massa Medicata Fermentata (parched to brown) strengthening the spleen to promote digestion, the removing dampness of inducing sweat, kind rapid digestion of food food stagnation stagnates; The Bulbus Fritillariae Cirrhosae clearing heat and moistening lung, preventing phlegm from forming and stopping coughing; The Os Sepiae astringing to arrest bleeding, treating spontaneous emission and leukorrhagia, relieving gastric hyperacidity to alleviate stomachache, removing dampness is held back skin ulcer; Semen Nelumbinis clear away heart-fire and are amusing, spleen reinforcing antidiarrheal, and tranquilizing by nourishing the heart makes eye bright, invigorating middle warmer is reposed, antidiarrheal controlling nocturnal emission with astringent drugs, kidney tonifying relieving leukorrhea by astringents, nourishing vigour; The Fructus Aurantii regulating the flow of QI to ease the stomach, the stagnant relieving distension of row; The Radix Glycyrrhizae invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.All medicines share can the spleen invigorating lung benefiting, the lung benefiting that promotes the production of body fluid, tonifying kidney and nourishing stomach, soothing liver-QIization stagnate, tranquilizing by nourishing the heart.
For safety and the curative effect that guarantees medicine of the present invention, use medicine capsule of the present invention that treatment chronic gastritis, gastric ulcer have been carried out observation of curative effect clinically.
One, to treating the observation of curative effect of chronic gastritis
1, patient's situation
92 routine chronic gastritis patients are divided into treatment group and matched group at random, and 58 examples are organized in treatment,
Man's 27 examples, women 31 examples, 18-58 years old ages, 37 years old mean age, the course of disease 2 months-8 years; Matched group 34 examples, male 19 examples, women 15 examples; Age is 20-56 years old, 35.5 years old mean age, the course of disease 2 months-7 years; Selected patient all gets rid of gestation or women breast-feeding their children; Allergic constitution reaches this medicine allergy sufferers, is associated with serious primary disease such as cardiovascular, cerebrovascular, liver, kidney and hemopoietic system, the psychotic.
2, diagnostic criteria
" new Chinese medicine clinical guidance principle " gastroscope diagnostic criteria with reference to Ministry of Public Health promulgation in 1993: mucus increases, and attached to difficult drop-off on the mucosa, stigma lamellar or wire are rubescent, edema, and rotten to the corn, pleat face mucosal abrasion often have white fur.
3, Therapeutic Method
Matched group oral gentamicin sheet, each 2, every day 3 times; Treatment group oral capsule, 1 time 2, every day 3 times, two groups of treatment times all were decided to be for 5 weeks, treatment finishes back check gastroscope statistics curative effect.
4, curative effect determinate standard
" the new Chinese medicine clinical guidance principle " of Ministry of Public Health promulgation in 1993
Recovery from illness: symptom, sign disappear, and chronic inflammatory disease reaches slightly under the gastroscope, and bile reflux disappears;
Produce effects: symptom disappears basically, and the chronic inflammatory disease degree takes a turn for the better under the gastroscope, and bile reflux reduces more than 2/3;
Effectively: doing well,improving, the mucosa infection scope is dwindled more than 1/2 under the gastroscope, and the chronic inflammatory disease degree alleviates, and bile reflux reduces more than 1/2;
Invalid: as not reach effective standard or deterioration person on the contrary.
5, therapeutic outcome
Treatment is organized among the 58 routine gastric ulcer patients and is fully recovered 43, cure rate 74%, produce effects 7, produce effects
Rate 12% takes a turn for the better 5, and improvement rate 9% is invalid 3, inefficiency 5%.Fully recover 17 among the matched group 34 routine chronic gastritis patients, cure rate 50%, produce effects 6, obvious effective rate 18% takes a turn for the better 4, and improvement rate 12% is invalid 7, and inefficiency 20%, individual patients are taken epigastric discomfort behind the gentamycin.
Two, to treating the observation of curative effect of gastric ulcer
1, patient's situation
88 routine gastric ulcer patients are divided into treatment group and matched group at random, and 56 examples are organized in treatment, male 36 examples, women 20 examples, 18-60 years old ages, 38 years old mean age, the course of disease 2 months-8 years.Matched group 32 examples, male 21 examples, women 11 examples, the age is 21-58 years old, 36.2 years old mean age, the course of disease 1 month-7 years.
2, diagnostic criteria
With reference to " the medicine for digestive system clinical research guideline " of Ministry of Public Health promulgation in 1993, syndrome of heat in the stomach: burning pain in the epigastrium, mouthful happiness is thirsty, desire for cold drinks, acid regurgitation.Gingival swelling and pain, dry stool yellowish urine, red tongue with yellow fur.Syndrome of cold in the stomach: stomachache with cool feeling, the pain gesture is acute, cold reviewing gently, the vomiting clear water, tongue is thick in vain.The blood stasis gastric abscess: gastralgia such as acupuncture, fix and do not move tenderness, purplish tongue.The dyspepsia card: gastral cavilty distension pain, acid regurgitation, sour is smelly dirty under rushing down, and thick fur is turbid.
3, Therapeutic Method
Matched group is used ranitidine, 1 150mg, every day 2 times.Oral capsule of the present invention is organized in treatment, 1 time 2, every day 3 times, two groups of treatment times all were decided to be for 8 weeks, treatment finishes back check gastroscope statistics curative effect.
4, curative effect determinate standard
" the medicine for digestive system clinical research guideline " of Ministry of Public Health promulgation in 1993
Recovery from illness: transference cure, ulcer healing of focus under the gastroscope, it is normal that the pathological changes mucosa recovers;
Produce effects: symptom disappears basically, and the ulcer focus heals basically under the gastroscope, and the pathological changes mucous membrane tissue still has mild inflammation;
Take a turn for the better: the primary and secondary symptom partly disappears, healing of focus >=50%;
Invalid: the primary and secondary symptom is improved entirely, ulcer healing of focus≤50%.
5, therapeutic outcome
Fully recover 18 among the matched group 32 routine gastric ulcer patients, cure rate 56%, produce effects 5, obvious effective rate 16% takes a turn for the better 4, and improvement rate 12% is invalid 5, inefficiency 16%.Treatment is organized among the 56 routine gastric ulcer patients and is fully recovered 42, cure rate 75%, and produce effects 7, obvious effective rate 12% takes a turn for the better 5, and improvement rate 9% is invalid 2, inefficiency 4%.
The specific embodiment
Embodiment 1
Get Rhizoma Dioscoreae 1kg, the Rhizoma Atractylodis Macrocephalae 1.5 kg, Poria 1 kg, Endothelium Corneum Gigeriae Galli 1.5 kg, Radix Codonopsis 3 kg, Fructus Amomi 0.6 kg; Fructus Amomi Rotundus 0.7 kg, Fructus Citri Sarcodactylis 1 kg, the Pseudobulbus Bletillae (Rhizoma Bletillae) 0.6 kg, Semen Lablab Album 1.5 kg, Rhizoma Corydalis 1 kg, Pericarpium Citri Reticulatae Viride 1.2 kg; Pericarpium Citri Reticulatae 1.5 kg, Rhizoma Cyperi 2 kg, Fructus Hordei Germinatus (parched to brown) 1 kg, Fructus Crataegi (parched to brown) 1 kg, Massa Medicata Fermentata (parched to brown) 1 kg; Bulbus Fritillariae Cirrhosae 1.2 kg, Os Sepiae 2 kg, Semen Nelumbinis 1.5 kg, Fructus Aurantii 1 kg, Radix Glycyrrhizae 0.6 kg;
A) Rhizoma Dioscoreae, Semen Nelumbinis being gone into pot fries to little yellow taking-up subsequent use;
B) Semen Lablab Album being gone into pot fries to yellow taking-up subsequent use;
C) mixing when putting into pot and frying to little yellow with little fire Rhizoma Corydalis thoroughly taking-up with vinegar dries subsequent use;
D) get clean Rhizoma Cyperi grain, mix thoroughly with vinegar, fry to little yellow in 12 hours postposition pots, taking-up is dried subsequent use;
Medicine and all the other ten seven flavor medicine things that e will pass through the process of preparing Chinese medicine add 2 times of decoctings and boil, and decoct each 0.5h 3 times; Filter the back and mix filtrating three times; Be condensed into the thick paste of 60 ℃ of relative densities 1.20～1.24, obtain medicine activity component after the drying and crushing, add 0.3kg starch and process capsule.
Embodiment 2
Get Rhizoma Dioscoreae 2kg, the Rhizoma Atractylodis Macrocephalae 1.5 kg, Poria 4 kg, Endothelium Corneum Gigeriae Galli 2 kg, Radix Codonopsis 3 kg, Fructus Amomi 2 kg; Fructus Amomi Rotundus 1.8kg, Fructus Citri Sarcodactylis 1.5kg, Pseudobulbus Bletillae (Rhizoma Bletillae) 2kg, Semen Lablab Album 2kg, Rhizoma Corydalis 2.2kg, Pericarpium Citri Reticulatae Viride 2kg; Pericarpium Citri Reticulatae 2.4 kg, Rhizoma Cyperi 3kg, Fructus Hordei Germinatus (parched to brown) 2 kg, Fructus Crataegi (parched to brown) 2kg, Massa Medicata Fermentata (parched to brown) 2kg; Bulbus Fritillariae Cirrhosae 2.2 kg, Os Sepiae 4 kg, Semen Nelumbinis 2kg, Fructus Aurantii 2kg, Radix Glycyrrhizae 1 kg;
A) Rhizoma Dioscoreae, Semen Nelumbinis being gone into pot fries to little yellow taking-up subsequent use;
B) Semen Lablab Album being gone into pot fries to yellow taking-up subsequent use;
C) mixing when putting into pot and frying to little yellow with little fire Rhizoma Corydalis thoroughly taking-up with vinegar dries subsequent use;
D) get clean Rhizoma Cyperi grain, mix thoroughly with vinegar, fry to little yellow in 12 hours postposition pots, taking-up is dried subsequent use;
Medicine and all the other ten seven flavor medicine things that e) will pass through the process of preparing Chinese medicine add 2 times of decoctings and boil, and decoct each 0.5h 3 times; Filter the back and mix filtrating three times; Be condensed into the thick paste of 60 ℃ of relative densities 1.20～1.24, obtain medicine activity component after the drying and crushing, add 0.5kg starch and process capsule.
Claims (4)
1. medicine of treating chronic gastritis, gastric ulcer is characterized in that by following parts by weight of traditional Chinese medicines be the medicament that crude drug prepares:
Rhizoma Dioscoreae 10-30 Rhizoma Atractylodis Macrocephalaes 6-15
Poria 10-20 Endothelium Corneum Gigeriae Galli 10-15
Radix Codonopsis 10-30 Fructus Amomis 6-8
Fructus Amomi Rotundus 6-8 Fructus Citri Sarcodactylis 6-12
The Pseudobulbus Bletillae (Rhizoma Bletillae) 6-12 Semen Lablab Albums 10-15
Rhizoma Corydalis 10-15 Pericarpium Citri Reticulatae Virides 10-15
Pericarpium Citri Reticulatae 10-15 Rhizoma Cyperis 10-20
Fructus Hordei Germinatus (parched to brown) 10-20 Fructus Crataegi (parched to brown)s 10-20
Massa Medicata Fermentata (parched to brown) 10-20 Bulbus Fritillariae Cirrhosaes 10-12
Os Sepiae 10-30 Semen Nelumbinis 10-15
Fructus Aurantii 10-15 Radix Glycyrrhizaes 3-6.
2. the medicine of treatment chronic gastritis according to claim 1, gastric ulcer is characterized in that by following parts by weight of traditional Chinese medicines being that crude drug prepares:
Rhizoma Dioscoreae 10-20 Rhizoma Atractylodis Macrocephalaes 6-10
Poria 10-20 Endothelium Corneum Gigeriae Galli 10-15
Radix Codonopsis 10-20 Fructus Amomis 6-8
Fructus Amomi Rotundus 6-8 Fructus Citri Sarcodactylis 6-10
The Pseudobulbus Bletillae (Rhizoma Bletillae) 6-10 Semen Lablab Albums 10-12
Rhizoma Corydalis 10-12 Pericarpium Citri Reticulatae Virides 10-12
Pericarpium Citri Reticulatae 10-12 Rhizoma Cyperis 10-15
Fructus Hordei Germinatus (parched to brown) 10-20 Fructus Crataegi (parched to brown)s 10-20
Massa Medicata Fermentata (parched to brown) 10-20 Bulbus Fritillariae Cirrhosaes 10-12
Os Sepiae 10-20 Semen Nelumbinis 10-12
Fructus Aurantii 10-12 Radix Glycyrrhizaes 3-6.
3. the medicine of treatment chronic gastritis according to claim 1 and 2, gastric ulcer is characterized in that described medicine is processed capsule.
4. the method for preparing of the said treatment chronic gastritis of claim 3, gastric ulcer medicine may further comprise the steps:
A) get Rhizoma Dioscoreae, Semen Nelumbinis go into pot fry to little yellow take out subsequent use;
B) Semen Lablab Album being gone into pot fries to yellow taking-up subsequent use;
C) mixing when putting into pot and frying to little yellow with little fire Rhizoma Corydalis thoroughly taking-up with vinegar dries subsequent use;
D) get clean Rhizoma Cyperi grain, mix thoroughly with vinegar, fry to little yellow in 12 hours postposition pots, taking-up is dried subsequent use;
E) said process of preparing Chinese medicine medicine and all the other ten seven flavor medicine things are added 2 times of water loggings and do not have decocting for Chinese herbal medicine, decoct 3 times, each 0.5h filters the back and mixes filtrating three times, is condensed into the thick paste of 50 ℃ of relative densities 1.20～1.24, obtains medicine activity component after the drying and crushing.
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| CN102861298B (en) * | 2012-10-18 | 2014-05-21 | 林强 | Traditional Chinese medicine composition for treating chronic gastritis |
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