CN102084863B - Slow-release preparation of slow-release thiadiazine substances - Google Patents

Slow-release preparation of slow-release thiadiazine substances Download PDF

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Publication number
CN102084863B
CN102084863B CN2011100483802A CN201110048380A CN102084863B CN 102084863 B CN102084863 B CN 102084863B CN 2011100483802 A CN2011100483802 A CN 2011100483802A CN 201110048380 A CN201110048380 A CN 201110048380A CN 102084863 B CN102084863 B CN 102084863B
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China
Prior art keywords
slow
release
thiadiazine
substances
parts
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Expired - Fee Related
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CN2011100483802A
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Chinese (zh)
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CN102084863A (en
Inventor
刘鹏
姜淼
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Jiangsu Huaxin Hi Tech Innovation Co ltd
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NINGBO YINZHOU HAOSI RUIPU BIOLOGICAL TECHNOLOGY Co Ltd
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Abstract

The invention provides an agricultural composition, which contains ammonium salt of 2-phenylimino-3-tert butyl-5-phenyl-tetrahydro-1,3,5-thiadiazine-4-ketone, beta-cyclodextrin and microcrystal kaolin mineral serving as a carrier.

Description

A kind of sustained release preparation of diazthines material of slowly-releasing
The present invention relates to a kind of sustained release preparation of diazthines material of slowly-releasing.
Since modern, along with population constantly increases, for the increasing demand increase of grain, therefore, the agricultural chemicals usage amount increases day by day, but the development of agricultural chemicals has brought a large amount of environmental pollutions, and this is the great realistic problem that we have to face.Particularly; In recent years along with development of urbanization; The rural laborer constantly shifts to cities and towns, and the professional number of being engaged in agriculture reduces, by labor savings, and the requirement that the industrial structure problem that agricultural had derived from such as suitably to enlarge during the spreading during spreading strong day by day.Therefore, aspect pesticide developing, need the spreading number of times few, can safety operation, low dose but can keep the medicament of effect for a long time.
But, because the medicament spreading is inhomogeneous etc., often producing superfluous absorption, absorption and the poisoning effect that causes for the plant corpus that should protect, this is a severe impairment to the person of being engaged in agriculture.That is to say, hope that the spreading number of times is few and residual effect property is long, safe, the little technology of plant to the contaminative of environment.
So far, developed the slowly-releasing of the method control agricultural chemicals that uses resin, lyophobic dust and adsorptive support.
Yet these methods have the control effect of rate of release few, are difficult for realizing industrialization.
The prepared composition pesticide of the present invention has solved above-mentioned these existing problems; The composition pesticide that it provided, owing to controlled the rate of release of pesticide activity component from combination carrier, thereby can keep residual effect property for a long time; And can prevent the pollution of the environment, alleviate poisoning.
The diazthines compound is one type of agricultural chemicals commonly used, the present invention relates to the 2-phenylimino-3-tert-butyl group-5-phenyl-tetrahydrochysene-1,3,5-thiadiazine-4-ketone.This compound is a kind of diazthines compound of novel improved, and the present invention at first is made into ammonium salt, process more help behind the ammonium salt its in water dissolving and by plant absorbing.What use is the method for generation ammonium salt commonly used well known in the art, for example mixes transpiring moisture then with concentrated ammonia liquor.
Cyclodextrin is that Villers separated from the starch digestion liquid of bacillus (Bacillus) amylobacter (Bacillus Amylobacter) first in 1891 and obtains; Its correct chemical constitution is just delivered after decades; Clear and definite cyclodextrin be one type by the D2 glucopyranose units through α 21; The cyclic compound that 4 glycosidic bonds join end to end and form, common α 2, β 2 and γ 2 cyclodextrin have 6,7 and 8 glucose units respectively.Because cyclodextrin molecule particular structure, it has some novel character.
The montmorillenite class mineral that use following formula among the present invention are as carrier, and it all belongs to has the phyllosilicate of three-decker mineral.
(Al 5/3Mg 1/3)Si 4O 10(OH) 2·W 1/3·mH 2O
The present invention can also further use other carrier, like mineral matter micro powder, the granular mineral of clay etc., inorganic salts etc.Adjuvant has surfactant, stabilizing agent, physical property modifying agent, bond, colouring agent, incremental agent etc.
The present invention's solid pesticide composition has granula, fine granule and pulvis etc.It adopts conventional breaking method that active component is pulverized, and mixes with cyclodextrin then, adds carrier at last and produces.
Embodiment:
Below illustrate in greater detail the present invention for example.All expressions " parts by weight " or " weight % " of " part " in following examples, " % ".
Embodiment 1
The 30 parts of 2-phenylimino-3-tert-butyl group-5-phenyl-tetrahydrochysenes-1,3 add 60 parts of beta-schardinger dextrin-s in 5-thiadiazine-4-ketone, 570 parts of above-mentioned montmorillenite class mineral add an amount of water and mix after the mixing.The thing that mixes of above gained is placed on granulation in the comminutor that the aperture is the 0.9mm screen cloth is housed, after the shot-like particle drying, thereby whole grain makes the granula that contains active component 3%.
Embodiment 2 (granula)
The 26 parts of 2-phenylimino-3-tert-butyl group-5-phenyl-tetrahydrochysenes-1,3 add 60 parts of beta-schardinger dextrin-s in 5-thiadiazine-4-ketone, 570 parts of above-mentioned montmorillenite class mineral add an amount of water and mix after the mixing.The thing that mixes of above gained is placed on granulation in the comminutor that the aperture is the 0.9mm screen cloth is housed, after the shot-like particle drying, thereby whole grain makes the granula that contains active component 2.4%.
Embodiment 3 (granula)
The 44 parts of 2-phenylimino-3-tert-butyl group-5-phenyl-tetrahydrochysenes-1,3 add 70 parts of beta-schardinger dextrin-s in 5-thiadiazine-4-ketone, 600 parts of above-mentioned montmorillenite class mineral add an amount of water and mix after the mixing.The thing that mixes of above gained is placed on granulation in the comminutor that the aperture is the 0.9mm screen cloth is housed, after the shot-like particle drying, thereby whole grain makes the granula that contains active component 4.7%.
Embodiment 4 (stripping property test in the water)
In beaker, add entry 90ml, in 25 ℃ thermostatic chamber, left standstill 1.Get embodiment 1 prepared product 90mg, evenly be dispensed onto in this beaker.Spreading 1 day, 3, center (depth of water 1cm) water sampling after 9 days and 15 days in the beaker was with each active component of high-speed liquid chromatography analyzer quantitative assay.
According to the amount (μ g) of various active components contained in the granula of amount that is dissolved into each active component in the water (μ g) and spreading or the pulvis, obtain dissolution rate with following formula.
Dissolution rate in the water (%)=(dissolving in the active principle (μ g) in the water)/(in the granula of spreading or the pulvis contained active principle (μ g)) * 100
Embodiment After 1 day After 3 days After 9 days After 15 days After 30 days
Embodiment 1 17.2 34.4 46.7 61.4 72.6
Embodiment 2 18.5 32.5 42.7 59.1 74.4
Embodiment 3 24.1 36.7 48.6 63.2 78.1
Embodiment 4 22.4 33.5 45.4 60.2 78.6
Find that through above-mentioned experiment the sustained release agent that the present invention makes has very good slow release effect.

Claims (1)

1. OneKind of agricultural is used composition, and it contains the 2-phenylimino-3-tert-butyl group-5-phenyl-tetrahydrochysene-1,3, the ammonium salt of 5-thiadiazine-4-ketone, beta cyclodextrin and as the montmorillenite class mineral of carrier.
CN2011100483802A 2011-03-01 2011-03-01 Slow-release preparation of slow-release thiadiazine substances Expired - Fee Related CN102084863B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN2011100483802A CN102084863B (en) 2011-03-01 2011-03-01 Slow-release preparation of slow-release thiadiazine substances

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Application Number Priority Date Filing Date Title
CN2011100483802A CN102084863B (en) 2011-03-01 2011-03-01 Slow-release preparation of slow-release thiadiazine substances

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CN102084863A CN102084863A (en) 2011-06-08
CN102084863B true CN102084863B (en) 2012-03-28

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Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104351176A (en) * 2014-11-11 2015-02-18 济南新起点医药科技有限公司 Allicin controlled release formulation

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61197503A (en) * 1985-02-25 1986-09-01 Nippon Nohyaku Co Ltd Agricultural chemical composition
EP0998200B1 (en) * 1997-07-23 2002-12-18 Basf Aktiengesellschaft Plant protection products in the form of a granulate with controlled release of the active agent
CN101385475A (en) * 2007-12-27 2009-03-18 广东省中药研究所 Slow-release natural insecticide
CN101390513B (en) * 2008-10-17 2011-10-05 中国农业大学 Uniconazole-cyclodextrin clathrate, preparation method and use thereof
CN101946811B (en) * 2010-08-26 2013-07-31 天津绿新低温科技有限公司 Microencapsulated botanical insect-resist agent

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