CN102078265A - Oligosaccharide composition and application in cosmetics - Google Patents
Oligosaccharide composition and application in cosmetics Download PDFInfo
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- CN102078265A CN102078265A CN201010593506XA CN201010593506A CN102078265A CN 102078265 A CN102078265 A CN 102078265A CN 201010593506X A CN201010593506X A CN 201010593506XA CN 201010593506 A CN201010593506 A CN 201010593506A CN 102078265 A CN102078265 A CN 102078265A
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Abstract
The invention discloses an oligosaccharide composition and application in cosmetics. In the oligosaccharide composition, alginate-derived oligosaccharide with the weight-average molecular weight of below 1,000 Da (the polymerization degree of between 2 and 5), chitosan oligosaccharide with the weight-average molecular weight of below 1,000 Da and a proportional mixture of the alginate-derived oligosaccharide and the chitosan oligosaccharide are selected as additives of the cosmetics. The two oligosaccharides have a powerful radiation protection function by combining at a certain concentration, and the combination has a good radiation protection function when used in a product of the cosmetics. The oligosaccharide composition has the characteristic of the good radiation protection function by mixing the alginate-derived oligosaccharide and the chitosan oligosaccharide with the weight-average molecular weight of below 1,000 Da in aqueous solution in a ratio of below 0.1 percent. The product has three defense system functions such as physical radiation defense (barrier), cell membrane structure regulation and intracellular enzymatic and non-enzymatic radiation resisting system regulation, and can promote cells to absorb effectively by regulating lipid channels of a membrane system and enhance anti-radiation tension by acting in an intracellular enzymatic and non-enzymatic anti-radiation system.
Description
The technical field cosmetics
The background technology cosmetics are to smear, to spray or other similar approach, to impose on any position of human body surface (skin, hair, fingernail, lip, oral mucosa etc.), to reach the product of cleaning, elimination bad smell, skin protection, beauty treatment and modification purpose.Anthranilates is the molecule that sees through the active chemical in the sunscreen products, after the skin epidermis absorbs, generates reciprocal action with ultraviolet and makes it be transformed into harmless energy.Found in recent years that the natural biological product had application widely on cosmetics, tea polyphenols (Tea polyphenols) wherein, flavone (Flavonoids), Fructus Vitis viniferae procyanidin (Grape procyanidins), hesperidin (Hesperidin) etc. all have the related basic research report.
Summary of the invention the present invention relates to oligosaccharide is applied to the method for cosmetics manufacturing industry in order to radiation protection.The present invention selects for use weight average molecular weight to be lower than the brown alga oligose of 1000Da (degree of polymerization is at 2-5) and oligochitosan and both mixed things that weight average molecular weight is lower than 1000Da (degree of polymerization is at 2-5) are cosmetics additive.For brown alga oligose, the characteristics of this oligosaccharide are to act on Algin with alginate lyase, lyase (Lyase) can ftracture into two parts by the catalytic substrate molecule, one of them contains two keys, and alginate lyase produces the oligosaccharide aldehydic acid that contains unsaturated double-bond by β-alignic glycosidic bond of elimination reaction cracking and at the non reducing end of product.At C
5On lose symmetry, therefore no matter be that D-mannuronic acid or L-guluronic acid all generate unsaturated derivant, the oligosaccharide of generation, this oligosaccharide has extinction characteristic at 180-300nm, at 230～240nm strong absorption is arranged, and has the efficient absorption action of ultraviolet ray.And for oligochitosan, the weight average molecular weight that is prepared from through chitosanase (Chitosan) degrade chitosan is lower than the oligosaccharide of 1000Da (degree of polymerization is at 2-5).Two kinds of oligosaccharide are made up under certain concentration have powerful radiation protection, the product of using it for cosmetics has good radiation protection.Characteristics of the present invention are to select enzymolysis algin oligosaccharide and the oligochitosan of molecular weight less than 1000Da for use, with＜0.1% mixed, have good radiation resistance in aqueous solution.This product has physics defence radiation (barrier), membrane structure is regulated, regulate with urge to become reconciled non-enzymatic radioprotective system of desmoenzyme, three layers of defense system function, by regulating the lipid passage of film system, can promote cell to absorb effectively, and act on cell interior enzymatic and non-enzymatic regulating system, strengthen radioprotective tension force.The simple covering function that has surmounted the radiation shield agent far away.It is a kind of active anti-rad.
Description of drawings: the range of molecular weight distributions of Fig. 1 brown alga oligose.
The range of molecular weight distributions of Fig. 2 oligochitosan.
The specific embodiment
With a kind of radioprotective frost is example
1, takes by weighing sodium alginate, be made into 1% aqueous solution with distilled water, temperature of reaction kettle is controlled at 30 ℃ to be incubated to solution temperature constant, the unit of activity that adds 500U by every gram substrate, degraded 2 hours, be heated to 100 ℃ of cessation reactions, the oligosaccharide molecular weight range that this degraded obtains is＜1000Da molecular weight detection result such as Fig. 1.
2, take by weighing the chitosan of deacetylation＞85, be made into 1% aqueous solution with distilled water, transfer PH to 4.0 with glacial acetic acid, add chitosanase, temperature of reaction kettle is controlled at 30 ℃ is incubated to solution temperature constantly, add the unit of activity enzyme of 300U by every gram substrate, degraded 3 hours, be heated to 100 ℃ of cessation reactions, the oligosaccharide molecular weight range that this degraded obtains is＜1000Da molecular weight detection result such as Fig. 2.
3, by following formulated oil phase and water, add oligosaccharide to aqueous phase, be mixed with and contain the active cosmetics of radioprotective.Oil phase: cocos nucifera oil (caprylic/capric) ester 8
Jojoba oil 3
Octadecanol 7.5
Hexadccyl palmitate 5
Polydimethylsiloxane (350csks) 10
2-iso-octyl-2 cyano group-3,3-diphenylacrylate ester 5
Vitamin E 2
Glyceryl stearate 3
Water: deionized water 51.5, contain brown alga oligose 0.2%, oligochitosan 0.2%
Glycerol 5
Citric acid is transferred PH to 5.6
Method for making: oil phase component is poured in the container, be stirred and heated to 80～85 ℃, mixing water phase component in another container is stirred and heated to 80～85 ℃.Stir and down water is joined oil phase homogenizing, insulation 10 minutes.Be cooled to 50 ℃, packing.
Claims (4)
1. an oligosaccharide compositions is made up of brown alga oligose and oligochitosan.
2. molecular weight＜the 1000Da of brown alga oligose in the compositions.
3. molecular weight＜the 1000Da of oligochitosan in the compositions.
With brown alga oligose and oligochitosan simultaneously in cosmetics, brown alga oligose is 0.001-1% at the addition of cosmetics, the addition 0.001-1% of oligochitosan.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010593506XA CN102078265A (en) | 2010-12-11 | 2010-12-11 | Oligosaccharide composition and application in cosmetics |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010593506XA CN102078265A (en) | 2010-12-11 | 2010-12-11 | Oligosaccharide composition and application in cosmetics |
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| CN102078265A true CN102078265A (en) | 2011-06-01 |
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| CN201010593506XA Pending CN102078265A (en) | 2010-12-11 | 2010-12-11 | Oligosaccharide composition and application in cosmetics |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104224650A (en) * | 2014-06-05 | 2014-12-24 | 温州医科大学 | Large seaweed extract sunscreen skin care emulsion and preparation method thereof |
| CN105902408A (en) * | 2015-09-25 | 2016-08-31 | 上海百雀羚日用化学有限公司 | Cosmetic composition containing brown algae and red algae essence |
| CN106176319A (en) * | 2016-08-30 | 2016-12-07 | 青岛博智汇力生物科技有限公司 | A kind of Whitening sunscreen cream containing marine oligosaccharide |
| CN112608349A (en) * | 2020-12-02 | 2021-04-06 | 青岛博智汇力生物科技有限公司 | Preparation method of guluronic acid oligosaccharide with antioxidant activity |
| CN115517258A (en) * | 2022-09-15 | 2022-12-27 | 中科荣耀(苏州)生物科技有限公司 | Composition containing brown algae oligosaccharide and chitosan oligosaccharide and preparation method and application thereof |
-
2010
- 2010-12-11 CN CN201010593506XA patent/CN102078265A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104224650A (en) * | 2014-06-05 | 2014-12-24 | 温州医科大学 | Large seaweed extract sunscreen skin care emulsion and preparation method thereof |
| CN104224650B (en) * | 2014-06-05 | 2017-01-11 | 温州医科大学 | Large seaweed extract sunscreen skin care emulsion and preparation method thereof |
| CN105902408A (en) * | 2015-09-25 | 2016-08-31 | 上海百雀羚日用化学有限公司 | Cosmetic composition containing brown algae and red algae essence |
| CN105902408B (en) * | 2015-09-25 | 2019-02-05 | 上海百雀羚生物科技有限公司 | Cosmetic composition containing brown alga and red algae essence |
| CN106176319A (en) * | 2016-08-30 | 2016-12-07 | 青岛博智汇力生物科技有限公司 | A kind of Whitening sunscreen cream containing marine oligosaccharide |
| CN112608349A (en) * | 2020-12-02 | 2021-04-06 | 青岛博智汇力生物科技有限公司 | Preparation method of guluronic acid oligosaccharide with antioxidant activity |
| CN115517258A (en) * | 2022-09-15 | 2022-12-27 | 中科荣耀(苏州)生物科技有限公司 | Composition containing brown algae oligosaccharide and chitosan oligosaccharide and preparation method and application thereof |
| CN115517258B (en) * | 2022-09-15 | 2024-04-05 | 中科荣耀(苏州)生物科技有限公司 | Composition containing brown alginate oligosaccharides and chitosan oligosaccharides, and preparation method and application thereof |
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| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20110601 |