CN102068948A - Polymer microsphere with golf ball surface structure and preparation method thereof - Google Patents
Polymer microsphere with golf ball surface structure and preparation method thereof Download PDFInfo
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- CN102068948A CN102068948A CN2010105573020A CN201010557302A CN102068948A CN 102068948 A CN102068948 A CN 102068948A CN 2010105573020 A CN2010105573020 A CN 2010105573020A CN 201010557302 A CN201010557302 A CN 201010557302A CN 102068948 A CN102068948 A CN 102068948A
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Abstract
The invention discloses a polymer microsphere with a golf ball surface structure and a preparation method thereof. The preparation method comprises the following steps of: performing phase transition on solvents such as lactic acid-glycollic acid polymer, polyvinyl alcohol and the like serving as raw materials; preparing oil solution and aqueous solution; mixing the solution so as to obtain oil in water liquid; volatilizing; and the like. The prepared polymer microsphere with the golf ball surface structure has a novel structure, has a hollow core porous shell structure, is provided with recesses which are similar to the surface of a golf ball on the surface, has high biocompatibility, can be applied to a medicament carrier, can be applied to an interaction system between active sites in a biological imaging system and a simulation biological system, and has wide application prospects in fields such as biology, medical science and the like.
Description
Technical field
The present invention relates to polymer composite of ad hoc structure and preparation method thereof, more specifically, is a kind of polymer microsphere with golf surface texture and preparation method thereof.
Background technology
The Biodegradable Polymers microballoon is with a wide range of applications at biomedical sector, the controlled release system in medicine carrying for example, batching in the personal-care supplies and as medical imaging agent etc., in the middle of these are used, the internal structure of Nano/micron size, parameter such as surface topography and Size Distribution is all very important, these parameter appreciable impact medicine carrying efficient, the activity of release dynamics and packed thing, therefore, these parameters of accuracy controlling seem extremely important, during especially as active agent carrier, overriding concern be the nucleocapsid structure that how to obtain and control microballoon.At present, surface topography characteristic how to regulate and control thin polymer film makes its better application become the focus of extensive concern at biomedical sector.If microballoon not only has the surface while of dimple shape depression but also has inner complicated loose structure, so not only increased the surface area of release, more loading site also is provided, aspect the interaction of strengthening biomolecule imaging system, multiple drug dose system and simulation living things system potential application prospect must have been arranged.
According to present report, there are two kinds of methods to prepare the polymer microsphere of above-mentioned shape: 1, seed propagate polymerization method or emulsion polymerization (seeded dispersion or emulsion polymerization); 2, utilize little micelle stable emulsion method (for example pickering emulsion polymerization).But the former is not suitable for aliphatic polyester and biodegradation material, and the latter is the internal structure of uncontrollable particulate then.Obtain the porous pattern of existing inside, the surperficial simultaneously method that has the microballoon of sunk structure again waits research.
Summary of the invention
Polymer microsphere with golf surface texture that provides a kind of novel structure, good biocompatibility and preparation method thereof is provided the object of the invention.
The present invention realizes by following technological means: at resistance features of smaller when mobile in liquid of the polymer microsphere with golf surface texture, adopting lactic acid-ethanol copolymer and polyvinyl alcohol equal solvent is raw material, by changing, prepare steps such as oil phase liquid and water liquid, preparation oil-in-water liquid, solvent evaporates mutually, a kind of novel structure is provided and has the polymer microsphere with golf surface texture of good biocompatibility, technology is simple, easy operating.
Preparation of the present invention has the method for the polymer microsphere of golf surface texture, comprises the steps:
(1) preparation changes solution mutually: with molecular weight is that 3～1,000,000 lactic acid-ethanol copolymer is dissolved in the organic facies transition material, wherein, the mass percent of described lactic acid-ethanol copolymer is 50～75%, described organic facies transition material is selected from a kind of in dichloropentane, a chloropentane and the pentane, is changed solution mutually;
(2) preparation oil phase liquid: with above-mentioned solution and the oil phase solvent of changing mutually, wherein, the described mass percent that changes solution mutually is 5～15%, and described oil phase solvent is selected from a kind of in chloroform, the carrene, obtains oil phase liquid after mixing;
(3) preparation water liquid: with molecular weight is that 1～100,000 polyvinyl alcohol is dissolved in the aqueous phase solvent, wherein, the mass percent of polyvinyl alcohol is 0.5～1.5%, and described water tank capacity is selected from a kind of in water, ethanol, the dimethyl formamide, obtains water liquid after mixing;
(4) preparation oil-in-water liquid: above-mentioned oil phase liquid is added in the water liquid under 200～1000 rev/mins rotating speed, obtain oil-in-water liquid;
(5) preparation microballoon: above-mentioned oil-in-water liquid was placed 3～5 hours at normal temperatures, treated to obtain having after the oil phase solvent evaporates fully the polymer microsphere of golf surface texture.
Utilize the polymer microsphere with golf surface texture of method for preparing, diameter is 50～500 μ m, and the surface apertures size is 5～50 μ m.
The polymer microsphere with golf surface texture according to the present invention's preparation has inner adjustable hollow-core construction, the surface has similar golf depression in the surface simultaneously, and can effectively regulate and control size and the external pores rate and the microsphere surface pattern of boring structure by the amount of regulation and control organic facies transition material, can be used for the biomedical sectors such as system with interaction between the avtive spot in pharmaceutical carrier, bio-imaging system, the simulation living things system; Simple and reliable process can be controlled the surface topography of polymer microsphere, can also regulate and control microballoon internal voids structure, need not adopt high-pressure installation, easy operating and realize industrialization.
The specific embodiment
Below describe preferred implementation of the present invention, but be not in order to limit the present invention.
Embodiment 1:
Be prepared as follows polymer microsphere with golf surface texture:
(1) preparation changes solution mutually: with molecular weight be 500,000 segment than being L: G=65: 35 lactic acid-ethanol copolymer is dissolved in the organic facies transition material, wherein, the mass percent of described lactic acid-ethanol copolymer and organic facies transition material is 70%, described organic facies transition material is a dichloropentane, is changed solution mutually;
(2) preparation oil phase liquid: with above-mentioned solution and the oil phase solvent of changing mutually, wherein, the described mass percent that changes solution mutually is 10%, and described oil phase solvent is a carrene, obtains oil phase liquid after mixing;
(3) preparation water liquid: with molecular weight is that 30,000 polyvinyl alcohol is dissolved in the water, and wherein, the mass percent of polyvinyl alcohol is 1%, obtains water liquid after mixing;
(4) preparation oil-in-water liquid: above-mentioned oil phase liquid is added in the water liquid under 300 rev/mins magnetic agitation with syringe (21G), obtain oil-in-water liquid;
(5) preparation microballoon: above-mentioned oil-in-water liquid was placed 3 hours at normal temperatures, treated that obtaining diameter after carrene volatilizees fully is 200 μ m, the surface apertures size is the polymer microsphere with golf surface texture of 10 μ m.
Facts have proved, utilize the polymer microsphere with golf surface texture of method preparation of the present invention, has inner adjustable hollow-core construction, the surface has similar golf depression in the surface simultaneously, the compact texture that depressed part is can prevent that the prominent of inner embedding thing release, novel structure and have excellent biological compatibility, and preparation technology is simple and reliable, need not adopt high-pressure installation, easy operating and realization industrialization.
Claims (2)
1. the preparation method with polymer microsphere of golf surface texture is characterized in that, comprises the steps:
(1) preparation changes solution mutually: with molecular weight is that 3～1,000,000 lactic acid-ethanol copolymer is dissolved in the organic facies transition material, wherein, the mass percent of described lactic acid-ethanol copolymer is 50～70%, described organic facies transition material is selected from a kind of in dichloropentane, a chloropentane and the pentane, is changed solution mutually;
(2) preparation oil phase liquid: with above-mentioned solution and the oil phase solvent of changing mutually, wherein, the described mass percent that changes solution mutually is 5～15%, and described oil phase solvent is selected from a kind of in chloroform, the carrene, obtains oil phase liquid after mixing;
(3) preparation water liquid: with molecular weight is that 1～100,000 polyvinyl alcohol is dissolved in the aqueous phase solvent, wherein, the mass percent of polyvinyl alcohol is 0.5～1.5%, and described water tank capacity is selected from a kind of in water, ethanol, the dimethyl formamide, obtains water liquid after mixing;
(4) preparation oil-in-water liquid: above-mentioned oil phase liquid is added in the water liquid under 200～1000 rev/mins rotating speed, obtain oil-in-water liquid;
(5) preparation microballoon: above-mentioned oil-in-water liquid was placed 3～5 hours at normal temperatures, treated to obtain having after the oil phase solvent evaporates fully the polymer microsphere of golf surface texture.
2. the polymer microsphere with golf surface texture according to the described method preparation of claim 1 is characterized in that diameter is 50～500 μ m, and the surface apertures size is 5～50 μ m.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010105573020A CN102068948A (en) | 2010-11-19 | 2010-11-19 | Polymer microsphere with golf ball surface structure and preparation method thereof |
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| CN2010105573020A CN102068948A (en) | 2010-11-19 | 2010-11-19 | Polymer microsphere with golf ball surface structure and preparation method thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103284290A (en) * | 2013-05-24 | 2013-09-11 | 肇庆巨元生化有限公司 | Good microencapsulation method for carotenoid |
| CN103315370A (en) * | 2013-05-24 | 2013-09-25 | 肇庆巨元生化有限公司 | A stable method for microencapsulating carotenoid |
| CN103613718A (en) * | 2013-10-23 | 2014-03-05 | 江南大学 | Polyvinyl alcohol macromonomer based method for preparing functional microsphere |
| CN108136068A (en) * | 2015-10-12 | 2018-06-08 | 医药研究产品有限公司 | The manufacturing method of hollow porous micro sphere |
| CN112980043A (en) * | 2021-03-08 | 2021-06-18 | 浙江大学 | Homogeneous core-shell structure porous chitosan microsphere and preparation method and application thereof |
-
2010
- 2010-11-19 CN CN2010105573020A patent/CN102068948A/en active Pending
Non-Patent Citations (1)
| Title |
|---|
| MI RI KIM ET AL: "Golf ball-shaped PLGA microparticles with internal pores fabricated by simple O/W emulsion", 《CHEMCOMM》 * |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103284290A (en) * | 2013-05-24 | 2013-09-11 | 肇庆巨元生化有限公司 | Good microencapsulation method for carotenoid |
| CN103315370A (en) * | 2013-05-24 | 2013-09-25 | 肇庆巨元生化有限公司 | A stable method for microencapsulating carotenoid |
| CN103613718A (en) * | 2013-10-23 | 2014-03-05 | 江南大学 | Polyvinyl alcohol macromonomer based method for preparing functional microsphere |
| CN103613718B (en) * | 2013-10-23 | 2015-12-30 | 江南大学 | A kind of method preparing functional microsphere based on polyvinyl alcohol macromonomer |
| CN108136068A (en) * | 2015-10-12 | 2018-06-08 | 医药研究产品有限公司 | The manufacturing method of hollow porous micro sphere |
| CN108136068B (en) * | 2015-10-12 | 2021-09-21 | 医药研究产品有限公司 | Method for producing hollow porous microspheres |
| CN112980043A (en) * | 2021-03-08 | 2021-06-18 | 浙江大学 | Homogeneous core-shell structure porous chitosan microsphere and preparation method and application thereof |
| CN112980043B (en) * | 2021-03-08 | 2022-02-01 | 浙江大学 | Homogeneous core-shell structure porous chitosan microsphere and preparation method and application thereof |
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Application publication date: 20110525 |