CN102058715A

CN102058715A - Chinese medicine preparation for treating chronic prostatitis and preparation method thereof

Info

Publication number: CN102058715A
Application number: CN 201010595283
Authority: CN
Inventors: 郭瑶; 陈玲; 崔守凤
Original assignee: Individual
Current assignee: Individual
Priority date: 2010-12-20
Filing date: 2010-12-20
Publication date: 2011-05-18
Anticipated expiration: 2030-12-20
Also published as: CN102058715B

Abstract

The invention relates to a Chinese medicine preparation for treating chronic prostatitis, which is characterized by comprising the following raw medicines: radix rehmanniae preparata, cynomorium songaricum rupr, radix astragali, rhizoma corydalis, herba epimedii, dodder, herba ecliptae, schisandra chinensis, hedyotis diffusa, safflower, radix polygoni multiflori preparata, fructus ligustri lucidi, salvia miltiorrhiza, radix paeoniae alba, myrrh, prunella vulgaris, fructus cnidii, herba patriniae, scutellaria baicalensis georgi, angelica and cortex moutan. In the invention, Chinese herbal medicines for promoting blood circulation and removing blood stasis are adopted, the permeability of capillaries can be improved, inflammation reaction can be alleviated, the extinction and the absorption of inflammation focus can be promoted, the metabolism of connective tissues can be improved, the transformation and the absorption of hyperplastic lesions can be promoted, and atrophic connective tissues can recover. When the Chinese medicine preparation for treating chronic prostatitis is applied through rectums, the medicines can be absorbed in the rectums, enema or suppository enables the medicines to be absorbed through rectum mucosa to directly reach affected parts; and the Chinese medicine preparation can reach higher consistency in diseased prostate and has the advantages of ideal treating effect, low price and simple, convenient and practical preparation method.

Description

A kind of Chinese medicine preparation for the treatment of chronic prostatitis and preparation method thereof

Technical field

The present invention relates to contain medicinal preparation that derives from plant, animal or mineral component and preparation method thereof, particularly a kind of Chinese medicine preparation for the treatment of chronic prostatitis and preparation method thereof.

Background technology

The criteria for classification that nineteen ninety-five December NIH (N IH) proposes is divided into I, II, III (comprising IIIA and IIIB), IV class with prostatitis.Wherein the IIIA class is struvite chronic basin pain syndrome, clinically comparatively sees more, mainly shows as the perineal position discomfort, penis, testis, lower abdomen pain, frequent micturition, urgent micturition, dysurea, the syndrome of multiple symptoms such as urine retention sense and sexual hypofunction.Its cause of disease and pathogenesis are still unclear at present, most scholars think increase with pathogenic infection, urethral resistance, autoimmune response, chemical factor and neuromuscular factor etc. be relevant, its therapeutic effect is also unsatisfactory.Be limited to scientific development level at that time, the Chinese medicine of being born in before more than 2,000 year there is no prostatitic record, according to clinical symptoms and sign, generally it is included into categories such as " stranguria ", " smart turbid ", " excessive in vain ".The traditional Chinese medical science is thought its cause of disease one for having a liking for food cigarette, wine, pungent, delicious food savoury, impairing the spleen and stomach, make give birth to damp and hot, the multiple abscess part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels; Two is intemperate sexual intercourse, directly contamination, and damp and hot poison is evil to drive in the wrong direction, and stations the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels; Three is influences such as society and environmental factors, medium stimulation, and libido can not get normal catharsis, frequent masturbation, and intemperate sexual intercourse bears essence not let out, and it is congested repeatedly to cause prostate, and the smart chamber of retention of corruptive essence accumulates wine poison of a specified duration, hinders in meridians; Or feelings will is not smooth, depressed rage impairing the liver, and irritability is lost in catharsis, and hematogenous blockage and cause coagulation of QI-blood then for a long time, coagulation of QI-blood can increase the weight of again that damp and hot poison is evil to form both reciprocal causations.The symptom of chronic prostatitis varies with each individual, and mainly is divided into following two kinds: a kind of for pain symptom, contain around hypogastric region, lumbosacral region, the anus, position pain such as perineal position and testis, penis; Another kind of be the discomfort of urinating,, urine unable as urine retention, frequent micturition, urgent micturition, urine is droplet white etc.General Symptoms is mainly that anxiety, energy are not concentrated, lassitude, and it is unusual also can be attended by sexual function, as ejaculate too fast, erection is not hard, hyposexuality etc.NIH (NIH) is divided into four types with prostatitis: I, acute bacterial prostatitis, II, chronic bacterial prostatitis, III, chronic nonbacterial prostatitis, IV, the struvite prostatitis of silent.Wherein the III type is divided into two hypotypes according to prostatic fluid (EPS) microscopy, and WBC (leukocyte) 10/HP is above be a type, and the following and pH value of WBC 10/HP is low to be b type, i.e. pain syndrome (CAP/CPPS) at the bottom of chronic nonbacterial prostatitis/basin.

Prostatitis divides acute bacterial, chronic bacillary and non-bacterial etc. dissimilar.Its pathogeny is a bacterial infection; The staphylococcus epidermidis immunoreation; Arthritis, iritis, urethra instrumental examination, catheter are placed, and upper respiratory tract, urinary system infection, sexual function change or eating and drinking without temperance, and susceptible to anger causes retention of damp-heat in the interior frequently, loses smart turbid corruption, causes the body of gland inflammation, abscess.The classical symptom of acute stage is that feel cold heating, fervescence, nausea and vomiting, urine urgency-frequency, dysurea turbid urine, constipation, perineal position and lower back portion distending pain, prostate swells and ache.The clinical manifestation of chronic phase be dizzy dizzy, waist is ached, urine urgency-frequency, urinate endless, urinate the back and discharge mucus, hyposexuality, impotence and premature ejaculation, painful and swollen testis prostatitis disease the symptom complexity is arranged, course of disease delay, obstinate difficult more, characteristics such as easy recurrence.Traditional medicine is used eliminating damp-heat, pyretic toxicity is treating stranguria, and the method multipotency proves effective.Chronic prostatitis is the common disease of adult male, and this disease patient accounts for Urologic Surgery Clinic patient's 8%～25% according to statistics, and the prostatitis prevalence is 2.7%～8.7% among 20～79 years old the male in the Asia.The pathological characteristic of distinctive anatomical structure of prostate and chronic prostatitis makes very difficulty of its treatment.

Chronic prostatitis is male person between twenty and fifty's a commonly encountered diseases, frequently-occurring disease, and the chronic prostatitis prevalence can be up to 35%～37% in the male more than 36 years old.Slow to fall ill clinically, the etiology and pathology complexity, the symptom performance is various, and sign is not true to type, state of an illness delay outbreak repeatedly, prolonged difficulty more is characteristics.The contact of being meant property of acute and chronic prostatitis and infectious urethritis, prostatitis is male genital commonly encountered diseases, pilosity is born in 20 years old-40 years old person between twenty and fifty, the symptom that this disease is common is followed successively by: urethra drips white, soreness of the waist and knees, dribble of urine, lower abdominal distention pain, cloudy urine, dizzy dizziness, insomnia and dreamful sleep, waist sacrum distending pain, testis and spermatic cord distending pain, urethra causalgia, sexual impotence, premature ejaculation etc.Current prostate sickness rate than higher (in the male person between twenty and fifty of 20-45, prostatic sickness rate reaches more than the 25-45%, also reach more than 25% because of suffering from acute and chronic prostatitis prescription on individual diagnosis person in the Urologic Surgery Clinic at home, wherein 35 years old-40 years old sickness rate can be up to 40%), infective pathogen microorganism complexity (antibacterial, virus, mycete, infusorian, mycoplasma, chlamydia, escherichia coli, aerobacteria such as Gram-positive coccus-gold-coloured staphylococci etc.), general water solublity antibacterials are because prostate position is darker, the circulation of body of gland inner blood is not smooth, three layers of adipose membrane of body of gland outer wrapping, even reason such as prostate aseptic inflammation is difficult to penetrate prostate and to prostatitis elimination effect targetedly, faint for the prostate effect, the tradition oral drugs are through stomach, intestinal, liver, gallbladder, absorptions such as kidney consume and the consumption of blood circulation road is difficult in the enough blood drug level of prostatic cohesion, main Therapeutic Method for chronic prostatitis is Drug therapy and naturopathy at present, wherein Drug therapy comprises each antibiotics, the α receptor blocking agent, immunosuppressant and additional zinc and vitamin, route of administration is for for oral administration, injection, rectal perfusion, the anus filling, body of gland injection etc.; Wherein naturopathy comprises that microwave, muscle electric stimulation, hot water hip-bath, massage of prostate, the four cavities conduit pipe administrations of two capsule, direct injection (per rectum or perineum), medicine unidirectional current import.Also comprise the psychotherapy in the present Therapeutic Method, mainly based on psychological counseling.But adopt above-mentioned Therapeutic Method, the patient is comparatively painful, and the treatment persistent period is longer, and effect is not ideal.More than various ways, the damage testicular spermatogenic, it only is auxiliary treatment means, even certain methods complicated operation, and problems such as dangerous in addition, cross infection, the suppository of other rectals, unguentum exist that dosage form is unreasonable, compatibility not science, the relatively poor drawback of treatment.But a large amount of clinical practices shows that above-mentioned Therapeutic Method general effect is not good enough.Prior art studies show that, Chinese medicine is being obtained curative effect preferably aspect the treatment chronic prostatitis, especially improving patient's symptom, improving and to have than remarkable advantages aspect the patients ' life quality, and expense is cheaper, in recent years, more and more receive the concern of this area research worker about the prostatitic medicine of treatment by Chinese herbs and research.

Summary of the invention

Technical problem to be solved by this invention is that needs are a kind of cheap, and toxic and side effects is little, and is evident in efficacy, and the Chinese medicine preparation that can take is for a long time treated patients with chronic prostatitis; The prostatitic medicine of treatment in the prior art mostly is to use injection in antibiotic, the capsula prostatica, and the Western medicine toxic and side effects is strong, and is bigger to the human injury; Chinese medicine decoction is oral, though some curative effects are arranged, curative effect is not good enough, and it is slow to take effect, and the drug manufacture cost is higher, and manufacturing cycle is longer, and the drug absorption rate is low.

For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine preparation for the treatment of chronic prostatitis, the ratio of weight and number of various crude drug is in the described Chinese medicine preparation: 10～20 parts of Radix Rehmanniae Preparata, 10～20 parts of Herba Cynomoriis, 10～20 parts of the Radixs Astragali, 10～20 parts of Rhizoma Corydalis, 10～20 parts of Herba Epimedii, 10～20 parts of Semen Cuscutae, 10～20 parts of Herba Ecliptaes, 10～20 parts of Fructus Schisandrae Chinensis, 10～20 parts of Herba Hedyotidis Diffusaes, 10～20 parts on Flos Carthami, 10～20 parts of Radix Polygoni Multiflori Preparata, 10～20 parts of Fructus Ligustri Lucidi, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of the Radix Paeoniae Albas, 10～20 parts of Myrrhas, 10～20 parts of Spica Prunellaes, 10～20 parts of Fructus Cnidiis, 10～20 parts of Herba Patriniae, 10～20 parts of Radix Scutellariaes, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Cortex Moutans.

The Chinese medicine preparation of described treatment chronic prostatitis, the ratio of weight and number of various crude drug can be 10～15 parts of Radix Rehmanniae Preparata, 10～15 parts of Herba Cynomoriis, 10～15 parts of the Radixs Astragali, 10～15 parts of Rhizoma Corydalis, 10～15 parts of Herba Epimedii, 10～15 parts of Semen Cuscutae, 10～15 parts of Herba Ecliptaes, 10～15 parts of Fructus Schisandrae Chinensis, 10～15 parts of Herba Hedyotidis Diffusaes, 10～15 parts on Flos Carthami, 10～15 parts of Radix Polygoni Multiflori Preparata, 10～20 parts of Fructus Ligustri Lucidi, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of the Radix Paeoniae Albas, 10～20 parts of Myrrhas, 10～20 parts of Spica Prunellaes, 10～20 parts of Fructus Cnidiis, 10～20 parts of Herba Patriniae, 10～20 parts of Radix Scutellariaes, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Cortex Moutans.

The Chinese medicine preparation of described treatment chronic prostatitis, the ratio of weight and number of various crude drug is preferably: 10～20 parts of Radix Rehmanniae Preparata, 10～20 parts of Herba Cynomoriis, 10～20 parts of the Radixs Astragali, 10～20 parts of Rhizoma Corydalis, 10～20 parts of Herba Epimedii, 10～20 parts of Semen Cuscutae, 10～20 parts of Herba Ecliptaes, 10～20 parts of Fructus Schisandrae Chinensis, 10～20 parts of Herba Hedyotidis Diffusaes, 10～20 parts on Flos Carthami, 10～20 parts of Radix Polygoni Multiflori Preparata, 10～15 parts of Fructus Ligustri Lucidi, 10～15 parts of Radix Salviae Miltiorrhizaes, 10～15 parts of the Radix Paeoniae Albas, 10～15 parts of Myrrhas, 10～15 parts of Spica Prunellaes, 10～15 parts of Fructus Cnidiis, 10～15 parts of Herba Patriniae, 10～15 parts of Radix Scutellariaes, 10～15 parts of Radix Angelicae Sinensis, 10～15 parts of Cortex Moutans.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of the Chinese medicine preparation of chronic prostatitis, and the dosage form of described preparation is a tablet, and preparation method comprises:

A. described crude drug is mixed, chopping is soaked;

B. the crude drug that soaks is added the water heating and refluxing extraction 2 times;

C. get the medicinal residues behind the above-mentioned water extraction again, add alcohol heating reflux and extract 2 times;

D. above-mentioned two kinds of extracting solution are merged decompression recycling ethanol and disinfectant preparation.

Among the described step b, can be with soaked crude drug heating and refluxing extraction 2 times, each 1～2 hour, 2 extracting solution are merged leave standstill.

Among the described step c, the medicinal residues that above-mentioned water extraction is crossed can be added 5～8 times of amount 60～70% alcohol heating reflux and extract 2 times, each 1～2 hour, 2 extracting solution merging be left standstill.

In the described steps d, above-mentioned two kinds of extracting solution can be merged, the concentrating under reduced pressure relative density is the filtrate of 1.35 (80 ℃), reclaim ethanol, gained filtrate adjusted proportion to 1.06, reduce pressure extractum, with CO 60 sterilizations, irradiation dose 8k adds starch or cane sugar powder and makes tablet.

For solving the problems of the technologies described above, the present invention provides a kind of preparation method for the treatment of the Chinese medicine preparation of chronic chronic prostatitis again, the dosage form of described preparation is a honey refining pill, its preparation method comprises: earlier described crude drug is ground into coarse powder, further pulverize again, cross 120 mesh sieves, the fine powder amount that enable pass is crossed 120 mesh sieves is reaching 30%, and the fine powder of collecting by 120 mesh sieves gets fine powder a; Can not drop into multi-function extractor by the coarse powder of 120 mesh sieves again and extract twice, and add 8-10 times of water gaging for the first time and decocted 1-2 hour, and add 4-8 times of water gaging for the second time and decocted 1-2 hour, merge decocting liquid twice, filter to get filtrate; Heating is concentrated into pasty state, puts into 80 ℃ in baking oven oven dry postcooling, grinds to form fine powder b, with a with call in Mel after b mixes and make the sweet pill that refines.

For solving the problems of the technologies described above, the present invention provides a kind of preparation method for the treatment of the Chinese medicine preparation of chronic prostatitis again, the dosage form of described preparation is a rectally suppository, its preparation method comprises: with 50 ℃～60 ℃ heating and melting of substrate, add the fine powder a and the b that adopt the described preparation method preparation of claim 8, stirring in water bath is even, is mixed into heavy-gravity liquid, be poured in the plastics calibration tube, cooling and shaping is made class warhead shape suppository; Described substrate is selected from: one or more in semi-synthetic fatty acid glyceride, poloxamer, Polyethylene Glycol, the lanoline.

The dosage form of the Chinese medicine preparation of described treatment chronic hepatitis B can for: decocting enema, tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, pill, powder, sublimed preparation, solution, injection, suppository, plaster, syrup or suppository.

Prepared slices of Chinese crude drugs decoct (enema): choose crude drug, fry in shallow oil with clear water 400ml and to be medicine soup 120ml, getting supernatant cold to medicine temperature is about 40 ℃, get lateral position after advising patient's defecation, insert the about 20cm of anus with anal canal, inhale medicinal liquid with the 50ml syringe and slowly pour into (or using the transfusion device infusion) capable retention enema of rectum from anal canal, the bed hedgehopping buttocks is flat slightly after the coloclysis crouched 30 minutes, every day, coloclysis was 1 time, and treating 10 days was 1 course of treatment.Or make behind the suppository with booster from anum administration, get lateral position after advising patient's defecation, add suppository with booster and insert the about 20cm administration of anus.

During the per rectum administration, medicine can absorb 50%～70% at rectum, and does not directly enter 3 Venous systems of pelvic cavity viscera by liver, makes prostate rehabilitation rapidly under the medicine effective concentration effect.From anatomical angle, the anatomical position of prostate and rectum is adjacent, and the part has abundant blood vessel to be communicated with, and prostate peripheral lymphoid host will be at the prostate rear, and part lymph net and rectum have abundant traffic.Therefore, herbal retention enema or suppository can make medicine absorb by rectal mucosa, and can there be higher concentration in through sick institute in the prostate of pathological changes, and therapeutic effect is more satisfactory, has also avoided some untoward reaction of oral medication and intravenous administration simultaneously.

The present invention adopts the blood circulation promoting and blood stasis dispelling Chinese herbal medicine, can improve capillary permeability, and the reaction that reduces inflammation promotes disappearing and absorbing of inflammation focus, improves connective tissue metabolism, can promote the conversion and the absorption of hypertrophy pathological changes, can make the connective tissue rehabilitation of atrophy again.During the per rectum administration, medicine can absorb at rectum, and does not directly enter 3 Venous systems of pelvic cavity viscera by liver, makes prostate rehabilitation rapidly under the medicine effective concentration effect.Coloclysis or suppository can make medicine absorb by rectal mucosa, and can there be higher concentration in through sick institute in the prostate of pathological changes, and therapeutic effect is more satisfactory, has also avoided some untoward reaction of oral medication and intravenous administration simultaneously.The present invention is cheap, and preparation method is simple and easy to do, can create good social benefit and economic benefit.

The specific embodiment

The chronic prostatitis traditional Chinese medical science is called " nebulousurine ", and " smart turbid ", " element is asked the regulating menstruation opinion ": few sun is in spring, and the visitor wins, and very then descends albiduria white." beautiful machine is really hidden opinion ": stuffy feverish sensation in the lower abdomen and disease goes out white." miscellaneous diseases source and course rhinoceros candle five types of stranguria reddish and whitish turbid urine source and course ": excessive in vain, the heat stagnation disease also, a legendary venomous insect.The kidney pulse passes through ridge, the genus kidney, and the network bladder, so lower abdomen injustice heat and pain are urinated out white liquid also, in view of the above, then spleen is subjected to ailment said due to cold or exposure and passes in kidney, wind energy is incited heat, so accumulation of pathogenic heat in the interior, very essence is not kept, and thing is swum excessive and is gone out in vain." nephropathy from the therapy stranguria with turbid discharge from the therapy nebulousurine from the beginning of autotherapy ": after the urine, ooze out seminal fluid, as slurry, superficial as water from washing rice, its nebulousurine belongs to due to the heat of bladder water channel more.Prostatitis is not rarely seen in ancient times, and more perfect argumentation has been arranged, the traditional Chinese medical science is thought, its pathogenic factor is mainly damp and hot descending, and stagnant heat hinders in the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, so that smart road is unfavorable and sick, its TCM Syndrome Type is with varied, but recently relevant scholar's research is found chronic prostatitis based on damp-heat type, blood stasis type, and occurs merge of two cards more, has reached 78.59% of total case load.

Chronic prostatitis belongs to categories such as the traditional Chinese medical science " nebulousurine ", " seminal emission ", " smart turbid ".Many because desire is unsuccessful, or excess of sexual intercourse, causing hyperactivity of the ministerial fire, heat is compeled smart chamber, and external orifice of urethra adularescent secretions overflows; Eating and drinking without temperance, retention of damp-heat in the interior, or diseases caused by exogenous pathogenic factor seasonal pestilence cause the damp-heat accumulation part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, frequent micturition occurs, and urine is anticipated endless, and obstinate or malpractice cause the smart road of damp and hot stagnation of blood stasis, perineal position, lumbosacral region.Testis or vague pain and uneasy over the lower abdomen.Primary disease is damp and hot, and stagnation of blood stasis is in the external genitalia, and the smart chamber stasis of blood hinders, so control with blood circulation promoting and blood stasis dispelling, clearing away heat-damp and promoting diuresis is the Therapeutic Principle.Modern medicine is thought, chronic prostatitis is sent out in person between twenty and fifty well, cause prostata tissue chronic congestion and edema in the sexual maturity stage because of excessive or frequent libido, pathological manifestations is that prostata tissue inflammation sample becomes, but the massive inflammatory cells infiltrated due to the pathogenic infection is seldom arranged.Traditional medicine thinks that chronic prostatitis renal deficiency type basic pathogenesis is this for suffering from a deficiency of the kidney, and blood stasis is auxilliary.Coloclysis Chinese medicine is the Therapeutic Principle at pathogenesis with the invigorating kidney, promoting blood circulation.During chronic prostatitis, because prostate inflammatory plumpness, compressing back urethra causes that urine is smooth, drop is short of, desires separate to separate, and influences the scorching district of antibiotic infiltration and plays a role.Modern pharmacological research confirms that drug for invigorating blood circulation and eliminating stasis can improve capillary permeability, the reaction that reduces inflammation, and disappearing and absorbing of promotion inflammation focus improves connective tissue metabolism, can promote the conversion and the absorption of hypertrophy pathological changes, can make the connective tissue rehabilitation of atrophy again.During the per rectum administration, medicine can absorb 50%～70% at rectum, and does not directly enter 3 Venous systems of pelvic cavity viscera by liver, makes prostate rehabilitation rapidly under the medicine effective concentration effect.From anatomical angle, the anatomical position of prostate and rectum is adjacent, and the part has abundant blood vessel to be communicated with, and prostate peripheral lymphoid host will be at the prostate rear, and part lymph net and rectum have abundant traffic.Therefore, herbal retention enema or suppository can make medicine absorb by rectal mucosa, and can there be higher concentration in through sick institute in the prostate of pathological changes, and therapeutic effect is more satisfactory, has also avoided some untoward reaction of oral medication and intravenous administration simultaneously.

Ancient Times in China medical science is with acute and chronic prostatitis ownership " stranguria " category.China's tradition traditional Chinese medical science early has penetrating argumentation for prostatitis.The time enter Weihe as Xu of the Qing Dynasty: " turbid person, white sticking as smart shape flows out from stem, and is not puckery bitterly, and accounting for down clothing has the mark person is also." add: " and smart turbid person, stem seemingly lancinates fiery bright, and the key of drowning, the disease being located in the liver spleen; Turbidly go out orifice for discharging seminal fluid, the disease being located in the heart kidney." clinical findings, primary disease major lesions position is at kidney, and is also relevant with bladder, heart spleen, liver etc., and " orifice for discharging seminal fluid " should be the histoorgan that seminal fluid is formed in secretions such as prostate, seminal vesicle, cowper gland.The primary disease cause of disease is intricate, generally speaking be lose smart become silted up turbid, damp invasion of lower energizer, smart close solid.Main diseases is because of being " bearing essence " and " infection ".The former is many by the mutually fiery movability of person between twenty and fifty, be willing to unsuccessfully, essence stays in, and becomes silted up in smart chamber; Or seminal emission, masturbation, cause in terror, bear essence and do not penetrate, lose smart multiple abscess, satisfy into turbid essence.The latter is how plain empty by the spleen lung, the priming damp-heat in lower-JIAO; Or redundant prepuce, sexual intercourse is unclean, and damp and hot heresy is invaded on the key by urine, scurries in essence is turbid and mixes mutually, smartly forms primary disease from it.The food greasy and surfeit flavour is had a liking in excessive drinking smoking, rises in also can be damp and hot, makes a bet smart chamber and causes primary disease.Generally, with damp-heat syndrome, congestion, middle deficient syndrome, kidney deficiency are main cause and carry out the classification of disease type acute and chronic prostatitis on endogenous cause of ill.

The present invention is with heat-clearing and toxic substances removing, and blood circulation promoting and blood stasis dispelling, inducing diuresis for treating stranguria syndrome are the rule of treatment, and primary disease is damp and hot, and stagnation of blood stasis is in the external genitalia, and the smart chamber stasis of blood hinders, so control with blood circulation promoting and blood stasis dispelling, clearing away heat-damp and promoting diuresis is the Therapeutic Principle.Modern medicine is thought, chronic prostatitis is sent out in person between twenty and fifty well, cause prostata tissue chronic congestion and edema in the sexual maturity stage because of excessive or frequent libido, pathological manifestations is that prostata tissue inflammation sample becomes, but the massive inflammatory cells infiltrated due to the pathogenic infection is seldom arranged.Traditional medicine thinks that chronic prostatitis renal deficiency type basic pathogenesis is this for suffering from a deficiency of the kidney, and blood stasis is auxilliary.Coloclysis Chinese medicine is the Therapeutic Principle at pathogenesis with the invigorating kidney, promoting blood circulation.During chronic prostatitis, because prostate inflammatory plumpness, compressing back urethra causes that urine is smooth, drop is short of, desires separate to separate, and influences the scorching district of antibiotic infiltration and plays a role.Modern pharmacological research confirms that drug for invigorating blood circulation and eliminating stasis can improve capillary permeability, the reaction that reduces inflammation, and disappearing and absorbing of promotion inflammation focus improves connective tissue metabolism, can promote the conversion and the absorption of hypertrophy pathological changes, can make the connective tissue rehabilitation of atrophy again.During the per rectum administration, medicine can absorb 50%～70% at rectum, and does not directly enter 3 Venous systems of pelvic cavity viscera by liver, makes prostate rehabilitation rapidly under the medicine effective concentration effect.From anatomical angle, the anatomical position of prostate and rectum is adjacent, and the part has abundant blood vessel to be communicated with, and prostate peripheral lymphoid host will be at the prostate rear, and part lymph net and rectum have abundant traffic.Therefore, herbal retention enema or suppository can make medicine absorb by rectal mucosa, and can there be higher concentration in through sick institute in the prostate of pathological changes, and therapeutic effect is more satisfactory, has also avoided some untoward reaction of oral medication and intravenous administration simultaneously.

Radix Astragali QI invigorating yin fluid astringing in the side helps QI invigorating to give birth to the power of the moon; Radix Angelicae Sinensis is nourshing Yin and drynsessmoistening prescription, clearing heat and relieving fidgetness; Herba Hedyotidis Diffusae, Herba Patriniae heat-clearing and toxic substances removing, eliminating dampness and astringing sores, reinforcing spleen and kidney; Radix Paeoniae Alba medicine carrying is up, makes the efficacy of a drug up, but qi and blood circulation promotion is grown and oiliness all medicines, and benefit is not stayed the stasis of blood; Spica Prunellae antiinflammatory blood stasis dispelling, the removing heat from blood coordinating the actions of various ingredients in a prescription; All medicines share mends double the executing of row, plays benefiting qi and nourishing yin altogether and nourishes blood, the merit of promoting flow of QI and blood pain relieving.The Fructus Cnidii bactericidal antiphlogistic, Radix Scutellariae removing heat from blood toxin expelling, evacuation of pus, expelling pus and promoting granulation; Myrrha, Fructus Ligustri Lucidi, Fructus Schisandrae Chinensis anti-inflammation and sterilization, the effect that the foster skin of invigorating blood circulation, heat-clearing and toxic substances removing, granulation promoting are put on flesh, Radix Polygoni Multiflori Preparata, Herba Cynomorii, Radix Rehmanniae Preparata, Herba Epimedii the kidney invigorating and essence nourishing, treatment impotence and premature ejaculation, the moon Sanguis Draxonis that declines; The good medicine of the weak deficiency of YIN of gas; Flos Carthami, Radix Salviae Miltiorrhizae blood circulation promoting and blood stasis dispelling, the Cortex Moutan heat clearing away; All medicines have share the spleen invigorating eliminating dampness by diuresis, the effect that heat-clearing and toxic substances removing, eliminating dampness and astringing sores, granulation promoting are put on flesh, can improve capillary permeability, reaction reduces inflammation, promote disappearing and absorbing of inflammation focus, improve connective tissue metabolism, can promote the conversion and the absorption of hypertrophy pathological changes, can make the connective tissue rehabilitation of atrophy again.

The Radix Astragali is based on tonify deficiency, can invigorating QI to consolidate the body surface resistance, and diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Be used for that insufficiency of vital energy and blood, skin infection cave in, difficulty in discharging of pus or burst for a long time and do not hold back the person.The Radix Astragali has the function of good promoting pus discharge and tissue regeneration strengthening, i.e. the abscess suppuration granulation promoting of disunion for a long time.Modern medicine study shows that the Radix Astragali includes and multiple antibiotic effective ingredient, and the energy enhancing body's immunological function, therefore can also be used to prevent the generation of some infectious disease." book on Chinese herbal medicine meets former " carries: " Radix Astragali can all void of tonifying five ZANG-organs, controls the stringy pulse spontaneous perspiration, rushes down YIN-fire, removes lung-heat, losslessly then sends out, and has antiperspirant then to end." be the good medicine of promoting resistance and defence disease.

The Radix Paeoniae Alba goes into liver, spleen channel, nourishing blood to suppress the hyperactive liver, and slow middle pain relieving, yin fluid astringing is received antiperspirant.Control the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia, married woman's blood closes obstructed, and repercussive blood can lose pus, beneficial woman's blood." Japan hanako materia medica ": control wind, mend labor, all diseases of main woman, and all diseases in antenatal back, Tong Yueshui brings down a fever, relieving restlessness, QI invigorating, day hot disease of row, the pestilence miasma, mania and irritation, married woman's blood fortune, and hemorrhoidal hamorrhage are rushed down blood, hemorrhoid complicated by anal fistula.Carbuncle on the back, the skin ulcer scabies, headache makes eye bright, and conjunctival congestion is exerted meat.The many QI invigorating of redness of the skin or complexion person, white person controls blood.

The little hardship of Spica Prunellae, liver heat removing, eliminating stagnation, diuresis; Control diseases such as pestilence, acute mastitis, ophthalmalgia, jaundice, gonorrhea, hypertension; Control that lymphoid tuberculosis, thyromegaly, scrofula, goiter, acute mastitis, breast carcinoma, order pearl nyctalgia, photophobia are shed tears, the vertigo, facial hemiparalysis, bones and muscles pain, pulmonary tuberculosis, acute icteric infectious hepatitis, metrorrhagia, leukorrhagia.Spica Prunellae is the key medicine of clearing away liver-fire, Disperse hepatic depression, and what it cured mainly is the disease of Liver Channel mostly.This product is equipped with Flos Chrysanthemi, Semen Cassiae, but liver heat removing and eyesight improving control conjunctival congestion and swelling pain, be equipped with Concha Haliotidis, Ramulus Uncariae Cum Uncis, but the pancake liver-yang is controlled headache, dizziness; Be equipped with product such as Radix Scrophulariae, Bulbus Fritillariae Uninbracteatae, Concha Ostreae, but hard masses softening and resolving is controlled scrofula and is gone through tuberculosis." the southern regions of the Yunnan Province book on Chinese herbal medicine ": the liver-wind of dispelling, the network of passing through is controlled facial hemiparalysis.The row irritability is opened stagnation of liver-QI, ends bones and muscles pain, ophthal malgia, and the scrofula of loosing is stolen, whole body tuberculosis.

Herba Hedyotidis Diffusae is Herba Hedyotidis Diffusae, two leaves, Herba Commelinae Bengalensis, Chinese Lobelia again.Mildly bitter flavor, sweet, cold.Go into stomach, large intestine, small intestine meridian, the clearing up internal heat by using drugs of bitter in taste and cold in nature detoxifcation, sweet cold eliminating damp-heat has stronger removing toxicity for eliminating carbuncles effect to carbuncle, pharyngalgia, snakebite etc.Generally be used for the treatment of sore, laryngopharynx swelling and pain, abdominalgia with intestinal abscess, venom, also be used for the puckery pain of pyretic stranguria, dysuria.Be the good medicine of damp eliminating of drawing out pus by applying a plaster to the affected part.

Radix Scutellariae has heat clearing and damp drying, and removing heat from blood is antiabortive, detoxicating functions.Cure mainly diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.The clinical practice of Radix Scutellariae is antibiotic not worse than Rhizoma Coptidis, and does not develop immunity to drugs.We are by the strong characteristics of broad-spectrum antibacterial action, and it is special severe to be used in the fungal culture microbial contamination, and are fine with Radix Scutellariae extracting solution effect." Bencao Jingshu ": Radix Scutellariae, its property is respectful clearly, so remove evil: so bitter in the mouth dampness; So YIN-cold wins heat, so main all heat.All hot persons, pathogenic heat with all over heat also, jaundice, intestinal be out-of-the-way, let out dysentery, the disease of all damp and hot victory is also analysed it, then all diseases are from recover.Bitter cold can be removed damp and hot, thus small intestinal profit and water from pursuing, the source is clearly then flowed also clean.The blood person of closing, excess-heat is at blood system, instant heating human blood chamber, it is obstructed to make us amenorrhea, damp and hot separating, then Ying Qi is clearly and voluntarily also.Malignant boil cellulitis erosion person, heat in blood is then stayed knot, and is that carbuncle stain is mashed also: the acute scleritis person, the fire of moxibustion blood trouble also, the removing heat from blood heat extraction, then spontaneous recovery also.Radix Scutellariae has antiallergic action and antiinflammatory action: contained baicalin of Radix Scutellariae and baicalin can obviously suppress sensitized guinea pig rat small intestine in vitro and isolated tracheal to anaphylaxis contractile response that antigen produced, to passive general allergy and the Cavia porcellus passivity skin allergic reaction of Cavia porcellus and mice, baicalin and baicalin also have inhibitory action.Radix Scutellariae has refrigeration function, most evidences, and the active ingredient baicaligenin of Radix Scutellariae has refrigeration function.Radix Scutellariae has Detoxication, and baicalin has tangible Detoxication, and this may be because under the effect of glucuronidase, and baicalin decomposites glucuronic acid, and with due to multiple poisonous substance combines.10 milligrams of LD 50 that can improve strychnine of baicalin reach 2.5 times, and the hepatic glycogen content of carbon tetrachloride poisoning mice is increased.

The Chinese medicine Radix Polygoni Multiflori has the branch of Radix Polygoni Multiflori and Radix Polygoni Multiflori Preparata, and direct slicing is used as medicine and is Radix Polygoni Multiflori, mixes to dry to be used as medicine after the steaming with the Semen sojae atricolor liquor to be Radix Polygoni Multiflori Preparata.The function of the two is different: the detoxifcation of Radix Polygoni Multiflori function, eliminating carbuncle, loosening bowel to relieve constipation are usually used in treating scrofula carbuncle sore, rubella pruritus, dryness of the intestine constipation; The invigorating the liver and kidney of Radix Polygoni Multiflori Preparata function, benefiting essence-blood, black beard and hair, bone and muscle strengthening are used for blood deficiency and yellow complexion, vertigo and tinnitus, early whitening of beard and hair, soreness of the waist and knees, numb limbs and tense tendons, bleeding not during menses, chronic malaria body void etc.Radix Polygoni Multiflori Preparata of the present invention is the good merchantable brand of invigrating kidney.

The Radix Salviae Miltiorrhizae hardship is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, relieving restlessness clears away heart-fire.Be used for menoxenia, the amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia.Be used for the costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen caking, skin infection swells and ache, the tumbling down pain of injury, menoxenia, the amenorrhea dysmenorrhea, puerperal stasis of blood pain etc.Treatment costa sternales pain, lump in the abdomen caking, and menoxenia, amenorrhea dysmenorrhoea have good effect.. " detailed outline " carries: Radix Salviae Miltiorrhizae, by " the sensible opinion of married woman " cloud, SIWU TANG is controlled the gynecopathy, pays no attention to antenatal puerperal, through water what, all can be general, only flavor Radix Salviae Miltiorrhizae looses, and cures mainly identical with it.The lid Radix Salviae Miltiorrhizae can break stagnated blood, mends fresh blood, peaceful tire, and the stillborn fetus that falls ends the metrorrhagia dysentery, the regulating menstruation arteries and veins.

The sweet acid of Herba Ecliptae nature and flavor, removing heat from blood, hemostasis, the kidney invigorating, tonifying YIN.Control haematemesis, hemoptysis, epistaxis, hematuria is had blood in stool, dysentery, knife injury is hemorrhage, early whitening of beard and hair, diphtheria, stranguria with turbid discharge, leukorrhagia, pudendum pruritus due to damp pathogen.Compendium of Material Medica says that it can " black moustache be sent out, kidney tonifying the moon." " book on Chinese herbal medicine justice " think that Herba Ecliptae " goes into the kidney nourishing YIN and the hair of growing.”

Semen Cuscutae Gan Xinping goes into liver, kidney channel.The kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity, antiabortive.Be used for caused by liver and kidney deficiency, soreness of waist and knee joint, impotence and seminal emission, frequent urination and enuresis, two blurred visions are dark, diseases such as frequent fetal movement.The function tonification Liver and kidney, the controlling nocturnal emission with astringent drugs reducing urination, antiabortive, make eye bright antidiarrheal.Being used for impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness of the waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, spleen suffers from a deficiency of the kidney and rushes down.

Radix Angelicae Sinensis, its sweet in the mouth and weighing, so specially can enrich blood, its gas is light and hot, thus again can promoting the circulation of blood, invigorating middle warmer has, in the row benefit is arranged, the gas medicine in the sincere blood, the also panacea in the blood.About mending of assistant to mend then, thus can support nutrition blood, the QI invigorating spermatogenesis, settling five organs, body by force, beneficial mind, all tangible deficient diseases, nothing is unsuitable.Assistant logical to attack then, so the relieving constipation bitterly of dispelling, relieving rigidity of muscles and joints is controlled contracture, paralysis, card such as dry, puckery.Nutrient QI being deficient and exterior syndrome being not relieved person, assistant is with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, the Biao Weire that can loose greatly, and show not hold back the person, and help with Radix Et Rhizoma Rhei and so on, again can consolidating superficial resistance.Precisely because gas Xin Erdong, so desire its quiet person when keeping away it, the sliding benefaction of property is defecated and is not consolidated the person when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable.

Herba Epimedii suffering, sweet, warm is returned liver, kidney channel.The energy reinforcing the kidney and supporting YANG, strengthening the tendons and bones, expelling wind and removing dampness is apt to control insufficiency of kidney-YANG, impotence and seminal emission, enuresis frequent micturition; Rheumatic arthralgia, atrophic debility of bones paralysis disease." book on Chinese herbal medicine is stated " cloud " excessive sheep fire, " herbal classic " medicine master impotence is hindered extremely, the exhausted sun of " solar corona " also first its treatment of speech man, the woman is exhausted cloudy, and then calling the gate of vitality, mending the kidney-Yang person is also.The lid gate of vitality be a kidney-Yang in the kidney, promptly the vigour of the person also, its what is called is YANG exhaustion the moon extremely, the vigour of basis not, how hiss in both withered.So-called physical strength profiting, strong will, and control the cold air consumptive disease, and the anxious card that waits of muscles and bones contraction, all it helps the event of vigour.Old man's dusk octogenarian, the middle age is forgetful, all Yuanyang decay and can not ascensionist also.Must know this flavor to reduce to liter, it rises owing to can fall also.”

Radix Rehmanniae Preparata is sweet, tepor.Return liver, kidney channel.Function cures mainly nourishing YIN and supplementing blood, and beneficial essence is filled out marrow.Be used for the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, the night sweat seminal emission, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, metrostaxis, dizzy, tinnitus, early whitening of beard and hair.

Fructus Cnidii suffering, hardship, temperature; Slightly poisonous.Return kidney channel.Cure mainly warming the kidney to invigorate YANG, dampness is dispeled the wind, parasite killing.Be used for sexual impotence, cold womb, cold-damp leukorrhagia, arthralgia chiefly caused by damp pathogen lumbago; The external treatment vulval eczema, married woman's pudendal pruritus; Trichomonal vaginitis is gynecological external use good medicine." Bencao Jingshu " carries: Fructus Cnidii, and bitter in the mouth is flat; " not Lu " be hot sweet nontoxic; Modern detailed its abnormal smells from the patient, when the warm-dryness syndrome of must holding concurrently, sun also.So swell and ache in housewife people's the moon, man's impotence pruritus due to damp pathogen removes stagnated QI, sharp joint, malignant boil." not Lu " warming the middle warmer and descending qi makes married woman's Zifu heat, and the man is cloudy strong, has made us son.Lid can dehumidify with tongue, temperature energy cold expelling, and suffering can be moistened kidney, and sweet energy strengthening the spleen is so can remove the wet disease of viscera connecting with this channel of all deficiency and coldness of married woman man.Cold-damp was both removed, and then disease is gone, performance Yiyang, thus disease, and have tonification also.

The Cortex Moutan bitter in the mouth is slightly cold, can clearing heat in YING system branch, blood system excess-heat, the merit of cooling blood for hemostasis is arranged.Control epidemic febrile disease heat and go into nutrient blood, the absurd row of forcing blood.Return Liver Channel.Function cures mainly clearing away heat and cooling blood, eliminating stasis to stop pain.Be used for maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, lump in the abdomen stomachache, injury from falling down, carbuncle skin infection.The effect of Cortex Moutan clearing away heat and cooling blood is preferable, and the branch excess-heat that can purify the blood can be controlled fever due to yin deficiency again." herbal classic " carries it: " main cold and heat, the apoplexy contract is removed hard disease blood stasis and is stayed the house the intestines and stomach from, convulsion, infantile convulsion pathogen, and settling five organs is treated the carbuncle skin ulcer.

The Fructus Schisandrae Chinensis temperature; Sour, sweet; Return lung, the heart, kidney channel; Restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.Be used for the chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, the deficient pulse of losing heart, interior-heat is quenched one's thirst, palpitation and insomnia." Bencao Jingshu " carries: Fructus Schisandrae Chinensis master QI invigorating person, and all gas of lung master, acid can be received, and is just going into the lung tonifying the lung, so QI invigorating is also.Its main cough with dyspnea person, the deficiency of vital energy then goes up heap soil or fertilizer over and around the roots and does not return unit, and sour flavor having the property of astringing is taken the photograph gas and is returned unit, and then cough with dyspnea is from removing.Impairment caused by overstrain is won thin, tonifying for the deficiency, reinforcing YIN-essence, beneficial man's essence." not Lu " supports the five internal organs, and heat extraction is given birth to flesh person in the moon, the special the kidney invigorating of Fructus Schisandrae Chinensis, the tonifying five ZANG-organs of holding concurrently, kidney storing essence is smartly contained then cloudy by force, receives and take the photograph then vital qi and return unit, and the public region is warm, digesting food, steam waste matter and change precise and tiny, then smart spontaneous, smart give birth to then cloudy long, so the as above all diseases of master are also.

Fructus Ligustri Lucidi is used for the poor vision of the hepatic and renal YIN deficiency, visual deterioration, early whitening of beard and hair, soreness of waist tinnitus and fever due to yin deficiency etc.This product energy tonifying liver kidney yin, but the efficacy of a drug is gentle, must slowly get effect.Control poor vision, often join Radix Rehmanniae Preparata, Fructus Lycii is equal to usefulness, controls early whitening of beard and hair, often joins the same usefulness of Fructus Mori, and Cortex Lycii is often joined in fever due to yin deficiency.The hepatic and renal YIN deficiency, Light-headedness, seminal emission tinnitus, soreness of the waist and knees, early whitening of beard and hair, coronary heart disease, hyperlipemia, hypertension, chronic hepatitis.Protective effect research to liver is thought, Fructus Ligustri Lucidi contains oleanolic acid, give rat skin lower injection, can reduce serum glutamic pyruvic transminase, the hepatic injury that carbon tetrachloride is brought out has obvious protective effect, and can promote liver cell regeneration. and oleanolic acid also can make in the liver triglyceride accumulate that minimizings, hepatocellular degeneration necrosis obviously alleviate, glycogen is accumulated increase, serum decline; Mitochondrial swelling and the degeneration of endoplasmic reticulum vesicle alleviates, the matter inflammatory reaction weakens between hepatic tissue in the visible hepatocyte of ultrastructure.

Flos Carthami is warm in nature, acrid in the mouth.Cure mainly the latus rectum of invigorating blood circulation, eliminating stasis to stop pain.Be used for that amenorrhea, dysmenorrhea, lochia are not all right, lump in the abdomen mass in the abdomen, traumatic injury." book on Chinese herbal medicine converges and says ": Flos Carthami, the medicine of removing blood stasis, promoting the circulation of blood and blood, accent blood also.Main tire produces all kinds of diseases and ailments and is trouble because of blood, or the tired bruise of blood, and coma in silence; Or lochia is robbed the heart, the umbilicus angina abdominis; Or the drop slurry is difficult living; Or afterbirth do not fall, and dead fetus in the uterus is all just before giving birth all cards, and non-Flos Carthami can not be controlled.If puerperal blood faints, locked mouth refer to hold in the hand; Or heresy goes into the blood chamber, and delirium is gone mad; Or blood expands in vexed, and the sudden syncope with rigidity is as extremely, be all puerperal all cards, non-Flos Carthami can not be decided.All friendship as the obstructed and cold and heat of amenorrhea done, or expired stomachache and purple black dripping, or injury from falling down and the QI and blood stasis of blood is long-pending, or skin infection sufferings and swollenly burst uneasyly, is cards of disharmony between QI and blood all, and non-Flos Carthami can not be transferred." medicine justice ": Flos Carthami, kind tonneau passages through which vital energy circulates is gas medicine in the blood, can rush down and can mend, and wonderful justice is respectively arranged.If how with three, four money, then too hot warm, blood is wandered away.With Lignum Sappan removing blood stasis blood, to close Cortex Cinnamomi and stimulate the menstrual flow and close, assistant is returned, Chinese herbaceous peony is controlled all over or the pricking caused by the stagnation of QI and blood of breast abdomen, and this its row is led and is invigorated blood circulation also.If use seven, eight fens less, with dispersing liver-energy, helping the sea of blood, the void of enriching blood greatly, this its transfer smooth and and blood also; If end with two, three minutes, go into the heart to join painstaking effort, dismiss heart channel pathogenic fire, make the blood mediation, this its nourishing and hemopoietic are also; The justice of component number, meagre.

The Herba Patriniae nature and flavor are bitter flat, have the effect of heat-clearing and toxic substances removing, evacuation of pus removing blood stasis with potent drugs.Can cure acute appendicitis, dysentery, leucorrhea with red and white discharge, the stagnant stomachache of the stasis of blood in puerperal, conjunctival congestion and swelling pain.Go into stomach, large intestine, Liver Channel.Cure mainly heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, blood circulation promoting competent silt.Be used for acute appendicitis, lung abscess and sore and toxic, the breast abdomen pain due to the excess-heat stasis of blood stagnates, the stagnant stomachache of the stasis of blood in puerperal waits disease.

The Myrrha blood blood stasis removing that looses, subduing swelling and relieving pain.Cure mainly traumatic injury, incised wound, muscles and bones, all pains of trusted subordinate, lump in the abdomen, amenorrhea, ulcer sore pain, anal fistula, diseases of the eye.Bitter in the mouth, suffering, flat.Go into liver, spleen, the heart, kidney channel." Bencao Jingshu " carries it: " the ulna arthralgia is coerced costalgia with husband's breast abdomen, non-retention of blood stasis and because of using in blood deficiency person.Lochia goes many, and empty pain person should not use in the abdomen.Carbuncle has been burst and should not have been used.The non-heat in blood of conjunctival congestion skin nebula very person should not be used." join Olibanum, promoting blood circulation to remove blood stasis, circulation of qi promoting Shujin.

The Herba Cynomorii sweet in the mouth, warm in nature.The energy kidney-replenishing, benefiting essence-blood, loosening bowel to relieve constipation.Can improve the immune system resistance; Remove free radical; Antiplatelet aggregation; Has the effect of saccharide 17-hydroxy-11-dehydrocorticosterone sample.Clinically cure mainly: impotence and premature ejaculation, the moon Sanguis Draxonis that declines with Herba Cynomorii; The weak deficiency of YIN of gas, constipation due to dry stool, frequent micturition, hematuria, not to the utmost dripping; Soreness of the waist and knees, fatigue and weak; Fear of cold is all cold, limbs pain; Menoxenia, the cold womb leukorrhagia; Infertilitas feminis, male infertility; Insomnia forgetfulness, alopecia are early white, gastric acid ulcer or the like.Up-to-date medical research is found: Herba Cynomorii can promote human body cell regeneration and metabolism, and the enhance immunity regulating power has tangible anti-cancer, antiviral and delaying senility function.In recent years, all obtained good effect with Herba Cynomorii treatment prostate hyperplasia and hypertrophy, treatment leukemia, treatment diabetes, treatment asthma, treatment premature ejaculation.

Rhizoma Corydalis is the stem of determining of Papaveraceae herbaceos perennial Rhizoma Corydalis.Its acrid in the mouth, hardship, warm in nature, GUIXIN, liver, spleen channel.Have invigorate blood circulation, the effect of circulation of qi promoting, pain relieving.For invigorate blood circulation, the good medicine of promoting the circulation of QI, pain relieving.Rhizoma Corydalis beginning is carried " Kaibao Bencao ", say its " main removing blood stasis, puerperal all cause of disease blood person of being; Married woman's menoxenia is lumpd in the abdomen, and metrorrhagia is drenched and revealed, and puerperal, blood was transported, and sudden and violent blood rushes to, because of decreasing hematochezia.Or wine rubs and boils clothes ".Materia Medica of Decoction says that it " controls motive lower abdominal pain, god is arranged ".Compendium of Material Medica is sayed its " promoting the circulation of QI of invigorating blood circulation, pain relieving, diuresis ", " stagnation of QI in the energy promoting the circulation of blood, stasis in the gas.So all pains about specially controlling all over the body ", " pained desire is dead, and speed is looked for Rhizoma Corydalis ".

The manufacturing process of honey pill agent of the present invention is: with Radix Rehmanniae Preparata 1000g, and Herba Cynomorii 1000g, Radix Astragali 1000g, Rhizoma Corydalis 1000g, Herba Epimedii 1000g, Semen Cuscutae 1000g, Herba Ecliptae 1000g, Fructus Schisandrae Chinensis 1000g, Herba Hedyotidis Diffusae 1000g, Flos Carthami 1000g, Radix Polygoni Multiflori Preparata 1000g, Fructus Ligustri Lucidi 1000g, Radix Salviae Miltiorrhizae 1000g, Radix Paeoniae Alba 1000g, Myrrha 1000g, Spica Prunellae 1000g, Fructus Cnidii 1000g, Herba Patriniae 1000g, Radix Scutellariae 1000g, Radix Angelicae Sinensis 1000g, Cortex Moutan 1000g mixes, and earlier described crude drug is ground into coarse powder, further pulverize again, cross 120 mesh sieves, the fine powder amount that enable pass is crossed 120 mesh sieves is reaching 30%, and the fine powder of collecting by 120 mesh sieves gets fine powder a; Can not drop into multi-function extractor by the coarse powder of 120 mesh sieves again and extract twice, and add 8-10 times of water gaging for the first time and decocted 1-2 hour, and add 4-8 times of water gaging for the second time and decocted 1-2 hour, merge decocting liquid twice, filter to get filtrate; Heating is concentrated into pasty state, puts into 80 ℃ in baking oven oven dry postcooling, grinds to form fine powder b, with a with call in Mel after b mixes and make the sweet pill that refines.

The manufacturing process of tablet of the present invention is: with Radix Rehmanniae Preparata 1000g, and Herba Cynomorii 1000g, Radix Astragali 1000g, Rhizoma Corydalis 1000g, Herba Epimedii 1000g, Semen Cuscutae 1000g, Herba Ecliptae 1000g, Fructus Schisandrae Chinensis 1000g, Herba Hedyotidis Diffusae 1000g, Flos Carthami 1000g, Radix Polygoni Multiflori Preparata 1000g, Fructus Ligustri Lucidi 1000g, Radix Salviae Miltiorrhizae 1000g, Radix Paeoniae Alba 1000g, Myrrha 1000g, Spica Prunellae 1000g, Fructus Cnidii 1000g, Herba Patriniae 1000g, Radix Scutellariae 1000g, Radix Angelicae Sinensis 1000g, Cortex Moutan 1000g mixes, and chopping is soaked.With soaked crude drug heating and refluxing extraction 2 times, each 1～2 hour, 2 extracting solution are merged leave standstill.The medicinal residues that above-mentioned water extraction is crossed add 5～8 times of amount 60～70% alcohol heating reflux extraction 2 times again, each 1～2 hour, 2 extracting solution merging are left standstill.Above-mentioned two kinds of extracting solution are merged, and the concentrating under reduced pressure relative density is the filtrate of 1.35 (80 ℃), reclaims ethanol, and gained filtrate is adjusted proportion to 1.06, reduce pressure extractum, with CO 60 sterilizations, irradiation dose 8k adds starch or cane sugar powder and makes tablet.Can per 24 be a plate.

The preparation method of capsule of the present invention comprises: get Radix Rehmanniae Preparata 1000g, Herba Cynomorii 1000g, Radix Astragali 1000g, Rhizoma Corydalis 1000g, Herba Epimedii 1000g, Semen Cuscutae 1000g, Herba Ecliptae 1000g, Fructus Schisandrae Chinensis 1000g, Herba Hedyotidis Diffusae 1000g, Flos Carthami 1000g, Radix Polygoni Multiflori Preparata 1000g, Fructus Ligustri Lucidi 1000g, Radix Salviae Miltiorrhizae 1000g, Radix Paeoniae Alba 1000g, Myrrha 1000g, Spica Prunellae 1000g, Fructus Cnidii 1000g, Herba Patriniae 1000g, Radix Scutellariae 1000g, Radix Angelicae Sinensis 1000g, Cortex Moutan 1000g mixes, and described component mixes by proportioning, drop into pulverizer and be ground into fine powder, put into the acid and alkali-resistance infusion kettle after fine powder sieves, at normal temperatures, flooded 10～20 days with ethanol is common, liquid and medicinal residues that dipping is good carry out squeeze and filter, get filtrate after the separation, heating is concentrated into pasty state and adds the dextrin mixing, granulates.

The preparation method of rectally suppository of the present invention comprises: with Radix Rehmanniae Preparata 1000g, and Herba Cynomorii 1000g, Radix Astragali 1000g, Rhizoma Corydalis 1000g, Herba Epimedii 1000g, Semen Cuscutae 1000g, Herba Ecliptae 1000g, Fructus Schisandrae Chinensis 1000g, Herba Hedyotidis Diffusae 1000g, Flos Carthami 1000g, Radix Polygoni Multiflori Preparata 1000g, Fructus Ligustri Lucidi 1000g, Radix Salviae Miltiorrhizae 1000g, Radix Paeoniae Alba 1000g, Myrrha 1000g, Spica Prunellae 1000g, Fructus Cnidii 1000g, Herba Patriniae 1000g, Radix Scutellariae 1000g, Radix Angelicae Sinensis 1000g, the water logging bubble that Cortex Moutan 1000g mixing adding 5-10 doubly measures 1-2 hour extracts 2 times; Heating extraction 1-2 hour, be concentrated into the extractum shape, become component 1; The residue medicinal residues added the 60-90% soak with ethanol 0.5-1.5 hour, extracted twice, each 1-2 hour, merge extractive liquid, filters, and concentrates, the 80-160 order filters, and the 6000-10000 rev/min of supernatant after centrifugal is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, ultrafiltrate concentrating under reduced pressure relative density is the extractum of 1.35 (80 ℃), heating and refluxing extraction 2 times each 30 minutes～45 minutes, is extracted active ingredient, 2 extracting solution merging are settled into the extractum shape, as component 2.Get the substrate heating and melting then, 50 ℃～60 ℃ of temperature add component 1 and component 2, also can use the fine powder a+b that obtains in the honey refining pill preparation method; Stirring in water bath is even, is mixed into heavy-gravity liquid, is poured in the plastics calibration tube, inserts tampon, and cooling and shaping is made similar bullet-shaped suppository; General used substrate can be: semi-synthetic fatty acid glyceride, lanoline, Polyethylene Glycol, and the proportioning of medicine fine powder and substrate is 1: 2～1: 4, is preferably 1: 3; Or adopt poloxamer poloxamer as substrate, softer, quick than the dissolubility of other substrate, drug loading is also higher.

Prepared slices of Chinese crude drugs decoct (enema): by the dialectical side of suiting the medicine to the illness that selects for use, fry in shallow oil with clear water 400ml and to be medicine soup 120ml, getting supernatant cold to medicine temperature is about 40 ℃, get lateral position after advising patient's defecation, insert the about 20cm of anus with anal canal, inhale medicinal liquid with the 50ml syringe and slowly pour into (or using the transfusion device infusion) capable retention enema of rectum from anal canal, the bed hedgehopping buttocks is flat slightly after the coloclysis crouched 30 minutes, every day, coloclysis was 1 time, and treating 10 days was 1 course of treatment.Or make behind the suppository with booster from anum administration, get lateral position after advising patient's defecation, add suppository with booster and insert the about 20cm administration of anus.

Pharmacology's toxicity test

One, antibacterial experiment

The antibacterial tests result shows that the present invention has significant protective effect to the animal of escherichia coli and Bacillus proteus in the body, can subtract the development of the state of an illness, reduces the mortality rate of animal; The in-vitro antibacterial experimental result shows, prostatitis urinary system bolt has in various degree antibacterial and bactericidal action to the antibacterial of urinary system infection; The prostatitic experimental result that influences of experimental rat is shown the present invention can suppress the weightening finish of prostate body of gland behind the bacterial infection, slow down the development of the state of an illness, the pathomorphism that suppresses prostata tissue changes; The urine amount of animal is obviously increased; Obvious cooling effect in 5 hours after the rabbit body temperature rising administration that fresh yeast is caused; The animal auricular concha swelling that xylol causes reaches has the obvious suppression effect to the granuloma induced by implantation of cotton pellets tissue, and suppresses the increase of capillary permeability; The pain that stimulates animal peritoneum or thermal stimulus animal body surface to cause to chemical substance has certain inhibitory action.

Two, animal acute toxicity test research:

When the present invention adopts the rectally approach, the maximum dosage-feeding on the one that records mice is 62.7g/kg (in a medicated powder), be about 1567.5 times (people is in 60kg) intending clinical people's consumption, the maximum dosage-feeding 62.7g/kg (in medicated powder) on the one of rat is about 1567.5 times that intend clinical people's consumption.Laboratory animal is all observed a week continuously, and its outward appearance sign, the mental status, diet, drinking-water, feces etc. show no obvious abnormalities.When experiment finishes, all healthy survival of animal, weight increase.

Three, long-term toxicity test for animals research:

Medicine height of the present invention is established in this test, in, low dose group and substrate matched group, the blank group, adopt the rectally approach to give rat, dosage is respectively 3.2,2.4 and 1.6g/kg (in medicated powder), be equivalent to intend 80 of clinical patient consumption [0.04g (medicated powder)/kg], 60 and 40 times, successive administration 2 months, in the administration process, the body weight of each administration group and matrix group rat, dietary amount, the outward appearance sign, behavioral activity, the mental status, hair color, feces character and blank group are relatively, no significant difference (P＞0.05), the weight of animals increasing value and main organs coefficient and blank group comparing difference be remarkable (P＞0.05) not, hematology and the indivedual indexs of blood parameters check result administration group and blank group comparing difference be (P＜0.05) significantly, but convalescent period finishes the discrepant hematology in back and blood parameters has all recovered normal, other indexs and blank comparing difference be remarkable (P＞0.05) not, administration phase and convalescent period histological examination high dose group animal main organs and blank group are not seen notable difference, do not see that slowness toxicity occurs.

Four, animal local excitation test:

The guinea pig skin hypersensitive test of suppository of the present invention and rat rectal application irritation test.The result shows: skin anaphylactic test, and high dose group 0.8g (medicated powder)/kg, low dose group 0.1g (medicated powder)/kg is equivalent to intend 20 times, 2.5 times of clinical people's consumption [0.04g (medicated powder)/kg] respectively, through the skin administration, there is no animal and produces allergy; Rectal application irritation test high dose group 5.0g (medicated powder)/kg, low dose group 3.2g (medicated powder)/kg, be equivalent to intend 125,80 times of clinical people's consumption respectively, in official hour, observe mucous membrane of rectum and all do not have phenomenons such as hyperemia, edema, histopathologic examination and blank group be no significant difference relatively, do not see and tangible irritative response occurs, every group of its overall health of patients of part animal of retaining, body weight, breathing, circulation, central nervous system and extremity activity etc., all Non Apparent Abnormality reactions.

The pharmacological experiment explanation:

1. test objective: observe and tried continuously one week of thing, to the inhibitory action of the swollen outgrowth inhibitory action of rat granuloma to kunming mice pain.

2. tried thing

Chinese medicinal tablet of the present invention; The SD rat that animal is provided by Shandong University's Experimental Animal Center, 4 months ages of Mus, body weight: test body weight 366 ± 24 (g of X ± SD).Sex: male; Every treated animal number: each 10; The raising condition: cleaning level Animal House, 22 ± 2 ℃ of temperature, humidity 45 ± 10%, rate of ventilation 12 times/minute is fed this center routine disinfection rat feed, drinks disinfectant, gregarious raising, 5 in every cage.Dosage is provided with and reason: with reference to the developmental pharmacology guideline, and the clinical plan dosage that hospital provides, the 2.25g/d that promptly is grown up presses the 60kg body weight and calculates 2.25g/d ÷ 60kg body weight: 0.0375g/kg/d.The animals administer amount by 2.5 times, 5 times, 10 times of clinical plan consumption establish little, in, big three dosage groups.(1) small dose group, 0.0375g/kgx2.5 times=0.09375g/kg/d; (2) dosage group in, 0.0375g/kgx5 times=0.1875g/kg/d, 0.0375g/kgx10 times=0.375g/kg/d of (3) heavy dose of group.

3. matched group

A. blank group: the disinfectant soup water that gives equal volume; B. aspirin group: 200mg/kg; C. QIANLIEKANG group: be equivalent to 5 times of clinical oral administration dosage.Adult 5g/d presses 60kg and calculates, be i.e. 5g ÷ 60kgx5 times=0.417g/kg/d; Every rat administration of administration volume capacity 10ml/kg, by equivalent different dosing concentration, medicine-feeding way filling stomach is identical with the clinical administration approach.Medicine and material: aspirin, Shanghai nine good fortune pharmaceutcal corporation, Ltds, lot number 001201, specification: the clinical consumption of 25mg/ sheet, 25-50mg/ day, oral.Lucifuge, sealing are preserved.QIANLIEKANG, pharmaceutical Co. Ltd of Kang Enbei group makes, lot number 000421-1, specification 0.5gx60 sheet/bottle, clinical consumption, a 3-4 sheet, 3 times on the one, oral.Rayon balls is made heavy 10 ± 1g, and size is close, and the about 7mm of diameter uses behind the autoclave sterilization.

4. test method

4.1 the medicine preparation: get tablet 3.75g of the present invention, be dissolved in the 100ml drinking water, being configured to 3.75% concentration is high dose group, and middle dosage group, small dose group are diluted 2 times, 4 times respectively.Get aspirin 2g, be dissolved in the 100ml disinfectant soup water, be configured to 2% concentration, get QIANLIEKANG 4.17g, be dissolved in the 100ml drinking water, be configured to 4.17% concentration.

4.2 animal model: rat under pentobarbital anesthesia, about tuck in nest and respectively cut an osculum, expand subcutaneous tissue with vascular forceps, the cotton balls of will sterilizing is implanted the rat both sides respectively, and to tuck in nest subcutaneous, sews up then, and postoperative begins by above-mentioned dosed administration next day, weighed in the 8th day, after the administration 2 hours,, peel off and take out the cotton balls granulation tissue with rat anesthesia, fatty tissue around picking to the greatest extent, 60 ℃ of following 12h, oven dry is weighed.

4.3 observation index granuloma net weight deducts the raw cotton ball weight with the granuloma weight of drying and is the granuloma net weight.

4.4 statistical method adopts OFFICE software, calculates the weight (organizing granulomatous index) of cotton balls under every 100g body weight, calculates its meansigma methods and standard deviation (X ± SD), carry out significant t-test again.

5. result and evaluation, result such as following table.

Tablet of the present invention is to the swollen outgrowth influence of rat granuloma

The result shows: each dosage group of tablet of the present invention and aspirin group, QIANLIEKANG group all have the chronic granuloma of inhibition hypertrophy, and tablet effect of the present invention is comparatively desirable.

Clinical data

1.1 diagnose and include in standard

Diagnosis is with reference to " new Chinese medicine clinical research guideline " and NIH's chronic prostatitis syndrome shape integral exponential (N IH2CPSI) standards of grading of Ministry of Public Health promulgation.The basic diagnosis standard is the conventional microscopy leukocyte of massage of prostate liquid (EPS) (WBC)＞10/HP, antibacterial culturing feminine gender, and 2 in following 3 are arranged in addition: 1. urinary tract infection symptom: frequent micturition, urgent micturition, dysurea, urine retention, urethra drip white; 2. pain symptom: position pain or discomforts such as waist sacrum, perineum, lower abdomen, testis; 3. sexual function is unusual: premature ejaculation, penile erectile function obstacle, hyposexuality.

1.2 exclusion standard is patient such as neurogenic bladder inflammation, tumor of bladder, vesical calculus, carcinoma of prostate and operation on prostate history person is arranged 1.; 2. the unusual person of hepatic and renal function; 3. adopt the medicine of other treatment prostatosis in two weeks, comprise antibiotic, receptor blocking agent, Chinese medicine preparation etc.

1.3 all cases of physical data derive from the prescription on individual diagnosis patient who comes the court reproductive medicine section from March, 2006～2009 year December.Be divided into two groups at random, 68 examples are organized in treatment, 21～48 years old age, the course of disease 7 months～10 years; Matched group 52 examples, 19～52 years old age, the course of disease 8 months～12 years.Two groups of patient ages, the course of disease have comparability through the equal not statistically significant of comparing difference (P＞0.05).

2 Therapeutic Method

2.1 the treatment group is taken from intending 1 dose of Chinese medicine decoction every day, decocting is 2 times continuously, and twice filtrate is mixed about 400ml mutually, 200ml/ morning and evening decoction being taken warmly.Took continuously 1 month.

2.2 the oral QIANLIEKANG PIAN of matched group (production of Zhejiang Kang Enbei company limited), each 3, every day 3 times, be 1 month the course of treatment.All carry out N IH2CPSI assessment, prostatic fluid and liver, renal function and blood, routine urianlysis before and after two groups of treatments.

3 therapeutic outcomes

The WBC counting is as the standard of efficacy determination among the scoring of reference " new Chinese medicine clinical research guideline " and NIH's chronic prostatitis syndrome shape integral exponential (N IH2CPSI) and the EPS.Cure: N IH2CPSI scoring reduces more than 95%, and the EPS microscopy is double normal; Produce effects: NIH2CPSI scoring reduces 60%～94%, and EPS microscopy WBC reduces 〉=60%; Effectively: the NIH2CPSI scoring reduces 30%～59%, and EPS microscopy WBC reduces 〉=30%; Invalid: the NIH2CPSI scoring reduces＜30%, and EPS microscopy WBC reduces＜30%.Two groups of therapeutic outcomes see Table 1, and treatment group total effective rate is 86.8%, and the matched group total effective rate is that 71.2%, two group of total effective rate compares, and difference has significance (χ 2=4.488, P＜0.05).

The comparison (%) of table 1 liang group therapeutic outcome

Group	Example number (n)	Cure	Produce effects	Effectively	Invalid
						Matched group	?52	12(23.1)	13(25)	12(23.1)	15(28.8)
The treatment group	?68	20(29.4)	21(30.9)	18(26.5)	9(13.2)

Annotate: total effective rate=cure rate+obvious effective rate+effective percentage, two groups of total effective rates compare P＜0.05

The curative effect of two groups of symptoms relatively sees Table 2, and the treatment group obviously is better than matched group (through chi-square criterion, P＜0.05) aspect patient's perineum discomfort, lower abdominal pain, phallodynia, orchiodynia, the penile erectile function improving; To improve patient's frequent micturition, the two groups of comparing differences in urine retention sense aspect do not have significance (through chi-square criterion, P＞0.05).Obvious adverse reaction after taking medicine, all patients is not all arranged.Blood, routine urinalysis and liver before and after the treatment, renal function are no abnormal.

The curative effect of table 2 liang group common sympton relatively

Annotate: P＜0.05

4 discuss

Chronic prostatitis is one of common disease of urinary system andrology, brings body misery and mental maladjustment to the patient, though Therapeutic Method is varied, curative effect is limited, is usually perplexing patient and doctor.Along with deepening continuously of studying over nearly 20 years, recognize that gradually chronic prostatitis is not a kind of simple disease, but have a class syndrome of specific manifestations separately.The sick position of primary disease is in part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels bladder and smart chamber, and with the passing of time damp and hot, the stagnation of QI, blood stasis consume and hinder healthy energy.Therefore, primary disease pathogenesis key is damp and hot, the stagnation of QI, blood stasis and the deficiency of vital energy.The lot of documents of comprehensive relevant primary disease, no matter be determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs, still specially square plus-minus is similar in the basic judgement of middle medical knowledge, method aspect.The curative effect of chronic prostatitis is not remarkable at present, and its basic reason is that the cause of disease is various, pathogenesis is complicated.But from clinically, improving aspects such as symptom, reduction expense, thorough healing, Chinese medicine has the advantage of himself.

The specific embodiment:

Specific embodiment 1: the gold certain, man, 47 years old, first visit on April 8 in 2008.The patient tells normal feel perineal position over 5 years, lower abdomen dull pain is easypro, and per rectum refers to inspection and prostatic fluid chemical examination, is diagnosed as chronic prostatitis, once repeatedly used antibacterials such as erythromycin, compound sulfamethoxazole, therapeutic effect is undesirable, and the state of an illness increases the weight of closely over the past half year, and the sex-linkage hypofunction.Examine quarter: perineal position and lower abdomen dull pain discomfort, and urinate back and normal after an action of the bowels adularescent secretions flow out from urethral orifice, sexual hypofunction, giddy, feeling of fullness in the head, weak, tired out, red tongue, few tongue, root is yellow is bored with thready and stringy pulse.The prostatic fluid chemical examination: erythrocyte (+), leukocyte (++), pus cell is a small amount of.Digital rectal examination: prostate hyperplasia, pain.Card belongs to deficiency in origin and excess in superficiality, and its void is at kidney, and the turbid damp of duty is made a bet in fact, controls that should the kidney invigorating to lead turbid be main.Medicinal: Radix Rehmanniae Preparata 10g, Herba Cynomorii 15g, Radix Astragali 10g, Rhizoma Corydalis 10g, Herba Epimedii 15g, Semen Cuscutae 15g, Herba Ecliptae 10g, Fructus Schisandrae Chinensis 10g, Herba Hedyotidis Diffusae 15g, Flos Carthami 10g, Radix Polygoni Multiflori Preparata 15g, Fructus Ligustri Lucidi 10g, Radix Salviae Miltiorrhizae 10g, Radix Paeoniae Alba 10g, Myrrha 10g, Spica Prunellae 15g, Fructus Cnidii 10g, Herba Patriniae 10g, Radix Scutellariae 10g, Radix Angelicae Sinensis 10g, Cortex Moutan 15g.Go up medicinal clear water and fry in shallow oil to 500ml, after filtering with antiseptic gauze, standby in the infusion bottle of packing into.Detailed directions: connect infusion bottle with tube for transfusion, its end connects aseptic catheter and paraffine oil, and with patient's buttocks bed hedgehopping, catheter inserts the about 15cm of rectum, and fluid temperature keeps 35～40 ℃, with 60～80/min speed, slowly splashes into.10 days is 1 course of treatment, and the interval is 5 days between the course of treatment, and after finished 3 courses of treatment, above-mentioned symptom was alleviated, and the check prostatic fluid is normal, clinical cure.

Specific embodiment 2: thank certain, the man, 36 years old, suffer from chronic prostatitis, prostate hyperplasia, symptom is thin for the urine line, dysuria, urethral orifice causalgia, and symptoms such as hyposexuality, sexual impotence are arranged, and has a strong impact on sleep.Poor effect undergoes various treatments.Prostatic fluid on inspection, 16/HP of leukocyte (high power field under the mirror) erythrocyte (-).Medicinal: Radix Rehmanniae Preparata 15g, Herba Cynomorii 10g, Radix Astragali 15g, Rhizoma Corydalis 10g, Herba Epimedii 10g, Semen Cuscutae 15g, Herba Ecliptae 10g, Fructus Schisandrae Chinensis 15g, Herba Hedyotidis Diffusae 10g, Flos Carthami 10g, Radix Polygoni Multiflori Preparata 15g, Fructus Ligustri Lucidi 10g, Radix Salviae Miltiorrhizae 10g, Radix Paeoniae Alba 10g, Myrrha 15g, Spica Prunellae 15g, Fructus Cnidii 10g, Herba Patriniae 10g, Radix Scutellariae 10g, Radix Angelicae Sinensis 10g, Cortex Moutan 10g.Take the remission in 15 days of the described tablet of the embodiment of the invention and alleviate, continuing to take 2 months pudendum again has nice and cool sensation, and lower abdomen does not expand, and moist phenomenon disappears, and physical recovery is normal, so far not recurrence.

Specific embodiment 3: Lee, the man, 49 years old, over nearly 1 year; dribbling urination not to the utmost, the no smooth susceptible of desire urine, night frequent micturition for very, the state of an illness was shown effect repeatedly for 5 years; and have that sexual function seriously descends, premature ejaculation is serious, and symptom such as fidgety, insomnia is arranged, and was chronic prostatitis and prostatic hyperplasia after diagnosing.The prostatic fluid chemical examination: erythrocyte (+), leukocyte (++), pus cell is a small amount of.Digital rectal examination: prostate hyperplasia, pain.Card belongs to deficiency in origin and excess in superficiality, and its void is at kidney, and the turbid damp of duty is made a bet in fact, controls that should the kidney invigorating to lead turbid be main.Medicinal: Radix Rehmanniae Preparata 10g, Herba Cynomorii 10g, Radix Astragali 15g, Rhizoma Corydalis 10g, Herba Epimedii 10g, Semen Cuscutae 15g, Herba Ecliptae 10g, Fructus Schisandrae Chinensis 15g, Herba Hedyotidis Diffusae 10g, Flos Carthami 10g, Radix Polygoni Multiflori Preparata 15g, Fructus Ligustri Lucidi 15g, Radix Salviae Miltiorrhizae 10g, Radix Paeoniae Alba 10g, Myrrha 10g, Spica Prunellae 15g, Fructus Cnidii 10g, Herba Patriniae 10g, Radix Scutellariae 10g, Radix Angelicae Sinensis 10g, Cortex Moutan 15g.Take the described honey refining pill of the embodiment of the invention after 20 days after the course of treatment, lower abdomen does not expand, and moist phenomenon disappears, and frequent micturition is improved, and continues to take 4 months, and above-mentioned symptom disappears, and physical recovery is normal, does not have recurrence so far.

Specific embodiment 4: blue certain, 28 years old, readme frequent micturition, urethral orifice causalgia, and symptoms such as hyposexuality, sexual impotence are arranged, adolescence masturbation is excessive.Check to find perineal position and lower abdomen dull pain discomfort, urinate back and normal after an action of the bowels adularescent secretions flow out from urethral orifice, sexual hypofunction, and feeling of fullness in the head, weak, tired out, red tongue, few tongue, root are yellow greasy, thready and stringy pulse.The prostatic fluid chemical examination: erythrocyte (+), leukocyte (++), pus cell is a small amount of.Digital rectal examination: prostate hyperplasia, pain.Card belongs to deficiency in origin and excess in superficiality, and its void is at kidney, and the turbid damp of duty is made a bet in fact, controls that should the kidney invigorating to lead turbid be main.Medicinal: Radix Rehmanniae Preparata 15g, Herba Cynomorii 15g, Radix Astragali 15g, Rhizoma Corydalis 10g, Herba Epimedii 10g, Semen Cuscutae 15g, Herba Ecliptae 10g, Fructus Schisandrae Chinensis 15g, Herba Hedyotidis Diffusae 15g, Flos Carthami 10g, Radix Polygoni Multiflori Preparata 15g, Fructus Ligustri Lucidi 15g, Radix Salviae Miltiorrhizae 10g, Radix Paeoniae Alba 10g, Myrrha 10g, Spica Prunellae 15g, Fructus Cnidii 10g, Herba Patriniae 10g, Radix Scutellariae 10g, Radix Angelicae Sinensis 10g, Cortex Moutan 15g.Take the described honey refining of embodiment of the invention pill after 15 days, frequent micturition is improved, and lower abdomen does not expand, and moist phenomenon disappears, and continues to take 2 months, and above-mentioned symptom disappears, and physical recovery is normal, does not have recurrence so far.

Claims

1. a Chinese medicine preparation for the treatment of chronic prostatitis is characterized in that, the ratio of weight and number of various crude drug is in the described Chinese medicine preparation: 10～20 parts of Radix Rehmanniae Preparata, 10～20 parts of Herba Cynomoriis, 10～20 parts of the Radixs Astragali, 10～20 parts of Rhizoma Corydalis, 10～20 parts of Herba Epimedii, 10～20 parts of Semen Cuscutae, 10～20 parts of Herba Ecliptaes, 10～20 parts of Fructus Schisandrae Chinensis, 10～20 parts of Herba Hedyotidis Diffusaes, 10～20 parts on Flos Carthami, 10～20 parts of Radix Polygoni Multiflori Preparata, 10～20 parts of Fructus Ligustri Lucidi, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of the Radix Paeoniae Albas, 10～20 parts of Myrrhas, 10～20 parts of Spica Prunellaes, 10～20 parts of Fructus Cnidiis, 10～20 parts of Herba Patriniae, 10～20 parts of Radix Scutellariaes, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Cortex Moutans.

2. according to the Chinese medicine preparation of the described treatment chronic prostatitis of claim 1, it is characterized in that the ratio of weight and number of various crude drug is in the described Chinese medicine preparation: 10～15 parts of Radix Rehmanniae Preparata, 10～15 parts of Herba Cynomoriis, 10～15 parts of the Radixs Astragali, 10～15 parts of Rhizoma Corydalis, 10～15 parts of Herba Epimedii, 10～15 parts of Semen Cuscutae, 10～15 parts of Herba Ecliptaes, 10～15 parts of Fructus Schisandrae Chinensis, 10～15 parts of Herba Hedyotidis Diffusaes, 10～15 parts on Flos Carthami, 10～15 parts of Radix Polygoni Multiflori Preparata, 10～20 parts of Fructus Ligustri Lucidi, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of the Radix Paeoniae Albas, 10～20 parts of Myrrhas, 10～20 parts of Spica Prunellaes, 10～20 parts of Fructus Cnidiis, 10～20 parts of Herba Patriniae, 10～20 parts of Radix Scutellariaes, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Cortex Moutans.

3. according to the Chinese medicine preparation of the described treatment chronic prostatitis of claim 1, it is characterized in that the ratio of weight and number of various crude drug is in the described Chinese medicine preparation: 10～20 parts of Radix Rehmanniae Preparata, 10～20 parts of Herba Cynomoriis, 10～20 parts of the Radixs Astragali, 10～20 parts of Rhizoma Corydalis, 10～20 parts of Herba Epimedii, 10～20 parts of Semen Cuscutae, 10～20 parts of Herba Ecliptaes, 10～20 parts of Fructus Schisandrae Chinensis, 10～20 parts of Herba Hedyotidis Diffusaes, 10～20 parts on Flos Carthami, 10～20 parts of Radix Polygoni Multiflori Preparata, 10～15 parts of Fructus Ligustri Lucidi, 10～15 parts of Radix Salviae Miltiorrhizaes, 10～15 parts of the Radix Paeoniae Albas, 10～15 parts of Myrrhas, 10～15 parts of Spica Prunellaes, 10～15 parts of Fructus Cnidiis, 10～15 parts of Herba Patriniae, 10～15 parts of Radix Scutellariaes, 10～15 parts of Radix Angelicae Sinensis, 10～15 parts of Cortex Moutans.

4. one kind as the preparation method of the Chinese medicine preparation of treatment chronic prostatitis as described in each in the claim 1～3, it is characterized in that the dosage form of described preparation is a tablet, and preparation method comprises:

A. described crude drug is mixed, chopping is soaked;

5. according to the described preparation method of claim 4, it is characterized in that, with soaked crude drug heating and refluxing extraction 2 times, each 1～2 hour, 2 extracting solution are merged leave standstill among the described step b.

6. according to claim 4 or 5 described preparation methoies, it is characterized in that among the described step c, 60～70% alcohol heating reflux that the medicinal residues that above-mentioned water extraction is crossed add 5～8 times of weight portions extract 2 times, each 1～2 hour, 2 extracting solution are merged leave standstill.

7. according to each described preparation method in the claim 4～6, it is characterized in that, in the described steps d, above-mentioned two kinds of extracting solution are merged the filtrate of relative density 1.35 when concentrating under reduced pressure is 80 ℃, reclaim ethanol, gained filtrate is adjusted proportion to 1.06, reduce pressure extractum, with CO 60 sterilizations, irradiation dose 8k adds starch or cane sugar powder and makes tablet.

8. one kind as the preparation method of the Chinese medicine preparation of treatment chronic prostatitis as described in each in the claim 1～3, it is characterized in that, the dosage form of described preparation is a honey refining pill, its preparation method comprises: earlier described crude drug is ground into coarse powder, further pulverize again, cross 120 mesh sieves, the fine powder amount that enable pass is crossed 120 mesh sieves is reaching 30%, and the fine powder of collecting by 120 mesh sieves gets fine powder a; Can not drop into multi-function extractor by the coarse powder of 120 mesh sieves again extracts twice: the decocting that adds 8-10 times of weight portion for the first time boiled 1-2 hour, and the decocting that adds 4-8 times of weight portion for the second time boiled 1-2 hour; Merge decocting liquid twice, filter, heating is concentrated into pasty state, puts into 80 ℃ of oven dry of baking oven postcooling, grinds to form fine powder b, with fine powder a with call in Mel after fine powder b mixes and make the sweet pill that refines.

9. one kind as the preparation method of the Chinese medicine preparation of treatment chronic prostatitis as described in each in the claim 1～3, it is characterized in that, the dosage form of described preparation is a rectally suppository, its preparation method comprises: with 50 ℃～60 ℃ heating and melting of substrate, add the fine powder a and the b that adopt the described preparation method preparation of claim 8, stirring in water bath is even, is mixed into heavy-gravity liquid, be poured in the plastics calibration tube, cooling and shaping is made class warhead shape suppository; Described substrate is selected from: one or more in semi-synthetic fatty acid glyceride, poloxamer, Polyethylene Glycol, the lanoline.

10. according to the Chinese medicine preparation of the described treatment chronic hepatitis B of claim 1～3, it is characterized in that the dosage form of described Chinese medicine preparation is: decocting enema, tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, pill, powder, sublimed preparation, solution, injection, suppository, plaster, syrup or suppository.