CN102058695B - Chinese medicine composition as well as preparation method and application thereof - Google Patents
Chinese medicine composition as well as preparation method and application thereof Download PDFInfo
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- CN102058695B CN102058695B CN2011100044379A CN201110004437A CN102058695B CN 102058695 B CN102058695 B CN 102058695B CN 2011100044379 A CN2011100044379 A CN 2011100044379A CN 201110004437 A CN201110004437 A CN 201110004437A CN 102058695 B CN102058695 B CN 102058695B
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- chinese medicine
- radix platycodonis
- medicine composition
- inflammation
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Abstract
The invention relates to a Chinese medicine composition for preventing or treating inflammation and a preparation method thereof. The composition comprises the following components in parts by weight: 0.5-1.5 parts of Chinese date, 3.5-10.5 parts of fructus cannabis and 1.5-4.5 parts of platycodon grandiflorum. The Chinese medicine composition can be used for improving the body resistance of a patient, preferably carrying out prevention on the patient in the initial stage of inflammation or probable infected people, not only can be used as a medicament for taking in the initial stage of inflammation but also can be used as a health-care product for improving the body resistance and preventing diseases.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition of medicine-food two-purpose, and the method for preparing of said composition and purposes, the Medicines and Health Product field belonged to.
Background technology
At present, along with a large amount of appearance of multidrug resistant disease substance (antibacterial, virus and former insects parasite), the research and development of antibiotics sink into again to pause, and make infectious disease become a clinical difficult problem again.Especially along with the aggravation of social senilization, the elderly population that immunity is low relatively is more so compromised, and the no medicine control in back takes place to infect, and then is tantamount to helplessly wait for death.Epidemiological study shows, have an appointment every year 400000 sepsis patient of the U.S., in case concurrent shock then mortality rate is higher than 50%, year death toll surpasses 100,000.In causing the suppurative pathogenic bacterium of nosocomial infection, staphylococcus aureus occupies the first place because of it distributes extensively, resistance is strong, be prone to drug resistance.The rising that gold Portugal bacterium infects and the drug resistance of bacterial strain form closely related, cause the treatment difficulty, and case fatality rate is high, becomes clinicist and scientific research personnel's a thorny difficult problem.In certain areas even occurred the so-called superbacteria staphylococcus aureus of vancomycin resistance (can) and cause patient to cure and dead incident.Therefore; The Chinese medicine therapy that can be used for preventing and treat this type infectious disease causes people's interest and attention just day by day; With the compound recipe of being made up of kinds of traditional Chinese medicines under the instruction of Chinese Medicine theory then is the basis of this therapy; Often have original curative effect advantage, improve, then be difficult for forming drug resistance etc. like the integral body of paying attention to body.
Designer of the present invention is engaged in infection Chinese medicine compound screening and assessment for many years, in our experience, the direct antibacterial action of Chinese medicine, Western medicine antibiotic relatively, generally a little less than.Therefore use the treatment by Chinese herbs bacterial infection, it is very important to choose the right moment, just only at the initial stage of infecting, and when fastbacteria quantity is also less in the patient body, the effect that the Chinese medicine competence exertion is effectively intervened.So Chinese medicine is more suitable for being used to infecting the bacterial infection complication that early treatment and prevention are caused by other diseases (operation, wound, flu etc.).Our viewpoint is for the patient that drug-fast bacteria infection possibly take place, can adopt Chinese medicine to carry out prophylactic treatment.Get into the intravital commitment of patient in fastbacteria, Chinese medicine can play a role and stop its propagation.The viewpoint of the attention prevention of this and the traditional Chinese medical science " on cure not treating the disease affected, and preventive treatment of disease " extremely conforms to.And consult existing document and open invention, and though the health promoting beverage of infection or the report of food are also arranged, mostly containing non-medicinal and edible Chinese medicine, the long-term drink safety can not get guaranteeing.
Summary of the invention
To above-mentioned deficiency, but the present invention provides a kind of Chinese medicine composition of medicine-food two-purpose, and said composition is made up of Fructus Jujubae, Radix Platycodonis, Fructus Cannabis.
Fructus Jujubae has invigorating the spleen and replenishing QI, and the effect of nourishing blood to tranquillize the mind can improve body immunity, selection is red with color, meat is thick, full, nuclear little, the flavor sweet person be good;
Fructus Cannabis has the effect of moisturizing the laxation relieving constipation, can promote bacteriotoxic discharge, and selection is good with yellow skin, no cot, full person;
Radix Platycodonis has lung qi dispersing, eliminates the phlegm, the effect of sore-throat relieving, evacuation of pus, has discharge of bacteria toxin expelling effect equally, and selection is loose with the root bar, color has a little little Huang in vain, and matter is solid, and section has graininess, Flos Chrysanthemi stricture of vagina person slightly for good.
The part by weight that is used between Fructus Jujubae of the present invention, Radix Platycodonis, the Fructus Cannabis is: Fructus Jujubae 0.5～1.5 weight portion, Fructus Cannabis 3.5～10.5 weight portions, Radix Platycodonis 1.5～4.5 weight portions.Further preferred Fructus Jujubae 0.5～1.0 weight portion, Fructus Cannabis 3.5～7 weight portions, Radix Platycodonis 1.5～3 weight portions.1 part of further preferred Fructus Jujubae weight, 7 parts of Fructus Cannabis weight, 3 parts of Radix Platycodonis weight.
The present invention further provides the method for preparing of this Chinese medicine composition:
Get Radix Platycodonis, add 10～20 times of water gagings, soaked 12～24 hours, during change water 2～3 times, filter, dry or be baked to absolutely dry, subsequent use; Fructus Cannabis, Fructus Jujubae add the Radix Platycodonis of handling through cleaning, drying, get product, and soaked drinking, each about 4～10 grams once a day, are taken the circumstances into consideration adjusting according to patient's body constitution and age.Secondly according to drinking custom, finished product of the present invention can further be ground into 40～80 purpose powder, packs the bag of making tea, every bag of 4～10g.
Chinese medicine composition of the present invention can be used for improving patient's Abwehrkraft des Koepers, preferably is in the patient at inflammation initial stage or the crowd of PI is prevented.Promptly can be used as medicine and take, also can be used as health product and be used to improve Abwehrkraft des Koepers, be used for prevent disease at the inflammation initial stage.
Advantage of the present invention:
(1) safety non-toxic of the present invention, inexpensive has practicality.The composition of said composition belongs to all that health ministry announces be food be again the Chinese medicine list of medicine, safety non-toxic is fit to take for a long time, and cheap and easy to get.This health-care effect reduces the antibiotic abuse to raising, the prevention PD of body resistance against diseases, practices thrift the medical fees of a large amount of costlinesses, and to alleviating national medical insurance burden, the arrival of reply aging society is significant.
(2) health care of the present invention is reliable.The present invention sets up screening model by computer earlier, and a large amount of infection Chinese medicine classic prescriptions are analyzed, and generates a large amount of compound recipes by computer then, and in conjunction with clinical experience, combination is estimated to medicinal and edible Chinese medicine, further verifies through zoopery again.Thereby health care of the present invention is reliable.
(3) suitable crowd is extensive.The present invention is especially suitable to the old age and the children population of pathogen susceptible; Can promote antibiotic substance regeneration in the body; Improve the ability that the anti-golden Portugal of body bacterium infects, the drug-resistant bacteria that also can be used for being caused by other diseases (operation, wound, flu etc.) infects the prophylactic treatment of complication.
The specific embodiment
Below in conjunction with embodiment the present invention is done further detailed, complete explanation, but the present invention is not limited in following embodiment.
Embodiment 1
Fructus Jujubae 0.5g
Fructus Cannabis 7g
Radix Platycodonis 3.5g
Get Radix Platycodonis, add 10 times of water gagings, soaked 24 hours, during change water 2～3 times, filter, dry or be baked to absolutely dry, subsequent use; Fructus Cannabis, Fructus Jujubae add the Radix Platycodonis of handling through cleaning, drying, are ground into 40 purpose powder, pack the bag of making tea, every bag of 5.5g.
Embodiment 2
Fructus Jujubae 1g
Fructus Cannabis 7g
Radix Platycodonis 3g
Get Radix Platycodonis, add 20 times of water gagings, soaked 12 hours, during change water 2～3 times, filter, dry or be baked to absolutely dry, subsequent use; Fructus Cannabis, Fructus Jujubae add the Radix Platycodonis of handling through cleaning, drying, are ground into 80 purpose powder, pack the bag of making tea, every bag of 5.5g.
Embodiment 3
Fructus Jujubae 1.5g
Fructus Cannabis 6g
Radix Platycodonis 3.5g
Get Radix Platycodonis, add 15 times of water gagings, soaked 20 hours, during change water 2～3 times, filter, dry or be baked to absolutely dry, subsequent use; Fructus Cannabis, Fructus Jujubae add the Radix Platycodonis of handling through cleaning, drying, are ground into 80 purpose powder, pack the bag of making tea, every bag of 5.5g.
Effect embodiment 1
The infection animal experiment study
One. do not take and cause the experiment that descends of its serum antibiotic substance behind the mouse infection gold Portugal bacterium of health tea
Set up golden Portugal bacterium infecting mouse group, this gold Portugal bacterium is the penicillin fastbacteria, the MIC value of benzylpenicillin is reached 250 μ g/mL, and sensitive organism generally is not more than 50ng/mL.Carry out lumbar injection gold Portugal bacterium the first day in test, matched group is not injected, and gathers serum after spending 4 days, and serum and the nutrient broth that contains golden Portugal bacterium are hatched jointly, measures bacterial number wherein after 18 hours, and the result is following:
Table 1 is injected the modeling mice of golden Portugal bacterium and is not injected the mice serum bacterial number comparison
of golden Portugal bacterium
| Group | Contain amount of bacteria in the blood serum medium (cfu/mL) |
| Do not inject golden Portugal bacterium mice matched group | (1.10±0.05)×10 7 |
| Inject golden Portugal bacterium mice group | (2.76±0.13)×10 7** |
Compare with matched group
*P＜0.01
The result shows, lumbar injection infects the mice serum culture fluid amount of bacteria (seeing table 1) that bacterial number in its serum culture fluid of mice of golden Portugal bacterium is not injected golden Portugal bacterium head and shoulders above.Point out the former antibacterial substance content and greatly reduce, the inhibition ability that is embodied in antibacterial reduces.
This experimental result prompting: after the infection of staphylococcus aureus mice; Antibacterial constantly breeds; Original antibiotic substance gets into the abdominal cavity in a large number and is consumed in the mice body; Surpass antibiotic substance regeneration speed in the body, thereby reduced the resistance of mice integral body to golden Portugal bacterium, the bacteriostasis that shows as the mice serum of the golden Portugal of injection bacterium is starkly lower than the mice of not injecting golden Portugal bacterium.Therefore, can reverse above-mentioned situation in early days, just become the key of anti-infective therapy at bacterial infection.
Two. health tea recovers the bacterium infecting mouse serum bacteriostasis experiment of golden Portugal
With health tea decocting liquid lumbar injection gold Portugal bacterium infecting mouse is irritated stomach (crude drug amount 2.2g/kg/d), normal saline is adopted in contrast, and the continuous irrigation stomach is put to death mice and gathered serum after 4 days, measure antibacterial power, and the result is following:
Table 2 health tea irritates stomach mice serum bacterial number and the normal saline matched group compares
| Group | Contain amount of bacteria in the blood serum medium (cfu/mL) |
| The normal saline matched group | (2.78±0.43)×10 7 |
| Health tea | (1.91±0.22)×10 7** |
Compare with matched group
*P＜0.01
The result shows that bacterial number obviously descends than normal saline group in the health tea filling stomach mice serum culture fluid, sees table 2, explains that its antibacterial power has obtained recovery.
Above-mentioned experimental result explanation: the patient takes this Chinese medicine composition, can promote antibiotic substance regeneration, effectively enhancing body anti-infection ability in the body.
Claims (4)
1. one kind is used to prevent or treat the Chinese medicine composition by the inflammation of staphylococcus aureus initiation; It is characterized in that; Said compositions is made up of Fructus Jujubae, Radix Platycodonis and Fructus Cannabis; Wherein the part by weight of Fructus Jujubae, Radix Platycodonis and Fructus Cannabis is: Fructus Jujubae 0.5～1.5 weight portion, Fructus Cannabis 3.5～10.5 weight portions, Radix Platycodonis 1.5～4.5 weight portions.
2. the described method for preparing that is used to prevent or treat the Chinese medicine composition of the inflammation that is caused by staphylococcus aureus of claim 1 is characterized in that, gets according to the following steps preparation: get Radix Platycodonis; Add 10～20 times of water gagings; Soaked 12～24 hours, during change water 2～3 times, filter; Dry or be baked to absolutely dry, subsequent use; Fructus Cannabis, Fructus Jujubae add the Radix Platycodonis of handling through cleaning, drying, get product, and soaked drinking, each 4～10 grams, once a day.
3. the described Chinese medicine composition of claim 1 is used for preventing or treating the purposes of the medicine of the inflammation that is caused by staphylococcus aureus in preparation.
4. purposes according to claim 3 is characterized in that its inflammation is to be caused by Resistant strain.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2011100044379A CN102058695B (en) | 2011-01-11 | 2011-01-11 | Chinese medicine composition as well as preparation method and application thereof |
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| CN2011100044379A CN102058695B (en) | 2011-01-11 | 2011-01-11 | Chinese medicine composition as well as preparation method and application thereof |
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| CN102058695A CN102058695A (en) | 2011-05-18 |
| CN102058695B true CN102058695B (en) | 2012-05-02 |
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| CN103585359B (en) * | 2013-11-11 | 2017-10-27 | 北京博爱旺康医药科技有限公司 | It is a kind of to treat Chinese medicine composition of inflammation and its preparation method and application |
| CN108542964A (en) * | 2018-06-28 | 2018-09-18 | 重庆市中药研究院 | It is a kind of improve immunity medicine to composition of medicine and its preparation method and application |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1278443A (en) * | 1999-06-17 | 2001-01-03 | 云南金碧制药厂 | Medicine for treating disease of upper respiratory tract and its preparation |
| CN1380098A (en) * | 2002-05-20 | 2002-11-20 | 张勇飞 | Anti-infection compound preparation and its preparation method |
| CN1827126A (en) * | 2005-03-01 | 2006-09-06 | 重庆大易科技投资有限公司 | Chinese medicinal composition for treating viral infection of upper respiratory tract and preparing process thereof |
| CN101049424A (en) * | 2006-04-03 | 2007-10-10 | 湖南中达骛马制药有限责任公司 | Medication for treating infection in respiratory system |
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2011
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1278443A (en) * | 1999-06-17 | 2001-01-03 | 云南金碧制药厂 | Medicine for treating disease of upper respiratory tract and its preparation |
| CN1380098A (en) * | 2002-05-20 | 2002-11-20 | 张勇飞 | Anti-infection compound preparation and its preparation method |
| CN1827126A (en) * | 2005-03-01 | 2006-09-06 | 重庆大易科技投资有限公司 | Chinese medicinal composition for treating viral infection of upper respiratory tract and preparing process thereof |
| CN101049424A (en) * | 2006-04-03 | 2007-10-10 | 湖南中达骛马制药有限责任公司 | Medication for treating infection in respiratory system |
Non-Patent Citations (4)
| Title |
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| 张玲玲等.几种中药有效部位抗炎作用的比较.《安徽医科大学学报》.2002,第37卷(第06期),全文. * |
| 陈汐等.中药抗炎6号注射液对大鼠腹腔巨噬细胞氧化爆发的影响.《中国病理生理杂志》.1988,第04卷(第04期),全文. * |
| 陈雨姣.从现代免疫学角度探讨中医中药抗感染作用.《江西中医学院学报》.2002,第14卷(第04期),全文. * |
| 黄锋等.中药抗炎免疫药理研究进展.《新乡医学院学报》.2002,第19卷(第04期),全文. * |
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