CN102048884B - Weight-losing composition containing guarana extract - Google Patents
Weight-losing composition containing guarana extract Download PDFInfo
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- CN102048884B CN102048884B CN 201010608084 CN201010608084A CN102048884B CN 102048884 B CN102048884 B CN 102048884B CN 201010608084 CN201010608084 CN 201010608084 CN 201010608084 A CN201010608084 A CN 201010608084A CN 102048884 B CN102048884 B CN 102048884B
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Abstract
The invention provides a weight-losing composition which comprises L-carnitine or a pharmaceutically acceptable salt of the L-carnitine and a guarana extract, and the invention simultaneously provides a formulation of the weight-losing composition and a preparation method thereof. The weight-losing composition can accelerate the burning of fat in a human body, and effectively oxidize, decompose and convert the fat in the human body to energy, thereby achieving the purpose of naturally controlling and reducing the body weight.
Description
Technical field
The present invention relates to a kind of health promoting product, be specifically related to a kind of Weight reducing compound of L-carnitine or its pharmaceutically acceptable salt and Guarana extract and preparation method of preparation and preparation thereof of containing.
Background technology
Along with the gradually raising of people's living standard, food type and food supply be very abundant all.The diet that be in easy circumstances, allegro life causes is irregular, lacks motion etc., so that the absorption of body self-energy is greater than consumption, and athero, adipose cell increases, and the fat of health surpasses normal level, thereby causes obesity.Obesity is a kind of metabolic chronic disease, can cause various diseases by obesity, such as hypertension, and hyperlipidemia, diabetes, coronary heart disease etc.These diseases health of engulfing the people just gradually all brought great impact for work and life, and the fat number of China is increasing with surprising rapidity, and problem of obesity can not be ignored.
At present, all kinds of diet food on the market are multifarious, food, medicine, health product etc.Most products or be to take appetite-suppressing, or be that the method such as take to suffer from diarrhoea reaches the purpose of fat-reducing.Though some produces effect, also exist very large side effect, be a kind of infringement to the health of health.
L-carnitine (L-carnitine) claims again VBT, DL-carnitine chloride, and chemical name is beta-hydroxy γ-trimethylamine butanoic acid, is a kind of white crystalline lens or white transparent fine powder.L-carnitine is the moisture absorption very easily, and stable good can place in the solution of pH 3～6 more than 1 year, ability more than 200 ℃ high temperature and have preferably solubization and water absorption.L-carnitine has been applied to the fields such as medicine, health care and food at present.
Carnitine is that a kind of fat that promotes is converted into the amino acid of energy, and red meat is the main source of L-carnitine, and human body is had no side effect.Dissimilar diets has contained the L-carnitine of 5-100 milligram, but common people can only take in 50 milligrams every day from meals, and vegetarian is taken in still less.The main Physiological Function of L-carnitine is to promote that fat changes into energy, taking L-carnitine can be when reducing body fat, reducing body weight, do not reduce moisture and muscle, regarded as the safest fat-reducing nutrient complementary goods that has no side effect in 2003 by international fat health tissues.
Guarana (Guarana) is a kind of wild certain kind of berries of Amazon area special product, is heat energy combustion fat supplement, includes natural Caffeine, vitamin, unsaponifiable matter and tannin, and abundant alkaloid, tannin, protein etc.The caffeine that Guarana seed and root contain can keep the human body mental status, is specially adapted to deal with modern society's life, studies show that, the excited people's of a small amount of caffeine energy nerve, have the effect of burning body fat, make the people keep the good mental status, therefore have the effect of fat-reducing.
Chinese patent 98807193.2, " alimentation composition that is used in tension patient " disclose a kind of alimentation composition, by (a) VBT or a kind of alkanoyl L-carnitine or a kind of their acceptable salt on the pharmacology; (b) mixture of natural plant extracts (for example Yohimbine and Guarana); (c) soybean lecithin; And (d) malic acid forms, and said composition can be used for because anxiety is in the patient of weak state.The purposes that is not used for fat-reducing.
The invention provides a kind of Weight reducing compound, by accelerating the burning of fat in the health, can effectively make the body fat oxidation Decomposition be converted into energy, thereby reach the purpose of nature control and attenuating body weight.
Summary of the invention
The purpose of this invention is to provide a kind of burning that can accelerate fat in the health, effectively make the body fat oxidation Decomposition be converted into energy, thereby reach the Weight reducing compound of nature control and attenuating body weight purpose.
The present invention also provides the preparation of this Weight reducing compound.
The present invention also provides the preparation method of the preparation of this Weight reducing compound.
A kind of Weight reducing compound provided by the invention is comprised of L-carnitine or its pharmaceutically acceptable salt and Guarana extract.
A kind of Weight reducing compound provided by the invention is comprised of the raw material of following weight portion: 500～5000 parts of L-carnitine or its pharmaceutically acceptable salts, 50～500 parts of Guarana extracts.
Weight reducing compound provided by the invention, further preferred, said composition is comprised of the raw material of following weight portion: 50～200 parts of L-carnitine or its pharmaceutically acceptable salt 1000-3000 part, Guarana extracts.
Wherein:
Described parts by weight can be the known unit of weights of field of medicaments such as μ g, mg, g, kg.
The salt of described pharmaceutically acceptable L-carnitine is selected from one or more in L-carnitine-L-tartrate, Carnitine Fumarate or the L-carnitine hydrochloride.
Described Guarana extracts system and extracts from the Guarana bean (Guarana) that Brazil produces, and the natural caffeine that it mainly contains 10% has refresh oneself excited and slight antiobesity action.
The present invention also provides the preparation of this Weight reducing compound, is comprised of Weight reducing compound and pharmaceutically acceptable carrier or diluent.
The present invention also provides the preparation of this Weight reducing compound, is comprised of Weight reducing compound and the pharmaceutically acceptable carrier of 100-2000 weight portion or diluent.
The preparation of Weight reducing compound of the present invention can be solid preparation or liquid preparation, and solid preparation is selected from tablet, pill, capsule, soft capsule or granule; Liquid preparation is oral liquid.
Described pharmaceutically acceptable carrier or diluent are selected from one or more in xylitol, Sorbitol, hydroxyl isomaltulose, isomaltulose, mannitol, ethanol, microcrystalline Cellulose, lactose, hydroxypropyl methylcellulose, sodium carboxymethyl cellulose or the magnesium stearate.
The present invention also provides the preparation technology of the preparation of this Weight reducing compound, may further comprise the steps: take by weighing L-carnitine or its pharmaceutically acceptable salt, Guarana extract raw material, sieve mixing, then add pharmaceutically acceptable carrier or diluent, make various dosage forms.
Preparation compositions of the present invention has following beneficial effect:
Compositions for fat-reducing of the present invention, prescription carries out L-carnitine or its pharmaceutically acceptable salt, Guarana extract composite in specific proportions, and wherein, L-carnitine is the fatty acid oxidation carrier, fat can be transferred to mitochondrion, in mitochondrion, carry out oxidizing fire; The Guarana extract increases rate of metabolism, can increase energy expenditure and stimulate steatolysis, and two medicine proportionings can significantly increase fat-reducing effect, have synergistic function.
The specific embodiment
Following examples are used for explanation the present invention, but are not used for limiting the scope of the invention.
Buying producer for L-carnitine and Guarana extract is in order to further specify realizability of the present invention, still should not to be used for limiting the scope of the invention.
Raw material L-carnitine of the present invention is available from Shenyang Keshuo Nutrition Technology Co., Ltd.; The Guarana extract contains 10% natural caffeine available from the illustrious and influential International Trading Company Ltd in Dalian.
Embodiment 1: capsule
1, prescription: L-carnitine-L-tartrate 5000g, Guarana extract 500g, microcrystalline Cellulose 500g, magnesium stearate 50g
2, preparation technology
1) take by weighing L-carnitine-L-tartrate, Guarana extract according to prescription and cross respectively 40 mesh sieves, for subsequent use;
2) take by weighing microcrystalline Cellulose and magnesium stearate according to prescription, above-mentioned supplementary material by the equivalent method mix homogeneously that progressively increases, is poured in the capsule-filling mould, the fill capsule, polishing, packing, and get final product.
3, specification: every contains L-carnitine 0.3g, Guarana extract 0.03g.
Embodiment 2: granule
1, prescription: L-carnitine 500g, Guarana extract 100g, hydroxyl isomaltulose 1000g
2, preparation technology
1) take by weighing L-carnitine, Guarana extract according to prescription, cross respectively 40 mesh sieves, for subsequent use;
2) take by weighing hydroxyl isomaltulose according to prescription; with above-mentioned supplementary material by the equivalent method mix homogeneously that progressively increases; use 50% ethanol as binding agent, soft material processed is with above-mentioned soft material granulation in the oscillating granulator of 14 eye mesh screens; granule is inserted in the multi-functional boiling drier; about 40 minutes of 50 ℃ of airpillow-dry, control pellet moisture be 5%, then granulate; packing, and get final product.
3, specification: every contains L-carnitine 0.3g, Guarana extract 0.06g.
Embodiment 3: tablet
1, prescription: Carnitine Fumarate 1000g, Guarana extract 50g, hydroxyl isomaltulose 1000g, lactose 500g, magnesium stearate 20g;
2, preparation technology
1) take by weighing Carnitine Fumarate, Guarana extract according to prescription, cross respectively 40 mesh sieves, for subsequent use;
2) take by weighing hydroxyl isomaltulose, lactose according to recipe quantity, by the equivalent method mix homogeneously that progressively increases, use 50% ethanol as binding agent above-mentioned supplementary material; soft material processed with above-mentioned soft material granulation in the oscillating granulator of 14 eye mesh screens, is inserted granule in the multi-functional boiling drier; about 40 minutes of 50 ℃ of airpillow-dry, control pellet moisture be 5%, granulate; then in granule, add magnesium stearate 20g; mix homogeneously, tabletting, film coating; packing, and get final product.
3, specification: every contains L-carnitine 0.3g, Guarana extract 0.015g.
Embodiment 4: pill
1, prescription: L-carnitine 3000g, Guarana extract 200g, hydroxyl isomaltulose 1800g, sodium carboxymethyl cellulose are an amount of.
2, preparation technology
1) take by weighing L-carnitine, Guarana extract according to prescription, cross respectively 40 mesh sieves, for subsequent use;
2) take by weighing hydroxyl isomaltulose according to prescription, according to the equivalent method mix homogeneously that progressively increases, use the aqueous solution of 0.8% sodium carboxymethyl cellulose as binding agent above-mentioned supplementary material, soft material processed is put into the pellet processing machine pill with above-mentioned soft material, oven dry, packing behind the whole ball, and get final product.
3, specification: every ball contains L-carnitine 0.3g, Guarana extract 0.02g.
Embodiment 5: tablet
1, prescription: L-carnitine hydrochloride 1500g, Guarana extract 150g, hydroxyl isomaltulose 1000g, lactose 500g, mannitol 300g, magnesium stearate 30g.
2, preparation technology's reference example 3, make 5000.
3, specification: every contains left-handed 0.3g, Guarana extract 0.03g.
Experimental example 1 human experimentation
1, experimental subject and method
1.1 experimental subject
This is tested whole experimenters and carries out respectively constitutional index assessment be obese people, male 30 examples among the 60 routine experimenters, women 30 examples before experiment; Age is between 18-45 year, year mean age (30.7 ± 6.5).
1.2 experimental technique
Grouping: 60 experimenters are divided into six groups at random, negative control group (N=10), positive control one group of (N=10), positive control two groups of (N=10), experiment one group of (N=10), experiment two groups of (N=10) and three groups (N=10) of experiment.Negative control group is taken placebo, 4/day; One group of positive control is taken the L-carnitine capsule, 4/day (every contains L-carnitine 0.6g); Two groups of positive controls are taken the Guarana extract, 4/day (every contains Guarana extract 0.12g), test one group and take Weight reducing compound tablet group of the present invention, 4/day (with reference to the method preparation of embodiment 5, every contains L-carnitine 0.3g and Guarana extract 0.03g); Test two groups and take Weight reducing compound of the present invention, 4/day (with reference to the method preparation of embodiment 2, every contains L-carnitine 0.3g and Guarana extract 0.06g); Test three groups and take 4/day of Weight reducing compounds of the present invention (with reference to the method preparation of embodiment 3, every contains L-carnitine 0.3g and Guarana extract 0.015g).Took continuously for 8 weeks according to the method described above.Whole experimental session is not kept on a diet, and deliberately do not increase motion, and taboo takes other diet food and medicine.
1.3 test index
1.3.1 body composition test: adopt weekly the body weight of DX200 super strong type body composition test instrument test subject, body fat percentage, body-mass index before the experiment and after the experiment.
1.4 data statistics
The data obtained is processed with Excel, adopts single blind method and t check that test data is carried out statistical analysis, represents with mean ± SD.
2, experimental result and analysis
2.1 body composition analysis result
2.1.1 subject re-detection result before and after the experiment
Table 1: experimenter's body weight situation of change before and after the experiment
With take before compare,
*P＜0.05,
*P＜0.01; Compare with one group of positive control,
#P＜0.05; Compare with two groups of positive controls,
﹠amp;P＜0.05.
As can be seen from Table 1, compare with the body weight before the experiment, two groups of negative control group, one group of positive control, two groups of positive controls, one group of experiment, experiments with test three groups of experiments after body weight different reductions is all arranged, two groups of body weight of one group of positive control and positive control significantly descend (P＜0.05); Test one group, two groups of experiments and test three groups body weight extremely significantly descend (P＜0.01).
Compare with one group of positive control, test one group, two groups, three groups weight loss obvious (P＜0.05);
Compare with two groups of positive controls, test one group, the weight loss of two groups of experiments, three groups of experiments obviously (P＜0.05).
2.1.2 body fat percentage testing result before and after the experiment
Table 2: experimenter's body fat percentage testing result
With take before compare,
*P＜0.05,
*P＜0.01; Compare with one group of positive control,
#P＜0.05; Compare with two groups of positive controls,
﹠amp;P＜0.05.
As can be seen from Table 2, compare with the body fat percentage before the experiment, two groups of negative control group, one group of positive control, two groups of positive controls, one group of experiment, experiments with test three groups of experiments after body fat percentages different reductions is all arranged, two groups of body fat percentages of one group of positive control and positive control significantly descend (P＜0.05); Test one group, two groups of experiments and test three groups body fat percentage extremely significantly descend (P＜0.01).
Compare with one group of positive control, test one group, two groups, three groups body fat decline obvious (P＜0.05);
Compare with two groups of positive controls, test one group, the body fat of two groups of experiments, three groups of experiments descend obviously (P＜0.05).
3, conclusion
Weight reducing compound of the present invention can accelerate body metabolism, and the ability of raising calory burning, in the situation of not keeping on a diet with deliberately motion, can accelerate the utilization of fat, in this experiment, experimental group is compared with two groups with one group of contrast, the amplitude of losing weight is greater than one group of positive control, two groups and negative control group, body fat percentage is significance and descends, illustrate that the experimenter takes Weight reducing compound of the present invention at the slimming fat that reduces simultaneously, body fat percentage descends, and then reaches the purpose of fat-reducing, has synergistic function.
Although, above used general explanation, the specific embodiment and test, the present invention is described in detail, on basis of the present invention, can make some modifications or improvements it, and this will be apparent to those skilled in the art.Therefore, these modifications or improvements all belong to the scope of protection of present invention without departing from theon the basis of the spirit of the present invention.
Claims (8)
1. Weight reducing compound, it is characterized in that, said composition is comprised of the raw material of following weight portion: 500 ~ 5000 parts of L-carnitine or its pharmaceutically acceptable salts, 20 ~ 500 parts of Guarana extracts, described Guarana extracts system and extracts from the Guarana bean that Brazil produces, and contains 10% natural caffeine.
2. Weight reducing compound according to claim 1 is characterized in that, said composition is comprised of the raw material of following weight portion: L-carnitine or its pharmaceutically acceptable salt 1000-3000 part, Guarana extract 50-200 part.
3. Weight reducing compound according to claim 1 and 2 is characterized in that, the salt of described pharmaceutically acceptable L-carnitine is selected from one or more in L-carnitine-L-tartrate, Carnitine Fumarate or the L-carnitine hydrochloride.
4. the preparation of Weight reducing compound according to claim 1 and 2 is comprised of Weight reducing compound and pharmaceutically acceptable carrier or diluent.
5. the preparation of Weight reducing compound according to claim 4 is characterized in that, described preparation is solid preparation or liquid preparation.
6. the preparation of Weight reducing compound according to claim 5 is characterized in that described solid preparation is selected from tablet, pill, capsule or granule; Liquid preparation is oral liquid.
7. the preparation of Weight reducing compound according to claim 4, it is characterized in that described pharmaceutically acceptable carrier or diluent are selected from one or more in xylitol, Sorbitol, hydroxyl isomaltulose, isomaltulose, mannitol, ethanol, microcrystalline Cellulose, lactose, hydroxypropyl methylcellulose, sodium carboxymethyl cellulose or the magnesium stearate.
8. method for preparing the preparation of Weight reducing compound claimed in claim 4, it is characterized in that: take by weighing L-carnitine or its pharmaceutically acceptable salt, Guarana extract raw material, sieve, add pharmaceutically acceptable carrier or diluent, mix homogeneously is prepared into various dosage forms.
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| CN102907623B (en) * | 2012-09-26 | 2014-05-28 | 北京康比特体育科技股份有限公司 | Pudding powder for losing weight and preparation method thereof |
| CN103404827B (en) * | 2013-07-08 | 2014-12-10 | 北京康比特体育科技股份有限公司 | Seasoning capable of loosing weight |
| CN103948044A (en) * | 2014-04-22 | 2014-07-30 | 江西日盛生物科技有限公司 | L-carnitine capsule |
| CN105725191A (en) * | 2016-02-16 | 2016-07-06 | 江苏隆力奇生物科技股份有限公司 | Composition having face-beautifying and weight-losing effects and preparation method and application thereof |
| CN109394745A (en) * | 2017-08-17 | 2019-03-01 | 博瑞生物医药（苏州）股份有限公司 | A kind of composition comprising L-carnitine and beta-hydroxy-butanoic acid compound |
| CN113170890B (en) * | 2021-05-25 | 2022-11-29 | 北京澳特舒尔保健品开发有限公司 | Fat-reducing and sugar-resisting health food composition and preparation method thereof |
| CN115969045A (en) * | 2021-10-14 | 2023-04-18 | 南京盛德生物科技研究院有限公司 | Composition with weight health management function and preparation method and application thereof |
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