CN102028737B

CN102028737B - Drug for treating coronary heart disease

Info

Publication number: CN102028737B
Application number: CN2009100706771A
Authority: CN
Inventors: 刘顺航; 徐波; 戚可人; 刘岩; 陈红; 丛德刚; 赵国辉
Original assignee: TIANJIN TASLY MODERN CHINESE MEDICINE RESOURCE CO Ltd
Current assignee: TIANJIN TASLY MODERN CHINESE MEDICINE RESOURCE CO Ltd
Priority date: 2009-09-29
Filing date: 2009-09-29
Publication date: 2013-12-11
Anticipated expiration: 2029-09-29
Also published as: CN102028737A

Abstract

The invention relates to a drug for treating coronary heart disease and a preparation method thereof. The preparation method comprises the following steps: extracting salvia with alcohol, extracting notoginseng with water and the like. The invention has the following advantages: the process route can realize industrialization and the quality is stable and controllable. Relevant experiments show that the drug has the advantages of high curative effect and product purity, good absorbability, stable quality and novel application compared with the prior art, and meanwhile, the preparation method is simple in process, convenient to operate, low in cost and suitable for industrial production.

Description

A kind of medicine for the treatment of coronary heart disease

Technical field

The present invention relates to a kind of medicine for the treatment of coronary heart disease, belong to the field of Chinese medicines.

Background technology

Along with the rejuvenation of growth in the living standard, world population aging and morbidity colony, Patients with geriatric cardiovascular and cerebrovascular diseases increases year by year, has become the second largest disease of harm humans health.Angina pectoris is a kind of caused by the temporary transient ischemia of cardiac muscle, anoxia, take the clinical syndrome that ictal chest pain or chest discomfort be main manifestations.Angina pectoris refers to because coronary atherosclerosis or spasm cause myocardial ischemia, the caused angina pectoris of anoxia, accounts for 90% of patient with angina pectoris.

The anginal method for the treatment of be take blood vessel dilating, reduction blood viscosity, anti-platelet aggregation, anticoagulation as main at present.Traditional Western medicine of application is nitrate, nitrous acid ester, beta-blocker, calcium antagonist etc., but all has larger toxic and side effects, unsuitable long-term taking, mostly be symptomatic treatment and to course advancement without larger effect.For example take after nitroglycerin occur sometimes beating in feeling of fullness in the head, head, palpitating speed, even faint [referring to 264 pages of new pharmacologies (the 14th edition)], find that there is again in recent years and cause severe hypotension [referring to contemporary Chinese medical journal 1997; 7 (4): 42; Shaanxi medical journal 1996; 25 (5): 315], easily produce toleration [referring to southern nursing magazine 1996; 3 (5): 7～9] etc. problem, hindered its application clinically.

Although the anginal Chinese patent medicine of many treatments is also arranged, wherein ball, loose, cream, pellet, decoction become ancient history already, and the modern seldom applies.There are in the market the preparations such as common FUFANG DANSHEN PIAN and capsule to sell, but conventional tablet, capsule manufacture technique fall behind, active constituent content is low, without quality control index, need oral through gastrointestinal absorption, absorbed into serum after liver generation first pass effect, bioavailability is low, absorbs slow. can not be applicable to the need of the first aid of Patients With Angina Pectoris.

Drop pill is fast, the eutherapeutic therapeutic drug of coronary heart disease of a kind of special effect, deeply is subject to clinically patient's welcome.In order to improve the preparation technology of current compound red sage root preparation, the inventor conducts in-depth research from the extraction process aspect, from saving the herb resource aspect, has improved product yield, the comprehensive utilization ratio of the contained effective ingredient of medical material.

Summary of the invention

The invention provides a kind of medicine for the treatment of coronary heart disease.

The medicine for the treatment of coronary heart disease of the present invention, described medicine is prepared from by the crude drug of following percentage by weight, Radix Salviae Miltiorrhizae 19.8%-97%, Radix Notoginseng 2%-80%, Borneolum Syntheticum 0.2%-3%, described preparation is first crude drug to be prepared into to active constituents of medicine through following steps, more further is prepared into medicine.

Step 1, Radix Salviae Miltiorrhizae adds alcohol, extracts, and extracting solution is concentrated, dry, obtains the tanshinol extract;

Step 2, the Radix Salviae Miltiorrhizae decoction dregs after step 1 alcohol extraction and Radix Notoginseng, aqueous alkali is or/and water extraction, and extracting solution is concentrated, adds alcohol, and standing, supernatant concentration, obtain the Salvia miltiorrhiza and Panax notoginseng extract;

Step 3, the tanshinol extract of step 1, the Salvia miltiorrhiza and Panax notoginseng extract of step 2 as active constituents of medicine, is further made medicine with adjuvant together with Borneolum Syntheticum.

Medicine of the present invention is for oral medicine, its preparation adopts the preparation of galenic pharmacy routine techniques, comprise the step that active constituents of medicine is mixed with the adjuvant of oral drugs, wherein the adjuvant of oral drug preparation is selected from starch, amylum pregelatinisatum, dextrin, Icing Sugar, lactose, mannitol, calcium sulfate two water things, calcium hydrogen phosphate, magnesium oxide, calcium carbonate, magnesium carbonate, water, ethanol, starch slurry, syrup, liquid glucose, maltose, refined honey, cane sugar powder, citric acid, essence, mucialga of arabic gummy, gelatine size, polyvinylpyrrolidone (PVP), rubber cement, microcrystalline Cellulose, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose, magnesium stearate, stearic acid, zinc stearate, calcium stearate, Pulvis Talci, Macrogol 4000, polyethylene glycol 6000, micropowder silica gel, vegetable oil, sodium stearate, glycerin gelatine, stearic acid, glyceryl monostearate, insect wax, one or several combinations of hydrogenated oil and fat.

Oral formulations of the present invention is selected from: all acceptable dosage forms on tablet, dispersible tablet, hard capsule, soft capsule, granule, pill, micropill, powder, drop pill, slow releasing preparation, controlled release preparation, syrup, oral liquid, soft extract and extractum pharmaceutics.

Its preferred preparation method of medicine that confession of the present invention is oral, step is:

Step 1, Radix Salviae Miltiorrhizae adds methanol, ethanol, normal propyl alcohol, isopropyl alcohol, n-butyl alcohol or the isobutanol of 2-12 times of 70-100%, and reflux, extract, is filtered, and extracting solution concentrating under reduced pressure, drying, obtain the tanshinol extract;

Step 2, the Radix Salviae Miltiorrhizae decoction dregs after the alcohol extraction of step 1, add Radix Notoginseng, the aqueous alkali that adds 2-12 times of pH value 7-10, extract 1-3 time, then add 2-12 times of water, extract 1-3 time, filter, filtrate is concentrated, adds ethanol to medicinal liquid and measures 50-80% containing alcohol, standing, separation of supernatant, reclaim ethanol, receive cream to pol 50%-90% or concentrated, dry, pulverizing, obtains the Salvia miltiorrhiza and Panax notoginseng extract;

Step 3, by the tanshinol extract of step 1, the Salvia miltiorrhiza and Panax notoginseng extract mixes with adjuvant with Borneolum Syntheticum, adds any or more than one adjuvants, and the 1-6 that the adjuvant addition is active component doubly, makes any oral formulations.

The preferred drop pill of medicine of the present invention, its preparation adopts the preparation of galenic pharmacy routine techniques, comprises the step that active constituents of medicine is mixed with the adjuvant of drop pill medicine, and described adjuvant is selected from fat-soluble substrate and water-soluble base, and the auxiliary ratio of medicine is 1: 1-6.Wherein said fat-soluble substrate is selected from: stearic acid, glyceryl monostearate, insect wax, Cera Flava, paraffin, hydrogenated vegetable oil, semi-synthetic fatty acid ester; Water-soluble base is selected from Polyethylene Glycol, polyoxyethylene monostearate, poloxamer, sodium stearate, glycerin gelatine etc.; Xylitol and composites of starch, erythritol; Preferably the auxiliary ratio of medicine is 1: 1.9.

The preferred preparation method of drop pill of the present invention, step is:

Step 1, Radix Salviae Miltiorrhizae adds 2-5 times of 70-100% ethanol, reflux, extract, 1-3 time, each 1-3 hour, filter, and extracting solution concentrating under reduced pressure, drying, obtain the tanshinol extract;

Step 2, Radix Salviae Miltiorrhizae decoction dregs after the ethanol extraction of step 1, add Radix Notoginseng to extract, and the aqueous alkali that adds for the first time 2-12 doubly to measure PH7-8 decocts 1-3 hour, add for the second time 2-12 times of water gaging to decoct 0.5-2 hour, obtain extracting solution, extracting solution is concentrated, adds ethanol to medicinal liquid and measures 50%-80% containing alcohol, standing 12-36 hour, separation of supernatant, reclaim ethanol, receive cream to pol 55%-80%, obtains the Salvia miltiorrhiza and Panax notoginseng extract;

Step 3, the tanshinol extract of step 1 is suspended in the PEG-6000 of pre-thawing; Add the Salvia miltiorrhiza and Panax notoginseng extract, mix homogeneously; Add Borneolum Syntheticum, mix; The material temperature is 60-100 ℃; The temperature of liquid paraffin is 5-10 ℃, makes drop pill.

Step 1, Radix Salviae Miltiorrhizae adds 2-5 and doubly measures 95% ethanol, reflux, extract, 1-3 time, each 1-3 hour, filter, and extracting solution concentrating under reduced pressure, drying, obtain Radix Salviae Miltiorrhizae 95% ethanol extract;

Step 2, Radix Salviae Miltiorrhizae decoction dregs after the ethanol extraction of step 1, add Radix Notoginseng, and the aqueous alkali that adds for the first time 6-12 doubly to measure PH7-8 decocts 1-3 hour, add for the second time 6-12 times of water gaging to decoct 0.5-2 hour, obtain extracting solution, extracting solution is concentrated, adds ethanol to medicinal liquid and measures 50%-75% containing alcohol, standing more than 12 hours, separation of supernatant, reclaim ethanol, receive cream to pol 55%-75%, obtains the Salvia miltiorrhiza and Panax notoginseng extract;

Step 3, Radix Salviae Miltiorrhizae 95% ethanol extract of step 1 is suspended in the PEG-4000 of pre-thawing; Add Salvia miltiorrhiza and Panax notoginseng extractum, mix homogeneously; Add Borneolum Syntheticum, mix; The material temperature is 60-100 ℃; The temperature of liquid paraffin is 5-10 ℃, makes drop pill.

The particularly preferred preparation method of drop pill of the present invention, step is:

Step 1, Radix Salviae Miltiorrhizae adds 2-3 and doubly measures 95% ethanol, reflux, extract, 2 times, each 1-2 hour, filter, and extracting solution concentrating under reduced pressure, drying, obtain Radix Salviae Miltiorrhizae 95% ethanol extract;

Step 2, Radix Salviae Miltiorrhizae decoction dregs after the ethanol extraction of step 1, add Radix Notoginseng, and the aqueous alkali that adds for the first time 6-12 doubly to measure PH7-8 decocts 1-3 hour, add for the second time 8 times of water gagings to decoct 1 hour, obtain extracting solution, extracting solution is concentrated, adds ethanol to medicinal liquid and measures 60%-70% containing alcohol, standing more than 12 hours, separation of supernatant, reclaim ethanol, receive cream to pol 70%-75%, obtains the Salvia miltiorrhiza and Panax notoginseng extract;

The present invention also comprises the application of medicinal dropping ball in the medicine of the cardiovascular disease such as a kind of resisting coronary heart disease of preparation, angina pectoris by treatment coronary heart disease of the present invention.

The present invention is more more superior than prior art because the change of technique causes the present invention to treat the medicinal dropping ball of coronary heart disease.

Below data declaration the present invention treats the beneficial effect of the medicinal dropping ball of coronary heart disease by experiment.

The medicinal dropping ball that adds treatment coronary heart disease of the present invention before Myocytes Anoxia, the intracellular calcium fluorescence intensity obviously descends, and proves that the medicinal dropping ball for the treatment of coronary heart disease has antagonism myocardial cell calcium overload, the effect of protecting myocardial cell.

After myocardial ischemia-reperfusion, in tissue, high-energy phosphate compound obviously reduces, and the lipid peroxide contents showed increased, cause reperfusion injury.Add the medicinal dropping ball for the treatment of coronary heart disease during pre-perfusion and during postischemic reperfusion before ischemia, in tissue, high-energy phosphate compound is all higher than ischemic reperfusion notes group, two groups of adenosine triphosphate (ATP), cardiac muscular tissue's gland nucleoside total amount (TAN) all approach normal level, and LPO levels is lower than ischemic reperfusion notes group.This result proves, the medicinal dropping ball for the treatment of coronary heart disease before ischemia during pre-perfusion during with postischemic reperfusion all can be by increasing the cardiac energy deposit, the generation of inhibition lipid peroxide and protecting myocardial cell.

Cardiomyocyte cell death is damage type the most serious in myocardial ischemia-reperfusion, comprises necrocytosis and apoptosis.The apoptotic regulation and control that expressed by several genes.Myocardial infarction rear section myocardial cell apoptosis, probably relevant with Scavenging Oxygen Free Radical with the cell calcium overload due to ischemia.The medicinal dropping ball for the treatment of coronary heart disease can obviously reduce apoptosis of cardiac muscle quantity after myocardial ischemia-reperfusion, dwindles the myocardial infarct size of ischemia-reperfusion rat, significantly alleviates the pathology damage degree, and stronger with the medicinal dropping ball dosage increasing effect for the treatment of coronary heart disease.Carrying out the anoxia experiment in the myocardial cell of cultivating shows, the medicinal dropping ball intervention for the treatment of coronary heart disease can obviously be lowered apoptotic proteins Fas and be expressed, slight upregulation of apoptosis Profilin Bcl-2 expresses, and further the medicinal dropping ball of demonstration treatment coronary heart disease has certain influence to the protein expression of apoptosis-related genes in cell.

The medicinal dropping ball for the treatment of coronary heart disease improves blood capillary circulation albumin outside leakage and mast cell degranulation is one of important symbol of microcirculation disturbance.The medicinal dropping ball induced by endotoxin for the treatment of coronary heart disease and the improvement effect of the caused microcirculation disturbance of ischemia-reperfusion, the Rat Mesenteric Microcirculation obstacle that the medicinal dropping ball of confirmation treatment coronary heart disease causes ischemia-reperfusion improves significantly, and shows: 1. can suppress the early stage albumin outside leakage of ischemia that Radix Salviae Miltiorrhizae can not play a role; 2. effectively suppress mast cell degranulation; 3. suppress the generation of vascular endothelial cell and leukocyte oxide; 4. suppress sticking of leukocyte and vascular endothelial cell; 5. also influential to the interaction of the cell adhesion molecules after ischemia-reperfusion, peroxidating and leukocyte and endotheliocyte.

The medicinal dropping ball for the treatment of coronary heart disease has more obviously impact to patient's bulbar Conjunctiva Microcirculation, thrombelastogram, patient's arteriole vessel diameter broadening after medication, and fine vein blood vessel narrow diameter, arteriole blood flow rate and blood flow have more significantly to be increased.Medicinal dropping ball antioxidation, antiinflammatory, the protection blood vessel endothelium for the treatment of coronary heart disease, the balance between the formation of inhibition atherosclerotic plaque and neointimal hyperplasia vascular endothelial cell associated media nitric oxide (NO) and vasoconstrictive factor endothelin-1 (ET-1) etc. is maintaining the stability of blood vessel.After damage, the medicinal dropping ball for the treatment of coronary heart disease of variable concentrations all obviously alleviates human vascular endothelial damage due to LPS, illustrate that the medicinal dropping ball for the treatment of coronary heart disease has obvious protective effect to vascular endothelial cell.Variable concentrations is treated to the medicinal dropping ball of coronary heart disease for the culture fluid before and after the Hydroperoxide injury modeling, discovery generates at the medicinal dropping ball energy balance NO of prevention and treatment group treatment coronary heart disease, significantly increase cytoactive, endothelial injury due to hydrogen peroxide is had to obvious antagonism.

Atherosclerotic lesion is that a kind of protectiveness inflammation to local damage-fiber proliferative is responded.In the Mottling formation process, lipidosis is most important factor.The medicinal dropping ball treatment for the treatment of coronary heart disease can reduce T-CHOL (TC) and low density lipoprotein, LDL (LDL) cholesterol levels, high density lipoprotein increasing (HDL) cholesterol levels.Ma Xiao waits quietly observing the medicinal dropping ball for the treatment of coronary heart disease to damaging the impact of interior film healing situation with similar method modeling, find that the postoperative NO concentration of medicinal dropping ball group for the treatment of coronary heart disease is apparently higher than matched group, the neointimal hyperplasia degree obviously alleviates than matched group, new intima medium vessels smooth muscle cell and fibrous tissue obviously reduce than matched group, therefore think that the medicinal dropping ball for the treatment of coronary heart disease can promote to damage the reparation of inner membrance, reduces neointimal hyperplasia.

The medicinal dropping ball for the treatment of coronary heart disease increases coronary flow, improves blood flow and uprises lipidemia and can cause vascular endothelial injury, come off, platelet adhesion reaction and gathering.The medicinal dropping ball for the treatment of coronary heart disease can significantly increase the rat coronary flow but not increase heart rate, contributes to improve the supply of heart oxygen and nutrient substance.The medicinal dropping ball for the treatment of coronary heart disease obviously reduces rabbit anteserum TC, triglyceride (TG), LDL, very low density lipoprotein (VLDL) (VLDL) concentration and TC/HDL ratio, and HDL concentration obviously raises.

The medicinal dropping ball for the treatment of coronary heart disease suppresses platelet adhesion reaction and gathering Endothelial dysfunction, endothelium integrity destruction can trigger a series of molecules and biochemical reaction is stagnated blood flow, and blood vessel wall reparation, inhibition or antagonism platelet adhesion reaction and gathering are to prevent thrombotic key link.Medicinal dropping ball D-dimer and the gathering for the treatment of coronary heart disease are to play a role from multiple location, stage construction and many target spots.

The medicinal dropping ball for the treatment of coronary heart disease all has obvious inhibitory action to adenosine diphosphate (ADP) (ADP), thrombin and collagen-induced rat platelet aggregation, and is dose-dependence.The medicinal dropping ball for the treatment of coronary heart disease can suppress high fat and feed dog platelet overactivity.The specificity molecular marker of plasma A membrane granulosa protein-140 (GMP-140) while being platelet activation.Before treatment, treatment group and matched group GMP-140 level are apparently higher than the Healthy People group, after the medicinal dropping ball associating aspirin for treatment for the treatment of coronary heart disease, treatment group angina pectoris symptom, electrocardiogram ischemia improve, blood plasma GMP-140 level is than the remarkable reduction of matched group (singly taking aspirin), with the Healthy People group without significant difference.To the aspirin resistance person, the medicinal dropping ball of add-on coronary heart disease can obviously improve the aspirin resistance state, reduces platelet aggregation rate, and total effective rate is 85%, and the average range of decrease is 51.57%.

Because the medicinal dropping ball for the treatment of coronary heart disease has above-mentioned multiple target effect, it is to all kinds coronary heart disease, comprises that the perioperative treatment etc. of stable or unstable angina pectoris, myocardial infarction, heart failure, silent ischemia and intervention all has remarkable result.

Following experimental data is for illustrating effect of the present invention: the medicine that experimental drug is the embodiment of the present invention 1.

The comparison of medicinal dropping ball aspect the angina pectoris treatment effect of table 1 treatment coronary heart disease

Group	n	Produce effects	Effectively	Invalid	Increase the weight of	Total effective rate/%
							Treatment group	51	20	28	3	0	94.1①
Matched group	51	8	29	13	1	72.5

Annotate: 1. with matched group, compare, analyze U=3.039, P<0.01 through Radit.

The comparison of medicinal dropping ball aspect ECG curative effect of table 2 treatment coronary heart disease

Group	n	Produce effects	Effectively	Invalid	Increase the weight of	Total effective rate/%
							Treatment group	51	11	20	20	0	60.8①
Matched group	51	2	17	30	2	37.3

Annotate: 1. with matched group, compare, analyze U=2.685, P<0.01 through Radit.

Before and after the medicinal dropping ball treatment of table 3 treatment coronary heart disease, hemorheology index changes (x ± s)

The medicinal dropping ball medication left ventricular contractile function of table 4 treatment coronary heart disease is (x ± s) relatively

Annotate: 1. before and after medication, compare P>0.05; 2. compare P<0.05 before and after medication.

That the present invention adopts the modern pharmacy technology to develop is efficient, quick-acting, the pure TCM Dripping Pills of multiple-effect, prevent and treat the coronary heart disease determined curative effect, and can improve the blood capillary circulation, to the diabetes microvascular complication, comprise that diabetic renal papillary necrosis and diabetic nephropathy all have good preventive and therapeutic effect.

The invention has the advantages that: this process route can be realized industrialization, stable and controllable for quality.Related tests shows, the present invention is higher than prior art curative effect, and product purity is high, good absorbing, and steady quality, the purposes novelty, preparation method technique is simple, easy to operate, with low cost simultaneously, is applicable to suitability for industrialized production.

The specific embodiment

Below with embodiment, illustrate the present invention, embodiment is for the ease of understanding the present invention, and the claim do not limited the present invention in any way and core content.

The preparation of the medicinal dropping ball of embodiment 1 treatment coronary heart disease, each component consists of in the weight percent of crude drug effective ingredient: Radix Salviae Miltiorrhizae 82.87%, Radix Notoginseng 16.21%, Borneolum Syntheticum 0.92%;

Step 1, Radix Salviae Miltiorrhizae adds 3 times of amount 95% ethanol, and reflux, extract, 2 hours, filter; Medicinal residues add 2 times of amount 95% ethanol, and reflux, extract, 1 hour, filter, and extracting solution concentrating under reduced pressure, drying, obtain Radix Salviae Miltiorrhizae 95% ethanol extract;

Step 2, Radix Salviae Miltiorrhizae decoction dregs after the ethanol extraction of step 1, add Radix Notoginseng, adds for the first time the aqueous alkali of 8 times of amount PH7-8 to decoct 2 hours, add for the second time 8 times of water gagings to decoct 1 hour, obtain extracting solution, extracting solution is concentrated, adds ethanol to medicinal liquid and measures 60%-70% containing alcohol, standing more than 12 hours, separation of supernatant, reclaim ethanol, receive cream to pol 70%-75%, obtains the Salvia miltiorrhiza and Panax notoginseng extract;

The preparation of the medicinal dropping ball of embodiment 2 treatment coronary heart disease, each component consists of in the weight percent of crude drug effective ingredient: Radix Salviae Miltiorrhizae 19.8%, Radix Notoginseng 78.2%, Borneolum Syntheticum 2%;

Step 1, Radix Salviae Miltiorrhizae adds 2 times of amount 85% ethanol, reflux, extract, 1 time, each 1 hour, to filter, extracting solution concentrating under reduced pressure, drying, obtain Radix Salviae Miltiorrhizae 85% ethanol extract;

Step 2, Radix Salviae Miltiorrhizae decoction dregs after the ethanol extraction of step 1, add Radix Notoginseng, adds for the first time the aqueous alkali of 7 times of amount PH7-8 to decoct 1 hour, add for the second time 6 times of water gagings to decoct 1 hour, obtain extracting solution, extracting solution is concentrated, adds ethanol to medicinal liquid and measures 60%-70% containing alcohol, standing more than 12 hours, separation of supernatant, reclaim ethanol, receive cream to pol 70%-75%, obtains the Salvia miltiorrhiza and Panax notoginseng extract;

Step 3, Radix Salviae Miltiorrhizae 85% ethanol extract of step 1 is suspended in the PEG-4000 of pre-thawing; Add Salvia miltiorrhiza and Panax notoginseng extractum, mix homogeneously; Add Borneolum Syntheticum, mix; The material temperature is 60-100 ℃; The temperature of liquid paraffin is 5-10 ℃, makes drop pill.

The preparation of the medicinal dropping ball of embodiment 3 treatment coronary heart disease, each component consists of in the weight percent of crude drug effective ingredient: Radix Salviae Miltiorrhizae 97%, Radix Notoginseng 2%, Borneolum Syntheticum 1%;

Step 1, Radix Salviae Miltiorrhizae adds 5 times of amount 95% ethanol, reflux, extract, 3 times, each 3 hours, to filter, extracting solution concentrating under reduced pressure, drying, obtain Radix Salviae Miltiorrhizae 95% ethanol extract;

Step 2, Radix Salviae Miltiorrhizae decoction dregs after the ethanol extraction of step 1, add Radix Notoginseng, adds for the first time the aqueous alkali of 6 times of amount PH7-8 to decoct 3 hours, add for the second time 6 times of water gagings to decoct 2 hours, obtain extracting solution, extracting solution is concentrated, adds ethanol to medicinal liquid and measures 60%-70% containing alcohol, standing more than 12 hours, separation of supernatant, reclaim ethanol, receive cream to pol 70%-75%, obtains the Salvia miltiorrhiza and Panax notoginseng extract;

The preparation of the medicinal dropping ball of embodiment 4 treatment coronary heart disease, each component consists of in the weight percent of crude drug effective ingredient: Radix Salviae Miltiorrhizae 95%, Radix Notoginseng 2%, Borneolum Syntheticum 3%;

Step 1, Radix Salviae Miltiorrhizae adds 2 times of amount 75% ethanol, reflux, extract, twice, each 2 hours, to filter, extracting solution concentrating under reduced pressure, drying, obtain Radix Salviae Miltiorrhizae 75% ethanol extract.

Step 2, Radix Salviae Miltiorrhizae decoction dregs after the ethanol extraction of step 1, add Radix Notoginseng, adds for the first time the aqueous alkali of 8 times of amount PH7-8 to decoct 2 hours, add for the second time 6 times of water gagings to decoct 1 hour, obtain extracting solution, extracting solution is concentrated, adds ethanol to medicinal liquid and measures 60%-70% containing alcohol, standing more than 12 hours, separation of supernatant, reclaim ethanol, receive cream to pol 70%-75%, obtains Salvia miltiorrhiza and Panax notoginseng extractum.

Step 3, Radix Salviae Miltiorrhizae 75% ethanol extract of step 1 is suspended in the PEG-4000 of pre-thawing; Add Salvia miltiorrhiza and Panax notoginseng extractum, mix homogeneously; Add Borneolum Syntheticum, mix; The material temperature is 100 ℃; The temperature of liquid paraffin is 10 ℃, makes drop pill.

The preparation of the medicinal dropping ball of embodiment 5 treatment coronary heart disease, each component consists of in the weight percent of crude drug effective ingredient: Radix Salviae Miltiorrhizae 19.8%, Radix Notoginseng 80%, Borneolum Syntheticum 0.2%;

Step 1, Radix Salviae Miltiorrhizae adds 5 times of amount 95% ethanol, and reflux, extract, twice, filter, and extracting solution concentrating under reduced pressure, drying, obtain the tanshinol extract.

Step 2, Radix Salviae Miltiorrhizae decoction dregs after the ethanol extraction of step 1, add Radix Notoginseng, add for the first time the aqueous alkali of 8 times of amount pH values 7 to decoct 2 hours, add for the second time 6 times of water gagings to decoct 1 hour, obtain extracting solution, extracting solution is concentrated, adds ethanol to medicinal liquid and measures 60%-80% containing alcohol, standing more than 12 hours, concentrated, dry, pulverizing, obtain Salvia miltiorrhiza and Panax notoginseng dry powder.

Step 3, the tanshinol extract of step 1 is suspended in the PEG-6000 of pre-thawing; Add Salvia miltiorrhiza and Panax notoginseng dry powder, mix homogeneously; Add Borneolum Syntheticum, mix; The material temperature is 60-100 ℃; The temperature of liquid paraffin is 5-10 ℃, makes drop pill.

The preparation of the medicinal dropping ball of embodiment 6 treatment coronary heart disease, each component consists of in the weight percent of crude drug effective ingredient: Radix Salviae Miltiorrhizae 97%, Radix Notoginseng 2%, Borneolum Syntheticum 1%;

Step 1, Radix Salviae Miltiorrhizae adds 3 times of amount 95% methanol, and reflux, extract, 2 hours, filter; Medicinal residues add 2 times of amount 95% methanol, and reflux, extract, 1 hour, filter, and extracting solution concentrating under reduced pressure, drying, obtain Radix Salviae Miltiorrhizae 95% ethanol extract;

Step 2, Radix Salviae Miltiorrhizae decoction dregs after the methanol extraction of step 1, add Radix Notoginseng, adds for the first time the aqueous alkali of 8 times of amount PH7-8 to decoct 2 hours, add for the second time 8 times of water gagings to decoct 1 hour, obtain extracting solution, extracting solution is concentrated, adds ethanol to medicinal liquid and measures 60%-70% containing alcohol, standing more than 12 hours, separation of supernatant, reclaim ethanol, receive cream to pol 70%-75%, obtains the Salvia miltiorrhiza and Panax notoginseng extract;

The preparation of the medicinal dropping ball of embodiment 7 treatment coronary heart disease, each component consists of in the weight percent of crude drug effective ingredient: Radix Salviae Miltiorrhizae 19.8%, Radix Notoginseng 80%, Borneolum Syntheticum 0.2%;

Step 1, Radix Salviae Miltiorrhizae adds 3 times of amount 95% normal propyl alcohols, and reflux, extract, 2 hours, filter; Medicinal residues add 2 times of amount 95% normal propyl alcohols, and reflux, extract, 1 hour, filter, and extracting solution concentrating under reduced pressure, drying, obtain Radix Salviae Miltiorrhizae 95% ethanol extract;

Step 2, Radix Salviae Miltiorrhizae decoction dregs after the n-propanol extraction of step 1, add Radix Notoginseng, adds for the first time the aqueous alkali of 8 times of amount PH7-8 to decoct 2 hours, add for the second time 8 times of water gagings to decoct 1 hour, obtain extracting solution, extracting solution is concentrated, adds ethanol to medicinal liquid and measures 60%-70% containing alcohol, standing more than 12 hours, separation of supernatant, reclaim ethanol, receive cream to pol 70%-75%, obtains the Salvia miltiorrhiza and Panax notoginseng extract;

Step 3, Radix Salviae Miltiorrhizae 95% ethanol extract of step 1 is suspended in the PEG-4000 of pre-thawing; Add Salvia miltiorrhiza and Panax notoginseng extractum, mix homogeneously; Add Borneolum Syntheticum, mix; The material temperature is 60-100 ℃; The temperature of liquid paraffin, for for 5-10 ℃, is made drop pill.

The preparation of the medicinal dropping ball of embodiment 8 treatment coronary heart disease, each component consists of in the weight percent of crude drug effective ingredient: Radix Salviae Miltiorrhizae 60%, Radix Notoginseng 37%, Borneolum Syntheticum 3%;

Step 1, Radix Salviae Miltiorrhizae adds 12 times of amount 95% n-butyl alcohol, and reflux, extract, 2 hours, filter; Medicinal residues add 2 times of amount 95% n-butyl alcohol, and reflux, extract, 1 hour, filter, and extracting solution concentrating under reduced pressure, drying, obtain Radix Salviae Miltiorrhizae 95% ethanol extract;

Step 2, Radix Salviae Miltiorrhizae decoction dregs after the n-butanol extraction of step 1, add Radix Notoginseng, adds for the first time the aqueous alkali of 8 times of amount PH7-8 to decoct 2 hours, add for the second time 6 times of water gagings to decoct 1 hour, obtain extracting solution, extracting solution is concentrated, adds ethanol to medicinal liquid and measures 60%-65% containing alcohol, standing more than 10 hours, separation of supernatant, reclaim ethanol, receive cream to pol 74%-76%, obtains the Salvia miltiorrhiza and Panax notoginseng extract;

The preparation of the medicinal dropping ball of embodiment 9 treatment coronary heart disease, each component consists of in the weight percent of crude drug effective ingredient: Radix Salviae Miltiorrhizae 80%, Radix Notoginseng 18%, Borneolum Syntheticum 2%;

Step 1, Radix Salviae Miltiorrhizae adds 8 times of amount 80% ethanol, and reflux, extract, 2 hours, filter; Medicinal residues add 4 times of amount 80% ethanol, and reflux, extract, 1 hour, filter, and extracting solution concentrating under reduced pressure, drying, obtain Radix Salviae Miltiorrhizae 80% ethanol extract;

Step 2, Radix Salviae Miltiorrhizae decoction dregs after the ethanol extraction of step 1, add Radix Notoginseng, adds for the first time the aqueous alkali of 8 times of amount PH7-10 to decoct 2 hours, add for the second time 8 times of water gagings to decoct 1 hour, obtain extracting solution, extracting solution is concentrated, adds ethanol to medicinal liquid and measures 50%-60% containing alcohol, standing more than 15 hours, separation of supernatant, reclaim ethanol, receive cream to pol 70%-72%, obtains the Salvia miltiorrhiza and Panax notoginseng extract;

Step 3, Radix Salviae Miltiorrhizae 80% ethanol extract of step 1 is suspended in the PEG-4000 of pre-thawing; Add Salvia miltiorrhiza and Panax notoginseng extractum, mix homogeneously; Add Borneolum Syntheticum, mix; The material temperature is 60-100 ℃; The temperature of liquid paraffin is 5-10 ℃, makes drop pill.

The preparation of the medicinal dropping ball of embodiment 10 treatment coronary heart disease, each component consists of in the weight percent of crude drug effective ingredient: Radix Salviae Miltiorrhizae 65%, Radix Notoginseng 33%, Borneolum Syntheticum 2%;

Step 1, Radix Salviae Miltiorrhizae adds 5 times of amount 75% ethanol, and reflux, extract, 2 hours, filter; Medicinal residues add 3 times of amount 75% ethanol, and reflux, extract, 1 hour, filter, and extracting solution concentrating under reduced pressure, drying, obtain Radix Salviae Miltiorrhizae 75% ethanol extract;

Step 2, Radix Salviae Miltiorrhizae decoction dregs after the ethanol extraction of step 1, add Radix Notoginseng, adds for the first time the aqueous alkali of 8 times of amount PH7-9 to decoct 2 hours, add for the second time 6 times of water gagings to decoct 1 hour, obtain extracting solution, extracting solution is concentrated, adds ethanol to medicinal liquid and measures 60%-70% containing alcohol, standing more than 12 hours, separation of supernatant, reclaim ethanol, receive cream to pol 60%-62%, obtains the Salvia miltiorrhiza and Panax notoginseng extract;

Step 3, Radix Salviae Miltiorrhizae 65% ethanol extract of step 1 is suspended in the PEG-4000 of pre-thawing; Add Salvia miltiorrhiza and Panax notoginseng extractum, mix homogeneously; Add Borneolum Syntheticum, mix; The material temperature is 60-100 ℃; The temperature of liquid paraffin, for for 5-10 ℃, is made drop pill.

The preparation of the medicinal dropping ball of embodiment 11 treatment coronary heart disease, each component consists of in the weight percent of crude drug effective ingredient: Radix Salviae Miltiorrhizae 78%, Radix Notoginseng 21%, Borneolum Syntheticum 1%;

Step 1, Radix Salviae Miltiorrhizae adds 10 times of amount 70% ethanol, and reflux, extract, 2 hours, filter; Medicinal residues add 5 times of amount 70% ethanol, and reflux, extract, 1 hour, filter, and extracting solution concentrating under reduced pressure, drying, obtain Radix Salviae Miltiorrhizae 70% ethanol extract;

Step 2, Radix Salviae Miltiorrhizae decoction dregs after the ethanol extraction of step 1, add Radix Notoginseng, adds for the first time the aqueous alkali of 7 times of amount PH8-10 to decoct 2 hours, add for the second time 7 times of water gagings to decoct 1 hour, obtain extracting solution, extracting solution is concentrated, adds ethanol to medicinal liquid and measures 60%-70% containing alcohol, standing more than 12 hours, separation of supernatant, reclaim ethanol, receive cream to pol 70%-75%, obtains the Salvia miltiorrhiza and Panax notoginseng extract;

Step 3, Radix Salviae Miltiorrhizae 60% ethanol extract of step 1 is suspended in the paraffin of pre-thawing; Add Salvia miltiorrhiza and Panax notoginseng extractum, mix homogeneously; Add Borneolum Syntheticum, mix; The material temperature is 60-100 ℃; The temperature of liquid paraffin is 5-10 ℃, makes drop pill.

The preparation of the medicinal dropping ball of embodiment 12 treatment coronary heart disease, each component consists of in the weight percent of crude drug effective ingredient: Radix Salviae Miltiorrhizae 28%, Radix Notoginseng 70%, Borneolum Syntheticum 2%;

Step 1, Radix Salviae Miltiorrhizae adds 7 times of amount 95% ethanol, and reflux, extract, 2 hours, filter; Medicinal residues add 4 times of amount 95% ethanol, and reflux, extract, 1 hour, filter, and extracting solution concentrating under reduced pressure, drying, obtain Radix Salviae Miltiorrhizae 95% ethanol extract;

Step 2, Radix Salviae Miltiorrhizae decoction dregs after the ethanol extraction of step 1, add Radix Notoginseng, adds for the first time the aqueous alkali of 8 times of amount PH8-9 to decoct 2 hours, add for the second time 8 times of water gagings to decoct 1 hour, obtain extracting solution, extracting solution is concentrated, adds ethanol to medicinal liquid and measures 60%-70% containing alcohol, standing more than 12 hours, separation of supernatant, reclaim ethanol, receive cream to pol 73%-75%, obtains the Salvia miltiorrhiza and Panax notoginseng extract;

Step 3, Radix Salviae Miltiorrhizae 95% ethanol extract of step 1 is suspended in the glyceryl monostearate of pre-thawing; Add Salvia miltiorrhiza and Panax notoginseng extractum, mix homogeneously; Add Borneolum Syntheticum, mix; The material temperature is 60-100 ℃; The temperature of liquid paraffin is 5-10 ℃, makes drop pill.

The preparation of the medicinal dropping ball of embodiment 13 treatment coronary heart disease, each component consists of in the weight percent of crude drug effective ingredient: Radix Salviae Miltiorrhizae 85%, Radix Notoginseng 12%, Borneolum Syntheticum 3%;

Step 1, Radix Salviae Miltiorrhizae adds 6 times of amount 95% ethanol, and reflux, extract, 3 hours, filter; Medicinal residues add 4 times of amount 95% ethanol, and reflux, extract, 1.5 hours, filter, and extracting solution concentrating under reduced pressure, drying, obtain Radix Salviae Miltiorrhizae 95% ethanol extract;

Step 2, Radix Salviae Miltiorrhizae decoction dregs after the ethanol extraction of step 1, add Radix Notoginseng, adds for the first time the aqueous alkali of 6 times of amount PH7-8 to decoct 2 hours, add for the second time 6 times of water gagings to decoct 1 hour, obtain extracting solution, extracting solution is concentrated, adds ethanol to medicinal liquid and measures 60%-70% containing alcohol, standing more than 12 hours, separation of supernatant, reclaim ethanol, receive cream to pol 50%-56%, obtains the Salvia miltiorrhiza and Panax notoginseng extract;

Step 3, Radix Salviae Miltiorrhizae 95% ethanol extract of step 1 is suspended in the poloxamer of pre-thawing; Add Salvia miltiorrhiza and Panax notoginseng extractum, mix homogeneously; Add Borneolum Syntheticum, mix; The material temperature is 60-100 ℃; The temperature of liquid paraffin is 5-10 ℃, makes drop pill.

The preparation of the medicinal dropping ball of embodiment 14 treatment coronary heart disease, each component consists of in the weight percent of crude drug effective ingredient: Radix Salviae Miltiorrhizae 50%, Radix Notoginseng 48%, Borneolum Syntheticum 2%;

Step 1, Radix Salviae Miltiorrhizae adds 9 times of amount 95% ethanol, and reflux, extract, 4 hours, filter; Medicinal residues add 7 times of amount 95% ethanol, and reflux, extract, 2 hours, filter, and extracting solution concentrating under reduced pressure, drying, obtain Radix Salviae Miltiorrhizae 95% ethanol extract;

Step 3, Radix Salviae Miltiorrhizae 95% ethanol extract of step 1 is suspended in the mixture of the paraffin of pre-thawing and PEG-4000; Add Salvia miltiorrhiza and Panax notoginseng extractum, mix homogeneously; Add Borneolum Syntheticum, mix; The material temperature is 60-100 ℃; The temperature of liquid paraffin, for for 5-10 ℃, is made drop pill.

The preparation of the medicinal dropping ball of embodiment 15 treatment coronary heart disease, each component consists of in the weight percent of crude drug effective ingredient: Radix Salviae Miltiorrhizae 90%, Radix Notoginseng 8%, Borneolum Syntheticum 2%;

Step 1, Radix Salviae Miltiorrhizae adds 4 times of amount 95% ethanol, and reflux, extract, 2 hours, filter; Medicinal residues add 3 times of amount 95% ethanol, and reflux, extract, 2 hours, filter, and extracting solution concentrating under reduced pressure, drying, obtain Radix Salviae Miltiorrhizae 95% ethanol extract;

Step 2, Radix Salviae Miltiorrhizae decoction dregs after the ethanol extraction of step 1, add Radix Notoginseng, adds for the first time the aqueous alkali of 8 times of amount PH7-8 to decoct 2 hours, add for the second time 8 times of water gagings to decoct 1 hour, obtain extracting solution, when extracting solution is concentrated into 60 ℃, relative density is 1.02-1.12, adds ethanol to medicinal liquid and measures 60%-70% containing alcohol, standing more than 12 hours, separation of supernatant, reclaim ethanol, receive cream to pol 74%-75%, obtains the Salvia miltiorrhiza and Panax notoginseng extract;

The preparation of the medicinal dropping ball of embodiment 16 treatment coronary heart disease, each component consists of in the weight percent of crude drug effective ingredient: Radix Salviae Miltiorrhizae 82%, Radix Notoginseng 17%, Borneolum Syntheticum 1%;

Step 1, Radix Salviae Miltiorrhizae adds 3 times of amount 90% ethanol, and reflux, extract, 2.5 hours, filter; Medicinal residues add 2 times of amount 90% ethanol, and reflux, extract, 1.5 hours, filter, and extracting solution concentrating under reduced pressure, drying, obtain Radix Salviae Miltiorrhizae 90% ethanol extract;

Step 2, Radix Salviae Miltiorrhizae decoction dregs after the ethanol extraction of step 1, add Radix Notoginseng, adds for the first time the aqueous alkali of 7 times of amount PH7-8 to decoct 3 hours, add for the second time 3 times of water gagings to decoct 0.5 hour, obtain extracting solution, extracting solution is concentrated into 1.05-1.13, adds ethanol to medicinal liquid and measures 50%-60% containing alcohol, standing more than 8 hours, separation of supernatant, reclaim ethanol, receive cream to pol 70%-72%, obtains the Salvia miltiorrhiza and Panax notoginseng extract;

Step 3, Radix Salviae Miltiorrhizae 90% ethanol extract of step 1 is suspended in the PEG-4000 of pre-thawing; Add Salvia miltiorrhiza and Panax notoginseng extractum, mix homogeneously; Add Borneolum Syntheticum, mix; The material temperature is 60-100 ℃; The temperature of liquid paraffin is 5-10 ℃, makes drop pill.

The preparation of the medicinal dropping ball of embodiment 17 treatment coronary heart disease, each component consists of in the weight percent of crude drug effective ingredient: Radix Salviae Miltiorrhizae 60%, Radix Notoginseng 37%, Borneolum Syntheticum 3%;

Step 1, Radix Salviae Miltiorrhizae adds 12 times of amount 75% ethanol, reflux, extract, 1 time, each 1 hour, to filter, extracting solution concentrating under reduced pressure, drying, obtain Radix Salviae Miltiorrhizae 75% ethanol extract;

Step 2, Radix Salviae Miltiorrhizae decoction dregs after the ethanol extraction of step 1, add Radix Notoginseng, adds for the first time the aqueous alkali of 7 times of amount PH7-8 to decoct 2 hours, add for the second time 5 times of water gagings to decoct 1 hour, obtain extracting solution, extracting solution is concentrated, adds ethanol to medicinal liquid and measures 60%-70% containing alcohol, standing more than 12 hours, separation of supernatant, reclaim ethanol, receive cream to pol 70%-75%, obtains the Salvia miltiorrhiza and Panax notoginseng extract;

Step 3, Radix Salviae Miltiorrhizae 75% ethanol extract of step 1 is suspended in the PEG-4000 of pre-thawing; Add Salvia miltiorrhiza and Panax notoginseng extractum, mix homogeneously; Add Borneolum Syntheticum, mix; The material temperature is 60-100 ℃; The temperature of liquid paraffin is 5-10 ℃, makes drop pill.

The preparation of the medicinal dropping ball of embodiment 18 treatment coronary heart disease, each component consists of in the weight percent of crude drug effective ingredient: Radix Salviae Miltiorrhizae 80%, Radix Notoginseng 19%, Borneolum Syntheticum 1%;

Step 1, Radix Salviae Miltiorrhizae adds 10 times of amount 90% ethanol, reflux, extract, 3 times, each 3 hours, to filter, extracting solution concentrating under reduced pressure, drying, obtain Radix Salviae Miltiorrhizae 90% ethanol extract;

Step 2, Radix Salviae Miltiorrhizae decoction dregs after the ethanol extraction of step 1, add Radix Notoginseng, adds for the first time the aqueous alkali of 8 times of amount PH7-8 to decoct 3 hours, add for the second time 7 times of water gagings to decoct 1 hour, obtain extracting solution, extracting solution is concentrated, adds ethanol to medicinal liquid and measures 60%-70% containing alcohol, standing more than 5 hours, separation of supernatant, reclaim ethanol, receive cream to pol 72%-74%, obtains the Salvia miltiorrhiza and Panax notoginseng extract;

The preparation of the medicinal dropping ball of embodiment 19 treatment coronary heart disease, each component consists of in the weight percent of crude drug effective ingredient: Radix Salviae Miltiorrhizae 75%, Radix Notoginseng 23%, Borneolum Syntheticum 2%;

Step 1, Radix Salviae Miltiorrhizae adds 2 times of amount 75% ethanol, reflux, extract, twice, each 2.5 hours, to filter, extracting solution concentrating under reduced pressure, drying, obtain Radix Salviae Miltiorrhizae 75% ethanol extract.

Step 2, Radix Salviae Miltiorrhizae decoction dregs after the ethanol extraction of step 1, add Radix Notoginseng, adds for the first time the aqueous alkali of 7 times of amount PH7-8 to decoct 2 hours, add for the second time 5 times of water gagings to decoct 1 hour, obtain extracting solution, extracting solution is concentrated, adds ethanol to medicinal liquid and measures 60%-70% containing alcohol, standing more than 6 hours, separation of supernatant, reclaim ethanol, receive cream to pol 70%-75%, obtains Salvia miltiorrhiza and Panax notoginseng extractum.

The preparation of the medicinal dropping ball of embodiment 20 treatment coronary heart disease, each component consists of in the weight percent of crude drug effective ingredient: Radix Salviae Miltiorrhizae 45.8%, Radix Notoginseng 54%, Borneolum Syntheticum 0.2%;

Step 1, Radix Salviae Miltiorrhizae adds 4 times of amount 85% ethanol, and reflux, extract, twice, filter, and extracting solution concentrating under reduced pressure, drying, obtain the tanshinol extract.

Step 2, Radix Salviae Miltiorrhizae decoction dregs after the ethanol extraction of step 1, add Radix Notoginseng, add for the first time the aqueous alkali of 8 times of amount PH7-8 to decoct 2 hours, add for the second time 8 times of water gagings to decoct 1 hour, obtain extracting solution, extracting solution is concentrated, adds ethanol to medicinal liquid and measures 60%-70% containing alcohol, standing more than 10 hours, concentrated, dry, pulverizing, obtain Salvia miltiorrhiza and Panax notoginseng dry powder.

The preparation of the medicinal dropping ball of embodiment 21 treatment coronary heart disease, each component consists of in the weight percent of crude drug effective ingredient: Radix Salviae Miltiorrhizae 70%, Radix Notoginseng 28%, Borneolum Syntheticum 2%;

Step 1, Radix Salviae Miltiorrhizae adds 7 times of amount 95% methanol, and reflux, extract, 2 hours, filter; Medicinal residues add 5 times of amount 95% methanol, and reflux, extract, 1 hour, filter, and extracting solution concentrating under reduced pressure, drying, obtain Radix Salviae Miltiorrhizae 95% ethanol extract;

Step 2, Radix Salviae Miltiorrhizae decoction dregs after the methanol extraction of step 1, add Radix Notoginseng, adds for the first time the aqueous alkali of 8 times of amount PH7-9 to decoct 2 hours, add for the second time 8 times of water gagings to decoct 1 hour, obtain extracting solution, extracting solution is concentrated, adds ethanol to medicinal liquid and measures 57%-58% containing alcohol, standing more than 15 hours, separation of supernatant, reclaim ethanol, receive cream to pol 74%-76%, obtains the Salvia miltiorrhiza and Panax notoginseng extract;

The preparation of the medicinal dropping ball of embodiment 22 treatment coronary heart disease, each component consists of in the weight percent of crude drug effective ingredient: Radix Salviae Miltiorrhizae 90%, Radix Notoginseng 17%, Borneolum Syntheticum 3%;

Step 1, Radix Salviae Miltiorrhizae adds 8 times of amount 70% normal propyl alcohols, and reflux, extract, 2 hours, filter; Medicinal residues add 2 times of amount 70% normal propyl alcohols, and reflux, extract, 2 hours, filter, and extracting solution concentrating under reduced pressure, drying, obtain Radix Salviae Miltiorrhizae 70% ethanol extract;

Step 2, Radix Salviae Miltiorrhizae decoction dregs after the n-propanol extraction of step 1, add Radix Notoginseng, adds for the first time the aqueous alkali of 7 times of amount PH7-9 to decoct 2 hours, add for the second time 5 times of water gagings to decoct 1 hour, obtain extracting solution, extracting solution is concentrated, adds ethanol to medicinal liquid and measures 60%-70% containing alcohol, standing more than 10 hours, separation of supernatant, reclaim ethanol, receive cream to pol 54%-56%, obtains the Salvia miltiorrhiza and Panax notoginseng extract;

Step 3, Radix Salviae Miltiorrhizae 70% ethanol extract of step 1 is suspended in the PEG-4000 of pre-thawing; Add Salvia miltiorrhiza and Panax notoginseng extractum, mix homogeneously; Add Borneolum Syntheticum, mix; The material temperature is 60-100 ℃; The temperature of liquid paraffin is 5-10 ℃, makes drop pill.

The preparation of the medicinal dropping ball of embodiment 23 treatment coronary heart disease,

Step 1, Radix Salviae Miltiorrhizae adds 7 times of amount 85% n-butyl alcohol, and reflux, extract, 2 hours, filter; Medicinal residues add 2 times of amount 85% n-butyl alcohol, and reflux, extract, 1 hour, filter, and extracting solution concentrating under reduced pressure, drying, obtain Radix Salviae Miltiorrhizae 85% ethanol extract;

Step 2, Radix Salviae Miltiorrhizae decoction dregs after the n-butanol extraction of step 1, add Radix Notoginseng, adds for the first time the aqueous alkali of 7 times of amount PH7-8 to decoct 2 hours, add for the second time 7 times of water gagings to decoct 1 hour, obtain extracting solution, extracting solution is concentrated, adds ethanol to medicinal liquid and measures 61%-65% containing alcohol, standing more than 12 hours, separation of supernatant, reclaim ethanol, receive cream to pol 70%-75%, obtains the Salvia miltiorrhiza and Panax notoginseng extract;

The preparation of the medicinal tablet of embodiment 24 treatment coronary heart disease, each component consists of in the weight percent of crude drug effective ingredient: Radix Salviae Miltiorrhizae 60%, Radix Notoginseng 38%, Borneolum Syntheticum 2%;

Step 1, Radix Salviae Miltiorrhizae adds 10 times of amount 80% ethanol, and reflux, extract, 2 hours, filter; Medicinal residues add 8 times of amount 80% ethanol, and reflux, extract, 2 hours, filter, and extracting solution concentrating under reduced pressure, drying, obtain Radix Salviae Miltiorrhizae 80% ethanol extract;

Step 2, Radix Salviae Miltiorrhizae decoction dregs after the ethanol extraction of step 1, add Radix Notoginseng, adds for the first time the aqueous alkali of 8 times of amount PH7-8 to decoct 3 hours, add for the second time 6 times of water gagings to decoct 2 hours, obtain extracting solution, extracting solution is concentrated, adds ethanol to medicinal liquid and measures 50%-55% containing alcohol, standing more than 18 hours, separation of supernatant, reclaim ethanol, receive cream to pol 72%-75%, obtains the Salvia miltiorrhiza and Panax notoginseng extract;

Step 3, get Radix Salviae Miltiorrhizae 80% ethanol extract of step 1, adds Salvia miltiorrhiza and Panax notoginseng extractum, and Borneolum Syntheticum, add in right amount and can press starch, mixes; Make tablet.

The preparation of the bolus of drug of embodiment 25 treatment coronary heart disease, each component consists of in the weight percent of crude drug effective ingredient: Radix Salviae Miltiorrhizae 75%, Radix Notoginseng 24%, Borneolum Syntheticum 1%;

Step 1, Radix Salviae Miltiorrhizae adds 9 times of amount 70% ethanol, and reflux, extract, 2 hours, filter; Medicinal residues add 6 times of amount 70% ethanol, and reflux, extract, 1.5 hours, filter, and extracting solution concentrating under reduced pressure, drying, obtain Radix Salviae Miltiorrhizae 70% ethanol extract;

Step 2, Radix Salviae Miltiorrhizae decoction dregs after the ethanol extraction of step 1, add Radix Notoginseng, adds for the first time the aqueous alkali of 7 times of amount PH7-9 to decoct 3 hours, add for the second time 7 times of water gagings to decoct 2 hours, obtain extracting solution, extracting solution is concentrated, adds ethanol to medicinal liquid and measures 60%-70% containing alcohol, standing more than 12 hours, separation of supernatant, reclaim ethanol, receive cream to pol 54%-56%, obtains the Salvia miltiorrhiza and Panax notoginseng extract;

Step 3, get Radix Salviae Miltiorrhizae 70% ethanol extract of step 1, adds Salvia miltiorrhiza and Panax notoginseng extractum, and Borneolum Syntheticum, add appropriate Cera Flava, paraffin, mixes; Make pill.

The preparation of the medicinal dropping ball of embodiment 26 treatment coronary heart disease, each component consists of in the weight percent of crude drug effective ingredient: Radix Salviae Miltiorrhizae 82.87%, Radix Notoginseng 16.21%, Borneolum Syntheticum 0.92%;

Step 3, Radix Salviae Miltiorrhizae 95% ethanol extract of step 1 is suspended in the PEG-4000 of pre-thawing; Add Salvia miltiorrhiza and Panax notoginseng extractum, mix homogeneously; Add Borneolum Syntheticum, mix; The material temperature is 70-100 ℃; The temperature of liquid paraffin, for for 5-10 ℃, is made drop pill.

The preparation of the medicinal dropping ball of embodiment 27 treatment coronary heart disease, each component consists of in the weight percent of crude drug effective ingredient: Radix Salviae Miltiorrhizae 85%, Radix Notoginseng 14%, Borneolum Syntheticum 1%,

Step 1, Radix Salviae Miltiorrhizae adds 4 times of amount 85% ethanol, reflux, extract, 1 time, each 1 hour, to filter, extracting solution concentrating under reduced pressure, drying, obtain Radix Salviae Miltiorrhizae 85% ethanol extract;

Step 2, Radix Salviae Miltiorrhizae decoction dregs after the ethanol extraction of step 1, add Radix Notoginseng, adds for the first time the aqueous alkali of 6 times of amount PH7-8 to decoct 1 hour, add for the second time 6 times of water gagings to decoct 1 hour, obtain extracting solution, extracting solution is concentrated, adds ethanol to medicinal liquid and measures 55%-80% containing alcohol, standing more than 12 hours, separation of supernatant, reclaim ethanol, receive cream to pol 60%-70%, obtains the Salvia miltiorrhiza and Panax notoginseng extract;

The preparation of the medicinal tablet of embodiment 28 treatment coronary heart disease, each component consists of in the weight percent of crude drug effective ingredient: Radix Salviae Miltiorrhizae 82.87%, Radix Notoginseng 16.21%, Borneolum Syntheticum 0.92%;

Step 3, Radix Salviae Miltiorrhizae 95% ethanol extract of step 1; Add Salvia miltiorrhiza and Panax notoginseng extractum, Borneolum Syntheticum, add appropriate amount of starch, mixes, and tabletting, make tablet.

The preparation of the medicament capsule of embodiment 29 treatment coronary heart disease, each component consists of in the weight percent of crude drug effective ingredient: Radix Salviae Miltiorrhizae 19.8%, Radix Notoginseng 78.2%, Borneolum Syntheticum 2%;

Step 3, get Radix Salviae Miltiorrhizae 85% ethanol extract of step 1, adds Salvia miltiorrhiza and Panax notoginseng extractum, and Borneolum Syntheticum, add appropriate dextrin, mucialga of arabic gummy to mix, and granulates; Incapsulate, make capsule.

The preparation of the drug particles of embodiment 30 treatment coronary heart disease, each component consists of in the weight percent of crude drug effective ingredient: Radix Salviae Miltiorrhizae 97%, Radix Notoginseng 2%, Borneolum Syntheticum 1%;

Step 3, get Radix Salviae Miltiorrhizae 95% ethanol extract of step 1, adds Salvia miltiorrhiza and Panax notoginseng extractum, and Borneolum Syntheticum, add microcrystalline Cellulose, sodium carboxymethyl cellulose, gelatine size to mix; Granulate, the granulation agent.

The preparation of the bolus of drug of embodiment 31 treatment coronary heart disease, each component consists of in the weight percent of crude drug effective ingredient: Radix Salviae Miltiorrhizae 95%, Radix Notoginseng 2%, Borneolum Syntheticum 3%;

Step 3, get Radix Salviae Miltiorrhizae 75% ethanol extract of step 1, adds Salvia miltiorrhiza and Panax notoginseng extractum, and Borneolum Syntheticum, add appropriate amount of starch, Mel mix homogeneously; Make pill.

The preparation of the medicinal tablet of embodiment 32 treatment coronary heart disease, each component consists of in the weight percent of crude drug effective ingredient: Radix Salviae Miltiorrhizae 19.8%, Radix Notoginseng 80%, Borneolum Syntheticum 0.2%;

Step 3, get the tanshinol extract of step 1, adds Salvia miltiorrhiza and Panax notoginseng dry powder, and Borneolum Syntheticum, add appropriate mannitol, magnesium oxide, calcium carbonate to mix; Tabletting, make tablet.

The preparation of the medicine oral liquid of embodiment 33 treatment coronary heart disease, each component consists of in the weight percent of crude drug effective ingredient: Radix Salviae Miltiorrhizae 97%, Radix Notoginseng 2%, Borneolum Syntheticum 1%;

Step 3, get Radix Salviae Miltiorrhizae 95% ethanol extract of step 1, adds Salvia miltiorrhiza and Panax notoginseng extractum, and Borneolum Syntheticum is got appropriate cane sugar powder, essence adds appropriate water, makes oral liquid.

The preparation of the medicinal soft capsule of embodiment 34 treatment coronary heart disease, each component consists of in the weight percent of crude drug effective ingredient: Radix Salviae Miltiorrhizae 19.8%, Radix Notoginseng 80%, Borneolum Syntheticum 0.2%;

Step 3, get Radix Salviae Miltiorrhizae 95% ethanol extract of step 1, adds Salvia miltiorrhiza and Panax notoginseng extractum, and Borneolum Syntheticum, get appropriate vegetable oil, according to the soft capsule preparation method, makes soft capsule.

The preparation of the medicament pellet of embodiment 35 treatment coronary heart disease, each component consists of in the weight percent of crude drug effective ingredient: Radix Salviae Miltiorrhizae 60%, Radix Notoginseng 37%, Borneolum Syntheticum 3%;

Step 3, Radix Salviae Miltiorrhizae 95% ethanol extract of step 1, add Salvia miltiorrhiza and Panax notoginseng extractum, and Borneolum Syntheticum, add appropriate calcium stearate, Pulvis Talci, Macrogol 4000, mixes; Make micropill.

The preparation of the pharmaceutical controlled release formulation of embodiment 36 treatment coronary heart disease, each component consists of in the weight percent of crude drug effective ingredient: Radix Salviae Miltiorrhizae 80%, Radix Notoginseng 18%, Borneolum Syntheticum 2%;

Step 3, get Radix Salviae Miltiorrhizae 80% ethanol extract of step 1, adds Salvia miltiorrhiza and Panax notoginseng extractum, and Borneolum Syntheticum, add appropriate polyvinylpyrrolidone (PVP), rubber cement, microcrystalline Cellulose, sodium carboxymethyl cellulose, mixes; Make controlled release preparation.

The preparation of the drug powder of embodiment 38 treatment coronary heart disease, each component consists of in the weight percent of crude drug effective ingredient: Radix Salviae Miltiorrhizae 65%, Radix Notoginseng 33%, Borneolum Syntheticum 2%;

Step 3, get Radix Salviae Miltiorrhizae 65% ethanol extract of step 1, adds Salvia miltiorrhiza and Panax notoginseng extractum, and Borneolum Syntheticum, add appropriate maltose, hydroxypropyl emthylcellulose, mixes, and dry, pulverize, and makes powder.

The preparation of the medicinal tablet of embodiment 39 treatment coronary heart disease, each component consists of in the weight percent of crude drug effective ingredient: Radix Salviae Miltiorrhizae 78%, Radix Notoginseng 21%, Borneolum Syntheticum 1%;

Step 1, Radix Salviae Miltiorrhizae adds 10 times of amount 80% ethanol, and reflux, extract, 2 hours, filter; Medicinal residues add 5 times of amount 80% ethanol, and reflux, extract, 1 hour, filter, and extracting solution concentrating under reduced pressure, drying, obtain Radix Salviae Miltiorrhizae 80% ethanol extract;

Step 3, get Radix Salviae Miltiorrhizae 60% alcohol of step 1, adds Salvia miltiorrhiza and Panax notoginseng extractum, and Borneolum Syntheticum, add appropriate amylum pregelatinisatum, zinc stearate, calcium stearate, mixes, and makes sheet.

The preparation of the medicinal soft capsule agent of embodiment 40 treatment coronary heart disease, each component consists of in the weight percent of crude drug effective ingredient: Radix Salviae Miltiorrhizae 28%, Radix Notoginseng 70%, Borneolum Syntheticum 2%;

Step 3, get Radix Salviae Miltiorrhizae 95% ethanol extract of step 1, adds Salvia miltiorrhiza and Panax notoginseng extractum, and Borneolum Syntheticum, add appropriate vegetable oil, mixes; Make soft capsule according to the soft capsule conventional method.

The preparation of the bolus of drug of embodiment 41 treatment coronary heart disease, each component consists of in the weight percent of crude drug effective ingredient: Radix Salviae Miltiorrhizae 85%, Radix Notoginseng 12%, Borneolum Syntheticum 3%;

Step 3, get Radix Salviae Miltiorrhizae 95% ethanol extract of step 1, adds Salvia miltiorrhiza and Panax notoginseng extractum, adds Borneolum Syntheticum, adds appropriate dextrin, refined honey, mixes, and makes pill.

Claims

1. a preparation method for the treatment of the medicine of coronary heart disease, described medicine is the 19.8%-97% Radix Salviae Miltiorrhizae by percentage by weight, the 2%-80% Radix Notoginseng, the 0.2%-3% Borneolum Syntheticum is processed into, and it is characterized in that, and step is as follows:

Step 3, by the tanshinol extract of step 1, the Salvia miltiorrhiza and Panax notoginseng extract as active constituents of medicine, adds one or more adjuvant together with Borneolum Syntheticum, and the 1-6 that the adjuvant addition is active component doubly, makes for oral medicine.

2. the preparation method of claim 1, is characterized in that, preparation process is:

3. the preparation method of claim 1: it is characterized in that, preparation process is:

4. the preparation method of claim 1: it is characterized in that, preparation process is:

5. the arbitrary described preparation method of claim 1-4: it is characterized in that, step 3 is, tanshinol extract by step 1, the Salvia miltiorrhiza and Panax notoginseng extract mixes with adjuvant with Borneolum Syntheticum, add any or more than one adjuvants, described adjuvant is selected from: fat-soluble substrate and water-soluble base, and wherein fat-soluble substrate is selected from: stearic acid, glyceryl monostearate, insect wax, Cera Flava, paraffin, hydrogenated vegetable oil, semi-synthetic fatty acid ester; Water-soluble base is selected from: Polyethylene Glycol, polyoxyethylene monostearate, poloxamer, sodium stearate, glycerin gelatine; Xylitol and composites of starch, erythritol.

6. the preparation method of claim 5: it is characterized in that, wherein the auxiliary ratio of step 3 Chinese medicine is 1: 1-6.

7. the preparation method of claim 5: it is characterized in that, wherein the auxiliary ratio of step 3 Chinese medicine is 1: 1.9.

8. the preparation method of claim 5: it is characterized in that, wherein said Polyethylene Glycol is PEG-4000.