CN102028723B - Hair-restoring Chinese herbal medicament for treating and preventing alopecia and production method thereof - Google Patents
Hair-restoring Chinese herbal medicament for treating and preventing alopecia and production method thereof Download PDFInfo
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Abstract
The invention discloses a hair-restoring Chinese herbal medicament for treating and preventing alopecia, which is effectively combined with the viscus (Muxielieer) theory and vitality, function and energy (Huwate) theory guidance of 'Kazakh Medicine introduction'. The hair-restoring Chinese herbal medicament is a preparation prepared from one or more than two of various medicinal plants of plumbaginaceae Limonium of Kazakh traditional national medicinal resources serving as raw materials in proportion by water extracting and ethanol extracting. The hair-restoring Chinese herbal medicament comprises all formulations such as liniments, sprays, lotions, pastes and the like applicable to clinical alopecia prevention and treatment. The hair-restoring Chinese herbal medicament particularly has better treatment effects on seborrheic alopecia, psychological pressure alopecia, physical alopecia, chemical alopecia, nutrition metabolic alopecia, infectious alopecia, endocrinopathy alopecia, and alopecia areata, and has the effects of diminishing inflammation, relieving pain, expelling oil, activating blood, enriching blood and restoring hair and the like. The hair-restoring Chinese herbal medicament has the advantages of reasonable formula, exact treatment effect, quick response, and no toxic or side effects such as irritant and the like and is convenient to prepare.
Description
Technical field
The present invention relates to hair growth promoting Chinese herb medicine and the production method thereof of a kind for the treatment of and prevention alopecia.
Background technology
In a investigation to 5779 men in 5 cities such as Beijing, Shanghai, Guangzhou, Hangzhou in 2005, show that the sickness rate of male pattern baldness reaches 25% by Chinese doctors'associations.If alopecia man's the Area Ratio that gets a bit thin on top is done the desert, the gross area that so Chinese man gets a bit thin on top almost has 4725 square kilometres, and it is so large to be equivalent to 1/4 Beijing (3/4 Shanghai, 1.5 Hangzhou, 1.3 Guangzhou); Calculate with China male citizen 800,000,000, China male pattern baldness patient has 200,000,000 people approximately.The global online message of China Daily net: data show, with the quickening pace of modern life, and the enhancing of operating pressure, the change of diet and living habit, the sickness rate of China's Lipid on Young-middle Male alopecia is nearly more than 10 times than increasing before 20 years.The alopecia sickness rate of female adults is also rising year by year simultaneously.But be that kind of disease need to go the cognitive rate of hospital admission still very low to alopecia.
The hair health care not only is related to the self-image problem, more has to be related to how to improve our quality of life problem; Hair the dispelling of main finger skin cleaning (oil, anti-dandruff of dispelling) and scalp abnormal flavour that keep healthy.The generation of scalp abnormal flavour is except outside the Pass having with factors such as hair health (such as folliculitis etc.), diet and living habit, also with body condition and physically and mentally healthy close relation.Routine work pressure is excessive, cause feel exhausted, depression, also can produce the head abnormal flavour.And alopecia comprises the situations such as male alopecia, seborrheic alopecia, mental pressure alopecia, physical property alopecia, alopecia of chemical origin, symptomatic alopecia, Nutrition and Metabolism alopecia, infectious baldness, the alopecia of endocrine disturbance's property, alopecia areata.
There are some researches show that there is microcirculation disturbance in part seborrheic alopecia patient, main manifestations is slow blood flow.Behind Traditional Chinese Medicine of Promoting Blood Circulation To Remove Blood Stasis In The Treatment of Remedying, with hair growth, microcirculation also has improvement in various degree.Take seborrheic alopecia as example, generally be the sex gland hormones dysequilibrium, impel the sebaceous gland hypermetabolism, hypersteatosis causes.Because sebum gathers, and has oppressed the root of hair, affects its growth, causes coming off.Also might be the excessive alopecia that causes of patient's sugar, too much sugar can make sebum increase in vivo, brings out scalp generation seborrheic dermatitis, then a large amount of alopecias.Theory of Chinese medical science thinks that this disease is gastrointestinal dysfunctions mostly, and dampness-heat in the liver and gallbladder is smouldered, the fumigating head surface skin, and the disorderly institute of skin function causes.
The research of using the Chinese medicine and pharmacy theory to carry out alopecia has had long history, but because the restriction of historical conditions, motherland's medical science is not carried out careful clearly differentiation to alopecia always, fails to form the theoretical system of system complete.Along with the systemtheoretical introducing of doctor trained in Western medicine, and according to the principle of differentiation of tcm, research with Chinese medicine, control alopecia just really progressively launches, begin all kinds of alopecias of systematic research, formed China exclusive be combined into the control alopecia scientific research of characteristics with the Chinese and western medicine national medicine.
U.S. of hair dislikes relevant with governor vessel.Governor vessel arises among the born of the same parents, and its branch tells from the spinal column the inside, belongs to kidney.Because governor vessel follows in ridge, enters network in brain, the upper excessively crown belongs to kidney down, has formed a path between kidney, spinal cord, brains, hair.So vigorous when essence in kidney, brain is filled flower, then with governor vessel through the up and flourish foster hair of gas, so hair is just grown densely and glossy.This is the physiological foundation of kidney " its Hua Zaifa ".In the preventing and controlling of carrying out alopecia, the application of Chinese herbal medicine is increasingly extensive; For many years, China has carried out a large amount of work to the research of alopecia medicine, think wherein may exist various for the effective Chinese herbal medicine of alopecia, the phylogenetic system that distributes is extensive, region, ecology are also varied, thereby it is contemplated that they also have various multi-form for the mechanism of action of alopecia, wide prospect that this has just given research herbal control alopecia drug provision.
Kazak traditional national medicine resource plant Plumbaginaceae (Lan Xueke) Statice (Limonium) medicinal plants is perennial herb, this belongs to about 300 kinds, be distributed in all over the world, be produced in Mediterranean, be born in the higher seashore of salinity and area, grassland more, China can be divided into two class areal area, and a class is coastal provinces and regions, and another kind of is the higher Arid Region of soil salt content." Chinese Plants will " puts down in writing 24 kinds such as Limonium suffruticosum Kuntz (Limonium suffruticosum), Limonium gmelinii (Wildl.) Kuntze (Limonium gmelinii), Limonium coralloides Lincz (Limonium coralloides), Limonium myrianthum Kuntz (Limonium myrianthum), Limonium otolepis Kuntz (Limonium otolepis), L. kaschgarieum (Limonium kaschgaricum), Limonium tenellum Kuntz (Limonium tenellum), L. leptolobum (Limonium leptolobum), Limonium wrightii (Hance) Kuntze var. luteum (Hara) Hara (Limonium wrightii var.luteum), Limonium flexuosum (Limonium flexuosum), Limonium franchetii (Limonium franchetii), Herba Limoii Bicoloris (Limonium bicolor), Herba Limonii Gmelinii (Limonium sinense), Limonium potaninii Ik.-Gal. (Limonium aureum var.potaninii), Limonium aureum (Linn.) Hill. var. dielsianum (Wangerin)Peng (Limonium aureum var.dielsianum), Limonium roborowskii Ik.-Gal. (Limonium roborowskii), Limonium chrysocomum (Kar. et Kir.) Kuntze var. semenowii (Herd.)Peng (Limonium chrysocomum var.semenowii), Limonium chrysocomum (Kar. et Kir.) kuntze var. chrysocephalum (Regel)Peng (Limonium chrysocomum var.chrysocephalum), Limonium chrysocomum (Kar. et Kir.) Kuntze var. sedoides (Regel)Peng (Limonium chrysocomum var.sedoides), Limonium drepanostachyum Ik.-Gal subsp. callianthum Peng (Limonium drepanostachyum subsp.callianthum), Limonium wrightii Kuntz (Limonium wrightii), Herba Limonii Gmelinii with yellow flower (Limonium aureum), Limonium chrysocomum kuntze (Limonium chrysocomum), L. drepanostachyum (Limonium drepanostachyum), Xinjiang is produced 11 kinds, Limonium suffruticosum Kuntz, Limonium otolepis Kuntz, Limonium coralloides Lincz, Limonium gmelinii (Wildl.) Kuntze, Limonium myrianthum Kuntz, the checking Herba Limonii Gmelinii, L. kaschgarieum, Limonium roborowskii Ik.-Gal., Herba Limonii Gmelinii with yellow flower, Limonium chrysocomum kuntze, Limonium drepanostachyum Ik.-Gal subsp. callianthum Peng.The 53 pages of another names in flora Volume Four, Xinjiang; Herba Limoii Bicoloris, sweet heart's grass, a prunus mume (sieb.) sieb.et zucc..Sweet heart's grass seeds is spent (Herba Limonii Gmelinii Baidupedia) at flowerpot as family, (" Chinese Herbal Medicine in Xinjiang " is recited as " Da Ye rock pine ").I knew once that the herdsman of Kazak made soap laundry hair washing with the sacsaoul bavin.After my the suddenly alopecia in 1996, the protocol of will enriching blood 100 grams are placed 1 premium on currency and are boiled the cooling hair washing, use and stop alopecia, hair recovery after 5 days normally, begin Herba Limonii Gmelinii is inquired into, use Herba Limonii Gmelinii treatment seborrheic alopecia and alopecia areata disease, participated in national well-known doctor scientific seminar in 1997, on October 3rd, 2010 applied for a patent as applicant the earliest.
The Herba Limonii Gmelinii main chemical compositions comprises tannin, plumbagin, various flavone such as Myricitrin (myricetrin), rutin (runtin), myricetin rhamnoglucoside (myricetin rhamnoglucoside), myricetin (myricetin), isorhamnetin (isorhamnetin), Quercetin (quercetin), myricetin methyl ether (myricetoin monomethyl), kaempferol (tetrahydroxyflavone).Other contains the leucoanthocyanidin condensed tannin, anthocyanidin (cyanidol) is arranged in its composition, Cyanidol Rhamnoside (cyanidol rhamnoside), delphinidin (delphinidol) and pseudo-Cyanidol Rhamnoside (pseudocyanidol rhamnoside).
The Herba Limonii Gmelinii main pharmacological is antiinflammatory, pain relieving, the oil of dispelling, invigorate blood circulation, enrich blood, regulating menstruation, hemostasis, gather the herb using fresh herb when just opening or do and use in spending.
China's traditional Chinese medical science is thought: the seborrheic alopecia seborrheic alopecia claims again male pattern alopecia, and male pattern alopecia belongs to the category of the traditional Chinese medical science " alopecia seborrheica " and " alopecia seborrhoeica ", is commonly called as " getting a bit thin on top " or " topping ".Be apt to occur between twenty and fifty men and women, disease sees that hair becomes gentle, itch with scalp simultaneously, and bull bits or greasy, the whole forehead of severe patient, the end-to-end falling out, alopecia district skin smooth is glossy, so claim the oiliness seborrheic alopecia.A few patients can be without seborrhea, but the hair jaundice, and is dry easily broken and come off, and is called the dryness seborrheic alopecia.The traditional Chinese medical science thinks that the generation of primary disease because of drinking and eating irregularly, accumulates in the damp-heat in the spleen and stomach; Or invade hair outward because of the noxious dryness ailment said due to cold or exposure, or because of deficiency of the liver and kindey, deficiency of YIN insufficiency of blood, hair lose supports.
The effect of research Chinese medicine is relatively paid attention to finding and the research that develops the disease-resistant gene problem, emphasizes the relation of global configuration and gene expression.Comprising: balance organic conception and systems biology; The correspondence between man and universe and environmental genomics; Determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs and pharmacogenomics; Treating the same disease with different methods, treating different diseases with the same therapeutic principle and medicine genetics; Etiology and tumor susceptibility gene; Strengthening vital QI to eliminate pathogenic factors and genomics treatment; The dependency of syndrome and genomics, protrinology.Strengthen simultaneously take gene expression as index, take gene regulation change and functionalized modification as research direction, carry out the research of the multi-component too many levels of Chinese medicine compound, the Accommodation of many target spots, seek the related gene of disease combination, set up " syndrome-gene expression profile ", be conducive to disclose the essence of the 26S Proteasome Structure and Function of TCM Syndrome.
The method kind of alopecia fundamental type and present hair growth mainly contains because the impaired permanent alopecia that causes of hair follicle and because the impaired temporary alopecia that causes of hair follicle short time.
Permanent alopecia is that common male is bald.In some European countries, male's bald rate is up to 40%.The alopecia process of permanent alopecia (being male pattern alopecia) produces gradually.During beginning, the obvious retrude in hair edge of a frons, head exiguous human hair; Then progressively development can develop into only remaining back of head at last, a both sides one circle thin hair, and its main cause has three: inherited genetic factors, the shortage of androgen or imbalance in the blood circulation; Be too obese.In addition, the injured cicatrix that stays of multiple dermatosis or skin, born hair dysplasia, and chemical substance or physical cause all can cause permanent alopecia to the grievous injury that hair follicle causes.
The disease of having a high fever caused by getting often in temporary alopecia.But, according to X-ray, take in metal (such as thallium, stannum and arsenic) or take in drugs, malnutrition, some dermatosis with inflammation, Chronic consumptions, and endocrine disturbance etc. also can cause temporary alopecia.
The therapeutic scheme of male pattern alopecia has two kinds.The first is hair grafting, exactly the hair transplantation of the scalp of going back the long hair place is arrived the not place of long hair, as moving on to the front portion from back of head.Second method is the local drug of topical application.Minot commonly used west ground external application, the continuation alopecia that can effectively stop many reasons to cause promotes the hair restoration at bald or exiguous human hair position.
A. seborrheic alopecia: usually appear at it the young and the middle aged, showing as has thicker oiliness secretion on the scalp, and the hair light is sparse and thin, perhaps hair drying, and dandruff is many, and tarnish is sparse very thin.Solution: it is light to be careful in one's diet, and eats less irritable food, eats fruit, green vegetable or vitamin B6 for oral administration, B2 etc. more.
B. pathologic alopecia: mainly due to virus, antibacterial, high heat hair follicle is had damage, suppressed the hair follicle proper splitting, make hair follicle be in shock state and cause alopecia, such as acute infectious disease, certain medicine of life-time service etc.Solution: have a rest, hair can grow again after physical rehabilitation or the drug withdrawal more.
C. alopecia of chemical origin: harmful chemical causes alopecia to the infringement of scalp tissue, hair follicle cell.Solution: do not use the strong hair dye of zest, agent for permanent hair waving and hair shampoo article inferior.
D. physical property alopecia: air pollutants are stopped up the alopecia that the reasons such as hair follicle, harmful radiation cause.Solution: do not use the nylon comb and the nylon head brush that easily produce static, wear head protector and in time hair washing at the with serious pollution environment of air-borne dust.
E. trophism alopecia: digest and assimilate malfunction and cause malnutrition to cause alopecia.Solution: strengthen nutrition, eat vegetables and fruits, Thallus Laminariae (Thallus Eckloniae), Fructus Mori, Semen Juglandis more.
F. obesity-related alopecia: a large amount of satisfied fatty acid produces refuse after the metabolism in vivo, stops up hair follicle and causes alopecia.Solution: the greasy heavy food that consumes oil less strengthens physical training.
G. hereditary alopecia: alopecia also is to have geneticly, and general male is the dominant inheritance, and the women is the recessive inheritance.
The purpose of hair maintenance is to safeguard the health of hair, can overcome the dandruff or alopecia etc. simultaneously.
But the reason of alopecia and pathology are very complicated, and treatment should be considered more problem.Since alopecia is multifactor causing, prevent and treat so the curative effect index of alopecia and just can not only consider this one side index of maintenance hair, should widen thinking, seek many-sided medicine.
Therefore, a kind of new treatment and hair growth promoting Chinese herb medicine and the production method thereof of prevention alopecia just are suggested.
Summary of the invention
The hair growth promoting Chinese herb medicine and the production method thereof that the purpose of this invention is to provide a kind for the treatment of and prevention alopecia.
The objective of the invention is to be achieved through the following technical solutions:
Chinese medicine of the present invention adopts following waste:
Water extraction: get Chinese crude drug
With Kazak traditional national medicine resource plant Limonium suffruticosum Kuntz (Limonium suffruticosum), Limonium gmelinii (Wildl.) Kuntze (Limonium gmelinii), Limonium coralloides Lincz (Limonium coralloides), Limonium myrianthum Kuntz (Limonium myrianthum), Limonium otolepis Kuntz (Limonium otolepis), L. kaschgarieum (Limonium kaschgaricum), Limonium tenellum Kuntz (Limonium tenellum), L. leptolobum (Limonium leptolobum), Limonium wrightii (Hance) Kuntze var. luteum (Hara) Hara (Limonium wrightii var.luteum), Limonium flexuosum (Limonium flexuosum), Limonium franchetii (Limonium franchetii), Herba Limoii Bicoloris (Limonium bicolor), Herba Limonii Gmelinii (Limonium sinense), Limonium potaninii Ik.-Gal. (Limonium aureum var.potaninii), Limonium aureum (Linn.) Hill. var. dielsianum (Wangerin)Peng (Limonium aureum var.dielsianum), Limonium roborowskii Ik.-Gal. (Limonium roborowskii), Limonium chrysocomum (Kar. et Kir.) Kuntze var. semenowii (Herd.)Peng (Limonium chrysocomum var.semenowii), Limonium chrysocomum (Kar. et Kir.) kuntze var. chrysocephalum (Regel)Peng (Limonium chrysocomum var.chrysocephalum), Limonium chrysocomum (Kar. et Kir.) Kuntze var. sedoides (Regel)Peng (Limonium chrysocomum var.sedoides), Limonium drepanostachyum Ik.-Gal subsp. callianthum Peng (Limonium drepanostachyum subsp.callianthum), Limonium wrightii Kuntz (Limonium wrightii), Herba Limonii Gmelinii with yellow flower (Limonium aureum), Limonium chrysocomum kuntze (Limonium chrysocomum), one or more of L. drepanostachyum (Limonium drepanostachyum), each 1.0～15 weight portion, be preferably each 5～10 weight portion, carry out water extraction 1～3 time: 3～20 water extraordinarily of the fragmentation of said herbal medicine material being pressed afterwards Chinese crude drug weight, heat to 90～105 ℃, slow fire/heating makes and keeps little boiling, each water extraction 5～60 minutes, cross the following sieve of 2mm and get permeate, be preferably 150～500 μ m sieve, with water extraction gained permeate concentrate drying to water content≤50%, get extracting solution, namely obtain Chinese medicine (extracting solution of the present invention, extract).
The 2nd amount of water afterwards of above-mentioned water extraction is that 2～10 times of Chinese crude drug weight are advisable.
Preferably carry out first alcohol extraction before the above-mentioned Chinese crude drug water extraction: be that 60～90% ethanol extracts 1～3 time by 3～10 times of amount concentration of Chinese crude drug weight under 60～90 ℃ of temperature, each 15～45 minutes, get ethanol extract, be concentrated into the extract of dry matter content 〉=50%, and the Chinese medicine that described extract and water extraction is extract obtained or final mixes.
Medicine of the present invention effectively instructs in conjunction with " Kazak's medical science outline " gas, function, energy (recklessly watt) academic theory, and the physician Wu Taiboyidake of Kazak thinks the gas that the body of keeping the body normal function is total and the exclusive gas of internal organs of bringing into play and facilitating the day after tomorrow.So, seborrheic alopecia, the diseases such as all kinds of alopecia areatas belong to the exclusive gas of internal organs that day after tomorrow performance is facilitated, and also are two aspects of opposition of interior and outer, pine and tight, dry and rare wet, absorption and drainage in the yin-yang theory.General character and individual character by positive this prescription medicine of excavation, to improve this prescription to the specific aim of alopecia control, the specializing in clinical treatment in conjunction with the traditional Chinese medical science national doctor organic conception and determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, reach the highest curative effect of composition synergism performance medicine, strengthen the human hair self-repairing capability, alopecia person is recovered gradually, by strengthening the effect of scalp blood circulatory function, improve the vitality state of hair foundation, suppress alopecia, has good curative effect for the alopecia control, diagnosis and treatment at hair loss patient, rejuvenation root of hair as early as possible in the recovery process, for seborrhea, multiple, the alopecia areatas such as single-shot, alopecia totalis can be taken precautions against the alopecia expanded range, recurrence has efficient, low toxicity, without Drug resistance and advantage applied widely, particularly to the man, the alopeciaing therapeutics such as Ms's sudden seborrhea have good therapeutic effect.
Simultaneously, Chinese medicine of the present invention can be made the multiple dosage form series such as spray, liniment, lotion, unguentum, powder, liquid membrane, overcome external Chinese medicament in the past and decocted and used inconvenience and the wasting deficiency of some rare medicinal herbs, Raw material processing in the prescription is accepted or rejected, also can make again multiple dosage form and the occupation modes such as different dosage forms such as medicated bag, medicated cap, medicated bath tub, not only be easy to effect, and can greatly make things convenient for the patient to use.
The specific embodiment
Embodiment 1: get Kazak traditional national drug resource plant Limonium suffruticosum Kuntz, Limonium gmelinii (Wildl.) Kuntze, Limonium coralloides Lincz, Limonium myrianthum Kuntz, Limonium otolepis Kuntz, L. kaschgarieum, Limonium tenellum Kuntz, L. leptolobum, Limonium wrightii (Hance) Kuntze var. luteum (Hara) Hara, Limonium flexuosum, Limonium franchetii, Herba Limoii Bicoloris, Herba Limonii Gmelinii, Limonium potaninii Ik.-Gal., Limonium aureum (Linn.) Hill. var. dielsianum (Wangerin)Peng, Limonium roborowskii Ik.-Gal., Limonium chrysocomum (Kar. et Kir.) Kuntze var. semenowii (Herd.)Peng, Limonium chrysocomum (Kar. et Kir.) kuntze var. chrysocephalum (Regel)Peng, Limonium chrysocomum (Kar. et Kir.) Kuntze var. sedoides (Regel)Peng, Limonium drepanostachyum Ik.-Gal subsp. callianthum Peng, Limonium wrightii Kuntz, Herba Limonii Gmelinii with yellow flower, Limonium chrysocomum kuntze, each 10 weight portion of one or more of L. drepanostachyum, press 10 water extraordinarily of Chinese crude drug weight, heat to 98 ℃ of water extractions 30 minutes, cross 500 μ m sieve and get permeate, to add again 5 times of water gagings in the medicinal residues 98 ℃ of water extractions 20 minutes, cross 500 μ m sieve and get permeate, with above-mentioned water extraction gained permeate under the 0.07Mpa negative pressure, heat to the boiling concentrate drying to water content≤50%, get extract, namely obtain Chinese medicine of the present invention.
Embodiment 2: get Kazak traditional national drug resource plant Limonium suffruticosum Kuntz, Limonium gmelinii (Wildl.) Kuntze, Limonium coralloides Lincz, Limonium myrianthum Kuntz, Limonium otolepis Kuntz, L. kaschgarieum, Limonium tenellum Kuntz, L. leptolobum, Limonium wrightii (Hance) Kuntze var. luteum (Hara) Hara, Limonium flexuosum, Limonium franchetii, Herba Limoii Bicoloris, Herba Limonii Gmelinii, Limonium potaninii Ik.-Gal., Limonium aureum (Linn.) Hill. var. dielsianum (Wangerin)Peng, Limonium roborowskii Ik.-Gal., Limonium chrysocomum (Kar. et Kir.) Kuntze var. semenowii (Herd.)Peng, Limonium chrysocomum (Kar. et Kir.) kuntze var. chrysocephalum (Regel)Peng, Limonium chrysocomum (Kar. et Kir.) Kuntze var. sedoides (Regel)Peng, Limonium drepanostachyum Ik.-Gal subsp. callianthum Peng, Limonium wrightii Kuntz, Herba Limonii Gmelinii with yellow flower, Limonium chrysocomum kuntze, each 30 weight portion of one or more of L. drepanostachyum, be broken into the following bar section of 1cm, granule, measuring concentration by 10 times of above-mentioned Chinese crude drug gross weight is that 70% ethanol extracted 30 minutes under 60 ℃ of temperature, cross 250 μ m sieve, get permeate, measuring concentration by 5 times of above-mentioned Chinese crude drug gross weight again is that 70% ethanol extracted 2 hours under 60 ℃ of temperature, cross 250 μ m sieve, mixing twice gained permeate also, concentrate drying gets alcohol extract as for content of material 〉=85%, Chinese medicine slag after the above-mentioned alcohol extraction is pressed 10 water extraordinarily of Chinese crude drug weight, heat to 98 ℃, twice of water extraction, each 30 minutes, cross 150 μ m and get permeate, water extraction gained permeate concentrate drying to water content≤15%, is got water extract; Namely obtain Chinese medicine of the present invention with extract obtained mixing of above-mentioned water extraction.
Embodiment 3: get Kazak traditional national drug resource plant Limonium suffruticosum Kuntz, Limonium gmelinii (Wildl.) Kuntze, Limonium coralloides Lincz, Limonium myrianthum Kuntz, Limonium otolepis Kuntz, L. kaschgarieum, Limonium tenellum Kuntz, L. leptolobum, Limonium wrightii (Hance) Kuntze var. luteum (Hara) Hara, Limonium flexuosum, Limonium franchetii, Herba Limoii Bicoloris, Herba Limonii Gmelinii, Limonium potaninii Ik.-Gal., Limonium aureum (Linn.) Hill. var. dielsianum (Wangerin)Peng, Limonium roborowskii Ik.-Gal., Limonium chrysocomum (Kar. et Kir.) Kuntze var. semenowii (Herd.)Peng, Limonium chrysocomum (Kar. et Kir.) kuntze var. chrysocephalum (Regel)Peng, Limonium chrysocomum (Kar. et Kir.) Kuntze var. sedoides (Regel)Peng, Limonium drepanostachyum Ik.-Gal subsp. callianthum Peng, Limonium wrightii Kuntz, Herba Limonii Gmelinii with yellow flower, Limonium chrysocomum kuntze, each 15 weight portion of one or more of L. drepanostachyum, be broken into the following bar section of 1cm, granule, be that 90% ethanol respectively extracts 1 time under 85 ℃ of temperature by 8 times of amounts of Chinese crude drug weight and 5 times of amount concentration, each 25 minutes, extracting solution is crossed 250 μ m sieve, gained permeate concentrate drying to dry matter content 〉=90% is got extract, Chinese medicine slag after the above-mentioned alcohol extraction is pressed respectively 8 times and 5 of Chinese crude drug weight, and extraordinarily water is 98 ℃ of lower each water extractions once, kept 20 minutes for the first time, 15 minutes for the second time, cross 150 μ m sieve after each water extraction, with water extraction gained permeate concentrate drying to water content≤10%, get extract, namely obtain Chinese medicine of the present invention with extract obtained mixing of upper alcohol extraction.
Embodiment 4: get by weight Kazak traditional national drug resource plant Limonium suffruticosum Kuntz, Limonium gmelinii (Wildl.) Kuntze, Limonium coralloides Lincz, Limonium myrianthum Kuntz, Limonium otolepis Kuntz, L. kaschgarieum, Limonium tenellum Kuntz, L. leptolobum, Limonium wrightii (Hance) Kuntze var. luteum (Hara) Hara, Limonium flexuosum, Limonium franchetii, Herba Limoii Bicoloris, Herba Limonii Gmelinii, Limonium potaninii Ik.-Gal., Limonium aureum (Linn.) Hill. var. dielsianum (Wangerin)Peng, Limonium roborowskii Ik.-Gal., Limonium chrysocomum (Kar. et Kir.) Kuntze var. semenowii (Herd.)Peng, Limonium chrysocomum (Kar. et Kir.) kuntze var. chrysocephalum (Regel)Peng, Limonium chrysocomum (Kar. et Kir.) Kuntze var. sedoides (Regel)Peng, Limonium drepanostachyum Ik.-Gal subsp. callianthum Peng, Limonium wrightii Kuntz, Herba Limonii Gmelinii with yellow flower, Limonium chrysocomum kuntze, each 10 weight portion of one or more of L. drepanostachyum, be broken into the following bar section of 1cm, granule, be that 80% ethanol extracted 30 minutes under 90 ℃ of temperature by 10 times of Chinese crude drug weight amount concentration, cross 500 μ m sieve, the gained permeate is concentrated into dry matter content 〉=87% gets extract; With the Chinese medicine slag after the above-mentioned alcohol extraction press respectively 10 times, 5 times, 5 of Chinese crude drug weight extraordinarily water 98 ℃ of lower water extractions, 30 minutes for the first time, second and three time each 20 minutes, cross 75 μ m sieve permeate and concentrate drying to water content≤13%, get extract; With above-mentioned water extraction and extract obtained mixing of alcohol extraction namely obtain Chinese medicine of the present invention.
Embodiment 5: get by weight Kazak traditional national drug resource plant Limonium suffruticosum Kuntz, Limonium gmelinii (Wildl.) Kuntze, Limonium coralloides Lincz, Limonium myrianthum Kuntz, Limonium otolepis Kuntz, L. kaschgarieum, Limonium tenellum Kuntz, L. leptolobum, Limonium wrightii (Hance) Kuntze var. luteum (Hara) Hara, Limonium flexuosum, Limonium franchetii, Herba Limoii Bicoloris, Herba Limonii Gmelinii, Limonium potaninii Ik.-Gal., Limonium aureum (Linn.) Hill. var. dielsianum (Wangerin)Peng, Limonium roborowskii Ik.-Gal., Limonium chrysocomum (Kar. et Kir.) Kuntze var. semenowii (Herd.)Peng, Limonium chrysocomum (Kar. et Kir.) kuntze var. chrysocephalum (Regel)Peng, Limonium chrysocomum (Kar. et Kir.) Kuntze var. sedoides (Regel)Peng, Limonium drepanostachyum Ik.-Gal subsp. callianthum Peng, Limonium wrightii Kuntz, Herba Limonii Gmelinii with yellow flower, Limonium chrysocomum kuntze, each 30 weight portion of one or more of L. drepanostachyum plant, be broken into the following bar section of 1cm, granule, press respectively 7 times of amounts of Chinese crude drug weight, 4 times of amounts, 4 times measure concentration is that 68% ethanol respectively extracts 1 time under 90 ℃ of temperature, the time of each time was respectively 30 minutes, 15 minutes, 15 minutes, cross 250 μ m sieve, the gained permeate is concentrated into dry matter content 〉=92% gets extract, with the Chinese medicine slag after the above-mentioned alcohol extraction press Chinese crude drug weight 8 extraordinarily water 98 ℃ of lower water extractions 3 minutes, cross 150 μ m sieve, with gained permeate concentrate drying to water content≤50%, get extract, the extract obtained mixing of above-mentioned water extraction and alcohol extraction namely obtains Chinese medicine of the present invention.
Embodiment 6: get by weight Kazak traditional national drug resource plant Limonium suffruticosum Kuntz, Limonium gmelinii (Wildl.) Kuntze, Limonium coralloides Lincz, Limonium myrianthum Kuntz, Limonium otolepis Kuntz, L. kaschgarieum, Limonium tenellum Kuntz, L. leptolobum, Limonium wrightii (Hance) Kuntze var. luteum (Hara) Hara, Limonium flexuosum, Limonium franchetii, Herba Limoii Bicoloris, Herba Limonii Gmelinii, Limonium potaninii Ik.-Gal., Limonium aureum (Linn.) Hill. var. dielsianum (Wangerin)Peng, Limonium roborowskii Ik.-Gal., Limonium chrysocomum (Kar. et Kir.) Kuntze var. semenowii (Herd.)Peng, Limonium chrysocomum (Kar. et Kir.) kuntze var. chrysocephalum (Regel)Peng, Limonium chrysocomum (Kar. et Kir.) Kuntze var. sedoides (Regel)Peng, Limonium drepanostachyum Ik.-Gal subsp. callianthum Peng, Limonium wrightii Kuntz, Herba Limonii Gmelinii with yellow flower, Limonium chrysocomum kuntze, each 45 weight portion of one or more of L. drepanostachyum, be broken into the following bar section of 1cm, granule, press 10 times of amounts of Chinese crude drug weight, 7 times of amounts and 5 times of amounts add water and respectively extract under 95 ℃ 1 time, the time of each time was respectively 30 minutes, 20 minutes, 15 minutes, cross 180 μ m sieve, the gained permeate is concentrated into water content≤15%, get water extract, namely obtain Chinese medicine of the present invention.
Embodiment 35～44: embodiment 35～44th, and embodiment 28～33 gained Chinese medicines are added an amount of distilled water, Na
3N or other suitable antiseptic are made paste.
Embodiment 45～54: embodiment 45～54th, and embodiment 28～33 gained Chinese medicines are added an amount of refined honey and water, make sweet paste.
Embodiment 55～64: embodiment 55～64th, and embodiment 28～33 gained Chinese medicines are added the propellant mix homogeneously, and the spray bottle of packing into is made spray.
Embodiment 65～74: embodiment 65～74th, and embodiment 28～33 gained Chinese medicines are added excipient such as dextrin etc., make behind the mix homogeneously in the sticking cream tank filling of stream, make the smears.
It below is the diagnosed SARS case that the patient uses medicine of the present invention.
1, Ah certain, man, 50 years old, Kazak.Medical history: first visit on July 20 in 1996.Hair comes off substantially, milphae.Diagnosing it is alopecia totalis.Diagnosis and treatment hair growth promoting after three months, living eyebrow, recovery from illness is so far without recurrence.
2, leaf, man, 40 years old, Kazak.Medical history: first visit on August 17 in 1998.Right side occipitalia speckle shape is bald.Diagnosis: alopecia areata.Use medicine after one month, recovery from illness.So far without recurrence.
3, leaf, man, 21 years old, Kazak.Medical history: first visit on August 20 in 2000.More than patient's readme alopecia half a year.Diagnosis: seborrheic alopecia.Treated two months, improving situation was followed up a case by regular visits to 5 years, without increasing the weight of recurrence.
4, add certain, man, 22 years old, Kazak.December in 2000 first visit on the 18th, readme alopecia more than a year is diagnosed as seborrheic alopecia on inspection.Diagnosis and treatment take a turn for the better after two months, remission, follow up a case by regular visits to the state of an illness have no increase the weight of the recurrence.
5, the hair certain, man, 30 years old, Kazak.Calendar year 2001 first visit on January 9, readme alopecia more than a year is diagnosed as seborrheic alopecia on inspection.Diagnosis and treatment took a turn for the better after three months, follow up a case by regular visits to the state of an illness have no increase the weight of the recurrence.Adhere to using and have no recurrence half a year.
6, breathe out certain, man, 51 years old, Kazak.An Xian occurs in calendar year 2001 first visit on April 3 during readme nineteen fifty-seven 7 years old left and right sides, hair comes off fully afterwards.Be diagnosed as on inspection alopecia totalis.Diagnosis and treatment took effect after three months, followed up a case by regular visits to 2 years state of an illness and had no and increase the weight of recurrence.
7, match certain, man, 40 years old, Kazak.Calendar year 2001 first visit on May 1, medical situation is the large tracts of land alopecia areata, is diagnosed as on inspection multiple alopecia areata.Diagnosis and treatment were fully recovered after three months, followed up a case by regular visits to 3 years state of an illness and had no and increase the weight of recurrence.
8, Hu, man, 20 years old, Kazak.Calendar year 2001 first visit on April 3, readme alopecia three months.Be diagnosed as on inspection alopecia areata.Diagnosis and treatment are fully recovered after two months.Follow up a case by regular visits to after 1 year and do not increase the weight of recurrence.
9, Ma, woman, 29 years old, Han nationality.The first visit on the 29th of calendar year 2001 JIUYUE, readme alopecia 5 years.Be diagnosed as on inspection seborrheic alopecia.Diagnosis and treatment took effect after one month, followed up a case by regular visits to 1 year state of an illness and had no and increase the weight of.
10, Ah certain, man, 25 years old, Kazak.Calendar year 2001 first visit on October 4, readme alopecia more than 5 years.Be diagnosed as on inspection seborrheic alopecia.Diagnosis and treatment took a turn for the better after three months.Follow up a case by regular visits to after 1 year and do not increase the weight of recurrence.
11, difficult to understand certain, man, 33 years old, Kazak.Calendar year 2001 first visit on October 8, the readme alopecia has five to six years.Be diagnosed as on inspection alopecia areata seborrhea.Diagnosis and treatment are fully recovered after two months.Follow up a case by regular visits to after 1 year and do not increase the weight of recurrence.
12, pavilion, woman, 31 years old, Kazak.Calendar year 2001 first visit on October 11, the alopecia of speckle shape is diagnosed as multiple alopecia areata on inspection.Diagnosis and treatment are fully recovered after two months.Follow up a case by regular visits to and do not increase the weight of recurrence in 3 years.
13, heat certain, woman, 47 years old, Kazak.First visit on January 28 in 2002, readme alopecia more than 3 years.Be diagnosed as on inspection seborrheic alopecia.Diagnosis and treatment take effect after two months.Follow up a case by regular visits to after 1 year and do not increase the weight of.
14, leaf, man, 38 years old, Kazak.First visit on March 28 in 2002, readme alopecia 2 years.Be diagnosed as on inspection seborrheic alopecia.Diagnosis and treatment three months do not increase the weight of.Follow up a case by regular visits to after 1 year and do not increase the weight of recurrence.
15, the sea certain, man, 38 years old, Kazak.First visit on April 27 in 2002, the frequent alopecia of readme.Be diagnosed as on inspection multiple alopecia areata.Diagnosis and treatment were fully recovered after three months.Follow up a case by regular visits to after 2 years and do not increase the weight of.
16, Tang, man, 40 years old, Han nationality.First visit on April 30 in 2002, alopecia totalis is diagnosed as alopecia totalis on inspection.Diagnosis and treatment obviously took effect after three months.Follow up a case by regular visits to after 1 year and do not increase the weight of recurrence.
17, ancient certain, woman, 36 years old, the Uygur nationality.First visit on May 20 in 2002, readme alopecia more than five months.Be diagnosed as on inspection the Combination alopecia.Diagnosis and treatment were fully recovered after three months.Follow up a case by regular visits to after 3 years and do not increase the weight of recurrence.
18, Ah certain, woman, 38 years old, Kazak.First visit on June 8 in 2002, the frequent alopecia of readme.Be diagnosed as on inspection multiple alopecia areata.Diagnosis and treatment were fully recovered after three months.Follow up a case by regular visits to after 2 years and do not increase the weight of.
19, leaf, man, 30 years old, Kazak.First visit on July 5 in 2002, readme perspiration, alopecia are diagnosed as seborrheic alopecia on inspection.Diagnosis and treatment took a turn for the better after three months, remission, follow up a case by regular visits to the state of an illness have no increase the weight of the recurrence.
20, leaf, man, 36 years old, Kazak.First visit on July 9 in 2002, readme alopecia more than 2 years is diagnosed as seborrheic alopecia on inspection.Diagnosis and treatment took a turn for the better after two months, follow up a case by regular visits to the state of an illness have no increase the weight of the recurrence.
21, Zhang, man, 50 years old, Han nationality.First visit on August 12 in 2002, readme alopecia more than 2 years.Be diagnosed as on inspection seborrheic alopecia.Diagnosis and treatment took effect after two months, followed up a case by regular visits to 2 years state of an illness and had no and increase the weight of recurrence.
22, wood certain, man, 35 years old, Kazak.JIUYUE in 2002 first visit on the 5th more than medical readme alopecia January, is diagnosed as alopecia areata on inspection.Diagnosis and treatment were fully recovered after two months, followed up a case by regular visits to 1 year state of an illness and had no and increase the weight of recurrence.
23, Ah certain, woman, 9 years old, Kazak.JIUYUE in 2002 first visit on the 10th, readme occipitalia alopecia one month.Be diagnosed as on inspection alopecia areata.Diagnosis and treatment were fully recovered after three months.Follow up a case by regular visits to after 1 year and do not increase the weight of recurrence.
24, the sea certain, man, 43 years old, Kazak.In JIUYUE, 2002 first visit, forehead, occipitalia alopecia.Be diagnosed as on inspection alopecia areata.Diagnosis and treatment were alleviated after three months, followed up a case by regular visits to 2 years state of an illness and had no and increase the weight of.
25, leaf, man, 15 years old, Kazak.First visit in May, 2002, hair, the nearly nothing of milphae.Be diagnosed as on inspection multiple alopecia areata.Diagnosis and treatment took a turn for the better after three months.Follow up a case by regular visits to after 1 year and do not increase the weight of recurrence.
26, storehouse, woman, 39 years old, Kazak.More than the first visit on August 27 in 2002, readme alopecia one year.Be diagnosed as on inspection seborrheic alopecia.Diagnosis and treatment are fully recovered after two months.Do not follow up a case by regular visits to after 1 year and recurred.
27, special certain, man, 39 years old, Kazak.First visit on November 5 in 2002, readme alopecia more than 10 years is examined and is seen the alopecia of speckle shape, is diagnosed as on inspection multiple alopecia areata.Diagnosis and treatment were fully recovered after three months.
28, Ah certain, man, 54 years old, Kazak.December in 2002 first visit on the 1st, right temporo, occipitalia alopecia.Be diagnosed as on inspection multiple alopecia areata.Diagnosis and treatment take a turn for the better after two months.
29, river, woman, 26 years old, Kazak.First visit on April 18 in 2002, readme bilateral temples alopecia 1 year.Be diagnosed as on inspection seborrheic alopecia.Diagnosis and treatment two months take effect.Follow up a case by regular visits to after 1 year and do not increase the weight of recurrence.
30, cloth, man, 34 years old, Kazak.First visit on October 9 in 2002, readme alopecia half a year.Be diagnosed as on inspection alopecia areata.Diagnosis and treatment took a turn for the better after two months.Follow up a case by regular visits to and do not increase the weight of.
31, outstanding certain, woman, 30 years old, Kazak.First visit in November, 2002, readme alopecia more than a year.Be diagnosed as on inspection alopecia areata.Diagnosis and treatment took effect after one month.It is good to follow up a case by regular visits to the state of an illness.
32, wood certain, man, 31 years old, Kazak.First visit on April 28 in 2003, the readme alopecia that repeatedly shows effect.Be diagnosed as on inspection multiple alopecia areata.Diagnosis and treatment took a turn for the better after one month.Follow up a case by regular visits to good.
33, Ma, man, 23 years old, Kazak.First visit on May 9 in 2003, readme alopecia two months.Be diagnosed as on inspection seborrheic alopecia.Diagnosis and treatment took a turn for the better after one month.Follow up a case by regular visits to good.
34, special certain, man, 14 years old, Kazak.First visit on August 5 in 2003, readme alopecia two wheat harvesting periods.Be diagnosed as on inspection alopecia areata.Diagnosis and treatment took a turn for the better after one month.
35, exert certain, man, 31 years old, Kazak.First visit on August 5 in 2003, readme alopecia 1 year.Be diagnosed as on inspection the alopecia of sparse property.Diagnosis and treatment took a turn for the better after three months.
36, suddenly certain, man, 43 years old, Kazak.JIUYUE in 2003 first visit on the 16th, readme forehead alopecia more than 3 years.Be diagnosed as on inspection seborrheic alopecia.Diagnosis and treatment took a turn for the better after two months.
37, leaf, man, 23 years old, Kazak.First visit on August 15 in 2003, readme alopecia more than 2 years.Be diagnosed as on inspection seborrheic alopecia.Diagnosis and treatment took a turn for the better after two months.
38, add certain, man, 31 years old, Kazak.First visit on February 16 in 2004, readme alopecia more than a year.Be diagnosed as on inspection seborrheic alopecia.Diagnosis and treatment took a turn for the better after three months.
39, add certain, woman, 18 years old, Kazak.First visit on February 25 in 2004, readme alopecia more than a year.Be diagnosed as on inspection alopecia areata.Diagnosis and treatment took a turn for the better after two months.Follow up a case by regular visits to good.
40, wood certain, man, 30 years old, Kazak.First visit on May 4 in 2004, readme alopecia more than a year.Be diagnosed as on inspection seborrheic alopecia.Diagnosis and treatment took a turn for the better after three months.Follow up a case by regular visits to good.
41, leaf, man, 42 years old, Kazak.First visit on April 1 in 2004, the rear pillow part alopecia.Be diagnosed as on inspection alopecia areata.Diagnosis and treatment took a turn for the better after one month.Follow up a case by regular visits to good.
42, Ah certain, man, 11 years old, Kazak.First visit on May 26 in 2004, the rear pillow part alopecia.Be diagnosed as on inspection alopecia areata.Diagnosis and treatment took a turn for the better after three months.Follow up a case by regular visits to good.
43, reach certain, man, 28 years old, Kazak.First visit on June 2 in 2004, the readme rear alopecia of repeatedly having hair dyed.Be diagnosed as on inspection seborrheic alopecia.Diagnosis and treatment took a turn for the better after two months.
44, storehouse, woman, 33 years old, Kazak.First visit on June 19 in 2004, readme alopecia half a year.Be diagnosed as on inspection the multiple alopecia areata in the crown.Diagnosis and treatment took a turn for the better after three months.Follow up a case by regular visits to good.
45, Ah certain, man, 23 years old, Kazak.First visit in August, 2004 is more than readme alopecia half a year.Be diagnosed as on inspection seborrheic alopecia.Diagnosis and treatment took a turn for the better after one month.Follow up a case by regular visits to good.
46, Ah certain, woman, 20 years old, Kazak.First visit on August 5 in 2004, the readme alopecia of at every turn washing hair.Be diagnosed as on inspection the alopecia of sparse property.Diagnosis and treatment took a turn for the better after one month.Follow up a case by regular visits to good.
47, beautiful certain, woman, 40 years old, Kazak.First visit on November 18 in 2004, the occipitalia alopecia.Be diagnosed as on inspection alopecia areata.Diagnosis and treatment took a turn for the better after one month.Follow up a case by regular visits to good.
48, hold in the palm certain, man, 18 years old, Kazak.First visit on November 22 in 2004, the tempori dextro alopecia.Be diagnosed as on inspection alopecia areata.Diagnosis and treatment took a turn for the better after one month.Follow up a case by regular visits to good.
49, storehouse, woman, 20 years old, Kazak.December in 2004 first visit on the 29th, readme alopecia more than a year.Be diagnosed as on inspection the alopecia of sparse property.Diagnosis and treatment took a turn for the better after two months.Follow up a case by regular visits to good.
50, Ah certain, man, 42 years old, Kazak.First visit on April 20 in 2005, the alopecia of bilateral temporo occipitalia.Be diagnosed as on inspection multiple alopecia areata.Diagnosis and treatment took a turn for the better after two months.Follow up a case by regular visits to good.
Claims (5)
1. the production method of hair growth promoting Chinese herb medicine of a treatment and prevention alopecia is characterized in that containing at least following technical process:
Water extraction: get Limonium suffruticosum Kuntz, Limonium gmelinii (Wildl.) Kuntze, Limonium coralloides Lincz, Limonium myrianthum Kuntz, Limonium otolepis Kuntz, L. kaschgarieum, Limonium tenellum Kuntz, L. leptolobum, Limonium wrightii (Hance) Kuntze var. luteum (Hara) Hara, Limonium flexuosum, Limonium franchetii, Herba Limoii Bicoloris, Herba Limonii Gmelinii, Limonium potaninii Ik.-Gal., Limonium aureum (Linn.) Hill. var. dielsianum (Wangerin)Peng, Limonium roborowskii Ik.-Gal., Limonium chrysocomum (Kar. et Kir.) Kuntze var. semenowii (Herd.)Peng, Limonium chrysocomum (Kar. et Kir.) kuntze var. chrysocephalum (Regel)Peng, Limonium chrysocomum (Kar. et Kir.) Kuntze var. sedoides (Regel)Peng, Limonium drepanostachyum Ik.-Gal subsp. callianthum Peng, Limonium wrightii Kuntz, Herba Limonii Gmelinii with yellow flower, Limonium chrysocomum kuntze, any one or more 0.5～15 weight portions of L. drepanostachyum, carry out water extraction 1～3 time: 1～30 water extraordinarily of above-mentioned Chinese crude drug fragmentation being pressed afterwards Chinese crude drug weight, heat to boiling, 90～105 ℃, afterwards slow fire heating, each water extraction 5～30 minutes, cross the following sieve of 2mm or silk, filter cloth is got permeate, gets the filtrate of aqueous extract.
2. the production method of hair growth promoting Chinese herb medicine of a treatment and prevention alopecia is characterized in that:
Alcohol extraction: get Limonium suffruticosum Kuntz, Limonium gmelinii (Wildl.) Kuntze, Limonium coralloides Lincz, Limonium myrianthum Kuntz, Limonium otolepis Kuntz, L. kaschgarieum, Limonium tenellum Kuntz, L. leptolobum, Limonium wrightii (Hance) Kuntze var. luteum (Hara) Hara, Limonium flexuosum, Limonium franchetii, Herba Limoii Bicoloris, Herba Limonii Gmelinii, Limonium potaninii Ik.-Gal., Limonium aureum (Linn.) Hill. var. dielsianum (Wangerin)Peng, Limonium roborowskii Ik.-Gal., Limonium chrysocomum (Kar. et Kir.) Kuntze var. semenowii (Herd.)Peng, Limonium chrysocomum (Kar. et Kir.) kuntze var. chrysocephalum (Regel)Peng, Limonium chrysocomum (Kar. et Kir.) Kuntze var. sedoides (Regel)Peng, Limonium drepanostachyum Ik.-Gal subsp. callianthum Peng, Limonium wrightii Kuntz, Herba Limonii Gmelinii with yellow flower, Limonium chrysocomum kuntze, any one or more 0.5～15 weight portions of L. drepanostachyum, carry out 80% to 95% soak with ethanol or heating extraction 1～3 time: 1～30 ethanol extraordinarily of above-mentioned Chinese crude drug fragmentation being pressed afterwards Chinese crude drug weight, the each immersion 1～7 day, cross the following sieve of 2mm or silk, filter cloth is got permeate, gets the filtrate of ethanol extract.
3. the production method of hair growth promoting Chinese herb medicine of described treatment and prevention alopecia according to claim 1 and 2, it is characterized in that: carry out first alcohol extraction before the Chinese crude drug water extraction during described water extraction: getting concentration by 3～10 times of Chinese crude drug weight is that 60～90% ethanol is 60～90 ℃ of lower extractions 1～3 time, each 15～45 minutes, get extracting solution, be concentrated into dry matter content 〉=80% and get extract.
4. according to claim 1 and 2 or the production method of hair growth promoting Chinese herb medicine of 3 described treatments and prevention alopecia, it is characterized in that: described water extraction liquid and ethanol extract carry out assembly, get mixed extract.
5. the hair growth promoting Chinese herb medicine of a treatment and prevention alopecia, it is characterized in that according to claim 1～4 each described methods produce.
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