CN102028672B - Microporous spongy film preparation and preparation method thereof - Google Patents
Microporous spongy film preparation and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a microporous spongy film preparation and a preparation method thereof. The microporous spongy film preparation comprises active ingredients in a treatment effective amount, which are supported on a microporous spongy film for the film preparation. A basic net structure is made of polymer materials, medicines can be dissolved or mixed in the materials, and a large number of micropores are formed in the film preparation through a pore forming agent; the microporous spongy film preparation has an in-vivo pharmacokinetics mode similar to that of corresponding orally disintegrating tablets and solution tablets in the market, can be used for quickly taking effect, has the biological effects equivalent to corresponding preparations in the market, can be quickly disintegrated in the oral cavity, is high in bioavailability and favorable for clinical emergency treatment, and is thicker and better in handfeel than the common film preparation; the preparation process is simplified, and the production time is shortened; and the prepared film preparation is uniform, attractive and elegant.
Description
Technical field
The present invention relates to a kind of medicine film preparation.
Background technology
The medicine film preparation is as far back as promptly existing many researchs of nineteen seventies, like tranquilizer film (Chinese Journal of Pharmaceuticals, 1976,12 (19)); Diphenoxylate medicine film (Chinese Journal of Pharmaceuticals, 1976,12 (22)), external applied contraceptive film (Chinese Journal of Pharmaceuticals; 1977,4-5 (45)), nitroglycerin medicine film (Chinese Journal of Pharmaceuticals, 1977; 12 (5)), rhodexin film (Chinese Journal of Pharmaceuticals, 1980,4 (18)); Clonidine sustained release film formulation (Chinese Journal of Pharmaceuticals, 1981,3 (141)) etc.Chinese Pharmacopoeia also records (Pharmacopoeia of People's Republic of China 1995 editions, 2000 editions, 2005 editions, 2010 editions) to membrane as official preparation.This dosage form does not have fast development for various reasons so far at home, and also not seeing has new medicine film to get permission to produce at home, maybe with lack modern production machine, it is relevant to lack packing attractive in appearance easy to use.For this reason, the inventor has applied for the patent of new packaged form of packaging machine, the membrane of production machine, the membrane of membrane, to promote membrane development at home.
By contrast, external membrane develops rapidly and vigorously, as the membrane of nonprescription drugs, the FDA approved of the U.S. 9 products and going on the market, use membrane like breath freshening, antianaphylactic diphenhydramine membrane etc.
Membrane is also easily manufactured because of it as prescription drugs, and adjuvant is few, and is easy to carry, does not need the water clothes; Rapid-action, more the numerous advantages of economic dispatch are replacing oral formulations such as oral cavity disintegration tablet, lyophilizing sheet, dispersible tablet, and present many patents, as paste adhesion membrane (the US pat on oral mucosa; 6750,921), can be bonded in the oral cavity the more slowly membrane of corrosion (US pat, 5800; 832), double-deck membrane (USpat, 5700 are arranged also; 478), non-oral cavity adhesion property, membrane (WO 2008040534 (A2)) that can disintegrate in the oral cavity have then been simulated the mechanism of action of oral cavity disintegration tablet, in vivo dynamically identical with it of medicine.Various prescriptions are used for pain relieving with membrane; Sleep disorder; Be particularly suitable for engulfing patient, child, the easy patient that vomiting takes place of difficulty; U.S. FDA was ratified the famotidine film in 2005, ratified the production of Ondansetron Hydrochloride film again in 2010, and sign prescription medication film will come into the market with fast speeds.
For a kind of medicine film preparation, whether can in the oral cavity, collapse diffusingly fast, be a kind of important index of test medicine film preparation.In order to improve the dissolution velocity of membrane, reduce its thickness usually as far as possible; Yet the membrane that makes is too thin, and feel is not good.Therefore, need present medicine film preparation be improved, should improve its dissolution rate, feel is preferably arranged again, to satisfy the needs of clinical practice.
Summary of the invention
One of the object of the invention provides a kind of spongy thin film that is used for the medicine film preparation with micropore, to overcome the defective that prior art exists, satisfies clinical needs.
Two of the object of the invention provides the described spongiform method for preparing that is used for the thin film of medicine film preparation with micropore.
Three of the object of the invention provides a kind of microporous sponge shape medicine film preparation.
The spongy thin film that is used for the medicine film preparation with micropore of the present invention, its component comprise water-soluble high-molecular material and are dispersed in the water-insoluble micropowder in the described water-soluble high-molecular material;
Said water-soluble high-molecular material is preferably HPMC, PVA, HPC, CMC-Na or PEO;
Said water-insoluble micropowder is preferably microcrystalline Cellulose micropowder, starch, fine silica powder, CMC micropowder or chitosan micropowder, and the particle diameter of micropowder is 0.1～5 μ m;
The weight ratio of water-soluble high-molecular material and water-insoluble micropowder is:
Water-soluble high-molecular material: water-insoluble micropowder=1: 0.1～1.5;
Preferably:
Water-soluble high-molecular material: water-insoluble micropowder=1: 0.2～1.25;
The aperture of said micropore is 10～100nm, and the thickness of thin film is 0.01～0.2mm;
Further, in the described thin film, also comprise other adjuvants, described other adjuvants are more than one in antioxidant, tween 80, correctives, plasticizer or the pigment, and in the gross weight of thin film, the weight content of other adjuvants is 0.01～30%;
The method for preparing of said thin film comprises the steps:
(1) pore creating material is added the water slip of described water-soluble high-molecular material, the weight concentration of the water slip of water-soluble high-molecular material is 10～30%;
The component of said pore creating material comprises described water-insoluble micropowder and absorption solvent above that, and the parts by weight of water-insoluble micropowder and the weight portion of solvent are:
100 parts of water-insoluble micropowders
100～900 parts of solvents
Said solvent is selected from more than one in ethanol or the acetone, preferred alcohol;
The adding weight of pore creating material, count with the weight of butt water-soluble high-molecular material and water-insoluble micropowder:
Water-soluble high-molecular material: water-insoluble micropowder=1: 0.1～1.5;
Preferably:
Water-soluble high-molecular material: water-insoluble micropowder=1: 0.2～1.25;
Term " butt " refers to and does not contain water;
(2) be coated with fabric film then, obtain the thin film presoma;
Described to be coated with fabric film be the conventional method in this area, and like the method for research (Chinese Journal of Pharmaceuticals, 1977,12 (5)) bibliographical information of nitroderm TTS, the present invention repeats no more;
(3) the thin film presoma that step (2) is obtained is being higher than under the temperature of solvent evaporates dryly, obtains the described thin film that is used for the medicine film preparation;
Solvent volatilizees from the water-insoluble micropowder and disengages, and stays next micropore at every water-insoluble micropowder place, and because water-insoluble micropowder capillarity; Solvent disengages and is slowly; Help keeping uniform bubble to generate,, thereby just can form bubble comparatively uniformly owing to the water-insoluble micropowder is distributed in the macromolecule serosity; What of the particle diameter of water-insoluble micropowder and quantity of solvent have determined the aperture of micropore again, what of the amount of micropore.
Microporous sponge shape medicine film preparation of the present invention, comprise load on the above-mentioned thin film that is used for the medicine film preparation, the treatment effective amount of actives;
Preferably, in the gross weight of described microporous sponge shape medicine film preparation, the content of said active component is 0.1～40%, and most preferred is 1～20%;
Described active component; So long as in water, ethanol and acetone kind solvent solubilized or dispersible; All can load in the described thin film, include, but are not limited to the medicine of voglibose, Lizakuputan benzoate, Zolpidemtar Trate, ondansetron, codeine phosphate, vaccine or polypeptide;
Preferably, described microporous sponge shape medicine film preparation is:
Voglibose microporous sponge shape membrane, comprise load on voglibose on the described thin film that is used for the medicine film preparation, the treatment effective dose,
Lizakuputan benzoate microporous sponge shape membrane, comprise load on Lizakuputan benzoate on the described thin film that is used for the medicine film preparation, the treatment effective dose,
Ondansetron micropore membrane, comprise load on ondansetron on the described thin film that is used for the medicine film preparation, the treatment effective dose or
The compound codeine phosphate membrane, comprise load on the described thin film that is used for the medicine film preparation, the codeine phosphate of treatment effective dose and the mixture of promethazine, the weight ratio of codeine phosphate and promethazine is: 1: 0.625;
The method for preparing of described microporous sponge shape medicine film preparation comprises the steps:
(1) pore creating material and active component are added the water slip of described water-soluble high-molecular material, the weight concentration of the water slip of water-soluble high-molecular material is 10～30%;
The component of said pore creating material comprises described water-insoluble micropowder and absorption solvent above that, and the parts by weight of water-insoluble micropowder and the weight portion of solvent are:
100 parts of water-insoluble micropowders
100～900 parts of solvents
Said solvent is selected from more than one in ethanol or the acetone, preferred alcohol;
The adding weight of pore creating material, in the weight of butt water-soluble high-molecular material and water-insoluble micropowder, water-soluble high-molecular material: water-insoluble micropowder=1: 0.1～1.5;
Preferably:
Water-soluble high-molecular material: water-insoluble micropowder=1: 0.2～1.25;
(2) be coated with fabric film then, obtain the medicine carrying thin film;
Described to be coated with fabric film be the conventional method in this area, and like the method for research (Chinese Journal of Pharmaceuticals, 1977,12 (5)) bibliographical information of nitroderm TTS, the present invention repeats no more;
(3) the medicine carrying thin film that step (2) is obtained is being higher than under the temperature of solvent evaporates dryly, obtains described microporous sponge shape medicine film preparation, and solvent volatilizees from the water-insoluble micropowder and disengages; And stay next micropore at every water-insoluble micropowder place; And because water-insoluble micropowder capillarity, solvent disengages and is slowly to help keeping uniform bubble to generate; Because the water-insoluble micropowder is distributed in the macromolecule serosity; Thereby just can form bubble comparatively uniformly, the aperture that how much has determined micropore again of the particle diameter of water-insoluble micropowder and amount of alcohol, the amount of micropore how much.
The present invention adopts macromolecular material commonly used to constitute basic RF, and medicine can be dissolved in or be mixed in these materials, in membrane, forms a large amount of micropores through pore creating material;
The inventor finds, after in the water slip that simply solvent is added above-mentioned macromolecular material, in system film dry run; Solvent receives thermal evaporation, can in film, stay bubble, but this bubble very easy by as yet not evaporable macromolecular material replace; Therefore, pore-creating character is relatively poor, or Kong Taixiao;
For this reason, the present invention joins in the aqueous solution of above-mentioned macromolecular material after the insoluble micropowder of water used in solvent is adsorbed, and can overcome above-mentioned defective; Obtain described microporous sponge shape medicine film preparation; Simultaneously, solvent has the froth breaking effect concurrently, makes solution not have the uneven bubble of size and exists.And in the preparation process, do not need deaeration to handle, make preparation technology more simple, convenient.
The method for using of microporous sponge shape medicine film preparation of the present invention, identical with the membrane of routine, can stick in the oral cavity.
Corresponding oral cavity disintegration tablet, tablet dissolved sheet can have pharmacokinetics pattern in the similar body on microporous sponge shape medicine film preparation of the present invention and the market, and can be used for snap action, and with market on the corresponding preparation bioequivalence.Can either in the oral cavity, collapse diffusingly fast, bioavailability is high, helps clinical first aid and uses; Membrane thickness than common is big again, good hand touch; And simplified preparation technology, shortened the production time; The membrane that makes is even, attractive in appearance, generous.
Description of drawings
Fig. 1 is the electromicroscopic photograph of the thin film that is used for the medicine film preparation of embodiment 1.
Fig. 2 is the electromicroscopic photograph of the thin film that is used for the medicine film preparation of embodiment 2.
Fig. 3 is the external stripping curve of the medicine film preparation of embodiment 3.
Fig. 4 is the external stripping curve of the medicine film preparation of embodiment 4.
Fig. 5 is the blood drug level-time graph behind the rat oral administration of medicine film preparation of embodiment 4.
The specific embodiment
Embodiment 1
The method for preparing that is used for the thin film of medicine film preparation:
(1) the 100g pore creating material is added 100g HPMC water slip, HPMC water slip weight concentration is 25%;
The component of pore creating material comprises that particle diameter is the microcrystalline Cellulose and absorption ethanol above that of 1 μ m, and the parts by weight of microcrystalline Cellulose and the weight portion of solvent are:
100 parts of microcrystalline Cellulose
300 parts of ethanol
(2) adopt the method for research (Chinese Journal of Pharmaceuticals, 1977,12 (5)) bibliographical information of nitroderm TTS then, be coated with fabric film, obtain the thin film presoma;
(3) the thin film presoma that step (2) is obtained obtains the described thin film that is used for the medicine film preparation in 80 ℃ of dryings, and thickness is 0.06mm, and the aperture of micropore is 50nm.Its electromicroscopic photograph is seen Fig. 1.
As can beappreciated from fig. 1 be full of micropore in the film; One deck sponge of the structure of whole film just as downcutting; This membrane is different from fully no matter the hard-packed of other is adherent or not stick to the membrane on the oral mucosa, and is similar to the freeze-dried instant tablet, a large amount of abrim pores.The existence of a large amount of micropores makes moisture be easy to get in the film, and therefore, it is diffusing to accelerate collapsing of membrane.The feel of the film of microporous sponge shape, mouthfeel are all good than general membrane.
Embodiment 2
The method for preparing that is used for the thin film of medicine film preparation:
(1) with the water slip of 50g pore creating material, 1g antioxidant adding 100g PVA, PVA water slip weight concentration is 20%;
The component of said pore creating material comprises that particle diameter is the chitosan and absorption acetone above that of 0.5 μ m, and the parts by weight of chitosan and the weight portion of solvent are:
100 parts of chitosans
400 parts in acetone
(2) adopt the method for research (Chinese Journal of Pharmaceuticals, 1977,12 (5)) bibliographical information of nitroderm TTS then, be coated with fabric film, obtain the thin film presoma;
(3) the thin film presoma that step (2) is obtained obtains the described thin film that is used for the medicine film preparation in 60 ℃ of dryings, and thickness is 0.1mm, and the aperture of micropore is 80nm.Its electromicroscopic photograph is seen Fig. 2.
Embodiment 3
Voglibose microporous sponge shape membrane:
With the water slip of 100g pore creating material, 2g voglibose, 2g tween 80 adding 100g HPMC, HPMC water slip weight concentration is 25%.
Other are with embodiment 1.
Get 6 of membrane, clamp with paperclip respectively, adopt dissolution method (two appendix XC of Chinese Pharmacopoeia version in 2010 three therapeutic methods of traditional Chinese medicine) device; 100ml is a dissolution medium with phosphate buffer (pH5.8), and rotating speed is that per minute 30 changes, from test sample contact dissolution medium; Timing immediately in the time of 10,20,30 seconds, 1,2 minute, is got solution 1ml respectively; Filter; Get subsequent filtrate, every stripping quantity is measured and calculated to fluorescence derivatization method behind the employing post according to HPLC (two appendix VD of Chinese Pharmacopoeia version in 2010).Its external stripping curve is seen Fig. 3.
Visible from Fig. 3; The external stripping of voglibose film of the present invention is very fast; Similar with the external stripping of the voglibose film (product of Japanese Kyukyu yakuhin Kogyo K.K.) of Japan, and film of the present invention looses soon than collapsing of Japanese membrane, and this is owing to porous reason.
Embodiment 4
Lizakuputan benzoate microporous sponge shape film
With the water slip of 40g pore creating material and 60g Lizakuputan benzoate adding 100g HPC, HPC water slip weight concentration is 20%.
The component of said pore creating material comprises that particle diameter is the starch and absorption ethanol above that of 1 μ m, and the parts by weight of starch and alcoholic acid weight portion are:
100 parts of starch
100 parts of ethanol
Other are with embodiment 1.
Adopt the method for HPLC mensuration (Chinese Journal of Pharmaceuticals, 2004,35 (10)) bibliographical information of Lizakuputan benzoate content and related substance, detect, external stripping curve is seen Fig. 4.
Visible from Fig. 4, the external stripping of Rizatriptan benzoate film agent is fast and fully, explain that spongy film is easy to absorb moisture because of the hole more, be prone to open collapse diffusing.
Adopt Liquid chromatographic method for the determination of rizatriptan inhuman plasma (Journal of Chromatography B; 805 (2004)) method of bibliographical information; Blood drug level behind the rat oral administration (3mg/kg) of mensuration Rizatriptan benzoate film agent, the result sees Fig. 5.Tmax is 30min, and Cmax is 0.22 μ g/ml.
Embodiment 5
The ondansetron microporous membrane
Ondansetron is the antiemetic in the oncotherapy, commercially available existing oral cavity disintegration tablet, dispersible tablet, general sheet etc.The vomiting patient should not be with a large amount of water tablet of swallowing, and is therefore more suitable with membrane.
Method for preparing:
With the water slip of 40g pore creating material, 40g ondansetron, 10g glycerol, 10g sweeting agent aspartame adding 100gPVA, PVA water slip weight concentration is 12.5%;
The component of said pore creating material comprises that particle diameter is the microcrystalline Cellulose and absorption acetone above that of 0.5 μ m, and the parts by weight of microcrystalline Cellulose and the weight portion of acetone are:
100 parts of microcrystalline Cellulose
500 parts in acetone
Other are with embodiment 1.
Get 6 of membrane; Each clip becomes the thin film of 1cm * 1cm size; Use the stainless steel silk folder of two-layer sieve aperture internal diameter respectively as 2.0mm; According to the inspection of the method (two appendix X of Chinese Pharmacopoeia version in 2010 A) under the disintegration inspection technique tablet item, observe and record membrane off-bottom and the time through screen cloth.The dissolving time limit of ondansetron microporous membrane of the present invention is very fast, is 30 ± 3s.
Embodiment 6
The compound codeine phosphate film
Method for preparing:
The promethazine of 20g pore creating material, 40g codeine phosphate, 25g, the correctives acesulfame potassium of 15g are added the water slip of 100g CMC-Na, and water slip weight concentration is 10%;
The component of said pore creating material comprises that particle diameter is the silicon dioxide and absorption ethanol above that of 1 μ m, and the parts by weight of silicon dioxide and alcoholic acid weight portion are:
100 parts of fine silica powders
900 parts of ethanol
Other are with embodiment 1.
6 of these article of getting are observed and record membrane off-bottom and the time through screen cloth according to embodiment 5.Be limited to 40 ± 5s during the dissolving of compound codeine phosphate film of the present invention.
Claims (22)
1. the spongy thin film that is used for the medicine film preparation that has micropore; It is characterized in that; Its component comprises water-soluble high-molecular material and is dispersed in the water-insoluble micropowder in the described water-soluble high-molecular material; Said water-soluble high-molecular material is HPMC, PVA, HPC, CMC-Na or PEO; Said water-insoluble micropowder is microcrystalline Cellulose micropowder, starch, fine silica powder, CMC micropowder or chitosan micropowder, and the particle diameter of micropowder is 0.1～5 μ m, and the weight ratio of water-soluble high-molecular material and water-insoluble micropowder is: water-soluble high-molecular material: water-insoluble micropowder=1: 0.1～1.5.
2. the spongy thin film that is used for the medicine film preparation with micropore according to claim 1 is characterized in that water-soluble high-molecular material: water-insoluble micropowder=1: 0.2～1.25.
3. the spongy thin film that is used for the medicine film preparation with micropore according to claim 1 is characterized in that the aperture of said micropore is 10～100nm, and the thickness of thin film is 0.01～0.2mm.
4. according to each described spongy thin film that is used for the medicine film preparation of claim 1～3, it is characterized in that, in the described thin film, also comprise other adjuvants with micropore.
5. according to each described spongy method for preparing that is used for the thin film of medicine film preparation of claim 1～3, it is characterized in that, comprise the steps: with micropore
(1) pore creating material is added the water slip of described water-soluble high-molecular material,
The component of said pore creating material comprises described water-insoluble micropowder and absorption solvent above that;
(2) be coated with fabric film then, obtain the thin film presoma;
(3) the thin film presoma that step (2) is obtained is being higher than under the temperature of solvent evaporates dryly, obtains the described thin film that is used for the medicine film preparation.
6. method according to claim 5 is characterized in that, the weight concentration of the water slip of water-soluble high-molecular material is 10～30%.
7. method according to claim 5 is characterized in that, the parts by weight of water-insoluble micropowder and the weight portion of solvent are: 100 parts of water-insoluble micropowders, 100～900 parts of solvents.
8. method according to claim 5 is characterized in that, the adding weight of pore creating material is counted with the weight of butt water-soluble high-molecular material and water-insoluble micropowder: water-soluble high-molecular material: water-insoluble micropowder=1: 0.1～1.5.
9. method according to claim 8 is characterized in that water-soluble high-molecular material: water-insoluble micropowder=1: 0.2～1.25.
10. microporous sponge shape medicine film preparation, comprise load on each described thin film that is used for the medicine film preparation of claim 1～3, the treatment effective amount of actives.
11. microporous sponge shape medicine film preparation according to claim 10 is characterized in that, described active component is solubilized or dispersible medicine in water, ethanol and acetone kind solvent.
12. microporous sponge shape medicine film preparation according to claim 10; It is characterized in that described active component includes, but are not limited to the medicine of voglibose, Lizakuputan benzoate, Zolpidemtar Trate, ondansetron, compound codeine phosphate, vaccine or polypeptide.
13. voglibose microporous sponge shape membrane comprises loading on voglibose on each described thin film that is used for the medicine film preparation of claim 1～4, the treatment effective dose.
14. Lizakuputan benzoate microporous sponge shape membrane comprises loading on Lizakuputan benzoate on each described thin film that is used for the medicine film preparation of claim 1～4, the treatment effective dose.
15. ondansetron micropore membrane comprises loading on ondansetron on each described thin film that is used for the medicine film preparation of claim 1～4, the treatment effective dose.
16. the compound codeine phosphate membrane, comprise load on each described thin film that is used for the medicine film preparation of claim 1～4, the codeine phosphate of treatment effective dose and the mixture of promethazine.
17. the method for preparing of each described microporous sponge shape medicine film preparation of claim 10～12 comprises the steps:
(1) pore creating material and active component are added the water slip of water-soluble high-molecular material;
The component of said pore creating material comprises described water-insoluble micropowder and absorption solvent above that
(2) be coated with fabric film then, obtain the medicine carrying thin film;
(3) the medicine carrying thin film that step (2) is obtained is being higher than drying under the temperature of solvent evaporates, obtains microporous sponge shape medicine film preparation.
18. method according to claim 17 is characterized in that, the weight concentration of the water slip of water-soluble high-molecular material is 10～30%.
19. method according to claim 17 is characterized in that, the parts by weight of water-insoluble micropowder and the weight portion of solvent are: 100 parts of water-insoluble micropowders, 100～900 parts of solvents.
20. method according to claim 17 is characterized in that, said solvent is selected from more than one in ethanol or the acetone.
21. method according to claim 17 is characterized in that, the adding weight of pore creating material, and in the weight of butt water-soluble high-molecular material and water-insoluble micropowder, water-soluble high-molecular material: water-insoluble micropowder=1: 0.1～1.5.
22. method according to claim 21 is characterized in that, water-soluble high-molecular material: water-insoluble micropowder=1: 0.2～1.25.
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| CN102641258B (en) * | 2012-04-24 | 2013-04-24 | 上海现代药物制剂工程研究中心有限公司 | Spongy dextromethorphan hydrobromide film agent with micro-pore and preparation method thereof |
| CN102670570B (en) * | 2012-05-04 | 2013-06-05 | 上海现代药物制剂工程研究中心有限公司 | Microporous spongy ondansetron hydrochloride film agent and preparation method thereof |
| CN102657635B (en) * | 2012-05-04 | 2013-08-07 | 上海现代药物制剂工程研究中心有限公司 | Spongy asenapine sublingual film agent with micropores and preparation method thereof |
| US20140073678A1 (en) * | 2012-09-12 | 2014-03-13 | Monosol Rx, Llc | Anti-pain and anti-nausea and/or vomiting combinatorial compositions |
| CN103142608B (en) * | 2013-02-28 | 2015-02-11 | 上海现代药物制剂工程研究中心有限公司 | Codeine phosphate and promethazine hydrochloride compound membranous preparation |
| CN104000801B (en) * | 2014-06-06 | 2016-09-21 | 山东大学 | A kind of oral cavity rapid release membrane comprising Ondansetron Hydrochloride solid dispersion |
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| CN101574330A (en) * | 2009-06-12 | 2009-11-11 | 上海现代药物制剂工程研究中心有限公司 | Rizatriptan benzoate film agent |
| CN101574329A (en) * | 2009-06-12 | 2009-11-11 | 上海现代药物制剂工程研究中心有限公司 | Zolpidem tartrate film agent |
| CN101732286A (en) * | 2010-01-22 | 2010-06-16 | 上海现代药物制剂工程研究中心有限公司 | Voglibose film and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101574330A (en) * | 2009-06-12 | 2009-11-11 | 上海现代药物制剂工程研究中心有限公司 | Rizatriptan benzoate film agent |
| CN101574329A (en) * | 2009-06-12 | 2009-11-11 | 上海现代药物制剂工程研究中心有限公司 | Zolpidem tartrate film agent |
| CN101732286A (en) * | 2010-01-22 | 2010-06-16 | 上海现代药物制剂工程研究中心有限公司 | Voglibose film and preparation method thereof |
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