CN102028230B - Health care product auxiliary material and application thereof - Google Patents
Health care product auxiliary material and application thereof Download PDFInfo
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- CN102028230B CN102028230B CN201010577752.6A CN201010577752A CN102028230B CN 102028230 B CN102028230 B CN 102028230B CN 201010577752 A CN201010577752 A CN 201010577752A CN 102028230 B CN102028230 B CN 102028230B
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Abstract
The invention discloses a health care product auxiliary material and the application thereof. The ingredient of the auxiliary material is L-arginine alpha a-ketoglutarate salt, wherein the molar ratio of the L-arginine to the alpha a-ketoglutarate is 1:2 to 5:1, and the L-arginine and the alpha a-ketoglutarate are mixed to obtain salt. The health care product auxiliary material can be added to health care products for regulating metabolism, improving immunity, promoting blood circulation, preventing and curing disease of heart head blood-vessel, resisting oxidation, removing free radicals, resisting aging, improving menopausal symptoms, promoting growth, maintaining reproductive function, protecting liver function, reducing weight, etc. The weight ratio of the amount of the L-arginine alpha a-ketoglutarate salt added in the health care products to the main ingredient of the health care products is 10:1 to 1:200.
Description
Technical field
The present invention relates to technical field of health care products, be specifically related to a kind of composition and application thereof that can be used as health care product auxiliary material.
Background technology
L-arginine-alpha-ketoglutarate, English name is L-Arginine-alpha-Ketoglutarate, and English is called for short AAKG, is different from the crystalline mixture of L-arginine and KG, and there is not sat linkage between the two in common mixt.L-arginine-alpha-ketoglutarate is white or light yellow crystal, and soluble in water, HCl and NaOH solution, be slightly soluble in ethanol, is insoluble to acetone, ether etc.
L-arginine-alpha-ketoglutarate is a kind of amidates health products that on current international market, sales volume increases day by day, as functional nutrient hardening agent and liver-protecting medicine, be mainly used in physique and strengthen tonic, promote rapid growth and the recovery of muscle, promote the absorption of liver cell to nutrition and energy, safeguard that liver function normally waits effect.Its major physiological mechanism is that L-arginine-alpha-ketoglutarate can promote nitric oxide production level in a short time, promotes and expansion muscular movement, and then promotes rapid growth and the recovery of muscle, gains in strength and energy.
Zoopery shows, supplementary AAKG can increase the level of arginine and glutamine in skeletal muscle, plays the effect of stimulating immune system function simultaneously.A research for the supplementary AAKG (15g/d) of children also shows, level, promotion that AAKG can promote synthetic auxin comprise the amino acid metabolisms such as IGF (IGF1), glutamine and glutamate, supplement after 5 months and improve significantly in rate of rise.Equally, AAKG can promote the secretion of auxin and the insulin of postoperative patient, and its mesostate glutamine and proline also can promote that wound heals again.In the research for AKG Anticatabolism, there is Metabolism and hypermetabolic 14 multiple trauma patients have participated in experiment, give AAKG 20g tested group of every day, demonstrate aspect the blood level of the free amino acids such as protein conversion, insulin, auxin and glutamine, proline, arginine, obtain equally the highest significantly.Research for healthy male shows in addition, gives the AAKG dosage of 10g every day, and its insulin level raises 20～30%, and supplement separately in the research group of arginine or KG, does not observe this rising.Cell in vitro is cultivated and is shown, AAKG can significantly induce HF's growth, and this cell is similar to muscle fibre cell, and its effect has significant dose-effect relationship, and corresponding single arginine or KG do not have this specific character.
L-arginine-alpha-ketoglutarate, in the aqueous solution, can dissociate and form arginine and KG, thereby also can be used as KG or arginic donor, under certain conditions, as the substitute of arginine or KG, applies.Arginine is the important source material of the conditionally essential amino acid that can not lack in human body and synthetic protein, creatine, is the important mesostate of organism urea cycle, is also nitric oxide production lead.And KG has very strong regulating and controlling effect to the metabolism of protein, and be important substance and the production capacity carrier that promotes tricarboxylic acid cycle.(US Patent No. P 7645742; USP 6905707; USP 7645742)
In existing document, have no L-arginine-alpha-ketoglutarate and be applied in health products as auxiliary material.
Summary of the invention
The object of this invention is to provide a kind of auxiliary material that health products are produced that can be applicable to, be applicable to adding to regulate metabolism, improve immunity, promote circulation, control cardiovascular and cerebrovascular disease, anti-oxidant, remove free radical, anti-ageing, improve menopause symptom, enhancing development, safeguard reproductive function, in the health products such as liver function protecting, fat-reducing.
The object of the present invention is achieved like this: this auxiliary material is L-arginine-alpha-ketoglutarate, wherein L-arginine and KG can the mol ratio proportioning salify of 1: 2～5: 1 (preparation method is shown in Chinese patent 200710063477.4,200710063478.9,200710063479.3, CN101591271A).L-arginine-alpha-ketoglutarate the amount joining in health products is 10: 1～1: 200 with health products predominant quantity ratio.
The present invention has following effect:
1, using L-arginine-alpha-ketoglutarate as auxiliary material, join the health products that improve immunity, as in spirulina, colostrum, vitamins health products, can improve its constitutional effect;
2, using L-arginine-alpha-ketoglutarate as auxiliary material, join the health products that promote circulation, control cardiovascular and cerebrovascular disease, in ginkgo biloba extract, garlic P.E, albumen powder, can improve the effect of its softening blood vessel, anti-bolt;
3, using L-arginine-alpha-ketoglutarate as auxiliary material, join antidotal health products, in grape seed extract, can improve its anti-oxidant, to remove free radical effect;
4, L-arginine-alpha-ketoglutarate is joined to the health products that improve menopause symptom, as evening primrose oil or containing in the nourishing the liver and kidney antitoxic heart-soothing and sedative class Chinese medical extract health products such as glutinous rehmannia, the root of herbaceous peony, the fruit of Chinese wolfberry, the seed of Chinese dodder, Radix Angelicae Sinensis, the tuber of dwarf lilyturf, the coptis, the red sage root, keel, oyster, Fructus meliae toosendan, the fruit of Chinese magnoliavine, the membrane of a chicken's gizzard, can improve and warm sweating, dizziness and tinnitus, irritated, soreness and weakness of waist and knees, the climacteric metancholia symptoms such as insomnia and dreamful sleep;
5, L-arginine-alpha-ketoglutarate is joined containing carrotene or containing in the yang-tonifying classes such as the fleece-flower root, auricularia auriculajudae, Poria cocos, the fruit of Chinese wolfberry, mulberry fruit, dried longan pulp, coix seed, lotus seeds, date, Morinda officinalis, the fruit of Chinese wolfberry, Semen Juglandis, dogwood fruit, the fruit of Cherokee rose and tonifying Qi class Chinese medical extract health products, can improve the effect that it improved the health, safeguarded reproductive function;
6, L-arginine-alpha-ketoglutarate added to pollen pini or globe artichoke or containing protecting the liver in class Chinese medical extract health products the fruit of Chinese magnoliavine, ginseng, American ginseng, the tuber of dwarf lilyturf etc., can improve the effect of its protecting liver, lowering enzymes;
7, L-arginine-alpha-ketoglutarate is added to slimming health product, in l-cn, can improve the effect of its fat loss of weight that disappears.
The specific embodiment
Below will by instantiation, the invention will be further described:
Example one
Auxiliary material using L-arginine-alpha-ketoglutarate as vitamin B complex tablet: wherein L-arginine and KG salify ratio are mol ratio 2: 1, the weight ratio of addition and vitamin B compound is 10: 1 (the concrete content of vitamin B compound: vitamin B1 3g, vitamin B2 1.5g, pyridoxamine 0.2g, niacinamide 10g, calcium pantothenate 1g, be total to 15.7g), add 157gL-arginine-alpha-ketoglutarate, with filler starch 200g, disintegrant microcrystalline cellulose 120g, wetting agent PVPK30 (5%, w/v 80% ethanolic solution) granulate in right amount, dry, add dolomol 2.5g, be pressed into 1000, obtain.
Example two
Auxiliary material using L-arginine-alpha-ketoglutarate as albumen powder electuary, wherein L-arginine and KG salify ratio are mol ratio 5: 1, the weight ratio of addition and soyabean protein powder is 1: 10, be soyabean protein powder 5000g, L-arginine-alpha-ketoglutarate 500g, granulates, dry, be distributed into 100 bags, obtain.
Example three
Auxiliary material using L-arginine-alpha-ketoglutarate as grape seed extract soft capsule, wherein L-arginine and KG salify ratio are mol ratio 1: 1, the weight ratio of addition and grape seed extract (solid extract and essential oil) is 1: 1, grape pip solid extract 25g wherein, grape-kernel oil 200g, L-arginine-alpha-ketoglutarate 225g, suspending agent beeswax 15g, anticorrisive agent ditert-butylhydro quinone 0.05g, heating stirs, capsule casing material is gelatin, pour the capsule 's content preparing in pellet processing machine pill sizing, dry, polishing, pack and get final product.
Example four
Auxiliary material using L-arginine-alpha-ketoglutarate as evening primrose oil capsule, wherein L-arginine and KG salify ratio are mol ratio 4: 1, the weight ratio of addition and evening primrose oil is 1: 50, be evening primrose oil 100g, L-arginine-alpha-ketoglutarate 2g, filler Icing Sugar 50g, disintegrant dried starch 30g, wetting agent PVP K30 (5%, w/v 80% ethanolic solution) appropriate, granulate, after being dried, add dolomol 1g, be pressed into 500, obtain.
Example five
Auxiliary material using L-arginine-alpha-ketoglutarate as carrotene microcapsules, wherein L-arginine and KG salify ratio are mol ratio 1: 2, addition and carrotene weight ratio are 1: 100, be carrotene 100g, L-arginine-alpha-ketoglutarate 1g, is stirred into suspension with 2000g vegetable oil, dissolve in 1000ml acetone, at the uniform velocity be added drop-wise in beta-schardinger dextrin-saturated solution, constant temperature stirs, refrigeration, suction filtration,, with distilled water and acetone washing postlyophilization, obtain.
Example six
Auxiliary material using L-arginine-alpha-ketoglutarate as Schisandra chinens P.E sheet, wherein L-arginine and KG salify ratio are mol ratio 3: 1, the weight ratio of addition and Schisandra chinens P.E is 1: 200, be Schisandra chinens P.E 800g, L-arginine-alpha-ketoglutarate 4g, microcrystalline cellulose 320g, CMS is received 400g, calcium bicarbonate 16g, with distilled water is wetting, granulate, dry, adding 3.5g superfine silica gel powder is lubricant, compacting in flakes, obtains.
Example seven
Auxiliary material using L-arginine-alpha-ketoglutarate as l-cn sheet, wherein L-arginine and KG salify ratio are mol ratio 2: 1, the weight ratio of addition and l-cn is 1: 1, i.e. l-cn 100g, L-arginine-alpha-ketoglutarate 100g, starch 200g, Cellulose Acetate Phthalate 0.3g, granulates with 10% starch slurry, after being dried, adds dolomol 2g, be pressed into 1000, obtain.
Claims (2)
1. an application process for health care product auxiliary material, is characterized in that: L-arginine and KG salify, take molar ratio computing as 1:2 ~ 5:1, and as auxiliary material, join in health products; Addition is: L-arginine-alpha-ketoglutarate amount is 10:1 ~ 1:200 with health products predominant quantity ratio.
2. the method for claim 1, it is characterized in that, using L-arginine-alpha-ketoglutarate as health care product auxiliary material, join any in vitamin B complex tablet, albumen powder electuary, grape seed extract soft capsule, evening primrose oil capsule, carrotene microcapsules, Schisandra chinens P.E sheet, l-cn sheet; L-arginine and KG salify, take molar ratio computing as 1:2 ~ 5; Addition is: L-arginine-alpha-ketoglutarate amount is 10:1 ~ 1:200 with health products predominant quantity ratio.
3. the method for claim 1, it is characterized in that, when the auxiliary material using L-arginine-alpha-ketoglutarate as vitamin B complex tablet adds, L-arginine and KG salify ratio are mol ratio 2:1, the weight ratio of addition and vitamin B compound is 10:1, wherein the concrete content of vitamin B compound: Cobastab
13g, Cobastab
21.5g, Cobastab
60.2g, niacinamide 10g, calcium pantothenate 1g, altogether 15.7g; Add 157gL-arginine-alpha-ketoglutarate, with filler starch 200g, disintegrant microcrystalline cellulose 120g, the ethanolic solution of wetting agent PVP K30 mass volume ratio 5%, concentration of alcohol is 80%, granulates, dry, add dolomol 2.5g, be pressed into 1000, obtain.
4. the method for claim 1, it is characterized in that, auxiliary material using L-arginine-alpha-ketoglutarate as albumen powder electuary, wherein L-arginine and KG salify ratio are mol ratio 5:1, the weight ratio of addition and soyabean protein powder is 1:10, be soyabean protein powder 5000g, L-arginine-alpha-ketoglutarate 500g, granulates, dry, be distributed into 100 bags, obtain.
5. the method for claim 1, it is characterized in that, auxiliary material using L-arginine-alpha-ketoglutarate as grape seed extract soft capsule, wherein L-arginine and KG salify ratio are mol ratio 1:1, the weight ratio of addition and grape seed extract is 1:1, grape pip solid extract 25g wherein, grape-kernel oil 200g, L-arginine-alpha-ketoglutarate 225g, suspending agent beeswax 15g, anticorrisive agent ditert-butylhydro quinone 0.05g, heating stirs, capsule casing material is gelatin, pour the capsule 's content preparing in pellet processing machine pill sizing, dry, polishing, pack and get final product.
6. the method for claim 1, it is characterized in that, auxiliary material using L-arginine-alpha-ketoglutarate as evening primrose oil capsule, wherein L-arginine and KG salify ratio are mol ratio 4:1, the weight ratio of addition and evening primrose oil is 1:50, be evening primrose oil 100g, L-arginine-alpha-ketoglutarate 2g, filler Icing Sugar 50g, disintegrant dried starch 30g, the ethanolic solution of wetting agent PVP K30 mass volume ratio 5%, concentration of alcohol is 80%, granulates, and after being dried, adds dolomol 1g, be pressed into 500, obtain.
7. the method for claim 1, it is characterized in that, auxiliary material using L-arginine-alpha-ketoglutarate as carrotene microcapsules, wherein L-arginine and KG salify ratio are mol ratio 1:2, addition and carrotene weight ratio are 1:100, be carrotene 100g, L-arginine-alpha-ketoglutarate 1g, is stirred into suspension with 2000g vegetable oil, dissolves in 1000ml acetone, at the uniform velocity be added drop-wise in beta-schardinger dextrin-saturated solution, constant temperature stirs, refrigeration, suction filtration, with distilled water and acetone washing postlyophilization, obtain.
8. the method for claim 1, it is characterized in that, auxiliary material using L-arginine-alpha-ketoglutarate as Schisandra chinens P.E sheet, wherein L-arginine and KG salify ratio are mol ratio 3:1, the weight ratio of addition and Schisandra chinens P.E is 1:200, be Schisandra chinens P.E 800g, L-arginine-alpha-ketoglutarate 4g, microcrystalline cellulose 320g, CMS is received 400g, calcium bicarbonate 16g, with distilled water is wetting, granulate, dry, adding 3.5g superfine silica gel powder is lubricant, compacting in flakes, obtains.
9. the method for claim 1, is characterized in that, the auxiliary material using L-arginine-alpha-ketoglutarate as l-cn sheet, wherein L-arginine and KG salify ratio are mol ratio 2:1, the weight ratio of addition and l-cn is 1:1, i.e. l-cn 100g, L-arginine-alpha-ketoglutarate 100g, starch 200g, Cellulose Acetate Phthalate 0.3g, granulates with 10% starch slurry, after being dried, adds dolomol 2g, be pressed into 1000, obtain.
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| ITUB20153396A1 (en) * | 2015-09-03 | 2017-03-03 | Icim Int S R L | Antioxidant association and compositions containing it. |
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| CN104256651B (en) * | 2014-10-22 | 2016-03-30 | 何瑞红 | Improve composition and method of making the same and the application of male's sexual |
| CN105661234A (en) * | 2016-01-22 | 2016-06-15 | 江苏艾兰得营养品有限公司 | Beverage with function of quick physical energy recovery and method for preparing beverage with function of quick physical energy recovery |
| RU2635373C1 (en) * | 2016-08-25 | 2017-11-13 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Национальный исследовательский Мордовский государственный университет им. Н.П. Огарёва" | Biologically active additive for increasing general working ability |
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Cited By (1)
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| ITUB20153396A1 (en) * | 2015-09-03 | 2017-03-03 | Icim Int S R L | Antioxidant association and compositions containing it. |
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Application publication date: 20110427 Assignee: CHENGDU YONGAN YUANHE BIOTECHNOLOGY CO., LTD. Assignor: Jiangnan University Contract record no.: 2015510000018 Denomination of invention: Health care product auxiliary material and application thereof Granted publication date: 20141210 License type: Exclusive License Record date: 20150324 |
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