CN101983714A - Traditional Chinese medicine composition for treating angina and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating angina and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine preparation, in particular to a traditional Chinese medicine composition for treating angina and a preparation method thereof. The invention is characterized in that the composition is prepared by the following traditional Chinese medicine raw materials by parts by weight: 1-5 parts of milkvetch root, 1-5 parts of codonopsis pilosula, 5-10 parts of epimedium, 2-8 parts of cyperus rotundus, 5-10 parts of eucommia bark, 15-25 parts of prepared rhizome of rehmannia, 5-15 parts of barbary wolfberry fruit, 5-10 parts of cassia twig, 3-8 parts of roasted liquorice, 5-15 parts of Szechwan lovage rhizome and 5-10 parts of turmeric tablets. The composition has the effects of warming kidney and replenishing qi as well as promoting coronary circulation, curative effect on angina is good, no toxic or side effect is produced, and safety is high.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, particularly a kind of treatment angina pectoris Chinese medicine composition and preparation method thereof.
Background technology
Angina pectoris is a coronary insufficiency, and rapid, the temporary transient ischemia of cardiac muscle is caused with anoxia to be the clinical syndrome that mainly shows with ictal chest pain or chest discomfort.Its characteristics are paroxysmal shirtfront squeezing property pain perception, can be with other symptoms, pain mainly is positioned at the breastbone rear portion, can be radiated to pareordia and left upper extremity, often betide work or when excited, the 3～5min that at every turn shows effect, but a few days is once, also can one day for several times, have a rest or with disappearing behind the nitrate preparations.Primary disease is more common in the male, and most patients are more than 40 years old, tired, excited, be satiated with food, catch cold, rainy weather, acute circulatory failure etc. are common inducement.
The traditional Chinese medical science is thought: angina pectoris belongs to the traditional Chinese medical science " thoracic obstruction " and " pained " category, is more common in middle-aged and elderly people clinically in recent years, and the disease being located in the heart is dirty relevant with Liver and kidney three with spleen.The traditional Chinese medical science is thought " man-year 40, half of YIN QI consumed ", and kidney qi is empty, agitates the power deficiency of blood vessels operation, in the body the existing blood walking retardation in children slow, accumulatively wet raise phlegm, the stasis of blood and obstructed gesture, this is the prerequisite and the basis of primary disease generation.Treatment in clinical center angor stage of attack should be from invigorating the spleen for dissipating phlegm, blood circulation promoting and blood stasis dispelling, and liver-smoothing, qi-regulating is started with.
Summary of the invention
The object of the present invention is to provide a kind of anginal Chinese medicine composition and preparation method thereof, this medicine the kidney warming QI invigorating, blood circulation and channel invigorating is applicable to the angina pectoris of yang hyperactivity stasis.Its therapeutic effect is good, and is safe.
Another object of the present invention is to provide the preparation method of this Chinese medicine composition.
The present invention also aims to the application of this Chinese medicine composition in the anginal medicine of preparation treatment.
Technical scheme of the present invention is: the anginal Chinese medicine composition of a kind of treatment, it is characterized in that: the raw material of Chinese medicine medicine by following weight parts is formulated: Radix Astragali 1-5 part, Radix Codonopsis 1-5 part, Herba Epimedii 5-10 part, Rhizoma Cyperi 2-8 part, Cortex Eucommiae 5-10 part, Radix Rehmanniae Preparata 15-25 part, Fructus Lycii 5-15 part, Ramulus Cinnamomi 5-10 part, Radix Glycyrrhizae Preparata 3-8 part, Rhizoma Chuanxiong 5-15 part, Rhizoma Curcumae Longae sheet 5-10 part
Described a kind of weight portion for the treatment of anginal Chinese medicine composition is: 2 parts of the Radixs Astragali, 2 parts of Radix Codonopsis, 8 parts of Herba Epimedii, 6 parts of Rhizoma Cyperi, 8 parts of the Cortexs Eucommiae, 20 parts in Radix Rehmanniae Preparata, 10 parts of Fructus Lycii, 8 parts of Ramulus Cinnamomi, 5 parts of Radix Glycyrrhizae Preparatas, 10 parts of Rhizoma Chuanxiongs, 8 parts of Rhizoma Curcumae Longae sheets
Described a kind of weight portion for the treatment of anginal Chinese medicine composition is: 1 part of the Radix Astragali, 2 parts of Radix Codonopsis, 5 parts of Herba Epimedii, 2 parts of Rhizoma Cyperi, 5 parts of the Cortexs Eucommiae, 15 parts in Radix Rehmanniae Preparata, 5 parts of Fructus Lycii, 5 parts of Ramulus Cinnamomi, 3 parts of Radix Glycyrrhizae Preparatas, 5 parts of Rhizoma Chuanxiongs, 5 parts of Rhizoma Curcumae Longae sheets
Described a kind of weight portion for the treatment of anginal Chinese medicine composition is: 5 parts of the Radixs Astragali, 5 parts of Radix Codonopsis, 10 parts of Herba Epimedii, 8 parts of Rhizoma Cyperi, 10 parts of the Cortexs Eucommiae, 25 parts in Radix Rehmanniae Preparata, 15 parts of Fructus Lycii, 10 parts of Ramulus Cinnamomi, 8 parts of Radix Glycyrrhizae Preparatas, 15 parts of Rhizoma Chuanxiongs, 10 parts of Rhizoma Curcumae Longae sheets
The present invention also provides the preparation method of above-mentioned Chinese medicine composition, comprises the steps:
1) crude drug of getting in the above-mentioned raw materials carries out roguing respectively, and clean, dry, standby;
2) in the above raw material, the Radix Astragali, Radix Codonopsis, Herba Epimedii are ground into coarse powder, Rhizoma Cyperi, the Cortex Eucommiae, Radix Rehmanniae Preparata, Fructus Lycii, Ramulus Cinnamomi, Radix Glycyrrhizae Preparata, Rhizoma Chuanxiong, the fragmentation of Rhizoma Curcumae Longae sheet, Rhizoma Chuanxiong, the Rhizoma Curcumae Longae sheet is ground into fine powder, and is standby;
3) add the Cortex Eucommiae, Radix Rehmanniae Preparata, Fructus Lycii, Ramulus Cinnamomi, the 65-85% ethanol that the 6-10 of weight doubly measures, heating (65 ℃ of temperature) reflux, extract, 2-4 time was extracted 1-2 hour at every turn, filtered, merging filtrate reclaims ethanol, and in 50-70 ℃ of thick paste that is concentrated into relative density 1.10-1.30;
4) thick paste that step 3) is obtained adds ethanol (concentration of alcohol 95%) eluting, and the limit edged stirs, and precipitation adds ethanol elution 3-5 time, and the total ethanol consumption is 6-10 a times of thick paste amount, places a moment, merges supernatant, and is standby;
5) add the 65-85% ethanol that the 6-10 of the Radix Astragali, Radix Codonopsis, Herba Epimedii coarse powder weight doubly measures, heating (65 ℃ of temperature) reflux, extract, 2-4 time, the each extraction 1-2 hour, filter, the supernatant that filtrate and step 4) obtain merges, reclaim ethanol, and in 50-70 ℃ of thick paste that is concentrated into relative density 1.30-1.32;
6) add Radix Glycyrrhizae Preparata, Rhizoma Chuanxiong, the 65-85% ethanol that the 8-12 of Rhizoma Curcumae Longae sheet weight doubly measures, heating (65 ℃ of temperature) reflux, extract, 1-3 time was extracted 1-2 hour at every turn, filtered, merging filtrate reclaims ethanol, and in 50-70 ℃ of thick paste that is concentrated into relative density 1.30-1.32;
7) thick paste that obtains of thick paste that step 4) is obtained and step 3) merges, and drying is ground into fine powder, and mixing is made described Chinese medicine composition.
Described fine powder all can pass through 100 mesh sieves, wherein is no less than 95% and can passes through 120 mesh sieves.
In the above-mentioned preparation method, the best thickening temperature of step 3), step 5) and step 6) is 60 ℃.
Preparation of the present invention is peroral dosage form preferably, as: capsule, tablet, oral liquid, granule, pill, powder, sublimed preparation unguentum etc., more preferably capsule.Preparation of the present invention is determined usage and dosage according to patient's situation in use.
Every of this medicament specification contains active ingredient 0.3g, an oral 4-5 grain, and 3 times on the 1st, serveing on for 4 weeks was 1 course of treatment
Chinese medicine composition of the present invention is the Radix Astragali, Radix Codonopsis, Herba Epimedii, Rhizoma Cyperi, the Cortex Eucommiae, Radix Rehmanniae Preparata, Fructus Lycii, Ramulus Cinnamomi, it is sweet to process,, Rhizoma Chuanxiong, Rhizoma Curcumae Longae sheet, be clinical treatment experience and verification experimental verification and prescription, this medicine has the kidney warming QI invigorating, the effect of blood circulation and channel invigorating." book on Chinese herbal medicine meets former " carries that " Radix Astragali can all void of tonifying five ZANG-organs, controls the stringy pulse spontaneous perspiration, rushes down YIN-fire, removes lung-heat, losslessly then sends out, and has antiperspirant then to end." " book on Chinese herbal medicine justice ": Radix Codonopsis power energy spleen reinforcing nourishing the stomach, the lung moistening and production of body fluid promoting, gas in the tendon fortune, this is very mutually not far away with Radix Ginseng; Herba Epimedii [function cures mainly] kidney invigorating and YANG supporting, expelling wind and removing dampness.Control the sexual impotence erectile problem, dribbling urination, the muscles and bones contraction is anxious, hemiplegia, weakness of the waist and knees, rheumatic arthralgia, extremity are meciless.Rhizoma Cyperi [function cures mainly] resolving depression of regulating the flow of vital energy, menstruction regulating and pain relieving; The invigorating the liver and kidney of Cortex Eucommiae tool, bone and muscle strengthening, blood pressure lowering, many effects such as antiabortive.Shennong's Herbal is classified as top grade.Radix Rehmanniae Preparata [effect] yin nourishing of enriching blood, life essence-filling, marrow-benefitting.; " book on Chinese herbal medicine is just ": Fructus Lycii, highly seasoned and pure, so the energy nourishing YIN has sun in the moon, so can QI invigorating." book on Chinese herbal medicine converge with speech ": Ramulus Cinnamomi, dispersing wind and cold by pathogenic factor in the exterior, sends out antiperspirant evil, and cough-relieving is coughed, and the medicine that goes wind pain between podomere is also.Rhizoma Chuanxiong effect: blood circulation promoting and blood stasis dispelling; Activating QI to alleviate the depression; Wind-expelling pain-stopping; Rhizoma Curcumae Longae sheet function cures mainly circulation of qi promoting removing blood stasis with potent drugs, inducing menstruation to relieve menalgia.
The specific embodiment
Below by the specific embodiment that provides the present invention is described clearly further, but not as a limitation of the invention.
Embodiment 1
Described a kind of weight portion for the treatment of anginal Chinese medicine composition is: 2 parts of the Radixs Astragali, 2 parts of Radix Codonopsis, 8 parts of Herba Epimedii, 6 parts of Rhizoma Cyperi, 8 parts of the Cortexs Eucommiae, 20 parts in Radix Rehmanniae Preparata, 10 parts of Fructus Lycii, 8 parts of Ramulus Cinnamomi, 5 parts of Radix Glycyrrhizae Preparatas, 10 parts of Rhizoma Chuanxiongs, 8 parts of Rhizoma Curcumae Longae sheets
The present invention also provides the preparation method of above-mentioned Chinese medicine composition, comprises the steps:
1) crude drug of getting in the above-mentioned raw materials carries out roguing respectively, and clean, dry, standby;
2) in the above 3 flavor raw materials, the Radix Astragali, Radix Codonopsis, Herba Epimedii are ground into coarse powder, Rhizoma Cyperi, the Cortex Eucommiae, Radix Rehmanniae Preparata, Fructus Lycii, Ramulus Cinnamomi, Radix Glycyrrhizae Preparata, Rhizoma Chuanxiong, the fragmentation of Rhizoma Curcumae Longae sheet, Rhizoma Chuanxiong, the Rhizoma Curcumae Longae sheet is ground into fine powder, and is standby;
3) add the Cortex Eucommiae, Radix Rehmanniae Preparata, Fructus Lycii, Ramulus Cinnamomi, the 65-85% ethanol that the 6-10 of weight doubly measures, heating (65 ℃ of temperature) reflux, extract, 2-4 time was extracted 1-2 hour at every turn, filtered, merging filtrate reclaims ethanol, and in 50-70 ℃ of thick paste that is concentrated into relative density 1.10-1.30;
4) thick paste that step 3) is obtained adds ethanol (concentration of alcohol 95%) eluting, and the limit edged stirs, and precipitation adds ethanol elution 3-5 time, and the total ethanol consumption is 6-10 a times of thick paste amount, places a moment, merges supernatant, and is standby;
5) add the 65-85% ethanol that the 6-10 of the Radix Astragali, Radix Codonopsis, Herba Epimedii coarse powder weight doubly measures, heating (65 ℃ of temperature) reflux, extract, 2-4 time, the each extraction 1-2 hour, filter, the supernatant that filtrate and step 4) obtain merges, reclaim ethanol, and in 50-70 ℃ of thick paste that is concentrated into relative density 1.30-1.32;
6) add Radix Glycyrrhizae Preparata, Rhizoma Chuanxiong, the 65-85% ethanol that the 8-12 of Rhizoma Curcumae Longae sheet weight doubly measures, heating (65 ℃ of temperature) reflux, extract, 1-3 time was extracted 1-2 hour at every turn, filtered, merging filtrate reclaims ethanol, and in 50-70 ℃ of thick paste that is concentrated into relative density 1.30-1.32;
7) thick paste that obtains of thick paste that step 4) is obtained and step 3) merges, and drying is ground into fine powder, and mixing is made described Chinese medicine composition.
Embodiment 2
1 part of the Radix Astragali, 2 parts of Radix Codonopsis, 5 parts of Herba Epimedii, 2 parts of Rhizoma Cyperi, 5 parts of the Cortexs Eucommiae, 15 parts in Radix Rehmanniae Preparata, 5 parts of Fructus Lycii, 5 parts of Ramulus Cinnamomi, 3 parts of Radix Glycyrrhizae Preparatas, 5 parts of Rhizoma Chuanxiongs, 5 parts of Rhizoma Curcumae Longae sheets
Preparation method is with embodiment 1
1) crude drug of getting in the above-mentioned raw materials carries out roguing respectively, and clean, dry, standby;
2) in the above 3 flavor raw materials, the Radix Astragali, Radix Codonopsis, Herba Epimedii are ground into coarse powder, Rhizoma Cyperi, the Cortex Eucommiae, Radix Rehmanniae Preparata, Fructus Lycii, Ramulus Cinnamomi, Radix Glycyrrhizae Preparata, Rhizoma Chuanxiong, the fragmentation of Rhizoma Curcumae Longae sheet, Rhizoma Chuanxiong, the Rhizoma Curcumae Longae sheet is ground into fine powder, and is standby;
3) add the Cortex Eucommiae, Radix Rehmanniae Preparata, Fructus Lycii, Ramulus Cinnamomi, the 65-85% ethanol that the 6-10 of weight doubly measures, heating (65 ℃ of temperature) reflux, extract, 2-4 time was extracted 1-2 hour at every turn, filtered, merging filtrate reclaims ethanol, and in 50-70 ℃ of thick paste that is concentrated into relative density 1.10-1.30;
4) thick paste that step 3) is obtained adds ethanol (concentration of alcohol 95%) eluting, and the limit edged stirs, and precipitation adds ethanol elution 3-5 time, and the total ethanol consumption is 6-10 a times of thick paste amount, places a moment, merges supernatant, and is standby;
5) add the 65-85% ethanol that the 6-10 of the Radix Astragali, Radix Codonopsis, Herba Epimedii coarse powder weight doubly measures, heating (65 ℃ of temperature) reflux, extract, 2-4 time, the each extraction 1-2 hour, filter, the supernatant that filtrate and step 4) obtain merges, reclaim ethanol, and in 50-70 ℃ of thick paste that is concentrated into relative density 1.30-1.32;
6) add Radix Glycyrrhizae Preparata, Rhizoma Chuanxiong, the 65-85% ethanol that the 8-12 of Rhizoma Curcumae Longae sheet weight doubly measures, heating (65 ℃ of temperature) reflux, extract, 1-3 time was extracted 1-2 hour at every turn, filtered, merging filtrate reclaims ethanol, and in 50-70 ℃ of thick paste that is concentrated into relative density 1.30-1.32;
7) thick paste that obtains of thick paste that step 4) is obtained and step 3) merges, and drying is ground into fine powder, and mixing is made described Chinese medicine composition.
Embodiment 3
5 parts of the Radixs Astragali, 5 parts of Radix Codonopsis, 10 parts of Herba Epimedii, 8 parts of Rhizoma Cyperi, 10 parts of the Cortexs Eucommiae, 25 parts in Radix Rehmanniae Preparata, 15 parts of Fructus Lycii, 10 parts of Ramulus Cinnamomi, 8 parts of Radix Glycyrrhizae Preparatas, 15 parts of Rhizoma Chuanxiongs, 10 parts of Rhizoma Curcumae Longae sheets
Preparation method is with embodiment 1
1) crude drug of getting in the above-mentioned raw materials carries out roguing respectively, and clean, dry, standby;
2) in the above 3 flavor raw materials, the Radix Astragali, Radix Codonopsis, Herba Epimedii are ground into coarse powder, Rhizoma Cyperi, the Cortex Eucommiae, Radix Rehmanniae Preparata, Fructus Lycii, Ramulus Cinnamomi, Radix Glycyrrhizae Preparata, Rhizoma Chuanxiong, the fragmentation of Rhizoma Curcumae Longae sheet, Rhizoma Chuanxiong, the Rhizoma Curcumae Longae sheet is ground into fine powder, and is standby;
3) add the Cortex Eucommiae, Radix Rehmanniae Preparata, Fructus Lycii, Ramulus Cinnamomi, the 65-85% ethanol that the 6-10 of weight doubly measures, heating (65 ℃ of temperature) reflux, extract, 2-4 time was extracted 1-2 hour at every turn, filtered, merging filtrate reclaims ethanol, and in 50-70 ℃ of thick paste that is concentrated into relative density 1.10-1.30;
4) thick paste that step 3) is obtained adds ethanol (concentration of alcohol 95%) eluting, and the limit edged stirs, and precipitation adds ethanol elution 3-5 time, and the total ethanol consumption is 6-10 a times of thick paste amount, places a moment, merges supernatant, and is standby;
5) add the 65-85% ethanol that the 6-10 of the Radix Astragali, Radix Codonopsis, Herba Epimedii coarse powder weight doubly measures, heating (65 ℃ of temperature) reflux, extract, 2-4 time, the each extraction 1-2 hour, filter, the supernatant that filtrate and step 4) obtain merges, reclaim ethanol, and in 50-70 ℃ of thick paste that is concentrated into relative density 1.30-1.32;
6) add Radix Glycyrrhizae Preparata, Rhizoma Chuanxiong, the 65-85% ethanol that the 8-12 of Rhizoma Curcumae Longae sheet weight doubly measures, heating (65 ℃ of temperature) reflux, extract, 1-3 time was extracted 1-2 hour at every turn, filtered, merging filtrate reclaims ethanol, and in 50-70 ℃ of thick paste that is concentrated into relative density 1.30-1.32;
7) thick paste that obtains of thick paste that step 4) is obtained and step 3) merges, and drying is ground into fine powder, and mixing is made described Chinese medicine composition.
More than the effect of renting a house of three embodiment be more significant prescription, but so long as comparatively significantly curative effect, Radix Astragali 1-5 part, Radix Codonopsis 1-5 part, Herba Epimedii 5-10 part all can be arranged by following prescription proportioning, Rhizoma Cyperi 2-8 part, Cortex Eucommiae 5-10 part, Radix Rehmanniae Preparata 15-25 part, Fructus Lycii 5-15 part, Ramulus Cinnamomi 5-10 part, Radix Glycyrrhizae Preparata 3-8 part, Rhizoma Chuanxiong 5-15 part, Rhizoma Curcumae Longae sheet 5-10 part
The umber of Chinese medicine component can be got gram (g), kilogram (kg), ton (t).
In order to show the therapeutic effect of medicine of the present invention, the present invention has carried out clinical trial:
A kind of clinical experiment for the treatment of anginal Chinese medicine composition proposed by the invention is as follows: select age 38-55 year patient 45 examples, 47 years old mean age, course of disease May-15 month, average course of disease 8 months.The patient did not accept other treatment before this treatment.28 days is a course of treatment, carries out symptom score after 28 days.Among the 45 routine patients, 15 examples (being called the treatment group) take capsule of the present invention (specification: the 0.3g/ grain), each 4-5 grain, every day 3 times; 15 examples (being called contrast A group) are regularly taken Propranolol; 15 examples (being called contrast B group) are taken nitroglycerin.The patient discontinues the habit of smoking and drinking during this time, is careful in one's diet and has a rest.
Therapeutic outcome:
Treat after 20 days, therapeutic effect relatively sees Table 1.
Table 1 capsule for treating of the present invention is the effect comparison after 28 days
| Group | The N number | Effectively | 28 days effective percentage (%) | Side effect |
| The treatment group | 15 | 14 | 93.3% | 0 |
| Contrast A group | 15 | 12 | 80% | 11 |
| Contrast B group | 15 | 14 | 93.3% | 8 |
By table 1 as seen, the effective percentage that uses the made capsular treatment group of the present invention is apparently higher than contrast A group, and the effective percentage of treatment group equals to contrast the B group, and the side effect example is several then to be zero, and side effect all appears in contrast A group and contrast B group.The result shows the good effect of using the made capsular treatment group of the present invention, has no side effect.
In addition, use the made capsule of the present invention, medical expense is starkly lower than matched group.
Claims (5)
1. treat anginal Chinese medicine composition for one kind, it is characterized in that: the raw material of Chinese medicine medicine by following weight parts is formulated:
Radix Astragali 1-5 part, Radix Codonopsis 1-5 part, Herba Epimedii 5-10 part, Rhizoma Cyperi 2-8 part, Cortex Eucommiae 5-10 part, Radix Rehmanniae Preparata 15-25 part, Fructus Lycii 5-15 part, Ramulus Cinnamomi 5-10 part, Radix Glycyrrhizae Preparata 3-8 part, Rhizoma Chuanxiong 5-15 part, Rhizoma Curcumae Longae sheet 5-10 part.
2. according to the anginal Chinese medicine composition of the described a kind of treatment of claim 1, it is characterized in that: its weight portion is 1 part of the Radix Astragali, 2 parts of Radix Codonopsis, 5 parts of Herba Epimedii, 2 parts of Rhizoma Cyperi, 5 parts of the Cortexs Eucommiae, 15 parts in Radix Rehmanniae Preparata, 5 parts of Fructus Lycii, 5 parts of Ramulus Cinnamomi, 3 parts of Radix Glycyrrhizae Preparatas, 5 parts of Rhizoma Chuanxiongs, 5 parts of Rhizoma Curcumae Longae sheets.
3. according to the anginal Chinese medicine composition of the described a kind of treatment of claim 1, it is characterized in that: its weight portion is 2 parts of the Radixs Astragali, 2 parts of Radix Codonopsis, 8 parts of Herba Epimedii, 6 parts of Rhizoma Cyperi, 8 parts of the Cortexs Eucommiae, 20 parts in Radix Rehmanniae Preparata, 10 parts of Fructus Lycii, 8 parts of Ramulus Cinnamomi, 5 parts of Radix Glycyrrhizae Preparatas, 10 parts of Rhizoma Chuanxiongs, 8 parts of Rhizoma Curcumae Longae sheets.
4. according to the anginal Chinese medicine composition of the described a kind of treatment of claim 1, it is characterized in that: its weight portion is 5 parts of the Radixs Astragali, 5 parts of Radix Codonopsis, 10 parts of Herba Epimedii, 8 parts of Rhizoma Cyperi, 10 parts of the Cortexs Eucommiae, 25 parts in Radix Rehmanniae Preparata, 15 parts of Fructus Lycii, 10 parts of Ramulus Cinnamomi, 8 parts of Radix Glycyrrhizae Preparatas, 15 parts of Rhizoma Chuanxiongs, 10 parts of Rhizoma Curcumae Longae sheets.
5. according to the described a kind of preparation method for the treatment of anginal Chinese medicine composition of claim 1-4, comprise the steps:
1) crude drug of getting in the above-mentioned raw materials carries out roguing respectively, and clean, dry, standby;
2), in the above raw material, the Radix Astragali, Radix Codonopsis, Herba Epimedii are ground into coarse powder, Rhizoma Cyperi, the Cortex Eucommiae, Radix Rehmanniae Preparata, Fructus Lycii, Ramulus Cinnamomi, Radix Glycyrrhizae Preparata, Rhizoma Chuanxiong, the fragmentation of Rhizoma Curcumae Longae sheet, Rhizoma Chuanxiong, the Rhizoma Curcumae Longae sheet is ground into fine powder, and is standby;
3), add the Cortex Eucommiae, Radix Rehmanniae Preparata, Fructus Lycii, Ramulus Cinnamomi, the 65-85% ethanol that the 6-10 of weight doubly measures, heating (65 ℃ of temperature) reflux, extract, 2-4 time was extracted 1-2 hour at every turn, filtered, merging filtrate reclaims ethanol, and in 50-70 ℃ of thick paste that is concentrated into relative density 1.10-1.30;
4), thick paste that step 3) is obtained adds ethanol (concentration of alcohol 95%) eluting, the limit edged stirs, precipitation adds ethanol elution 3-5 time, the total ethanol consumption be the thick paste amount 6-10 doubly, place a moment, the merging supernatant, standby;
5), add the 65-85% ethanol that the 6-10 of the Radix Astragali, Radix Codonopsis, Herba Epimedii coarse powder weight doubly measures, heating (65 ℃ of temperature) reflux, extract, 2-4 time, the each extraction 1-2 hour, filter, the supernatant that filtrate and step 4) obtain merges, reclaim ethanol, and in 50-70 ℃ of thick paste that is concentrated into relative density 1.30-1.32;
6), add Radix Glycyrrhizae Preparata, Rhizoma Chuanxiong, the 65-85% ethanol that the 8-12 of Rhizoma Curcumae Longae sheet weight doubly measures, heating (65 ℃ of temperature) reflux, extract, 1-3 time was extracted 1-2 hour at every turn, filtered, merging filtrate reclaims ethanol, and in 50-70 ℃ of thick paste that is concentrated into relative density 1.30-1.32;
7), the thick paste that obtains of thick paste that step 4) is obtained and step 3) merges, drying is ground into fine powder, mixing is made described Chinese medicine composition;
Described fine powder all can pass through 100 mesh sieves, wherein is no less than 95% and can passes through 120 mesh sieves;
In the above-mentioned preparation method, the best thickening temperature of step 3), step 5) and step 6) is 60 ℃.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102698236A (en) * | 2012-06-15 | 2012-10-03 | 李良 | Codonopsis pilosula traditional Chinese medicine decoction for treating abdominal pain and preparation method for decoction |
| CN105267690A (en) * | 2015-03-17 | 2016-01-27 | 孔冬梅 | Traditional Chinese medicine for treating angina pectoris |
| CN107714849A (en) * | 2017-11-16 | 2018-02-23 | 广西***华春福家庭农场 | A kind of Chinese medicine composition for treating myocardial ischemia and preparation method thereof |
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2010
- 2010-11-08 CN CN2010105348018A patent/CN101983714A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102698236A (en) * | 2012-06-15 | 2012-10-03 | 李良 | Codonopsis pilosula traditional Chinese medicine decoction for treating abdominal pain and preparation method for decoction |
| CN102698236B (en) * | 2012-06-15 | 2013-12-25 | 李良 | Codonopsis pilosula traditional Chinese medicine decoction for treating abdominal pain and preparation method for decoction |
| CN105267690A (en) * | 2015-03-17 | 2016-01-27 | 孔冬梅 | Traditional Chinese medicine for treating angina pectoris |
| CN107714849A (en) * | 2017-11-16 | 2018-02-23 | 广西***华春福家庭农场 | A kind of Chinese medicine composition for treating myocardial ischemia and preparation method thereof |
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Application publication date: 20110309 |