CN101983685A - Traditional Chinese medicine composition for treating qi-asthenia cough and preparation method thereof - Google Patents

Abstract

The invention relates to an oral traditional Chinese medicine preparation, in particular to a traditional Chinese medicine composition for treating qi-asthenia cough and a preparation method thereof. The composition is characterized by being prepared from the following traditional Chinese medicines by weight: 5-15 parts of processed pinellia, 10-20 parts of tussilago, 10-20 parts of unibract fritillary bulb, 10-20 parts of tangerine peel, 5-15 parts of gingko, 3-15 parts of fructus aurantii, 5-15 parts of cortex mori radicis, 3-10 parts of perillaseed, 5-12 parts of processed ephedra and 8-20 parts of lily. The composition can rapidly relieve pain, has the functions of diminishing inflammation and dissipating blood stasis, has confirmed curative effect on treating qi-asthenia cough and has no toxic or side effects.

Description

A kind of Chinese medicine composition for the treatment of the qi-asthenia cough and preparation method thereof

Technical field

The present invention relates to a kind of oral Chinese medicine preparation, particularly a kind of Chinese medicine composition for the treatment of the qi-asthenia cough and preparation method thereof.

Background technology

The qi-asthenia cough, the cough that the deficiency of vital energy causes.Many because of overworking, lung qi has wound; Or improper diet and overtiredness, middle gas diminishes,, due to the inability of earth to generate metal.Disease is met yellow leanness, timidness due to deficiency of QI god from, cough is spat, the expectorant color is rare clearly, diet reduces.The lung being damaged by lasted cough or weak usually, insufficiency of lung-QI, or insufficiency of the spleen fortuneization is strong, essence of water and grain can not be gone up flourish in lung, then lung qi day void.Waste gas loss, respectful fall mistake department then cough, low voice, breathe hard.So the insufficiency of lung-QI weakened defensive QI is anemophobia, spontaneous perspiration, easy catching a cold; Mental fatigue, pale tongue with white fur, weak pulse are resembling of the deficiency of vital energy.The western medicine toxic and side effects that adopts is bigger at present, and can not dig up the roots; And common Chinese Traditional Medicines curative effect is all definite inadequately, and it is rapid inadequately to take effect.

Summary of the invention

The object of the present invention is to provide Chinese medicine composition of a kind of qi-asthenia cough of treatment and preparation method thereof, it can be behind oral this Chinese medicine composition of patient side effect little, good effect.

Technical scheme of the present invention is: a kind of qi-asthenia cough's of treatment oral Chinese medicine compositions is characterized in that: the raw material of Chinese medicine medicine by following weight parts is formulated:

Rhizoma Pinelliae Preparata 5-15 part, Flos Farfarae 10-20 part, Bulbus Fritillariae Cirrhosae 10-20 part, Pericarpium Citri Reticulatae 10-20 part, BAIGUO 5-15 part, Fructus Aurantii 3-15 part, Cortex Mori 5-15 part, CHAISUZI 3-10 part, system Herba Ephedrae 5-12 part, Bulbus Lilii 8-20 part.

The weight portion of described a kind of qi-asthenia cough's of treatment oral Chinese medicine compositions is: 10 parts of Rhizoma Pinelliae Preparata, 15 parts of Flos Farfaraees, 10 parts of Bulbus Fritillariae Cirrhosaes, 15 parts of Pericarpium Citri Reticulataes, 10 parts of BAIGUO, 8 parts of Fructus Aurantiis, 10 parts of Cortex Mori, 6 parts of CHAISUZI, 8 parts in Herba Ephedrae of system, 12 parts of Bulbus Liliies.

The weight portion of described a kind of qi-asthenia cough's of treatment oral Chinese medicine compositions is: 5 parts of Rhizoma Pinelliae Preparata, 10 parts of Flos Farfaraees, 10 parts of Bulbus Fritillariae Cirrhosaes, 10 parts of Pericarpium Citri Reticulataes, 5 parts of BAIGUO, 3 parts of Fructus Aurantiis, 5 parts of Cortex Mori, 3 parts of CHAISUZI, 5 parts in Herba Ephedrae of system, 8 parts of Bulbus Liliies.

The weight portion of described a kind of qi-asthenia cough's of treatment oral Chinese medicine compositions is: 15 parts of Rhizoma Pinelliae Preparata, 20 parts of Flos Farfaraees, 20 parts of Bulbus Fritillariae Cirrhosaes, 20 parts of Pericarpium Citri Reticulataes, 15 parts of BAIGUO, 15 parts of Fructus Aurantiis, 15 parts of Cortex Mori, 10 parts of CHAISUZI, 12 parts in Herba Ephedrae of system, 20 parts of Bulbus Liliies.

The present invention also provides the preparation method of above-mentioned Chinese medicine composition, comprises the steps:

1), the crude drug got in the above-mentioned raw materials carries out roguing respectively, and clean, dry, standby;

2), in the above raw material, Pericarpium Citri Reticulatae is ground into 100 order fine powders, standby;

3), all the other 9 kinds of crude drug are mixed, and the decocting that adds 10 times of amounts boils, and decocts 2 hours after-filtration, filtrate for later use;

4), the medicinal residues that step 3) the is obtained decocting that adds 8 times of amounts again boils 2 hours after-filtration, filtrate for later use;

5), with step 3), 4) filtrate that obtains mixing be incorporated in 60 ℃ and be evaporated to the thick paste that relative density is 1.25-1.28, and be standby;

6), with step 2) thick paste mix homogeneously that the fine powder that obtains and step 6) obtain, drying is ground into fine powder, makes described Chinese medicine composition.

Described fine powder all can pass through 100 mesh sieves, wherein is no less than 95% and can passes through 125 mesh sieves.

Preparation of the present invention is peroral dosage form preferably, as: capsule, tablet, oral liquid, granule, pill, powder, sublimed preparation unguentum etc., more preferably capsule.Preparation of the present invention is determined usage and dosage according to patient's situation in use.

Every of this medicament specification contains active ingredient 0.9g, oral one time 5,2 times on the 1st, serveing on for 4 weeks was 1 course of treatment.

Characteristics of the present invention are: this Chinese medicine composition contains Rhizoma Pinelliae Preparata, Flos Farfarae, Bulbus Fritillariae Cirrhosae, Pericarpium Citri Reticulatae, BAIGUO, Fructus Aurantii, Cortex Mori, CHAISUZI, system Herba Ephedrae, Bulbus Lilii.Be clinical treatment experience and verification experimental verification " herbal classic ": Rhizoma Pinelliae master typhoid fever cold and heat, hardness in the epigastrium, the therapeutic method to keep the adverse QI flowing downwards, laryngopharynx swells and ache, and the dizziness breast expands, cough with dyspnea, borborygmus, hidroschesis." property of medicine opinion ": it is short that the Flos Farfarae master treats the lung qi heart, and the weary labor of anxious heat is coughed repeatedly without ceasely, and tears saliva is sticky, controls consumptive lung disease lung abscess vomiting pus.

Bulbus Fritillariae Cirrhosae: Bulbus Fritillariae Cirrhosae hardship, clearing heat and moistening lung, preventing phlegm from forming and stopping coughing;

Pericarpium Citri Reticulatae: Pericarpium Citri Reticulatae is arduous, regulating qi-flowing for strengthening spleen, and in the accent, dampness is reduced phlegm;

BAIGUO: BAIGUO sweetness and bitterness, the solid lung of the kidney invigorating, sputum eliminating to stop asthma;

Fructus Aurantii: Fructus Aurantii bitter in the mouth, septum pectorale feeling of fullness, distending pain over the hypochondrium, accumulation of food in the stomach and intes tine due to indigestion;

Cortex Mori: Cortex Mori is sweet, eliminating pathogen from the lung for relieving asthma, inducing diuresis to remove edema;

CHAISUZI: the hot temperature of Fructus Perillae, the sending down the abnormal ascending QI expectorant is relievingd asthma, intestine moistening;

The system Herba Ephedrae: the Herba Ephedrae acrid in the mouth, the perspiration of inducing sweat, the fever of the body headache, wind and cold is dispersed;

Bulbus Lilii: Bulbus Lilii sweet in the mouth, nourishing YIN and moistening the lung, clearing away heart-fire for tranquillization;

The above-mentioned raw materials medicine is made mixing ratio respectively and is mixed together and boils drug effect and improve greatly, and can reduce the cough number of times fast.The effect that has invigorating the spleen and benefiting QI, tonifying the lung simultaneously, this medicine is used for the treatment of qi-asthenia cough's determined curative effect, has no side effect.

The specific embodiment

Below by the specific embodiment that provides the present invention is described clearly further, but not as a limitation of the invention.

Embodiment 1

The weight portion of described a kind of qi-asthenia cough's of treatment oral Chinese medicine compositions is: 10 parts of Rhizoma Pinelliae Preparata, 15 parts of Flos Farfaraees, 10 parts of Bulbus Fritillariae Cirrhosaes, 15 parts of Pericarpium Citri Reticulataes, 10 parts of BAIGUO, 8 parts of Fructus Aurantiis, 10 parts of Cortex Mori, 6 parts of CHAISUZI, 8 parts in Herba Ephedrae of system, 12 parts of Bulbus Liliies.

The present invention also provides the preparation method of above-mentioned Chinese medicine composition, comprises the steps:

1), the crude drug got in the above-mentioned raw materials carries out roguing respectively, and clean, dry, standby;

2), in the above raw material, Pericarpium Citri Reticulatae is ground into 100 order fine powders, standby;

3), all the other 9 kinds of crude drug are mixed, and the decocting that adds 10 times of amounts boils, and decocts 2 hours after-filtration, filtrate for later use;

4), the medicinal residues that step 3) the is obtained decocting that adds 8 times of amounts again boils 2 hours after-filtration, filtrate for later use;

5), with step 3), 4) filtrate that obtains mixing be incorporated in 60 ℃ and be evaporated to the thick paste that relative density is 1.25-1.28, and be standby;

6), with step 2) thick paste mix homogeneously that the fine powder that obtains and step 6) obtain, drying is ground into fine powder, makes described Chinese medicine composition.

Embodiment 2

The weight portion of described a kind of qi-asthenia cough's of treatment oral Chinese medicine compositions is: 5 parts of Rhizoma Pinelliae Preparata, 10 parts of Flos Farfaraees, 10 parts of Bulbus Fritillariae Cirrhosaes, 10 parts of Pericarpium Citri Reticulataes, 5 parts of BAIGUO, 3 parts of Fructus Aurantiis, 5 parts of Cortex Mori, 3 parts of CHAISUZI, 5 parts in Herba Ephedrae of system, 8 parts of Bulbus Liliies.

The present invention also provides the preparation method of above-mentioned Chinese medicine composition, comprises the steps:

1), the crude drug got in the above-mentioned raw materials carries out roguing respectively, and clean, dry, standby;

2), in the above raw material, Pericarpium Citri Reticulatae is ground into 100 order fine powders, standby;

3), all the other 9 kinds of crude drug are mixed, and the decocting that adds 10 times of amounts boils, and decocts 2 hours after-filtration, filtrate for later use;

4), the medicinal residues that step 3) the is obtained decocting that adds 8 times of amounts again boils 2 hours after-filtration, filtrate for later use;

5), with step 3), 4) filtrate that obtains mixing be incorporated in 60 ℃ and be evaporated to the thick paste that relative density is 1.25-1.28, and be standby;

6), with step 2) thick paste mix homogeneously that the fine powder that obtains and step 6) obtain, drying is ground into fine powder, makes described Chinese medicine composition.

Embodiment 3

The weight portion of described a kind of qi-asthenia cough's of treatment oral Chinese medicine compositions is: 15 parts of Rhizoma Pinelliae Preparata, 20 parts of Flos Farfaraees, 20 parts of Bulbus Fritillariae Cirrhosaes, 20 parts of Pericarpium Citri Reticulataes, 15 parts of BAIGUO, 15 parts of Fructus Aurantiis, 15 parts of Cortex Mori, 10 parts of CHAISUZI, 12 parts in Herba Ephedrae of system, 20 parts of Bulbus Liliies.

The present invention also provides the preparation method of above-mentioned Chinese medicine composition, comprises the steps:

1), the crude drug got in the above-mentioned raw materials carries out roguing respectively, and clean, dry, standby;

2), in the above raw material, Pericarpium Citri Reticulatae is ground into 100 order fine powders, standby;

3), all the other 9 kinds of crude drug are mixed, and the decocting that adds 10 times of amounts boils, and decocts 2 hours after-filtration, filtrate for later use;

4), the medicinal residues that step 3) the is obtained decocting that adds 8 times of amounts again boils 2 hours after-filtration, filtrate for later use;

5), with step 3), 4) filtrate that obtains mixing be incorporated in 60 ℃ and be evaporated to the thick paste that relative density is 1.25-1.28, and be standby;

6), with step 2) thick paste mix homogeneously that the fine powder that obtains and step 6) obtain, drying is ground into fine powder, makes described Chinese medicine composition.

More than the prescription effect of three embodiment be more significant prescription, but so long as by following prescription proportioning comparatively significantly curative effect can be arranged all, Rhizoma Pinelliae Preparata 5-15 part, Flos Farfarae 10-20 part, Bulbus Fritillariae Cirrhosae 10-20 part, Pericarpium Citri Reticulatae 10-20 part, BAIGUO 5-15 part, Fructus Aurantii 3-15 part, Cortex Mori 5-15 part, CHAISUZI 3-10 part, system Herba Ephedrae 5-12 part, Bulbus Lilii 8-20 part.

The umber of Chinese medicine component can be got gram (g), kilogram (kg), ton (t).

In order to show the therapeutic effect of medicine of the present invention, the present invention has carried out clinical trial.

The clinical trial of a kind of oral Chinese medicine compositions for the treatment of the qi-asthenia cough proposed by the invention is as follows: select age 18-40 year patient 48 examples, 30 years old mean age, course of disease 2-5, average course of disease 3 years.Patient's symptom is more serious, shortness of breath and fatigue person 20 people, and cough person 18 people, pulse condition valetudinarian, invalid 10 people, patient did not accept other treatment before this treatment.30 days is to carry out symptom score after 20 days courses of treatment.Among the 48 routine patients, 12 examples are as treatment group 1, and it adopts medicine of the present invention; Select 12 examples as treatment group 2 again, material component and treatment group 1 that treatment group 2 adopts are the same materials components, and production technology difference, treatment group 2 are first together the mixing together of all material components to be brewed into paste medicine; Select again 12 examples in contrast A group regularly eat SHENGMAI SAN; 12 examples (being called contrast B group) are with joining art cream; Be careful in one's diet during this time and have a rest.

Observational technique

1. observation index: the degree of 1. coughing, the time, the position, direction changes.2. simultaneous phenomenon (shortness of breath and fatigue, pulse condition weakness, abundant expectoration).3. the symptom influence factor waits variation;

2. efficacy determination: 1. clinical cure: symptom disappears substantially not to be had repeatedly.2. produce effects: cough is obviously alleviated, and simultaneous phenomenon disappears substantially or big portion alleviates, and meets the influence factor and does not have and increase the weight of.3. take a turn for the better: painful cough and simultaneous phenomenon alleviate, and then increase the weight of but meet the influence factor.4. invalid: all symptoms do not have to alleviate or have and increase the weight of trend.

Therapeutic outcome:

Treat after 5 days, therapeutic effect relatively sees Table 1.

Table 1 unguentum treatment of the present invention effect comparison after 20 days

Group	Number	Produce effects	Take a turn for the better	28 days effective percentage
					Treatment group 1	12	11	10	83.3%
Treatment group 2	12	11	9	75.0%
					Contrast A group	12	10	8	66.7%
Contrast B group	12	9	7	58.3%

By table 1 as seen, the effect of the treatment group 1 of the Chinese medicine that use the present invention is made is apparently higher than treatment group 2, illustrate that production technology has a significant impact therapeutic effect, the effect of treatment group 1 is apparently higher than contrast A group and contrast B group, and symptom takes a turn for the better apparently higher than using SHENGMAI SAN and ginseng art cream, the therapeutic effect that shows the powder that use the present invention is made is good, the obvious effective rate height.

Claims (5)

1. oral Chinese medicine compositions for the treatment of the qi-asthenia cough, it is characterized in that: the raw material of Chinese medicine medicine by following weight parts is formulated: Rhizoma Pinelliae Preparata 5-15 part, Flos Farfarae 10-20 part, Bulbus Fritillariae Cirrhosae 10-20 part, Pericarpium Citri Reticulatae 10-20 part, BAIGUO 5-15 part, Fructus Aurantii 3-15 part, Cortex Mori 5-15 part, CHAISUZI 3-10 part, system Herba Ephedrae 5-12 part, Bulbus Lilii 8-20 part.

2. according to the described a kind of oral Chinese medicine compositions for the treatment of the qi-asthenia cough of claim 1, it is characterized in that: its weight portion is: 10 parts of Rhizoma Pinelliae Preparata, 15 parts of Flos Farfaraees, 10 parts of Bulbus Fritillariae Cirrhosaes, 15 parts of Pericarpium Citri Reticulataes, 10 parts of BAIGUO, 8 parts of Fructus Aurantiis, 10 parts of Cortex Mori, 6 parts of CHAISUZI, 8 parts in Herba Ephedrae of system, 12 parts of Bulbus Liliies.

3. according to the described a kind of oral Chinese medicine compositions for the treatment of the qi-asthenia cough of claim 1, it is characterized in that: its weight portion is: 5 parts of Rhizoma Pinelliae Preparata, 10 parts of Flos Farfaraees, 10 parts of Bulbus Fritillariae Cirrhosaes, 10 parts of Pericarpium Citri Reticulataes, 5 parts of BAIGUO, 3 parts of Fructus Aurantiis, 5 parts of Cortex Mori, 3 parts of CHAISUZI, 5 parts in Herba Ephedrae of system, 8 parts of Bulbus Liliies.

4. according to the described a kind of oral Chinese medicine compositions for the treatment of the qi-asthenia cough of claim 1, it is characterized in that: its weight portion is: 15 parts of Rhizoma Pinelliae Preparata, 20 parts of Flos Farfaraees, 20 parts of Bulbus Fritillariae Cirrhosaes, 20 parts of Pericarpium Citri Reticulataes, 15 parts of BAIGUO, 15 parts of Fructus Aurantiis, 15 parts of Cortex Mori, 10 parts of CHAISUZI, 12 parts in Herba Ephedrae of system, 20 parts of Bulbus Liliies.

5. according to the described a kind of oral Chinese medicine preparation of compositions method for the treatment of the qi-asthenia cough of claim 1-4, comprise the steps:

1), the crude drug got in the above-mentioned raw materials carries out roguing respectively, and clean, dry, standby;

2), in the above raw material, Pericarpium Citri Reticulatae is ground into 100 order fine powders, standby;

3), all the other 9 kinds of crude drug are mixed, and the decocting that adds 10 times of amounts boils, and decocts 2 hours after-filtration, filtrate for later use;

4), the medicinal residues that step 3) the is obtained decocting that adds 8 times of amounts again boils 2 hours after-filtration, filtrate for later use;

5), with step 3), 4) filtrate that obtains mixing be incorporated in 60 ℃ and be evaporated to the thick paste that relative density is 1.25-1.28, and be standby;

6), with step 2) thick paste mix homogeneously that the fine powder that obtains and step 6) obtain, drying is ground into fine powder, makes described Chinese medicine composition.