CN101904911B - External application drug for treating eczema and preparation method thereof - Google Patents
External application drug for treating eczema and preparation method thereof Download PDFInfo
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Abstract
The invention discloses an external application drug for treating eczema and a preparation method thereof. Raw materials comprises the following components in parts by weight: 20-150 parts of borneol, 10-100 parts of common cnidium fruit, 10-130 parts of common fennel, 25-50 parts of indigo naturalis, 20-100 parts of subprostrate sophora, 5-50 parts of golden thread, 1-20 parts of pearl, 1-20 parts of bezoar, 1-20 parts of calcined depositum urinae hominis, 10-50 parts of gypsum rubrum, 100-300 parts of vaseline and 5-30 parts of wool oil. An ointment is prepared by mixing extracts of the subprostrate sophora, the golden thread, the common fennel and the gypsum rubrum and grinded powders of the borneol, the common cnidium fruit, the indigo naturalis, the pearl, the depositum urinae hominis and the artificial bezoar with blank substrates of the vaseline and wool oil cream. The traditional Chinese medicinal ointment for treating the eczema has the characteristics of exact efficacy, safety and convenience, small toxic and side-effect and low price.
Description
Technical field
The present invention relates to treat the medicine of eczema, particularly relate to a kind of treatment eczema effect medicine for external application and preparation method thereof.
Background technology
Dermatosis is in the majority with the inflammatory skin disease, and except that the minority inflammatory skin, the patient all has the pruritus of varying degree, and particularly modal dermatitis and eczema class dermatosis pruritus is particularly outstanding, seriously influences patient's physical and mental health.Eczema is a kind of common high dermis and epidermis inflammation.It possibly be since external physics, chemical irritation or Autosensitivity body constitution caused have an allergy scytitis that obviously oozes out tendency.Patient skin is often with pleomorphism, and acute pruritus shows effect repeatedly, is prone to be the chronic characteristic that turns to.Can be divided into acute, subacute and chronic three phases by its outbreak stage clinically.Different according to main skin lesion form, eczema erythematosum, blood rash property eczema, chickenpox property eczema, erosive eczema, abscess property eczema, eczemasquamosum etc. are then arranged.According to the difference of happening part, eczema capitis, facial eczema, ear eczema, eczema of nipple, omphalos eczema, clitoris eczema, anal eczema, hand eczema etc. are arranged then.
Chinese medicine thinks that eczema is not anti-because of natural disposition, and rheumatic fever visitor forms in skin; Or because of dysfunction of the spleen in transportation or nutrient QI and blood being insufficient, damp and hot staying, so that blood-deficiency and wind-dry are due to the damp and hot pent-up of wind-dryness, the failure of skin and muscle to be nourished.The many duties of eczema acute attack in the heart, subacute, chronic phase how duties in spleen, liver.Doctor trained in Western medicine thinks that the pathogenic factor of eczema is very complicated, and the interaction of intrinsic factor and extrinsic factor is arranged.Extrinsic factor such as living environment, weather conditions etc.Spirit such as intrinsic factor such as chronic digestive system disease, gastrointestinal function obstacle, psychentonia, insomnia, overwork, emotion changes changes, and infection focus, dysbolism and endocrine function imbalance etc. all can produce or add the state of an illness of celsus' papules.
Because doctor trained in Western medicine is unclear to the etiology and pathology of primary disease, so in treatment, lack etiological treatment measure and active drug, and bias toward anti symptom treatment, as avoid local excitation, application antihistaminic, topical application corticosteroid hormone class medicine such as are coated with outward at method.
At present, it is more to treat the method for eczema both at home and abroad.Like western medicine, medicine commonly used has vistaril, hismanal etc.; Like treatment by Chinese herbs, medicine commonly used has skin health lotion, skin-haemorrhoids-clearing etc.But the medicine of treatment eczema contains hormone more, and the side effect of this type medicine is big, and repeated multiple times is used; Erubescence appears easily, telangiectasis, xerosis cutis, coarse etc.; And changing steroid-dependent dermatitis into, treatment is got up more difficult, even some damaged skin can not recover normal forever.And also be difficult to the effect that reaches satisfied at aspects such as cure rate, medical expenses.Mainly adopt glucocorticoid to carry out external curing clinically.Though the glucocorticoid effect can be affirmed, side effect and drug resistance all more intense (Qiu Zhihui, Zhang Shouming ethoxy benzene willow amine Ointment in Treatment eczematous dermatitis class dermatosis observation of curative effect China leprosy dermatosis magazine (2003; 19 (5): 423); Like atrophoderma, pigment anomaly, telangiectasis; The secondary skin infection, glucocorticoid dependence dermatitis etc.After the drug withdrawal easy relapse in addition the time protopathy increase the weight of (Mao Changzhi, Zhou Xiaohong, Liu Zhihui, Xie Hong, Zhang Peilian. adverse effects of topical corticosteroids 420 example is analyzed clinical department of dermatologry magazine 1999,28 (6): 353-355)
Summary of the invention:
Medicine for external application of the treatment eczema of the purpose of this invention is to provide that a kind of safe ready, side effect are little, cost and cure rate are higher and preparation method thereof.
The object of the invention realizes through following technical scheme:
A kind of medicine for external application of treating eczema; Be ointment dosage form; By the extract of Radix Sophorae Tonkinensis, Rhizoma Coptidis, Radix Glycyrrhizae and Mirabilitum crystallina, Borneolum Syntheticum, Fructus Cnidii, Indigo Naturalis, Margarita, calamitas urinae hominis and artificial Calculus Bovis's abrasive flour is with the blank substrate mixing preparation formation of vaseline and lanoline emulsifiable paste; In parts by weight, raw material is made up of following component: 20～150 parts of Borneolum Syntheticums, 10～100 parts of Fructus Cnidiis, 10～130 parts in Radix Glycyrrhizae; 25～50 parts of Indigo Naturaliss, 20～100 parts of Radix Sophorae Tonkinensiss, 5～50 parts of Rhizoma Coptidis; 1～20 part of Margarita, 1～20 part of Calculus Bovis, 1～20 part of calcining calamitas urinae hominis; 10～50 parts of Mirabilitum crystallinas, 100～300 parts in vaseline, 5～30 parts of lanolines.
For further realizing the object of the invention, said Radix Sophorae Tonkinensis is 40～80 parts, and Rhizoma Coptidis is 15～40 parts, and Radix Glycyrrhizae is 50～100 parts, and Mirabilitum crystallina is 20～40 parts.
Said Borneolum Syntheticum is 60～110 parts, and Fructus Cnidii is 20～80 parts, and Indigo Naturalis is 30～50 parts, and Margarita is 5～10 parts, and the artificial Calculus Bovis is 5～10 parts, and the calcining calamitas urinae hominis is 10～20 parts.
Said vaseline is 150～250 parts, and lanoline is 10～20 parts.
The extract of Radix Sophorae Tonkinensis and Rhizoma Coptidis is an ethanol extraction; Radix Glycyrrhizae and Mirabilitum crystallina are water extract.
A kind of method for preparing that is used to treat the medicine for external application of eczema may further comprise the steps:
(1) presses composition of raw materials, get Radix Sophorae Tonkinensis and Rhizoma Coptidis powder is broken into powder, use alcohol reflux;
(2) press composition of raw materials, extracting liquorice and Mirabilitum crystallina are ground into powder, use water boiling and extraction;
(3) extracting solution of combining step (1) step (2), vacuum drying is pulverized the back mixing;
(4) with Borneolum Syntheticum 60～110 weight portions, Fructus Cnidii 20～80 weight portions, Indigo Naturalis 30～50 weight portions; Margarita 5～10 weight portions; Calculus Bovis 5～10 weight portions, calcining calamitas urinae hominis 10～20 weight portions, grind into powder; Add the extract of Radix Glycyrrhizae that (3) step obtains, Mirabilitum crystallina, Rhizoma Coptidis, Radix Sophorae Tonkinensis again, mixing sieves;
(5) vaseline and 10～20 weight portion lanolines with 150～250 weight portions are heated to 80 ℃ of fusions, are stirred to room temperature, stir, and obtain the blank substrate of emulsifiable paste;
In the homomixture that sieves of all medicines that (6) step (4) obtained, add in the barren ointment base, divide then to be filled in the bag.Every bag of 10g.
Described alcohol reflux is that to use weight concentration be 50%～70% alcohol reflux 2 times, extracts 1～3 hour at every turn, and amount of alcohol added is Radix Sophorae Tonkinensis and Rhizoma Coptidis powder 6～8 times for the first time; For the second time amount of alcohol added is Radix Sophorae Tonkinensis and Rhizoma Coptidis powder 4～6 times; Filter, merge extracted twice liquid, filtrating concentrates, and obtains in the time of 60 ℃ relative density and be 1.20～1.50 extractum.
Describedly be meant the decocte with water secondary with water boiling and extraction; The each decoction 1～3 hour, amount of water is Radix Glycyrrhizae and Mirabilitum crystallina weight 6～8 times for the first time, the second time, amount of water was Radix Glycyrrhizae and Mirabilitum crystallina weight 4～6 times; Filter; Merge to decoct filtrating, filtrating concentrates, and obtains in the time of 60 ℃ relative density and be 1.20～1.50 extractum.
Composition of raw materials of the present invention is made up of eight Chinese medicines such as Borneolum Syntheticum, Radix Glycyrrhizae, Indigo Naturalis, Radix Sophorae Tonkinensis, Rhizoma Coptidis, Margarita, artificial Calculus Bovis, calamitas urinae hominis and Mirabilitum crystallinas.Modern pharmacological research shows: not only heat-clearing and toxic substances removing, analgesia, antipruritic of Borneolum Syntheticum external in the side, its chemical constituent Borneolum Syntheticum and isoborneol have bacteriostasis, can suppress the growth of hog cholera vibrio, escherichia coli, staphylococcus aureus.Oozing out with inflammation such as tissue edemas of liquid all there is inhibitory action.Borneolum Syntheticum can also promote drug transdermal to absorb in addition, and the curative effect that improves medicine is had important effect.
Radix Glycyrrhizae contains glycyrrhizic acid, enoxolone, deoxidation glycyrrhizic acid, flavonoid etc. and participates in immunity, improves immunity, antiallergic, itching-relieving action.The property flat sweet in the mouth, have and middle emergency heat-clearing and toxic substances removing, antiallergic, antipruritic, blood circulation promoting and blood stasis dispelling, lung moistening, the effect of coordinating the actions of various ingredients in a prescription.
Indigo Naturalis have separate wet heat extraction, effects such as skin ulcer, blood cooling and ecchymoses removing are held back in detoxifcation; And it contains indigo more than 5%, thereby has bacteriostasis.The soak with ethanol liquid (0.5g/ml) of Indigo Naturalis, external all have inhibitory action to anthrax bacillus, dysentery bacterium, golden yellow Fructus Vitis viniferae bacillus etc.
Radix Sophorae Tonkinensis bitter in the mouth cold in nature, but heat-clearing and toxic substances removing, diseases such as reducing swelling and alleviating pain.It contains alkaloid, matrine, oxymatrine, anagyrine etc., and wherein matrine, oxymatrine have antitumor action, antiulcer action, and in addition, these article all have inhibitory action to staphylococcus aureus, acrothesium floccosum and Candida albicans.
Rhizoma Coptidis bitter in the mouth cold in nature, function heat clearing and damp drying, eliminating fire and detoxication.Can be used for acute conjunctivitis; Aphtha; Acute bacillary dysentery; Acute gastroenteritis etc., the root stock of Rhizoma Coptidis contains berberine, and berberine all has than the obvious suppression effect dysentery bacterium, bordetella pertussis, Bacillus typhi, tubercule bacillus, golden yellow Fructus Vitis viniferae bacillus, Hemolytic streptococcus, Diplococcus pneumoniae and Candida albicans.The methanol extract liquid of Rhizoma Coptidis is to rat ankle edema and Oleum Tiglii granulation capsule property inflammation etc., and topical also can make granuloma weight saving.And effects such as that berberine has is analgesic, diuresis, local anesthesia, calmness and analgesia.
Mirabilitum crystallina, Margarita be heat-clearing and toxic substances removing but also be rich in healing, the desalination pigment that various trace elements promotes the skin ulcer face through modern study not only.
Calamitas urinae hominis, artificial Calculus Bovis's heat-clearing and toxic substances removing, so this prescription has the effect of heat-clearing and toxic substances removing, blood cooling and ecchymoses removing, removing toxic substances and promoting granulation, reparation skin ulcer face.
Explanation to raw material used in the present invention does not show that medicine of the present invention is the simple combination of above-mentioned all medicines, and the effect that above-mentioned raw materials played among the present invention is comprehensive.
The Chinese herbal medicine each component that the present invention selects for use meets the regulation of The Drug Administration Law of People's Republic of China, utilizes the comprehensive function treatment eczema of the Chinese medicine of respectively distinguishing the flavor of, and is harmless to human non-toxic.Show that through the acute and chronic toxicity test of animal the animal of being tested does not see any toxic reaction, its main organs does not have tangible change yet, and safety of medicine is reliable.
Compared with prior art, present technique has following advantage:
(1) Chinese medicine composition composition of the present invention is simple, simple and convenient extraction, and medicament is easy to make, and is with low cost.Composition of raw materials of the present invention is made up of Borneolum Syntheticum, Radix Glycyrrhizae, Indigo Naturalis, Radix Sophorae Tonkinensis, Rhizoma Coptidis, Margarita, artificial Calculus Bovis, calamitas urinae hominis and Mirabilitum crystallina, and these medicines all are the Chinese medicine of using always, and cost is low, and preparation is convenient.
(2) the present invention adopts the Chinese crude drug of the different property of medicine, has carried out the science compatibility, can reach ideal therapeutic effect, and healing time is short, cures the back and is difficult for recurrence.Through eczema is treated confirmation, the present invention can effectively treat eczema, and treatment 1 week back treatment group cure rate surpasses 83%, and the cure rate of treatment two weeks back treatment group surpasses 89%, apparently higher than existing medicine.
(3) toxic and side effects of the present invention is little, shows that through the acute and chronic toxicity test of animal the animal of being tested does not see any toxic reaction, and its main organs does not have tangible change yet, and safety of medicine is reliable.
The specific embodiment
Below in conjunction with embodiment the present invention is further described, embodiments of the invention are not limited thereto.
Embodiment 1
Raw material configuration: Borneolum Syntheticum 70g, Fructus Cnidii 30g, Radix Glycyrrhizae 50g, Indigo Naturalis 30g, Radix Sophorae Tonkinensis 50g, Rhizoma Coptidis 20g, Margarita 5g, Calculus Bovis 5g, calcining calamitas urinae hominis 10g, Mirabilitum crystallina 20g.
Method for preparing comprises the steps:
(1) get Radix Sophorae Tonkinensis and Rhizoma Coptidis in the composition of raw materials, be ground into powder, using weight concentration is 50% alcohol reflux 2 times; The each extraction 1.5 hours, amount of alcohol added is 6 times of Radix Sophorae Tonkinensiss and Rhizoma Coptidis weight for the first time, amount of alcohol added is 4 times of Radix Sophorae Tonkinensiss and Rhizoma Coptidis weight for the second time; Filter, merge extracted twice liquid, filtrating concentrates; Obtain relative density in the time of 60 ℃ (relative density for respect to the mixed density of extracted twice liquid, down with) and be 1.30 extractum.
(2) get Radix Glycyrrhizae and Mirabilitum crystallina in the composition of raw materials, the decocte with water secondary decocted 1.5 hours at every turn; Amount of water is 6 times of Radix Glycyrrhizaes and Mirabilitum crystallina weight for the first time; Amount of water is 4 times of Radix Glycyrrhizaes and Mirabilitum crystallina weight for the second time, filters, and merges twice decoction filtrating; Filtrating concentrates, and obtains in the time of 60 ℃ relative density and be 1.30 extractum.
(3) two kinds of extractum of combining step (1) and step (2), vacuum drying is pulverized the back mixing.
(4) get Borneolum Syntheticum 70g, Indigo Naturalis 30g, Margarita 5g, Calculus Bovis 5g and calcining calamitas urinae hominis 10g grind into powder, add the extractum of Radix Glycyrrhizae that step (3) obtains, Mirabilitum crystallina, Rhizoma Coptidis, Radix Sophorae Tonkinensis again, mixing sieves.
(5) vaseline of 150g and the lanoline of 10g are heated to 80 ℃ of fusions, are stirred to room temperature, stir, obtain the blank substrate of emulsifiable paste;
(6) homomixture that sieves that step (4) is obtained joins in the blank substrate of step (5), and mixing divides to be filled in the bag then.Every ointment 10g.
Method for using: after each affected part cleaning, emulsifiable paste evenly is applied to the affected part, every day 1 time, a week is a course of treatment.
The treatment situation: choose 200 routine testing crews, wherein male 92 examples, women 108 examples, at 1 years old-70 years old age, the course of disease was observed within two weeks.In observing case, according to curative effect determinate standard, curative effect such as following table 1 and table 2.
Curative effect determinate standard:
A, healing: transference cure, the affected part clean dry does not have congested and rotten to the corn.
B, produce effects: transference cure, affected part still have mild hyperaemia, erosion.
C, improvement: symptom, sign are improved before the treatment.
D, invalid: symptom, sign do not have improvement.
Embodiment 2
Borneolum Syntheticum 90g, Fructus Cnidii 50g, Radix Glycyrrhizae 70g, Indigo Naturalis 40g, Radix Sophorae Tonkinensis 60g, Rhizoma Coptidis 30g, Margarita 8g, Calculus Bovis 7g, calcining calamitas urinae hominis 15g, Mirabilitum crystallina 30g.
Method for preparing: the Radix Sophorae Tonkinensis and the Rhizoma Coptidis of said weight portion got in (1), is ground into powder, the alcohol reflux with 60% 2 times; Each 2 hours, amount of alcohol added was 7 times of Radix Sophorae Tonkinensiss and Rhizoma Coptidis weight for the first time, and amount of alcohol added is 5 times of Radix Sophorae Tonkinensiss and Rhizoma Coptidis weight for the second time; Filter; Merge extractive liquid,, filtrating concentrates, and obtains in the time of 60 ℃ relative density and be 1.40 extractum;
(2) get the Radix Glycyrrhizae and the Mirabilitum crystallina of said weight portion, decocte with water secondary, each 2 hours; Amount of water is 7 times of Radix Glycyrrhizaes and Mirabilitum crystallina weight for the first time, and amount of water is 5 times of Radix Glycyrrhizaes and Mirabilitum crystallina weight for the second time, filters; Merging filtrate, filtrating concentrates, and obtains in the time of 60 ℃ relative density and be 1.40 extractum;
(3) merge above-mentioned two kinds of extractum, vacuum drying is pulverized the back mixing;
(4) get Borneolum Syntheticum 90g, Indigo Naturalis 40g, Margarita 8g, Calculus Bovis 7g, calcining calamitas urinae hominis 15g grind into powder adds the extract of Radix Glycyrrhizae that (3) step obtains, Mirabilitum crystallina, Rhizoma Coptidis, Radix Sophorae Tonkinensis again, and mixing sieves;
(5) vaseline of 200g and the lanoline of 15g are heated to 80 ℃ of fusions, are stirred to room temperature, stir, obtain the blank substrate of emulsifiable paste;
In the homomixture that sieves of all medicines that (6) step (4) obtained, add in the barren ointment base, mixing divides to be filled in the bag then.Every ointment 10g.
Method for using: after each affected part cleaning, emulsifiable paste evenly is applied to the affected part, every day 1 time, a week is a course of treatment.
The treatment situation: choose 200 routine experimenters, wherein male 105 examples, women 95 examples, at 1 years old-70 years old age, the course of disease is within two weeks.In observing case, according to curative effect determinate standard (with embodiment 1), curative effect such as following table 1 and table 2.
Embodiment 3
Borneolum Syntheticum 100g, Fructus Cnidii 70g, Radix Glycyrrhizae 90g, Indigo Naturalis 50g, Radix Sophorae Tonkinensis 80g, Rhizoma Coptidis 40g, Margarita 10g, Calculus Bovis 10g, calcining calamitas urinae hominis 20g, Mirabilitum crystallina 40g.
Method for preparing: the Radix Sophorae Tonkinensis and the Rhizoma Coptidis of said weight portion got in (1), is ground into powder, the alcohol reflux with 70% 2 times, each 2.5 hours; Add for the first time 8 times of amounts of alcohol, add 6 times of amounts of alcohol for the second time, filter; Merge extractive liquid,, filtrating concentrates, and obtains in the time of 60 ℃ relative density and be 1.50 extractum;
(2) get the Radix Glycyrrhizae and the Mirabilitum crystallina of said weight portion, decocte with water secondary, each 2.5 hours; Amount of water is 8 times of Radix Glycyrrhizaes and Mirabilitum crystallina weight for the first time; Amount of water is 6 times of Radix Glycyrrhizaes and Mirabilitum crystallina weight for the second time, filters merging filtrate; Filtrating concentrates, and obtains in the time of 60 ℃ relative density and be 1.50 extractum;
(3) merge above-mentioned two kinds of extractum, vacuum drying is pulverized the back mixing;
(4) get Borneolum Syntheticum 100g, Indigo Naturalis 50g, Margarita 10g, Calculus Bovis 10g, calcining calamitas urinae hominis 20g grind into powder adds the extract of Radix Glycyrrhizae that (3) step obtains, Mirabilitum crystallina, Rhizoma Coptidis, Radix Sophorae Tonkinensis again, and mixing sieves;
(5) vaseline of 250g and the lanoline of 20g are heated to 80 ℃ of fusions, are stirred to room temperature, stir, obtain the blank substrate of emulsifiable paste;
In the homomixture that sieves of all medicines that (6) step (4) obtained, add in the barren ointment base, mixing divides to be filled in the bag then.Every ointment 10g.
Method for using: after each affected part cleaning, emulsifiable paste evenly is applied to the affected part, every day 1 time, a week is a course of treatment.
The treatment situation: choose 200 routine testing crews, wherein male 96 examples, women 104 examples, at 1 years old-70 years old age, the course of disease is within two weeks.In observing case, according to curative effect determinate standard (with embodiment 1), curative effect such as following table 1 and table 2.
What matched group was chosen is the compound recipe Dexamethasone Acetate Cream, is called PIYANPING again, is mainly used in allergic dermatitis and autoimmune inflammation property disease.Like local pruritus, neurodermatitis, basic dermatitis, seborrheic dermatitis, chronic eczema etc.
The clinical effectiveness statistics is seen table 1 among the foregoing description 1-3.
Treatment group and matched group curative effect are relatively after 1 week of table 1 treatment
| Group | The test number | The recovery from illness number | The produce effects number | Effective number | Invalid number | Total effective rate |
| Embodiment 1 | 200 | 95 | 58 | 15 | 32 | 84.0％ |
| Embodiment 2 | 200 | 98 | 61 | 14 | 27 | 86.5％ |
| Embodiment 3 | 200 | 94 | 60 | 12 | 34 | 83.0％ |
| Matched group | 200 | 82 | 45 | 23 | 50 | 75.0％ |
Treatment group and matched group curative effect are relatively after two weeks of table 2 treatment
| Group | The test number | The recovery from illness number | The produce effects number | Effective number | Invalid number | Total effective rate |
| Embodiment 1 | 200 | 108 | 64 | 10 | 12 | 91.0％ |
| Embodiment 2 | 200 | 112 | 67 | 12 | 9 | 95.5％ |
| Embodiment 3 | 200 | 109 | 63 | 7 | 21 | 89.5％ |
| Matched group | 200 | 103 | 50 | 17 | 30 | 85.0％ |
Curative effect is relatively seen table 1, table 2 before and after four groups of patient treatments.By shown in the table 1; After treating for 1 week; Treatment group 1-3 and matched group total effective rate are respectively 84.0%, 86.5%, 83.0%, 75.0%, and by shown in the table 2, the total effective rate of 2 week of treatment back treatment group 1-3 and matched group is respectively 91.0%, 95.5%, 89.5%, 85.0%.Treatment group curative effect obviously is superior to matched group.And can find to adopt the therapeutic effect of medicine of prescription of treatment group 2 all better according to contrast than treatment group 1 and 3.
The present invention is extensively collecting on secret recipe, the folk prescription basis, and the pure Chinese medicine of screening 10 flavors is suited the remedy to the case in the long-term practice application, and specificity is strong, and effect is unique, and is not only very remarkable to the eczema curative effect, and relevant refractory skin is all had effect preferably.And easy to use, it is quick to take effect.This Department of Pharmacy's external used medicine only need be embrocated the affected part, can take effect immediately, and short treating period, good effect, safe and reliable, have no side effect.Be the natural Chinese medicines preparation, do not contain hormone, no dependence, safe and reliable.Medicine of the present invention had both had powerful treatment effect fast, simultaneously maintenance action was preferably arranged again, and once healing, was difficult to recurrence.Clinical practice proves that behind this preparation of external, the property of medicine can directly act on pathological tissues, and curative effect is obvious.Therefore be with a wide range of applications.
Claims (2)
1. medicine for external application of treating eczema; Be ointment dosage form; It is characterized in that: by the extract of Radix Sophorae Tonkinensis, Rhizoma Coptidis, Radix Glycyrrhizae and Mirabilitum crystallina; Borneolum Syntheticum, Fructus Cnidii, Indigo Naturalis, Margarita, calamitas urinae hominis and artificial Calculus Bovis's abrasive flour is with the blank substrate mixing preparation formation of vaseline and lanoline emulsifiable paste; In parts by weight, raw material is made up of following component: 60～110 parts of Borneolum Syntheticums, 20～80 parts of Fructus Cnidiis, 50～100 parts in Radix Glycyrrhizae; 30～50 parts of Indigo Naturaliss, Radix Sophorae Tonkinensis 40-80 part, 15～40 parts of Rhizoma Coptidis; 5～10 parts of Margaritas, 5～10 parts of Calculus Boviss, 10～20 parts of calcining calamitas urinae hominises; 20～40 parts of Mirabilitum crystallinas, 150～250 parts in vaseline, 10～20 parts of lanolines;
The extract of said Radix Sophorae Tonkinensis and Rhizoma Coptidis is an ethanol extraction; The extract of said Radix Glycyrrhizae and Mirabilitum crystallina is a water extract;
Ethanol extraction is by composition of raw materials, gets Radix Sophorae Tonkinensis and Rhizoma Coptidis powder is broken into powder, uses the alcohol reflux gained; Described alcohol reflux is that to use weight concentration be 50%～70% alcohol reflux 2 times, extracts 1～3 hour at every turn, and amount of alcohol added is Radix Sophorae Tonkinensis and Rhizoma Coptidis powder 6～8 times for the first time; For the second time amount of alcohol added is Radix Sophorae Tonkinensis and Rhizoma Coptidis powder 4～6 times; Filter, merge extracted twice liquid, filtrating concentrates, and obtains in the time of 60 ℃ relative density and be 1.20～1.50 extractum;
Water extract is by composition of raw materials, and extracting liquorice and Mirabilitum crystallina are ground into powder, uses the water boiling and extraction gained; Said water boiling and extraction is meant the decocte with water secondary; The each decoction 1～3 hour, amount of water is Radix Glycyrrhizae and Mirabilitum crystallina weight 6～8 times for the first time, the second time, amount of water was Radix Glycyrrhizae and Mirabilitum crystallina weight 4～6 times; Filter; Merge to decoct filtrating, filtrating concentrates, and obtains in the time of 60 ℃ relative density and be 1.20～1.50 extractum.
2. the described a kind of method for preparing that is used to treat the medicine for external application of eczema of claim 1 is characterized in that, may further comprise the steps:
(1) presses composition of raw materials, get Radix Sophorae Tonkinensis and Rhizoma Coptidis powder is broken into powder, use alcohol reflux;
(2) press composition of raw materials, extracting liquorice and Mirabilitum crystallina are ground into powder, use water boiling and extraction;
(3) extracting solution of combining step (1) step (2), vacuum drying is pulverized the back mixing;
(4) with Borneolum Syntheticum 60～110 weight portions, Fructus Cnidii 20～80 weight portions, Indigo Naturalis 30～50 weight portions; Margarita 5～10 weight portions; Calculus Bovis 5～10 weight portions, calcining calamitas urinae hominis 10～20 weight portions, grind into powder; Add the extract of Radix Glycyrrhizae that (3) step obtains, Mirabilitum crystallina, Rhizoma Coptidis, Radix Sophorae Tonkinensis again, mixing sieves;
(5) vaseline and 10～20 weight portion lanolines with 150～250 weight portions are heated to 80 ℃ of fusions, are stirred to room temperature, stir, and obtain the blank substrate of emulsifiable paste;
In the homomixture that sieves of all medicines that (6) step (4) obtained, add in the barren ointment base, divide then to be filled in the bag; Every bag of 10g.
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| CN201010221526A CN101904911B (en) | 2010-07-08 | 2010-07-08 | External application drug for treating eczema and preparation method thereof |
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| CN201010221526A CN101904911B (en) | 2010-07-08 | 2010-07-08 | External application drug for treating eczema and preparation method thereof |
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| US20140243354A1 (en) * | 2013-02-22 | 2014-08-28 | Galderma Research & Development Snc | Combinations of indigo naturalis and berberine and uses thereof |
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| CN101485719A (en) * | 2008-01-16 | 2009-07-22 | 北京天科仁祥医药科技有限公司 | Chinese medicinal composition for preventing and treating skin disease and preparation method thereof |
| CN101607014B (en) * | 2008-06-18 | 2011-11-23 | 朱春燕 | Ointment for promoting tissue regeneration and restraining sore and preparation method thereof |
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| Title |
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| 余有庆等.蛇床子.《中药临床备要》.甘肃文化出版社,2008,558-559. * |
| 石磊等.油质性基质软膏制备经验点滴.《中国药业》.2000,第9卷(第5期),26. * |
| 马素英等.司帕沙星锌软膏剂的制备和临床应用.《现代医药卫生》.2007,第23卷(第11期),1596-1598. * |
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