CN101897746A - Composite used for relieving alcoholic intoxication and protecting liver and preparation method and application thereof - Google Patents
Composite used for relieving alcoholic intoxication and protecting liver and preparation method and application thereof Download PDFInfo
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- CN101897746A CN101897746A CN2009100522759A CN200910052275A CN101897746A CN 101897746 A CN101897746 A CN 101897746A CN 2009100522759 A CN2009100522759 A CN 2009100522759A CN 200910052275 A CN200910052275 A CN 200910052275A CN 101897746 A CN101897746 A CN 101897746A
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- radix notoginseng
- cactus
- fructus rosae
- rosae normalis
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- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- 210000004185 liver Anatomy 0.000 title abstract description 24
- 208000005584 Alcoholic Intoxication Diseases 0.000 title abstract description 9
- 239000002131 composite material Substances 0.000 title abstract 3
- 241000219357 Cactaceae Species 0.000 claims abstract description 38
- 244000131316 Panax pseudoginseng Species 0.000 claims abstract description 5
- 235000003181 Panax pseudoginseng Nutrition 0.000 claims abstract description 5
- 241000180649 Panax notoginseng Species 0.000 claims description 57
- 235000003143 Panax notoginseng Nutrition 0.000 claims description 57
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 39
- 239000000203 mixture Substances 0.000 claims description 27
- 239000000843 powder Substances 0.000 claims description 26
- 239000003814 drug Substances 0.000 claims description 18
- 230000002075 anti-alcohol Effects 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 12
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- 239000002253 acid Substances 0.000 claims description 2
- 208000022309 Alcoholic Liver disease Diseases 0.000 abstract 1
- 240000002547 Rosa roxburghii Species 0.000 abstract 1
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 51
- 229960003180 glutathione Drugs 0.000 description 32
- 230000000694 effects Effects 0.000 description 19
- 102000005720 Glutathione transferase Human genes 0.000 description 18
- 108010070675 Glutathione transferase Proteins 0.000 description 18
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- 230000008520 organization Effects 0.000 description 12
- 102000004190 Enzymes Human genes 0.000 description 10
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- 241000699666 Mus <mouse, genus> Species 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
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- 229930182555 Penicillin Natural products 0.000 description 2
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- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 2
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a composite used for relieving alcoholic intoxication and protecting a liver and a preparation method and application thereof. The composite of the invention comprises radix pseudo-ginseng and rosa roxbughii tratt cacti, and can effectively eliminate the attack to large biological molecules caused by free radicals generated due to overdrinking, effectively relieve alcoholic intoxication and prevent alcoholic liver damage, thereby realizing the efficacies of relieving the alcoholic intoxication and protecting the liver, and embodying better component synergism.
Description
Technical field
The invention belongs to natural plants goods field, specifically, relate to a kind of compositions, its preparation method and application that is used for Antialcoholic liver-protecting.
Background technology
Long-term excessive consumption of alcohol is very unfavorable to health, not only can damage internal organs such as liver, stomach, spleen, also may cause diseases such as alcoholic hepatitis and liver cirrhosis.Therefore, seeking effective ethanol antidote has been the focus that people pay close attention to, and wine product is separated in development fast and effectively also becomes a current important problem.
But, therefore, the exploitation of Antialcoholic liver-protecting goods still concentrated on from natural plant component seek on the active component level because the mechanism of relieving the effect of alcohol it be unclear that.
Radix Notoginseng is the root of Araliaceae herbaceos perennial Radix Notoginseng, claims Radix Notoginseng, Panax pseudoginseng, mountain lacquer etc. again.Pharmacological research to Radix Notoginseng finds that Radix Notoginseng has the function that the liver protecting is avoided (as ethanol and carbon tetrachloride) injury of chemical.In the zoopery of rat, Radix Notoginseng can prevent microangiopathies in hepatic fibrosis that the liver ischemia causes and the liver, and in the effective anti-inflammatory reaction of symptom initial stage.
Fructus Rosae Normalis Cactus grows in the area, America, and stem shape such as pears cover with thick thorn, and delicate fragrance is edible after the tender stem deburring.That the Fructus Rosae Normalis Cactus extract has is anticancer, the function of anti-inflammatory, free radical resisting infringement be it is found that successively.Simultaneously, people recognize gradually that also the Fructus Rosae Normalis Cactus extract can effectively accelerate the accretion rate of ethanol, reduce alcoholic liver injury.
Existing studies show that, multiple material with said function is united when using, and its effect may become mutual antagonism, for example, have antagonism between some beneficial trace elements, when several elements coexisted simultaneously in vivo, their effect just may change; Penicillin and chloromycetin are fast effect bacteriostatic, but after share, can weaken the bactericidal action of penicillins.
Therefore, studies show that Radix Notoginseng and America Fructus Rosae Normalis Cactus all can be used for Antialcoholic liver-protecting, also do not see the report of use in conjunction Radix Notoginseng and America Fructus Rosae Normalis Cactus at present though have now.But because the mechanism of relieving the effect of alcohol it be unclear that, therefore, when uniting when using Radix Notoginseng and America Fructus Rosae Normalis Cactus, to the effect of separately Antialcoholic liver-protecting, antagonism can take place still bring into play cooperative effect and can't prejudge.
Summary of the invention
The inventor finds to unite and uses Radix Notoginseng and America Fructus Rosae Normalis Cactus to have good synergism in the process of seeking the ethanol antidote, and the accretion rate of accelerating ethanol, the effect of reduction alcoholic liver injury obviously are better than the function of one-component.
Therefore, the objective of the invention is to, a kind of compositions that is used for Antialcoholic liver-protecting is provided, with accretion rate, the reduction alcoholic liver injury that is used to accelerate ethanol.
Another object of the present invention is, the described preparation of compositions method that is used for Antialcoholic liver-protecting is provided.
A further object of the invention is, the application of the compositions of described Antialcoholic liver-protecting is provided.
The compositions that is used for Antialcoholic liver-protecting of the present invention is made up of Radix Notoginseng and Fructus Rosae Normalis Cactus.
According to the present invention, described Radix Notoginseng is adopted the extract of Radix Notoginseng powder, and described America Fructus Rosae Normalis Cactus adopts the extract of Fructus Rosae Normalis Cactus.
According to a preferred embodiment of the present invention, in the described compositions, the mass ratio of Radix Notoginseng powder extract and Fructus Rosae Normalis Cactus extract is 1: 1.
The preparation of compositions method that is used for Antialcoholic liver-protecting of the present invention may further comprise the steps:
1) extract of preparation Radix Notoginseng powder;
2) extract of preparation Fructus Rosae Normalis Cactus;
3) the Radix Notoginseng powder extract is mixed with Fructus Rosae Normalis extract.
According to a preferred embodiment of the present invention, the extract of described Radix Notoginseng powder obtains by following steps:
Get pseudo-ginseng, use alcohol reflux, collect backflow and dry.
According to another embodiment of the invention, the extract of described Fructus Rosae Normalis obtains by following steps:
The washing Fructus Rosae Normalis Cactus, the section back homogenizes with weak acid, again centrifuging and taking supernatant and dry.
The compositions of Radix Notoginseng of the present invention and Fructus Rosae Normalis Cactus can be used for preparing the medicine of Antialcoholic liver-protecting.
Use compositions provided by the invention, can accelerate accretion rate, the reduction alcoholic liver injury of ethanol effectively.Act on separately than Fructus Rosae Normalis Cactus extract and Radix Notoginseng powder, Fructus Rosae Normalis Cactus and Radix Notoginseng acted on mice with 1: 1 after the mixed, can alleviate the inhibitory action of ethanol for glutathion, glutathione S-transferase vigor, glutathione peroxidase activity by significance; Simultaneously, all right significance improves level, glutathion peroxidase level (GSH-PX) and the glutathion-S transferring enzyme level (GST) of reductive glutathione in the body, and then eliminate the attack of the radical pair biomacromolecule that excessive consumption of alcohol produces effectively, alcoholic intoxication effectively, the prevention alcoholic liver injury, better realize the effect of Antialcoholic liver-protecting, embody component coordinative role preferably.
The specific embodiment
Below in conjunction with specific embodiment, the invention will be further described.Should be understood that following examples only are used to the present invention is described but not are used to limit scope of the present invention.
In following embodiment of the present invention, the Radix Notoginseng of use is sold the base directly to households available from the Yunnan Radix Notoginseng, and Fructus Rosae Normalis Cactus obtains from the California, USA locality.
In following embodiment of the present invention, glutathione level in the mouse liver even slurry, the glutathion (GSH) (removing albumen) that adopts Nanjing to build up is measured kit measurement.
Glutathion peroxidase in the mouse liver even slurry (GSH-PX) level, glutathion peroxidase (GSH-PX) testing cassete that adopts Nanjing to build up is measured.
Glutathion in the mouse liver even slurry-S transferring enzyme level, the glutathion-S transferring enzyme that adopts Nanjing to build up is measured kit measurement.
Embodiment 1, the Radix Notoginseng powder extract preparation
Get pseudo-ginseng and pulverize in right amount, accurately weighing adds the alcohol reflux 2 times of 10 times of amounts 60%, and each 1.5h merges medicinal liquid, concentrates, dry dry powder.
Embodiment 2, the Fructus Rosae Normalis Cactus extract preparation
Get Fructus Rosae Normalis Cactus, be cut into lamellar after the washing, centrifuging and taking supernatant after reuse Tris hydrochloric acid homogenizes, drying for standby.
Embodiment 3, preparation of compositions
Get the Fructus Rosae Normalis Cactus extract that obtains by the method for embodiment 1 respectively and,, obtain the compositions of Fructus Rosae Normalis Cactus extract and Radix Notoginseng powder extract with 1: 1 mixed of mass ratio by the Radix Notoginseng powder extract that the method for embodiment 2 obtains.
Embodiment 4, zoopery
Protection effect for the mixture that detects Fructus Rosae Normalis Cactus extract and Radix Notoginseng powder extract; respectively glutathione level (GSH), glutathione peroxidase activity level (GSH-PX), glutathion-S transferring enzyme activity level (GST) through the mice of this mixture protection are detected; and with normal group as blank; drink group as negative control with no medicament protection; with Fructus Rosae Normalis Cactus extract group and Radix Notoginseng powder extract group as a comparison, specific as follows:
Test mice is divided into 5 groups at random, 10 every group, carries out following processing every day:
First group (normal group): when 0h, irritate stomach, when 1h, irritate stomach with normal saline (10ml/kg) again with normal saline (10ml/kg);
Second group (no medicament protection drink group): when 0h, irritate stomach, when 1h, irritate stomaches with 55 degree strong, colourless liquor distilled from sorghum (10ml/kg) again with normal saline (10ml/kg);
The 3rd group (Radix et Caulis Opuntiae Dillenii extract's group): when 0h, irritate stomach, when 1h, irritate stomach with 55 degree strong, colourless liquor distilled from sorghum (10ml/kg) again with the Fructus Rosae Normalis Cactus extract (0.5g/kg) that the method for pressing embodiment 1 obtains;
The 4th group (Radix Notoginseng powder extract group): when 0h, irritate stomach, when 1h, irritate stomach with 55 degree strong, colourless liquor distilled from sorghum (10ml/kg) again with the Radix Notoginseng powder extract (0.5g/kg) that the method for pressing embodiment 2 obtains;
The 5th group (Radix et Caulis Opuntiae Dillenii+panax mixed group): when 0h, irritate stomach, when 1h, irritate stomaches with 55 degree strong, colourless liquor distilled from sorghum (10ml/kg) again with the Fructus Rosae Normalis Cactus extract of the method preparation of pressing embodiment 3 and the compositions (1g/kg) of Radix Notoginseng powder extract.
Experimental period is 10 days, all mices are irritated before the stomach operation all fasting every day and prohibit water 3h, after (the 10th day) irritates stomach for the last time, fasting is put to death mice after prohibiting water 16h, gets hepatic tissue, detects GSH (glutathion), GST (glutathion-S transferring enzyme), GSH-PX (glutathion peroxidase) in the hepatic tissue, testing result is shown in table 1-3, wherein, the GSH testing result is as shown in table 1, the GSH relative amount with no medicament protection drink the group be 100%; The glutathione peroxidase activity testing result is as shown in table 2, the relative vigor of GSH-PX with no medicament protection drink the group be 100%; Glutathion-S transferring enzyme vigor testing result is as shown in table 3, the relative vigor of GST with no medicament protection drink the group be 100%.
GSH content in each experimental group liver organization of table 1
Liver organization GSH content (mg/gprot) | The GSH relative amount | |
Normal group | 6.93 | -- |
The no medicament protection group of drinking | 4.77 | 100% |
The Radix et Caulis Opuntiae Dillenii extract | 4.08 | 85.5% |
The Radix Notoginseng powder group | 7.04 | 147.7% |
Radix et Caulis Opuntiae Dillenii+panax mixed group | 7.71 | 161.8% |
The result of table 1 shows, compares normal group, because the inhibitory action that excessive alcohol produces, no medicament protection is drunk, and GSH content has obvious decline in the liver organization of organizing; Compare the no medicament protection group of drinking, " Radix et Caulis Opuntiae Dillenii extract " group fails effectively to improve GSH content, and the GSH content of " Radix Notoginseng powder " group has improved 47.7%, and the GSH content of " Radix et Caulis Opuntiae Dillenii+Radix Notoginseng " combined group has improved 61.8%.
According to the result of table 1, " Radix et Caulis Opuntiae Dillenii+Radix Notoginseng " combined group has alleviated the inhibitory action of ethanol for glutathione content effectively, obviously is better than two kinds of components aspect the liver organization GSH expression and acts on separately improving, and embodies significant synergy.And increasing of GSH expression can be removed intravital ethanol timely and effectively, alleviates alcoholism situation, the liver protecting, and therefore, the compositions of " Radix et Caulis Opuntiae Dillenii+Radix Notoginseng " can be used to remove intravital ethanol, alleviates alcoholism situation, the liver protecting.
GSH-PX vigor in each experimental group liver organization of table 2
GSH-PX vigor (U/mgprot) in the liver organization | The relative vigor of GSH-PX | |
Normal group | 6248.8 | -- |
The no medicament protection group of drinking | 5466.7 | 100% |
The Radix et Caulis Opuntiae Dillenii extract | 6186.8 | 113.2% |
The Radix Notoginseng powder group | 6254.6 | 114.4% |
Radix et Caulis Opuntiae Dillenii+panax mixed group | 6665.8 | 121.9% |
The result of table 2 shows, compares normal group, because the inhibitory action that excessive alcohol produces, no medicament protection is drunk, and the GSH-PX vigor has obvious decline in the liver organization of organizing; Compare the no medicament protection group of drinking, the GSH-PX vigor of " Radix et Caulis Opuntiae Dillenii extract " group has improved 13.2%, and the GSH-PX vigor of " Radix Notoginseng powder " group has improved 14.4%, and the GSH-PX vigor of " Radix et Caulis Opuntiae Dillenii+Radix Notoginseng " combined group has improved 21.9%.
Result according to table 2, " Radix et Caulis Opuntiae Dillenii+Radix Notoginseng " combined group has effectively alleviated the inhibitory action of ethanol for glutathione peroxidase activity, obviously be better than two kinds of components aspect the liver organization GSH-PX vigor and act on separately improving, embody significant synergy.And GSH-PX is the enzyme that the extensive a kind of important catalyzing hydrogen peroxide that exists decomposes in the body.Hepatocyte is exactly to remove free radical and prevent that peroxidation from protecting hepatocyte by the activity that increases glutathion peroxidase.Activity of glutathione peroxidase increase the attack that can eliminate the radical pair biomacromolecule, therefore, the compositions of " Radix et Caulis Opuntiae Dillenii+Radix Notoginseng " can be used in alcoholic intoxication, the prevention alcoholic liver injury.
GST vigor in each experimental group liver organization of table 3
GST vigor (U/mgprot) in the liver organization | The relative vigor of GST | |
Normal group | 188.67 | -- |
The no medicament protection group of drinking | 171.77 | 100% |
The Radix et Caulis Opuntiae Dillenii extract | 189.03 | 110.0% |
The Radix Notoginseng powder group | 185.47 | 108.0% |
Radix et Caulis Opuntiae Dillenii+panax mixed group | 193.17 | 112.5% |
The result of table 3 shows, compares normal group, because the inhibitory action that excessive alcohol produces, no medicament protection is drunk, and the GST vigor has obvious decline in the liver organization of organizing; Compare the no medicament protection group of drinking, the GST vigor of " Radix et Caulis Opuntiae Dillenii extract " group has improved 10%, and the GST vigor of " Radix Notoginseng powder " group has improved 8%, and the GST vigor of " Radix et Caulis Opuntiae Dillenii+Radix Notoginseng " combined group has improved 12.5%.
3 results according to table, " Radix et Caulis Opuntiae Dillenii+Radix Notoginseng " combined group has effectively alleviated the inhibitory action of ethanol for the glutathione S-transferase vigor, be better than two kinds of components aspect liver organization glutathione S-transferase (GST) vigor and act on separately improving, embody certain synergy.And glutathione S-transferase is the key enzyme of glutathion association reaction, and the initial step of catalysis glutathion association reaction mainly is present in the cytosol, is one of important enzyme that stress alcoholic liver injury in the body.Activity of glutathione peroxidase increase the attack that can eliminate the radical pair biomacromolecule, alcoholic intoxication effectively, the prevention alcoholic liver injury, therefore, the compositions of " Radix et Caulis Opuntiae Dillenii+Radix Notoginseng " can be used in alcoholic intoxication, the prevention alcoholic liver injury.
In sum, act on separately than Fructus Rosae Normalis Cactus extract and Radix Notoginseng powder, Radix Notoginseng and Fructus Rosae Normalis Cactus act on mice after with 1: 1 mixed, can alleviate the inhibitory action of ethanol for glutathion, glutathione S-transferase vigor, glutathione peroxidase activity by significance; Simultaneously, all right significance improves level, glutathion peroxidase level (GSH-PX) and the glutathion-S transferring enzyme level (GST) of reductive glutathione in the body, and then eliminate the attack of the radical pair biomacromolecule that excessive consumption of alcohol produces effectively, alcoholic intoxication effectively, the prevention alcoholic liver injury, thereby realize the effect of Antialcoholic liver-protecting, embody component coordinative role preferably.
Therefore, the compositions of Radix Notoginseng of the present invention and Fructus Rosae Normalis Cactus can be used to prepare the medicine of Antialcoholic liver-protecting, except Fructus Rosae Normalis Cactus and these two kinds of components of Radix Notoginseng, can also add acceptable auxiliary on one or more pharmacology, this is conspicuous for a person skilled in the art.
Claims (10)
1. the compositions of an Antialcoholic liver-protecting, it is characterized in that: described compositions is made up of Radix Notoginseng and Fructus Rosae Normalis Cactus.
2. compositions as claimed in claim 1 is characterized in that: described Radix Notoginseng is adopted the extract of Radix Notoginseng.
3. compositions as claimed in claim 1 is characterized in that: described Fructus Rosae Normalis Cactus adopts the extract of Fructus Rosae Normalis Cactus.
4. compositions as claimed in claim 1 is characterized in that: the mass ratio of described compositions Radix Notoginseng and Fructus Rosae Normalis Cactus is 1: 1.
5. each described preparation of compositions method in the claim 1~4 is characterized in that may further comprise the steps:
1) extract of preparation Radix Notoginseng powder;
2) extract of preparation Fructus Rosae Normalis Cactus;
3) the Radix Notoginseng powder extract is mixed with Fructus Rosae Normalis extract.
6. method as claimed in claim 5 is characterized in that: the extract of described Radix Notoginseng powder obtains by the following method:
Get pseudo-ginseng, use alcohol reflux, collect backflow and dry.
7. application as claimed in claim 5 is characterized in that: the extract of described Fructus Rosae Normalis Cactus obtains by the following method:
The washing Fructus Rosae Normalis Cactus, the section back homogenizes with weak acid, again centrifuging and taking supernatant and dry.
8. application as claimed in claim 5 is characterized in that: the mass ratio of the extract of described Radix Notoginseng powder extract and Fructus Rosae Normalis Cactus is 1: 1.
9. the application of each described compositions in the claim 1~4 is characterized in that: the medicine that is used to prepare Antialcoholic liver-protecting.
10. application as claimed in claim 9 is characterized in that described medicine also comprises acceptable auxiliary on one or more pharmacology.
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CN1397227A (en) * | 2001-07-16 | 2003-02-19 | 赵江梅 | Health-care beverage containing components of ginseng and chrysanthenum flower |
CN101011525A (en) * | 2007-02-02 | 2007-08-08 | 昆明市强制戒毒所 | Antihyperglycemic hepatoprotective agent |
CN101033445A (en) * | 2006-12-29 | 2007-09-12 | 天津津酒集团有限公司 | Wine capable of protecting liver and preserving one's health and preparing method thereof |
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2009
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Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1397227A (en) * | 2001-07-16 | 2003-02-19 | 赵江梅 | Health-care beverage containing components of ginseng and chrysanthenum flower |
CN101033445A (en) * | 2006-12-29 | 2007-09-12 | 天津津酒集团有限公司 | Wine capable of protecting liver and preserving one's health and preparing method thereof |
CN101011525A (en) * | 2007-02-02 | 2007-08-08 | 昆明市强制戒毒所 | Antihyperglycemic hepatoprotective agent |
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Address after: 200031 Yueyang Road, Shanghai, No. 319, No. Patentee after: Shanghai Institute of nutrition and health, Chinese Academy of Sciences Address before: 200031 No. 320, Yueyang Road, Shanghai, Xuhui District Patentee before: SHANGHAI INSTITUTES FOR BIOLOGICAL SCIENCES, CHINESE ACADEMY OF SCIENCES |
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