CN101896164B

CN101896164B - Process for producing biological ingesta

Info

Publication number: CN101896164B
Application number: CN200880113038.2A
Authority: CN
Inventors: 榎村真一
Original assignee: M Technique Co Ltd
Current assignee: M Technique Co Ltd
Priority date: 2007-09-10
Filing date: 2008-09-10
Publication date: 2014-10-22
Anticipated expiration: 2028-09-10
Also published as: CN101896164A; JP2012062316A; EP2196194B1; US8927020B2; US20100330153A1; WO2009034980A1; JP4849647B2; JP5424427B2; JPWO2009034980A1; EP2196194A4; EP2196194A1

Abstract

A process in which a biological ingesta of desired particle diameter can be produced with the use of energy less than in conventional processes. A fluid to be treated of disperse phase containing a pharmacologically active substance and a fluid to be treated of continuous phase consisting of at least a dispersion solvent while maintaining the mutually independent states thereof are mixed together through mutually independent channels corresponding to the individual phases in a thin film fluid provided between treating planes laid in opposed relationship so as to be capable of approaching to or separating from each other, at least one of the treating planes being rotatable with reference to the other. Accordingly, the component contained in the fluid to be treated of disperse phase is formed into microparticles of desired diameter.

Description

The manufacture method of biological uptake thing

Technical field

Uniform microgranule and can be safely mass-produced, biological uptake thing (raw body feeding is got thing) the present invention relates to easily to manufacture, can be made and a kind of microemulsion particle of microcapsule, the manufacture method of liposome formed.

Background technology

Patent documentation 1: JP 2003-119120 communique

Patent documentation 2: Unexamined Patent 4-46115 communique

Patent documentation 3: Unexamined Patent 11-47580 communique

Non-patent literature 1: Qiu Jiyi becomes, and Tsuji well smokes supervision, " the new expansion of liposome application-towards the exploitation of artificial cell ", the NTS of Co., Ltd., in June, 2005

Now, microcapsule, except the medicament capsule of pharmaceuticals etc., has also attempted the various application at transdermal formulation, per os preparation, immunological adjuvant, artificial red blood cell, artificial platelet, cosmetics, hair restoring and curing agent, antibacterial etc.In addition, the research using as the reacting field (bioreactor) of artificial cell film, medicine transporter ( removes body), gene delivery system, nanometer scale etc. is just prevailing, seek few using carrying capacity of environment, preserve good security and can easily manufacture the manufacture method of mass producible as the microcapsule of the particle diameter of object.

As a kind of liposome of this microcapsule, have can in interior water, keep water-soluble substances, at inner liposoluble substances, the i.e. so-called capsule structure of keeping of two molecular films.As the manufacture method of liposome, till now, report has a lot of methods such as Bangham method, organic solvent injection method, reverse phase evaporation.But any method is all a large amount of methods that use environment and the harmful organic solvent of human body, does not use a large amount of organic solvents, the method for manufacturing the liposome that the maintenance efficiency of water-soluble substances is high does not almost have.

Now, as industrial production method, motion has the method for manufacturing liposome, microemulsion particle by mechanical shearing force.As the machinery using, there are preparation dispersion machine and accurate dispersion machine, how in preparation dispersion machine, to use high-speed rotary dispersion machine transition, in accurate dispersion machine, use high pressure homogenisers.These methods, although there is the advantage that does not use organic solvent such, are not suitable for the macromolecule a little less than shearing force, have the large such problem of energy charge.

In addition, the method (patent documentation 1) of manufacturing liposome with supercritical carbon dioxide replacement organic solvent is disclosed.Establish in the method and can set various creating conditions, compared with the manufacture method of liposome in the past, can manufacture with comparalive ease the liposome having as particle diameter, the structure etc. of object.Even if the liposome of the picked-up of the target site in body is a small amount of, improve if enclose the interior bag rate of material, can obtain desirable effect, therefore, expected as the manufacture method of DDS preparation.But, in the method, exist while processing and must at the temperature of 20～200 DEG C, apply 50～500kg/m ³pressure, must use in advance ready-mixed operation that homogenizer etc. mixes etc., cost running expense, elongated, the other operation sequence of operation sequence complicated, with dangerous, because energy charge is not suitable for greatly the such problem of commercial production.

Same as a kind of microemulsion particle of microcapsule, in the various field such as cosmetics, pharmaceuticals, pesticide, water paint, wax, food, used.As the method for manufacturing such microemulsion particle, in the aqueous solution of the known non-ionic surface active agent at high HLB, add the method for hydrocarbon ils, raising temperature, in lipophile nonionic surfactant and specific ionic surfactant or lipophile nonionic surfactant and ionic surfactant's combination, add electrolytical method, the fluid mixture that contains oil content is applied to strong shearing force, by the method for emulsion particle miniaturization (patent documentation 2).These methods have the variety of issue of equilibrium temperature narrow range etc.For example, carried out following report.In the situation that using high-pressure emulsification device to carry out emulsifying, because if substrate (base) temperature rise while processing of highland setting pressure, therefore often for example, to the stability of emulsion exert an influence (patent documentation 3).In addition, although the method that also useful ultrasonic irradiation of motion etc. is processed,, be difficult to large-scale manufacture with ultrasound wave.

Biological uptake thing, the liposome and the microemulsion particle that for example use as pharmaceuticals, food, cosmetics etc., its in character, manufacture and quality management business must give new concern.Meanwhile, also require even, the interior bag rate of ageing stability excellence, particle diameter of particle good., can say the establishment of the preparation technology that requirement can easily manufacture.

In addition, as liposome, the microemulsion particle of biological uptake thing, in a lot of situations, preferably particle diameter performance less, function in biology is also better, in addition, from the viewpoint of stabilisation, also require corpusculed more.But, make particle diameter little, must cast larger energy to handled thing, have to tackle in such problems such as the risings of long-term, the surfactant concentration in processing time.

The present invention, point in view of the above-mentioned problems, to solve them as problem, provides with method in the past and is in a ratio of low-yield the method obtaining as the biological uptake thing of the particle diameter of object.That is, provide that energy efficiency is high, the manufacture method of safety, biological uptake thing that carrying capacity of environment is few, and, provide and can obtain the uniform biological uptake thing of particle diameter, method that productivity ratio is high.

Summary of the invention

In order to solve above-mentioned problem, the invention that the application's claim 1 relates to, by a kind of manufacture method of biological uptake thing is provided, solve above-mentioned problem, described manufacture method is characterised in that, in the manufacture method of the microemulsion particle as biological uptake thing, by the processed liquid of the decentralized photo of the oil-phase component that contains fat-soluble pharmacological active substance, and at least comprise the processed liquid of continuous phase that water system is disperseed solvent, remaining respectively independently under state, by the independently path of the phase corresponding to separately, there is the processing face of the approached separation that subtend arranges, the processing that at least one party is rotated with respect to the opposing party is with mixing in the thin film fluid forming between face.

Be explained, above-mentioned organism, human body, from needless to say, also contains other organism.

In addition, the invention that the application's claim 2 relates to, by a kind of manufacture method of biological uptake thing is provided, solve above-mentioned problem, described manufacture method is characterised in that, in the manufacture method of the microemulsion particle as biological uptake thing, by the processed liquid of the decentralized photo of the water-phase component of the pharmacological active substance that contains containing water-soluble, and the processed liquid of the continuous phase at least being formed by oil system dispersion solvent, remaining respectively independently under state, by the independently path of the phase corresponding to separately, there is the processing face of the approached separation that subtend arranges, the processing that at least one party is rotated with respect to the opposing party is with mixing in the thin film fluid forming between face.

In addition, the invention that the application's claim 3 relates to, by a kind of manufacture method of biological uptake thing is provided, solve above-mentioned problem, described manufacture method is characterised in that, in the manufacture method of the liposome as biological uptake thing, the phospholipid that contains more than one at least either party of decentralized photo or continuous phase, above-mentioned decentralized photo contains pharmacological active substance, above-mentioned continuous phase at least comprises water system and disperses solvent, by the processed liquid of above-mentioned decentralized photo, and the processed liquid of above-mentioned continuous phase, remaining respectively independently under state, by the independently path of the phase corresponding to separately, there is the processing face of the approached separation that subtend arranges, the processing that at least one party is rotated with respect to the opposing party is with mixing in the thin film fluid forming between face.

In addition, the invention that the application's claim 4 relates to, by the manufacture method of the biological uptake thing described in any one of claims 1 to 3 is provided, solve above-mentioned problem, described manufacture method is characterised in that, above-mentioned manufacture method has the fluid pressure imparting mechanism of processed liquid being given to authorized pressure, the 1st handling part and can process and can approach the 2nd of separation with portion and process at least 2 processing use portions of use portion with respect to the 1st, and make the 1st above-mentioned processing portion and the 2nd process the rotary drive mechanism being relatively rotated with portion; In above-mentioned each processing use portion, mutually on the position of subtend, be provided with the 1st and process with face and the 2nd at least 2 processing faces processing with face; A part for the stream that above-mentioned each processing forms that the processed liquid of afore mentioned rules pressure flows through, sealed with face; Process with between faces above-mentioned two, by any one processed liquid that is above-mentioned decentralized photo at least, processed liquid of more than two kinds evenly mixes; The above-mentioned the 1st processes use portion and the 2nd processes in use portion, the at least the 2 processing has compression face with portion, and, at least a portion of this compression face is made up of with face the 2nd above-mentioned processing, this compression face is subject to above-mentioned fluid pressure imparting mechanism gives the pressure of processed liquid, is created in and makes the 2nd to process and process from the 1st the power moving up with the side of face separation with face; Process with between face by the processed liquid of afore mentioned rules pressure being passed into the 1st processing face and the 2nd that can approach separation and be relatively rotated, above-mentioned processed liquid one side forms the thin film fluid of specific thickness, and process with between faces by two on one side; And, there is the other importing road that is independent of the stream that the processed liquid of afore mentioned rules pressure flows through; The above-mentioned the 1st processes and at least in any, has the peristome that at least one communicates with above-mentioned importing road with face with face and the 2nd processing; At least one the processed liquid transporting from above-mentioned importing road is imported to above-mentioned two and process with between face, form thus above-mentioned thin film fluid; By the processed liquid of above-mentioned decentralized photo is mixed in above-mentioned thin film fluid with the processed liquid different from above-mentioned processed liquid, make composition contained in the processed liquid of above-mentioned decentralized photo form the fine particle with desirable particle diameter.

In addition, the invention that the application's claim 5 relates to, by the manufacture method of biological uptake thing claimed in claim 4 is provided, solve above-mentioned problem, described manufacture method is characterised in that, by the processed liquid of above-mentioned decentralized photo, import above-mentioned two from above-mentioned other importing road and process with between face.

In addition, the invention that the application's claim 6 relates to, by the manufacture method of the biological uptake thing described in any one of claims 1 to 3 is provided, solve above-mentioned problem, described manufacture method is characterised in that, the manufacture method of above-mentioned biological uptake thing, can be omitted in by ready-mixed operation before between above-mentioned processing face, continuous phase and decentralized photo.

In addition, the invention that the application's claim 7 relates to, by the manufacture method of the biological uptake thing described in any one of claims 1 to 3 is provided, solve above-mentioned problem, described manufacture method is characterised in that, the water system using in continuous phase is disperseed the water-phase component using in solvent or decentralized photo, is the pharmaceutically acceptable liquid such as water, buffer, ethanol, propylene glycol, dimethyl sulfoxide or methyl iso-butyl ketone (MIBK) or their mixture.

In addition, the invention that the application's claim 8 relates to, by the manufacture method of biological uptake thing claimed in claim 3 is provided, solve above-mentioned problem, described manufacture method is characterised in that, in the manufacture method of the liposome as biological uptake thing, at least either party of the processed mobility using in decentralized photo or continuous phase, contain natural and synthetic phospholipid matter, their hydrogenated derivatives and their mixture, apart from the above, also contain and be selected from following at least one: amphiphilic compound, ionic and nonionic surfactant, glycosphingolipid, physiological bile salt, saturated and unsaturated fatty acid or fatty alcohol, ethoxylated fatty acid or fatty alcohol, ester and ether with those materials, alkylaryl-Aethoxy Sklerol is tyloxapol such as, the ester of sugar or sugar alcohol and fatty acid or fatty alcohol and ether, acetylation or ethoxylation list-and two glyceride, synthesising biological decomposability polymer, ethoxylation dehydrated sorbitol ester or sorbitan ether, aminoacid, polypeptide and protein, sterols.

In addition, the invention that the application's claim 9 relates to, by the manufacture method of the biological uptake thing described in any one of claims 1 to 3 is provided, solve above-mentioned problem, described manufacture method is characterised in that, in the manufacture of biological uptake thing, reason is when mixing each processed liquid between face throughout, for air contained in processed liquid, the molten gas of oxygen etc., lower boiling organic solvent, steam etc. deposited are carried out to degassed or desolventizing, reduced pressure in the outside of each processing portion that above-mentioned each processing face is set.

In addition, the invention that the application's claim 10 relates to, by the manufacture method of the biological uptake thing described in any one of claims 1 to 3 is provided, solve above-mentioned problem, described manufacture method is characterised in that, in the manufacture of above-mentioned biological uptake thing, in the contained composition of decentralized photo, contain the material with phase transition temperature, be adjusted to the temperature range of phase transition temperature+5～+ 45 DEG C and than also low temperature of the boiling point of continuous phase by processing by the temperature of the thin film fluid forming between face.

In addition, the invention that the application's claim 11 relates to, by the manufacture method of biological uptake thing is provided, solve above-mentioned problem, described manufacture method is characterised in that, in the manufacture of above-mentioned biological uptake thing, in the contained composition of decentralized photo, contain the material with phase transition temperature, by processing the biological uptake thing chilling obtaining in the thin film fluid forming between with face below 35 DEG C and than also high temperature of the freezing point of continuous phase.

Be explained, " chilling " in the present invention, is defined as the processed liquid of cooling object, processes solvent in 60 seconds, reach target temperature and carry out cooling with every 1L.

According to the present invention, have between the processing that for processing, face, at least one party are rotated with respect to the opposing party face of approached separation of subtend configuration, can give equably energy (shearing force) to thin film fluid.And, can freely regulate the interval of the treated side that subtend arranges.Thus, compared with manufacture method in the past, biological uptake thing (liposome and microemulsion particle) that can be using low-yield acquisition as object particle diameter.Thereby, can provide that energy efficiency is high, productivity ratio is high, the manufacture method of safety, biological uptake thing that carrying capacity of environment is few.In addition, compared with the method for utilizing in the past, can stably obtain the uniform biological uptake thing of particle diameter.

In addition, the present invention, does not need the pre-treatment of ready-mixed (pre-dispersed processing) as manufacture method in the past etc. especially, can easily carry out the manufacture of biological uptake thing.

Brief description of the drawings

Fig. 1 (A) is the simple profilograph that represents the concept of the device using in the enforcement of the present application, (B) be the simple profilograph that represents the concept of other embodiment of said apparatus, (C) being the simple profilograph that represents the concept of the other embodiment of said apparatus, is (D) the simple profilograph that represents the concept of further other embodiment of said apparatus.

Fig. 2 (A)～(D) is respectively the simple profilograph of the concept of further other embodiment of presentation graphs 1 shown device.

Fig. 3 (A) is the simple upward view of the major part of Fig. 2 (C) shown device, (B) be the simple upward view of the major part of other embodiment of said apparatus, (C) be the simple upward view of the major part of other embodiment, (D) be the simple upward view that represents the concept of further other embodiment of said apparatus, (E) be the simple upward view that represents the concept of in addition further other embodiment of said apparatus, (F) be the simple upward view that represents the concept of the further other embodiment of said apparatus.

Fig. 4 (A)～(D) is respectively the simple profilograph of the concept of further other embodiment of presentation graphs 1 shown device.

Fig. 5 (A)～(D) is respectively the simple profilograph of the concept of further other embodiment of presentation graphs 1 shown device.

Fig. 6 (A)～(D) is respectively the simple profilograph of the concept of further other embodiment of presentation graphs 1 shown device.

Fig. 7 (A)～(D) is respectively the simple profilograph of the concept of further other embodiment of presentation graphs 1 shown device.

Fig. 8 (A)～(D) is respectively further other the simple profilograph of concept of embodiment of presentation graphs 1 shown device.

Fig. 9 (A)～(C) is respectively further other the simple profilograph of concept of embodiment of presentation graphs 1 shown device.

Figure 10 (A)～(D) is respectively further other the simple profilograph of concept of embodiment of presentation graphs 1 shown device.

Figure 11 (A) and (B) represent respectively the simple profilograph of the concept of further other embodiment of above-mentioned Fig. 1 shown device, (C) is the simple upward view of the major part of Fig. 1 (A) shown device.

Figure 12 (A) is about the compression face of Fig. 1 (A) shown device, represents the simple profilograph of the major part of other embodiment (B) to be the simple profilograph of the major part of further other embodiment of this device.

Figure 13 is the simple vertical section about company's pressure of contact surface imparting mechanism major parts 4, other embodiment of Figure 12 (A) shown device.

Figure 14 about on Figure 12 (A) shown device, be provided with temperature and regulate with the simple profilograph of major part big envelope, other embodiment.

Figure 15 is about the pressure of contact surface imparting mechanism 4 of Figure 12 (A) shown device, the further simple profilograph of the major part of other embodiment.

Figure 16 (A) is the simple drawing in side sectional elevation of the major part of further other embodiment of Figure 12 (A) shown device, (B) (C) (E)～(G) is the simple drawing in side sectional elevation of the major part of the other embodiment of this device, is (D) the simple profilograph of the local major part of the other embodiment of this device.

Figure 17 is the simple profilograph of the major part of further other embodiment of Figure 12 (A) shown device.

Figure 18 (A) is the simple profilograph that is illustrated in the concept of further other embodiment of the device using in the enforcement of the present application, is (B) key diagram of the local major part of this device.

Figure 19 (A) is that the 1st of Figure 12 (A) shown device is processed the top view of use portion, (B) is the profilograph of its major part.

Figure 20 (A) is the profilograph that the 1st and the 2nd of Figure 12 (A) shown device is processed the major part of use portion, is (B) profilograph that separates the major part of the above-mentioned the 1st and the 2nd processing use portion of slight gap.

Figure 21 (A) is the top view of other embodiment of above-mentioned the 1st processing use portion, (B) is the simple profilograph of its major part.

Figure 22 (A) is the top view of further other embodiment of above-mentioned the 1st processing use portion, (B) is the simple profilograph of its major part.

Figure 23 (A) is the top view of the other embodiment of the 1st processing use portion, is (B) top view of the further other embodiment of the 1st processing use portion.

Figure 24 (A) (B) (C) is respectively about the separation method of object being treated after treatment, represents the key diagram of the embodiment beyond above-mentioned.

Figure 25 is the skeleton diagram in the vertical section of the summary of the device for the present application is described.

Figure 26 (A) is the 1st simple top view of processing with face of Figure 25 shown device, is (B) the 1st expanded view of processing by the major part of face of Figure 25 shown device.

Figure 27 (A) is the profile on the 2nd importing road, is (B) for illustrating that the 2nd imports the expanded view of the major part of the processing face on road.

Figure 28 (A) and (B) be respectively the expansion profile of major part that is arranged at the inclined plane of processing use portion for illustrating.

Figure 29 is the figure that is arranged at the compression face of processing use portion for illustrating, is (A) upward view of the 2nd processing use portion, is (B) the expansion profile of the major part of the 1st and the 2nd processing use portion.

Detailed description of the invention

Below, biological uptake thing of the present invention and manufacture method thereof are described in detail, technical scope of the present invention, is not limited to following example and embodiment, can carry out various changes and implement.

As used in the present invention, thering is the method that obtains biological uptake thing in the thin film fluid that face, at least one processing that can be rotated with respect to the opposing party for processing that approach and separate that subtend arranges form between with face, for example, can use the device of the same principle of recording with the present patent application people's JP 2004-49957 communique.In above-mentioned thin film fluid, using liposome constituent and microemulsion constituent by as biological uptake thing, the solution of more than two kinds of the formation such as water system dispersion soln mixes, and obtains desirable biological uptake thing.

Below, the fluid treating device of the enforcement that is suitable for the method is described.

As shown in Fig. 1 (A), this device has 2 processing use portions 10,20 of the 1st and the 2nd of subtend, and at least one party's processing is rotated with portion.The two subtend faces of processing use portion 10,20, respectively as processing with face 1,2, carry out the processing of processed liquid between two processing are with face.The 1st processing has the 1st processing face 1, the 2 processing portion 20 with portion 10 and has the 2nd processing face 2.

Two processing are connected with the stream of processed liquid with face 1,2, form a part for the stream of processed liquid.

More specifically, this device forms the stream of at least 2 processed liquids, makes each passage confluent simultaneously.

That is, the stream of this device and the 1st processed liquid connects, and forms a part for the stream of the 1st processed liquid, forms a part for the stream of the 2nd processed liquid except the 1st processed liquid simultaneously.And this device makes two passage confluents, processing with 1,2, face, mix two fluids, with reaction in the situation that, make its reaction.In the embodiment shown in Fig. 1 (A), above-mentioned each stream is sealed, and forms liquid-tight (situation that processed liquid is liquid) airtight (situation that processed liquid is gas).

If specifically described, as shown in Fig. 1 (A), this device has: the 1st bracket 11 of use portion 10 is processed in the 1st above-mentioned processing use portion 10, above-mentioned the 2nd processing use portion 20, maintenance the 1st, keeps the 2nd bracket 21, pressure of contact surface imparting mechanism 4, rotary driving part, the 1st introduction part d1, the 2nd introduction part d2, fluid pressure imparting mechanism p1, the 2nd fluid supply unit p2 and the housing 3 of the 2nd processing use portion 20.

Be explained, rotary driving part omits diagram.

The 1st at least either party who processes use portion 10 and the 2nd processing portion 20 can separate with respect to the opposing party is approaching at least arbitrarily, and two processing can approach separation with face 1,2.

In the present embodiment, the 2nd process use portion 20 with respect to the approaching separation of the 1st processing use portion 10.But, also can be in contrast, the 1st processes use portion 10 processes the approaching separation of use portion 20 with respect to the 2nd, also can 10,20 separation close to each other of two processing use portions.

The 2nd processes and is configured in the 1st with portion 20 and processes the top of use portion 10, and the 2nd processes the face downward of use portion 20, i.e. lower surface, for the above-mentioned the 2nd processing with the face upward of face 2, the 1 processing use portions 10, above, be the 1st above-mentioned processing face 1.

As shown in Fig. 1 (A), in the present embodiment, the 1st processing is respectively ring bodies, i.e. annulus with portion 10 and the 2nd processing portion 20.Below, as required, claim that the 1st processing portion 10 is the 1st annulus 10, claim that the 2nd processing portion 20 is the 2nd annulus 20.

In the present embodiment, two annulus the 10, the 20th, metal one end by mirror ultrafinish member, process and process with face 2 with face 1 and the 2nd as the 1st using this minute surface.That is, process with face 1 as the 1st the upper surface of the 1st annulus 10, and by mirror ultrafinish, process with face 2, by mirror ultrafinish as the 2nd the lower surface of the 2nd annulus 20.

At least one party's bracket can relatively be rotated with respect to the opposing party's bracket by rotary driving part.50 of Fig. 1 (A) represents the rotating shaft of rotary driving part.In rotary driving part, can adopt motor.By rotary driving part, can make the processing face of a side annulus relatively be rotated with respect to the processing face of the opposing party's annulus.

In the present embodiment, the 1st bracket 11 is subject to the driving force from rotary driving part by rotating shaft 50, is rotated with respect to the 2nd bracket 21, and like this, and the 1st bracket 11 shape all-in-one-piece the 1st annulus 10 rotate with respect to the 2nd annulus 20.In the inner side of the 1st annulus 10, rotating shaft 50 is arranged on the 1st bracket 11 as follows, that is, and and while overlooking, with the centres of the 1st annulus 10 of circle.

The rotation of the 1st annulus 10 is centered by the axle center of the 1st annulus 10.Though not shown, still, axle center refers to the centrage of the 1st annulus 10, is imaginary line.

As mentioned above, in the present embodiment, the 1st bracket 11 is processed the 1st of the 1st annulus 10 and is used face 1 upward, keeps the 1st annulus 10, the 2 brackets 21 that the 2nd of the 2nd annulus 20 is processed and uses face 2 downward, keeps the 2nd annulus 20.

Particularly, the 1st and the 2nd bracket 11,21 has respectively the annulus resettlement section of concavity.In the present embodiment, the 1st annulus 10 is embedded in the annulus resettlement section of the 1st bracket 11, and the 1st annulus 10 is fixed on annulus resettlement section, can not haunt from the annulus resettlement section of the 1st bracket 11 making.

, above-mentioned the 1st processing is exposed from the 1st bracket 11 with face 1, towards the 2nd bracket 21 sides.

The material of the 1st annulus 10, except metal, also can adopt to pottery, sintering metal, abrasion performance steel, other metal have been implemented the material of cured, hard material is carried out liner, coating, carried out the material of plating etc.Particularly, because rotation preferably forms the 1st handling part 10 with the raw material of lightweight.About the material of the 2nd annulus 20, also can adopt the material identical with the 1st annulus 10.

On the other hand, can haunt and accommodate the face 2 for processing of the 2nd annulus 20 in the annulus resettlement section 41 that the 2nd bracket 21 has.

The annulus resettlement section 41 that the 2nd bracket 21 has be accommodate the 2nd annulus 20, be mainly and process with the recess at face 2 positions, side opposition side, rounded in the time overlooking, form the groove of ring-type.

The size of annulus resettlement section 41 is larger than the 2nd annulus 20, and has enough intervals between the 2nd annulus 20, accommodates the 2nd annulus 20.

By this interval, in this annulus resettlement section 41, the 2nd annulus 20 can be at the direction of principal axis of the annulus resettlement section 41 of ring-type and in the direction displacement intersecting with this direction of principal axis.In other words,, by this interval, the 2nd annulus 20 can make the centrage of the 2nd annulus 20 with respect to 41 displacements of annulus resettlement section with change and the mode of the axial parallel relation of above-mentioned annulus resettlement section 41.

Below, by the 2nd bracket 21 by the 2nd annulus 20 around position be called middle body 22.

For above-mentioned explanation, in other words, the 2nd annulus 20 is housed in annulus resettlement section 41 as follows,, can be the above-mentioned direction displacement of haunting in the thrust direction of annulus resettlement section 41, in addition, can be in the direction displacement with respect to 41 center, annulus resettlement section bias.And the 2nd annulus 20 is accommodated as follows, that is, with respect to annulus resettlement section 41, in each position of the Zhou Fangxiang of the 2nd annulus 20, can be with the amplitude of haunting from annulus resettlement section 41 different mode displacement respectively, that is, and can center runout.

Although the 2nd annulus 20 has the degree of freedom of above-mentioned 3 displacements,, the degree of freedom of the direction of principal axis of 2nd annulus 20 relative with annulus resettlement section 41, eccentric direction, center runout direction, but the 2nd annulus 20 remains on the 2nd bracket 21 in the mode of not rotating with the 1st annulus 10.Though not shown, relevant this point, as long as arrange respectively the suitable protuberance of the rotation that is limited in its week direction on annulus resettlement section 41 and the 2nd annulus 20 with respect to annulus resettlement section 41.But this protuberance must not destroy the degree of freedom of above-mentioned 3 displacements.

Above-mentioned pressure of contact surface imparting mechanism 4 is along making the 1st processing face 1 and the approaching direction of the 2nd processing face 2 give power to processing portion.In the present embodiment, pressure of contact surface imparting mechanism 4 is arranged on the 2nd bracket 21, and the 2nd annulus 20 is suppressed to the 1st annulus 10.

Pressure of contact surface imparting mechanism 4 by each position of the Zhou Fangxiang of the 2nd annulus 20, the 2nd process with suppressing to the 1st annulus 10 equably each position of face 2.The concrete structure of pressure of contact surface imparting mechanism 4 is described in detail in the back.

As shown in Fig. 1 (A), above-mentioned housing 3 is configured in the outside of two annulus 10,20 outer peripheral faces, accommodates product, and this product generates and be discharged to the outside of two annulus 10,20 between processing with face 1,2.As shown in Fig. 1 (A), housing 3 is the liquid-tight containers of accommodating the 1st bracket 11 and the 2nd bracket 21.But the 2nd bracket 21 can be used as a part for this housing and forms to implement with housing 3.

As mentioned above, needless to say form the situation of a part for housing 3, though with housing 3 splits form in the situation that, the 2nd bracket 21 is not movable too, to make can not affect the interval of 10,20 of two annulus, that is, two process with the interval between faces 1,2.In other words, the 2nd bracket 21 can not exert an influence with the interval between face 1,2 to two processing.

On housing 3, the outside of housing 3 is provided with the outlet 32 for discharging product.

The 1st introduction part d1 to two processing with supplying with the 1st processed liquid between face 1,2.

Above-mentioned fluid pressure imparting mechanism p1 is connected with the 1st introduction part d1 directly or indirectly, gives fluid pressure to the 1st processed liquid.In fluid pressure imparting mechanism p1, can adopt compressor, other pump.

In this embodiment, the 1st introduction part d1 is arranged on the fluid passage of above-mentioned middle body 22 inside of the 2nd bracket 21, and its one end is at the center opening for the 2nd annulus 20 of circle of overlooking of the 2nd bracket 21.In addition, the other end of the 1st introduction part d1 is in the outside of the 2nd bracket 21, the outside of housing 3 is connected with above-mentioned fluid pressure imparting mechanism p1.

The 2nd introduction part d2 is to processing the 2nd liquid mixing with the 1st processed liquid with 1,2 supply of face.In this embodiment, the 2nd introduction part is the fluid passage that is arranged on the 2nd annulus 20 inside, and process with face 2 openings the 2nd its one end, and its other end is connected with the 2nd fluid supply unit p2.

In the 2nd fluid supply unit p2, can adopt other pumps such as compressor.

Be imported into the space of the inner side of two annulus 10,20 by the 1st processed liquid of fluid pressure imparting mechanism p1 pressurization from the 1st introduction part d1, process with face 1 and the 2nd and process with between face 2 by the 1st, pass from the outside of two annulus 10,20.

Now, the 2nd annulus 20 that is subject to the discharge pressure of the 1st processed liquid overcomes suppressing of pressure of contact surface imparting mechanism 4, away from the 1st annulus 10, makes two processing with separating small interval between face.About because two processing are with the interval that approaches 1,2, two sides that separation forms of face 1,2, after describe in detail.

At 1,2, face for two processing, supply with the 2nd processed liquid and collaborate with the 1st processed liquid from the 2nd introduction part d2, utilize the rotation of processing with face to promote mixing (reaction).Then the product that, the mixing of two liquids (reaction) generates is discharged to the outside of two annulus 10,20 from two processing face 1,2.The product of discharging in two annulus 10,20 outsides is finally discharged to the outside (oneself discharges) of housing 3 by the outlet 32 of housing 3.

The mixing of above-mentioned processed liquid and reaction (with reaction in the situation that), by with respect to the 2nd the 1st rotation being produced by drive division 5 of processing with portion 10 of processing with portion 20, are carried out with face 1 and the 2nd processing face 2 in the 1st processing.

Process with between face 1,2 the 1st and the 2nd, the downstream of the peristome m2 of the 2nd introduction part d2 forms the process chamber that above-mentioned the 1st processed liquid and the 2nd processed liquid are mixed.Particularly, at 1,2, face for two processing, the inward-outward direction r1 of the 2nd annulus 20 diameters that represent with oblique line in the Figure 11 (C) of bottom surface that represents the 2nd annulus 20 is upper, and the peristome m2 of the 2nd introduction part i.e. exterior lateral area H of the 2nd peristome m2 brings into play function as above-mentioned process chamber.Therefore, this process chamber is positioned at the two peristome m1 of the 1st introduction part d1 and the 2nd introduction part d2, the downstream of m2 in two processing with 1,2, face.

Be directed into the 2nd processed liquid of 1,2, two processing face from the 2nd peristome m2, in the region H of above-mentioned formation processing chamber, mix two processed liquids reactions with reaction in the situation that with the 1st processed liquid being directed between two processing face 1,2 in the space from the 1st peristome m1 process annulus inner side.Liquid is subject to discharge pressure by fluid pressure imparting mechanism p1, and in the outer side shifting towards annulus in the slight gap of 1,2, face for two processing, but, because the 1st annulus 10 rotates, so, in above-mentioned conversion zone H, mixed liquid is not to move point-blank laterally from inner side in the inward-outward direction of circle diameter, but overlooking processing with under the state of face, centered by the rotating shaft of annulus, move laterally from the inner side of annulus vortex shape.Like this, mixing the region H of (reaction), move laterally from the inner side of annulus by helically, thereby can guarantee in the slight gap of 1,2, two processing face, to there is the needed interval of sufficient mixing (reaction), can promote uniform mixing.

In addition, mix product that (reaction) produce at the above-mentioned the small the 1st and the 2nd product of processing with formation homogenizing between face 1,2, particularly in crystallization, form microgranule separate out in the situation that.

At least, on the basis of the centrifugal equilibrium of forces producing in discharge pressure, the elastic force pressure of above-mentioned pressure of contact surface imparting mechanism 4 and the rotation of annulus of above-mentioned fluid pressure imparting mechanism p1 load, can make the interval balance between two processing face 1,2 is preferred slight gap, and, be subject to the processed liquid of the centrifugal force that the discharge pressure of fluid pressure imparting mechanism p1 load and the rotation of annulus produce, vortex shape ground, promotes to mix (reaction) with moving in the slight gap between face 1,2 in above-mentioned processing.

The rotation of the discharge pressure of above-mentioned mixing (reaction) by fluid pressure imparting mechanism p1 load, annulus and carrying out forcibly.That is, mix (reaction) approaching 1,2, face of subtend processing that arrange and that at least one party is rotated with respect to the opposing party discretely, evenly occur forcibly.

So, particularly, by the crystallization of the product that produces of reaction or separate out, can by the rotary speed of the adjustment of the discharge pressure of fluid pressure imparting mechanism p1 load, annulus be the adjustment of rotating speed of annulus such, control than the method that is easier to control.

Like this, this fluid treating device, by the adjustment of discharge pressure, centrifugal force, the processing of carrying out that the size of product the is affected control at the interval of 1,2, face, and, excellence aspect the control of the distance moving in the above-mentioned conversion zone H that the even generation of product is affected.

In addition, the product of above-mentioned processing is not limited to the situation that product is separated out, and also comprises the situation of liquid.In addition, in the case of the fine solids that product is microgranule etc., product also can precipitate in fluid after treatment, in addition, also can be in the state of the dispersion liquid that in continuous phase, decentralized photo exists.

Be explained, rotating shaft 50 is not limited to arranged perpendicular, also can horizontal direction configure also tiltable configuration.In processing, be illustrated as the situation of mixing (reaction) in the slight gap of 1,2, two processing face, this is because can get rid of in fact the impact of gravity.

Shown in Fig. 1 (A), the 1st introduction part d1 is in the 2nd bracket 21, consistent with the axle center of the 2nd annulus 20, up and down vertical the mechanism of extending.But, the 1st introduction part d1 is not limited in consistent with the axle center of the 2nd annulus 20, as long as supplying with the 1st processed liquid in the space that can surround to two annulus 10,20, also can be arranged on other position of the middle body 22 of the 2nd bracket 21, and, can be also that non-perpendicular inclination is extended.

Figure 12 (A) represents the preferred embodiment of said apparatus.As shown in the figure, the 2nd processes and has the above-mentioned the 2nd with portion 20 and process with face 2, has compression face 23 simultaneously, this compression face 23 be positioned at the 2nd process with the inner side of face 2 and with the 2nd process the face of using 2 adjacency.Below, this compression face 23 is called again the adjustment face 23 of using that separates.As shown in the figure, this separation is inclined plane with adjustment face 23.

As previously mentioned, in the bottom of the 2nd bracket 21, i.e. bottom, form annulus resettlement section 41, in this annulus resettlement section 41, contain the 2nd and process use portion 20.In addition, though do not illustrate, by rotation stopping device, the 2nd processing portion 20 is not accommodated rotatably with respect to the 2nd bracket 21.The 2nd above-mentioned processing is exposed from the 2nd bracket 21 with face 2.

In this embodiment, process with 1,2, face, the 1st process and process be object being treated with the inner side of portion 20 inflow portion, the outflow portion that the 1st processing is object being treated with portion 10 and the 2nd processing with the outside of portion 20 with portion 10 and the 2nd.

Above-mentioned pressure of contact surface imparting mechanism 4 is processed with face 1 with crimping or approaching state pushing the 2nd processing face 2 with respect to the 1st, the power that makes separation between two processing faces 1,2 by this pressure of contact surface and fluid pressure etc. balanced, forms the thin film fluid of regulation thickness.In other words,, by the equilibrium of above-mentioned power, two process the slight gap that remains regulation with the interval of 1,2, face.

Particularly, in this embodiment, pressure of contact surface imparting mechanism 4 is made up of following part: above-mentioned annulus resettlement section 41; Clockwork spring resettlement section 42, the inside that this clockwork spring resettlement section 42 is arranged on annulus resettlement section 41 is the bosom of annulus resettlement section 41; Spring 43; With air introduction part 44.

But, pressure of contact surface imparting mechanism 4 also can have in above-mentioned annulus resettlement section 41, above-mentioned clockwork spring resettlement section 42, spring 43 and air introduction part 44 at least any one.

Use portion 20 matched in clearance are processed in annulus resettlement section 41 and the 2nd, to make the 2nd in annulus resettlement section 41 process dark or shallow ground, position, the i.e. upper and lower displacement of use portion 20.

The inside butt of one end of above-mentioned spring 43 and clockwork spring resettlement section 42, the processing of the 2nd in the other end of spring 43 and annulus resettlement section 41 is top butt with the front portion of portion 20.In Fig. 1, though spring 43 only shows 1, process the various piece of use portion 20 but preferably push the 2nd by multiple springs 43., this is because by increasing the number of spring 43, can give the 2nd and process the more impartial pushing force of use portion 20.So, for the 2nd bracket 21, be preferably several compound to dozens of spring 43 be installed.

In this embodiment, can by above-mentioned air introduction part 44 to annulus resettlement section 41 interior importing air.By the importing of such air, between annulus resettlement section 41 and the 2nd processing use portion 20, as compression chamber, give 2nd as pushing force using spring 43 together with air pressure and process use portion 20.Therefore,, by adjusting the air pressure importing from air introduction part 44, in capable of regulating running, the 2nd processes with face 2 with respect to the 1st pressure of contact surface of processing with face 1.Be explained, also can replace utilize air pressure air introduction part 44, utilize the mechanism that produces pushing force by other the fluid pressure such as oil pressure to implement.

Pressure of contact surface imparting mechanism 4 is a part for pressure of contact surface except supplying with, regulating above-mentioned pushing force, also doubles as shift adjusting machine and buffer gear.

Specifically, pressure of contact surface imparting mechanism 4 is as shift adjusting machine, followed while starting, stretching, extension axially in running, worn away caused axial displacement by the adjustment of air pressure, can maintain the pushing force at initial stage.In addition, as mentioned above, pressure of contact surface imparting mechanism 4 movable keeps the 2nd to process the relocation mechanism of use portion 20 by adopting, and also brings into play function as the buffer gear of locating as micro-vibration, rotation.

Then,, for the state of use of blood processor that adopts above-mentioned formation, describe according to Fig. 1 (A).

First, the 1st processed liquid is subject to the discharge pressure from fluid pressure imparting mechanism p1, imports the inner space of the housing being sealed from the 1st introduction part d1.On the other hand, by the rotation of the rotating shaft 50 that produced by rotary driving part, the 1st processes and rotates with portion 10.Thus, the 1st processing is relatively rotated under the state that keeps slight gap with face 1 and the 2nd processing face 2.

The 1st processed liquid uses 1,2, faces to form thin film fluids in two processing that keep slight gap, and the 2nd processed liquid importing from the 2nd introduction part d2 collaborates with 1,2, face and this thin film fluid in two processing, forms equally a part for thin film fluid.By this interflow, the 1st and the 2nd processed liquid mixes and formation product.And, two liquid reactions with reaction in the situation that, reaction is uniformly promoted, and forms this product.Thus, can generate more equably fine particle with separate out in the situation that, even without separate out in the situation that, still can realize uniform admixture (reaction uniformly with reaction in the situation that).Be explained, can think the product of separating out due to the 1st process with the rotation of face 1 and the 2nd processing sheared between with face 2, sometimes by further microminiaturization.At this, by the 1st processing is adjusted into 1 μ m to 1mm, the particularly slight gap of 1 μ m to 10 μ m with face 1 and the 2nd processing with the interval of face 2, thereby can realize uniform admixture (with reaction uniformly in the situation of reaction), meanwhile, can generate the ultra micron of number nm unit.

Product, from 1,2 discharges of face for two processing, is discharged to hull outside from the outlet 32 of housing 3.The product of discharging forms vaporific in vacuum or the environment that reduced pressure by known decompressor, after the other parts of encountering in environment, flow down as liquid, and the liquid object can be used as after degasification reclaims.

Be explained, in this embodiment, though blood processor has housing 3, such housing 3 also can be set and implement.For example, the decompression tank that degasification is used can be set, i.e. vacuum tank, implements at this tank internal configurations blood processor.In this case, on blood processor, certainly do not there is above-mentioned outlet.

As mentioned above, can process the slight gap that is adjusted into mechanical interval and sets the μ m unit that can not reach with face 1 and the 2nd processing with the interval of face 2 by the 1st, its mechanism is described as follows.

The 1st processing can relatively approach and separate with face 1 and the 2nd processing face 2, and is relatively rotated.In this embodiment, the 1st processes and rotates with face 1, and the 2nd processes to have with face 2 and movably construct (floating structure) at direction of principal axis, process with the approaching separation of face 1 with respect to the 1st.

Therefore, in this embodiment, the 2nd process with the direction of principal axis position of face 2 by power, above-mentioned pressure of contact surface with separate equilibrium of forces, be set as the precision of μ m unit, processes thus the setting of the slight gap of 1,2, use face.

As shown in Figure 12 (A), as pressure of contact surface, can enumerate following: in pressure of contact surface imparting mechanism 4, the air pressure of giving from air introduction part 44, i.e. this pressure the situation of malleation, the pushing force of spring 43.

Be explained, in the embodiment shown in Figure 12～15, for avoiding the numerous and diverse of drawing, the 2nd introduction part d2 omits and is described.About this point, also can regard the section of the position that the 2nd introduction part d2 is not set as.In addition, in figure, U represents top, and S represents below.

On the other hand, as separating force, can enumerate following: act on the compression face of separation side, i.e. the 2nd processing face 2 and the separation fluid pressure on adjustment face 23, the 1st and process this negative pressure under the centrifugal force producing with the rotation of portion 10 and the situation that air introduction part 44 is applied to negative pressure.

Be explained, in the time that device is cleaned, put on the negative pressure of above-mentioned air introduction part 44 by increase, can strengthen the separation of two processing face 1,2, can easily clean.

And, by the equilibrium of these power, make the 2nd processing face 2 carry out stabilisation with the position that separates the slight gap of regulation with respect to the 1st processing face 1, realize thus the setting of the precision of μ m unit.

Separating force is illustrated in further detail.

First, about fluid pressure, in airtight stream the 2nd process with the pressure of sending into that portion 20 is subject to the processed liquid that comes from fluid pressure imparting mechanism p1 be fluid pressure.Now, with the 1st in stream process with in the face of to face, the 2nd process with face 2 with separate the compression face that becomes separation side with adjustment face 23, fluid pressure action on this compression face, generation because of the caused separating force of fluid pressure.

Secondly, about centrifugal force, if the 1st process use portion 10 high speed rotating, centrifugal action is in fluid, and a part for this centrifugal force becomes separating force, this separating force act on two processing faces 1,2 mutual away from direction on.

And in the case of processing and give negative pressure with portion 20 to the 2nd from above-mentioned air introduction part 44, this negative pressure works as separating force.

Above, in the application's invention, be that separating force describes by making the 1st and the 2nd processing with the masterpiece that face 1,2 is separated from each other, not the power of above-mentioned expression is got rid of from separating force.

As mentioned above, in the stream of the processed liquid being sealed, be situated between by the processed liquid of processing with 1,2, face, the pressure of contact surface that formation separating force is realized with pressure of contact surface imparting mechanism 4 reaches balanced state, realize uniform admixture in two processing with 1,2, face thus, with reaction in the situation that, realize reaction uniformly, form the thin film fluid that is applicable to the crystallization that carries out fine product simultaneously.Like this, this device, by being situated between forcibly by thin film fluid with 1,2, face in two processing, can maintaining the slight gap that can not realize in mechanical device in the past that is spaced apart of 1,2, two processing face, thereby realize the microgranule generating accurately as product.

In other words, process the thickness with the thin film fluid of 1,2, face, be adjusted to desirable thickness by the adjustment of above-mentioned separating force and pressure of contact surface, can carry out the realization of necessary uniform admixture (reaction uniformly with reaction in the situation that) and the generation processing of fine product.Therefore, in the case of will forming the thickness of little thin film fluid, as long as adjust pressure of contact surface or separating force to make pressure of contact surface for the relative increase of separating force, on the contrary, in the case of will forming the thickness of large thin film fluid, as long as adjustment pressure of contact surface or separating force are so that must relatively increase for pressure of contact surface by separating force.

In the situation that increasing pressure of contact surface, in pressure of contact surface imparting mechanism 4, giving air pressure from air introduction part 44 is malleation, or, spring 43 is changed to the spring that pushing force is large or increases its number.

In the situation that increasing separating force, can increase the pressure of sending into of fluid pressure imparting mechanism p1, or increase by the 2nd area of processing with face 2, separation adjustment face 23, in addition in addition, can also adjust the 1st processing rotation of portion 10 centrifugal force is increased, or reduce the pressure from air introduction part 44.Or can give negative pressure.Spring 43 is as producing the thrust clockwork spring of pushing force at prolonging direction, still, can be also as the pulling force clockwork spring that produces power at shrinkage direction, can form part or all of formation of pressure of contact surface imparting mechanism 4.

In the situation that reducing separating force, can reduce the pressure of sending into of fluid pressure imparting mechanism p1, or reduce by the 2nd area of processing with face 2, separation adjustment face 23, in addition in addition, can also adjust the 1st processing rotation of portion 10 centrifugal force is reduced, or increase the pressure from air introduction part 44.Or also can reduce negative pressure.

And the key element reducing as the increase of pressure of contact surface and separating force, except above-mentioned, also can add the character of the processed liquid of viscosity etc., the adjustment of the character of so processed liquid also can be used as the adjustment of above-mentioned key element and carries out.

Be explained, in separating force, the compression face that acts on separation side the 2nd is processed with face 2 and separates with the fluid pressure on adjustment face 23, can be regarded as the power that forms the opening force in mechanical seal.

In mechanical seal, the 2nd processes and is equivalent to sealing ring with portion 20, but is processing apply fluid pressure with portion 20 in the situation that the 2nd, and in the time separating the 2nd processing and play a role by the power of portion 20 with portion 10 from the 1st processing, this power is opening force.

More specifically, the 1st embodiment described above is such, when processing with the compression face of separation side being only set in portion 20, the 2nd processing with face 2 and separate with adjustment face 23 in the case of the 2nd, sends into whole formation opening forces of pressure.What be explained is, when also arranging compression face by the rear side of portion 20 in the 2nd processing, particularly, the in the situation that of Figure 12 described later (B) and Figure 17, sending in pressure, the poor opening force that forms of the power playing a role as separating force and the power playing a role as pressure of contact surface.

At this, use Figure 12 (B) to describe the 2nd processing other embodiment of portion 20.

As shown in Figure 12 (B), processing the position of exposing with the annulus resettlement section 41 of portion 20 and in inner peripheral surface side, it is the approaching use adjustment face 24 of upper side that installation surface is processed with the opposition side of face 2 to the 2nd from the 2nd.

, in this embodiment, pressure of contact surface imparting mechanism 4 is by annulus resettlement section 41, air introduction part 44 and above-mentionedly approachingly form with adjustment face 24.But, pressure of contact surface imparting mechanism 4 also can only possess above-mentioned annulus resettlement section 41, above-mentioned clockwork spring resettlement section 42, spring 43, air introduction part 44 and above-mentioned approaching with in adjustment face 24 at least any one.

This approaches and is subject to being applied to the authorized pressure on processed liquid with adjustment face 24, generation makes the 2nd processing face 2 process to the 1st the power moving by the approaching direction of face 1, as the part approaching with pressure of contact surface imparting mechanism 4, the effect of taking on the supply side of pressure of contact surface.On the other hand, the 2nd processes with face 2 and above-mentioned separating with adjustment face 23, be subject to being applied to the authorized pressure on processed liquid, be created in and make the 2nd to process with face 2 and process the power moving by the direction that face 1 separates from the 1st, take on the effect for the supply side of the part of separating force.

Approach with adjustment face 24, the 2nd and process with face 2 and separate the compression face that is the discharge pressure that is subject to above-mentioned processed liquid with adjustment face 23, according to its direction, realize the above-mentioned pressure of contact surface different effect such from producing separating force that produce.

The approaching projected area A1 with adjustment face 24 and the Area Ratio A1/A2 that adds up to area A 2 are called equilibrium ratio K, important to the adjustment of above-mentioned opening force, wherein, approach with the projected area A1 of adjustment face 24 be with process the direction that separates with approaching of face, the i.e. approaching projected area with adjustment face 24 of projection on the orthogonal imaginary plane of the direction of haunting of the 2nd annulus 20, adding up to area A 2 is the 2nd the processing the 2nd of use portion 20 and process the total area of using face 2 and separation to use the projected area of adjustment face 23 of projection on this imaginary plane.

Approach and use the front end of adjustment face 24 and separate the front end with adjustment face 23, the 2nd processing inner peripheral surface 25 of portion 20 that is together limited at ring-type is on front end of line L1.Therefore,, by determining to approach the position with the cardinal extremity line L2 of adjustment face 24, can carry out the adjustment of equilibrium ratio K.

; in this embodiment; processedly send pressure as opening force with liquid in the case of utilizing; be greater than and approach the projected area of using adjustment face 24 by making the 2nd processing face 2 and separating by the total projected area of adjustment face 23, can produce the opening force corresponding with its area ratio.

For above-mentioned opening force, change above-mentioned balanced line, approach by the area A 1 of adjustment face 24, thus, can be by the pressure of processed liquid, fluid pressure is adjusted.

Sliding surface real surface pressure P, the surface pressing that fluid pressure in pressure of contact surface produces can calculate with following formula.

P＝P1×(K-k)+Ps

In formula, P1 represents the pressure of processed liquid, i.e. fluid pressure, and K represents above-mentioned equilibrium ratio, and k represents opening force coefficient, and P s represents spring and back pressure.

Adjust sliding surface real surface pressure P by the adjustment of this balanced line, make thus to process by 1,2 desirable slight gap amounts of formation of face, form the film that processed liquid produces, make product become fine, mix uniformly (reaction).

Conventionally, if the less thick of the thin film fluid between face 1,2 for two processing can make product thinner.On the contrary, large if the thickness of thin film fluid becomes, to process and become coarse, the treating capacity of time per unit increases.So, by the adjustment of above-mentioned sliding surface real surface pressure P, can adjust the interval of 1,2, two processing face, can realize desirable even admixture (with reaction uniformly in the situation of reaction), obtain fine product simultaneously.Below, claim that sliding surface real surface pressure P is surface pressing P.

Conclude this relation, in the situation that above-mentioned product is thick, can reduce equilibrium ratio, reduce surface pressing P, increase above-mentioned interval, increase the thickness of above-mentioned thin film fluid.On the contrary, in the situation that above-mentioned product is thinner, can increase equilibrium ratio K, increase surface pressing P, reduce above-mentioned interval, reduce the thickness of above-mentioned thin film fluid.

Like this, as a part for pressure of contact surface imparting mechanism 4, form and approach with adjustment face 24, by the position of its balanced line, can implement the adjustment of pressure of contact surface, capable of regulating is processed with the interval between face.

In the adjustment at above-mentioned interval, as mentioned above, consider by changing the pushing force of above-mentioned spring 43, the air pressure of air introduction part 44 is carried out.In addition, fluid pressure be processed liquid discharge pressure adjustment and become centrifugal force adjustment the 1st process the adjustment that use portion 10 is the rotation of the 1st bracket 11, be also important adjustment key element.

As mentioned above, this device forms as follows,, process with portion 20 and with respect to the 2nd and process the 1st processing use portion 10 being rotated with portion 20 for the 2nd, by obtaining the pressure balance of sending into pressure, this rotary centrifugal force and pressure of contact surface of processed liquid, at the thin film fluid that forms regulation on face for two processing.In addition, at least one party of annulus is as floating structure, and the danger of caused abrasion of contact etc. is got rid of in the location of absorbent cores vibration etc.

In the embodiment of this Figure 12 (B), for the formation possessing beyond above-mentioned adjustment face, the same with the embodiment shown in Fig. 1 (A).

In addition, in the embodiment shown in Figure 12 (B), as shown in figure 17, above-mentioned separation adjustment face 23 also can be set and implement.

Embodiment shown in Figure 12 (B), Figure 17, arranging approach with adjustment face 24 in the situation that, be greater than above-mentioned area A 2 by making to approach by the area A 1 of adjustment face 24, thereby do not produce opening force, on the contrary, the authorized pressure being applied on processed liquid all works as pressure of contact surface.Also such setting can be carried out, in this case, by increasing other separating force, 1,2 equilibriums of two processing face can be made.

Determined to act on by above-mentioned Area Ratio and make the 2nd to process with face 2 from the 1st power of processing with face 1 detaching direction, this masterpiece is making a concerted effort of the power suffered from fluid.

In above-mentioned embodiment, as mentioned above, spring 43 gives uniform stress for sliding surface is processed with face, number is installed The more the better.But this spring 43 also can be as shown in Figure 13, adopts monovolume geometric pattern spring.It is 1 convoluted spring as shown in the figure, that center is concentric with the 2nd processing use portion 20 of ring-type.

The 2nd processes with sealing to become airtight mode between portion 20 and the 2nd bracket 21, and sealing can adopt known means.

As shown in figure 14, in the 2nd bracket 21, be provided with big envelope 46 for temperature adjustment, this temperature adjustment is cooling or heating the 2nd processing use portion 20 with big envelope 46, its temperature of scalable.And 3 of Figure 14 represents above-mentioned housing, in this housing 3, the temperature that is also provided with same object regulates with big envelope 35.

The temperature of the 2nd bracket 21 regulate with big envelope 46 are water cycle use spaces, this water cycle is formed at the side of the annulus resettlement section 41 in the 2nd bracket 21 with space, and be connected with the passage 47,48 of the 2nd bracket 21 exterior.A wherein direction temperature adjustment of passage 47,48 imports medium cooling or heating use with big envelope 46, and wherein the opposing party discharges this medium.

In addition, the temperature adjustment of housing 3 is by the passage of water for heating or cooling water with big envelope 35, and the covering part 34 of its periphery by being arranged on covering shell 3 is arranged between the outer peripheral face and this covering part 34 of housing 3.

In this embodiment, the 2nd bracket 21 and housing 3 possess said temperature adjustment big envelope, still, such big envelope also can be set in the 1st bracket 11.

As a part for pressure of contact surface imparting mechanism 4, except above-mentioned, cylinder mechanism 7 as shown in figure 15 also can be set.

This cylinder mechanism 7 has: cylinder space portion 70, and this cylinder space portion 70 is arranged in the 2nd bracket 21; Connecting portion 71, this connecting portion 71 connects cylinder space portion 70 and annulus resettlement section 41; Piston body 72, this piston body 72 is housed in cylinder space portion 70 and by connecting portion 71 and the 2nd processing portion 20 and is connected; The 1st nozzle 73, the 1 nozzles 73 are connected with the top of cylinder space portion 70; The 2nd nozzle 74, the 2 nozzles 74 connect the bottom of cylinder space portion 70; Pushing body 75, this pushing body 75 is the clockwork spring between cylinder space portion 70 tops and piston body 72 etc.

Piston body 72 can slide up and down in cylinder space portion 70, and by this slip of piston body 72, the 2nd processing slides up and down with portion 20, thereby the variable the 1st processes with the interval between face 1 and the 2nd processing face 2.

Though not shown, particularly, the pressure source of compressor etc. is connected with the 1st nozzle 73, applying air pressure by the top of the piston body 72 in from the 1st nozzle 73 to cylinder space portion 70 is malleation, piston body 72 is slided downwards, can make the 1st and the 2nd processing narrow with the interval between face 1,2.In addition, though not shown, the pressure source of compressor etc. is connected with the 2nd nozzle 74, applying air pressure by the below of the piston body 72 in from the 2nd nozzle 74 to cylinder space portion 70 is malleation, piston body 72 is slided upward, thereby can make the 2nd processing portion 20 move towards expanding the 1st and the 2nd processing direction that direction at the interval between face 1,2 is opened.Like this, utilize the air pressure obtaining from nozzle 73,74, capable of regulating pressure of contact surface.

Even if process with having enough spaces between the top of portion 20 and the topmost of annulus resettlement section 41 the 2nd in annulus resettlement section 41, by with the topmost 70a butt of cylinder space portion 70 set piston body 72, the topmost 70a of this cylinder space portion 70 also defines the upper limit of the width at the interval of 1,2, two processing face.That is, piston body 72 is processed the separation suppressing portion separating with face 1,2 and plays a role as inhibition two with the topmost 70a of cylinder space portion 70, in other words, plays a role with the mechanism that the maximum at the interval between face 1,2 is separately measured as restriction two processing.

In addition, even if two process with faces 1,2 butt not each other, by with the foot 70b butt of cylinder space portion 70 set piston body 72, the foot 70b of this cylinder space portion 70 defines the lower limit of the interval width between two processing faces 1,2.That is, the foot 70b of piston body 72 and cylinder space portion 70 processes as suppressing two approaching suppressing portion and playing a role of approaching with faces 1,2, more in other words, processes and separates the mechanism of measuring and play a role by the minimum at the interval between face 1,2 as restriction two.

Like this, limit the maximum and minimum separately amount at above-mentioned interval on one side, the interval z1 that can adjust by the air pressure of said nozzle 73,74 the topmost 70a of cylinder block 72 and cylinder space portion 70 on one side, in other words, adjusts the interval z2 of the foot 70b of cylinder block 72 and cylinder space portion 70.

Nozzle 73,74 can be connected with another pressure source, also can be connected in a pressure source by switching or transferring.

Pressure source can be supply with malleation or supply with any of negative pressure and implement in addition.In the case of the negative pressure source of vacuum etc. is connected with nozzle 73,74, form contrary with above-mentioned action.

Replace other above-mentioned pressure of contact surface imparting mechanism 4 or the part as above-mentioned pressure of contact surface imparting mechanism 4, such cylinder mechanism 7 is set, according to the viscosity of processed liquid, character, carry out the pressure of the pressure source being connected with nozzle 73,74, the setting of interval z1, z2, make the thickness of thin film fluid reach desired value, impose shearing force, realize uniform admixture (being reaction uniformly) under the condition with reaction, can generate fine particle.Particularly, by such cylinder mechanism 7, the pressure of can be cleaning, when steam sterilization etc. carrying out sliding part opens and closes, and can improve the reliability of cleaning, sterilizing.

As shown in Figure 16 (A)～(C), can process and process with forming on face 1 from the central side of the 1st processing portion 10 toward the outer side, the channel form recess 13...13 of extension implement diametrically with the 1st of portion 10 the 1st.In this case, as shown in Figure 16 (A), recess 13...13 can be used as at the 1st processing bending or vortex shape on face 1 and extends to implement, as shown in Figure 16 (B), also can each recess 13 being bent into L font implements, in addition, as shown in Figure 16 (C), recess 13...13 also linearly radiated entends implement.

In addition, as shown in Figure 16 (D), the recess 13 of preferably Figure 16 (A)～(C) is processed and is formed gradient by the mode that the central side of face 1 is deepened gradually and implement to become to the 1st.In addition, the recess 13 of channel form is except can be continuous, and that is also interrupted implements.

By forming such recess 13, there is the effect of the reply increase of output of processed liquid or the minimizing of caloric value, cavitation control, FDB etc.

In the each embodiment shown in above-mentioned Figure 16, although being formed on the 1st, processes with on face 1 recess 13, also can be embodied as and be formed on the 2nd processing with on face 2, and, also can be embodied as and be formed on the 1st and the 2nd processing face 1,2 both sides.

Processing with above-mentioned recess 13, taper are not set on face in the situation that, or, process with a part for face in the case of they are offset to, process the impact that gives processed liquid by the surface roughness of face 1,2 than the above-mentioned recess 13 of formation greatly.Therefore, under these circumstances, if the particle of processed liquid is diminished, just must reduce surface roughness, form smooth face.Particularly, to mix uniformly (reaction) as object in the situation that, process the surface roughness with face for it, realizing uniform admixture (with the reaction uniformly of reaction in the situation that), obtain microgranule as object in the situation that, above-mentioned minute surface, the face that has applied mirror finish are conducive to realize the crystallization of fine monodispersed product.

In the embodiment shown in Figure 12 to Figure 17, for the formation beyond having expressed especially, with Fig. 1 (A) or Figure 11 (C) illustrated embodiment identical.

In addition, in above-mentioned each embodiment, all sealed in housing, but in addition, also can be embodied as, only the inner side of the 1st processing use portion 10 and the 2nd processing use portion 20 is sealed, and its outside is open.That is, until process with face 1 and the 2nd and process with between face 2 by the 1st, stream is sealed, and processed liquid is subject to whole discharge pressures, and still, after passing through, stream is opened, and processed liquid after treatment is not subject to discharge pressure.

In fluid pressure imparting mechanism p1, as pressue device, as mentioned above, preferably implement with compressor, still, as long as can apply authorized pressure to processed liquid always, also can implement by other means.For example, can be by utilizing the deadweight of processed liquid, processed liquid is applied to certain pressure always and implements.

Summarize the blood processor in the respective embodiments described above, it is characterized by, processed liquid is applied to authorized pressure, in the sealed fluid flowing path flowing through at the processed liquid that is subject to this authorized pressure, connect the 1st and process the processing face that can approach separation with face 1 and the 2nd processing with at least 2 of face 2, give two faces 1 for processing that make, 2 approaching pressure of contact surface, by the 1st processing face 1 and the 2nd processing face 2 are relatively rotated, use processed liquid and produce the thin film fluid for sealing in mechanical seal, contrary with mechanical seal (not being for sealing by thin film fluid), this thin film fluid is processed with specially spilling between face 2 from the 1st processing face 1 and the 2nd, on two sides 1, between the processed liquid that 2 become film, realize the processing that mixes (reaction), reclaim.

By so epoch-making method, two processing can be adjusted into 1 μ m to 1mm with the interval of 1,2, face, can be particularly the adjustment of 1～10 μ m.

In the above-described embodiment, in device, form the stream of the fluid being sealed, the fluid pressure imparting mechanism p1 arranging by (the 1st processed liquid) the introduction part side at blood processor, processed liquid is pressurized.

In addition, fluid pressure imparting mechanism p1 that also can be such pressurizes, but is opened to implement by the stream of processed liquid.

Figure 18 to Figure 20 represents an embodiment of such blood processor.Be explained, in this embodiment, as blood processor, example has and has the device of removing liquid from the material of generation, finally only guaranteeing the function of the solid (crystallization) as object.

The simple profilograph that Figure 18 (A) is blood processor, Figure 18 (B) is the expansion profile of its part.Figure 19 be the blood processor shown in Figure 18 have the 1st process the top view of use portion 101.Figure 20 is the simple profilograph that the 1st and the 2nd of above-mentioned blood processor is processed the local major part of use portion 101,102.

Device shown in this Figure 18 to Figure 20, as mentioned above under atmospheric pressure, drops into as the fluid of object of processing, i.e. processed liquid or carry the fluid of the object of such processing.

Be explained, in Figure 18 (B) and Figure 20, for avoiding the numerous and diverse of drawing, the 2nd introduction part d2 omits and is described (also can regard the section that is not provided with the 2nd introduction part d2 position as).

As shown in Figure 18 (A), this fluid treating device possesses mixing arrangement G and drawdown pump Q.This mixing arrangement G possesses: process use portion 101 as the 1st of the member being rotated; Keep the 1st bracket 111 of this processing use portion 101; Process use portion 102 as the 2nd of the member being fixed with respect to housing; Fix the 2nd and process the 2nd bracket 121 of use portion 102; Suppress mechanism 103; Dynamic pressure generating mechanism 104 (Figure 19 (A)); The drive division that the 1st processing use portion 101 and the 1st bracket 111 are together rotated; Cover body 106; Supply with the 1st introduction part d1 of (input) the 1st processed liquid; Discharge the discharge portion 108 of fluid to drawdown pump Q.Omit diagram about drive division.

Above-mentioned the 1st processing is respectively the ring bodies with the shape that hollows out cylindrical center with portion 101 and the 2nd processing portion 102.Two process with portion the 101, the 102nd, are as the member of processing with face 110,120 respectively using two processing with the bottom surface that 101,102, portion is cylinder.

The par that above-mentioned processing has had by mirror ultrafinish with face 110,120.In this embodiment, the 2nd processing is tabular surfaces that whole face has all been implemented mirror ultrafinish with the processing face 120 of portion 102.In addition, although being become with the 2nd, the whole face of the processing face 110 of the 1st processing portion 101 processes the identical tabular surface of use portion 102,, as shown in Figure 19 (A), in tabular surface, there are multiple groove 112...112.This groove 112...112 by the 1st process with the center of cylinder that portion 101 is centered by side, extend radially to the peripheral direction of cylinder.

For the above-mentioned the 1st and the 2nd mirror ultrafinish of processing the processing use face 110,120 of use portion 101,102, preferred surface roughness Ra is 0.01～1.0 μ m.For this mirror ultrafinish more preferably Ra be 0.03～0.3 μ m.

For processing the material of use portion 101,102, employing hard and material that can mirror ultrafinish.This hardness of relevant processing use portion 101,102, is preferably at least Vickers hardness more than 1500.In addition, preferably adopt raw material or the high raw material of conduction of heat that linear expansion coefficient is little.This be due to, process time produce between the part and other parts of heat, if the difference of expansion rate is larger, will deform, thereby affect guaranteeing of appropriate intervals.

As the raw material of above-mentioned processing use portion 101,102, especially preferably adopt following material etc.: SIC is carborundum, it ties up formula hardness is 2000～2500; Surface DLC is the S I C of diamond like carbon coating, and wherein the dimension formula hardness of diamond-like-carbon is 3000～4000; WC is tungsten carbide, and its dimension formula hardness is 1800; Surface has applied WC, the ZrB of DLC coating ₂or the boron system that BTC, B4C are representative is ceramic, dimension formula hardness is 4000～5000.

Though the cover body 106 shown in Figure 18 has omitted the diagram of bottom, but for there being the cylindrical body at the end, top is covered by above-mentioned the 2nd bracket 121.The 2nd bracket 121 is fixed with above-mentioned the 2nd handling part 102 at its lower surface, is provided with up above-mentioned introduction part d1.Introduction part d1 has the hopper 170 for drop into fluid, handled thing from outside.

Though not shown, above-mentioned drive division has the power source of motor etc. and accepts power supply and the axle 50 that rotates from this power source.

As shown in Figure 18 (A), axle 50 is disposed at the inside downward-extension upward of cover body 106.And the upper end of axle 50 is provided with the 1st above-mentioned bracket 111.The 1st bracket 111 is to keep the 1st to process use portion 101, by being arranged on above-mentioned axle 50, makes the 1st processing of processing use portion 101 use the processing face 120 of face 110 and the 2nd processing use portion 102 corresponding.

The 1st bracket 111 is cylinder, and surperficial central authorities are fixed with the 1st and process use portion 101 thereon.The 1st processing becomes one and is fixed with portion 101 and the 1st bracket 111, does not change its position with respect to the 1st bracket 111.

On the other hand, be formed with and accommodate the 2nd and process and accommodate recess 124 with portion 102 in the upper face center of the 2nd bracket 121.

Above-mentioned cross section of accommodating recess 124 and have ring-type.The 2nd processing is housed in columned accommodating in recess 124 with portion 102 in the mode concentric with accommodating recess 124.

This formation of accommodating recess 124 is identical with the embodiment shown in Fig. 1 (A), and (the 1st processes corresponding the 1st annulus 10 of use portion 101, corresponding the 1st bracket 11 of the 1st bracket 111, the 2nd processes corresponding the 2nd bracket 21 of corresponding the 2nd annulus 20, the 2 bracket 121 of use portion 102).

And the 2nd bracket 121 possesses the above-mentioned mechanism 103 of suppressing.Preferably suppress the elastomer that mechanism 103 is used spring etc.Suppress mechanism 103 corresponding with the pressure of contact surface imparting mechanism 4 of Fig. 1 (A), adopt equally and form.That is, suppress mechanism 103 pushing and the 2nd and process the face of face 120 opposition sides for the processing of use portion 102, i.e. bottom surface, the 1st process by portion's 101 sides being positioned at, the 2nd processing below is with suppressing equably each position of portion 102.

On the other hand, the internal diameter of accommodating recess 124 is greater than the 2nd and processes the external diameter of use portion 102, thus, in the time arranging with one heart as mentioned above, process with the outer peripheral face 102b of portion 102 and accommodate between the inner peripheral surface of recess 124 the 2nd, as shown in Figure 18 (B), setting interval t1.

Equally, process with the inner peripheral surface 102a of portion 102 and accommodate between the outer peripheral face of core 22 of recess 124 the 2nd, as shown in Figure 18 (B), setting interval t2.

Above-mentioned interval t1, t2 are respectively used to absorb vibration, eccentric movement, and its size is set as follows, that is, be more than or equal to and can guarantee the size of action and can form sealing.For example, be 100mm to 400mm in the 1st processing with the diameter of portion 101, preferably this interval t1, t2 are respectively 0.05～0.3mm.

The 1st bracket 111 is fixed on axle 50 integratedly, rotation together with axle 50.In addition, though not shown, utilize brake, the 2nd processing can not rotated with respect to the 2nd bracket 121 with portion 102.But, at 110,120, face for two processing, in order to ensure the interval of processing necessary 0.1～10 micron, be the slight gap t shown in Figure 20 (B), as shown in Figure 18 (B), accommodate the bottom surface of recess 124, top and towards the 2nd process use portion 102 top 124a, above between, be provided with interval t3.For this interval t3, together with above-mentioned interval, consider that axle 50 vibrates, extends and sets.

As mentioned above, by the setting of interval t1～t3, the 2nd processes use portion 102, as shown in Figure 18 (B), not only variable on the direction z1 that approaches separation with respect to the 1st processing use portion 101, and processes with the incline direction z2 of face 120 also variable for it.

That is, in this embodiment, suppress mechanism 103 and above-mentioned interval t1～t3 forms relocation mechanism, by this relocation mechanism, at least the 2 process with Bu102 center, tilt can be from several microns to number millimeter variable very in a small amount.Thus, surface vibration, the vibration of use portion 101 are processed in the core vibration, the axle expansion, the 1st that absorb rotating shaft.

Process the above-mentioned groove 112 having with the processing face 110 of portion 101 to the 1st, be described as follows in further detail.The rear end of groove 112 arrives the 1st and processes the inner peripheral surface 101a of use portion 101, and it is that outer peripheral face side is extended that its front end is processed with the outside y of portion 101 towards the 1st.This groove 112 is as shown in Figure 19 (A), and it is that outer peripheral face side reduces gradually with the outside y of portion 101 that its cross-sectional area is processed towards the 1st by Bu101 center x side from the 1st processing of ring-type.

The interval w1 of left and right sides 112a, the 112b of groove 112 is that outer peripheral face side reduces along with processing towards the 1st by Bu101 center x side from the 1st processing with the outside y of portion 101.And the degree of depth w2 of groove 112, as shown in Figure 19 (B), is that outer peripheral face side reduces along with processing towards the 1st by Bu101 center x side from the 1st processing with the outside y of side 101., the end 112c of groove 112 is that outer peripheral face side shoals along with processing towards the 1st by Bu101 center x side from the 1st processing with the outside y of portion 101.

Like this, the width of groove 112 and the degree of depth both along with being that outer peripheral face side reduces gradually towards outside y, thereby its cross-sectional area is reduced gradually towards outside y.And the front end of groove 112 is that y side becomes terminal., the front end of groove 112 is the outer peripheral face 101b that y side does not arrive the 1st processing use portion 101, between the front end and outer peripheral face 101b of groove 112, across outside tabular surface 113.This outside tabular surface 113 is for processing the part with face 110.

In the embodiment shown in this Figure 19, left and right sides 112a, the 112b of such groove 112 and end 112c form stream limiting unit.This stream limiting unit, the 1st is processed groove 112 par around and the par formation dynamic pressure generating mechanism 104 of the 2nd processing use portion 102 of use portion 101.

But also only the wherein either party of the width to groove 112 and the degree of depth adopts above-mentioned formation, reduces sectional area.

Above-mentioned dynamic pressure generating mechanism 104 by processing the fluid of 101,102, use portion through two in the time that the 1st processing is rotated with portion 101, can guarantee desirable slight gap in two processing with 101,102, portion, in the direction that two processing portion 101,102 is separated, produce active force.By the generation of such dynamic pressure, can produce in two processing the slight gap of 0.1～10 μ m with 110,120, face.Such slight gap, though can adjust selection according to the object of processing, still, preferably 1～6 μ m, more preferably 1～2 μ m.In this device, can realize the impossible uniform admixture in the past (reaction uniformly with reaction in the situation that) producing by above-mentioned slight gap and generate microgranule.

Groove 112...112 can implement respectively as follows, that is, and as the crow flies from the y extension toward the outer side of center x side.But, in this embodiment, as shown in Figure 19 (A), process the direction of rotation r of use portion 101 for the 1st, groove 112 center x side in mode in advance of the outside y than groove 112, be positioned at the mode bending in front, groove 112 is extended.

Extend agley by such groove 112...112, can more effectively produce separating force by dynamic pressure generating mechanism 104.

Below, the action of this device is described.

As shown in Figure 18 (A), drop into from hopper 170, the 1st processed liquid R by the 1st introduction part d1 processes the hollow bulb of use portion 102 by the 2nd of ring-type, be subject to the 1st and process the centrifugal force producing with the rotation of portion 101, enter two processing use portions 101, 102, process between the processing face 120 of use portion 102 at the 1st processing face 110 and the 2nd of processing use portion 101 being rotated, mix uniformly (reaction) and according to circumstances carry out the generation of minuteness particle, subsequently, come two processing use portions 101, 102 outside, be expelled to drawdown pump Q side from discharge portion 108 (following, as required the 1st processed liquid R is only called to liquid R).

In above-mentioned, enter into the 2nd liquid R of hollow bulb that processes use portion 102 of ring-type as shown in Figure 20 (A), first, enter the groove 112 of the 1st processing use portion 101 of rotation.On the other hand, though by mirror ultrafinish, process and pass into the gas such as air or nitrogen with face 110,120 and also maintain air-tightness as two of par.So even if rotated produced centrifugal force, liquid R can not former state enter by suppressing between two processing faces 110,120 of mechanism's 103 pressings from groove 112.But liquid R and above-mentioned two sides 112a, 112b, the end 112c of the groove 112 forming as stream limiting unit collide at leisure, produce the dynamic pressure acting in the direction that makes to separate 110,120 separation of two processing face.As shown in Figure 20 (B), thus, liquid R is exuded to tabular surface from groove 112, can guarantee that the slight gap t of 110,120, two processing face is gap.And, such by mirror ultrafinish tabular surface between, mix uniformly the generation of (reaction) and minuteness particle according to circumstances.The bending of above-mentioned groove 112 convection cell effect centrifugal force more reliably, more effectively produces above-mentioned dynamic pressure in addition.

Like this, this fluid treating device by dynamic pressure with suppress the balanced of elastic force pressure that mechanism 103 produces, can between two minute surfaces are processed with face 110,120, guarantee that fine, uniform interval is gap.And by above-mentioned formation, this slight gap can be formed as the ultra tiny interval below 1 μ m.

In addition, by adopting above-mentioned relocation mechanism, processing becomes possibility with the automatic adjustment of the location of 110,120, face, for the physical deformation of the caused each several part of heat because of rotation, generation, the deviation at the interval of each position of processing 110,120, the face of using can be suppressed, the above-mentioned slight gap of this each position can be maintained.

Be explained, in the above-described embodiment, relocation mechanism is the mechanism only arranging on the 2nd bracket 121.In addition, can also replace the 2nd bracket 121, or on the 1st bracket 111, relocation mechanism is also set implement together with the 2nd bracket 121.

Figure 21 to Figure 23 represents above-mentioned groove 112, and other embodiment is shown.

As Figure 21 (A) (B) as shown in, groove 112, as a part for stream limiting unit, can possess smooth wall 112d at front end and implement.And, in the embodiment shown in this Figure 21, in end 112c, between the 1st wall 112d and inner peripheral surface 101a, being provided with step 112e, this step 112e also forms a part for stream limiting unit.

As Figure 22 (A) (B) as shown in, groove 112 can be embodied as, and has the 112f...112f of branch portion of multiple bifurcateds, each 112f of portion has stream limiting unit and implements by dwindling its width.

In the embodiment of Figure 21 and Figure 22, particularly for the structure not illustrating, identical with the embodiment shown in Fig. 1 (A), Figure 11 (C), Figure 18 to Figure 20.

And, in the respective embodiments described above, for the width of groove 112 and one of them side of the degree of depth, from the 1st process use portion 101 inner side toward the outer side, reduce gradually its size, form thus stream limiting unit.In addition, as shown in Figure 23 (A), Figure 23 (B), by not changing width, the degree of depth of groove 112, end face 112f is set in groove 112, the end face 112f of this groove 112 also can form stream limiting unit.As shown in the embodiment that Figure 19, Figure 21 and Figure 22 represent, dynamic pressure produces to be carried out as follows,, width and the degree of depth by groove 112 change as described above, make the end of groove 112, two sides become inclined plane, thus, this inclined plane becomes the compression zone with respect to fluid, produces dynamic pressure.On the other hand, at Figure 23 (A), (B) in illustrated embodiment, the end face of groove 112 becomes the compression zone with respect to fluid, produces dynamic pressure.

In addition, this Figure 23 (A) (B) shown in the situation that, also can make the width of groove 112 and one of them side's of the degree of depth size reduce gradually to implement simultaneously.

Be explained, about the structure of groove 112, be not limited to shown in above-mentioned Figure 19, Figure 21 to Figure 23, the stream limiting unit also can with other shape is implemented.

For example, in structure shown in Figure 19, Figure 21 to Figure 23, groove 112 is not penetrated into the outside of the 1st processing use portion 101.That is, process between the outer peripheral face and groove 112 of use portion 101 the 1st, have outside tabular surface 113.But, be not limited to such embodiment, as long as can produce above-mentioned dynamic pressure, groove 112 also can arrive the 1st processing outer peripheral face side of portion 101 and implement.

For example, process use portion 101 at the 1st shown in Figure 23 (B), shown in dotted line, can be embodied as, the part that makes the area of section be less than other position of groove 112 is formed on the tabular surface 113 of outside.

In addition, as mentioned above, form groove 112 in the mode that reduces gradually laterally sectional area from inner side, make part (terminal) the formation minimum sectional area of the periphery of arrival the 1st processing use portion 101 of groove 112 get final product (not shown).But for effectively producing dynamic pressure, as shown in Figure 19, Figure 21 to Figure 23, preferably groove 112 does not penetrate the 1st and processes the outer peripheral face side of use portion 101.

At this, the various embodiments shown in above-mentioned Figure 18 to Figure 23 are summarized.

This fluid treating device makes the rotating member with smooth processing face have the fixed component of smooth processing face with their smooth processing face mutual subtend with one heart with same, under the rotation of rotating member, supply with by reaction raw materials from the peristome of fixed component on one side, in the fluid treating device of processing on one side, mechanically do not adjust interval between the subtend plane treatment of two members is with face, but booster body is set on rotating member, generation by its its pressure keeps interval, and can form the slight gap of 1～6 μ m that mechanical interval adjustment can not reach, mix (reaction) homogenization and, the ability of the miniaturization of generation particle according to circumstances also significantly improves.

; in this fluid treating device; rotating member and fixed component have smooth processing face at its peripheral part; this smooth processing is with in face; by having the sealing function on face, providing and producing fluidstatic power is that hydrostatic, fluid dynamic power are the fluid treating device of the high-speed rotary of fluid dynamic or aerostatics-aerodynamic power.Above-mentioned power makes to produce between above-mentioned sealing surface small interval, and the fluid treating device with following function can be provided, and, noncontact, machine security, has the function of the homogenization of the mixing (reaction) of height that is.Can form the essential factor of this slight gap, one is the rotating speed of rotating member, and another is the input side and the pressure differential of discharging side of object being treated (fluid).The situation that pressure imparting mechanism is not set in the case of dropping into side under atmospheric pressure drops into object being treated (fluid), due to without pressure differential, must only rely on the rotating speed of rotating member to produce the separation between sealing surface.This is as fluid dynamic power or aerodynamic power and known.

In Figure 18 (A) shown device, though be expressed as the discharge portion that drawdown pump Q is connected to mixing arrangement G, but also can be embodied as like that as previously described, cover body 106 is not set, and drawdown pump Q is not set, but as shown in Figure 24 (A), the tank T using blood processor as decompression use arranges mixing arrangement G in this tank T.

In this case, by the state that makes to be decompressed to vacuum in tank T or to approach vacuum, the object being treated generating in mixing arrangement G nebulizes and is ejected in tank T, encounter by recovery the object being treated that the inwall of tank T flows down, or, reclaim with respect to the above-mentioned object being treated flowing down as gas (steam) separated, the material that is full of tank T internal upper part, can obtain goal object after treatment.

In addition, in the situation that using drawdown pump Q, as shown in Figure 24 (B), mixing arrangement G connects airtight tank T via drawdown pump Q, and in this tank T, object being treated after treatment forms vaporific, can carry out the separation of goal object and extract out.

In addition, as shown in Figure 24 (C), drawdown pump Q is directly connected in tank T, in this tank T, connects the discharge portion of drawdown pump Q and the fluid R except drawdown pump Q, can carry out the separation of goal object.In this case, for gasification portion, liquid R (aqueous portion) is depressurized pump Q and attracts to assemble, and discharges, and do not discharge from gasification portion from discharge portion.

In the respective embodiments described above, show as follows, that is, two kinds of processed liquids of the 1st and the 2nd are imported from the 2nd bracket the 21,121 and the 2nd annulus 20,102 respectively, make it mix (reaction).

Processed liquid being imported to other related embodiment to device below, describes in order.

As shown in Fig. 1 (B), can be embodied as, in the blood processor shown in Fig. 1 (A), the 3rd introduction part d3 is set, the 3rd processed liquid is imported to two and process with 1,2, face, make it similarly mix (reaction) with the 1st processed liquid with the 2nd processed liquid.

The 3rd introduction part d3 is to processing the 3rd fluid mixing with the 1st processed liquid with 1,2 supplies of face.In this embodiment, the 3rd introduction part d3 is provided in a side of the passage of the fluid of the inside of the 2nd annulus 20, and process with face 2 upper sheds the 2nd its one end, and the other end connects the 3rd fluid supply unit p3.

In the 3rd fluid supply unit p3, can adopt compressor, other pump.

The 3rd introduction part d3 processes with compared with the peristome of the peristome on face 2 and the 2nd introduction part d2 the 2nd, is positioned at the 1st outside of processing the center of rotation of use face 1.That is, process with on face 2 the 2nd, the peristome of the 3rd introduction part d3 compared with the opening of the 2nd introduction part d2 in downstream.Between the peristome of the 3rd introduction part d3 and the peristome of the 2nd introduction part d2, spaced apart in the inward-outward direction of the diameter of the 2nd annulus 20.

In this Fig. 1 (B) shown device, formation beyond the 3rd introduction part d3 is also identical with the embodiment shown in Fig. 1 (A), what be explained is, in this Fig. 1 (B) and the Fig. 1 (C) the following describes, Fig. 1 (D), Fig. 2～Figure 11, for avoiding the numerous and diverse of drawing, omit housing 3.Be explained, Fig. 9 (B) (C), Figure 10, Figure 11 (A) (B) in, the part of housing 3 has been described.

In addition, as shown in Fig. 1 (C), can be embodied as, in blood processor shown in Fig. 1 (B), the 4th introduction part d4 is set, the 4th processed liquid is imported to two and process with 1,2, face, make it similarly mix (reaction) with the 1st processed liquid with the 2nd and the 3rd processed liquid.

The 4th introduction part d4 is to processing the 4th processed liquid mixing with the 1st processed liquid with 1,2 supplies of face.In this embodiment, the 4th introduction part d4 is provided in a side of the passage of the fluid of the inside of the 2nd annulus 20, and process with face 2 upper sheds the 2nd its one end, and the other end connects the 4th fluid supply unit p4.

In the 4th fluid supply unit p4, can adopt compressor, other pump.

The 4th introduction part d4 processes the 2nd the outside of using the center of rotation of face 1 with the peristome on face 2 compared with the 3rd introduction part d3 opening in the 1st processing.That is, process with on face 2 the 2nd, the peristome of the 4th introduction part d4 compared with the opening of the 3rd introduction part d3 in downstream.

For the formation beyond the 4th introduction part d4 of Fig. 1 (C) shown device, identical with the embodiment shown in Fig. 1 (B).

And, though not shown, also can be embodied as, 5 above introduction parts such as the 5th introduction part, the 6th introduction part are set in addition, make respectively 5 kinds of above processed liquids mix (reaction).

In addition, as shown in Fig. 1 (D), can be embodied as, in the device of Fig. 1 (A), the 1st introduction part d1 and the 2nd introduction part d2 that are arranged on the 2nd bracket 21 are similarly arranged on to the 2nd processing with on face 2, are arranged on the 2nd bracket 21 to replace.In this case, process with on face 2 the 2nd, the central side that the peristome of the 1st introduction part d1 is also positioned at rotation compared with the 2nd introduction part d2 is upstream side.

In above-mentioned Fig. 1 (D) shown device, be configured in the 2nd of the 2nd annulus 20 together with the peristome of the peristome of the 2nd introduction part d2 and the 3rd introduction part d 3 and process with on face 2.But the peristome of introduction part is not limited to the above-mentioned configuration with respect to processing with face.Particularly, can be as shown in Fig. 2 (A), the peristome of the 2nd introduction part d2 is arranged on the 2nd annulus 20 inner peripheral surface, with the 2nd process and implement with face 2 adjoining positions.In this Fig. 2 (A) shown device, though the peristome of the 3rd introduction part d 3 is similarly configured in the 2nd with Fig. 1 (B) shown device and processes with on face 2, but, also can be by the peristome of the 2nd introduction part d2 being configured in to the above-mentioned the 2nd inner side of processing with face 2, process with on face 2 adjoining positions with the 2nd, thereby the 2nd processed liquid is imported at once and processed with on face.

Like this by the peristome of the 1st introduction part d1 being arranged on the 2nd bracket 21, the peristome of the 2nd introduction part d2 is configured in to the 2nd inner side of processing with face 2, process the face of using 2 adjoining positions (in this case with the 2nd, above-mentioned the 3rd introduction part d3 is set not necessarily), thereby, particularly in the situation that making multiple processed liquid reaction, the processed liquid importing from the 1st introduction part d1 and the processed liquid importing from the 2nd introduction part d2 can be imported to two faces 1 for processing under nonreactive state, 2, and can make both at two faces 1 for processing, between 2, react for the first time.Therefore, above-mentioned formation is particularly suitable for using the situation of reactive high processed liquid.

Be explained, above-mentioned " adjacency " is not limited in following situation, that is, the peristome of the 2nd introduction part d2 is arranged in the mode contacting with the inner side surface of the 2nd annulus 20 as shown in Fig. 2 (A).Distance from the 2nd annulus 20 to the peristome of the 2nd introduction part d2 is following degree,, before multiple processed liquids is imported into 1,2, face of two processing, do not mixed the degree of (reaction) completely, for example, also can be arranged on the position of the 2nd annulus 20 that approaches the 2nd bracket 21.And, also the peristome of the 2nd introduction part d2 can be arranged on to the 1st annulus 10 or the 1st bracket 11 sides.

In addition, in above-mentioned Fig. 1 (B) shown device, between the peristome of the 3rd introduction part d3 and the peristome of the 2nd introduction part d2, inward-outward direction at the diameter of the 2nd annulus 20 is spaced apart, but also can be embodied as, as shown in Fig. 2 (B), above-mentioned interval is not set, the the 2nd and the 3rd processed liquid is imported to two and process with between face 1,2, at once two liquid interflow.According to above-mentioned Fig. 2 of object choice (B) shown device of processing.

In addition, in above-mentioned Fig. 1 (D) shown device, between the opening of the peristome of the 1st introduction part d1 and the 2nd introduction part d2, inward-outward direction at the 2nd annulus 20 diameters has separated interval, but also can be embodied as, this interval is not set, processes with between face 1,2 and the 1st and the 2nd processed liquid is imported to two, make at once two liquid interflow.According to the configuration of the such peristome of the object choice of processing.

In above-mentioned Fig. 1 (B) and Fig. 1 (C) illustrated embodiment, process with on face 2 the 2nd, the peristome of the 3rd introduction part d3 is configured in to the downstream of the peristome of the 2nd introduction part d2, in other words, in the inward-outward direction of the diameter of the 2nd annulus 20, be configured in the outside of the peristome of the 2nd introduction part d2.In addition, as shown in Fig. 2 (C) and Fig. 3 (A), can process with on face 2 the 2nd, the peristome of the 3rd introduction part d3 is disposed to positions different from the 2nd introduction part d2 peristome on the Zhou Fangxiang r0 of the 2nd annulus 20 and implement.In Fig. 3, m1 represents i.e. the 1st peristome of peristome of the 1st introduction part d1, and m2 represents i.e. the 2nd peristome of peristome of the 2nd introduction part d2, and m3 represents i.e. the 3rd peristome of peristome of the 3rd introduction part d3, the inward-outward direction that r1 is circle diameter.

In addition, in the situation that the 1st introduction part d1 is arranged on the 2nd annulus 20, also can, as shown in Fig. 2 (D), process with on face 2 the 2nd, the peristome of the 1st introduction part d1 is disposed in the Zhou Fangxiang of the 2nd annulus 20 position different from the peristome of the 2nd introduction part d2 and is implemented.

In above-mentioned Fig. 3 (A) shown device, use on face 2 in the processing of the 2nd annulus 20, the peristome of 2 introduction parts is configured in the diverse location of Zhou Fangxiang r0, but, also can be embodied as, as shown in Fig. 3 (B), configure the peristome of 3 introduction parts at the diverse location of the Zhou Fangxiang of annulus r0, or as shown in Fig. 3 (C), configure the peristome of 4 introduction parts at the diverse location of the Zhou Fangxiang of annulus r0.Be explained, Fig. 3 (B) (C) in, m4 represents the peristome of the 4th introduction part, in Fig. 3 (C), m5 represents the peristome of the 5th introduction part.And, though not shown, also can be embodied as, configure the peristome of more than 5 introduction parts at the diverse location of the Zhou Fangxiang of annulus r0.

In above-mentioned shown device, the 2nd introduction part to the 5 introduction parts can import respectively different processed liquids, i.e. the 2nd, the 3rd, the 4th, the 5th processed liquid.On the other hand, can be embodied as, from peristome m2～m5 of the 2nd～5th, by all similar, the 2nd processed liquid imports and processes with between face.Though not shown, in this case, can be embodied as, the 2nd introduction part to the 5 introduction parts are in annulus internal communication, and are connected to a fluid supply unit, i.e. the 2nd fluid supply unit p2.

In addition, can be by combination with the enforcement of getting off, that is, the peristome of multiple introduction parts is set and the diverse location that is the inward-outward direction r1 of diameter in circle diameter direction arranges the peristome of multiple introduction parts at the diverse location of the Zhou Fangxiang of annulus r0.

For example, as shown in Fig. 3 (D), process with the peristome m2～m9 that is provided with 8 introduction parts on face 2 the 2nd, 4 m2～m5 are wherein arranged on the diverse location of Zhou Fangxiang r0 of annulus and the same position setting on diametric(al) r1, and other 4 m6～m9 are arranged on the diverse location of Zhou Fangxiang r0 of annulus and the same position on diametric(al) r1.And this other peristome m6～m9 is configured in the diametric outside of above-mentioned 4 peristome m2～m5 on diametric(al) r1.And, though the position identical with the peristome of inner side on the Zhou Fangxiang r0 that the peristome in this outside can be arranged at respectively at annulus, still, consider the rotation of annulus, also can be embodied as, as shown in Fig. 3 (D), be arranged on the diverse location of the Zhou Fangxiang r0 of annulus.In addition, in this case, peristome can be configuration, the quantity shown in Fig. 3 (D).

For example, as shown in Fig. 3 (E), also the peristome in footpath direction outside can be configured in to polygonal vertex position, i.e. tetragonal vertex position in this situation, is configured in the peristome of diametric(al) inner side on this polygonal limit.Certainly, also can adopt other configuration.

In addition, peristome beyond the 1st peristome m1 all imports the 2nd processed liquid and processes between the face of using, may be embodied as, each this peristome that imports the 2nd processed liquid is not to scatter on the Zhou Fangxiang r0 processing with face, but as shown in Fig. 3 (F), on Zhou Fangxiang r0, form continuous peristome.

What be explained is, according to the object of processing, as shown in Fig. 4 (A), can be embodied as, in Fig. 1 (A) shown device, will be arranged on the 2nd introduction part d2 on the 2nd annulus 20 and the 1st introduction part d1 and be similarly arranged on the middle body 22 of the 2nd bracket 21.In this case, with respect to the peristome of the 1st introduction part d1 that is positioned at the 2nd annulus 20 center, the opening of the 2nd introduction part d2 is in its outside, and spaced apart.And, as shown in Fig. 4 (B), can be embodied as, in Fig. 4 (A) shown device, the 3rd introduction part d3 is arranged to the 2nd annulus 20.As shown in Fig. 4 (C), can be embodied as, in Fig. 4 (A) shown device, interval is not set between the peristome of the peristome of the 1st introduction part d1 and the 2nd introduction part d2, the the 1st and the 2nd processed liquid is imported behind the space of the 2nd annulus 20 inner sides, at once two liquid interflow.In addition, according to the object of processing, can be embodied as, as shown in Fig. 4 (D), in Fig. 4 (A) shown device, identical with the 2nd introduction part d2, the 3rd introduction part d3 is also arranged on the 2nd bracket 21.Though not shown, still, also can be embodied as, on the 2nd bracket 21, more than 4 introduction parts is set.

And, according to the object of processing, as shown in Fig. 5 (A), can be embodied as, in the device shown in Fig. 4 (D), the 4th introduction part d4 is set on the 2nd annulus 20, the 4th processed liquid is imported to two and process with between face 1,2.

As shown in Fig. 5 (B), can be embodied as, in Fig. 1 (A) shown device, the 2nd introduction part d2 is arranged to the 1st annulus 10, process with the peristome on face 1 with the 2nd introduction part d2 the 1st.

As shown in Fig. 5 (C), can be embodied as, in Fig. 5 (B) shown device, the 1st annulus 10 is provided with the 3rd introduction part d3, process with on face 1 the 1st, the peristome of the 3rd introduction part d3 is configured in and the peristome of the 2nd introduction part d2 different position on the Zhou Fangxiang of the 1st annulus 10.

As shown in Fig. 5 (D), can be embodied as, in Fig. 5 (B) shown device, be substituted in the 1st introduction part d1 is set on the 2nd bracket 21, the 1st introduction part d1 is set on the 2nd annulus 20, processes with the peristome that configures the 1st introduction part d1 on face 2 the 2nd.In this case, two peristomes of the 1st and the 2nd introduction part d1, d2 are configured in same position in the inward-outward direction of circle diameter.

In addition, as shown in Fig. 6 (A), also can be embodied as, in Fig. 1 (A) shown device, the peristome that the 3rd introduction part d3 is arranged at the 1st annulus 10, the 3 introduction part d3 is arranged on the 1st processing with on face 1.In this case, two peristomes of the 2nd and the 3rd introduction part d2, d3 are configured in same position in the inward-outward direction of circle diameter.But, also above-mentioned two peristomes can be disposed to different positions in the inward-outward direction of the diameter of annulus.

In Fig. 5 (C) shown device, although two peristomes of the 2nd and the 3rd introduction part d2, d3 are arranged on to identical position in the inward-outward direction of the diameter of the 1st annulus 10, be in direction of rotation, to be arranged on different positions at the Zhou Fangxiang of the 1st annulus 10 simultaneously, but, also can be embodied as, in this device, as shown in Fig. 6 (B), two peristomes of the 2nd and the 3rd introduction part d2, d3 are arranged on to identical position, simultaneously in the inward-outward direction of the diameter of the 1st annulus 10, are arranged on different positions on the Zhou Fangxiang of the 1st annulus 10.In this case, can be embodied as, as shown in Fig. 6 (B), between two peristomes of the 2nd and the 3rd introduction part d2, d3, spaced apart in the inward-outward direction of the diameter of the 1st annulus 10, in addition, though not shown, also can be embodied as, not separate this interval, make at once the 2nd processed liquid and the 3rd processed liquid interflow.

In addition, can be embodied as, as shown in Fig. 6 (C), be substituted in the 1st introduction part d1 is set on the 2nd bracket 21, but together with the 2nd introduction part d2, the 1st introduction part d1 is arranged on the 1st annulus 10.In this case, process with in face 1 the 1st, the peristome of the 1st introduction part d1 is arranged on the upstream side (inner side of the inward-outward direction of the diameter of the 1st annulus 10) of the peristome of the 2nd introduction part d2.Between the peristome of the 1st introduction part d1 and the peristome of the 2nd introduction part d2, spaced apart in the inward-outward direction of the diameter of the 1st annulus 10.But, though not shown, also can not separate this compartment of terrain and implement.

In addition, can be embodied as, as shown in Fig. 6 (D), process with in face 1 at the 1st of Fig. 6 (C) shown device, at the diverse location of the Zhou Fangxiang of the 1st annulus 10, configure respectively the peristome of the 1st introduction part d1 and the 2nd introduction part d2.

In addition, though not shown, at Fig. 6 (C) in the embodiment shown in (D), can be embodied as, on the 1st annulus 10, more than 3 introduction parts is set, at the 2nd diverse location of processing with the Zhou Fangxiang on face 2, or, at the diverse location of the inward-outward direction of circle diameter, configure each peristome.For example, also can process with adopting the 2nd configuration of processing with peristome shown in Fig. 3 adopting in face 2 (B)～Fig. 3 (F) in face 1 the 1st.

As shown in Fig. 7 (A), can be embodied as, in Fig. 1 (A) shown device, be substituted on the 2nd annulus 20 the 2nd introduction part d2 is set, the 2nd introduction part is set on the 1st bracket 11.In this case, in the position being surrounded by the 1st annulus 10 above the 1st bracket 11, preferably at the peristome of center configuration the 2nd introduction part d2 of the central shaft of the rotation of the 1st annulus 10.

As shown in Fig. 7 (B), in the embodiment shown in Fig. 7 (A), the 3rd introduction part d 3 can be arranged to the 2nd annulus 20, the peristome of the 3rd introduction part d 3 is configured in to the 2nd and processes with on face 2.

In addition, as shown in Fig. 7 (C), can be embodied as, be substituted on the 2nd bracket 21 the 1st introduction part d1 is set, the 1st introduction part d1 is set on the 1st bracket 11.In this case, in the position being surrounded by the 1st annulus 10 above the 1st bracket 11, preferably on the central shaft of the rotation of the 1st annulus 10, configure the peristome of the 1st introduction part d1.In addition, in this case, as shown in the figure, the 2nd introduction part d2 can be arranged to the 1st annulus 10, its peristome be configured in to the 1st and process with on face 1.In addition, though not shown, in this case, can the 2nd introduction part d2 is arranged to the 2nd annulus 20, process with configuring its peristome on face 2 the 2nd.

And, as shown in Fig. 7 (D), can be embodied as, the 2nd introduction part d2 shown in Fig. 7 (C) is arranged on the 1st bracket 11 together with the 1st introduction part d1.In this case, in the position being surrounded by the 1st annulus 10 above the 1st bracket 11, the peristome of configuration the 2nd introduction part d2.In addition, in this case, in Fig. 7 (C), also can be using the 2nd introduction part d2 arranging on the 2nd annulus 20 as the 3rd introduction part d3.

In the each embodiment shown in above-mentioned Fig. 1～Fig. 7, the 1st bracket 11 and the 1st annulus 10 rotate with respect to the 2nd bracket 21 and the 2nd annulus 20.In addition, as shown in Fig. 8 (A), can be embodied as, in Fig. 1 (A) shown device, on the 2nd bracket 21, arrange and be subject to the rotating shaft 51 that rotates from the revolving force of rotary driving part, the 2nd bracket 21 is rotated up in the side contrary with the 1st bracket 11.For the rotary driving part of rotating shaft 51, also can divide and be arranged with the device that the rotating shaft 50 of the 1st bracket 11 is rotated, or implement as following,, by power transfer means such as gears, be subject to power from the drive division that the rotating shaft 50 of the 1st bracket 11 is rotated.In this case, the 2nd bracket 21 forms with above-mentioned housing split ground, and is similarly rotatably housed in this housing with the 1st bracket 11.

And, as shown in Fig. 8 (B), can be embodied as, in Fig. 8 (A) shown device, same with the device of Fig. 7 (B), the 2nd introduction part d2 is set on the 1st bracket 11, to be substituted in, the 2nd introduction part d2 is set on the 2nd annulus 20.

In addition, though not shown, also can be embodied as, in Fig. 8 (B) shown device, the 2nd introduction part d2 is set on the 2nd bracket 21, to be substituted in, the 2nd introduction part d2 is set on the 1st bracket 11.In this case, the 2nd introduction part d2 is identical with the device of Fig. 4 (A).As shown in Fig. 8 (C), also can be embodied as, in Fig. 8 (B) shown device, the 3rd introduction part d3 is set on the 2nd annulus 20, the peristome of this introduction part d3 is arranged on to the 2nd and processes with on face 2.

And, as shown in Fig. 8 (D), also can be embodied as, do not make the 1st bracket 11 rotate, only rotate the 2nd bracket 21.Though not shown, also can be embodied as, in the device shown in Fig. 1 (B)～Fig. 7, the 2nd bracket 21 and the 1st bracket 11 all rotate, or only the 2nd bracket 21 rotates separately.

As shown in Fig. 9 (A), the 2nd to process use portion 20 be annulus, and the 1st processing is not annulus with portion 10, but same with other the 1st bracket 11 of embodiment, directly there is the member that rotating shaft 50 conducts are rotated.In this case, the 1st upper surface of processing use portion 10 is processed and used face 1 as the 1st, this processing is not ring-type with face, does not possess hollow space, forms the same tabular surface.And in Fig. 9 (A) shown device, same with the device of Fig. 1 (A), the 2nd annulus 20 is provided with the 2nd introduction part d2, its peristome is configured in the 2nd and processes with on face 2.

As shown in Fig. 9 (B), can be embodied as, in Fig. 9 (A) shown device, the 2nd bracket 21 is independent with housing 3, between housing 3 and the 2nd bracket 21, pressure of contact surface imparting mechanism 4 is set, and this pressure of contact surface imparting mechanism 4 is to make the 2nd bracket 21 the 1st process elastomers that use portion 10 approaches separation etc. to what be provided with the 2nd annulus 20.In this case, as shown in Fig. 9 (C), the 2nd processing does not form annulus with portion 20, as the member that is equivalent to above-mentioned the 2nd bracket 21, the lower surface of this member can be formed with face 2 as the 2nd processing.And, as shown in Figure 10 (A), can be embodied as, in Fig. 9 (C) shown device, the 1st processing does not form annulus with portion 10 yet, and (B) shown device is the same with Fig. 9 (A), in other embodiment, using the position that is equivalent to the 1st bracket 11 as the 1st processing use portion 10, its upper surface is processed with face 1 as the 1st.

In the respective embodiments described above, the at least the 1 processed liquid is to process use portion 10 and the 2nd from the 1st to process the central part supply that use portion 20 is the 1st annulus 10 and the 2nd annulus 20, by the processing that utilizes other processed liquid to carry out, mix after (reaction), be discharged to the outside of the inward-outward direction of its diameter.

In addition, as shown in Figure 10 (B), also can be embodied as, supply with the 1st processed liquid towards inner side from the outside of the 1st annulus 10 and the 2nd annulus 20.In this case, as shown in the figure, with the outside of airtight the 1st bracket 11 of housing 3 and the 2nd bracket 21, the 1st introduction part d1 is directly arranged to this housing 3, in the inner side of housing, the peristome of this introduction part is configured in the position corresponding with the docking location of two annulus 10,20.And, in the device of Fig. 1 (A), in the position that is provided with the 1st introduction part d1, become the position at the 1st annulus 10 center in the 1st bracket 11, be provided with discharge portion 36.In addition, clip the central shaft of the rotation of bracket, configure the peristome of the 2nd introduction part d2 in the opposition side of this peristome of housing.But, the peristome of the 2nd introduction part d2 is identical with the peristome of the 1st introduction part d1, as long as the inner side at housing and be configured in the position corresponding with the docking location of two annulus 10,20, and be not defined as the opposition side of the peristome that is formed on the 1st introduction part d1 as described above.

In this case, the outside of the diameter of two annulus 10,20 becomes upstream, and the inner side of two annulus 10,20 becomes downstream.

Like this, the movement of carrying out processed liquid at outside-in, as shown in Figure 16 (E), can process the 1st of use portion 10 the 1st and process with in face 1, implement with the channel form recess 13...13 that the lateral central side of portion 10 extends from the 1st processing.By forming such recess 13...13, for above-mentioned balance K, be preferably formed more than 100% unequilibrated type.Its result, when rotated, in the recess 13...13 of above-mentioned channel form, produce dynamic pressure, two processing can be rotated reliably non-contactly with face 1,2, the danger of the abrasion that produced by contact etc. disappears, in the embodiment as shown in Figure 16 (E), the separating force being produced by the pressure of processing fluid, produces at the inner 13a place of recess 13.

As shown in Figure 10 (C), can be embodied as, in Figure 10 (B) shown device, by being arranged at the 2nd introduction part d2 of sidepiece of housing 3, change this position, be arranged on the 1st annulus 10, its peristome is configured in to the 1st and processes with on face 1.In this case, as shown in Figure 10 (D), can be embodied as, the 1st processes use portion 10 not as annulus formation, identical with Fig. 9 (A), Fig. 9 (B), Figure 10 (A) shown device, in other embodiment, using the position that is equivalent to the 1st bracket 11 as the 1st processing use portion 10, using its upper surface as the 1st face 1 for processing, and, the 2nd introduction part d2 is arranged to the 1st and processes in use portion 10, its peristome is arranged on to the 1st and processes with on face 1.

As shown in Figure 11 (A), can be embodied as, in the device shown in Figure 10 (D), the 2nd processes use portion 20 does not form as annulus, in other embodiment, using the member that is equivalent to the 2nd bracket 21 as the 2nd processing use portion 20, its lower surface is processed with face 2 as the 2nd.And, may be embodied as, using the 2nd process use portion 20 as with independently member of housing 3, housing 3 and the 2nd processing use portion 20 between, with Fig. 9 (B) (C), Figure 10 (A) shown device is identical, is provided with pressure of contact surface imparting mechanism 4.

In addition, as shown in Figure 11 (B), also can be embodied as, using the 2nd introduction part d2 of Figure 11 (A) shown device as the 3rd introduction part d 3, the 2nd introduction part d2 is set in addition.In this case, process with in face 2 the 2nd, the peristome of the peristome of the 2nd introduction part d2 being compared to the 3rd introduction part d 3 is configured in downstream.

Each device shown in above-mentioned Fig. 4, Fig. 5 (A), Fig. 7 (A) (B) (D), Fig. 8 (B) (C) shown device be other processed liquid arrive process with before between face 1,2 with the device at the 1st processed liquid interflow, the reaction of be not suitable for crystallization, separating out material fast.But the material slow for response speed can adopt such device.

About the fluid treating device that is applicable to the related method working of an invention of the application, be summarized as follows.

As mentioned above, this fluid treating device has: fluid pressure imparting mechanism, and this fluid pressure imparting mechanism is given authorized pressure to processed liquid; The 1st processes at least 2 processing use portions of use portion 10 and the 2nd processing use portion 20, the 1st processes in the sealed fluid flowing path that is arranged on portion 10 that the processed liquid of this authorized pressure flows through, and the 2nd processing use portion 20 can relatively approach separation with respect to the 1st handling part 10; The 1st processes and processes with at least 2 processing faces of face 2 with face 1 and the 2nd, and the 1st processes and process the setting by least 2 processing face of face 2 mutual subtend in above-mentioned processing use portion 10,20 with face 1 and the 2nd; Rotary drive mechanism, this rotary drive mechanism relatively rotates the 1st processing use portion 10 and the 2nd processing use portion 20; With between face 1,2, carry out the processing (processing of also reacting) of the mixing of at least 2 kinds of processed liquids in two processing with reaction in the situation that.There is compression face in the 1st processing with portion 10 and the 2nd processing portion 20 of processing at least the 2 in portion 20, and at least a portion of this compression face is made up of with face 2 the 2nd processing, compression face is subject to fluid pressure imparting mechanism gives at least one party's of processed liquid pressure, is created in the 2nd and processes and process from the 1st the power moving it by the direction that face 1 separates with face 2.And, in this device, can approach between the 1st processing face 1 and the 2nd processing face 2 separating and relatively rotate, pass into the processed liquid that is subject to above-mentioned pressure, thus, each processed liquid forms the thin film fluid of specific thickness while passes through two and process with 1,2, face, thereby, between this processed liquid, produce desirable admixture (reaction).

In addition, in this fluid treating device, preferably adopt the device that possesses buffer gear, this buffer gear is adjusted the 1st and is processed with face 1 and the 2nd micro-vibration, the location of processing with at least one party of face 2.

In addition, in this fluid treating device, preferably adopt and possess shift adjusting machine, this shift adjusting machine adjustment the 1st is processed with axial displacement one or both of face 1 and the 2nd processing face 2, that caused by abrasion etc., can maintain the thickness of the thin film fluid of 1,2, two processing face.

And, in this fluid treating device, as above-mentioned fluid pressure imparting mechanism, can adopt the pressue device that processed liquid is applied to certain compressor of sending into pressure etc.

Be explained, this is because above-mentioned pressue device adopts the device of the adjustment of the increase and decrease of sending into pressure.This pressue device needs the pressure of setting to be kept to certain, but as adjusting the parameter of processing with the interval between face, is also necessary to adjust.

In addition, in this fluid treating device, can adopt and have the structure that separates suppressing portion, this separation suppressing portion specifies the largest interval between the 1st above-mentioned processing face 1 and the 2nd processing face 2, suppresses the separation of two more than largest interval processing faces 1,2.

And in addition, in this fluid treating device, can adopt the structure with the suppressing portion of approaching, and this approaches suppressing portion and specifies that the above-mentioned the 1st processes the minimum interval of using between face 1 and the 2nd processing face 2, and two below inhibition minimum interval processed and used the approaching of face 1,2.

And, in this fluid treating device, can adopt following structure, that is, the 1st processing is processed with face 2 both sides towards the anti-direction rotation of mutual idea with face 1 and the 2nd.

In addition, in this fluid treating device, can adopt the structure of the big envelope with temperature adjustment use, the big envelope of this temperature adjustment use is adjusted the above-mentioned the 1st and is processed by face 1 and the 2nd temperature of processing by one or both of face 2.

Further in addition, in this fluid treating device, preferably adopt following structure, that is, the above-mentioned the 1st processes and has carried out mirror finish by one or both at least a portion of face 1 and the 2nd processing face 2.

In this fluid treating device, can adopt following structure, that is, the above-mentioned the 1st one or both that process with face 1 and the 2nd processing face 2 has recess.

And, in this fluid treating device, preferably adopt following structure,, as the supply mean that mixes the opposing party's of (reaction) processed liquid in the processed liquid to a side, there is the other importing road of the passage of the processed liquid that is independent of a side, process with face 1 and the 2nd and process and use at least either party of face 2 the above-mentioned the 1st, there is the peristome communicating with above-mentioned other importing road, the opposing party's who carries processed liquid can be imported to the processed liquid of one side from this other importing road.

In addition, as the fluid treating device of implementing the present application, can adopt as follows: have fluid pressure imparting mechanism, this fluid pressure imparting mechanism is to the additional authorized pressure of processed liquid, the 1st processes with face 1 and the 2nd and processes and can relatively approach the processing faces that separate with at least 2 of face 2, and the 1st processing is flow through with the processed liquid of this authorized pressure with face 2 with face 1 and the 2nd processing, and sealed fluid flowing path is connected, pressure of contact surface imparting mechanism, this pressure of contact surface imparting mechanism is given pressure of contact surface to two processing with 1,2, face, rotary drive mechanism, this rotary drive mechanism rotates the 1st processing face 1 and the 2nd processing face 2 relatively, thus, at two faces 1 for processing, 2, carrying out the mixing (reaction) of the processed liquid of at least 2 kinds processes, the 1st processing face 1 and the 2nd being relatively rotated in being endowed pressure of contact surface is processed with between face 2, pass into the processed liquid of at least one of having given pressure from fluid pressure imparting mechanism, and, by passing into another kind of processed liquid, the above-mentioned a kind of processed liquid that has been endowed pressure from fluid pressure imparting mechanism forms the thin film fluid of specific thickness on one side, process with face 1 by two on one side, 2, now, the processed liquid of this another kind is mixed, between processed liquid, there is desirable admixture (reaction).

This pressure of contact surface imparting mechanism can form the micro-vibration of adjustment in said apparatus, buffer gear or the shift adjusting machine of location implemented.

And then, as the fluid treating device of implementing the present application, can adopt with lower device,, this device has: the 1st introduction part, and the processed liquid of at least one party in 2 kinds of processed liquids of mixed (reaction) is imported this device by the 1st introduction part, fluid pressure imparting mechanism p, this fluid pressure imparting mechanism p is connected in the 1st introduction part and gives pressure to this side's processed liquid, the 2nd introduction part, the processed liquid of at least other side in 2 kinds of processed liquids of mixed (reaction) is imported this device by the 2nd introduction part, at least 2 processing use portions, these at least 2 processing are that the 1st of the sealed fluid flowing path that is arranged at that this side's processed liquid flows through is processed use portion 10 and processes and can relatively approach the 2nd processing use portion 20 separating with portion 10 with respect to the 1st with portion, face 1 and the 2nd at least 2 processing faces processing with face 2 for the 1st processing, the 1st processing is processed with the position that is arranged on mutual subtend in portion 10,20 at these with face 1 and the 2nd processing face 2, bracket 21, this bracket 21 is accommodated the 2nd with the 2nd processing by the mode that face 2 exposes and is processed use portion 20, rotary drive mechanism, this rotary drive mechanism is relatively rotated the 1st processing portion 10 and the 2nd processing portion 20, pressure of contact surface imparting mechanism 4, this pressure of contact surface imparting mechanism 4 pushes the 2nd and processes use portion 20, and the 2nd processing face 2 is processed with face 1 in crimping or approaching state with respect to the 1st, at two faces 1 for processing, 2, the mixing (reaction) of carrying out between processed liquid is processed, above-mentioned bracket 21 is movable bodys not, to make in thering is the peristome of above-mentioned the 1st introduction part, to processing with face 1, the interval of 2 affects, the 1st processes the peristome with at least one party of portion 10 and the 2nd introduction part 20 with above-mentioned the 2nd introduction part, the 2nd processing use portion 20 is ring bodies, the 2nd processing is slided with respect to bracket 21 with face 2, approach and separate with face 1 with the 1st processing, the 2nd processing has compression face with portion 20, compression face is subject to the effect that fluid pressure imparting mechanism p gives the pressure of processed liquid, make the 2nd to process and process from the 1st the direction separating with face 1 with face 2 and produce the power moving it, at least a portion of above-mentioned compression face is made up of with face 2 the 2nd processing, can approach between separation and counterrotating the 1st processing face 1 and the 2nd processing face 2, the processed liquid that has been endowed a side of pressure passes into, simultaneously, by an other side's processed liquid being supplied to two faces 1 for processing, 2, two processed liquids form the thin film fluid of specific thickness while pass through two and process with face 1, 2, processed liquid in passing through is mixed, promote thus the desirable mixing (reaction) between processed liquid, the fluid pressure of giving by pressure of contact surface and the fluid pressure imparting mechanism p1 of pressure of contact surface imparting mechanism 4 make two faces 1 for processing, the equilibrium of the power of 2 separation, at two faces 1 for processing, 2 keep the slight gap of the thin film fluid that produces above-mentioned specific thickness.

This fluid treating device also can be embodied as, the 2nd introduction part also be connected in the 1st introduction part the same be connected in other fluid pressure imparting mechanism, thereby pressurized.And, also can be embodied as, the processed liquid importing from the 2nd introduction part is not pressurizeed by other fluid pressure imparting mechanism, but the vacuum suction being produced in the 2nd introduction part be supplied to two processing with between faces 1,2, above-mentioned negative pressure is that the fluid pressure of the processed liquid that imported by the 1st introduction part produces.And, also can be embodied as, this opposing party's processed liquid is mobile by its deadweight in the 2nd introduction part, flows to below from top, processes with between face 1,2 thereby be supplied to.

As mentioned above, be not limited only to the peristome of the 1st introduction part to be arranged on the 2nd bracket, also this peristome of the 1st introduction part can be arranged on the 1st bracket, the peristome of above-mentioned the 1st introduction part become a side processed liquid to device in supply port.In addition, also can be embodied as, this peristome of the 1st introduction part is formed on at least one party of two processing face.But, in following situation,, according to reaction, be necessary to supply with and must first import situation about processing with the processed liquid between face 1,2 from the 1st introduction part, which processing face no matter the peristome of the 2nd introduction part of the supply port in the device of formation the opposing party's processed liquid be positioned at, and the peristome of comparing above-mentioned the 1st introduction part all must be configured in the position in downstream.

And, as the fluid treating device for implementing the present application, can adopt following device.

This fluid treating device has: multiple introduction parts, and the plurality of introduction part imports respectively the of more than two kinds processed liquid of mixing (reaction), fluid pressure imparting mechanism p, this fluid pressure imparting mechanism is given pressure at least one of this processed liquid of more than two kinds, at least 2 processing use portions, these at least 2 processing with portion be arranged on the 1st in the sealed fluid flowing path that this processed liquid flows process with portion 10 with can process and relatively approach the 2nd processing use portion 20 separating with portion 10 with respect to the 1st, the 1st processes at least 2 processing face 1,2, the 1 of using face 1 and the 2nd processing to use face 2 processes the position that is arranged on mutual subtend in these processing use portions 10,20 with face 1 and the 2nd processing face 2, rotary drive mechanism, this rotary drive mechanism makes the 1st to process use portion 10 and the relative rotation of the 2nd processing use portion 20, at two faces 1 for processing, 2, the mixing (reaction) of carrying out between processed liquid is processed, processing use portion 10 and the 2nd the 1st processes in use portion 20, the at least the 2 processing has compression face with portion 20, and, at least a portion of this compression face is made up of with face 2 the 2nd processing, compression face is subject to fluid pressure imparting mechanism gives the pressure of processed liquid, make the 2nd processing face 2 produce from the 1st processing face 1 detaching direction the power moving it, and, the 2nd process with portion 20 have towards with the 2nd approaching use adjustment face 24 of processing with face 2 opposition sides, approach and be subject to being applied to the authorized pressure on processed liquid with adjustment face 24, make the 2nd to process the power moving it with generation in the approaching direction of face 1 to the 1st processing with face 2, by the above-mentioned approaching Area Ratio by the projected area that approaches detaching direction of adjustment face 24 and the projected area that approaches detaching direction of above-mentioned compression face, the 2nd processing face 2 that determines processes with respect to the 1st the power moving to detaching direction with face 1, this masterpiece is making a concerted effort of the total pressure suffered from processed liquid, the processed liquid that has been endowed pressure passes into and can approach between the 1st processing face 1 and the 2nd processing face 2 that separates and be relatively rotated, in this processed liquid other the processed liquid of mixed (reaction) in two processing with mixed between faces, mixed processed liquid forms the thin film fluid of specific thickness while passes through two and process with face 1, 2, obtain desirable product processing with in passing through between face.

In addition, the processing method of the present application is summarized as follows.This fluid treatment method is for giving the 1st processed liquid authorized pressure, process with face 1 and the 2nd and process and be connected in the sealed fluid flowing path that is subject to that the processed liquid of this authorized pressure flows through with the processing face that at least 2 of face 2 can approach separation relatively the 1st, give two faces 1 for processing that make, 2 approaching pressure of contact surface, the 1st processing face 1 and the 2nd is processed uses face 2 relatively to rotate, and processed liquid is imported to this face 1 for processing, 2, by the stream except above-mentioned, the 2nd processed liquid that will mix with this processed liquid (reaction) imports above-mentioned face 1 for processing, 2, make two processed liquids mix (reaction), give the afore mentioned rules pressure of the 1st processed liquid to major general as making two faces 1 for processing, 2 separating forces that separate, this separating force and above-mentioned pressure of contact surface are situated between by processing with face 1, the processed liquid of 2 and equilibrium, thus at two faces 1 for processing, 2 maintain the slight gap of regulation, processed liquid is processed with face 1 by two as the thin film fluid of the thickness of regulation, 2, this by carry out equably the mixing (reaction) of two processed liquids, with evolution reaction in the situation that, crystallizable, separate out desirable product.

Below, other embodiment of the present application is described.Figure 25 is that the processing that is rotated with respect to the opposing party at least one party that can approach separation is processed the simplification profile of fluid treating device to object being treated between with face.(A) of Figure 26 is the 1st simplification top view of processing with face of Figure 25 shown device, is (B) enlarged drawing of the major part of the processing face of Figure 25 shown device.(A) of Figure 27 is the profile on the 2nd importing road, is (B) for illustrating that the 2nd imports the enlarged drawing of the major part of the processing face on road.

In Figure 25, U represents top, and S represents below.In Figure 26 (A), Figure 27 (B), R represents direction of rotation.In Figure 27 (B), C represents the direction (radial direction) of centrifugal force.

This device, as the above-mentioned processed liquid having illustrated, use at least 2 kinds of fluids, wherein at least one fluid contains at least one object being treated, in the mutual subtend that can approach separation, processing that arrange, that at least one party is rotated with respect to the opposing party is with between face, make above-mentioned each fluid interflow and form thin film fluid, in this thin film fluid, above-mentioned object being treated is carried out to processing reaction.Be explained, above-mentioned " processing ", does not limit the form of giving object being treated reaction, comprises yet and only mixes the form of disperseing without reaction.

As shown in figure 25, this device has: the 2nd bracket 21, fluid pressure imparting mechanism P and the pressure of contact surface imparting mechanism of the 1st bracket 11, configuration above the 1st bracket 11.Pressure of contact surface imparting mechanism is made up of spring 43 and air introduction part 44.

On the 1st bracket 11, be provided with the 1st and process use portion 10 and rotating shaft 50.The 1st to process with portion 10 be to be called the ring bodies that coordinates ring, and what had by mirror finish the 1st processes the face 1 used.Rotating shaft 50 is fixed on the 1st bracket 11 center with the fixture 81 of bolt etc., its rear end is connected with the rotating driving device 82 (rotary drive mechanism) of motor etc., and the driving force of rotating driving device 82 is passed to the 1st bracket 11 and the 1st bracket 11 is rotated.The 1st processing becomes one and is rotated with above-mentioned the 1st bracket 11 with portion 10.

On the top of the 1st bracket 11, be provided with the resettlement section that can accommodate the 1st processing use portion 10, by embedding in this resettlement section, the 1st processing is arranged on the 1st bracket 11 with portion 10.And the 1st processes use portion 10 fixes by spline pin 83, do not rotate with respect to the 1st bracket 11 making.But, also can replace spline pin 83, do not rotate making so that the methods such as shrink fit are fixing.

Above-mentioned the 1st processing is exposed from the 1st bracket 11 with face 1, towards the 2nd bracket 21.The 1st processes and pottery, sintering metal, abrasion performance steel, other metal has been implemented the material of cured, hard material is carried out liner, coating, carried out the material of plating etc. with the material employing of face.

On the 2nd bracket 21, be provided with: the 2nd processes use portion 20; Import the 1st introduction part d1 of fluid from processing use portion inner side; As the spring 43 of above-mentioned pressure of contact surface imparting mechanism; With air introduction part 44.

The 2nd processing is the ring bodies that are called compression ring with portion 20, what had by mirror finish the 2nd processes with face 2 and compression face 23 (be called below and separate with adjustment face 23), this compression face 23 be positioned at the 2nd process with the inner side of face 2 and with the 2nd process the face of using 2 adjacency.As shown in the figure, this separation is inclined plane with adjustment face 23.Process to the 2nd the mirror finish applying with face 2 and adopt the method identical with the 1st above-mentioned processing face 1.In addition, the 2nd raw material of processing use portion 20 adopts with the 1st and processes the identical raw material of use portion 10.Separate inner peripheral surface 25 adjacency with the 2nd processing use portion 20 of ring-type with adjustment face 23.

In the bottom (bottom) of the 2nd bracket 21, form annulus resettlement section 41, O shape annulus and the 2nd is processed and is housed in this annulus resettlement section 41 together with portion 20.And, do not accommodated rotatably with respect to the 2nd bracket 21 with portion 20 by 84, the 2 processing of spline pin.Above-mentioned the 2nd processing is exposed from the 2nd bracket 21 with face 2.Under this state, the 2nd processing is faced with the 1st processing face 1 of face 2 and the 1st processing portion 10.

The annulus resettlement section 41 that the 2nd bracket 21 has be accommodate the 2nd annulus 20, be mainly the recess of processing with the position of the opposition side of face 2 sides, in the time overlooking, be the groove that forms ring-type.

Annulus resettlement section 41 forms in the mode of the size that is greater than the 2nd annulus 20, between itself and the 2nd annulus 20, has sufficient interval, accommodates the 2nd annulus 20.

By this interval, the 2nd processes with portion 20 with can be in the axial of resettlement section 41 and being housed in this annulus resettlement section 41 with the mode of this direction displacement axially intersecting.And the 2nd processing is accommodated in the mode of displacement as follows with portion 20, that is, with respect to annulus resettlement section 41, make the 2nd processing centrage (direction of principal axis) of use portion 20 and the direction of principal axis of above-mentioned annulus resettlement section 41 not parallel.

At least in the annulus resettlement section 41 of the 2nd bracket 21, be provided with as the spring 43 of processing use portion elastic pressing part.Spring 43 suppresses with portion 20 the 2nd processing to the 1st processing portion 10.And, as other the method for suppressing, also can use the pressurization means of air introduction part 44 air supply pressure such as grade or other fluid pressure, the 2nd processing portion 20 that the 2nd bracket 21 is kept suppresses towards approaching the 1st processing direction of portion 10.

The pressure of contact surface imparting mechanisms such as spring 43 and air introduction part 44 suppress the 2nd each position (processing the each position with face) of processing with the Zhou Fangxiang of portion 20 equably to the 1st processing portion 10.

Be provided with above-mentioned the 1st introduction part d1 in the central authorities of the 2nd bracket 21, first be imported in following space by the fluid of force feed with portion's outer circumferential side towards processing from the 1st introduction part d1, the 2nd processing portion 20, the 1st that, the 2nd bracket 21 keeps processes with portion 10 and keeps the 1st to process in the space of enclosing with the 1st bracket 11 of portion 10.And, make the 2nd processing portion 20 overcome suppressing of elastic pressing part and process the direction separating with portion 10 from the 1st, on the compression face 23 arranging, be subject to the discharge pressure (supply pressure) of the above-mentioned fluid producing from fluid pressure imparting mechanism P in the 2nd processes use portion 20.

What be explained is, in other position, for schematic illustration, though only compression face 23 is illustrated, still, correct, as Figure 29 (A) (B) as shown in, together with above-mentioned compression face 23, processing in the corresponding direction of principal axis perspective plane of use portion 20 with the 2nd of the recess 13 of aftermentioned channel form, the part 23X that is not provided with above-mentioned compression face 23, also as compression face, is subject to the discharge pressure (supply pressure) of the above-mentioned fluid that fluid pressure imparting mechanism P produces.

Also can be embodied as, above-mentioned compression face 23 is not set.In this case, as shown in Figure 26 (A), also can use by the 1st and process and rotate the processed liquid that obtains to processing by the importing effect (Micropump effect) between face with face 1, above-mentioned the 1st processing has pressure of contact surface imparting mechanism performance function with face 1 and the recess 13 of the channel form that forms.The Micropump effect here refers to, by the 1st rotation of processing with face 1, fluid in recess has speed and advances to the peripheral direction front end of recess 13, then the fluid of sending into the front end of recess 13 is further subject to the pressure from the interior Zhou Fangxiang of recess 13, final formation to the pressure that makes to process the direction separating with face, has simultaneously fluid is imported to the effect of processing with between face.And, even in the situation that not being rotated, being arranged at the fluid pressure of the 1st processing in the recess 13 of face 1 and finally acting on the 2nd processing with on face 2, the 2nd processes with face 2 as the compression face that acts on separation side.

Process with the recess 13 of face for being arranged at, can implement its degree of depth corresponding to the physical property of the fluid that contains object being treated and product, with respect to processing by the face gross area, number and shape in the horizontal direction.

Be explained, can be embodied as, above-mentioned compression face 23 is together arranged in a device with above-mentioned recess 13.

This recess 13, for the degree of depth, 1 μ m～50 μ m, more preferably 3 μ m～20 μ m, and for being arranged on the recess on face for above-mentioned processing, account for and process by 5%～50% of face entirety with respect to processing with the face gross area in the horizontal direction, preferably 15%～25%, its number is 3～50, preferably 8～24, be shaped as and processing by the bending on face or the shape of spiral extension, or for being the shape of L font bending.And the degree of depth has gradient, thus from high viscosity region to low viscosity region, even contain solid at the fluid that utilizes Micropump effect to import, also can by fluid stable import and process with between face.And, be arranged on to process and between importing side is processed with each recess inside face, can be connected to each other with the recess 13 on face, also can disconnect.

As mentioned above, compression face 23 is inclined plane.This inclined plane (compression face 23) forms as follows,, distance on upstream-side-end taking the flow direction of processed liquid as benchmark, relative with the processing face of processing use portion that is provided with recess 13 direction of principal axis is larger than the same distance of end of downstream side.And preferably the flow direction taking processed liquid on this inclined plane is arranged on the direction of principal axis perspective plane of above-mentioned recess 13 as the end of downstream side of benchmark.

Particularly, as shown in Figure 28 (A), the end of downstream side 60 of above-mentioned inclined plane (compression face 23) is arranged so that on the direction of principal axis perspective plane of above-mentioned recess 13.Processing with the angle θ 1 of face 2 preferably the scope of 0.1 ° to 85 ° with respect to the 2nd of above-mentioned inclined plane, more preferably the scope of 10 ° to 55 °, further preferably the scope of 15 ° to 45 °.This angle θ 1 can suitably change according to the character before treatment of object being treated.In addition, the end of downstream side 60 on above-mentioned inclined plane is arranged on lower area, that is, from the 1st process and start with the upstream-side-end 13-b of the recess 13 of the face 1 setting position that side is left 0.01mm downstream, till with end of downstream side 13-c upstream side leave in the region of position of 0.5mm.More preferably, be arranged on in lower area, that is, from upstream-side-end 13-b downstream side leave the position of 0.05mm, till with end of downstream side 13-c upstream side leave in the region of position of 1.0mm.Identical with the angle on above-mentioned inclined plane, for the position of this end of downstream side 60, also can suitably change according to the character of object being treated.In addition, also can be as shown in Figure 28 (B) using inclined plane (compression face 23) implement as arcwall face.Thus, can further carry out equably the importing of object being treated.

Recess 13, except connecting as described above, also can be embodied as the form of interruption.In the situation that being interrupted, the recess 13 of interruption, the 1st process and become above-mentioned 13-b by the upstream-side-end on the inner circumferential side of face 1; Same the 1st processing becomes 13-c by the upstream-side-end in the most peripheral side of face 1.

In addition, although above-mentioned middle recess 13 is formed on the 1st process with on face 1, by compression face 23, be formed on the 2nd process use face 2 on, but, also can be embodied as on the contrary recess 13 is formed on to the 2nd processing with on face 2, compression face 23 is formed on to the 1st and processes with on face 1.

Further, also can be: by recess 13 be formed on the 1st process with face 1 and the 2nd process with 2 liang of sides of face, that recess 13 and compression face 23 are alternately arranged on to the Zhou Fangxiang of each processing face 1,2 is upper, thus the 1st process with the recess 13 forming on face 1 and the 2nd process by compression face 23 subtends that form on face 2, simultaneously, the 1st process recess 13 subtends of using formation on face 2 with the compression face 23 of formation on face 1 and the 2nd processing.

Processing with on face, also can implement the groove different from recess 13.As concrete example, as shown in Figure 16 (F), Figure 16 (G), compared with the radial outside of recess 13 (Figure 16 (F)) or radially inner side (Figure 16 (G)), can implement the new recess 14 of radiated entends.This want extend in the case of process with the time of staying between face, processing high viscosity materials fluid be favourable.

Be explained, for the groove different from recess 13, shape, area, number, the degree of depth be not particularly limited.Can implement this groove according to object.

Process in use portion 20 the above-mentioned the 2nd, be independent of the stream of the fluid that is imported into above-mentioned processing face, form and have and the 2nd introduction part d2 of the processing peristome d20 communicating between face.

Particularly, the 2nd introduction part d2, as shown in Figure 27 (A), processes and uses face 2 to tilt with the elevation angle (θ 1) of regulation with respect to the 2nd from the 2nd above-mentioned importing direction of processing the peristome d20 that uses face 2.This elevation angle (θ 1) is set to be greater than 0 degree and is less than 90 degree, and in the case of the fast reaction of response speed, is preferably set to below above 45 degree of 1 degree.

In addition, as shown in Figure 27 (B), process by the importing direction of the peristome d20 of face 2 along thering is directivity in the plane of above-mentioned the 2nd processing with face 2 from the above-mentioned the 2nd.For the importing direction of the 2nd fluid, process with the composition Wei Cong center of the radial direction of face away from outer direction, and, be forward with the processing of rotation with the relative composition of the direction of rotation of the fluid between face.In other words, using the radial direction by peristome d20 the line segment of outer direction as datum line g, there is fixing angle (θ 2) from this datum line g to direction of rotation R.

For this angle (θ 2), be also set as being greater than 0 degree and be less than 90 degree, to the netting twine part of Figure 27 (B), from peristome, d20 is discharged from.And in the case of the fast reaction of response speed, this angle (θ 2) also can be little angle, in the case of the slow reaction of response speed, preferably this angle (θ 2) is set as large angle.In addition, this angle can change to implement by the various conditions of rotary speed of face etc. according to the kind of fluid, response speed, viscosity, processing.

The bore of peristome d20 is preferably 0.2 μ m～3000 μ m, more preferably 10 μ m～1000 μ m.In addition in fact, do not affect fluid mobile at the diameter of peristome d20, the diameter of the 2nd introduction part d2 is arranged within the scope of this.In addition, in the situation that requiring straightline propagation and require in diffusible situation, preferably make the variations such as the shape of peristome d20, these can change to implement by various conditions such as the rotary speeies of face according to the kind of fluid, response speed, viscosity, processing.

And, peristome d20 in above-mentioned other stream can be arranged on the outside diameter of following point,, from being arranged on the 1st point of processing flow direction while importing by Micropump effect with the recess of face 1 and be transformed to the flow direction of the helical form laminar flow forming between processing is with face., in Figure 26 (B), be preferably, more than 0.5mm from the 1st processing face outermost radial outside of processing the recess 13 arranging with face 1 to the distance n of radial outside.And in the situation that same fluid is arranged to multiple peristome, be preferably arranged on concentric circular.In addition, in the situation that different fluid is arranged to multiple peristome, be preferably arranged on the different concentric circular of radius.Reaction as with (1) A+B → C (2) C+D → E is carried out with order, effectively avoids A+B+C → F original so reaction generation, object being treated that should simultaneous reactions cannot effectively contact and do not react such problem.

Can be embodied as in addition, above-mentioned processing is immersed in fluid with portion, will between above-mentioned processing is with face, mix (reaction) and the fluid obtaining is directly put in the outside liquid or air gas in addition of processing use portion.

And also can be to just adding ultrasonic wave energy from the object being treated of processing between the face of using or processing face is discharged.

Then, in order to process with face 1 and the 2nd and to process and use between face 2 the above-mentioned the 1st, process with producing temperature difference between face, process and describe by the situation that thermoregulative mechanism (thermoregulation mechanism) J1, J2 one of are at least set of portion 10 and the 2nd processing portion 20 for the 1st.

Although there is no particular limitation for this thermoregulative mechanism,, to be cooled to object in the situation that, cooling end is arranged to the use portion 10,20 that processes.Particularly, cooling element that can electricity with pipe arrangement or the Peltier element etc. that frozen water, various cold medium passed through of medium as homoiothermic or chemically carry out cooling effect is installed on to the use portion 10,20 that processes.

To be heated to be object in the situation that, processing with being provided with heating part in portion 10,20.Particularly, using as homoiothermic with pipe arrangement or the electric heater etc. that steam, various thermal medium passed through of medium can electricity or the heater element that chemically carries out heating functioin be installed on the use portion 10,20 that processes.

In addition, the resettlement section that can use with medium with the new homoiothermic that processing directly contacts with portion also can be set in annulus resettlement section.Thus, can utilize and process the homoiothermic of processing the face of using with the conduction of heat of portion.And, cooling element, heater element are imbedded and are processed in use portion 10,20 and energising, or imbed cold and hot medium by with passage and make medium homoiothermic for (cold and hot medium) pass through this passage, thereby can carry out homoiothermic with face from inner side to processing.Be explained, thermoregulative mechanism J1, J2 shown in Figure 25 are one example, are arranged on the pipe arrangement (big envelope) that the homoiothermic of each processing portion 10,20 inside is passed through with medium.

Utilize above-mentioned thermoregulative mechanism J1, J 2, make a side processing use the temperature of face higher than the opposing party's processing surface temperature, between processing with face, produce temperature difference.For example, the 1st processing is heated to 60 DEG C with above-mentioned method arbitrarily with portion 10, the 2nd processing is heated to 15 DEG C with above-mentioned method arbitrarily with portion 20.Now, import the temperature of processing with the fluid between face and be changed to 15 DEG C to the 2nd processing face 2 from 60 DEG C from the 1st processing face 1., this processing is with producing thermograde in the fluid between face.And processing, produces with respect to processing flowing by face vertical direction because this thermograde starts convection current with the fluid between face.Be explained, above-mentioned " flowing of vertical direction " refers in mobile direction composition, at least contains the composition of vertical above-mentioned processing face.

Even in the situation that the 1st processing is rotated with face 2 with face 1 or the 2nd processing, owing to continuing with flowing of face vertical direction with respect to this processing, therefore, can be to processing mobile the mobile of vertical direction that add that is rotated the helical form laminar flow between produced processing face with face.This processing can be embodied as 1 DEG C～400 DEG C by the temperature difference between face, is preferably 5 DEG C～100 DEG C.

Be explained, the rotating shaft 50 in this device is not defined as vertically configuration.For example also can be configuration obliquely.This is because in processing, by the thin film with the fluid forming between face 1,2 in two processing, can get rid of in fact the impact of gravity.As shown in figure 25, the 1st introduction part d1 is consistent with the axle center of the 2nd annulus 20 in the 2nd bracket 21, and vertically extends up and down.But, the 1st introduction part d1 is not limited to consistent with the axle center of the 2nd annulus 20, if can supply with the 1st processed liquid to two annulus 10,20 enclosed spaces, in the middle body 22 of the 2nd bracket 21, also can be arranged on position in addition, above-mentioned axle center, and, also can be non-perpendicular but oblique extension.Which no matter, the in the situation that of in arrangement angles, by the thermograde of processing between face, can produce with respect to processing with vertical the flowing of face.

In the thermograde of above-mentioned processing with the fluid between face, if its thermograde is little, only carry out convection cell conduction of heat, if but thermograde exceedes certain marginal value, in fluid, produce so-called shellfish Nader (ベ Na one Le) to flow phenomenon.This phenomenon, be that L, acceleration of gravity are that the volume thermal expansion rate of g, fluid is that the kinematic coefficient of viscosity of β, fluid is that the temperature conductivity of ν, fluid is α, processes while being Δ T by the temperature difference between face processing by the distance between face, the several Ra of Rayleigh (レイリ mono-) of the dimensionless number being defined with following formula arrange.

Ra＝L ³·g·β·ΔT/(α·ν)

The critical Rayleigh number that starts to produce Great draught is different from the interfacial character of object being treated fluid according to processing with face, but is approximately 1700.When larger than it, produce Great draught.And, be greater than 10 when this Rayleigh number Ra meets ¹⁰near the condition of value time, fluid is turbulent condition.; regulate this device by regulating the temperature difference Δ T of this processing between face or processing by the distance L of face so that Rayleigh number Ra is more than 1700 mode; can, processing with producing between face with respect to processing flowing of the face of using vertical direction, can implement above-mentioned mixing (reaction) operation.

But the processing of above-mentioned Great draught about 1～10 μ m is with being difficult to generation in the distance between face.Tight, above-mentioned Rayleigh number is applicable to the fluid in the interval below 10 μ m, in the time studying the occurrence condition of Great draught, and water if, its temperature difference is necessary for more than thousands of DEG C, is difficult to realize in reality.Great draught is the convection current being formed by the density contrast of the thermograde of fluid, i.e. the convection current relevant to gravity.Processing below 10 μ m is high by the probability that between face is Microgravity, and in such situation, buoyancy convection current is suppressed.What, in this device, produce realistically Great draught is the situation that exceedes 10 μ m by the distance between face processing.

When processing while being 1～10 μ m left and right by the distance between face, not produce convection current by density contrast, produce convection current but the surface tension of the fluid producing by thermograde is poor.Such convection current is Herba Kalimeridis brother Buddhist nun (マラ Application go ニ) convection current, process with the temperature conductivity that the kinematic coefficient of viscosity that the distance between face is L, fluid is ν, fluid be α, process with the density that the temperature difference between face is Δ T, fluid be ρ, capillary temperature coefficient (capillary thermograde) while being σ, the Herba Kalimeridis brother Buddhist nun number of the dimensionless number being defined by following formula is arranged.

Ma＝σ·ΔT·L/(ρ·ν·α)

The critical Herba Kalimeridis brother Buddhist nun number that starts to produce Marangoni Convection is 80 left and right, under the condition that is greater than this value, produces Marangoni Convection.; by regulate the temperature difference Δ T of this processing between face or process by the distance L of face, to regulate this to install to make Herba Kalimeridis brother Buddhist nun to count Ma be more than 80; even if the small stream below 10 μ m also can, processing with producing between face with respect to processing flowing of the face of using vertical direction, can be implemented above-mentioned mixing (reaction) operation.

The calculating of Rayleigh number is used following formula.

[numerical expression 1]

Ra = \frac{L^{3} \cdot β \cdot g}{v \cdot α} ΔT

Δ T=(T ₁one T ₀)

α = \frac{k}{ρ \cdot C_{p}}

L: process with the distance [m] between face, β: volume thermal expansion rate [1/K], g: acceleration of gravity [m/s ²]

ν: kinematic coefficient of viscosity [m ²/ s], α: temperature conductivity [(m ²/ s)], Δ T: process by the temperature difference [K] between face

ρ: density [kg/m ³], C p: specific heat at constant pressure [J/kgK], k: pyroconductivity [W/mK]

T ₁: process the temperature [K] with the high temperature side in face, T ₀: process the temperature [K] with the low temperature side in face

In the Rayleigh number when starting to produce Great draught as critical Rayleigh number Ra _csituation under, temperature difference Δ T now _c1can try to achieve as follows.

[numerical expression 2]

{ΔT}_{C 1} = \frac{{Ra}_{c} \cdot v \cdot α}{L^{3} \cdot β \cdot g}

The calculating of Herba Kalimeridis brother Buddhist nun number is used following formula.

[numerical expression 3]

Ma = \frac{σ_{t} \cdot L}{ρ \cdot v \cdot α} ΔT

ΔT＝(T ₁-T ₀)

α = \frac{k}{ρ \cdot C_{p}}

L: process with the distance [m] between face, ν: kinematic coefficient of viscosity [m ²/ s], α: temperature conductivity [(m ²/ s)]

Δ T: process with the temperature difference [K] between face, ρ: density [kg/m ³], Cp: specific heat at constant pressure [J/kgK]

K: pyroconductivity [W/mK], σ _t: surface tension temperature coefficient [N/mK]

The Herba Kalimeridis brother Buddhist nun number that starts to produce Marangoni Convection is being counted to Ma as critical Herba Kalimeridis brother Buddhist nun _csituation under, temperature difference Δ T now _c2can try to achieve as follows.

[numerical expression 4]

{ΔT}_{C 2} = \frac{{Ma}_{C} \cdot ρ \cdot v \cdot α}{σ_{t} \cdot L}

Can approach the material of mutual subtend processing that arrange, that at least one party is rotated with respect to the opposing party face 1,2 discretely, do not do special restriction, can with pottery, sintering metal, abrasion performance steel, other metal implemented the material of cured, to hard material carry out liner, coating, the material of having carried out plating etc. etc. makes.The distance that the mutual subtend of the approached separation in the present invention processing face that arrange, that at least one party is rotated with respect to the opposing party is 1,2 is 0.1 μ m～100 μ m, is particularly preferably 1～10 μ m.

Below, to being described in detail for the operation that obtains biological uptake thing of the present invention.

Particularly, at the processing face with the approached separation that subtend arranges, the processing that at least one party is rotated with respect to the opposing party is with between face, disperse solvent as the 1st fluid (processed liquid) water system, using the oil-phase component that contains fat-soluble pharmacological active substance as the 2nd fluid (processed liquid), by each fluid to keep state independently by the independently path corresponding to each fluid, import and process with between face, form thin film fluid, the fine particle that obtains having therein desirable particle diameter by mixing each fluid is biological uptake thing.This biological uptake thing, as the dispersion liquid of O/W shape that above-mentioned the 1st fluid is continuous phase, above-mentioned the 2nd fluid exists as decentralized photo in this continuous phase, from above-mentioned processing with being removed between face.In addition, in the situation that using surfactant, can in two sides of the 1st fluid or the 2nd fluid or each fluid, suitably add.

Be explained, said pharmacological active substance here, refers to the material monomer and the compound that biological performance are gone out to physiological action or pharmacological action.For example, the meaning refers to pharmaceuticals quasi drug, contained active ingredient in food food additives health food cosmetics vitamin etc.

In addition, at the processing face with the approached separation that subtend arranges, the processing that at least one party is rotated with respect to the opposing party is with between face, disperse solvent as the 1st fluid (processed liquid) oil system, using the water-phase component that contains water miscible pharmacological active substance as the 2nd fluid (processed liquid), by each fluid to keep state independently by the independently path corresponding to each fluid, import and process with between face, form thin film fluid, by mixing therein each fluid, the fine particle that obtains having desirable particle diameter is biological uptake thing.This biological uptake thing is also with above-mentioned the same, as the dispersion liquid of the W/O shape that above-mentioned the 1st fluid is continuous phase, above-mentioned the 2nd fluid exists as decentralized photo in this continuous phase, from above-mentioned processing with being removed between face.

Owing to carrying out the mixing of each fluid as mentioned above in each thin film fluid, therefore do not use inhomogeneous preparation to disperse modulator, can directly modulate, often produce uniform mixing field, therefore can easily obtain the biological uptake thing as object particle diameter.

As mentioned above, because each fluid is to keep independently state to be imported between processing face, therefore can each fluid be mixed to the ready-mixed operation of necessity before therefore can omitting in the thin film fluid forming.Thus, can be with more low-yield the biological uptake thing that obtains than in the past.

Be explained, the appellation of the 1st, the 2nd in each fluid described herein, represents that the n of multiple fluids is individual, and just the mark in order to identify, also can exist more than the 3rd fluid.If use more than the 3rd fluid, in the time of the manufacture of the liposome that contains complex emulsions particle or oil phase and water-phase component, be useful.

In the manufacture of biological uptake thing, except pharmacological active substance as required, can in decentralized photo or continuous phase, add various materials.For example, such as, by low molecule or high molecular modification material, the saccharide of aminoacid, peptide, transferrins, galactose or mannose etc., import above-mentioned thin film fluid from path independently, mix with above-mentioned each fluid, thus can be by desirable modification material by the surface stabilization of biological uptake thing.In addition, for pharmacological active substance, be also not limited to above-mentioned combination, can add in arbitrary fluid of decentralized photo and continuous phase, according to circumstances also can add in two sides' fluid.

The particle diameter of the biological uptake thing obtaining by above-mentioned operation, unnecessary because the ready-mixed of continuous phase and decentralized photo becomes, can there is not inhomogeneous stuff and other stuff, in addition, because can cast equably energy, compared with former method, can carry out single dispersion.In addition, process the interval of use portion and the 2nd processing use portion by free adjustment the 1st, controlled granulation footpath.

In addition, in the time of the manufacture of biological uptake thing, for example, shown in Figure 18 (A), use like that drawdown pump Q, by the 1st processing with portion 10 and the 2nd processing with the outside of portion 20, the surrounding of stream that processed liquid passes through becomes decompression state (comprising vacuum state), can carry out degassed or carry out desolventizing air contained in the processed liquid in emulsion and liposome chemical industry order or the molten gas of oxygen etc., lower boiling organic solvent, the steam etc. deposited.Like this, because the fluid that contains biological uptake thing being obtained by mixing between processing with face is discharged with atomize from processing with face, therefore the surface area of this fluid increases, and has advantages of that degassed desolventizing efficiency is very high.Degassed like this or desolventizing the long-time stability excellence of handled thing (biological uptake thing).

In the manufacture method of the liposome as biological uptake thing, make at least either party of the processed liquid of decentralized photo or continuous phase, contain as more than one in natural and synthetic phospholipid matter, their hydrogenated derivatives and their mixture.

Above-mentioned phospholipid, particularly, can enumerate and be selected from phosphatidylcholine, PHOSPHATIDYL ETHANOLAMINE, Phosphatidylserine, phosphatidic acid, phosphatidyl glycerol, phosphatidylinositols, cuorin, Ovum Gallus domesticus Flavus lecithin, soybean lecithin, hydrogenated yolk lecithin, the phosphoglyceride class of hydrogenated soy phosphatidyl choline etc., be selected from ス Off イ Application go エミリ Application, ceramide phosphoryl ethanolamine (ceramidephosphorylethanolamine), the sphingomyelins of ceramide phosphoryl glycerol etc., Plasmalogens, digalactosyl diglyceride, the glycerol lipid of galactosyl diglyceride sulfuric ester etc. etc.

Apart from the above, also can contain: amphiphilic compound, ionic and nonionic surfactant, glycosyl sphingolipid (for example, galactosyl ceramide, glycosyl ceramide, galactosyl ceramide sulfuric ester, lactosyl ceramides porcine, ganglioside G7, ganglioside G6, ganglioside G4), physiological bile salt (for example, sodium cholate, sodium dehydrocholate, NaTDC, sodium glycocholate and sodium taurocholate), saturated and unsaturated fatty acid or fatty alcohol, ethoxylated fatty acid or fatty alcohol, ester and ether with these materials, alkylaryl-Aethoxy Sklerol (for example tyloxapol), the ester of sugar or sugar alcohol and fatty acid or fatty alcohol and ether, acetylation or ethoxylation list-and two glyceride, synthesising biological decomposability polymer (block copolymer of for example poly(ethylene oxide) and poly(propylene oxide) oxide), ethoxylation dehydrated sorbitol ester or sorbitan ether, aminoacid, polypeptide and protein (for example gelatin and albumin), sterol (for example plant sterol, cholesterol) and tocopherol.

In the constituent of biological uptake thing, have unsaturated fatty acid, in order to prevent the oxidation of lipid, preferably, to processing with importing the such noble gas of nitrogen or argon between face, in this environment, process.For example, process with being full of with above-mentioned noble gas around the stream that portion and the 2nd processes with the outside of portion, processed liquid passes through the 1st.

In the manufacture of biological uptake thing, the water system using in continuous phase is disperseed the water-phase component using in solvent or decentralized photo, as long as be the upper acceptable liquid of pharmacology, do not do special restriction, can enumerate water, buffer, ethanol, propylene glycol, dimethyl sulfoxide (DMSO) or methyl iso-butyl ketone (MIBK) (MIBK) or their mixture etc.Wherein, preferred water or buffer.

In the manufacture of biological uptake thing, the oil system using in continuous phase disperses the oil-phase component using in solvent or decentralized photo, except the natural oil of soybean oil, Fructus Canarii albi wet goods, can use artificial oil.

In the manufacture of biological uptake thing, in decentralized photo composition, contain the material with phase transition temperature, by processing the thin film fluid forming between with face, to adjust to phase transition temperature be the temperature range of+5～+ 45 DEG C, after this, the biological uptake thing obtaining in thin film fluid is chilled to below phase transition temperature, obtains thus desirable biological uptake thing.The reason of carrying out chilling is in order to be not cause the biological uptake thing coagulation that manufactures or merging, livering.

For example, the phase transition temperature of phospholipid, dimyristoyl phosphatidyl choline is 23～24 DEG C, and two palmityl phosphatidyl cholines are 41.0～41.5 DEG C, and distearyl phosphatidyl choline is 54.1～58.0 DEG C, and hydrogenated soy phosphatidyl choline is approximately 53 DEG C.

Be explained, the liposome obtaining and microemulsion particle, available preferably 0.45 μ m, more preferably the filter of 0.22 μ m carries out aseptic filtration.

In addition, the liposome obtaining by the present invention and microemulsion particle, more than one month, do not find the formation of visible agglutination body at dark cold place (4 DEG C).Thereby, the liposome obtaining by the present invention and microemulsion particle excellent in stability.Be explained, the volume average particle size in the particle size distribution of the biological uptake thing obtaining is 10～400nm, particularly excellent in stability.

The biological uptake thing obtaining by the present invention, as long as to absorb in biology as object, it is not particularly limited, for example can be medicament capsule, transdermal formulation, oral formulations, immunoadjuvant, artificial red blood cell, the pharmaceuticals of artificial platelet etc. show the material of certain effect like that in vivo, and the transmission material of the ingredient of drug-supplying system, gene delivery system, or as cosmetics, be coated on paste formulation or lotion and the hair restoring and curing agent on skin, or food or food additives, health food, spice etc.

Like this, the manufacture method of biological uptake thing of the present invention, do not need indispensable preparation dispersion step till now, and, get rid of the impact of various medicines unequal coordination in preparation dispersity or unequal thermal history, the unequal energy amount of casting, often produce new mixing field, therefore can obtain uniform particle diameter.And, owing to can easily freely regulating the 1st processing use portion and the 2nd to process the interval of use portion, therefore can freely control particle diameter.Thus, can simplify flow chart, compared with former method, can obtain at short notice desirable particle, energy efficiency is good, and productivity ratio is good.

Embodiment

Below, describe in more detail for disclosed embodiment of the present invention.But the present invention has more than and is defined in these embodiment.Embodiment 1～4 and 9～21 is the embodiment of related lipase plastid, and embodiment 5～8 is the embodiment about microemulsion particle.

What be explained is, in following embodiment, so-called " from central authorities ", refer to such an extent that be the meaning of " from the 1st introduction part d1 " of blood processor shown in above-mentioned, Fig. 1 (A), the 1st fluid refers to the 1st above-mentioned processed liquid, and that the 2nd fluid refers to is above-mentioned, " the 2nd processed liquid that import, above-mentioned from the 2nd introduction part d2 of blood processor shown in Fig. 1 (A).

(embodiment 1)

From central authorities using the mixed liquor of 20% aqueous trehalose solution 240g and 10% Osmitrol 60g as the 1st fluid, be heated to 85 DEG C, carry out liquor charging to supply with pressure/back pressure=0.13MPa/0.12Mpa, rotating speed 5000rpm, to mix, heating for dissolving hydrogenation (hydrogenation) soybean lecithin 12g, cholesterol 6g, 1, the solution of 3-butanediol 24g, p-Hydroxybenzoate 1.2g is as the 2nd fluid, import to the 1st and process with between face 1 and the 2nd processing face 2, discharge liquor mixes in the mode of 90ml/min.Processing time is that every 300g treating capacity is 3.3min.In addition, discharge liquor is chilled to below 35 DEG C discharging between each processing use portion.

Solution after above-mentioned processing, uses the particle size distribution device (day machine dress (strain) goods, trade name microtrac UPA150) of having applied using dynamic light scattering method as measuring principle to measure, and result volume average particle size is 45.8nm.

(embodiment 2)

From central authorities using the mixed liquor of 20% aqueous trehalose solution 240g and 10% Osmitrol 6g as the 1st fluid heating to 85 DEG C, carry out liquor charging to supply with pressure/back pressure=0.11MPa/0.12MPa, rotating speed 8000rpm, to mix, heating for dissolving hydrogenated soy phosphatidyl choline 12g, cholesterol 6g, 1, the solution of 3-butanediol 24g, p-Hydroxybenzoate 1.2g is as the 2nd fluid, import the 1st and process with between face 1 and the 2nd processing face 2, discharge liquor mixes in the mode of 90ml/min.Processing time is that every 300g treating capacity is 3.3min.In addition, discharge liquor is chilled to below 35 DEG C discharging between each processing use portion.

Solution after above-mentioned processing, uses the particle size distribution device (day machine dress (strain) goods, trade name microtrac UPA150) of having applied using dynamic light scattering method as measuring principle to measure, and result volume average particle size is 21.6nm.

(embodiment 3)

From central authorities using the mixed liquor of 20% aqueous trehalose solution 240g and 10% Osmitrol 60g as the 1st fluid heating to 85 DEG C, carry out liquor charging to supply with pressure/back pressure=0.14MPa/0.12Mpa, rotating speed 3000rpm, to mix, heating for dissolving hydrogenated soy phosphatidyl choline 12g, cholesterol 6g, 1, the solution of 3-butanediol 24g, p-Hydroxybenzoate 1.2g is as the 2nd fluid, import the 1st and process with between face 1 and the 2nd processing face 2, discharge liquor mixes in the mode of 90ml/min.Processing time is that every 300g treating capacity is 3.3min.In addition, discharge liquor is chilled to below 35 DEG C discharging between each processing use portion.

Solution after above-mentioned processing, uses the particle size distribution device (day machine dress (strain) goods, trade name microtrac UPA150) of having applied using dynamic light scattering method as measuring principle to measure, and result volume average particle size is 60.9nm.

(embodiment 4)

From central authorities using the mixed liquor of 20% aqueous trehalose solution 240g and 10% Osmitrol 60g as the 1st fluid, be heated to 85 DEG C, supplying with pressure/back pressure=0.14MPa/0.25MPa, rotating speed 5000rpm carries out liquor charging; To mix, heating for dissolving hydrogenated soy phosphatidyl choline 12g, cholesterol 6g, 1, the solution of 3-butanediol 24g, p-Hydroxybenzoate 1.2g is as the 2nd fluid, import the 1st and process with between face 1 and the 2nd processing face 2, discharge liquor mixes in the mode of 30ml/min.In addition, discharge liquor is chilled to below 35 DEG C discharging between each processing use portion.

Solution after above-mentioned processing, uses the particle size distribution device (day machine dress (strain) goods, trade name microtrac UPA150) of having applied using dynamic light scattering method as measuring principle to measure, and result volume average particle size is 36.8nm.

(comparative example 1)

In heating for dissolving hydrogenated soy phosphatidyl choline 10.5g, cholesterol 5.25g, 1, in the liquid of 3-butanediol 21g, p-Hydroxybenzoate 1.05g, add 20% aqueous trehalose solution 210g, 10% Osmitrol 52.5g, after homoiothermic to 85 DEG C, use homogenizer (M technology society system, ClearMix W-motion) process 10min with rotor 18000rpm/ ス Network リ mono-Application 17000rpm, be chilled to below 35 DEG C with the each 6000rpm of rotor/ス Network リ mono-Application thereafter.

Solution after above-mentioned processing, uses the particle size distribution device (day machine dress (strain) goods, trade name microtrac UPA150) of having applied using dynamic light scattering method as measuring principle to measure, and result volume average particle size is 63.8nm.

(comparative example 2)

In heating for dissolving hydrogenated soy phosphatidyl choline 10.5g, cholesterol 5.25g, 1, in the solution of 3-butanediol 21g, p-Hydroxybenzoate 1.05g, add 20% aqueous trehalose solution 210g, 10% Osmitrol 52.5g, after using homogenizer (ClearMix) loose with 8000rpm rough segmentation, use emulsion dispersion machine (SS5 processed of M technology society) to process with 85 DEG C of rotating speed 5000rpm, temperature, discharge liquor is 30ml/min.

Solution after above-mentioned processing, uses the particle size distribution device (day machine dress (strain) goods, trade name microtrac UPA150) of having applied using dynamic light scattering method as measuring principle to measure, and result volume average particle size is 56.8nm.

[table 1]

	Embodiment 1	Embodiment 2	Embodiment 3	Embodiment 4	Comparative example 1	Comparative example 2
							Rotating speed [rpm]	5000	8000	3000	5000	18000/17000	5000
Processing time [min]	3.3	3.3	3.3	10	10	10
							Particle diameter D ₅₀[nm]	45.8	21.6	60.9	36.8	63.8	56.8
Energy is cast rate [-]	0.074	0.351	0.019	0.257	1	0.93

Attention: treating capacity is all set as 300g, composition ultimate density is set as necessarily.

The processing time of embodiment 1～4 is set as 300g and processes the needed time

As shown in table 1, needed energy in liposome, compared with comparative example 1, embodiments of the invention 1 are approximately 1/14th, embodiment 2 for approximately 1/3rd, embodiment 3 for approximately 1/53rd, embodiment 4 be approximately 1/4th.In addition, compared with comparative example 2, embodiments of the invention 1 are approximately 1/13rd, embodiment 2 is approximately 1/3rd, embodiment 3 for approximately 1/49th, embodiment 4 be approximately 1/4th.Hence one can see that, the energy efficiency excellence of the manufacture method of above-described embodiment.

(embodiment 5)

The solution that will mix concentrated glycerin 22.1g and pH adjusting agent (sodium hydrate aqueous solution) from central authorities among water for injection 853.5g is as the 1st fluid, carry out liquor charging to supply with pressure/back pressure=0.020MPa/0.01MPa, rotating speed 1000rpm, to in the mixed liquor of refining olive oil 100g and highly purified Ovum Gallus domesticus Flavus lecithin 18g, oleic acid 2.4g, add PGE1 5mg and then carry out solution that stirring and dissolving forms as the 2nd fluid, import the 1st and process with between face 1 and the 2nd processing face 2, discharge liquor mixes in the mode of 50ml/min.Processing time is that every 300g treating capacity is 6min.

Solution after above-mentioned processing, uses the particle size distribution device (SIMAZU society system, trade name SALD-7000) of having applied using laser diffraction and scattering method as measuring principle to measure, and result volume average particle size is 70.4nm.

(embodiment 6)

The solution that will mix concentrated glycerin 22.1g and pH adjusting agent (sodium hydrate aqueous solution) from central authorities among water for injection 853.5g is as the 1st fluid, carry out liquor charging to supply with pressure/back pressure=0.010MPa/0.01MPa, rotating speed 2000rpm, to in the mixed liquor of refining olive oil 100g and highly purified Ovum Gallus domesticus Flavus lecithin 18g, oleic acid 2.4g, add PGE1 5mg and then carry out solution that stirring and dissolving forms as the 2nd fluid, import the 1st and process with between face 1 and the 2nd processing face 2, discharge liquor mixes in the mode of 50ml/min.Processing time is that every 300g treating capacity is 6min.

Solution after above-mentioned processing, uses the particle size distribution device (SIMAZU society system, trade name SALD-7000) of having applied using laser diffraction and scattering method as measuring principle to measure, and result volume average particle size is 38.3nm.

(embodiment 7)

The solution that will mix concentrated glycerin 22.1g and pH adjusting agent (sodium hydrate aqueous solution) from central authorities among water for injection 853.5g is as the 1st fluid, carry out liquor charging to supply with pressure/back pressure=0.015MPa/0.01Mpa, rotating speed 1500rpm, to in the mixed liquor of refining olive oil 100g and highly purified Ovum Gallus domesticus Flavus lecithin 18g, oleic acid 2.4g, add solution that PGE1 5mg and then stirring and dissolving form as the 2nd fluid, import the 1st and process with between face 1 and the 2nd processing face 2, discharge liquor mixes in the mode of 50ml/min.Processing time is that every 300g treating capacity is 6min.

Solution after above-mentioned processing, uses the particle size distribution device (SIMAZU society system, trade name SALD-7000) of having applied using laser diffraction and scattering method as measuring principle to measure, and result volume average particle size is 68.5nm.

(embodiment 8)

The solution that will mix concentrated glycerin 22.1g and pH adjusting agent (sodium hydrate aqueous solution) from central authorities among water for injection 853.5g is as the 1st fluid, carry out liquor charging to supply with pressure/back pressure=0.040MPa/0.01Mpa, rotating speed 1500rpm, to in the mixed liquor of refining olive oil 100g and highly purified Ovum Gallus domesticus Flavus lecithin 18g, oleic acid 2.4g, add solution that PGE1 5mg and then stirring and dissolving form as the 2nd fluid, import the 1st and process with between face 1 and the 2nd processing face 2, discharge liquor mixes in the mode of 100ml/min.Processing time is that every 300g treating capacity is 3min.

Solution after above-mentioned processing, uses the particle size distribution device (SIMAZU society system, trade name SALD-7000) of having applied using laser diffraction and scattering method as measuring principle to measure, and result volume average particle size is 70.1nm.

(comparative example 3)

In water for injection 257.08g, add concentrated glycerin 6.65g to be uniformly mixed.In addition, stirring and dissolving is refined olive oil 30.12g, highly purified Ovum Gallus domesticus Flavus lecithin 5.42g, oleic acid 0.73g, adds wherein PGE1 1.5mg, and then stirring and dissolving.Added in the mixed liquid of the previous water for injection of having adjusted and glycerol, use homogenizer (M technology society system, ClearMix W-motion) process 10min with rotor 18000rpm/ ス Network リ mono-Application 17000rpm, adjust pH approximately 5 with sodium hydroxide, obtain the lipomul of PGE1.

Solution after above-mentioned processing, uses the particle size distribution device (SIMAZU society system, trade name SALD-7000) of having applied using laser diffraction and scattering method as measuring principle to measure, and result volume average particle size is 117.3nm.

(comparative example 4)

In water for injection 257.08g, add concentrated glycerin 6.65g to be uniformly mixed.In addition, stirring and dissolving is refined olive oil 30.12g, highly purified Ovum Gallus domesticus Flavus lecithin 5.42g, oleic acid 0.73g, adds wherein PGE1 1.5mg, and then stirring and dissolving.Added in the mixed liquid of the previous water for injection of having adjusted and glycerol, use emulsion dispersion machine (M technology society system, SS5), process 6min with rotating speed 5000rpm, discharge liquor is 50ml/min.With sodium hydroxide adjust pH approximately 5, obtain the lipomul of PGE1 thereafter.

Solution after above-mentioned processing, uses the particle size distribution device (SIMAZU society system, trade name SALD-7000) of having applied using laser diffraction and scattering method as measuring principle to measure, and result volume average particle size is 109.5nm.

[table 2]

	Embodiment 5	Embodiment 6	Embodiment 7	Embodiment 8	Comparative example 3	Comparative example 4
							Rotating speed [rpm]	1000	2000	1500	1500	18000/17000	5000
Processing time [min]	6	6	6	3	10	6
							Particle diameter D ₅₀[nm]	70.4	38.3	68.5	70.1	117.3	109.5
Energy is cast rate [-]	0.05	0.40	0.17	0.08	1	0.56

The processing time of embodiment 5～8 is set as 300g and processes the needed time

Needed energy in microemulsion liquefaction, compared with comparative example 3, embodiments of the invention 5 are approximately 1/20th, and embodiment 6 is approximately 1/3rd, and embodiment 7 is approximately 1/6th, and embodiment 8 is approximately 1/13rd.In addition, compared with comparative example 4, embodiments of the invention 5 are approximately 1/11.2nd, and embodiment 6 is approximately 1/1.4th, and embodiment 7 is approximately 1/3.3rd, and embodiment 8 is approximately 1/7.0th.Hence one can see that, the energy efficiency excellence of the manufacture method of above-described embodiment.

(embodiment 9～21)

Secondly, checking is due to the difference of the particle diameter of the caused biological uptake thing of difference of input temperature and chilling temperature after treatment.

Using having disperseed the liquid of 1.2g hydrogenated soy phosphatidyl choline as oil phase in 10g soybean oil, using the liquid that has dissolved 25g glycerol in 863g Purified Water as water, process with table 3 condition.Utilize blood processor as Fig. 1 (A) as shown in, that be uniformly mixed equably in the thin film fluid of the formation between processing face 1,2 that arrange, that at least one party is rotated with respect to the opposing party that can approach discretely subtend mutually, oil phase is collaborated with water in thin film fluid, evenly mix on one side and carry out emulsion dispersion on one side.

[table 3]

* the phase transition temperature of hydrogenated soy phosphatidyl choline is approximately 53 DEG C.

The measurement result of particle diameter is recorded in table 4.

[table 4]

	Particle diameter D50[nm]
		Embodiment 9	568.7
Embodiment 10	263.5
		Embodiment 11	84.6
Embodiment 12	72.9
		Embodiment 13	78.5
Embodiment 14	69.4
		Embodiment 15	326.8
Embodiment 16	70.8
		Embodiment 17	139.6
Embodiment 18	385.7
		Embodiment 19	368.9
Embodiment 20	376.9
		Embodiment 21	584.3

Be made as phase transition temperature+5～45 DEG C will drop into temperature (treatment temperature), chilling temperature is made as in 35 DEG C of following situations, can be in phase transition temperature+5 DEG C and obtain the particle below 100nm 45 DEG C time.In addition, the in the situation that of below phase transition temperature+5 DEG C, in result, can see inequality, particle diameter is 300nm left and right.In addition, chilling temperature is when more than 35 DEG C, has livering, merging, coagulation, forms larger particle diameter.It can be said that phase transition temperature+5～+ 45 DEG C, 35 DEG C of following temperature ranges of chilling temperature, the manufacture of the most applicable biological uptake thing.If consideration operability, preferably the temperature in above-mentioned temperature range and below the above boiling point of freezing point of dispersion solvent is carried out.

Claims

1. the manufacture method of biological uptake thing, is characterized in that, in the manufacture method of the microemulsion particle as biological uptake thing,

Have approached separation that subtend arranges for processing, face, at least one party are rotated with respect to the opposing party the 1st processes with face and the 2nd processing and import processed liquid between with face,

By the pressure of above-mentioned processed liquid, be created in and make the 2nd to process the power moving up with the side that face separates from the 1st processing face,

By this power, between processing with face with face and the 2nd, the 1st processing keeps small interval, and the above-mentioned processed liquid passing through between the 1st processing face and the 2nd that has kept this slight gap is processed with face forms thin film fluid,

Using the processed liquid of the decentralized photo of the oil-phase component that contains fat-soluble pharmacological active substance and at least disperse the processed liquid of the continuous phase that forms of solvent as above-mentioned processed liquid by water system, remaining respectively independently under state, by the independently path of the phase corresponding to separately, importing above-mentioned two processes with between face, in above-mentioned thin film fluid, mix above-mentioned processed liquid

Above-mentioned manufacture method has:

Processed liquid is given to the fluid pressure imparting mechanism of pressure,

The 1st handling part and with respect to the 1st process use portion can relatively approach separation the 2nd processing use portion at least 2 processing use portions, and

Make the 1st above-mentioned processing portion and the 2nd process the rotary drive mechanism being relatively rotated with portion;

In above-mentioned each processing use portion, mutually on the position of subtend, be provided with the 1st and process with face and the 2nd at least 2 processing faces processing with face;

Above-mentioned each processing forms a part for the above-mentioned processed liquid that has been endowed pressure stream that flow through, sealed with face;

, with between face above-mentioned processed liquid is evenly mixed in two above-mentioned processing;

The above-mentioned the 1st processes use portion and the 2nd processes in use portion, and at least the 2 processing has compression face with portion, and at least a portion of this compression face is made up of with face the 2nd above-mentioned processing,

This compression face is subject to above-mentioned fluid pressure imparting mechanism gives the pressure of processed liquid, is created in and makes the 2nd to process and process from the 1st the power moving up with the side of face separation with face;

By the above-mentioned processed liquid that has been endowed pressure is processed with between face by approaching the 1st processing face and the 2nd that separates and be relatively rotated, above-mentioned processed liquid forms the thin film fluid of the thickness below the interval between two processing face on one side, processes with between face on one side by two;

And, there is the other importing road that is independent of the stream that the above-mentioned processed liquid that has been endowed pressure flows through;

The above-mentioned the 1st processes and at least in any, has the peristome that at least one communicates with above-mentioned importing road with face with face and the 2nd processing;

At least one the processed liquid transporting from above-mentioned importing road is imported to above-mentioned two to be processed with between face, form thus above-mentioned thin film fluid, the processed liquid of above-mentioned decentralized photo is mixed in above-mentioned thin film fluid with processed liquids different from above-mentioned processed liquid, above-mentioned continuous phase, make thus composition contained in the processed liquid of above-mentioned decentralized photo form the fine particle with desirable particle diameter;

In the downstream that imports above-mentioned two flow directions while processing the passing through Micropump effect and import of processed liquid that has been endowed pressure with above-mentioned between face and be transformed to the point of the flow direction of the helical form laminar flow forming between above-mentioned two processing are with face, above-mentioned peristome is set.

2. the manufacture method of biological uptake thing, is characterized in that, in the manufacture method of the microemulsion particle as biological uptake thing,

Using the processed liquid of the decentralized photo of the water-phase component of the pharmacological active substance that contains containing water-soluble and at least disperse the processed liquid of the continuous phase that solvent forms as above-mentioned processed liquid by oil system, remaining respectively independently under state, by the independently path of the phase corresponding to separately, importing above-mentioned two processes with between face, in above-mentioned thin film fluid, mix above-mentioned processed liquid

Above-mentioned manufacture method has:

3. the manufacture method of biological uptake thing, is characterized in that, in the manufacture method of the liposome as biological uptake thing,

The phospholipid that the processed liquid of decentralized photo or the processed liquid of continuous phase at least contain more than one in either party,

The processed liquid of above-mentioned decentralized photo contains pharmacological active substance, and the processed active substance of above-mentioned continuous phase at least disperses solvent to form by water system,

Using the processed liquid of the processed liquid of above-mentioned decentralized photo and above-mentioned continuous phase as above-mentioned processed liquid, remaining respectively independently under state, by the independently path of the phase corresponding to separately, importing above-mentioned two processes with between face, in above-mentioned thin film fluid, mix above-mentioned processed liquid

Above-mentioned manufacture method has:

4. the manufacture method of biological uptake thing claimed in claim 3, it is characterized in that, in the manufacture method of the liposome as biological uptake thing, the above-mentioned phospholipid at least containing in either party in the processed liquid of decentralized photo or the processed liquid of continuous phase is natural and synthetic phospholipid matter, their hydrogenated derivatives and their mixture;

Apart from the above, contain and be selected from following at least one: amphiphilic compound, ionic and nonionic surfactant, glycosphingolipid, physiological bile salt, saturated and unsaturated fatty acid or fatty alcohol, ethoxylated fatty acid or fatty alcohol, and their ester and ether, alkylaryl-Aethoxy Sklerol, the ester of sugar or sugar alcohol and fatty acid or fatty alcohol and ether, acetylation or ethoxylation list-and two glyceride, synthesising biological decomposability polymer, ethoxylation dehydrated sorbitol ester or sorbitan ether, aminoacid, polypeptide and protein, sterol and tocopherol.

5. the manufacture method of the biological uptake thing described in any one of claim 1 to 4, is characterized in that, by the processed liquid of above-mentioned decentralized photo, imports above-mentioned two process with between face from above-mentioned other importing road.

6. the manufacture method of the biological uptake thing described in any one of claim 1 to 4, it is characterized in that, the manufacture method of above-mentioned biological uptake thing, can be omitted in by ready-mixed operation before between above-mentioned processing face, the processed liquid of continuous phase and the processed liquid of decentralized photo.

7. the manufacture method of the biological uptake thing described in any one of claim 1 to 4, it is characterized in that, the water system using in the processed liquid of continuous phase is disperseed the water-phase component using in the processed liquid of solvent or decentralized photo, is water, buffer, ethanol, propylene glycol, dimethyl sulfoxide or methyl iso-butyl ketone (MIBK) or their mixture, pharmaceutically acceptable liquid.

8. the manufacture method of the biological uptake thing described in any one of claim 1 to 4, it is characterized in that, in the manufacture of above-mentioned biological uptake thing, for the gas of air contained in above-mentioned processed liquid, dissolved oxygen, lower boiling organic solvent, steam are carried out to degassed or desolventizing, reduced pressure in the outside of the each processing portion that is provided with above-mentioned each processing face.

9. the manufacture method of the biological uptake thing described in any one of claim 1 to 4, it is characterized in that, in the manufacture of above-mentioned biological uptake thing, in the contained composition of the processed liquid of decentralized photo, contain the material with phase transition temperature, be adjusted to the temperature range of phase transition temperature+5～+ 45 DEG C and than also low temperature of the boiling point of the processed liquid of continuous phase by processing with the thin film fluid forming between face.

10. the manufacture method of the biological uptake thing described in any one of claim 1 to 4, it is characterized in that, in the manufacture of above-mentioned biological uptake thing, in the contained composition of the processed liquid of decentralized photo, contain the material with phase transition temperature, by processing that the biological uptake thing obtaining in the thin film fluid forming between with face is chilled to below 35 DEG C and than also high temperature of the freezing point of the processed liquid of continuous phase.