CN101889633B - Application of pioglitazone hydrochloride in live stock feed additive - Google Patents
Application of pioglitazone hydrochloride in live stock feed additive Download PDFInfo
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- CN101889633B CN101889633B CN200910214549XA CN200910214549A CN101889633B CN 101889633 B CN101889633 B CN 101889633B CN 200910214549X A CN200910214549X A CN 200910214549XA CN 200910214549 A CN200910214549 A CN 200910214549A CN 101889633 B CN101889633 B CN 101889633B
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Abstract
The invention discloses an application of pioglitazone hydrochloride in a live stock feed additive. The addition amount of the pioglitazone hydrochloride in the feed is 50-100 g/t. The live stock feed additive with the pioglitazone hydrochloride can increase the growth rate of live stock, increase the intramuscular fat content of live stock and improves the flavor, mouthfeel and quality of live stock meat. The additive also increases the conversion rate of the feed, reduces the cost and feed conversion ratio, enhances the economic benefit and enables the live stock to have higher market value.
Description
Technical field
The present invention relates to feed additive field, be specifically related to the application of pyrrolidine hydrochloride row ketone in poultry and livestock feed additive.
Background technology
Feed addictive is that one or more that in mixed feed, add separately for special requirement have the general name of different bioactive particular matters.Originally feed addictive just adds the deficiency that feed into is used for certain nutriment of supplement feed as a kind of trace nutrient, and the balanced feed nutrient comprises vitamin and inorganic salts etc.Along with animal nutrition and peripheral subject development thereof; Present feed addictive has merged each subject and multiple technologies; Its function, kind and application have obtained huge expansion; Miscellaneous non-nutritive additive occurred, like antibiotic, enzyme preparation, oligosaccharides, vermifuge etc., feed addictive production has become a comparatively industrial system of system.On the other hand; Along with the raising of life water article, the consumer has had higher requirement to fowl poultry meat matter, no matter is from local flavor angle or security standpoint; This also has higher requirement to feedstuff industry; How when reducing feed cost, improving the carcass quality of animal, guarantee the quality safety of livestock products, is a problem that is worth further investigation.
Pyrrolidine hydrochloride row ketone is mainly used in medical domain now, belongs to a kind of of thiazolidine dione compounds; Be mainly used in treatment diabetes B symptom; It is a kind of insulin sensitizer for a clinical research confirmation, has to reduce blood sugar concentration and the effect of removing fat and cholesterol in the blood, can improve glycolipid metabolism; Have gentle antihypertensive effect simultaneously, confirm human body is had no side effect through clinical trial.
Summary of the invention
The object of the invention is the deficiency according to prior art; Widened the range of application of pyrrolidine hydrochloride row ketone; Excavated the multiple effect of pyrrolidine hydrochloride row ketone in healthy fowl poultry body; Pyrrolidine hydrochloride row ketone is added in the poultry and livestock feed, and the poultry and livestock feed of gained can improve fowl poultry meat growth performance, improves fowl poultry meat matter.
Above-mentioned purpose of the present invention is achieved through following technical scheme:
The present invention has found to be different from the result that pyrrolidine hydrochloride row ketone is applied to people's clinical testing through animal feeding test and slaughter experiment, and pyrrolidine hydrochloride row ketone is as the new application of feed addictive.In the basal diet of pig, add pyrrolidine hydrochloride row ketone, can enliven fat transfer and increase intramuscular fat deposition in the muscle, detect the relative expression quantity of FABP3 in the longissimus dorsi muscle through quantitative RT-PCR; The expression of finding FABP3 raises, and fat is synthetic more active in the muscle, sees from apparent; The average daily gain of pig increases, and feed conversion rate improves, and the marble grain scoring improves; Intramuscular fat content increases, and growth performance of pig and meat matter all are improved; On the other hand; Through the relative expression quantity of the serum index of raising swinery being measured and being passed through GLUT4 in the RT-PCR detection longissimus dorsi muscle; The glucose content that discovery has been fed in the swinery serum of pyrrolidine hydrochloride row ketone and the pyrrolidine hydrochloride row ketone of not feeding is more or less the same; Glucose is transported active degree in vivo not to be increased yet, and explains that pyrrolidine hydrochloride row ketone does not exert an influence to the glycometabolism of healthy individuals.
Similarly, as the feed addictive of other fowl poultrys, pyrrolidine hydrochloride row ketone can reach equally and promote growth, improves the effect of fowl poultry meat matter.
The addition of pyrrolidine hydrochloride row ketone of the present invention in feed is 50 ~ 100g/t.
The application of pyrrolidine hydrochloride row ketone of the present invention in poultry and livestock feed additive preferably is added on pyrrolidine hydrochloride row ketone in the pig feed, can reach best growth promotion effect.
Pyrrolidine hydrochloride row ketone feed addictive is the white powder material, and use amount is few, should preserve with the packaged refrigerator of putting into of sealing bag.With the miniature electric weighing, add according to a certain percentage before using,, then need the pyrrolidine hydrochloride row ketone feed addictive of 50 ~ 100g as producing 1 ton of complete feed.At first mix with premix after weighing is intact, note mixing with small-sized mixing apparatus.Or directly and carrier be mixed and made into pre-mixing agent.Just get into after premix is processed in the large-scale mixing disintegrating apparatus and mix, process complete feed with the primary raw material of complete diet pellets such as the corn of pulverizing, dregs of beans.
Compared with prior art, the present invention has following beneficial effect:
(1) poultry and livestock feed that has added pyrrolidine hydrochloride row ketone is a kind of safe feed; It does not contain swinery growth and the healthy poisonous and hazardous material of swinery; Medicine is in the intragroup residual safety standard amount that also reaches of pig; Can not produce adverse effect to people and surrounding environment, compare with general feed addictive, it also can play the effect that improves meat matter when improving the swinery growth performance.Compare with effect as medicine; Pyrrolidine hydrochloride row ketone is not to reduce blood pressure and blood lipoid as the effect of feed addictive, strengthens insulin sensitivity, and its effect shows the content that increases intramuscular fat; Improve meat matter, and improve average daily gain and the efficiency of feed utilization of pig;
(2) poultry and livestock feed that has added pyrrolidine hydrochloride row ketone can be accelerated the speed of growth of fowl poultry; Increase the intramuscular fat content of fowl poultry; Improve local flavor, mouthfeel and the quality of fowl poultry meat, this additive has also increased the conversion ratio of feed, has reduced cost and material anharmonic ratio; Improved economic benefit, made the fowl poultry have higher market value.After pyrrolidine hydrochloride row ketone in the feed gets in the animal body, activate the PPARgamma acceptor of target tissue, this acceptor plays important effect to the fat metabolic process in the control agent; Can activate the expression of a series of fat metabolic genes; Fat metabolism in the body is strengthened, and final result shows as intramuscular fat content to be increased, thereby causes the mouthfeel and the local flavor of fowl poultry meat to be greatly improved; Finally reach the purpose of improving meat matter, make fowl poultry meat product on market, can have certain advantage;
(3) pyrrolidine hydrochloride row ketone addition is little, can directly add in the premix, and the interpolation process convenient is quick.
Description of drawings
Fig. 1 is the influence of pyrrolidine hydrochloride row ketone to FABP3 gene mRNA in the longissimus dorsi muscle and GLUT4 gene mRNA expression amount;
Fig. 2 is the oil red O stain slice map (100 *) of the representative longissimus dorsi muscle sample of pig at microscopically, and wherein, left side figure is a control group, and right figure is an experimental group.
The specific embodiment
Come further to explain the present invention below in conjunction with embodiment, but embodiment does not do any type of qualification to the present invention.
Embodiment feeds to swinery according to following prescription:
Embodiment 1 pyrrolidine hydrochloride row ketone is to INFLUENCE OF YUCCA EXTRACT
In order to observe the effect of pyrrolidine hydrochloride row ketone, carried out feeding experiment twice respectively on November 22nd, 2007 to December 20 and on May 5th, 2009 to June 13 planting the pig farm in Zengcheng City, Guangdong Province Agricultural University Of South China as feed addictive.The pig of twice test is all for greatly enhancing the assorted pig of binary, and the test pig beginning average weight of all rising is 54 kilograms for the first time, it raised stage definitions be fattening early stage; The initial average weight of swinery is 70 kilograms for the second time, it is raised stage definitions be the fattening middle and later periods.
Test is adjusted swinery the phase of raising in advance, and a hurdle i.e. a repeating groups, every hurdle (repetition) 8 pigs, and totally 10 hurdles (repetition), test group and control group have five repetitions respectively, guarantee that as far as possible the existing test group of each part of animal house has control group again.Control group fed pig farm basal feed, test group add the pyrrolidine hydrochloride row ketone of 80mg/kg on the basis of pig farm basal feed, the record swinery search for food and the serum index (table 1 ~ 2) of swinery is measured in weightening finish situation and blood sampling.
Table 1 pyrrolidine hydrochloride row ketone is to the influence of fattening pig (50-70kg) growth performance in early stage
Table 2 pyrrolidine hydrochloride row ketone is to the influence of fattening pig middle and later periods (70-90kg) growth performance
1, to the influence of average daily gain
The first time tests the average daily gain test group and control group is more or less the same, and the weightening finish of 0 ~ 14d control group is high slightly, and the weightening finish of 14 ~ 28d test group is high slightly, and the full phase, test group is identical with the control group average daily gain; It is high by 6.72% to test for the second time full phase average daily gain test group contrast control group, and the average daily gain of each step-by-step test group all is higher than control group.The result shows that pyrrolidine hydrochloride row ketone does not influence the average daily gain of fattening pig in early stage, but can improve fattening phase middle and later periods pig average daily gain 51g/d.
2, to the influence of average daily ingestion amount
Testing for the first time average each stage of daily ingestion amount test group all will be lower than control group, and the average daily ingestion amount significant difference (P＜0.05) of full phase.The second time tests average daily ingestion amount test group of full phase and control group is more or less the same, and the daily ingestion amount of 0 ~ 14d control group is high slightly, and the daily ingestion amount of 14 ~ 28d test group is high slightly.The result shows that pyrrolidine hydrochloride row ketone can reduce the average daily ingestion amount 120.9g/d of fattening pig in early stage, but does not influence the average daily ingestion amount of fattening middle and later periods pig.
3, reduce the material anharmonic ratio
Test for the first time full phase material anharmonic ratio test group contrast control group and reduced by 5.13%; And the material anharmonic ratio test group in each stage all will be lower than control group, and having reduced the material anharmonic ratio under the situation of be more or less the same in weightening finish (differing 0.04%) mainly is because feed intake has descended.Test for the second time full phase material anharmonic ratio test group contrast control group and reduced by 5.52%.The result shows, from the whole fattening pig stage, adds pyrrolidine hydrochloride row ketone in the feed for reducing the material anharmonic ratio, and it is very resultful reducing feed cost.Though the fattening pig has all reduced more than 5% with fattening phase middle and later periods material anharmonic ratio early stage, there is notable difference in its mechanism of action, and fattening pig is because under the prerequisite that does not influence weightening finish in earlier stage, reduces food consumption and causes; The fattening pig middle and later periods is owing under the prerequisite that influences food consumption hardly, improve daily gain and realize.
Test shows, adds PIOGITAZONE HYDROCHLORIDE in the grow-finish pig feed, can improve the growth performance of pig, reduces the feed cost of per gain weight, promotes the healthy growth of swinery.
Embodiment 2 influences the serum biochemistry mechanism of production performance
For the serum glycolipid metabolism of observing pig and pig utilization rate to protein; The pig of choosing about average weight is individual; Each repeats to select 2 (each 10 of control group and test group), carries out the vena cava anterior blood drawing, centrifugation serum; Each item serum index is measured, comprised blood sugar, triglycerides, serum urea nitrogen and The Total albumen content (table 3 ~ 4).
Table 3 pyrrolidine hydrochloride row ketone is to the influence of fattening pig serum biochemistry index in early stage
Table 4 pyrrolidine hydrochloride row ketone is to the influence of fattening pig middle and later periods serum biochemistry index
Blood-sugar content and lipids contents test group and the control group of testing for the first time 14d, 28d all are more or less the same; And all be within the normal range (NR); The serum urea nitrogen control group all was higher than test group in 14d and 28d days; The serum urea nitrogen of 14d test group is lower by 34.45% than control group, and the serum urea nitrogen of 28d test group is than control group low 31.35%.This explanation pyrrolidine hydrochloride row ketone is all little to the glycolipid metabolism influence of the individual serum of healthy animal; But protein metabolism has been produced certain influence; The utilization rate of the decline explanation protein of serum urea nitrogen raises; This is consistent with the growth data result of front, infers that the synthetic increase of protein possibly be that the pig feed intake reduction does not but reduce the big main cause of average daily gain before the stage of fattening.
Blood-sugar content, serum urea nitrogen content test group and the control group of testing for the second time 14d, 28d all differ not quite, and the test group lipids contents is higher by 10% than control group, and blood sugar and lipids contents all are in the normal range (NR), are more or less the same on the whole.According to testing result, infer that pyrrolidine hydrochloride row ketone is little to serum glycometabolism and the protein utilization influence of fattening pig middle and later periods, possibly influence its fat metabolism.
This is very different with treatment diabetes clinical test results; The clinical research result shows; The type-II diabetes patient blood sugar and the lipids contents of taking pyrrolidine hydrochloride row ketone have all obtained tangible decline, and this result of the test shows that pyrrolidine hydrochloride row ketone produces obvious influence hardly to the animal individual blood sugar and the lipids contents of normal physiological status.
Embodiment 3 pyrrolidine hydrochloride row ketone are to the influence of meat quality and possible mechanism thereof
For the further influence of observing pyrrolidine hydrochloride row ketone additive to meat quality, and inquire into its possible mechanism of action.On June 28th, 2009; When for the second time feeding experiment finishes, select to be in 10 of pigs about average weight, each repeats one (respectively 5 of test group and control groups); Guangdong Province's herding in meat matter evaluation slaughter line carry out slaughter experiment, measure its carcass trait and meat matter proterties; And carrying out the sample collection, research pyrrolidine hydrochloride row ketone influences the mechanism of meat matter.
Table 5 pyrrolidine hydrochloride row ketone is to the influence of fattening pig middle and later periods carcass trait and meat matter
1, to the influence of carcass trait
The test group thickness of backfat reduces by 5.07% than control group; The dressing percentage of test group is higher by 1.21% than control group.That is to say that pyrrolidine hydrochloride row ketone can reduce the thickness of backfat (relevant with lean meat percentage) and increase dressing percentage.
2, improve meat matter
In several indexs of definition meat matter, the drip loss of test group meat sample, yellowish pink scoring and marble grain scoring all are better than control group, and the drip loss test group is than control group low 11.03%.All within normal yellowish pink scope, the test group mark is higher by 7.89% than control group for yellowish pink scoring test group and control group; With chromascope to yellowish pink a value measure; A value and b/a value are all represented yellowish pink scarlet degree, are also representing intramuscular pigment content, and a value is directly proportional with yellowish pink scarlet degree; And the b/a value is inversely proportional to yellowish pink scarlet degree; The a value of test group is higher by 6.42% than control group, and the b/a value of test group is littler by 10.00% than the b/a value of control group, and this explanation test group meat appearance color has scarlet trend.What the marble grain scoring was showed is the content of fat between intramuscular fat and flesh; The marbled degree of depth and intramuscular fat are proportionate; Kind is careful more; The ratio of invisible intramuscular fat is big more in the more high-grade pork of meat, and is higher by 32.18% than control group through the marble grain scoring of qualification test group.These data show that test group meat sample matter is better than control group.Again test group and control group longissimus dorsi muscle slaughter meat appearance have been carried out intramuscular fat mensuration subsequently; The result is that the intramuscular fat content of test group longissimus dorsi muscle exceeds control group 17%; Intramuscular fat content has the trend of obvious increase, matches with the marble grain appraisal result.Comprehensive drip loss, yellowish pink, marble grain, intramuscular fat content etc. influence the index of meat merit, add pyrrolidine hydrochloride row ketone in the feed meat tool is improved significantly.
Embodiment 4 pyrrolidine hydrochloride row ketone are to the influence of glycolipid metabolism in the muscle
GLUT4 is the glucose transport factor 4; Mainly be present in the muscle; The effect of its expression is the transhipment of participating in glucose in the body; One of insulin resistance characteristic of diabetes B patient is exactly expression and the transposition obstacle of GLUT4, and clinical testing shows that the expression of the patient GLUT4 that has taken pyrrolidine hydrochloride row ketone obviously increases; FABP3 is a fatty acid binding protein, participates in the transportation of aliphatic acid, is the important factor of fat deposition.
Increase the molecular mechanism of intramuscular fat content for further studying pyrrolidine hydrochloride row ketone; RNA to pig longissimus dorsi muscle sample has carried out extracting; Reverse transcription becomes cDNA; As internal standard gene, GLUT4 gene and FABP3 gene are carried out real-time fluorescence quantitative RT-PCR mensuration with GADPH, observe their relative expression quantity.The result shows (Fig. 1), and the FABP3 that participates in fat transfer expresses obviously and increases, and the relative expression quantity of the FABP3 gene of test group is higher by 65.12% than control group; And the relative expression quantity test group and the control group of participating in the GLUT4 of musculature glucose transport are more or less the same.Prompting pyrrolidine hydrochloride row ketone maybe be through increasing the expression of FABP3, thereby increase the synthetic of aliphatic acid in the muscle, finally shows as the raising intramuscular fat content, increases marble grain.And pyrrolidine hydrochloride row ketone is expressed influence not quite to muscle glucose transport carrier GLUT4, in conjunction with serological index, can judge that basically pyrrolidine hydrochloride row ketone does not have influence basically to the individual glycometabolism of health pig.
Embodiment 5 oil red O stain frozen sections are observed the general distribution situation of intramuscular fat
For the superficial appearance of viewing test group and control group intramuscular fat, the longissimus dorsi muscle sample of gathering has been processed frozen section, and frozen section has been carried out oil red O stain.Oil red O stain is a kind of colouring method that fat is identified, dyestuff mainly is oil red and haematoxylin.At first section is dyeed, the fat in the sample is dyed redness, use the nuclear staining of haematoxylin pair cell again, make the monoblock section be easier to observe, the fat of being dyed redness that microscopically is mainly observed with oil red.That Fig. 2 shows is test group and the representational oil red stained of control group pig longissimus dorsi muscle figure (100 *); From figure, can see; The fatty oil droplet that is colored in the test group muscle samples longer thicker (redness); Area occupied is bigger, and this can be from the situation of side reflection test group intramuscular fat content increase.
Claims (1)
1. the application of PIOGITAZONE HYDROCHLORIDE in pig feed additive is characterized in that the addition of said PIOGITAZONE HYDROCHLORIDE in feed is 50～100g/t.
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| CN106819488A (en) * | 2017-03-16 | 2017-06-13 | 华南农业大学 | The application of PIOGITAZONE HYDROCHLORIDE and lysine in terms of pig feed additive is fattened |
| CN107125473A (en) * | 2017-06-01 | 2017-09-05 | 华南农业大学 | The application of PIOGITAZONE HYDROCHLORIDE and vitamin E in terms of pig feed additive is fattened |
| CN107183358A (en) * | 2017-06-01 | 2017-09-22 | 华南农业大学 | The application of PIOGITAZONE HYDROCHLORIDE and chromium methionine in terms of pig feed additive is fattened |
| CN110679773A (en) * | 2019-10-31 | 2020-01-14 | 华南农业大学 | Application of pioglitazone hydrochloride and L-carnosine in preparation of chicken feed or additive thereof |
| CN110679774A (en) * | 2019-10-31 | 2020-01-14 | 华南农业大学 | Application of pioglitazone hydrochloride and resveratrol in preparing chicken feed |
Citations (4)
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| WO2006009149A1 (en) * | 2004-07-21 | 2006-01-26 | Kissei Pharmaceutical Co., Ltd. | Progression inhibitor for disease attributed to abnormal accumulation of liver fat |
| WO2006022428A1 (en) * | 2004-08-26 | 2006-03-02 | Takeda Pharmaceutical Company Limited | Remedy for diabetes |
| CN1857264A (en) * | 2006-04-14 | 2006-11-08 | 北京润德康医药技术有限公司 | Medicine composition with pioglitazone hydrochloride and glimepiride as active components and its preparing method and use |
| CN101219122A (en) * | 2007-12-28 | 2008-07-16 | 江苏万邦生化医药股份有限公司 | Hydrochloric acid glitazone dispersion piece and its preparation method |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006009149A1 (en) * | 2004-07-21 | 2006-01-26 | Kissei Pharmaceutical Co., Ltd. | Progression inhibitor for disease attributed to abnormal accumulation of liver fat |
| WO2006022428A1 (en) * | 2004-08-26 | 2006-03-02 | Takeda Pharmaceutical Company Limited | Remedy for diabetes |
| CN1857264A (en) * | 2006-04-14 | 2006-11-08 | 北京润德康医药技术有限公司 | Medicine composition with pioglitazone hydrochloride and glimepiride as active components and its preparing method and use |
| CN101219122A (en) * | 2007-12-28 | 2008-07-16 | 江苏万邦生化医药股份有限公司 | Hydrochloric acid glitazone dispersion piece and its preparation method |
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