CN101884638A - 5α-雄甾(烷)-3β,5,6β-三醇在制备神经元保护药物中的应用 - Google Patents
5α-雄甾(烷)-3β,5,6β-三醇在制备神经元保护药物中的应用 Download PDFInfo
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- CN101884638A CN101884638A CN2010102241733A CN201010224173A CN101884638A CN 101884638 A CN101884638 A CN 101884638A CN 2010102241733 A CN2010102241733 A CN 2010102241733A CN 201010224173 A CN201010224173 A CN 201010224173A CN 101884638 A CN101884638 A CN 101884638A
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- A61K31/00—Medicinal preparations containing organic active ingredients
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- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
Abstract
Description
Claims (4)
Priority Applications (22)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2010102241733A CN101884638B (zh) | 2010-07-09 | 2010-07-09 | 5α-雄甾(烷)-3β,5,6β-三醇在制备神经元保护药物中的应用 |
HUE11803155A HUE032159T2 (en) | 2010-07-09 | 2011-07-08 | The use of 5-alpha-androstane-3β, 5,6ß-triol in the manufacture of neuroprotective drugs |
RS20170319A RS55845B1 (sr) | 2010-07-09 | 2011-07-08 | Upotreba 5-androstan (alkil)-3,5,6 -triola u pripremanju neuroprotektivnih lekova |
AU2011276800A AU2011276800B2 (en) | 2010-07-09 | 2011-07-08 | Use of 5a-androstane (alkyl)-3B,5,6B-triol in preparing neuroprotective drugs |
RU2012151400/15A RU2541093C2 (ru) | 2010-07-09 | 2011-07-08 | Применение 5а-андростан-3в,5,6в-триола для изготовления нейропротекторных лекарственных средств |
KR1020127032524A KR101463477B1 (ko) | 2010-07-09 | 2011-07-08 | 5a-안드로스탄(알킬)-3β,5,6β-트리올의 신경보호 약물 제조에서의 용도 |
DK11803155.8T DK2591785T3 (en) | 2010-07-09 | 2011-07-08 | USE OF 5-ANDROSTANE (ALKYL) -3,5,6-TRIOL FOR THE PREPARATION OF NEURO PROTECTIVE MEDICINE |
ES11803155.8T ES2620754T3 (es) | 2010-07-09 | 2011-07-08 | Uso de 5-androstano (alquil)-3,5,6-triol en la preparación de fármacos neuroprotectores |
PL11803155T PL2591785T3 (pl) | 2010-07-09 | 2011-07-08 | Zastosowanie 5-androstano(alkilo)-3,5,6-triolu do wytwarzania leków neuroprotekcyjnych |
JP2013516989A JP5681931B2 (ja) | 2010-07-09 | 2011-07-08 | ニューロン保護薬の製造のための5α−アンドロスタン−3β,5,6β−トリオールの使用 |
BR112012031861A BR112012031861B1 (pt) | 2010-07-09 | 2011-07-08 | uso de 5a-androstano-3ß,5,6ß-triol |
US13/805,436 US8809309B2 (en) | 2010-07-09 | 2011-07-08 | Use of 5α-androstane (alkyl)-3β,5,6β-triol in preparation of neuroprotective drugs |
EP11803155.8A EP2591785B1 (en) | 2010-07-09 | 2011-07-08 | Use of 5-androstane (alkyl)-3,5,6 -triol in preparing neuroprotective drugs |
PCT/CN2011/076967 WO2012003802A1 (zh) | 2010-07-09 | 2011-07-08 | 5α-雄甾(烷)-3β,5,6β-三醇在制备神经元保护药物中的应用 |
CA2802133A CA2802133C (en) | 2010-07-09 | 2011-07-08 | Use of 5.alpha.-androstane(alkyl)-3.beta.,5,6.beta.-triol in preparation of neuroprotective drugs |
PT118031558T PT2591785T (pt) | 2010-07-09 | 2011-07-08 | Utilização de 5-androstano(alquilo)-3,5,6-triol na preparação de fármacos neuroprotetores |
LTEP11803155.8T LT2591785T (lt) | 2010-07-09 | 2011-07-08 | 5-androstan(alkil)-3,5,6-triolio panaudojimas neuroprotekcinių vaistų gamybai |
SG2012088688A SG186135A1 (en) | 2010-07-09 | 2011-07-08 | Use of 5a-androstane (alkyl)-3b,5,6b-triol in preparing neuroprotective drugs |
SI201131126A SI2591785T1 (sl) | 2010-07-09 | 2011-07-08 | Uporaba 5-androstan(alkil)-3,5,6-triola pri pripravi nevroprotektivnega zdravila |
US14/332,338 US9320743B2 (en) | 2010-07-09 | 2014-07-15 | Use of 5α-androstane-3β,5,6β-triol in preparation of neuroprotective drugs |
HRP20170418TT HRP20170418T1 (hr) | 2010-07-09 | 2017-03-14 | Uporaba 5-androstan (alkil)-3,5,6-triola u pripravi neuroprotektivnih lijekova |
CY20171100375T CY1118789T1 (el) | 2010-07-09 | 2017-03-27 | Χρηση 5α-ανδροστανο(αλκυλο)-3β,5-6β-τριολης σε παρασκευη νευροπροστατευτικων φαρμακων |
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WO2012003802A1 (zh) * | 2010-07-09 | 2012-01-12 | 中山大学 | 5α-雄甾(烷)-3β,5,6β-三醇在制备神经元保护药物中的应用 |
CN102617685A (zh) * | 2012-03-08 | 2012-08-01 | 广州市赛普特医药科技有限公司 | 雄甾-3β,5α,6β-三醇的晶型化合物及其制备方法 |
JP2013537170A (ja) * | 2010-09-21 | 2013-09-30 | グァンチョウ セルプロテック ファーマシューティカル リミテッド | 5α−アンドロスタン−3β,5,6β−トリオール注射剤及びその調製方法 |
WO2015161747A1 (zh) * | 2014-04-25 | 2015-10-29 | 广州市赛普特医药科技有限公司 | 神经保护剂及其适应症 |
RU2629929C2 (ru) * | 2013-03-28 | 2017-09-05 | Гуанчжоу Селлпротек Фармасьютикал Ко., Лтд | 2β,3α,5α-ТРИГИДРОКСИ-АНДРОСТ-6-ОН, СПОСОБЫ ЕГО ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ |
WO2019129181A1 (zh) * | 2017-12-29 | 2019-07-04 | 广州市赛普特医药科技股份有限公司 | 化合物在制备治疗出血性脑卒中药物中的应用 |
WO2019129179A1 (zh) * | 2017-12-29 | 2019-07-04 | 广州市赛普特医药科技股份有限公司 | 化合物在制备治疗脑小血管病的药物中的应用 |
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JP2013537170A (ja) * | 2010-09-21 | 2013-09-30 | グァンチョウ セルプロテック ファーマシューティカル リミテッド | 5α−アンドロスタン−3β,5,6β−トリオール注射剤及びその調製方法 |
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RU2012151400A (ru) | 2014-08-20 |
PL2591785T3 (pl) | 2017-08-31 |
CA2802133C (en) | 2014-01-14 |
RU2541093C2 (ru) | 2015-02-10 |
RS55845B1 (sr) | 2017-08-31 |
ES2620754T3 (es) | 2017-06-29 |
LT2591785T (lt) | 2017-06-26 |
HUE032159T2 (en) | 2017-09-28 |
AU2011276800A1 (en) | 2013-01-10 |
HRP20170418T1 (hr) | 2017-06-16 |
JP5681931B2 (ja) | 2015-03-11 |
EP2591785B1 (en) | 2017-01-04 |
KR20130038286A (ko) | 2013-04-17 |
AU2011276800A9 (en) | 2013-11-21 |
CY1118789T1 (el) | 2018-03-07 |
BR112012031861A2 (pt) | 2016-11-08 |
PT2591785T (pt) | 2017-04-04 |
JP2013529657A (ja) | 2013-07-22 |
SG186135A1 (en) | 2013-01-30 |
AU2011276800B2 (en) | 2013-11-21 |
CA2802133A1 (en) | 2012-01-12 |
WO2012003802A1 (zh) | 2012-01-12 |
KR101463477B1 (ko) | 2014-11-19 |
SI2591785T1 (sl) | 2017-07-31 |
CN101884638B (zh) | 2011-11-09 |
US20130157993A1 (en) | 2013-06-20 |
EP2591785A1 (en) | 2013-05-15 |
BR112012031861B1 (pt) | 2020-02-04 |
EP2591785A4 (en) | 2013-12-11 |
US20140329790A1 (en) | 2014-11-06 |
DK2591785T3 (en) | 2017-03-27 |
US9320743B2 (en) | 2016-04-26 |
US8809309B2 (en) | 2014-08-19 |
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Address after: Moon Road, Science City high tech Industrial Development Zone of Guangzhou City, Guangdong province 510663 No. 3 Guangzhou international business incubator C District No. G401-415 room Patentee after: GUANGZHOU SAIPUTE PHARMACEUTICAL TECHNOLOGY CO., LTD. Address before: Guangzhou Science City skim Springs Road No. 3, Guangzhou international business incubator C208 Patentee before: Guangzhou Saipute Medical Technology Co., Ltd. |