CN101884334A - Amistar and thiophanate methyl-containing bactericide composition - Google Patents
Amistar and thiophanate methyl-containing bactericide composition Download PDFInfo
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- CN101884334A CN101884334A CN2010101505113A CN201010150511A CN101884334A CN 101884334 A CN101884334 A CN 101884334A CN 2010101505113 A CN2010101505113 A CN 2010101505113A CN 201010150511 A CN201010150511 A CN 201010150511A CN 101884334 A CN101884334 A CN 101884334A
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- thiophanate
- methyl
- fluoxastrobin
- suspending agent
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Abstract
The invention relates to a bactericide composition with synergistic action. The effective active ingredients of the bactericide composition contain amistar and thiophanate in a weight ratio of 2:1-1:8. Added with an auxiliary agent and an excipient, the effective active ingredients can be prepared into a suspension and a microcapsule suspension. The bactericide composition is mainly used for preventing and treating powdery mildew, anthracnose, alternaria leaf spot, rust disease and rice blast.
Description
Technical field
The invention belongs to technical field of pesticide, relate to a kind of application of bactericidal composition on fruit diseases that contains Fluoxastrobin and thiophanate-methyl.
Technical background
Fluoxastrobin (azoxystrobin) is the heterocyclic nitrogen-group fungicide of Britain ICI company exploitation.Molecular formula: C24H17N3O5, chemical name: (E)-and 2-{2-[6 (2-cyano-benzene oxygen) pyrimidine-4-base oxygen] phenyl }-the 3-methoxy acrylate.
Fluoxastrobin belongs to the mitochondrial respiratory inhibitor, promptly passes through to shift to the electronics of cromoci at cytochrome B cl, thereby suppresses mitochondrial breathing.The bacterial strain that 14-demethylation enzyme inhibitor, benzamides, dicarboxylic dihydrazides amine and benzimidazole is produced resistance is effective.Have protection, root out, infiltration, systemic activity.Suppress spore germination and mycelial growth and produce spore always.
Thiophanate-methyl (thiophanate-methyl) belongs to benzimidazole, and molecular formula is (C
12H
14N
4S
2O
4), chemical name: 1,2-two (3-methoxycarbonyl group-2-ghiourea group) benzene.
Thiophanate-methyl belongs to benzimidazole, is a kind of broad spectrum activity systemic fungicide, can prevent and treat the various crop disease, has interior suction, prevention and therapeutic action.It is converted into carbendazim in plant corpus, disturb the formation of spindle in the germ mitosis, influences cell division.
No matter be Fluoxastrobin, thiophanate-methyl or other efficient germicides, long-term use separately makes disease develop immunity to drugs easily, causes the problem that dosage strengthens, preventive effect reduces, the lasting period shortens, and is unfavorable for environment sustainable development.The active ingredient of the different mechanisms of action is carried out composite, is to delay the disease method commonly used that develops immunity to drugs, and according to the effect in the production application, judge this composite be synergistic effect or antagonism.Complex role is more significantly filled a prescription, and can obviously improve preventive effect, reduces the dosage of agricultural chemicals greatly, also can enlarge fungicidal spectrum, improves germicidal efficiency.Fluoxastrobin is different with the thiophanate-methyl mechanism of action, and mutually composite have good synergistic effect within the specific limits.And composite about Fluoxastrobin and thiophanate-methyl do not see relevant report at present at home and abroad as yet.
Summary of the invention
The objective of the invention is to propose a kind of have synergistic function, use cost is low, preventive effect the is good bactericidal composition that contains Fluoxastrobin and thiophanate-methyl.
The present invention is achieved through the following technical solutions:
A kind of bactericidal composition that contains Fluoxastrobin and thiophanate-methyl, wherein Fluoxastrobin and thiophanate-methyl weight ratio are 2: 1～1: 8.
The described bactericidal composition that contains Fluoxastrobin and thiophanate-methyl, wherein the weight ratio of Fluoxastrobin and thiophanate-methyl is 1: 1～1: 5.
The described bactericidal composition that contains Fluoxastrobin and thiophanate-methyl, wherein the weight ratio of Fluoxastrobin and thiophanate-methyl is 1: 3～1: 5.
The described bactericidal composition of Fluoxastrobin and thiophanate-methyl that contains is by technology well-known in the art, add conventional auxiliary agent and can be made into wetting powder, water dispersible granules, suspending agent, microcapsule suspending agent, aqueous emulsion, microemulsion, missible oil, wherein be preferably suspending agent, microcapsule suspending agent.
Composition of the present invention is mainly used in prevents and treats powdery mildew, anthracnose, spot fallen leaves, rust and rice blast.
Beneficial effect of the present invention: (1) present composition effective active composition Fluoxastrobin and thiophanate-methyl belong to the bactericide of two kinds of different mechanisms of action, and both are mixed mutually and can produce conflict; (2) present composition has good synergistic effect within the specific limits, and preventive effect is higher than single agent, and dosage is little; (3) the present invention is with an organic solvent few, is difficult for producing poisoning, is convenient to transportation and storage; (4) present composition has special efficacy to powdery mildew, anthracnose, spot fallen leaves, rust and rice blast.
Embodiment
To further instruction of the present invention, the percentage among the embodiment all is weight percentage below in conjunction with embodiment, but the present invention is not limited thereto.
The embodiment of the invention is the method that adopts Toxicity Determination and field trial to combine.Pass through Toxicity Determination earlier, the synergy ratio (SR) after clear and definite two kinds of medicaments are composite by a certain percentage, SR＜0.5 is an antagonism, and 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect, on this basis, carry out field trial again.
Implementation of an application example one the implementation of Formulation Example
Embodiment 150% Fluoxastrobin thiophanate-methyl suspending agent
Fluoxastrobin 10%, thiophanate-methyl 40%, alkyl benzene sulfonate calcium salt 4%, sodium lignin sulfonate 3%, DBSA 4%, silicone oil 0.1%, xanthan gum 0.3%, deionized water adds to 100%, the mixed 50% Fluoxastrobin thiophanate-methyl suspending agent that gets.
Embodiment 235% Fluoxastrobin thiophanate-methyl suspending agent
Fluoxastrobin 5%, thiophanate-methyl 30%, polycarboxylate 4%, soapberry powder 5%, silicone compound 0.1%, hydroxyethylcellulose 0.1%, ethylene glycol 2%, deionized water add to 100%, the mixed 35% Fluoxastrobin thiophanate-methyl suspending agent that gets.
Embodiment 330% Fluoxastrobin thiophanate-methyl suspending agent
Fluoxastrobin 10%, thiophanate-methyl 20%, polyoxyethylene carboxylate 4%, spaonin powder 5%, silicone compound 0.1%, polyvinyl alcohol 0.4%, propane diols 2%, deionized water add to 100%, the mixed 30% Fluoxastrobin thiophanate-methyl suspending agent that gets.
Embodiment 418% Fluoxastrobin thiophanate-methyl suspending agent
Fluoxastrobin 2%, thiophanate-methyl 16%, polycarboxylate 2%, neopelex 2%, silicone compound 0.1%, polyethylene glycol 0.5%, glycerine 4%, deionized water add to 100%, the mixed 18% Fluoxastrobin thiophanate-methyl suspending agent that gets.
Embodiment 548% Fluoxastrobin thiophanate-methyl microcapsule suspending agent
Fluoxastrobin 8%, thiophanate-methyl 40%, sorbitol monooleate 8%, triphenyl vinyl phenol polyoxyethylene poly-oxygen propylene aether 5%, gelatin 10% dimethylbenzene 8%, dimethyl sulfoxide (DMSO) 5%, deionized water add to 100%, the mixed 48% Fluoxastrobin thiophanate-methyl microcapsule suspending agent that gets.
Embodiment 640% Fluoxastrobin thiophanate-methyl microcapsule suspending agent
Fluoxastrobin 10%, thiophanate-methyl 30%, farming breast 400
#8%, 600
#Phosphate 5%, shitosan 10%, acetone 8%, cyclohexanone 5%, deionized water add to 100%, the mixed 40% Fluoxastrobin thiophanate-methyl microcapsule suspending agent that gets.
Embodiment 730% Fluoxastrobin thiophanate-methyl microcapsule suspending agent
Fluoxastrobin 20%, thiophanate-methyl 10%, sorbitol monooleate 8%, OP series 5%, sodium lignin sulfonate 10%, acetone 8%, acetonitrile 5%, deionized water add to 100%, the mixed 30% Fluoxastrobin thiophanate-methyl microcapsule suspending agent that gets.
Embodiment 810% Fluoxastrobin thiophanate-methyl microcapsule suspending agent
Fluoxastrobin 5%, thiophanate-methyl 5%, farming breast 400
#8%, the farming breast 600
#5%, melamine resin 8%, dimethylbenzene 5%, dimethyl sulfoxide (DMSO) 5%, deionized water add to 100%, the mixed 10% Fluoxastrobin thiophanate-methyl microcapsule suspending agent that gets.
Implementation of an application example two: Fluoxastrobin and thiophanate-methyl are composite to be provided by Shaanxi agricultural chemicals Co., Ltd of U.S. nation powdery mildew of cucumber Toxicity Determination test medicine.
After the effective inhibition concentration scope of each medicament was determined in prerun, each medicament was established 5 dosage respectively by active constituent content and is handled, and established the clear water contrast.Carry out with reference to " agricultural chemicals indoor bioassay test rule bactericide ", adopt the mycelial growth rate method to measure the virulence of medicament powdery mildew of cucumber.Measure colony diameter with the right-angled intersection method behind the 72h, calculate and respectively handle clean amount of growth, mycelial growth inhibition rate.
Clean amount of growth (mm)=measurement colony diameter-5
Mycelial growth inhibition rate is converted into probit value (y), and liquor strength (μ g/mL) converts logarithm value (x) to, tries to achieve virulence regression equation (y=a+bx) with method of least squares, and calculates the EC of every kind of medicament thus
50Value.Calculate the different proportioning synergy ratios (SR) of two medicaments according to the Wadley method simultaneously, SR＜0.5 is an antagonism, and 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect.Computing formula is as follows:
Wherein: a, b are respectively Fluoxastrobin and thiophanate-methyl shared ratio in combination
A is a Fluoxastrobin
B is a thiophanate-methyl
Result of the test is as shown in table 1:
Table 1 Fluoxastrobin, thiophanate-methyl and composite toxicity test analysis of results table thereof to powdery mildew of cucumber
As shown in Table 1, Fluoxastrobin, thiophanate-methyl are to the EC of powdery mildew of cucumber
50Be respectively 2.41mg/L and 8.95mg/L.The virulence of Fluoxastrobin is higher than the virulence of thiophanate-methyl.2: 1,1: 1,1: 2,1: 4,1: 8 synergy ratio of Fluoxastrobin and thiophanate-methyl proportioning is respectively 1.59,1.75,2.12,1.82,1.52, illustrating that Fluoxastrobin and thiophanate-methyl were mixed in the scope at 2: 1～1: 8 all shows obvious synergistic effect, synergy ratio SR maximum when Fluoxastrobin and thiophanate-methyl weight ratio are 1: 2 wherein, synergistic effect is the most obvious.
Embodiment uses three Fluoxastrobins and the thiophanate-methyl and the composite powdery mildew of cucumber test of pesticide effectiveness of preventing and treating thereof
This experimental establishment is at the Xian District, Shanxi Province suburban area, and test medicine is researched and developed, provided by Shaanxi agricultural chemicals Co., Ltd of U.S. nation, contrast medicament 70% thiophanate-methyl wetting powder (commercial), 50% azoxystrobin water dispersible granule (commercial).
Investigate before the dispenser for the first time and calculate the powdery mildew of cucumber disease index, dispenser for the second time after 7 days, dispenser is 2 times altogether, investigates disease indexs in 7 days, 15 days after the dispenser for the second time and calculates preventive effect.
Experimental result is as follows:
Table 2 Fluoxastrobin, thiophanate-methyl and the composite powdery mildew of cucumber test of pesticide effectiveness of preventing and treating thereof
As can be seen from Table 2, can effectively prevent and treat powdery mildew of cucumber after Fluoxastrobin and thiophanate-methyl are composite, control efficiency all is better than contrasting medicament, and the lasting period is long.In the test scope of medication, the target crop is had no adverse effects, and cucumber anthracnose is had preventive effect preferably.
Implementation of an application example four: Fluoxastrobin and thiophanate-methyl and the composite wheat rust test of pesticide effectiveness of preventing and treating thereof
This experimental establishment is in the Lingbi County, Jiangxi Province, and test medicine is researched and developed, provided by Shaanxi agricultural chemicals Co., Ltd of U.S. nation, contrast medicament 70% thiophanate-methyl wetting powder (commercial), 50% azoxystrobin water dispersible granule (commercial).
The investigation wheat rust state of an illness before the medicine, in their early stage dispenser for the first time, dispenser in per 7 days once is total to dispenser 3 times.Investigated the wheat rust disease index respectively and calculated preventive effect in 7 days, 14 days after the dispenser for the third time.Experimental result is as follows:
Table 3 Fluoxastrobin, thiophanate-methyl and the composite wheat rust test of pesticide effectiveness of preventing and treating thereof
| Handle medicament | The preparation dosage | 7 days preventive effects (%) behind the last medicine | 14 days preventive effects (%) behind the last medicine | 30 days preventive effects (%) behind the last medicine |
| 35% Fluoxastrobin thiophanate-methyl suspending agent | 60 gram/mus | ??84.16 | ??93.05 | ??92.44 |
| 30% Fluoxastrobin thiophanate-methyl microcapsule suspending agent | 65 gram/mus | ??88.74 | ??94.26 | ??93.69 |
| 70% thiophanate-methyl wetting powder | 110 gram/mus | ??57.24 | ??64.20 | ??57.38 |
| 50% azoxystrobin water dispersible granule | 40 gram/mus | ??75.36 | ??77.42 | ??62.42 |
As can be seen from Table 3, energy effectively preventing wheat rust after Fluoxastrobin and thiophanate-methyl are composite, control efficiency all is better than contrasting medicament, and dosage is little, and the lasting period is long.In the test scope of medication, the target crop there is not harm.
Implementation of an application example five: Fluoxastrobin, thiophanate-methyl and the composite control rice blast test of pesticide effectiveness thereof
This experimental establishment is in Hanzhong City suburb, Shaanxi Province, and test medicine is researched and developed, provided by Shaanxi agricultural chemicals Co., Ltd of U.S. nation, contrast medicament 70% thiophanate-methyl wetting powder (commercial), 50% azoxystrobin water dispersible granule (commercial).
Investigation state of an illness radix, total number of sheets, the sick number of sheets and sick leaf-size class number before the medicine, in the their early stage dispenser, dispenser in per 7 days once is total to dispenser 2 times, investigates disease index respectively and calculates preventive effect in 7 days, 14 days after the dispenser for the second time.Experimental result is as follows:
Table 4 Fluoxastrobin, thiophanate-methyl and the composite control rice blast test of pesticide effectiveness thereof
| Handle medicament | The preparation dosage | 7 days preventive effects (%) behind the medicine for the third time | 14 days preventive effects (%) behind the medicine for the third time |
| 30% Fluoxastrobin thiophanate-methyl suspending agent | 60 gram/mus | ?89.72 | ??88.08 |
| 10% Fluoxastrobin thiophanate-methyl microcapsule suspending agent | 150 gram/mus | ?90.16 | ??91.32 |
| 70% thiophanate-methyl wetting powder | 110 gram/mus | ?53.44 | ??66.34 |
| 50% azoxystrobin water dispersible granule | 40 gram/mus | ?67.28 | ??73.45 |
As can be seen from Table 4, can effectively prevent and treat rice blast after Fluoxastrobin and thiophanate-methyl are composite and take place, control efficiency all is better than contrasting medicament, in this test scope of medication the target crop is had no adverse effects.
Implementation of an application example six: Fluoxastrobin and thiophanate-methyl and the composite control apple spot fallen leaves test of pesticide effectiveness thereof
This experimental establishment is in area just outside a city gate town, Pucheng County, Shaanxi Province, and test medicine is researched and developed, provided by Shaanxi agricultural chemicals Co., Ltd of U.S. nation, contrast medicament 70% thiophanate-methyl wetting powder (commercial), 50% azoxystrobin water dispersible granule (commercial).
In the dispenser of apple their early stage, dispenser in per 7 days once, altogether dispenser is 3 times, investigation disease index before the dispenser was investigated disease index respectively in 7 days, 15 days after the dispenser for the third time, and the calculation correction preventive effect, result of the test is as follows:
Table 5 Fluoxastrobin and thiophanate-methyl and the composite control apple spot fallen leaves test of pesticide effectiveness thereof
| Handle medicament | The preparation dosage | 7 days preventive effects (%) behind the medicine for the third time | 15 days preventive effects (%) behind the medicine for the third time |
| 18% Fluoxastrobin thiophanate-methyl suspending agent | 100 gram/mus | ??89.63 | ??94.76 |
| 48% Fluoxastrobin thiophanate-methyl microcapsule suspending agent | 40 gram/mus | ??90.56 | ??95.37 |
| 70% thiophanate-methyl wetting powder | 110 gram/mus | ??63.36 | ??72.17 |
| 50% azoxystrobin water dispersible granule | 40 gram/mus | ??79.77 | ??83.36 |
As can be seen from Table 5, Fluoxastrobin, thiophanate-methyl can be fallen leaves by effectively preventing apple spot, and control efficiency all is better than contrasting medicament, and dosage is little, in the test scope of medication target crop is not had harm.
Claims (5)
1. bactericidal composition that contains Fluoxastrobin and thiophanate-methyl, the weight ratio that it is characterized in that microbicide compositions effective active composition Fluoxastrobin and thiophanate-methyl is 2: 1～1: 8.
2. the bactericidal composition that contains Fluoxastrobin and thiophanate-methyl according to claim 1 is characterized in that: wherein the weight ratio of Fluoxastrobin and thiophanate-methyl is 1: 1～1: 5.
3. the bactericidal composition that contains Fluoxastrobin and thiophanate-methyl according to claim 2 is characterized in that: wherein the weight ratio of Fluoxastrobin and thiophanate-methyl is 1: 3～1: 5.
4. the bactericidal composition that contains Fluoxastrobin and thiophanate-methyl according to claim 1 is characterized in that: microbicide compositions is made suspending agent, microcapsule suspending agent.
5. the bactericidal composition that contains Fluoxastrobin and thiophanate-methyl according to claim 1 is used to prevent and treat powdery mildew, anthracnose, spot fallen leaves, rust and rice blast.
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| CN1930983A (en) * | 2005-09-15 | 2007-03-21 | 南京第一农药有限公司 | Germicide composition containing azoxystrobin and thiophanate-methyl and its application |
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|---|---|---|---|---|
| CN1930983A (en) * | 2005-09-15 | 2007-03-21 | 南京第一农药有限公司 | Germicide composition containing azoxystrobin and thiophanate-methyl and its application |
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Address after: 715500 Weinan City, Shaanxi province Pucheng County agricultural base industrial park Applicant after: Shaanxi Meibang Pesticide Co., Ltd. Address before: 710075, Xi'an high tech Zone, Shaanxi hi tech Zone, Jinqiao International C block, 15 Floor Applicant before: Shaanxi Meibang Pesticide Co., Ltd. |
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Application publication date: 20101117 |
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