CN101880694B - 一种非水相制备手性3r,5s-双羟基化合物的方法 - Google Patents
一种非水相制备手性3r,5s-双羟基化合物的方法 Download PDFInfo
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- CN101880694B CN101880694B CN200910232080.2A CN200910232080A CN101880694B CN 101880694 B CN101880694 B CN 101880694B CN 200910232080 A CN200910232080 A CN 200910232080A CN 101880694 B CN101880694 B CN 101880694B
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- benzyloxy
- substrate
- ethyl hexanoate
- dihydroxyl
- dihydroxyl compound
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Classifications
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- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/42—Hydroxy-carboxylic acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
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CN200910232080.2A CN101880694B (zh) | 2009-12-01 | 2009-12-01 | 一种非水相制备手性3r,5s-双羟基化合物的方法 |
PCT/CN2010/076242 WO2011066755A1 (zh) | 2009-12-01 | 2010-08-23 | (3r,5s)-二羟基-6-苄氧基己酸乙酯的合成 |
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CN103966176B (zh) | 2014-05-09 | 2017-12-22 | 凯莱英医药集团(天津)股份有限公司 | 双羰基还原酶突变体及其应用 |
CN109468347A (zh) * | 2018-08-30 | 2019-03-15 | 湖南师范大学 | 生物催化合成光学活性2r-氟代羧酸和2r-羟基羧酸的方法 |
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US5324662A (en) * | 1992-05-15 | 1994-06-28 | E. R. Squibb & Sons, Inc. | Stereoselective microbial or enzymatic reduction of 3,5-dioxo esters to 3-hydroxy-5-oxo, 3-oxo-5-hydroxy, and 3,5-dihydroxy esters |
CN101429514A (zh) * | 2007-11-08 | 2009-05-13 | 陈依军 | 一种双羰基还原酶、其基因及其应用 |
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US5324662A (en) * | 1992-05-15 | 1994-06-28 | E. R. Squibb & Sons, Inc. | Stereoselective microbial or enzymatic reduction of 3,5-dioxo esters to 3-hydroxy-5-oxo, 3-oxo-5-hydroxy, and 3,5-dihydroxy esters |
CN101429514A (zh) * | 2007-11-08 | 2009-05-13 | 陈依军 | 一种双羰基还原酶、其基因及其应用 |
Non-Patent Citations (2)
Title |
---|
Steven Goldberg等.Synthesis of ethyl-(3R,5S)-dihydroxy-6-benzyloxyhexanoates via diastereo- and enantioselective microbial reduction:Cloning and expression of ketoreductase III from Acinetobacter sp.SC 13874.《Enzyme and Microbial Technology》.2008,第43卷544–549. * |
姚鹏等.非水相中的酶催化.《化工进展》.1998,第1998年卷(第6期),1-4. * |
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