CN101869470B - Method for detecting cardiovascular and cerebrovascular diseases based on blood pressure factor combination and device thereof - Google Patents

Abstract

The invention relates to the technical field of medical detection, in particular to a method for detecting cardiovascular and cerebrovascular diseases based on blood pressure factor combination and a device thereof. The method comprises the following steps: reading in the 24-hour systolic blood pressure (SBP), the diastolic blood pressure (DBP) and the heart rate (HR) obtained by a blood pressure detecting instrument; computing the averages of the SBP, the DBP and HR; computing the non-invasive blood pressure (NBP) value according to the formula by using the averages of the SBP, the DBP and HR; obtaining the morbidity of the cardiovascular and cerebrovascular diseases according to the reference database corresponding to the NBP value; and outputting the morbidity of the cardiovascular and cerebrovascular diseases. The method and the device can pertinently provide reasonable and proper prevention suggestions and have practical value for the patients and the professional doctors.

Description

Detect the device of cardiovascular and cerebrovascular disease based on the blood pressure factor combination

Technical field

The present invention relates to technical field of medical detection, be specifically related to a kind of method and device thereof that detects cardiovascular and cerebrovascular disease based on the blood pressure factor combination.

Background technology

Cardiovascular disease is dead and disabled first cause.For avoiding heart disease to cause death, serious disease and deformity, the situation of guarder's cardiovascular system is very important, analyze and monitor the data that get, to determine in people's cardiovascular system, whether existing any condition of illness that should treat, further degenerate with the cardiovascular system that prevents the patient.

Cardiovascular system of human body is the nonlinear system of a complexity, many signals wherein such as electrocardiosignal, cardiechema signals, pulse signal are containing abundant nonlinear kinetics information, people have attempted the aid decision that adopts these information to carry out cardiovascular disease diagnosis and treatment, as:

Chinese patent application 200410025233.3 discloses a kind of noinvasive triage survey method of cardiovascular dynamics parameter.Its step is, the pulse that gathers first the area on the wrist over the radial artery where the pulse is felt for diagnosis GUAN spot involves blood pressure information, the nominal pressure pulse wave, determine 10 characteristic points wherein, extract 14 characteristic quantities, calculate to obtain thus the cardiovascular dynamics parameter, comprising: pulse frequency, left ventricular ejection time, Ve pressures, intra-arterial jet pressure, average pulse pressure, mean arterial pressure, the easypro last capacity of the heart, ejection fraction, whenever fight blood volume, cardiac output, peripheral vascular resistance, arterial compliance etc.These parameters can be described blood pressure physiological change rule, and judge the personalized classification of blood pressure, are the important objective basis of the aid decision of the personalized diagnosis of disease such as hypertension and treatment.

Chinese patent application 200510061152.3 discloses the hyperpietic's cardiovascular risk grading appraisal procedure based on artificial neural network, by input measured's systolic pressure, diastolic pressure, Body Mass Index, ejection time, stroke volume, cardiac output, arterial stiffness index, pulse wave conduction speed, system's vascular resistance index, ten parameters of left heart performance index, (W2f1 (W1X+B1)+B2) calculates the cardiovascular risk grading that obtains the measured to utilize neutral net equation Y=f2.

Chinese patent application 200680041519.8 discloses a kind of for management or control cardiovascular related diseases especially hypertensive system and method, mainly comprises blood pressure measurement device and is used for determining the device of Autonomic nervous system activity state.Especially, this state determine be based on changes in heart rate or based on the granulocyte in the described individual leukocyte and lymphocytic proportion of composing.

Chinese patent application 200710115140.3 discloses a kind of method and apparatus of human body systema cariovasculare functional state, can harmless synchronous detecting cardiac function, arteriosclerosis degree, the blood viscosity level of noinvasive.

Clinically, the height of control blood pressure level is the important protective measure of cardiovascular and cerebrovascular vessel, studies show that in recent years, and fluctuation of blood pressure amplitude (BPV) increases with cardiovascular and cerebrovascular disease also close relationship.Large quantity research confirms: systolic pressure (SBP), diastolic pressure (DBP) and BPV are the independent hazard factors that causes target organ damage.Yet the relatedness of these blood pressure principal elements of SBP, DBP and BPV and target organ damage also rests on a qualitatively level.Up to the present, SBP, DBP and BPV are still unclear to the shared proportion of target organ damage, and the key element of each blood pressure yet is not very strong on statistical significance with the target organ damage relatedness independently, and namely the p value is not also less than 0.001.

Summary of the invention

Technical problem to be solved by this invention provides a kind of method and device thereof that detects cardiovascular and cerebrovascular disease based on the blood pressure factor combination.

A kind of method based on blood pressure factor combination detection cardiovascular and cerebrovascular disease comprises the following steps:

A) read in the instrument for measuring blood pressure device and obtain 24 hours systolic pressure SBP, diastolic pressure DBP and heart rate HR;

B) calculate systolic pressure meansigma methods SBP, diastolic pressure meansigma methods DBP and heart rate meansigma methods HR;

C) systolic pressure meansigma methods SBP, diastolic pressure meansigma methods DBP and heart rate meansigma methods HR are by formula

$\mathrm{NBP}=\frac{\mathrm{SBP}\×{\mathrm{HR}}^{0.2}}{{\mathrm{DBP}}^{0.8}}$

Calculate the NBP value;

D) according to the corresponding reference database of NBP value, obtain the sickness rate of cardiovascular and cerebrovascular disease;

E) sickness rate of output cardiovascular and cerebrovascular disease.

The diseases such as described cardiovascular and cerebrovascular disease such as myocardium infarction, congestive heart failure, cerebral infarction, coronary heart disease, recessive myocardial ischemia, diabetes, hypertension wherein are preferably cerebral infarction.

The device of realizing the inventive method has a data processor (especially microprocessor) at least, at least one memory element and at least one gauge (especially blood pressure measuring instrument) so that from the tremulous pulse of the blood that flowing detectable signal.A kind of like this equipment has the inventive method of realization needed all essential instrument and instruments.

In order to carry out simply at least one blood pressure parameter, fast and effectively to determine, make a kind of instrument of measuring at upper arm, wrist or finger.Other surface measurement also is fine, and these surface measurements are noninvasive.

For the healthcare givers who conveniently goes out also can accurately carry out the definite of cardio-vascular parameters, equipment can be simplified, and data processor, memory element and measurement device are set to one and are proved to be favourable.The result who does like this is to make as a whole described equipment and have very compact structure, space that only need to be very little.Make in this way, the definite of the cardio-vascular parameters that carries out within the long time period just can be simplified, this is that so user even also can carry in travelling, and measurement data can be stored in the memory element because described equipment is because its compact conformation transports easily.

According to another concept of the present invention, described memory element is used for storing several reference databases.Different reference databases can be for different personnel's parameter, so that described equipment also can be used for different personnel or be applicable to its relatives.

According to another concept of the present invention, described device has the interface of swap data.Make in this way, measured parameter can be stored within the longer time in another larger memorizer, so that can collect correction data within the longer time.

The analysis that the method for the invention is set up, computation model science are by force, high with zoopery and human trial matching degree, the Pathophysiology mathematic(al) parameter that obtains can demonstrate the pathophysiology characteristic of cardiovascular disease preferably, sensitiveness of parameters is strong, significance is good, reasonable and appropriate control suggestion can be provided targetedly, all with practical value to patient and medical practitioner.The apparatus structure that provides according to the inventive method is simple, and is easy to use, can realize that not damaged detects, and acquired results is reliable.

Figure of description

Fig. 1 is the flow chart of the method for the invention.

The specific embodiment

Below in conjunction with specific embodiment, further illustrate the present invention.Should be understood that these embodiment only to be used for explanation the present invention and be not used in and limit the scope of the invention.The experimental technique of unreceipted actual conditions in the following example, usually according to normal condition, or the condition of advising according to manufacturer.Ratio and percentage ratio are based on weight, unless stated otherwise.

Adopt retrospective study, 1526 routine patients be object of study, and those selected be the male greater than 60 years old, carry out the detection of 24 hr Ambulatory EKG Monitoring after being admitted to hospital, and get rid of that various acute diseases are shown effect, the patient of malignant tumor late period, valvular heart disease.24 hours Hotler with 30 minutes daytimes, night with systolic pressure SBP of 60 minutes records, diastolic pressure DBP and heart rate HR; Calculate systolic pressure meansigma methods SBP, diastolic pressure meansigma methods DBP and heart rate meansigma methods HR; Systolic pressure meansigma methods SBP, diastolic pressure meansigma methods DBP and heart rate meansigma methods HR are by formula

$\mathrm{NBP}=\frac{\mathrm{SBP}\×{\mathrm{HR}}^{0.2}}{{\mathrm{DBP}}^{0.8}}$

Calculate the NBP value; The probability of judging this patient's Cerebral Infarction according to the NBP value is big or small, i.e. the Cerebral Infarction rate.The NBP value is less, and to deliver probability larger.For more than 1000 patients' statistical result, can obtain following tables of data:

NBP	The Cerebral Infarction rate
		1.0	0.92
1.3	0.90
		1.4	0.88
1.6	0.86
		1.7	0.84
1.9	0.82
		2.0	0.80

[0031]

2.1	0.77
		2.2	0.74
2.4	0.70
		2.5	0.66
2.7	0.63
		2.8	0.60
3.1	0.55
		3.3	0.51
3.5	0.47
		4.0	0.43
4.5	0.39
		5.7	0.35

Because contain the interference of a large amount of other factors among the result of actual clinical statistics, data for any clinical data statistics all disperse, so sickness rate (such as cerebral infarction) can not be a kind of desirable smooth change with the variation that affects a certain factor of disease (such as a certain index of blood pressure), always can make up and down randomized jitter round the trend curve of that desirable smooth change, but these discrete data can show a kind of basic trend, and this basic trend tends to present dull rising or downward trend.In order to allow such judgement have more quantitative characteristics.The present invention adopts " smoothed curve " method commonly used on the mathematics, can be from discrete data acquisition basic trend curve.

As the judgement of a kind of such trend curve for clinical value size, people judge based on smoothed curve and the discrete data point difference size of expressing variation tendency that often the less clinical value of difference is just larger.Expressing such difference size from mathematical expression is exactly to utilize the standard deviation of i value Fi of Cerebral Haemorrhage Invasion Rate practical measurement i the value fi corresponding with its tendency change curve, embodies as follows:

$\mathrm{\σ}=\sqrt{\frac{\underset{i=1}{\overset{n}{\mathrm{\Σ}}}{(F_i-f_i)}^2}{n}}$

Actual sickness rate data differ less with expressing this sickness rate with the trend curve that certain blood pressure index changes, and represent that then both relatednesss are better.The less expression dispersion of σ is less, and relatedness is better, and clinical meaning is larger.

Applied Computer Techniques shows between NBP and cerebral infarction tendency change curve that σ is minimum, with the degree of association of cerebral infarction the most closely (p＜0.001).

Scope of the present invention is not subjected to the restriction of described specific embodiments, and described embodiment also comprises method and the component of functional equivalent only as the single example of illustrating various aspects of the present invention in the scope of the invention.In fact, except content as herein described, those skilled in the art can easily grasp multiple improvement of the present invention with reference to above description and accompanying drawing.Described improvement also falls within the scope of appended claims.Every piece of list of references mentioned above is listed this paper in as a reference all in full.

Claims (4)

1. device that detects cardiovascular and cerebrovascular disease based on the blood pressure factor combination, it is characterized in that this device has a data blood processor at least, at least one memory element and at least one blood pressure measuring instrument, wherein said data processing equipment reads in blood pressure measuring instrument and obtains 24 hours systolic pressures, diastolic pressure and heart rate calculate systolic pressure meansigma methods SBP, diastolic pressure meansigma methods DBP and heart rate meansigma methods HR, systolic pressure meansigma methods SBP, diastolic pressure meansigma methods DBP and heart rate meansigma methods HR are by formula

$\mathrm{NBP}=\frac{\mathrm{SBP}\×{\mathrm{HR}}^{0.2}}{\mathrm{DB}{P}^{0.8}}$

Calculate the NBP value,

According to the NBP-Cerebral Infarction rate reference database of the corresponding described cell stores of NBP value, obtain the sickness rate of cerebral infarction; The sickness rate of output cerebral infarction.

2. device as claimed in claim 1 is characterized in that described blood pressure measuring instrument is 24 hr Ambulatory EKG Monitoring detecting instruments.

3. device as claimed in claim 1 is characterized in that described data processing equipment, memory element and blood pressure measuring instrument are set to one.

4. device as claimed in claim 1 is characterized in that described device has the interface of swap data.

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