CN101845070B - 抗肿瘤药物卡培他滨的合成方法 - Google Patents
抗肿瘤药物卡培他滨的合成方法 Download PDFInfo
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- CN101845070B CN101845070B CN2010102002554A CN201010200255A CN101845070B CN 101845070 B CN101845070 B CN 101845070B CN 2010102002554 A CN2010102002554 A CN 2010102002554A CN 201010200255 A CN201010200255 A CN 201010200255A CN 101845070 B CN101845070 B CN 101845070B
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- capecitabine
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- JAUQZVBVVJJRKM-WMXYBCMPSA-N CC(C)(OC12)O[C@H]1O[C@H](CO)C2O Chemical compound CC(C)(OC12)O[C@H]1O[C@H](CO)C2O JAUQZVBVVJJRKM-WMXYBCMPSA-N 0.000 description 1
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- HGMROTSBOIGODR-LCIXKPCESA-N CCCCCCOC(NC(/C(/F)=C\N[C@@H](C1O)O[C@H](C)C1O)=N)=O Chemical compound CCCCCCOC(NC(/C(/F)=C\N[C@@H](C1O)O[C@H](C)C1O)=N)=O HGMROTSBOIGODR-LCIXKPCESA-N 0.000 description 1
- LSEJZXSEEBBEPK-WUCSKNBXSA-N CCCCCCOCNC(/C(/F)=C\N[C@@H]1O[C@H](C)C2OC(N)OC12)=N Chemical compound CCCCCCOCNC(/C(/F)=C\N[C@@H]1O[C@H](C)C2OC(N)OC12)=N LSEJZXSEEBBEPK-WUCSKNBXSA-N 0.000 description 1
- RUGIXSSILYANBI-ITUFNEAUSA-N CCCCCCO[F]/C(/C(N)=N)=C/N[C@@H](C1OC(C)=O)O[C@H](C)C1OC(C)=O Chemical compound CCCCCCO[F]/C(/C(N)=N)=C/N[C@@H](C1OC(C)=O)O[C@H](C)C1OC(C)=O RUGIXSSILYANBI-ITUFNEAUSA-N 0.000 description 1
- NWJBWNIUGNXJGO-UTZHYKEESA-N C[C@H](C(C1OC(C)=O)OC(C)=O)O[C@H]1N(C=C(C(N)=N1)F)C1=O Chemical compound C[C@H](C(C1OC(C)=O)OC(C)=O)O[C@H]1N(C=C(C(N)=N1)F)C1=O NWJBWNIUGNXJGO-UTZHYKEESA-N 0.000 description 1
- KXVKSUBVNIDIHE-XYMCDPRQSA-N C[C@H](C1O)OC(N/C=C(\C(N)=N)/F)=C1O Chemical compound C[C@H](C1O)OC(N/C=C(\C(N)=N)/F)=C1O KXVKSUBVNIDIHE-XYMCDPRQSA-N 0.000 description 1
- FMDFMIMQUYUJBM-RORPDPNFSA-N C[C@H](C1OC(C)=O)OCC1OC(C)=O Chemical compound C[C@H](C1OC(C)=O)OCC1OC(C)=O FMDFMIMQUYUJBM-RORPDPNFSA-N 0.000 description 1
- NPAFZOPVUMUVRF-KNILDQKGSA-N C[C@H](C1OC(O)OC11)O[C@H]1N/C=C(\C(C)=N)/F Chemical compound C[C@H](C1OC(O)OC11)O[C@H]1N/C=C(\C(C)=N)/F NPAFZOPVUMUVRF-KNILDQKGSA-N 0.000 description 1
- HYOYQXZPKDHEAF-WMXYBCMPSA-N C[C@H]1O[C@@H]2OC(C)(C)OC2C1O Chemical compound C[C@H]1O[C@@H]2OC(C)(C)OC2C1O HYOYQXZPKDHEAF-WMXYBCMPSA-N 0.000 description 1
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Abstract
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Claims (8)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN2010102002554A CN101845070B (zh) | 2010-05-25 | 2010-06-04 | 抗肿瘤药物卡培他滨的合成方法 |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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CN201010181792.9 | 2010-05-25 | ||
CN201010181792 | 2010-05-25 | ||
CN2010102002554A CN101845070B (zh) | 2010-05-25 | 2010-06-04 | 抗肿瘤药物卡培他滨的合成方法 |
Publications (2)
Publication Number | Publication Date |
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CN101845070A CN101845070A (zh) | 2010-09-29 |
CN101845070B true CN101845070B (zh) | 2012-05-16 |
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CN2010102002554A Expired - Fee Related CN101845070B (zh) | 2010-05-25 | 2010-06-04 | 抗肿瘤药物卡培他滨的合成方法 |
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CN (1) | CN101845070B (zh) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102424697B (zh) * | 2011-10-27 | 2014-02-12 | 齐鲁天和惠世制药有限公司 | 2′,3′-二-o-乙酰基-5′-脱氧-5-氟胞苷鎓盐类化合物及其制备方法 |
CN103193842A (zh) * | 2013-04-23 | 2013-07-10 | 济宁高新技术开发区永丰化工厂 | 卡培他滨的合成方法 |
CN103897006A (zh) * | 2013-12-18 | 2014-07-02 | 吉林修正药业新药开发有限公司 | 一种卡培他滨异构体的制备方法 |
CN106478751B (zh) * | 2015-09-02 | 2020-06-26 | 正大天晴药业集团股份有限公司 | 2′,3′-二-o-乙酰-5′-脱氧-5-氟-n4-[(戊氧基)羰基]胞嘧啶核苷的制备方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008144980A1 (fr) * | 2007-05-25 | 2008-12-04 | Topharman Shanghai Co., Ltd. | Procédé de préparation et intermédiaires de la capécitabine |
WO2009071726A1 (es) * | 2007-12-06 | 2009-06-11 | Coll Farma S.L. | Un procedimiento para la preparación de capecitabina e intermediarios utilizables en dicho procedimiento |
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2010
- 2010-06-04 CN CN2010102002554A patent/CN101845070B/zh not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008144980A1 (fr) * | 2007-05-25 | 2008-12-04 | Topharman Shanghai Co., Ltd. | Procédé de préparation et intermédiaires de la capécitabine |
WO2009071726A1 (es) * | 2007-12-06 | 2009-06-11 | Coll Farma S.L. | Un procedimiento para la preparación de capecitabina e intermediarios utilizables en dicho procedimiento |
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CN101845070A (zh) | 2010-09-29 |
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Application publication date: 20100929 Assignee: HENAN PURUI PHARMACEUTICAL CO., LTD. Assignor: Zhengzhou University Contract record no.: 2012410000082 Denomination of invention: Synthesis method of antineoplastic medicine capecitabine Granted publication date: 20120516 License type: Exclusive License Record date: 20121101 |
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