CN101810892B - Method for filtering liquid medicine and application of composite membrane in filtering liquid medicine - Google Patents
Method for filtering liquid medicine and application of composite membrane in filtering liquid medicine Download PDFInfo
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Abstract
The invention provides a method for filtering a liquid medicine. In the method, a composite membrane is used as a filter membrane, and the composite membrane comprises a polyether sulfone membrane and a primary filter layer, wherein the average pore diameter of the polyether sulfone membrane is smaller than that of the primary filter layer, and the primary filter layer is made of polypropylene non-woven fabric, polyester non-woven fabric, nylon membrane or glass woven fabric; and the liquid medicine flows in from one side of the primary filter layer and flows out from one side of the polyether sulfone membrane. After the liquid medicine flows through the primary filter layer to be primarily filtered, most of the greater insoluble particles are trapped on the primary filter layer without blocking the polyether sulfone membrane, thereby the filtering velocity can not be influenced and reduction in flow can not take place; synchronously, after the fibers of the primary filter layer fall into the liquid medicine, the falling fibers are trapped while the liquid medicine flows through the polyether sulfone membrane without entering human body, thereby the liquid medicine can not be polluted, and the human body can not be injured.
Description
Technical field
The present invention relates to the biological medical polymer material technical field, relate in particular to a kind of medicine filter method and the application of composite membrane in filtering liquid medicine.
Background technology
Fluid transport therapy can replenish nutrient substance, moisture, electrolyte of needed by human etc., has very important effect in clinical treatment.But general infusion set can only be with diameter in the medicinal liquid in the microgranule filtering more than 20 microns, is that 6 microns-10 microns microgranule does not have crown_interception to diameter.Particulate matter in the medicine has larger harm to human body, may cause the anaphylaxiss such as erythema, pruritus, swelling, even formation phlebothrombosis obstruction microcirculation causes the downright bad or damage in various degree of tissue or organ.Therefore, the research of filter membrane becomes one of focus in liquid medicine filter, the especially medicine filter.
Prior art discloses multiple-medicinal-liquid filter filter membrane, clinically uses more filter membrane to be fiber-like filter membrane or the Flat Membrane such as polyester core pore membrane, poly (ether sulfone) film such as polypropylene non-woven fabric film, cellulose mixture film, nylon membrane at present.But, the fiber-like filter membranes such as existing nylon membrane, fibrous membrane or polypropylene non-woven fabric film generally form by the stack that repeats of fiber, the fenestra out-of-shape of this type of membrane material, pore diameter distribution is inhomogeneous, thereby can't carry out targetedly filtering particulate matter of accurate classification, and, because fibre shedding in use occurs in fibrous membrane easily, the fiber that comes off can produce larger harm to human body along with medicinal liquid enters human body.And polyester core pore membrane, poly (ether sulfone) film etc. are generally Flat Membrane, although the film smooth surface, bore dia is even,, the fenestra of this type of film top layer filter material is open fenestra, porosity, along with the increase of infusion amount, microgranule increases in film surface accumulated amount, stop up fenestra, cause filtering velocity decline, flux depression, after the 500mL that especially infuses, the flux depression phenomenon is serious.
Summary of the invention
In view of this, technical problem to be solved by this invention is to provide a kind of medical filtration method and the application of composite membrane in medical filtration, by method provided by the invention fibre shedding occuring neither in the medical filtration process and pollute medicinal liquid, does not also produce the depleted filtering velocity that affects of flow.
The invention provides a kind of method of filtering liquid medicine, comprising:
Take composite membrane as filter membrane, described composite membrane comprises poly (ether sulfone) film and primary filter layer, described polyether sulfone
The average pore diameter of film is less than the average pore diameter of described primary filter layer, and described primary filter layer is polypropylene non-woven fabric, polyester non-woven fabric, nylon membrane or glass fabric;
Make medicinal liquid by described primary filter layer one side inflow, gone out by described poly (ether sulfone) film one effluent.
Preferably, described poly (ether sulfone) film is the poly (ether sulfone) film that contains hydrophilic group.
Preferably, described poly (ether sulfone) film is the phenolphthalein poly (ether sulfone) film that contains pendant tertiary amine group.
Preferably, the average pore diameter of described poly (ether sulfone) film is 2 μ m-15 μ m.
Preferably, the average pore diameter of described poly (ether sulfone) film is 2 μ m-10 μ m.
Preferably, the thickness of described poly (ether sulfone) film is 10 μ m-100 μ m.
Preferably, the thickness of described primary filter layer is 100 μ m-300 μ m.
The present invention also provides the application of a kind of composite membrane in filtering liquid medicine, described composite membrane comprises poly (ether sulfone) film and primary filter layer, the average pore diameter of described poly (ether sulfone) film is less than the average pore diameter of described primary filter layer, and described primary filter layer is polypropylene non-woven fabric, polyester non-woven fabric, nylon membrane or glass fibre.
Preferably, described poly (ether sulfone) film is the poly (ether sulfone) film that contains hydrophilic group.
Preferably, described poly (ether sulfone) film is the phenolphthalein poly (ether sulfone) film that contains pendant tertiary amine group.
Compared with prior art, the present invention is take the composite membrane that comprises poly (ether sulfone) film and primary filter layer as filter membrane, make medicinal liquid by larger primary filter layer one side inflow of average pore diameter, poly (ether sulfone) film one effluent less by average pore diameter goes out, thereby the particulate matter in the medicinal liquid is filtered.The primary filter layer is the fiber-like films such as polypropylene non-woven fabric, polyester non-woven fabric, nylon membrane or glass fabric, has the larger hole that the fiber stack forms, when medicinal liquid is flowed through the primary filter layer, insoluble granule larger in the medicinal liquid is trapped, when medicinal liquid is flowed through the less poly (ether sulfone) film of bore dia, insoluble granule less in the medicinal liquid is trapped, and reaches preferably filter effect.Medicinal liquid is flowed through behind the primary filter layer primary filter, and the insoluble granule that major part is larger is trapped within the primary filter layer, can not stop up poly (ether sulfone) film, thereby can not affect filtering velocity, can not produce flow depletion.Simultaneously, after the fiber of primary filter layer came off and enters medicinal liquid, the fiber that comes off when flowing through poly (ether sulfone) film with medicinal liquid was trapped, and can not enter human body, thereby can not pollute medicinal liquid, can not damage human body.Further, the present invention preferably uses the poly (ether sulfone) film with hydrophilic group, has reduced the Organic substances such as protein and has assembled the probability of blocking fenestra at poly (ether sulfone) film, is conducive to flux and keeps.
Description of drawings
The structural representation of the composite membrane that Fig. 1 provides for the embodiment of the invention;
Medicinal liquid flows to sketch map during use composite membrane filtering liquid medicine that Fig. 2 provides for the embodiment of the invention.
The specific embodiment
The invention provides a kind of method of filtering liquid medicine, comprising:
Take composite membrane as filter membrane, described composite membrane comprises poly (ether sulfone) film and primary filter layer, the average pore diameter of described poly (ether sulfone) film is less than the average pore diameter of described primary filter layer, and described primary filter layer is polypropylene non-woven fabric, polyester non-woven fabric, nylon membrane or glass fabric;
Make medicinal liquid by described primary filter layer one side inflow, gone out by described poly (ether sulfone) film one effluent.
Contain particulate matter in the medicinal liquid, these particulate matters enter blood of human body and can work the mischief to human body, therefore, need to filter medicinal liquid, and particulate matter is removed.The present invention is to have double-deck composite membrane as the membrane filtration medicinal liquid.According to the present invention, described composite membrane comprises poly (ether sulfone) film and primary filter layer double-layer structure, and referring to Fig. 1, Fig. 1 is the structural representation of composite membrane provided by the invention, and wherein, 1 is the primary filter layer, and 2 is the polyether sulfone layer.During filtering liquid medicine, medicinal liquid is by larger primary filter layer 1 one side inflow of average pore diameter, and poly (ether sulfone) film 2 one effluents less by average pore diameter go out, and referring to Fig. 2, medicinal liquid flows to sketch map during use composite membrane filtering liquid medicine that Fig. 2 provides for the embodiment of the invention.The medicinal liquid primary filter layer 1 of at first flowing through, larger particulate matter 3 is trapped, the medicinal liquid poly (ether sulfone) film 2 that continues to flow through, less particulate matter 4 is trapped, thereby obtains the lower medicinal liquid of particulate matter content.
The present invention does not have particular restriction to described primary filter layer, and the average pore diameter of described primary filter layer is preferably 10 μ m-50 μ m, more preferably 10 μ m-30 μ m; The thickness of described primary filter layer is preferably 100 μ m-300 μ m, more preferably 100 μ m-200 μ m.
The present invention does not have particular restriction to described poly (ether sulfone) film, and the average pore diameter of described poly (ether sulfone) film is preferably 2 μ m-15 μ m, more preferably 2 μ m-10 μ m; The thickness of described poly (ether sulfone) film is preferably 10 μ m-100 μ m, more preferably 10 μ m-80 μ m.
The present invention does not have particular restriction to the source of described composite membrane, preferably in accordance with the following methods preparation:
Polyether sulfone is dissolved in the solvent, adds additive, fully stir, obtain casting solution;
With described casting solution curtain coating to pre-prepd primary filter layer, then will soak the primary filter layer scraper knifing of casting solution, primary filter layer behind the knifing is left standstill behind the 20s-200s immersion precipitation in air bathe, behind the 1min-5min primary filter layer is taken out, obtain composite membrane after cleaning, the drying; Described primary filter layer is polypropylene non-woven fabric, polyester non-woven fabric, nylon membrane or glass fabric.
Wherein, described solvent is preferably one or more in dimethyl formamide, dimethyl acetylamide, N-Methyl pyrrolidone, dimethyl sulfoxide or the oxolane; Described additive is preferably one or more in polyvinylpyrrolidone, Polyethylene Glycol, ethylene glycol monomethyl ether or the glycerol; Described coagulation bath is preferably one or more organic aqueous solutions that contain in dimethyl formamide, dimethyl acetylamide, N-Methyl pyrrolidone, dimethyl sulfoxide, polyvinylpyrrolidone, Polyethylene Glycol, ethylene glycol monomethyl ether or the oxolane, and the content of described organic matter is preferably 20wt%-80wt%.
Because polyether sulfone hydrophilic is relatively poor, stop up fenestra on the poly (ether sulfone) film in order to prevent that organic molecules such as protein in the medicinal liquid are adsorbed on, described poly (ether sulfone) film is preferably the poly (ether sulfone) film that contains hydrophilic group, more preferably contains the phenolphthalein poly (ether sulfone) film of pendant tertiary amine group.The present invention does not have particular restriction to the described preparation method that contains the poly (ether sulfone) film of hydrophilic group, is preferably the disclosed method preparation according to Chinese patent literature CN101219350A.
According to the present invention, the described phenolphthalein polyether sulfone that contains pendant tertiary amine group preferably has formula (I) structure:
Wherein, m represents-CH
2The number of-group, m is 0 or positive integer;
N represents the degree of polymerization, and n is positive integer.
The present invention does not have particular restriction to the described preparation method that contains the phenolphthalein polyether sulfone of pendant tertiary amine group, preferably in accordance with the following methods preparation:
In phenolphthalein, add asymmetric amine, under 20 ℃-200 ℃ condition, react, obtain containing the phenolphthalein biphenol monomer of pendant tertiary amine group;
Add halogenated organic monomer or nitrated Organic substance monomer, catalysts and solvents in the described phenolphthalein biphenol monomer that contains pendant tertiary amine group, under 80 ℃-220 ℃ condition, react, obtain containing the phenolphthalein polyether sulfone of pendant tertiary amine group.
Wherein, described asymmetric amine one end contains amino, and an end contains tertiary amine, and general structure is suc as formula (II):
Wherein, m represents-CH
2The number of-group, m is 0 or positive integer.
Described halogenated organic monomer is preferably 4,4 '-difluorodiphenyl sulfone, 4,4 '-dichloro diphenyl sulfone, 4,4 '-difluoro benzophenone, 4,4 '-two chloro benzophenones or perfluorinated biphenyl; Described catalyst is preferably sodium carbonate, potassium carbonate or cesium carbonate; Described solvent is preferably DMF, N,N-dimethylacetamide, dimethyl sulfoxine, N-Methyl pyrrolidone, sulfolane or diphenyl sulphone (DPS).
The present invention also provides the application of a kind of composite membrane in filtering liquid medicine, described composite membrane comprises poly (ether sulfone) film and primary filter layer, the average pore diameter of described poly (ether sulfone) film is less than the average pore diameter of described primary filter layer, and described primary filter layer is polypropylene non-woven fabric, polyester non-woven fabric, nylon membrane or glass fabric.
According to the present invention, described poly (ether sulfone) film is preferably the poly (ether sulfone) film that contains hydrophilic group, more preferably contains the phenolphthalein poly (ether sulfone) film of pendant tertiary amine group.
Compared with prior art, the present invention is take the composite membrane that comprises poly (ether sulfone) film and primary filter layer as filter membrane, make medicinal liquid by larger primary filter layer one side inflow of average pore diameter, poly (ether sulfone) film one effluent less by average pore diameter goes out, thereby the particulate matter in the medicinal liquid is filtered.The primary filter layer is the fiber-like films such as polypropylene non-woven fabric, polyester non-woven fabric, nylon membrane or glass fabric, has the larger hole that the fiber stack forms, when medicinal liquid is flowed through the primary filter layer, insoluble granule larger in the medicinal liquid is trapped, when medicinal liquid is flowed through the less poly (ether sulfone) film of bore dia, insoluble granule less in the medicinal liquid is trapped, and reaches preferably filter effect.Medicinal liquid is flowed through behind the primary filter layer primary filter, and the insoluble granule that major part is larger is trapped within on the primary filter layer, can not stop up poly (ether sulfone) film, thereby can not affect filtering velocity, can not produce flow depletion.Simultaneously, after the fiber of primary filter layer came off and enters medicinal liquid, the fiber that comes off when flowing through poly (ether sulfone) film with medicinal liquid was trapped, and can not enter human body, thereby can not pollute medicinal liquid, can not damage human body.Further, the present invention preferably uses the poly (ether sulfone) film with hydrophilic group, has reduced the Organic substances such as protein and has assembled the probability of blocking fenestra at poly (ether sulfone) film, is conducive to flux and keeps.
In order further to understand the present invention, below in conjunction with embodiment method and the application of composite membrane in filtering liquid medicine of filtering liquid medicine provided by the invention are described in detail.
20g polyether sulfone and 10g polyvinylpyrrolidone are dissolved in the 70g dimethyl acetylamide, be made into casting solution, behind casting solution standing and defoaming 24h, take average pore diameter as 25 μ m, thickness is that the polypropylene non-woven fabric of 120 μ m is as the primary filter layer, polypropylene non-woven fabric is immersed in the casting solution, then will soak the primary filter layer of casting solution pulls out, use the scraper knifing, gap between scraper is 200 μ m, the primary filter layer that to scrape casting solution leave standstill 120s in relative humidity is 40% air after immediately immersion precipitation separates out polyether sulfone in bathing, described coagulation bath is the solution that the water of the dimethyl acetylamide of 70wt% and 30wt% forms, after 2 minutes, primary filter layer and thereon polyether sulfone of precipitation are put into 70 ℃ water 4 minutes, obtain the polyether sulfone microporous compound film after taking out drying.
Use Electronic Speculum to measure the bore dia of poly (ether sulfone) film one side in the polyether sulfone microporous compound film, its average pore diameter is 2.15 μ m; Its thickness is the thickness=200 μ m-120 μ m=80 μ m of scraper gap-primary filter layer;
Test under 1m water column static pressure, the water flux of polyether sulfone microporous compound film is 10500L/m
2* h.
The polyether sulfone microporous compound film of embodiment 1 preparation is prepared into liquid medicine filter, under the 1m static pressure, normal saline is advanced from the polypropylene non-woven fabric primary filter laminar flow of polyether sulfone microporous compound film, go out from the polyether sulfone laminar flow, the average discharge of the liquid that 5min flows out is 96mL/cm
2
After filtering the 5L normal saline, the flow of filter is obviously not depleted;
Analyze to normal saline and through the liquid after filtering with GWF06JA type particle analysis gauge, analysis result shows, liquid medicine filter in the normal saline 〉=rejection rate of the particulate matter of 5 μ m is 100%.
20g polyether sulfone and 10g polyvinylpyrrolidone are dissolved in the 70g dimethyl acetylamide, be made into casting solution, behind casting solution standing and defoaming 24h, take average pore diameter as 25 μ m, thickness is that the polypropylene non-woven fabric of 120 μ m is as the primary filter layer, polypropylene non-woven fabric is immersed in the casting solution, then will soak the primary filter layer of casting solution pulls out, use the scraper knifing, gap between scraper is 200 μ m, the primary filter layer that to scrape casting solution leave standstill 120s in relative humidity is 50% air after immediately immersion precipitation separates out polyether sulfone in bathing, described coagulation bath is the solution that the water of the dimethyl acetylamide of 80wt% and 20wt% forms, after 2 minutes, primary filter layer and thereon polyether sulfone of precipitation are put into 70 ℃ water 3 minutes, obtain the polyether sulfone microporous compound film after taking out drying.
Use Electronic Speculum to measure the bore dia of poly (ether sulfone) film one side in the polyether sulfone microporous compound film, its average pore diameter is 6.14 μ m; Its thickness is the thickness=200 μ m-120 μ m=80 μ m of scraper gap-primary filter layer;
Test under 1m water column static pressure, the water flux of polyether sulfone microporous compound film is 12500L/m
2* h.
The polyether sulfone microporous compound film of embodiment 3 preparations is prepared into liquid medicine filter, under the 1m static pressure, normal saline is advanced from the polypropylene non-woven fabric primary filter laminar flow of polyether sulfone microporous compound film, go out from the polyether sulfone laminar flow, the average discharge of the liquid that 5min flows out is 125mL/cm
2
After filtering the 5L normal saline, the flow of filter is obviously not depleted;
Analyze to normal saline and through the liquid after filtering with GWF06JA type particle analysis gauge, analysis result shows, liquid medicine filter in the normal saline 〉=rejection rate of the particulate matter of 5 μ m is 97%.
Embodiment 5
15g polyether sulfone and 5g Polyethylene Glycol and 10g polyvinylpyrrolidone are dissolved in the 70g dimethyl formamide, be made into casting solution, behind casting solution standing and defoaming 24h, be 25 μ m with average pore diameter, thickness is that the polyester non-woven fabric primary filter layer of 150 μ m immerses in the casting solution, then will soak the primary filter layer of casting solution pulls out, use the scraper knifing, gap between scraper is 200 μ m, the primary filter layer that to scrape casting solution leave standstill 200s in relative humidity is 60% air after immediately immersion precipitation separates out polyether sulfone in bathing, described coagulation bath is the solution that the water of the dimethyl acetylamide of 80wt% and 20wt% forms, after 2 minutes, primary filter layer and thereon polyether sulfone of precipitation are put into 60 ℃ water 3 minutes, obtain the polyether sulfone microporous compound film after taking out drying.
Use Electronic Speculum to measure the bore dia of poly (ether sulfone) film one side in the polyether sulfone microporous compound film, its average pore diameter is 5.02 μ m; Its thickness is the thickness=200 μ m-150 μ m=50 μ m of scraper gap-primary filter layer;
Test under 1m water column static pressure, the water flux of polyether sulfone microporous compound film is 11800L/m
2* h.
Embodiment 6
The polyether sulfone microporous compound film of embodiment 5 preparations is prepared into liquid medicine filter, under the 1m static pressure, normal saline is advanced from the polyester non-woven fabric primary filter laminar flow of polyether sulfone microporous compound film, go out from the polyether sulfone laminar flow, the average discharge of the liquid that 5min flows out is 110mL/cm
2
After filtering the 5L normal saline, the flow of filter is obviously not depleted;
Analyze to normal saline and through the liquid after filtering with GWF06JA type particle analysis gauge, analysis result shows, liquid medicine filter in the normal saline 〉=rejection rate of the particulate matter of 5 μ m is 98%.
Embodiment 7
With the 15g polyether sulfone, 10g ethylene glycol monomethyl ether and 5g polyvinylpyrrolidone are dissolved in the 70g dimethyl acetylamide, be made into casting solution, behind casting solution standing and defoaming 24h, be 22 μ m with average pore diameter, thickness is that the nylon membrane primary filter layer of 100 μ m immerses in the casting solution, then will soak the primary filter layer of casting solution pulls out, use the scraper knifing, gap between scraper is 200 μ m, the primary filter layer that to scrape casting solution leave standstill 100s in relative humidity is 80% air after immediately immersion precipitation separates out polyether sulfone in bathing, described coagulation bath is the solution that the water of the dimethyl acetylamide of 80wt% and 20wt% forms, after 2 minutes, primary filter layer and thereon polyether sulfone of precipitation are put into 60 ℃ water 3 minutes, obtain the polyether sulfone microporous compound film after taking out drying.
Use Electronic Speculum to measure the bore dia of poly (ether sulfone) film one side in the polyether sulfone microporous compound film, its average pore diameter is 7.40 μ m; Its thickness is the thickness=200 μ m-100 μ m=100 μ m of scraper gap-primary filter layer;
Test under 1m water column static pressure, the water flux of polyether sulfone microporous compound film is 13600L/m
2* h.
Embodiment 8
The polyether sulfone microporous compound film of embodiment 7 preparations is prepared into liquid medicine filter, under the 1m static pressure, normal saline is advanced from the nylon membrane primary filter laminar flow of polyether sulfone microporous compound film, go out from the polyether sulfone laminar flow, the average discharge of the liquid that 5min flows out is 135mL/cm
2
After filtering the 5L normal saline, the flow of filter is obviously not depleted;
Analyze to normal saline and through the liquid after filtering with GWF06JA type particle analysis gauge, analysis result shows, liquid medicine filter in the normal saline 〉=rejection rate of the particulate matter of 5 μ m is 96%.
Embodiment 9
In the three-necked bottle that mechanical agitation, condenser and water knockout drum are housed, add 0.1mol phenolphthalein and 0.1molN, N-dimethylaminopropylamine; In three-necked bottle, pass into nitrogen, and it slowly is warming up to 120 ℃, make that material reacts in the three-necked bottle, generate the phenolphthalein monomer that contains pendant tertiary amine group;
In the three-necked bottle that mechanical agitation, condensing tube and water knockout drum are housed, add the phenolphthalein monomer that 0.1mol contains pendant tertiary amine group, 0.1mol4,4 '-dichloro diphenyl sulfone, 0.2mol Anhydrous potassium carbonate, 138mL dimethyl sulfoxine, 70mL toluene; In three-necked bottle, pass into nitrogen, and three-necked bottle is warming up to 150 ℃ gradually, make refluxing toluene, reflux after 4 hours, progressively toluene is steamed, slowly be warming up to 180 ℃, make that material carries out polyreaction in the three-necked bottle.
React after 10 hours, cooling makes the system cool to room temperature, adds DMF (DMF) dilution, removes by filter insoluble matter; Become the thread shape to pour into filtrate and separate out the white silk shaped polymer in the water of rapid stirring; Filter collected polymer, repeated multiple times washing, 120 ℃ of vacuum dryings 12 hours obtain containing the phenolphthalein polyether sulfone of pendant tertiary amine group.
The phenolphthalein polyether sulfone that 15g is contained pendant tertiary amine group, 10g ethylene glycol monomethyl ether and 5g polyvinylpyrrolidone are dissolved in the 70g dimethyl acetylamide, be made into casting solution, behind casting solution standing and defoaming 24h, be 12 μ m with average pore diameter, thickness is that the nylon membrane primary filter layer of 100 μ m immerses in the casting solution, then will soak the primary filter layer of casting solution pulls out, use the scraper knifing, gap between scraper is 200 μ m, the primary filter layer that to scrape casting solution leave standstill 100s in relative humidity is 80% air after immediately immersion precipitation separates out the phenolphthalein polyether sulfone that contains pendant tertiary amine group in bathing, described coagulation bath is the solution that the water of the dimethyl acetylamide of 80wt% and 20wt% forms, after 2 minutes, primary filter layer and thereon the phenolphthalein polyether sulfone that contains pendant tertiary amine group of precipitation are put into 60 ℃ water 3 minutes, obtain the polyether sulfone microporous compound film after taking out drying.
Use Electronic Speculum to measure the bore dia of polyether sulfone one side in the polyether sulfone microporous compound film, its average pore diameter is 8.45 μ m; Its thickness is the thickness=200 μ m-100 μ m=100 μ m of scraper gap-primary filter layer;
Test under 1m water column static pressure, the water flux of polyether sulfone microporous compound film is 14600L/m
2* h.
Embodiment 10
The polyether sulfone microporous compound film of embodiment 9 preparations is prepared into liquid medicine filter, under the 1m static pressure, normal saline is advanced from the nylon membrane primary filter laminar flow of polyether sulfone microporous compound film, go out from the phenolphthalein polyether sulfone laminar flow that contains pendant tertiary amine group, the average discharge of the liquid that 5min flows out is 140mL/cm
2
After filtering the 5L normal saline, the flow of filter is obviously not depleted;
Analyze to normal saline and through the liquid after filtering with GWF06JA type particle analysis gauge, analysis result shows, liquid medicine filter in the normal saline 〉=rejection rate of the particulate matter of 5 μ m is 92%.
The thickness of poly (ether sulfone) film described in the present specification refers to the thickness of the poly (ether sulfone) film beyond the primary filter layer, does not comprise the part of infiltration within the primary filter layer, and the thickness that scraper gap deducts the primary filter layer is the thickness of poly (ether sulfone) film.
The explanation of above embodiment just is used for helping to understand method of the present invention and core concept thereof.Should be pointed out that for those skilled in the art, under the prerequisite that does not break away from the principle of the invention, can also carry out some improvement and modification to the present invention, these improvement and modification also fall in the protection domain of claim of the present invention.
Claims (6)
1. the method for a filtering liquid medicine is characterized in that, comprising:
Take composite membrane as filter membrane, described composite membrane comprises poly (ether sulfone) film and primary filter layer, the average pore diameter of described poly (ether sulfone) film is less than the average pore diameter of described primary filter layer, and described primary filter layer is polypropylene non-woven fabric, polyester non-woven fabric, nylon membrane or glass fabric; Described poly (ether sulfone) film is the poly (ether sulfone) film that contains hydrophilic group, and the described poly (ether sulfone) film that contains hydrophilic group is the phenolphthalein poly (ether sulfone) film that contains pendant tertiary amine group;
The described phenolphthalein polyether sulfone that contains pendant tertiary amine group has following structure:
Wherein, m represents-CH
2The number of-group, m is 0 or positive integer;
N represents the degree of polymerization, and n is positive integer;
Make medicinal liquid by described primary filter layer one side inflow, gone out by described poly (ether sulfone) film one effluent.
2. method according to claim 1 is characterized in that, the average pore diameter of described poly (ether sulfone) film is 2 μ m-15 μ m.
3. method according to claim 1 and 2 is characterized in that, the average pore diameter of described poly (ether sulfone) film is 2 μ m-10 μ m.
4. method according to claim 1 is characterized in that, the thickness of described poly (ether sulfone) film is 10 μ m-100 μ m.
5. method according to claim 1 is characterized in that, the thickness of described primary filter layer is 100 μ m-300 μ m.
6. the application of composite membrane in filtering liquid medicine, described composite membrane comprises poly (ether sulfone) film and primary filter layer, the average pore diameter of described poly (ether sulfone) film is less than the average pore diameter of described primary filter layer, and described primary filter layer is polypropylene non-woven fabric, polyester non-woven fabric, nylon membrane or glass fabric; Described poly (ether sulfone) film is the poly (ether sulfone) film that contains hydrophilic group, and the described poly (ether sulfone) film that contains hydrophilic group is the phenolphthalein poly (ether sulfone) film that contains pendant tertiary amine group;
The described phenolphthalein polyether sulfone that contains pendant tertiary amine group has following structure:
Wherein, m represents-CH
2The number of-group, m is 0 or positive integer;
N represents the degree of polymerization, and n is positive integer.
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| DE102011114634A1 (en) * | 2011-10-04 | 2013-04-04 | Mn-Beteiligungs Gmbh | Abrasion resistant membrane and process for its preparation |
| CN104492286B (en) * | 2014-12-19 | 2016-10-05 | 天津工业大学 | The preparation of the absorption enhancement mode composite hyperfiltration membrane of a kind of supporting layer functionalization and application |
| CN106698766B (en) * | 2015-08-18 | 2019-08-06 | 上海康点实业有限公司 | Multistage treatment function kettle filter core |
| CN108325397B (en) * | 2018-02-06 | 2022-05-17 | 四会富仕电子科技股份有限公司 | Method for manufacturing inorganic microfiltration membrane |
| CN111603948B (en) * | 2020-05-21 | 2023-06-30 | 杭州科百特科技有限公司 | Nylon membrane and preparation method and application thereof |
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| CN1683059A (en) * | 2005-03-03 | 2005-10-19 | 上海一鸣过滤技术有限公司 | Reinforced hollow fiber super filter film and its preparing method |
| CN1730141A (en) * | 2005-08-04 | 2006-02-08 | 浙江大学 | Process for preparing co-mixed polyethersulfone platform complex film |
| CN101234306A (en) * | 2007-11-13 | 2008-08-06 | 清华大学 | Phthalazine poly(phthalaziane ether sulfone ketone) polymericcompound flat plate ultrafiltration membrane and preparation thereof |
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2010
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1683059A (en) * | 2005-03-03 | 2005-10-19 | 上海一鸣过滤技术有限公司 | Reinforced hollow fiber super filter film and its preparing method |
| CN1730141A (en) * | 2005-08-04 | 2006-02-08 | 浙江大学 | Process for preparing co-mixed polyethersulfone platform complex film |
| CN101234306A (en) * | 2007-11-13 | 2008-08-06 | 清华大学 | Phthalazine poly(phthalaziane ether sulfone ketone) polymericcompound flat plate ultrafiltration membrane and preparation thereof |
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