CN101804152A - Yixinshu tablet - Google Patents
Yixinshu tablet Download PDFInfo
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- CN101804152A CN101804152A CN 201010135024 CN201010135024A CN101804152A CN 101804152 A CN101804152 A CN 101804152A CN 201010135024 CN201010135024 CN 201010135024 CN 201010135024 A CN201010135024 A CN 201010135024A CN 101804152 A CN101804152 A CN 101804152A
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Abstract
The invention discloses a Yixinshu tablet which consists of the ingredients of 150-250g of ginseng, 150-250g of tuber of dwarf lilyturf, 95-150g of Chinese magnoliavine fruit, 150-250g of Astragalus membranaceus, 240-285g of radix salviae miltiorrhizae, 95-150g of Ligusticum wallichii, 150-250g of hawthorn, 20-60g of microcrystalline cellulose, 1-3g of magnesium stearate and proper amount of starch. Aiming at overcoming the disadvantages in the prior art, the invention provides the Yixinshu tablet which has better stability and is quick to disintegrate.
Description
Technical field
The present invention relates to a kind of Yixinshu tablet.
Background technology
The YIXINSHU Chinese medicine preparation has Yiqi and vein recovery, blood circulation promoting and blood stasis dispelling, the effect of YIN nourishing and the production of body fluid promoting, be used for deficiency of both QI and YIN, the cardiopalmus irregularly intermittent and regularly intermittent pulse, uncomfortable in chestly do not relax, chest pain and angina pectoris are seen the person that has the above-mentioned symptom, are widely used in treatment angina pectoris, myocardial ischemia, various arrhythmia, artrial premature beat, chest pain and angina pectoris trouble etc. at present clinically.But the easy moisture absorption of existing YIXINSHU Chinese medicinal capsule ubiquity content is softening, and caking goes mouldy, and disintegration time prolongs, and problems such as poor stability make troubles for packing, transportation and preservation etc.
Summary of the invention
The objective of the invention is provides a kind of good stability, the Yixinshu tablet that disintegration time is fast in order to overcome weak point of the prior art.
In order to achieve the above object, the present invention adopts following scheme:
A kind of Yixinshu tablet, composed of the following components:
Radix Ginseng 150～250g 150～250g Radix Ophiopogonis
Fructus Schisandrae Chinensis 95～150g Radix Astragali 150～250g
Radix Salviae Miltiorrhizae 240～285g Rhizoma Chuanxiong 95～150g
Fructus Crataegi 150～250g microcrystalline Cellulose 20～60g
Magnesium stearate 1～3g starch is an amount of.
Aforesaid Yixinshu tablet, composed of the following components:
Radix Ginseng 180～230g 180～230g Radix Ophiopogonis
Fructus Schisandrae Chinensis 100～140g Radix Astragali 170～220g
Radix Salviae Miltiorrhizae 250～275g Rhizoma Chuanxiong 100～140g
Fructus Crataegi 180～230g microcrystalline Cellulose 30～50g
Magnesium stearate 1.5～2.5g starch is an amount of.
Aforesaid Yixinshu tablet, composed of the following components:
Radix Ginseng 200g 200g Radix Ophiopogonis
Fructus Schisandrae Chinensis 133g Radix Astragali 200g
Radix Salviae Miltiorrhizae 267g Rhizoma Chuanxiong 133g
Fructus Crataegi 200g microcrystalline Cellulose 40g
Magnesium stearate 2g starch is an amount of.
Aforesaid Yixinshu tablet is characterized in that it is a tablet.
In sum, beneficial effect of the present invention:
Reasonable mixture ratio of components in the Yixinshu tablet of the present invention, and in prescription, added microcrystalline Cellulose, microcrystalline Cellulose has good compressibility, and has good bonding, fluidizer, disintegration concurrently, and the tablet that is pressed into has bigger hardness, and disintegration might as well; Also added an amount of magnesium stearate in the present invention's prescription, effectively reduced the frictional force between sticking and reduction granule and granule, tablet and the nib wall, made the tablet smooth and beautiful appearance, Yixinshu tablet good stability of the present invention.
The each dose of existing YIXINSHU JIAONANG is 4, and dose is bigger, and product YIXINSHU tablet of the present invention is because the effect that is squeezed, and respective volume reduces greatly than capsule, and tablet of the present invention can make to be taken quantity at every turn and be reduced to 3; Simultaneously tablet can film coating, and is attractive in appearance and effective ingredient protected, and reduces the influence of light, air, moisture etc.; And tablets and easy to carry, patient Geng Yi accepts.
The specific embodiment
Below in conjunction with the specific embodiment the present invention is described further:
Embodiment 1
Yixinshu tablet of the present invention, composed of the following components:
Radix Ginseng 150g 150g Radix Ophiopogonis
Fructus Schisandrae Chinensis 95g Radix Astragali 150g
Radix Salviae Miltiorrhizae 240g Rhizoma Chuanxiong 95g
Fructus Crataegi 150g microcrystalline Cellulose 20g
Magnesium stearate 1g starch is an amount of.
Get Radix Ginseng and pulverize, cross 100 mesh sieves, use pulsation vacuum sterilizer at 134 ℃, sterilization is standby after 1 hour down for 0.21Mpa; Get Fructus Schisandrae Chinensis, Radix Salviae Miltiorrhizae and add 5 times of amount 85% alcohol reflux 2 times, 3 hours for the first time, 1.5 hours for the second time, filter, merging filtrate is at 50 ℃, decompression recycling ethanol under the-0.08Mpa, and filtrate is concentrated into relative density 1.12～1.15 (20 ℃), pure extractum; Radix Ophiopogonis, the Radix Astragali, Rhizoma Chuanxiong, Fructus Crataegi are added 8 times of water gagings to be decocted 2 times, 2.5 hours for the first time, 1.5 hours for the second time, collecting decoction, filter, filtrate is concentrated into about 650ml, adds equivalent 85% ethanol, after fully stirring, standing over night, filter, filtrate is at 70 ℃, under-the 0.08Mpa decompression recycling ethanol and be concentrated into relative density 1.30～1.36 (80 ℃) the water extracted immersing paste; After above-mentioned two kinds of extractum merging, add above-mentioned Radix Ginseng fine powder, and add microcrystalline Cellulose, mix homogeneously is crossed 16 mesh sieve wet granulations with 80% ethanol, and 50 ℃ dry down, cross 20 mesh sieve granulate, dried granule adds magnesium stearate, and it is an amount of to add starch, regulates total amount to 380g, evenly mixed, be pressed into 1000, the bag film-coat promptly gets product Yixinshu tablet of the present invention.
Embodiment 2
Yixinshu tablet of the present invention, composed of the following components:
Radix Ginseng 250g 250g Radix Ophiopogonis
Fructus Schisandrae Chinensis 150g Radix Astragali 250g
Radix Salviae Miltiorrhizae 285g Rhizoma Chuanxiong 150g
Fructus Crataegi 250g microcrystalline Cellulose 60g
Magnesium stearate 3g starch is an amount of.
Get Radix Ginseng and pulverize, cross 100 mesh sieves, use pulsation vacuum sterilizer at 134 ℃, sterilization is standby after 1 hour down for 0.21Mpa; Get Fructus Schisandrae Chinensis, Radix Salviae Miltiorrhizae and add 5 times of amount 85% alcohol reflux 2 times, 3 hours for the first time, 1.5 hours for the second time, filter, merging filtrate is at 50 ℃, decompression recycling ethanol under the-0.08Mpa, and filtrate is concentrated into relative density 1.12～1.15 (20 ℃), pure extractum; Radix Ophiopogonis, the Radix Astragali, Rhizoma Chuanxiong, Fructus Crataegi are added 8 times of water gagings to be decocted 2 times, 2.5 hours for the first time, 1.5 hours for the second time, collecting decoction, filter, filtrate is concentrated into about 650ml, adds equivalent 85% ethanol, after fully stirring, standing over night, filter, filtrate is at 70 ℃, under-the 0.08Mpa decompression recycling ethanol and be concentrated into relative density 1.30～1.36 (80 ℃) the water extracted immersing paste; After above-mentioned two kinds of extractum merging, add above-mentioned Radix Ginseng fine powder, and add microcrystalline Cellulose, mix homogeneously is crossed 16 mesh sieve wet granulations with 80% ethanol, and 50 ℃ dry down, cross 20 mesh sieve granulate, dried granule adds magnesium stearate, and it is an amount of to add starch, regulates total amount to 380g, evenly mixed, be pressed into 1000, the bag film-coat promptly gets product Yixinshu tablet of the present invention.
Embodiment 3
Yixinshu tablet of the present invention, composed of the following components:
Radix Ginseng 180g 180g Radix Ophiopogonis
Fructus Schisandrae Chinensis 100g Radix Astragali 170g
Radix Salviae Miltiorrhizae 250g Rhizoma Chuanxiong 100g
Fructus Crataegi 180g microcrystalline Cellulose 30g
Magnesium stearate 1.5g starch is an amount of.
Get Radix Ginseng and pulverize, cross 100 mesh sieves, use pulsation vacuum sterilizer at 134 ℃, sterilization is standby after 1 hour down for 0.21Mpa; Get Fructus Schisandrae Chinensis, Radix Salviae Miltiorrhizae and add 5 times of amount 85% alcohol reflux 2 times, 3 hours for the first time, 1.5 hours for the second time, filter, merging filtrate is at 50 ℃, decompression recycling ethanol under the-0.08Mpa, and filtrate is concentrated into relative density 1.12～1.15 (20 ℃), pure extractum; Radix Ophiopogonis, the Radix Astragali, Rhizoma Chuanxiong, Fructus Crataegi are added 8 times of water gagings to be decocted 2 times, 2.5 hours for the first time, 1.5 hours for the second time, collecting decoction, filter, filtrate is concentrated into about 650ml, adds equivalent 85% ethanol, after fully stirring, standing over night, filter, filtrate is at 70 ℃, under-the 0.08Mpa decompression recycling ethanol and be concentrated into relative density 1.30～1.36 (80 ℃) the water extracted immersing paste; After above-mentioned two kinds of extractum merging, add above-mentioned Radix Ginseng fine powder, and add microcrystalline Cellulose, mix homogeneously is crossed 16 mesh sieve wet granulations with 80% ethanol, and 50 ℃ dry down, cross 20 mesh sieve granulate, dried granule adds magnesium stearate, and it is an amount of to add starch, regulates total amount to 380g, evenly mixed, be pressed into 1000, the bag film-coat promptly gets product Yixinshu tablet of the present invention.
Embodiment 4
Yixinshu tablet of the present invention, composed of the following components:
Radix Ginseng 230g 230g Radix Ophiopogonis
Fructus Schisandrae Chinensis 140g Radix Astragali 220g
Radix Salviae Miltiorrhizae 275g Rhizoma Chuanxiong 140g
Fructus Crataegi 230g microcrystalline Cellulose 50g
Magnesium stearate 2.5g starch is an amount of.
Get Radix Ginseng and pulverize, cross 100 mesh sieves, use pulsation vacuum sterilizer at 134 ℃, sterilization is standby after 1 hour down for 0.21Mpa; Get Fructus Schisandrae Chinensis, Radix Salviae Miltiorrhizae and add 5 times of amount 85% alcohol reflux 2 times, 3 hours for the first time, 1.5 hours for the second time, filter, merging filtrate is at 50 ℃, decompression recycling ethanol under the-0.08Mpa, and filtrate is concentrated into relative density 1.12～1.15 (20 ℃), pure extractum; Radix Ophiopogonis, the Radix Astragali, Rhizoma Chuanxiong, Fructus Crataegi are added 8 times of water gagings to be decocted 2 times, 2.5 hours for the first time, 1.5 hours for the second time, collecting decoction, filter, filtrate is concentrated into about 650ml, adds equivalent 85% ethanol, after fully stirring, standing over night, filter, filtrate is at 70 ℃, under-the 0.08Mpa decompression recycling ethanol and be concentrated into relative density 1.30～1.36 (80 ℃) the water extracted immersing paste; After above-mentioned two kinds of extractum merging, add above-mentioned Radix Ginseng fine powder, and add microcrystalline Cellulose, mix homogeneously is crossed 16 mesh sieve wet granulations with 80% ethanol, and 50 ℃ dry down, cross 20 mesh sieve granulate, dried granule adds magnesium stearate, and it is an amount of to add starch, regulates total amount to 380g, evenly mixed, be pressed into 1000, the bag film-coat promptly gets product Yixinshu tablet of the present invention.
Embodiment 5
Yixinshu tablet of the present invention, composed of the following components:
Radix Ginseng 230g 230g Radix Ophiopogonis
Fructus Schisandrae Chinensis 140g Radix Astragali 220g
Radix Salviae Miltiorrhizae 275g Rhizoma Chuanxiong 140g
Fructus Crataegi 230g microcrystalline Cellulose 50g
Magnesium stearate 2.5g starch is an amount of.
Get Radix Ginseng and pulverize, cross 100 mesh sieves, use pulsation vacuum sterilizer at 134 ℃, sterilization is standby after 1 hour down for 0.21Mpa; Get Fructus Schisandrae Chinensis, Radix Salviae Miltiorrhizae and add 5 times of amount 85% alcohol reflux 2 times, 3 hours for the first time, 1.5 hours for the second time, filter, merging filtrate is at 50 ℃, decompression recycling ethanol under the-0.08Mpa, and filtrate is concentrated into relative density 1.12～1.15 (20 ℃), pure extractum; Radix Ophiopogonis, the Radix Astragali, Rhizoma Chuanxiong, Fructus Crataegi are added 8 times of water gagings to be decocted 2 times, 2.5 hours for the first time, 1.5 hours for the second time, collecting decoction, filter, filtrate is concentrated into about 650ml, adds equivalent 85% ethanol, after fully stirring, standing over night, filter, filtrate is at 70 ℃, under-the 0.08Mpa decompression recycling ethanol and be concentrated into relative density 1.30～1.36 (80 ℃) the water extracted immersing paste; After above-mentioned two kinds of extractum merging, add above-mentioned Radix Ginseng fine powder, and add microcrystalline Cellulose, mix homogeneously is crossed 16 mesh sieve wet granulations with 80% ethanol, and 50 ℃ dry down, cross 20 mesh sieve granulate, dried granule adds magnesium stearate, and it is an amount of to add starch, regulates total amount to 380g, evenly mixed, be pressed into 1000, the bag film-coat promptly gets product Yixinshu tablet of the present invention.
Claims (4)
1. Yixinshu tablet is characterized in that composed of the following components:
Radix Ginseng 150～250g 150～250g Radix Ophiopogonis
Fructus Schisandrae Chinensis 95～150g Radix Astragali 150～250g
Radix Salviae Miltiorrhizae 240～285g Rhizoma Chuanxiong 95～150g
Fructus Crataegi 150～250g microcrystalline Cellulose 20～60g
Magnesium stearate 1～3g starch is an amount of.
2. Yixinshu tablet according to claim 1 is characterized in that composed of the following components:
Radix Ginseng 180～230g 180～230g Radix Ophiopogonis
Fructus Schisandrae Chinensis 100～140g Radix Astragali 170～220g
Radix Salviae Miltiorrhizae 250～275g Rhizoma Chuanxiong 100～140g
Fructus Crataegi 180～230g microcrystalline Cellulose 30～50g
Magnesium stearate 1.5～2.5g starch is an amount of.
3. Yixinshu tablet according to claim 2 is characterized in that composed of the following components:
Radix Ginseng 200g 200g Radix Ophiopogonis
Fructus Schisandrae Chinensis 133g Radix Astragali 200g
Radix Salviae Miltiorrhizae 267g Rhizoma Chuanxiong 133g
Fructus Crataegi 200g microcrystalline Cellulose 40g
Magnesium stearate 2g starch is an amount of.
4. according to claim 1,2 or 3 described Yixinshu tablets, it is characterized in that it is a tablet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010135024 CN101804152A (en) | 2010-03-23 | 2010-03-23 | Yixinshu tablet |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010135024 CN101804152A (en) | 2010-03-23 | 2010-03-23 | Yixinshu tablet |
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| Publication Number | Publication Date |
|---|---|
| CN101804152A true CN101804152A (en) | 2010-08-18 |
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| CN 201010135024 Pending CN101804152A (en) | 2010-03-23 | 2010-03-23 | Yixinshu tablet |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103784726A (en) * | 2014-01-27 | 2014-05-14 | 海南葫芦娃制药有限公司 | Heart relaxing tablet and preparation method thereof |
| CN105267694A (en) * | 2015-11-16 | 2016-01-27 | 刘振东 | Healthcare ginseng tea for conditioning coronary heart diseases |
| CN105311364A (en) * | 2014-07-30 | 2016-02-10 | 陈立云 | Chinese herbal compound for treating pulmonary heart disease |
| CN111388594A (en) * | 2020-04-21 | 2020-07-10 | 广东先通药业有限公司 | Extraction and quality identification method of effective components of Yixinshu tablet composition |
| CN111467429A (en) * | 2020-05-12 | 2020-07-31 | 徐文争 | Pulse-invigorating pill and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1814170A (en) * | 2005-12-15 | 2006-08-09 | 贵州信邦制药股份有限公司 | Medicinal drop pills for treating cardiovascular disease and preparing method |
| CN101088546A (en) * | 2006-06-13 | 2007-12-19 | 葛浩斌 | Heart-benefiting Yixinshu micropill and its prepn process |
-
2010
- 2010-03-23 CN CN 201010135024 patent/CN101804152A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1814170A (en) * | 2005-12-15 | 2006-08-09 | 贵州信邦制药股份有限公司 | Medicinal drop pills for treating cardiovascular disease and preparing method |
| CN101088546A (en) * | 2006-06-13 | 2007-12-19 | 葛浩斌 | Heart-benefiting Yixinshu micropill and its prepn process |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103784726A (en) * | 2014-01-27 | 2014-05-14 | 海南葫芦娃制药有限公司 | Heart relaxing tablet and preparation method thereof |
| CN103784726B (en) * | 2014-01-27 | 2017-06-13 | 海南葫芦娃药业集团股份有限公司 | Yixinshu tablet and preparation method thereof |
| CN105311364A (en) * | 2014-07-30 | 2016-02-10 | 陈立云 | Chinese herbal compound for treating pulmonary heart disease |
| CN105267694A (en) * | 2015-11-16 | 2016-01-27 | 刘振东 | Healthcare ginseng tea for conditioning coronary heart diseases |
| CN105267694B (en) * | 2015-11-16 | 2019-02-26 | 刘振东 | A kind of ginseng health care tea improving coronary heart disease |
| CN111388594A (en) * | 2020-04-21 | 2020-07-10 | 广东先通药业有限公司 | Extraction and quality identification method of effective components of Yixinshu tablet composition |
| CN111467429A (en) * | 2020-05-12 | 2020-07-31 | 徐文争 | Pulse-invigorating pill and preparation method thereof |
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Open date: 20100818 |