CN101793656B - Method for testing decocting rate of traditional Chinese medicine decoction - Google Patents
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Abstract
The invention discloses a method for testing the decocting rate of traditional Chinese medicine decoction, which relates to the technical field of decoction of the traditional Chinese medicine decoction, in particular to the test on the decocting rate of the traditional Chinese medicine decoction. Through carrying out combined tests of the water consumption, the decoction temperature, the heat power of strong heating fire, the heat power of slow fire, the decoction time of the slow fire and the like during the decoction process of the traditional Chinese medicine decoction, the contents of standard extract and decoction extract are measured, the decocting rate of the traditional Chinese medicine decoction is calculated, so the influence on the decocting rate of the traditional Chinese medicine decoction exerted by the water consumption, the decoction temperature, the heat power of the strong heating fire, the heat power of the slow fire, the decoction time of the slow fire, medicinal material forms, structures of decoction utensils and technical characteristics can be evaluated, and the quality level of the decoction also can be calculated. The invention can be applied to evaluate the decoction technique of the traditional Chinese medicine decoction, the decoction utensil and the decoction quality, and can work out different decocting rate and decoction technique requirements according to different traditional Chinese medicine decoction, so the therapeutic effect of the traditional Chinese medicine decoction can be ensured or improved through decocting the traditional Chinese medicine according to the decocting rate and the decoction technique requirements.
Description
Technical field:
The traditional Chinese herbal decoction that the present invention relates to Chinese medicine preparation technology category decocts technical field, or relates to the traditional Chinese herbal decoction decoction of traditional Chinese medicine, science of Chinese materia medica technical field, relates in particular to the test method of traditional Chinese herbal decoction decoction rate.
Background technology:
Traditional Chinese herbal decoction is positioned at first of the traditional Chinese medicine formulation, is the prescription medicine and main formulation of the traditional Chinese medical science.Traditional Chinese herbal decoction is obtained the decoction of medicinal ingredients of soup part gained by prepared slices of Chinese crude drugs boiling, and technical term is a decoction.The decoction that decocts out with the prepared slices of Chinese crude drugs directly lets the patient take, and can treat various diseases.The traditional Chinese medical science is attached great importance to the decocting method and the quality of traditional Chinese herbal decoction, has formed a whole set of effective traditional Chinese herbal decoction decocting method over the past thousands of years.In March, 2009, State Administration of Traditional Chinese Medicine printed and distributed " medical institutions' Chinese medicine boil medicine chamber management regulation ", wherein regulation: thing to be boiled medicine should soak in advance, and soak time generally is no less than 30 minutes.Water consumption when decocting beginning generally was advisable to soak powder 2-5 centimetre, and what flower, grass type medicine or decocting time were long should add water as one feels fit.Every dose of medicine is general to decoct twice, with two boil medicine juice mix after packing again.Decocting time should cure mainly according to the function of prescription with the effect of medicine to be confirmed.After boiling, general medicine decocted again 20-30 minute; Type of inducing sweat, heat-clearing class, aromatics medicine should not be fried in shallow oil for a long time, decoct after boiling 15-20 minute again; After the nourishing medicine boils earlier with high heat, use slow fire instead and fried in shallow oil slowly about 40-60 minute.The decocting time that medicament second is fried in shallow oil should slightly shorten than first time of frying in shallow oil.To stir spice 2-3 time in the process of boiling medicine.Stirring the apparatus of spice should be advisable with the club of material such as pottery, stainless steel, copper, has stirred should clean behind the spice and has stirred next spice again; Or the like.The decoction quality of traditional Chinese herbal decoction mainly guarantees according to method or experience is judged.Aspect the method assurance, as the method for pressing afore mentioned rules decocts decoction, can guarantee that traditional Chinese herbal decoction decocts quality.Aspect the experience judgement, main look through decoction, flavor etc. are judged the quality of decoction quality, as are accustomed to so-called " bitter to the taste good medicine ", and promptly bitter has been medicine; What also have that decoction is saturate, taste is heavy has all thought medicine traditionally.
Along with modernization industrial development and the development of modernized Chinese medicine and the social demand of continuous expansion, the artificial decoction has been difficult to satisfy present demand, so the traditional Chinese herbal decoction decoction develops into the decoction of robotization decocting machine gradually from the conventional artificial decoction.Adopt decocting machine to decoct, can improve decoction efficient effectively, and have advantages such as convenient, fast, but can the quality that in the efficient decocting herb decoction of robotization in batches, guarantee decoction become crucial problem.Present many decocting machines also all propose; Compare with the traditional decoction mode that can to improve effective constituent fried, a kind of automatic boiling-machine is provided, propose to adopt closed high pressure to decoct like the patent No. 00259663.6; Can effective constituent in the medicine is fried fully, the drug rate is high.The patent No. 200420041962.3 provides a kind of and proposes the use of this decocting machine with the automatic machine for decocting Chinese traditional herb medicines that stirs and clean, and has improved the decocting rate of middle pharmaceutically active ingredient.Though these decocting machines all propose to improve the decocting rate of effective constituent in the medicine, the decocting rate that does not but provide a kind of effective method to check decocting machine can not be estimated the decoction quality of decocting machine accurately, quantitatively.
Therefore need come to check accurately and estimate the decoction quality of decocting machine or decocting method through a kind of traditional Chinese herbal decoction quality evaluating method.The Liang Weiqing of Inst. of Traditional Chinese Medicine, Zhejiang Prov etc.; In " boiling machine is boiled medicine and the boil medicine comparison of decocting rate of classic method " literary composition; Detect decocting rate through measuring the content that decocts the index components (as: general flavone, TA etc. in the decoction) in the decoction of back, estimate the decoction quality with the decocting rate of these index components.This detection method can reflect to a certain extent that traditional Chinese herbal decoction decocts quality, but not enough is, traditional Chinese herbal decoction is normally mixed to decoct by multi-component medicine and formed, and not only comprises these index components in the decoction, also comprises many other effective constituents.Main is; Traditional Chinese herbal decoction is extremely personalized prescription medicine, and different people is suffered from the prescription of same disease can be different, and the prescription that same people, same disease open in different times or the different traditional Chinese medical science also can be different; The characteristics of the traditional Chinese medical science are diagnosis and treatment based on an overall analysis of the illness and the patient's condition, suit the remedy to the case; Medicine changes, and the index components in the medicine changes thereupon, and index components is difficult to estimate the quality level of Chinese medicine.The Chen Yingchun of Hebei Prov. Traditional Chinese Medicine Hospital Pharmacy etc.; In " comparative study of Shenghua Tang tradition decoction and boiling machine decoction " literary composition; Identical medicine is carried out traditional decoction decoction and boiling machine decoction respectively; In the decoction that uses after diverse ways decocts, measure the 20mL soup respectively, measure wherein contained extract content and compare, the result shows that the fried soup extract content of boiling machine is higher.This through measuring the good and bad method of extract content evaluation decoction decocting method; It is a kind of relatively method; Can the decoction effect of different decoction methods be compared, but the test and the evaluation method of the traditional Chinese herbal decoction quality of complete, standard are not provided, test findings possibly vary with each individual.
Summary of the invention:
The test method that the purpose of this invention is to provide a kind of traditional Chinese herbal decoction decoction rate is with the quality of scientific evaluation traditional Chinese herbal decoction decocting method and the quality level of traditional Chinese herbal decoction.
The scheme of technical solution problem of the present invention is: a kind of traditional Chinese herbal decoction method for testing decocting rate; Adopt the water-soluble extractives determination method; Theoretical maximum through measuring medicine water-soluble extractives content is the standard extract content; Medicine water-soluble extractives content when measure adopting a certain actual decocting method then decocts extract content, calculates traditional Chinese herbal decoction decoction rate according to traditional Chinese herbal decoction decoction rate expression formula again, and concrete steps and method are following:
1) raw material is prepared: take by weighing the medicine materical crude slice that total amount is 20～400g medicine materical crude slice or at least 1 dose of prescribed dose according to decoction prescription proportioning; Note is made raw material A; Take by weighing the medicine materical crude slice that total amount is 200～5000g medicine materical crude slice or 1～20 dose of prescribed dose by raw material A same decoction prescription proportioning and same batch medicine materical crude slice in addition, note is made raw material B.The form of said medicine materical crude slice is for pressing " medicine materical crude slice or the configuration of medicinal materials of the concocted specification defined that one one of Chinese pharmacopoeia or relevant department issue; When the decoction prescription is the single medicine materical crude slice; Raw material A takes by weighing by 20g, and raw material B takes by weighing by 200～5000g according to the volume that decocts utensil, when the decoction prescription is compound; Raw material A takes by weighing by the potion recipe quantity, and raw material B takes by weighing by 1～20 dose of prescribed dose merging according to the volume that decocts utensil.
2) the standard extract content is measured: raw material A is crushed to masher all sieves or No. three sieves through No. two, must not be through the powder of No. seven sieves above 20%, and screen size is with reference to " the regulation that Chinese pharmacopoeia is an one; And mix; Sampling 2～10g, according to experience, extract content high person take a morsel; The low person of extract content gets volume, precision weighing (m
A1), put appropriate containers, like the glass conical flask, add the water of 15～60 times of content of starting materials A weight, maximum extract content is as the criterion amount of water in the medicine determining, and can carry out trial test in case of necessity to confirm amount of water, delicate metering amount of water (V
A1, mL), be heated to boiling; And keeping little 0.2～2h that boils, little time of boiling, maximum extract content was as the criterion in the medicine determining, and can carry out trial test in case of necessity to confirm little boiling the time; Put cold back water and supply the water yield that subtracts mistake, filtering extracting liquid, precision is measured soup 15～50mL (V
A2), the solid content in the drying and dehydrating taking liquid, precision weighing (m
A2), be calculated as follows the standard extract content:
3) decocting extract content measures: with raw material B precision weighing (m
B1), put suitable traditional Chinese herbal decoction and decoct utensil, add water n (weight of the raw material B of n=1.5～10 times amount precision weighing),, delicate metering amount of water (V
B1, mL), intense fire decocts; The intense fire firepower is the soup temperature rise speed P=2～15 ℃/min from the boiling of room temperature to soup; By slow fire boiling 0.2～1.5h, the slow fire firepower is the heating power that is equivalent to soup temperature rise speed P=0.1～2 ℃/min before the soup boiling during soup boiling, puts cold back water and supplies the water yield that subtracts mistake; Filtering extracting liquid, precision are measured soup 15～100mL (V
B2), the solid content in the drying and dehydrating taking liquid, precision weighing (m
B2), be calculated as follows the decoction extract content:
4) the standard extract content and the decoction extract content that go out according to aforementioned calculation are calculated as follows traditional Chinese herbal decoction decoction rate:
The optimization amount of water that described standard extract content is measured is 20～30 times of drug weight, and the optimization amount of water that decocts extract content mensuration is 2～5 times of drug weight.
The filter screen that described filtering extracting liquid uses is 60 orders or above filter screen.
Beneficial effect of the present invention is:
(1) providing a kind of is the traditional Chinese herbal decoction method for testing decocting rate of index with the water-soluble extractives.With the water-soluble extractives is index; Both followed the principle that the traditional Chinese herbal decoction water decocts; The actual decoction process of test method and decoction has the similarity of height; Also meet traditional Chinese medicine and have the attribute and the theory of " four gas ", " five tastes ", " return through ", " trend ", through experiences such as the color of decoction, taste being judged the decoction quality compares, have the characteristics of objective, quantification, science with at present; With judge that through the index components content that detects in the decoction decoction quality gets method and compares, also have simple, easy-operating characteristics.
(2) providing a kind of is the traditional Chinese herbal decoction method for testing decocting rate of basic point with the standard extract content.With the standard extract content is basic point; Two indexs of decoction extract content that provides and decoction decocting rate; In order to estimate traditional Chinese herbal decoction and to decoct quality level, not only expressed the quality level of traditional Chinese herbal decoction objectively, can also estimate the technology level that traditional Chinese herbal decoction decocts.
(3) a kind of traditional Chinese herbal decoction method for testing decocting rate of complete, standard is provided, has been convenient to set up the evaluation criterion of traditional Chinese herbal decoction decocting process and quality level.The present invention measures, decocts extract content mensuration, traditional Chinese herbal decoction decoction rate computing method etc. to the raw material preparation, the standard extract content that relate in the Chinese medicine decoction decocting rate test method and carries out scientific design and planning; Content intact, standard, easy to operate; The test findings error is little, can be used as the evaluation criterion of traditional Chinese herbal decoction decocting process and decoction quality level.Especially with intense fire, slow fire, slow fire boiling time as decoction decocting rate content of the test, comparatively intactly expressed the factors that influence traditional Chinese herbal decoction decoction rate, improved practicality, the science of this method.
(4) utilization traditional Chinese herbal decoction method for testing decocting rate provided by the invention, significant for the development traditional Chinese medicine.The traditional Chinese herbal decoction decocting method of current application mainly is to have inherited classic method, for new technology, The application of new technique because the evaluation criterion of deficiency in objective, science, quantification makes traditional Chinese herbal decoction decoctions technology and modern civilization have a certain distance.For example: time, temperature, firepower, water consumption, medicinal material or the medicine materical crude slice form etc. that traditional Chinese herbal decoction decocts are all confirmed according to experience or traditional habit; But not the science result who on the basis of experiment, obtains, one of its reason is exactly lack of scientific, complete, easy-operating evaluation criterion.The factor that influences traditional Chinese herbal decoction decoction quality level comprises decocting time, decoction temperature, decoction firepower (intense fire decocts, slow fire is little boils), water consumption, medicinal material or medicine materical crude slice form, the structure that decocts utensil and technical characteristic etc.; How accurately to estimate of the influence of these factors to the Chinese medicine decoction decocting; Be related to technological innovation and development that traditional Chinese herbal decoction decocts, enforcement of the present invention will promote the technical progress of this technical field.
(5) help improving the confidence level of Chinese medicine, promote the development of traditional Chinese medicine.At present to the evaluation of traditional Chinese herbal decoction mainly according to sense organ contents such as color, smell, tastes; But not objective quantizating index; This understands modern science and cultural people for major part, becomes to be difficult for understanding and approval, and tracing it to its cause is the standard of deficiency in objective and quantification.It has been a kind of production run of personalized Chinese medicine in fact that traditional Chinese herbal decoction decocts, since be that pharmacy procedure just need be produced by the mode of modern pharmaceutical technology.Enforcement of the present invention will become the basis that technical management is carried out in personalized Chinese medicine production, and scientific management production run and product quality, and then the confidence level of raising Chinese medicine promote the development of traditional Chinese medicine.
Embodiment
Be example below with the Sijunzi Tang, use boiling machine to decoct decoction, enforcement of the present invention is further described.
According to " Chinese pharmacopoeia one one 2005 editions, the consisting of of potion Sijunzi Tang: genseng (9g), the bighead atractylodes rhizome (9g), Poria cocos (9g), honey-fried licorice root (6g).
1, sampling
Take by weighing 1 dose of Sijunzi Tang prescription medicine materical crude slice (33g), note is made raw material A, and other takes by weighing 7 doses of Sijunzi Tang prescription medicine materical crude slice (231g), and note is made raw material B.
2, specimen preparation
With masher raw material A is pulverized, chien shih medicinal powder can be no more than 20% through the powder of No. seven sieves all through No. two sieves when control was pulverized, and mixed after the pulverizing.
3, the standard extract content is measured
Accurately from raw material A, take by weighing sample 4g (m
A1), place the 250mL conical flask, delicate metering 100mL water (V
A1), place conical flask and sample mixed, accurately claim to decide conical flask general assembly (TW) (m
1, g), leave standstill about 1h, connect reflux condensing tube (with reference to " and Chinese pharmacopoeia), be heated to boiling after, move into immediately in the boiling water bath, keep little 1h that boils.After being cooled to room temperature, get conical flask, the conical flask outside is dried, accurately claim to decide conical flask general assembly (TW) (m
2, g), water is supplied the weight that subtracts mistake and is made m
2=m
1, shake up, there is the device for drying and filtering of 80 mesh filter screens to filter with device, precision is measured filtrating 25mL (V
A2), (weight of evaporating dish is m to place the evaporating dish that is dried to constant weight
3, g), move in 105 ℃ ± 2 ℃ the thermostatic drying chamber, dry 3 hours, move into then and cool off 30min in the exsiccator, accurately claim to decide weight (m rapidly
4, g), dry solid content weight is m in the soup
A2=m
4-m
3, be calculated as follows the standard extract content.
4, decocting extract content measures
Decocting extract content to different test objectives measures; Like water consumption, decoct temperature, intense fire firepower, slow fire firepower, slow fire boiling time, medicinal material or medicine materical crude slice form, the structure that decocts utensil and technical characteristic etc. different; The capital influence decocts the content of extract; No matter be the mensuration to extract content in the decoction, still estimate different decocting processes, its main test method is identical.Whenever carry out a test and use a raw material B separately.
Accurate raw materials weighing B (m
B1), place normal pressure to decoct utensil (it is 100 ℃ that this enforcement row decoct temperature), delicate metering 693mL water (V
B1, mL) (this enforcement row are got the water consumption of 10 times of drug weight), accurately general assembly (TW) (the M of medicine and water decided in title
1, g), placing the decoction utensil, the about 60min of soak medicine decocts to fluid temperature with the firepower of P=4 ℃/min and to reach 98 ℃, and control decocts the utensil heating power, makes the temperature rise speed of soup rise to 100 ℃ with 0.5 ℃/min speed, and continues to decoct 30min.After being cooled to room temperature, the medicine and the soup that decoct in the utensil all take out, and accurately claim to decide weight (M
2, g), water is supplied the weight that subtracts mistake and is made M
2=M
1, stir, there is the device for drying and filtering of 80 mesh filter screens to filter with device, precision is measured filtrating 25mL (V
B2), (weight of evaporating dish is M to place the evaporating dish that is dried to constant weight
3, g), move in 105 ℃ ± 2 ℃ the thermostatic drying chamber, dry 3 hours, moved in the exsiccator cooling then 30 minutes, accurately claim to decide weight (M rapidly
4, g), dry solid content weight is m in the soup
B2=M
4-M
3, be calculated as follows the decoction extract content.
5, calculate the decoction rate
Standard extract content and decoction extract content according to aforementioned calculation goes out are calculated as follows traditional Chinese herbal decoction decoction rate.
Claims (3)
1. a traditional Chinese herbal decoction method for testing decocting rate is characterized in that adopting the water-soluble extractives determination method, and concrete steps and method are following:
1) raw material is prepared: take by weighing the medicine materical crude slice that total amount is 20～400g medicine materical crude slice or at least 1 dose of prescribed dose according to decoction prescription proportioning; Note is made raw material A; Take by weighing the medicine materical crude slice that total amount is 200～5000g medicine materical crude slice or 1～20 dose of prescribed dose by raw material A same decoction prescription proportioning and same batch medicine materical crude slice in addition, note is made raw material B.
2) the standard extract content is measured: raw material A is crushed to all through No. two sieves or No. three sieves, and the powder through No. seven sieves must not be above 20%, and mixes, the 2～10g that takes a sample, and precision weighing is designated as m
A1, put appropriate containers, add the water of 15～60 times of content of starting materials A weight, the delicate metering amount of water is designated as V
A1, unit is mL, is heated to boiling, and keeps little 0.2～2h that boils, put cold back water and supply the water yield that subtracts mistake, and filtering extracting liquid, precision is measured soup 15～50mL, is designated as V
A2, the solid content in the drying and dehydrating taking liquid, precision weighing is designated as m
A2, be calculated as follows the standard extract content:
3) decocting extract content measures: with raw material B precision weighing, be designated as m
B1, put suitable traditional Chinese herbal decoction and decoct utensil, add water n, the weight of the raw material B of n=1.5～10 times amount precision weighing, the delicate metering amount of water is designated as V
B1, unit is mL, intense fire decocts; The intense fire firepower is the soup temperature rise speed P=2～15 ℃/min from the boiling of room temperature to soup, and by slow fire boiling 0.2～1.5h, the slow fire firepower is the heating power that is equivalent to soup temperature rise speed P=0.1～2 ℃/min before the soup boiling during soup boiling; Put cold back water and supply the water yield that subtracts mistake; Filtering extracting liquid, precision are measured soup 15～100mL, are designated as V
B2, the solid content in the drying and dehydrating taking liquid, precision weighing is designated as m
B2, be calculated as follows the decoction extract content:
4) be calculated as follows traditional Chinese herbal decoction decoction rate:
2. a kind of traditional Chinese herbal decoction method for testing decocting rate according to claim 1 is characterized in that the optimization amount of water that the standard extract content is measured is 20～30 times of drug weight, and the optimization amount of water that decocts extract content mensuration is 2～5 times of drug weight.
3. a kind of traditional Chinese herbal decoction method for testing decocting rate according to claim 1 is characterized in that the filter screen that described filtering extracting liquid uses is 60 orders or above filter screen.
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| CN102749946A (en) * | 2011-04-20 | 2012-10-24 | 杭州海善制药设备有限公司 | Traditional Chinese medicine decoction decocting fire power measurement and control method for showing fire power by temperature rising speed |
| CN105380790B (en) * | 2015-11-25 | 2019-05-03 | 新疆医科大学附属中医医院 | A method of determining closed disjunctor boiling machine Herb-decocting Method amount of water |
| CN105319144A (en) * | 2015-12-09 | 2016-02-10 | 李琛 | Digital display tensile-sensitive hole ratio tester and detecting method thereof |
| CN109975166A (en) * | 2019-04-17 | 2019-07-05 | 甘肃农业大学 | A kind of improved method of hot dipping measurement Chinese herbal medicine extract |
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|---|---|---|---|---|
| CN2707260Y (en) * | 2004-05-24 | 2005-07-06 | 陕西科技大学 | Automatic traditional Chinese medicine decocting machine with stirring and cleaning functions |
| WO2006073154A1 (en) * | 2005-01-07 | 2006-07-13 | Eisai R&D Management Co., Ltd. | Medicinal composition and process for producing the same |
-
2009
- 2009-12-31 CN CN2009101559695A patent/CN101793656B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2707260Y (en) * | 2004-05-24 | 2005-07-06 | 陕西科技大学 | Automatic traditional Chinese medicine decocting machine with stirring and cleaning functions |
| WO2006073154A1 (en) * | 2005-01-07 | 2006-07-13 | Eisai R&D Management Co., Ltd. | Medicinal composition and process for producing the same |
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| Publication number | Publication date |
|---|---|
| CN101793656A (en) | 2010-08-04 |
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