CN101792411A - New method for combining ethyl sulfonamide - Google Patents
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Abstract
The invention belongs to the field of pharmaceutical chemicals and discloses a new method for combining ethyl sulfonamide; in the invention, indoline is used as starting material, and the target compound: N-methyl-1H-benzpyrole-5-ethyl sulfonamide is obtained by the steps of benzyl protection, formylate, condensation with N-methyl methanesulfonamide, hydrogenation reduction, debenzyl and oxidation and the like; in the combining route, the raw material is easily to obtain, the process is simple, the yield is high, the operation is convenient, the environment is friendly, the disadvantages that the raw material preparation is difficult and the regent cost is overhigh in the prior art are overcome, and the method has industrial application value.
Description
Technical field
The invention belongs to field of medicine and chemical technology, relate to a kind of novel method of combining ethyl sulfonamide, be specifically related to the method for a kind of synthetic N-Methyl-1H-indole-5-ethyl sulfonamide and be used for the compound of synthetic N-Methyl-1H-indole-5-ethyl sulfonamide.
Background technology
Naratriptan is the s-generation triptan antimigraine of the plain prestige Kanggong department of Ge Lai (Glaxo Wellcome) exploitation, and curative effect is obvious.Its chemistry N-methyl-3-(1-methyl-4-piperidyl) by name-1H-indoles-5-ethyl sulfonamide (3), its synthetic method is in patent GB2208646 open (corresponding to patent EP303507 and US4997841) first.
Disclosed data shows that the synthetic route of naratriptan has two big classes totally nine routes.Wherein a big class is the b-sulfonamide derivative that earlier synthetic phenyl ring replaces, and carries out indoles closed loop and and the condensation of N-methylpiperidone again.The patent that relates to these class methods has US4997841, WO2006/010079, WO2008/056378 and document (Heterocycles, 2003,60,2441).The synthetic starting raw material of these class methods does not have commercialized supply, and step is long, and yield is low.Close the reagent that to use costliness in the ring process at indoles, or the reagent that pollutes than overall situation is arranged, be difficult to suitability for industrialized production and commercialization such as tindichloride, titanium tetrachloride etc.
The synthetic route of another big class naratriptan is to introduce the ethyl sulfonamide group on indole ring, obtains key intermediate N-Methyl-1H-indole-5-ethyl sulfonamide (2) or derivatives thereof, again with the condensation of N-methylpiperidone.The patent that relates to these class methods has US4997841, US5786473, CN200410093115.These class methods are main method of current suitability for industrialized production naratriptan.According to the difference of ethyl sulfonamide group introducing method, can be divided into two classes again.
The method of patent US4997841 and patent US5786473 is the Heck reaction by N-methyl ethylene sulphonamide (12) and 5-bromo indole (13), and hydrogenating reduction is introduced ethyl sulfonamide group (reaction formula 3) then.One of raw material of Heck reaction no commercialized supply of compound (12) is easy to polymerization in this route, the preparation difficulty.Another starting compound (12) need come from the indoles preparation by four-step reaction, and price is more expensive.The Heck reaction needed is used expensive reagent palladium and three (o-methyl-phenyl-) phosphine in addition.This route cost is higher.
Reaction formula 3
The method of patent CN200410093115 is condensation under alkaline condition by the N-methyl Toluidrin (7) of radical protection and 5-formaldehyde indoles (14), and hydrogenating reduction is introduced ethyl sulfonamide group (reaction formula 4) then.Compound in this route (7) is cheap and easy to get, and the condensation reaction productive rate is good, does not need violent condition and expensive reagent, is a synthetic route preferably.Its defective is that compound (14) cost is higher.
Reaction formula 4
Patent CN200410093115 discloses the method (reaction formula 5) for preparing compound (14).With 5-bromo indole (13) is raw material, goes through steps such as cyaniding, reduction and radical protection.But the starting compound in this route (13) still needs to come from the indoles preparation by four-step reaction, cyanogenation needs the poisonous reagent cuprous cyanide of microwave condition, equimolar amount and more expensive solvent N-Methyl pyrrolidone, cost height not only, also have serious pollution problem, be not suitable for suitability for industrialized production.
Reaction formula 5
Comprehensive above background technology, N-Methyl-1H-indole-5-ethyl sulfonamide (2) are the key intermediates during naratriptan (Naratriptan) synthesizes.Still do not have so far that a kind of technology of preparing or route can satisfy comprehensively that raw material is cheap and easy to get, step is short, higher, easy to operate, the eco-friendly industrialization of productive rate and commercialization requirement, require further improvement.
Summary of the invention
The objective of the invention is to above-mentioned deficiency at prior art; the novel method of a kind of synthetic N-Methyl-1H-indole-5-ethyl sulfonamide is provided; make the preparation of N-Methyl-1H-indole-5-ethyl sulfonamide avoid using expensive reagent such as N-methyl ethylene sulphonamide; palladium; three (o-methyl-phenyl-s); 2; 3-two chloro-5; 6-dicyano-1; the 4-benzoquinones; the N-crassitude; methyl iodide; 5-bromo indole and 5-formaldehyde indoles etc.; avoid using the reagent such as the cuprous cyanide of severe toxicity; avoid using the reagent such as the sodium Metal 99.5 of safety and environment hidden danger; tindichloride and titanium tetrachloride etc. are avoided the processing condition of harshness such as the low temperature of liquefied ammonia; protection of inert gas; definitely anhydrous etc.
Another object of the present invention provides a kind of new compound that is used for synthetic N-Methyl-1H-indole-5-ethyl sulfonamide.
Purpose of the present invention can be achieved through the following technical solutions:
The synthetic method of compound disclosed in this invention (2) is shown in reaction formula 1.With indoline cheap and easy to get is starting raw material; through radical protection, Vilsmeier-Haack formylation reaction, with the condensation of N-methyl Toluidrin, the reduction of two key, deprotection base, 6 elementary reactions of oxidation of tertbutyloxycarbonyl protection, can obtain N-Methyl-1H-indole-5-b-sulfonamide compound (2).
6 elementary reactions itself all can adopt prior art among the present invention, the reaction conditions that is preferably as follows:
Nitrogen-atoms on the described indoline (4) is with the protection of N-alkyl blocking group, employing be nitrogen-atoms radical protection technology commonly used in organic synthesis, preferred benzyl protection.Wherein 1.0～1.5 moles benzyl chlorine or benzyl bromine are used in the benzyl protection reaction; with N; dinethylformamide (DMF) is a solvent; in the presence of salt of wormwood; obtained compound (5) in 2～4 hours in 60～120 ℃ of reactions, wherein the mol ratio of indoline and benzyl chlorine or benzyl bromine and salt of wormwood is 1: 1.0～1.5: 1.0～1.5.
Described formylation reaction is the Vilsmeier-Haack formylation reaction: with N; dinethylformamide is a solvent; dripping phosphorus oxychloride formation Vilsmeier reagent below-10～5 ℃; be warming up to 60～120 ℃ and compound (5) reaction 3～10 hours again, wherein compound (5) is 1: 1～3 with the mol ratio of phosphorus oxychloride.
The condition of compound (6) and N-methyl-N-tertbutyloxycarbonyl Toluidrin (7) condensation is: be solvent with the anhydrous tetrahydro furan, in the presence of sodium tert-butoxide or potassium tert.-butoxide, compound (6) and compound (7)-50 ℃ to system reflux temperature insulation reaction 5-10 hour, wherein compound (6) is 1: 1～4: 1～1.5 with the mol ratio of sodium tert-butoxide or potassium tert.-butoxide and compound (7).In reaction process, the Boc blocking group on the nitrogen is also sloughed.
Described compound (7) is to use the tert.-butoxy formic anhydride that nitrogen-atoms in the N-methyl Toluidrin is carried out radical protection and obtains; reaction conditions is that N-methyl Toluidrin is in methylene chloride; with the 4-Dimethylamino pyridine is catalyzer; obtained compound (7) in 4～6 hours with the reaction of tert.-butoxy formic anhydride under 5～40 ℃ of temperature, wherein the mol ratio of N-methyl Toluidrin and 4-Dimethylamino pyridine and tert.-butoxy formic anhydride is 1: 0.01～0.05: 1.0～1.5.
By the reaction of reduction and deprotection base, compound (8) is converted into compound (11).This conversion can first reducing compound (8) two keys obtain compound (10), the deprotection base obtains compound (11) again.The protecting group that also can take off compound (8) earlier obtains compound (9), restores two keys and obtains compound (11).Two key reduction and debenzylation can also carry out with one step of mode of " one kettle way " or batch charging.
Described reduction reaction adopts the method for Pd/C shortening, reaction conditions is: catalyzer is that the weight percent content of Pd is 5～20% Pd/C, catalyst levels is 10～30% of a hydrogenation substrate weight, solvent is methyl alcohol, ethanol, ethyl acetate or tetrahydrofuran (THF), hydrogen pressure can be selected between 0.1～2.0MPa, temperature of reaction is 20～80 ℃, and the reaction times is 5～12 hours.
Described deprotection reaction adopts Pd/C or Pd (OH)
2The method of/C catalytic hydrogenolysis, preferred Pd (OH)
2The method of/C catalytic hydrogenolysis.
Pd (OH)
2The condition of/C catalytic hydrogenolysis is: catalyzer is that the weight percent content of Pd is Pd (OH)/C of 5～20%, catalyst levels is 10～30% of a hydrogenation substrate weight, solvent is methyl alcohol, ethanol, ethyl acetate or tetrahydrofuran (THF), hydrogen pressure can be selected between 0.1～2.0MPa, temperature of reaction is 20～80 ℃, and the reaction times is 5～12 hours.Pd/C or Pd (OH)
2The method product yield height of/C catalytic hydrogenolysis, purifying is easy, mild condition, catalyzer can reclaim and re-use, and is free from environmental pollution.
In the described oxidizing reaction, indoline derivative thing (11) dehydrogenation becoming indole derivatives (2).Described oxidizing reaction is a solvent with ethylene dichloride, ethyl acetate, methyl alcohol or ethanol, compound (11) is oxygenant with Manganse Dioxide, obtained compound (2) in 5-10 hour at 5～50 ℃ of temperature range internal reactions, wherein compound (11) is 1: 1～10 with the mol ratio of Manganse Dioxide.The use of can regenerating after reducing of solid manganese dioxide after the filtration, environmental pollution is little.
Be used for the new compound of synthetic N-Methyl-1H-indole-5-ethyl sulfonamide, this compound has following general formula:
Substituent R wherein
1For hydrogen atom, allyl group, benzyl or to methoxy-benzyl, substituent R
2Be N-methyl ethylene sulfoamido or N-methylethyl sulfoamido.
Described general formula compound (1) is preferred:
N-methyl isophthalic acid-benzyl-indoline-5-ethene sulphonamide, N-Methyl-1H-indole quinoline-5-ethene sulphonamide,
N-Methyl-1H-indole quinoline-5-ethyl sulfonamide N-methyl isophthalic acid-benzyl-indoline-5-ethyl sulfonamide
Or.
Raw material related among the preparation method of the present invention is commercially available product.
Unaccomplished matter of the present invention is the routine techniques in this area.
Beneficial effect of the present invention:
1, existing synthetic route all is to be parent nucleus with the indoles, introduces substituting groups at 5.And the present invention is to be parent nucleus with the indoline, and the feasibility of accurate control response location is provided, and behind 5 introducing sulfoamidos, becomes the indoline parent nucleus again and is the indoles parent nucleus, has kept the indoline parent nucleus in whole synthetic route, until final step.This makes that the side reaction of per step generation is less, the high and purification easily of yield.
2, the present invention has improved the method for introducing formyl radical at 5 greatly, and cost is descended greatly.Existing method needs the reaction of 7 steps altogether for the 5-formaldehyde indole derivatives that obtains can be used for the sulphonamide condensation.The present invention only 2 step reactions promptly obtains can be used for 5-formaldehyde indoline derivative thing with the sulphonamide condensation, and step is short, the yield height.
The use reagent costliness that has existed when 3, the present invention has overcome prior art for preparing N-Methyl-1H-indole-5-ethyl sulfonamide and naratriptan, severe toxicity is arranged, safety and environment are had hidden danger, processing condition harshness, the defective that feedstock production difficulty and cost are too high.Preparation route raw material of the present invention is cheap and easy to get, step is short, productive rate is higher, easy to operate, environmental friendliness, is fit to industrialization and commercialization.
Embodiment:
The present invention is further elaborated below in conjunction with embodiment.Be understood that the cited case is to understand content of the present invention for better, and should be considered as limiting the scope of the invention.
Embodiment 1
1.N-benzylindole quinoline (5) is synthetic
In the four-hole boiling flask of the 250ml that dropping funnel and thermometer are housed, and adding indoline (4) (50g, 0.42mol), K
2CO
3(70g 0.51mol) and DMF (120ml), stirs and is warming up to 100 ℃.Slow dropping benzyl bromine in 1 hour (75.42g, 0.44mol).After dropwising, insulation reaction reaction 3 hours, TLC shows that reaction finishes.Reaction solution is cooled to room temperature, in the impouring 1000ml water, stirs standing demix after 0.5 hour, tell lower black oily matter.Have solid through the stirring placement and separate out, use re-crystallizing in ethyl acetate, obtain compound (5) 80.12g, productive rate 91.3%.
2.N-benzyl-5-formaldehyde indoline (6) is synthetic
In the four-hole boiling flask of the 100ml that dropping funnel and thermometer are housed, add DMF (20ml), with ice-water bath system is cooled to below 5 ℃, drip POCl
3(20ml, 0.20mol).The control rate of addition makes temperature of reaction between-10～5 ℃.Dropwise the back and stirred 20 minutes, drip compound (5) (20g, DMF solution 20ml 0.096mol) again.Dropwise, stirring at room reaction 30 minutes, reheat to 80 ℃ reaction 3 hours, the TLC demonstration reacts completely.Reaction solution is cooled to room temperature, in the impouring 400ml mixture of ice and water, adds NaOH solution and transfers PH to be alkalescence, have solid to separate out, suction filtration washes filter cake with water, oven dry obtains compound (6) N-benzyl-5-formaldehyde indoline 17.65g, productive rate 77.6% with re-crystallizing in ethyl acetate.
The nuclear magnetic data of compound (6) N-benzyl-5-formaldehyde indoline is as follows:
1H-NMR (CDCl
3) 300MHz, δ (ppm): 3.07 (t, 2H, J=8.4Hz), 3.57 (t, 2H, J=8.6Hz), 4.42 (s, 2H), 6.47 (d, 1H, J=8.1Hz), 7.25～7.38 (m, 5H), 7.53～7.58 (m, 2H), 9.67 (s, 1H).
3.N-methyl-N-tertbutyloxycarbonyl Toluidrin (7) is synthetic
Input N-methyl Toluidrin in the four-hole bottle of 1000ml (55.0g, 0.50mol), catalyzer DMAP (1.5g, 0.012mol) with methylene dichloride 200ml, stirring at room 30 minutes.Stir and slowly drip tert.-butoxy formic anhydride (Boc) down
2O (119.0g, 0.55mol).Dropwise, kept stirring at room 3 hours, GC shows that reaction finishes.Steam methylene chloride, get compound (7) 101.3g, productive rate 94.6% (deducting catalyzer), purity 96.0% can be used for next step reaction without purifying.
4.N-methyl isophthalic acid-benzyl-indoline-5-ethene sulphonamide (8) is synthetic
In the four-hole bottle of 500ml, drop into compound (6) (10.0g, 0.042mol), compound (7) (9.0g, 0.046mol) and anhydrous THF (200ml), stirring at room 30min.(6.0g 0.063mol), stirs and is warming up to backflow, is incubated about 6 hours, and TLC shows that reaction finishes to drop into sodium tert-butoxide then in reaction flask.Reduce to room temperature, add 100ml water, stirred 30 minutes.Decompression steams organic solvent, has solid to separate out.Suction filtration, washing, oven dry, recrystallization obtains compound (8) N-methyl isophthalic acid-benzyl-indoline-5-ethene sulphonamide 9.5g, productive rate: 69.0%.
The nuclear magnetic data of compound (8) N-methyl isophthalic acid-benzyl-indoline-5-ethene sulphonamide is as follows:
1H-NMR (CDCl
3) 300MHz, δ (ppm): 2.64 (d, 3H, J=5.4Hz), 3.06 (t, 2H, J=8.4Hz), 3.60 (t, 2H, J=8.4Hz), 3.75 (m, 1H), 4.29 (s, 2H), 6.62 (d, 1H, J=14.4), 7.23～7.39 (m, 5H), 7.53～7.61 (m, 3H,), 7.64 (d, 1H, J=15.3).
5.N-Methyl-1H-indole quinoline-5-ethene sulphonamide (9) is synthetic
(38.2g, 0.10mol) with methyl alcohol 600ml, the weight percent that adds Pd is 10% Pd (OH) to drop into compound (8) in the hydrogenation still
2/ C catalyzer (10.0g) and 10ml hydrochloric acid.The adjusting hydrogen pressure is 0.8MP, is warming up to 50 ℃, stirs hydrogenation 8 hours.Inhale hydrogen and stop the afterreaction end.Filtered and recycled Pd (OH)
2Catalyzer adds water 200ml, and to transfer pH value with the 1N sodium hydroxide solution be alkalescence, and the pressure reducing and steaming organic solvent has solid to separate out.Washing also gets compound (9) N-Methyl-1H-indole quinoline-5-ethene sulphonamide 15.3g, productive rate 63.2% with ethyl alcohol recrystallization.
The nuclear magnetic data of compound (9) N-Methyl-1H-indole quinoline-5-ethene sulphonamide is as follows:
1H-NMR (CDCl
3) 300MHz, δ (ppm): 2.64 (d, 3H, J=5.4Hz), 3.04 (t, 2H, J=8.4Hz), 3.62 (t, 2H, J=8.4Hz), 3.72 (m, 1H), 4.0 (m, 1H), 6.64 (d, 1H, J=14.4), 7.30～7.55 (m, 3H), 7.62 (d, 1H, J=15.2).
6.N-methyl isophthalic acid-benzyl-indoline-5-ethyl sulfonamide (10) is synthetic
In the hydrogenation still, drop into compound (8) (50.0g, 0.15mol) and tetrahydrofuran (THF) 1200ml, the weight percent that adds Pd is 10% Pd/C catalyzer (5.0g), the adjusting hydrogen pressure is 0.5MP, stirring at room hydrogenation 8 hours.Inhale hydrogen and stop the afterreaction end.Filtered and recycled Pd/C catalyzer.Pressure reducing and steaming organic solvent, ethyl alcohol recrystallization get compound (10) N-methyl isophthalic acid-benzyl-indoline-5-ethyl sulfonamide 43.2g, productive rate 87.3%.
The nuclear magnetic data of compound (10) N-methyl isophthalic acid-benzyl-indoline-5-ethyl sulfonamide is as follows:
1H-NMR (CDCl
3) 300MHz, δ (ppm): 2.61 (d, 3H, J=5.3Hz), 3.03 (t, 2H, J=8.4Hz), 3.62 (t, 2H, J=8.4Hz), 3.19～3.24 (m, 2H), 3.33～3.38 (m, 2H), 3.75 (m, 1H), 4.29 (s, 2H), 7.34～7.48 (m, 3H), 7.50～7.62 (m, 3H).
7.N-Methyl-1H-indole quinoline-5-ethyl sulfonamide (11) is synthetic
(40.0g, 0.12mol) with tetrahydrofuran (THF) 600ml, the weight percent that adds Pd is 10% Pd (OH) to drop into compound (10) in the hydrogenation still
2/ C catalyzer (5.0g).The adjusting hydrogen pressure is 0.5MP, is warming up to 30 ℃, stirs hydrogenation 8 hours.Inhale hydrogen and stop the afterreaction end.Filtered and recycled Pd (OH)
2Catalyzer, the pressure reducing and steaming organic solvent has solid to separate out.Ethyl alcohol recrystallization compound (11) N-Methyl-1H-indole quinoline-5-ethyl sulfonamide 23.3g, productive rate 80.0%.The nuclear magnetic data of N-Methyl-1H-indole quinoline-5-ethyl sulfonamide (11) is as follows:
1H-NMR (CDCl
3) 300MHz, δ (ppm): 2.64 (d, 3H, J=5.4Hz), 3.05 (t, 2H, J=8.4Hz), 3.65 (t, 2H, J=8.4Hz), 3.72 (m, 1H), 3.19～3.24 (m, 2H), 3.33～38 (m, 2H), 4.2 (m, 1H), 6.51 (s, 1H), 7.37 (d, 1H), 7.51 (s, 1H).
8.N-Methyl-1H-indole-5-ethyl sulfonamide (2) is synthetic
(6.0g 0.025mol) and methylene dichloride (300ml) stirring and dissolving, is warming up to 35 ℃ to drop into compound (11) in the four-hole bottle of 500ml.Add Manganse Dioxide (15.0g), room temperature reaction 4 hours, TLC show that reaction finishes.Suction filtration, filter cake 100ml washed with dichloromethane.Merging filtrate steams methylene dichloride, and solid obtains compound (2) N-Methyl-1H-indole-5-ethyl sulfonamide 4.5g, productive rate 75.6% with the methylene dichloride recrystallization.
The nuclear magnetic data of compound (2) N-Methyl-1H-indole-5-ethyl sulfonamide is as follows:
1H-NMR (CDCl
3) 300MHz, δ (ppm): 2.64 (d, 3H, J=5.4Hz), 3.19～3.22 (m, 2H), 3.33～3.38 (m, 2H), 3.75 (d, 1H, J=5.1Hz), 6.52 (s, 1H), 7.06 (d, 1H, J=8.4), 7.22～7.24 (m, 1H), 7.37 (d, 1H, J=8.4Hz), 7.51 (s, 1H), 8.19 (s, 1H).
Embodiment 2
Except that the synthesis condition that changes compound (11), other steps are identical with embodiment 1.
1.N-Methyl-1H-indole quinoline-5-ethyl sulfonamide (11) is synthetic
In the hydrogenation still, drop into compound (9) N-Methyl-1H-indole quinoline-5-ethene sulphonamide (10.0g, 0.042mol) and ethanol 300ml, the weight percent that adds Pd is 10% Pd/C catalyzer (5.0g), and the adjusting hydrogen pressure is 0.5MP, stirring at room hydrogenation 10 hours.Inhale hydrogen and stop the afterreaction end.Filtered and recycled Pd/C catalyzer.Organic solvent in the pressure reducing and steaming filtrate, recrystallization get compound (11) N-Methyl-1H-indole quinoline-5-ethyl sulfonamide 8.2g, productive rate 81.3%.
2.N-Methyl-1H-indole quinoline-5-ethyl sulfonamide (11) is synthetic
(38.2g, 0.10mol) and THF 500ml, the weight percent that adds Pd is that the weight percent of 10% Pd/C catalyzer (5.0g) and Pd is 10% Pd (OH) to drop into compound (8) N-methyl isophthalic acid-benzyl-indoline-5-ethene sulphonamide in the hydrogenation still
2/ C catalyzer (10.0g) and 10ml hydrochloric acid, the adjusting hydrogen pressure is 0.5MP, stirring at room hydrogenation 15 hours.Inhale hydrogen and stop the afterreaction end.Filtered and recycled Pd/C and Pd (OH)
2/ C catalyzer.Add water 300ml, and to transfer pH value with the 1N sodium hydroxide solution be alkalescence, pressure reducing and steaming THF.Use ethyl acetate extraction, the washing and dry ethyl acetate, boil off solvent after recrystallization get compound (1) N-Methyl-1H-indole quinoline-5-ethyl sulfonamide 12.2g, productive rate 50.8%.
Claims (12)
1. the method for synthetic N-Methyl-1H-indole-5-ethyl sulfonamide (2); it is characterized in that with indoline (4) be starting raw material; through radical protection, formylation, obtain target compound N-Methyl-1H-indole-5-ethyl sulfonamide (2) with the condensation of N-methyl Toluidrin, hydrogenating reduction, deprotection base and oxidation step, synthetic route is seen reaction formula 1:
2. method according to claim 1; it is characterized in that described radical protection is a benzyl protection; benzyl chlorine or benzyl bromine are used in the benzyl protection reaction; with N; dinethylformamide is a solvent; in the presence of salt of wormwood, obtained compound (5) in 2～4 hours with indoles woods (4) 60～120 ℃ of reactions, wherein the mol ratio of indoline and benzyl chlorine or benzyl bromine and salt of wormwood is 1: 1.0～1.5: 1.0～1.5.
3. method according to claim 1; it is characterized in that described formylation reaction is the Vilsmeier-Haack formylation reaction: with N; dinethylformamide is a solvent; dripping phosphorus oxychloride formation Vilsmeier reagent below-10～5 ℃; be warming up to again 60～120 ℃ and compound (5) reaction 3～10 hours compound (6), wherein compound (5) is 1: 1～3 with the mol ratio of phosphorus oxychloride.
4. method according to claim 1, the condition that it is characterized in that described condensation reaction is: be solvent with the anhydrous tetrahydro furan, in the presence of sodium tert-butoxide or potassium tert.-butoxide, compound (6) and compound (7)-78 ℃ to system reflux temperature insulation reaction 5-10 hour, wherein compound (6) is 1: 1～4: 1～1.5 with the mol ratio of sodium tert-butoxide or potassium tert.-butoxide and compound (7).
5. according to claim 1 or 4 described methods; it is characterized in that; compound (7) is to use the tert.-butoxy formic anhydride that nitrogen-atoms in the N-methyl Toluidrin is carried out radical protection and obtains; reaction conditions is that N-methyl Toluidrin is in methylene chloride; with the 4-Dimethylamino pyridine is catalyzer; obtained compound (7) in 4～6 hours with the reaction of tert.-butoxy formic anhydride under 5～40 ℃ of temperature, wherein the mol ratio of N-methyl Toluidrin and 4-Dimethylamino pyridine and tert.-butoxy formic anhydride is 1: 0.01～0.05: 1.0～1.5.
6. method according to claim 1 is characterized in that synthetic can earlier reduce the again deprotection base of compound (8) to compound (11), also can restore by first deprotection base, or will reduce and deprotection reaction one goes on foot and carries out with " one kettle way "
7. according to claim 1 or 6 described methods, it is characterized in that described compound (10) and compound (11) reduction reaction in synthetic adopts the method for Pd/C shortening, reaction conditions is: catalyzer is that the weight percent content of Pd is 5～20% Pd/C, catalyst levels is 10～30% of a hydrogenation substrate weight, solvent is methyl alcohol, ethanol, ethyl acetate or tetrahydrofuran (THF), hydrogen pressure is between 0.1～2.0MPa, temperature of reaction is that temperature of reaction is 20～80 ℃, and the reaction times is 3-12 hour.
8. according to claim 1 or 6 described methods, it is characterized in that described compound (9) and compound (11) deprotection reaction in synthetic adopts Pd/C catalytic hydrogenolysis or Pd (OH)
2The method of/C catalytic hydrogenolysis.
9. method according to claim 8 is characterized in that described deprotection reaction adopts Pd (OH)
2The method of/C catalytic hydrogenolysis, Pd (OH)
2The condition of/C catalytic hydrogenolysis is: catalyzer is that the weight percent content of Pd is 5～20% Pd/C, catalyst levels is 10～30% of a hydrogenation substrate weight, solvent is methyl alcohol, ethanol, ethyl acetate or tetrahydrofuran (THF), hydrogen pressure is between 0.1～2.0MPa, temperature of reaction is that temperature of reaction is 20～80 ℃, and the reaction times is 3-12 hour.
10. method according to claim 1, it is characterized in that described oxidizing reaction is a solvent with ethylene dichloride, ethyl acetate, methyl alcohol or ethanol, compound (11) is oxygenant with Manganse Dioxide, obtained compound (2) in 5-10 hour at 5～50 ℃ of temperature range internal reactions, wherein compound (11) is 1: 1～10 with the mol ratio of Manganse Dioxide.
11. be used for the new compound of synthetic N-Methyl-1H-indole-5-ethyl sulfonamide, this compound has following general formula:
Substituent R wherein
1For hydrogen atom, allyl group, benzyl or to methoxy-benzyl, substituent R
2Be N-methyl ethylene sulfoamido or N-methylethyl sulfoamido.
12. compound according to claim 11 is characterized in that described compound is:
N-methyl isophthalic acid-benzyl-indoline-5-ethene sulphonamide, N-Methyl-1H-indole quinoline-5-ethene sulphonamide,
N-Methyl-1H-indole quinoline-5-ethyl sulfonamide or N-methyl isophthalic acid-benzyl-indoline-5-ethyl sulfonamide.
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| CN2010101332398A CN101792411B (en) | 2010-03-26 | 2010-03-26 | New method for combining ethyl sulfonamide |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108707118A (en) * | 2018-06-22 | 2018-10-26 | 江苏阿尔法药业有限公司 | A kind of preparation method of demethyl rosuvastain calcium |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61118362A (en) * | 1984-11-12 | 1986-06-05 | Res Assoc Util Of Light Oil | Production of indole compound |
| CN1332166A (en) * | 1993-09-29 | 2002-01-23 | 葛兰素集团有限公司 | Process for prep. of N-methyl-3-(1-methyl-4-piperidyl)-1H-indole-5-ethyl-sulfonamide |
| CN1789262A (en) * | 2004-12-16 | 2006-06-21 | 上海美通生物科技有限公司 | Improvement of preparation of Naratriptan |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61118362A (en) * | 1984-11-12 | 1986-06-05 | Res Assoc Util Of Light Oil | Production of indole compound |
| CN1332166A (en) * | 1993-09-29 | 2002-01-23 | 葛兰素集团有限公司 | Process for prep. of N-methyl-3-(1-methyl-4-piperidyl)-1H-indole-5-ethyl-sulfonamide |
| CN1789262A (en) * | 2004-12-16 | 2006-06-21 | 上海美通生物科技有限公司 | Improvement of preparation of Naratriptan |
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| Title |
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| 《Tetrahedron》 20011231 Joan Bosch et al Synthesis of 5-(sulfamoylmethyl)indoles 第57卷, 2 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108707118A (en) * | 2018-06-22 | 2018-10-26 | 江苏阿尔法药业有限公司 | A kind of preparation method of demethyl rosuvastain calcium |
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| CN101792411B (en) | 2012-05-30 |
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