CN101780132B - Mongolian medicine for treating osteoporosis and preparation method thereof - Google Patents
Mongolian medicine for treating osteoporosis and preparation method thereof Download PDFInfo
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- CN101780132B CN101780132B CN2009100054706A CN200910005470A CN101780132B CN 101780132 B CN101780132 B CN 101780132B CN 2009100054706 A CN2009100054706 A CN 2009100054706A CN 200910005470 A CN200910005470 A CN 200910005470A CN 101780132 B CN101780132 B CN 101780132B
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Abstract
The invention discloses Mongolian medicine for treating osteoporosis and a preparation method thereof. The Mongolian medicine comprises the following raw medicine: echinops laizfolius and epimedium with the weight ratio thereof being 1:0.5-4. The preparation method comprises the following steps: (1) firstly, extracting echinops laizfolius; (2) extracting epimedium; (3) mixing the echinops laizfolius extract and the epimedium extract pro rata to prepare the Mongolian medicine capsule. The invention has the following advantages that: the Mongolian medicine for treating primary osteoporosis achieves the effects of fixing the bone substance, strengthening bones and muscles and preventing and treating osteoporosis through long-term administration, has low toxicity and side effect and takes the treatment of both symptoms and root causes into consideration; and the process for preparing the Mongolian medicine capsule for treating primary osteoporosis is advanced, stable and feasible, and the effects of raw medicine can be fully achieved by extracting the effective components of the raw medicine.
Description
Technical field:
The present invention relates to a kind of mongolian medicine and preparation method thereof, especially relate to a kind of mongolian medicine of treating primary osteoporosis and preparation method thereof.
Background technology:
Osteoporosis (Osteoporosis OP) is a kind of common metabolic osteopathy, and it reduces with the bone amount and osseous tissue micro structure destruction is principal character, finally causes skeleton fragility to increase easy the fracture.Osteoporosis mainly occurs in old people and menopausal women, and sickness rate high (menopausal women is about 25%-50%) has brought bigger financial burden for individual and society.China's osteoporosis number of patients in 1999 is 8,400 ten thousand according to estimates.Along with the aging of population, the patient will increase year by year, expect 2010 and can reach 1.2 hundred million people, will become serious society and economic problems.The influence of additive factors such as calcium content is low in less, the meals of Aisan's build in addition makes osteoporotic sickness rate apparently higher than other areas, and its effective control just seems particularly important.
The reason of osteoporosis morbidity, outside the Pass having with age and bone degeneration, most researchs think that it is the key of morbidity that change, nutriture (the especially absorption of calcium and the proteinaceous nutrient) physical exertion of hormonal readiness reduce.But at different crowds or individuality, the proportion of these risk factors role in the osteoporosis pathogenic process is different.The herdsman of the Mongols is owing to its living habit and the mode of production, and the incidence rate of bone injury, osteopathia is higher than peasant and urbanite far away, and therefore, bone injury is the advantage subjects in Mongolian medicine's medicine.The inventor is to this difficult and complicated illness of osteoporosis; According to touch upon clinical application experience and combine modern pharmacodynamics of Mongolian medicine's pharmacology; From Mongolian medicine's orthopedics department medicine commonly used, seek the osteoporotic active drug of control; Screen the back prescription, fully excavate the national medicine resource, prevention and treatment of osteoporosis is had great importance.
Summary of the invention:
The mongolian medicine that the object of the present invention is to provide that a kind of toxic and side effects is little, treating both the principal and secondary aspects of a disease and the effective natural drug that can take for a long time prevents and treat primary osteoporosis.
The object of the invention is implemented by following technical scheme: a kind of mongolian medicine of treating primary osteoporosis, its crude drug by following weight ratio is formed: Echinops latifolius: Herba Epimedii is 1: 0.5～4.
A kind of mongolian medicine of treating osteoporosis, said mongolian medicine medicament is a powder, or honey pill agent, or capsule, or tablet, or decoction or watered pill.
A kind of capsular method for preparing of mongolian medicine of treating primary osteoporosis includes following steps: (1), the at first extraction of Echinops latifolius, the extraction of (2), Herba Epimedii, (3), with Echinops latifolius extract and Herba Epimedii extract after 1: 0.5～4 mixed; Wherein the weight of Echinops latifolius extract is in apiin, and the weight of Herba Epimedii extract is crossed the 80-100 mesh sieve in icariin, adds dextrin; Weight ratio after the extract of wherein said dextrin and said Echinops latifolius and the extract of Herba Epimedii mix is 1: 2-4, and mixing is crossed the 80-100 mesh sieve repeatedly, makes the mixture mix homogeneously; The adding mass percent is 95% ethanol, makes moistening the getting final product of mixture of above-mentioned mix homogeneously, and ethanol is made wetting agent and used; Mixture is processed soft material, granulates mixing with the 30-60 mesh sieve; Drying incapsulates, and promptly gets.
The wherein extraction of the said Echinops latifolius of step (1): it includes following steps: the Echinops latifolius of at first getting weight portion and be 40 parts-50 parts is pulverized, use weight be the Echinops latifolius after pulverizing 8-12 doubly, mass percent is that 50～65% ethanol is heated to the fluidized state reflux, extract,, is extracted into to detect through liquid phase process not contain apiin; Or through the ultraviolet method detect do not contain flavone after, merge extractive liquid,, reclaiming ethanol and being concentrated into relative density is 0.90～1.10, temperature is the extractum of room temperature; Add ethanol alcohol and be sink to the alcohol amount 70～85% that contains, filtration is reclaimed ethanol and also is concentrated into the extractum that does not have the alcohol flavor; The thin up unguentum, to the weight of said unguentum for feeding intake 10 times of medical materials, be added on the macroporous adsorptive resins of having handled well; Water and alcohol property solvent successively, eluting is collected alcohol property solvent; Eluent reclaims alcohol property solvent, is concentrated into thick paste; Vacuum drying is pulverized, and promptly gets.
After granulating with the 30-60 mesh sieve, add micropowder silica gel, increase the flowability of said granulation.
The invention has the advantages that: the mongolian medicine of treatment primary osteoporosis has solid sclerotin, bone and muscle strengthening, and toxic and side effects is little, treating both the principal and secondary aspects of a disease also can be taken for a long time, is used for preventing and treating osteoporotic effect.Capsular preparation technology of mongolian medicine of this treatment primary osteoporosis is advanced, and is stable, feasible, and the extraction through to the active ingredient of former medicine makes the drug effect of former medicine be able to fill a part performance.
Description of drawings:
Fig. 1 is a process chart of the present invention.
Embodiment 1: a kind of mongolian medicine of treating primary osteoporosis, be made up of following materials of weight proportions medicine: Echinops latifolius is 100 grams, and Herba Epimedii is 50 grams, pulverizes, and is prepared into powder, takes the 6-9 gram every day twice, one time.
Embodiment 2: a kind of mongolian medicine of treating primary osteoporosis, and be made up of following materials of weight proportions medicine: Echinops latifolius is 100 grams, and Herba Epimedii is 400 grams, pulverizes, and is prepared into honey pill agent, every ball 9 grams are taken twice, one time 9 gram every day.
Embodiment 3: a kind of mongolian medicine of treating primary osteoporosis, be made up of following materials of weight proportions medicine: Echinops latifolius is 100 grams, and Herba Epimedii is 250 grams, pulverizes, and is prepared into watered pill, takes the 6-9 gram every day twice, one time.
Embodiment 4: a kind of mongolian medicine of treating primary osteoporosis, be made up of following materials of weight proportions medicine: Echinops latifolius is 100 grams, and Herba Epimedii is 100 grams, incapsulates after the pulverizing, is prepared into capsule, takes the 6-9 gram every day twice, one time.
Embodiment 5: a kind of mongolian medicine of treating primary osteoporosis, be made up of following materials of weight proportions medicine: Echinops latifolius is 100 grams, and Herba Epimedii is 350 grams, is prepared into tablet, takes the 6-9 gram every day twice, one time.
Embodiment 6: a kind of mongolian medicine mongolian medicine capsule of treating primary osteoporosis, and get following materials of weight proportions medicine: Echinops latifolius is 4000 grams, Herba Epimedii is 4000 grams;
(1), the at first extraction of Echinops latifolius, it includes following steps: the Echinops latifolius of at first getting weight portion and be 4000 grams is pulverized, using weight is 8 times of Echinops latifolius after pulverizing, mass percent is that 50% ethanol is heated to the fluidized state reflux, extract; Be extracted into to detect and do not contain apiin through liquid phase process, or through the ultraviolet method detect do not contain flavone after, merge extractive liquid,, reclaiming ethanol and being concentrated into relative density is 0.90～1.10; Temperature is the extractum of room temperature, adds ethanol alcohol and is sink to the alcohol amount 70～85% that contains, and filtration is reclaimed ethanol and also is concentrated into the extractum that does not have the alcohol flavor; The thin up unguentum, to the weight of unguentum for feeding intake 10 times of medical materials, be added on the macroporous adsorptive resins of having handled well; Water and alcohol property solvent successively, eluting is collected alcohol property solvent; Eluent reclaims alcohol property solvent, is concentrated into thick paste; Vacuum drying is pulverized, and promptly gets the extract of Echinops latifolius.
(2), the extraction of Herba Epimedii, get crude drug Herba Epimedii 4000 grams, press the common process extraction;
(3), with Echinops latifolius extract (in apiin) and Herba Epimedii extract (in icariin), Echinops latifolius extract 100 gram after Herba Epimedii extract 50 grams mix, is crossed the 80-100 mesh sieve; Add dextrin 75 grams, mixing is crossed the 80-100 mesh sieve repeatedly, makes the mixture mix homogeneously; The adding mass percent is 95% ethanol, makes moistening the getting final product of mixture of above-mentioned mix homogeneously, and ethanol is made wetting agent usefulness, and mixture is processed soft material; Granulate with the 30-60 mesh sieve, add an amount of micropowder silica gel, make the flowability of granulating strengthen, again mixing; Drying incapsulates, and promptly gets.
Embodiment 7: a kind of mongolian medicine capsule of treating primary osteoporosis, and get following materials of weight proportions medicine: Echinops latifolius is 4000 grams, Herba Epimedii is 4000 grams;
(1), the at first extraction of Echinops latifolius, it includes following steps: the Echinops latifolius of at first getting weight portion and be 4000 grams is pulverized, using weight is 12 times of Echinops latifolius after pulverizing, mass percent is that 60% ethanol is heated to the fluidized state reflux, extract; Be extracted into to detect and do not contain apiin through liquid phase process, or through the ultraviolet method detect do not contain flavone after, merge extractive liquid,, reclaiming ethanol and being concentrated into relative density is 0.90～1.10; Temperature is the extractum of room temperature, adds ethanol alcohol and is sink to the alcohol amount 70～85% that contains, and filtration is reclaimed ethanol and also is concentrated into the extractum that does not have the alcohol flavor; The thin up unguentum, to the weight of unguentum for feeding intake 10 times of medical materials, be added on the macroporous adsorptive resins of having handled well; Water and alcohol property solvent successively, eluting is collected alcohol property solvent; Eluent reclaims alcohol property solvent, is concentrated into thick paste; Vacuum drying is pulverized, and promptly gets the extract of Echinops latifolius.
(2), the extraction of Herba Epimedii, get crude drug Herba Epimedii 4000 grams, press the common process extraction;
(3), with Echinops latifolius extract (in apiin) and Herba Epimedii extract (in icariin), Echinops latifolius extract 100 gram after Herba Epimedii extract 400 grams mix, is crossed the 80-100 mesh sieve; Add dextrin 125 grams, mixing is crossed the 80-100 mesh sieve repeatedly, makes the mixture mix homogeneously; The adding mass percent is 95% ethanol, makes moistening the getting final product of mixture of above-mentioned mix homogeneously, and ethanol is made wetting agent usefulness, and mixture is processed soft material; Granulate with the 30-60 mesh sieve, add an amount of micropowder silica gel, make the flowability of granulating strengthen, again mixing; Drying incapsulates, and promptly gets.
Embodiment 8: a kind of mongolian medicine mongolian medicine capsule of treating primary osteoporosis, and get following materials of weight proportions medicine: Echinops latifolius is 4000 grams, Herba Epimedii is 4000 grams;
(1), the at first extraction of Echinops latifolius, it includes following steps: the Echinops latifolius of at first getting weight portion and be 4000 grams is pulverized, using weight is 10 times of Echinops latifolius after pulverizing, mass percent is that 58% ethanol is heated to the fluidized state reflux, extract; Be extracted into to detect and do not contain apiin through liquid phase process, or through the ultraviolet method detect do not contain flavone after, merge extractive liquid,, reclaiming ethanol and being concentrated into relative density is 0.90～1.10; Temperature is the extractum of room temperature, adds ethanol alcohol and is sink to the alcohol amount 70～85% that contains, and filtration is reclaimed ethanol and also is concentrated into the extractum that does not have the alcohol flavor; The thin up unguentum, to the weight of unguentum for feeding intake 10 times of medical materials, be added on the macroporous adsorptive resins of having handled well; Water and alcohol property solvent successively, eluting is collected alcohol property solvent; Eluent reclaims alcohol property solvent, is concentrated into thick paste; Vacuum drying is pulverized, and promptly gets the extract of Echinops latifolius.
(2), the extraction of Herba Epimedii, get crude drug Herba Epimedii 4000 grams, press the common process extraction;
(3), with Echinops latifolius extract (in apiin) and Herba Epimedii extract (in icariin), Echinops latifolius extract 100 gram after Herba Epimedii extract 250 grams mix, is crossed the 80-100 mesh sieve; Add dextrin 100 grams, mixing is crossed the 80-100 mesh sieve repeatedly, makes the mixture mix homogeneously; The adding mass percent is 95% ethanol, makes moistening the getting final product of mixture of above-mentioned mix homogeneously, and ethanol is made wetting agent usefulness, and mixture is processed soft material; Granulate with the 30-60 mesh sieve, add an amount of micropowder silica gel, make the flowability of granulating strengthen, again mixing; Drying incapsulates, and promptly gets.
Embodiment 9: according to the mongolian medicine of the treatment primary osteoporosis of embodiment 1-8 gained, for following case:
Clinical data
Physical data: selecting has lumbar and back pain, vertebral body that tenderness, percussion pain or existing vertebral compression fracture are arranged before and after the menopause, is diagnosed as osteoporosis women 25 examples through inspection of X line plain film and dual intensity X line borne densitometers mensuration.Adopt double blinding, randomized to be divided into 2 groups, test group 15 examples, matched group 10 examples.
The Therapeutic Method test group is taken the mongolian medicine of the treatment primary osteoporosis of embodiment 1-7 gained; Oral 1 time/day of matched group Gaierqi D (vitamin D3 and calcium carbonate) 1200mg, curative effect was judged in treatment in 3-6 month.
Observation item
The ultra distal bone density of dual intensity X line borne densitometers inspection radius is respectively surveyed 1 time before and after taking medicine.Respectively survey 1 time before and after the biochemical ALP medication of blood.
Curative effect judging standard
Produce effects: the breast lumbar and back pain obviously alleviates or disappears basically, and functional activity is normal;
Effectively: the breast lumbar and back pain alleviates, and functional activity is normal basically;
Invalid: the breast lumbar and back pain does not see and alleviates that functional activity is not seen improvement.
2 results
Show according to above statistical result: all obviously improve before the treatment matched group, experimental group distal radius bone density treatment back, P＜0.05, and matched group, experimental group treatment back distal radius bone density be no significant difference P＞0.05 relatively.The more preceding obvious reduction P of ALP＜0.05 before treating behind matched group, the experimental group serum treatment, matched group, experimental group treatment back serum levels of ALP be no significant difference P＞0.05 relatively.But with regard to improving clinical symptoms, experimental group obviously is superior to matched group.
Claims (2)
1. a mongolian medicine of treating primary osteoporosis is characterized in that, its crude drug by following weight ratio is formed: Echinops latifolius: Herba Epimedii is 1: 0.5～4.
2. a kind of mongolian medicine of treating osteoporosis as claimed in claim 1 is characterized in that said mongolian medicine medicament is a powder.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2009100054706A CN101780132B (en) | 2009-01-17 | 2009-01-17 | Mongolian medicine for treating osteoporosis and preparation method thereof |
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| CN2009100054706A CN101780132B (en) | 2009-01-17 | 2009-01-17 | Mongolian medicine for treating osteoporosis and preparation method thereof |
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| CN101780132B true CN101780132B (en) | 2012-03-07 |
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| CN105726979A (en) * | 2016-04-19 | 2016-07-06 | 元和药业股份有限公司 | New application of Mongolian medicine compound preparation conic-gymnadenia-tuber, radix-polygonati-officinalis and rhizome-polygonati medicine and medicinal preparation and preparing method of Mongolian medicine compound preparation |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1416873A (en) * | 2002-11-21 | 2003-05-14 | 烟台荣昌制药有限公司 | A pharmaceutical composition for treating osteoporosis, and its preparation method |
| CN1660196A (en) * | 2004-12-13 | 2005-08-31 | 武汉健民中药工程有限责任公司 | Extractive of Chinese traditional medicine prepared from epimedium and drynaria, and method for producing preparation |
| CN1907315A (en) * | 2005-08-02 | 2007-02-07 | 孙毅 | Orthopaedics disease treating and preventing medicinal composition |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1416873A (en) * | 2002-11-21 | 2003-05-14 | 烟台荣昌制药有限公司 | A pharmaceutical composition for treating osteoporosis, and its preparation method |
| CN1660196A (en) * | 2004-12-13 | 2005-08-31 | 武汉健民中药工程有限责任公司 | Extractive of Chinese traditional medicine prepared from epimedium and drynaria, and method for producing preparation |
| CN1907315A (en) * | 2005-08-02 | 2007-02-07 | 孙毅 | Orthopaedics disease treating and preventing medicinal composition |
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Address after: 010010 Propaganda Department of the Inner Mongolia Autonomous Region Party committee Applicant after: Bi Lifu Co-applicant after: Chang Hong Address before: 010050 Department of traditional Chinese medicine, Affiliated Hospital of Inner Mongolia Medical College, Hohhot, the Inner Mongolia Autonomous Region Applicant before: Chang Hong Co-applicant before: Bi Lifu |
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