CN101780100A - Water-soluble vitamin composition for injection and preparation method thereof - Google Patents
Water-soluble vitamin composition for injection and preparation method thereof Download PDFInfo
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- CN101780100A CN101780100A CN 201010108024 CN201010108024A CN101780100A CN 101780100 A CN101780100 A CN 101780100A CN 201010108024 CN201010108024 CN 201010108024 CN 201010108024 A CN201010108024 A CN 201010108024A CN 101780100 A CN101780100 A CN 101780100A
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Abstract
The invention relates to a water-soluble vitamin composition for injection and a preparation method thereof, which belongs to the technical field of drug preparation. Based on research of the vitamin products for injection in the market and through a plurality of formula research, the invention solves the problem of compatibility stability between nitrate thiamine, riboflavin sodium phosphate, nicotinamide, glycine and vitamin B1, vitamin B2 and vitamin B6, provides a new formula of the water-soluble vitamin composition for injection, and preparation technologies such as thermal dissolution, protection by charging inert gas, ultrasonic dispersion under normal temperature are used to prepare stable water-soluble vitamin composition for injection. The formula of the water-soluble vitamin composition for injection provided by the invention comprises vitamin B1, vitamin B2, vitamin B6, vitamin C, thiamine nitrate, biotin, riboflavin sodium phosphate, folic acid, nicotinamide, vitamin B12, glycine, pan-sodium, methyl-p-hydroxybenzoate, vitamin C sodium and disodium ethylene diamine tetraacetate.
Description
Technical field:
The present invention relates to a kind of water-soluble vitamin composition for injection and preparation method thereof, relate to a kind of pharmaceutical preparation that is used for subvitaminosis disease and preparation method thereof, belong to field of medicine preparing technology.
Background technology:
For a long time, the ratio that the disease that causes because of vitamin deficiency or vitamin deficiency accounts for clinical disease is very high always, and the reasonable supplement vitamin more and more causes people's extensive attention.Cause the avitaminous reason of needed by human body to have a lot, as the food scarcity, it is improper that food transports, stores, processes, and causes the vitamin in the food to lose, and the result causes the vitamin Deficiency of Intake; When people's digestive and absorptive functions reduces, as chew that deficiency, gastrointestinal function reduce, hypoliposis in the meals, cellulose are too much etc. can cause the vitamin digestibility to descend; The crowd of different physiology phases, as the women of pregnant lactication phase, the child of growth and development stage, the crowd of disease, average of operation periods increases relatively to the requirement of vitamin; The crowd of down life of special environment, work because the cause of stress or environmental pollution, increases relatively to the requirement of vitamin.Water soluble vitamins is the indispensable micronutrient of human body, to health and to keep the normal function of body extremely important, is one of indispensable ingredient of parenteral nutrition, in order to satisfy adult and the child every day physiological need to water soluble vitamins.Need an amount of absorption or additional every day,, each relevant biochemical reaction of body can normally be carried out in order to replenish the physiological need of various water soluble vitamins every day.Water soluble vitamin participates in the composition of enzyme system in vivo, and most vitamin participate in intravital metabolic process as the constituent of coenzyme or prothetic group.The disclosed prescription of Vitamin H product of listing mainly contains following several at present: the prescription of (1) every water for injection soluble vitamin consists of thiamine mononitrate, riboflavin sodium phosphate, nicotiamide, pyridoxine hydrochloride, sodium pantothenate, vitamin C, biotin, folic acid, vitamin B
12(2) prescription of every water for injection soluble vitamin consists of glycine, cysteine hydrochloride, disodium edetate, methyl parahydroxybenzoate, sodium ascorbate, folic acid, thiamine mononitrate, riboflavin sodium phosphate, vitamin B
6, biotin, vitamin B
12, sodium pantothenate, nicotiamide.(3) prescription of every water for injection soluble vitamin consists of thiamine mononitrate, nicotiamide, pyridoxine hydrochloride, sodium pantothenate, riboflavin sodium phosphate, sodium ascorbate, biotin, folic acid, vitamin B
12And methyl parahydroxybenzoate.(4) prescription of every water for injection soluble vitamin consists of vitamin B
1, biotin, vitamin B
2, folic acid, nicotiamide, vitamin B
12, vitamin B
6, glycine, sodium pantothenate, methyl parahydroxybenzoate, vitamin C, disodiumedetate, every water for injection soluble vitamin of sodium ethylene diamine tetracetate calcium (5) prescription consist of vitamin B
1, biotin, vitamin B
2, folic acid, nicotiamide, vitamin B
12, vitamin B
6, sodium pantothenate, methyl parahydroxybenzoate, vitamin C, disodiumedetate.(6) prescription of every water for injection soluble vitamin consists of vitamin B
1, biotin, vitamin B
2, folic acid, nicotiamide, vitamin B
12, vitamin B
6, glycine, sodium pantothenate, vitamin C, disodiumedetate.(7) prescription of every water for injection soluble vitamin consists of thiamine mononitrate, riboflavin sodium phosphate, nicotiamide, pyridoxine hydrochloride, sodium pantothenate, sodium ascorbate, biotin, folic acid, vitamin B
12, glycine, Calcium Disodium Versenate.For many years, thiamine mononitrate, riboflavin sodium phosphate, nicotiamide, glycine etc. and vitamin B
1, vitamin B
2, vitamin B
6, vitamin B
12Deng the compatibility stability problem be the problem that the study of pharmacy personnel pay close attention to always, mainly be to be difficult to said vitamin is prepared into stable uniform dispersion, to so far, still do not have sophisticated research report.The present invention is on listing product research basis; through a large amount of formulatings; physicochemical property according to different vitamin; adopt different dissolving dispersing technologies; in conjunction with Technologies such as heat of solution, room temperature ultra-sonic dispersion technology, inert gas shieldings, successful first solution thiamine mononitrate, riboflavin sodium phosphate, nicotiamide, glycine etc. and vitamin B
1, vitamin B
2, vitamin B
6, vitamin B
12Etc. the compatibility stability problem, with thiamine mononitrate, riboflavin sodium phosphate, nicotiamide, glycine etc. and vitamin B
1, vitamin B
2, vitamin B
6, vitamin B
12Deng being prepared into stable dispersion, a kind of new water for injection soluble vitamin composition and method of making the same is proposed.The water for injection soluble vitamin composite formula that the present invention proposes consists of vitamin B
1, vitamin B
2, vitamin B
6, vitamin C, thiamine mononitrate, biotin, riboflavin sodium phosphate, folic acid, nicotiamide, vitamin B
12, glycine, sodium pantothenate, methyl parahydroxybenzoate, sodium ascorbate, Calcium Disodium Versenate.
Summary of the invention:
The present invention proposes a kind of water for injection soluble vitamin composition and method of making the same, and the said composition prescription is as follows:
Vitamin B
12.6～3.3g vitamin B
222.9～4.1g
Vitamin B
63.5～4.5g vitamin C 90～110g
Thiamine mononitrate 2.5-3.8g biotin 50-70mg
Riboflavin sodium phosphate 4.1-5.7g folic acid 0.3-0.5g
Nicotiamide 35-47g vitamin B
124.5-5.5mg
Glycine 260-345g
Sodium pantothenate 14.5-18.5g methyl parahydroxybenzoate 0.4-0.6g
Sodium ascorbate 100-120g Calcium Disodium Versenate 0.4-0.6g
Water for injection adds to 3000ml and makes 1000
A kind of water for injection soluble vitamin preparation of compositions method that the present invention proposes is as follows:
1. be to add water for injection 0.8-1.2L in the supersound extraction device of 5L, frequency 25khz, power 1kw at capacity, the methyl parahydroxybenzoate and the disodiumedetate that take by weighing formula ratio 1/4-1/2 add in the water for injection, after ultrasonic 5 minutes, powered-down adds the vitamin B of formula ratio successively
1, vitamin B
2, folic acid, nicotiamide, vitamin B
12, vitamin B
6, vitamin C, ultrasonic 10 minutes to dissolving thoroughly, medicinal liquid is through 0.22 μ m filtering with microporous membrane, medicinal liquid I is standby.
2. be in the hermetic container of 5L at capacity, add water for injection 1.8-2.2L, take by weighing the glycine of formula ratio and methyl parahydroxybenzoate and the disodiumedetate of formula ratio 1/2-3/4 and add in the water for injection, heating makes dissolving, simultaneously, feed noble gas.The thiamine mononitrate, biotin, riboflavin sodium phosphate, sodium pantothenate, the sodium ascorbate that add formula ratio again are stirred to the medicinal liquid dissolving thoroughly, and medicinal liquid is transferred to medicinal liquid in another 5L hermetic container through 0.22 μ m filtering with microporous membrane, and it is standby to get medicinal liquid II.
3. medicinal liquid I and medicinal liquid II are merged, continue to feed noble gas, fill under aseptic condition adds the ventilation plug.Put pre-freeze in the freeze dryer, treat temperature reduce to-40 ℃ begin to be incubated 2 hours after, beginning evacuation, and be warming up to-25 ℃ with 2 ℃/hour.Freeze again to-40 ℃, be warming up to 40 ℃ with 5 ℃/hour, keep after 3.5 hours, feed clean nitrogen to 1 atmospheric pressure in freeze dryer, dividing plate is fallen tamponade, semi-finished product enter and roll bottle stopper machine roll tight lid under local 10,000 grades of environment, after sorting out defective work, labeling, dress box, promptly.
The present invention changes conventional freeze-dry process into following steps under the constant situation of writing out a prescription:
Step 1: goods pre-freeze is to-40 ℃, and heating is risen again to-25 ℃.
Step 2: goods-25 ℃ freeze to-40 ℃, heat temperature raising to 40 ℃ insulation 3.5 hours.
Through improvement of the present invention, the water-soluble vitamin composition for injection that obtains stability obviously improves.
Below be stable contrast experiment's research:
Material:
Reference substance: Vitamin H (listing product, the component of per 1000 water for injection soluble vitamins is: thiamine mononitrate 3.1g, riboflavin sodium phosphate 4.9g, nicotiamide 40g, vitamin B6 4.9g, sodium pantothenate 16.5g, sodium ascorbate 113g, biotin 60mg, folic acid 0.4g, vitamin B12 5.0mg, glycine 300g, Calcium Disodium Versenate 0.5g, methyl parahydroxybenzoate 0.5g) is product in contrast
Test specimen: (adopt the water-soluble vitamin composition for injection of the method preparation of embodiment 1, the component of every water for injection soluble vitamin compositions is a vitamin B to the water-soluble vitamin composition for injection that the present invention proposes
12.6g, vitamin B
22.9g, vitamin B
63.5g, vitamin C 90g, thiamine mononitrate 2.5g, biotin 50mg, riboflavin sodium phosphate 4.1g, folic acid 0.3g, nicotiamide 35g, vitamin B
124.5mg, glycine 260g, sodium pantothenate 14.5g, methyl parahydroxybenzoate 0.4g, sodium ascorbate 100g, Calcium Disodium Versenate 0.4g)
Test item: character, acidity value (pH value), clarity, aseptic, bacterial endotoxin, each component content etc., drug standard are selected from standard under two ones of Chinese Pharmacopoeia versions in 2005 and two the 5th continuous items of Ministry of Health of the People's Republic of China's standard.
1. long term test
Sample is placed under 25 ℃ ± 2 ℃ of temperature, appropriate relatively 65% condition, and time sampling respectively at 0,3,6 month, by the desired investigation project of stability test character, acidity value (pH value), clarity, aseptic, bacterial endotoxin, each component content etc. are detected, result of the test show sample of the present invention through 25 ℃ of long-term stable experiments after 6 months the every index of sample all be better than reference substance.
2. accelerated test
Sample placed under 40 ℃ ± 2 ℃, appropriate relatively 75% condition investigate six months, and take a sample during respectively at 0 month, January, February, March and June, by the desired investigation project of stability test character, acidity value (pH value), clarity, aseptic, bacterial endotoxin, each component content etc. are detected, result of the test shows that sample of the present invention was through 40 ℃ of accelerated tests six months, each investigation project changes less, and all each investigation projects all are better than reference substance.
The selected container capacity of a kind of water for injection soluble vitamin preparation of compositions method that the present invention proposes can be selected the container of different size with the variation of medication preparation amount.
The specific embodiment:
Embodiment 1
Prescription (1000):
Vitamin B
12.6g vitamin B
22.9g
Vitamin B
63.5g vitamin C 90g
Thiamine mononitrate 2.5g biotin 50mg
Riboflavin sodium phosphate 4.1g folic acid 0.3g
Nicotiamide 35g vitamin B
124.5mg
Glycine 260g
Sodium pantothenate 14.5g methyl parahydroxybenzoate 0.4g
Sodium ascorbate 100g Calcium Disodium Versenate 0.4g
Water for injection adds to 3000ml and makes 1000
Preparation technology:
1. be to add water for injection 0.8L in the supersound extraction device of 5L, frequency 25khz, power 1kw at capacity, taking by weighing half methyl parahydroxybenzoate and disodiumedetate of formula ratio adds in the water for injection, after ultrasonic 5 minutes, powered-down adds the vitamin B of formula ratio successively
1, vitamin B
2, folic acid, nicotiamide, vitamin B
12, vitamin B
6, vitamin C, ultrasonic 10 minutes to dissolving thoroughly, medicinal liquid is through 0.22 μ m filtering with microporous membrane, medicinal liquid I is standby.
2. be in the hermetic container of 5L at capacity, add water for injection 2.2L, take by weighing half methyl parahydroxybenzoate and disodiumedetate of the glycine of formula ratio and formula ratio and add in the water for injection, heating makes dissolving, simultaneously, feeds noble gas.The thiamine mononitrate, biotin, riboflavin sodium phosphate, sodium pantothenate, the sodium ascorbate that add formula ratio again are stirred to the medicinal liquid dissolving thoroughly, and medicinal liquid is transferred to medicinal liquid in another 5L hermetic container through 0.22 μ m filtering with microporous membrane, and it is standby to get medicinal liquid II.
3. medicinal liquid I and medicinal liquid II are merged, continue to feed noble gas, fill under aseptic condition adds the ventilation plug.Put pre-freeze in the freeze dryer, treat temperature reduce to-40 ℃ begin to be incubated 2 hours after, beginning evacuation, and be warming up to-25 ℃ with 2 ℃/hour.Freeze again to-40 ℃, be warming up to 40 ℃ with 5 ℃/hour, keep after 3.5 hours, feed clean nitrogen to 1 atmospheric pressure in freeze dryer, dividing plate is fallen tamponade, semi-finished product enter and roll bottle stopper machine roll tight lid under local 10,000 grades of environment, after sorting out defective work, labeling, dress box, promptly.
Embodiment two:
Prescription (1000):
Vitamin B
1The 3g vitamin B
23.5g
Vitamin B
64g vitamin C 100mg
Thiamine mononitrate 3.1g biotin 55mg
Riboflavin sodium phosphate 4.9g folic acid 0.35g
Nicotiamide 40g vitamin B
124.9mg
Glycine 300g
Sodium pantothenate 16g methyl parahydroxybenzoate 0.48g
Sodium ascorbate 110g Calcium Disodium Versenate 0.48g
Water for injection adds to 3000ml and makes 1000
A kind of water for injection soluble vitamin preparation of compositions method that the present invention proposes is as follows:
1. be to add water for injection 1L in the supersound extraction device of 5L, frequency 25khz, power 1kw at capacity, the methyl parahydroxybenzoate and the disodiumedetate that take by weighing formula ratio 1/3 add in the water for injection, after ultrasonic 5 minutes, powered-down adds the vitamin B of formula ratio successively
1, vitamin B
2, folic acid, nicotiamide, vitamin B
12, vitamin B
6, vitamin C, ultrasonic 10 minutes to dissolving thoroughly, medicinal liquid is through 0.22 μ m filtering with microporous membrane, medicinal liquid I is standby.
2. be in the hermetic container of 5L at capacity, add water for injection 2L, take by weighing the glycine of formula ratio and the methyl parahydroxybenzoate and the disodiumedetate of formula ratio 2/3 and add in the water for injection, heating makes dissolving, simultaneously, feeds noble gas.The thiamine mononitrate, biotin, riboflavin sodium phosphate, sodium pantothenate, the sodium ascorbate that add formula ratio again are stirred to the medicinal liquid dissolving thoroughly, and medicinal liquid is transferred to medicinal liquid in another 5L hermetic container through 0.22 μ m filtering with microporous membrane, and it is standby to get medicinal liquid II.
3. medicinal liquid I and medicinal liquid II are merged, continue to feed noble gas, fill under aseptic condition adds the ventilation plug.Put pre-freeze in the freeze dryer, treat temperature reduce to-40 ℃ begin to be incubated 2 hours after, beginning evacuation, and be warming up to-25 ℃ with 2 ℃/hour.Freeze again to-40 ℃, be warming up to 40 ℃ with 5 ℃/hour, keep after 3.5 hours, feed clean nitrogen to 1 atmospheric pressure in freeze dryer, dividing plate is fallen tamponade, semi-finished product enter and roll bottle stopper machine roll tight lid under local 10,000 grades of environment, after sorting out defective work, labeling, dress box, promptly.
Embodiment three:
Prescription (1000):
Vitamin B
113.1g vitamin B
24g
Vitamin B
64.2g vitamin C 105mg
Thiamine mononitrate 3.6g biotin 65mg
Riboflavin sodium phosphate 5.2g folic acid 0.45g
Nicotiamide 42g vitamin B
125.1mg
Glycine 315g
Sodium pantothenate 17g methyl parahydroxybenzoate 0.55g
Sodium ascorbate 112g Calcium Disodium Versenate 0.55g
Water for injection adds to 3000ml and makes 1000
A kind of water for injection soluble vitamin preparation of compositions method that the present invention proposes is as follows:
1. be to add water for injection 1.15L in the supersound extraction device of 5L, frequency 25khz, power 1kw at capacity, the methyl parahydroxybenzoate and the disodiumedetate that take by weighing formula ratio 1/2 add in the water for injection, after ultrasonic 5 minutes, powered-down adds the vitamin B of formula ratio successively
1, vitamin B
2, folic acid, nicotiamide, vitamin B
12, vitamin B
6, vitamin C, ultrasonic 10 minutes to dissolving thoroughly, medicinal liquid is through 0.22 μ m filtering with microporous membrane, medicinal liquid I is standby.
2. be in the hermetic container of 5L at capacity, add water for injection 1.85L, take by weighing the glycine of formula ratio and the methyl parahydroxybenzoate and the disodiumedetate of formula ratio 1/2 and add in the water for injection, heating makes dissolving, simultaneously, feeds noble gas.The thiamine mononitrate, biotin, riboflavin sodium phosphate, sodium pantothenate, the sodium ascorbate that add formula ratio again are stirred to the medicinal liquid dissolving thoroughly, and medicinal liquid is transferred to medicinal liquid in another 5L hermetic container through 0.22 μ m filtering with microporous membrane, and it is standby to get medicinal liquid II.
3. medicinal liquid I and medicinal liquid II are merged, continue to feed noble gas, fill under aseptic condition adds the ventilation plug.Put pre-freeze in the freeze dryer, treat temperature reduce to-40 ℃ begin to be incubated 2 hours after, beginning evacuation, and be warming up to-25 ℃ with 2 ℃/hour.Freeze again to-40 ℃, be warming up to 40 ℃ with 5 ℃/hour, keep after 3.5 hours, feed clean nitrogen to 1 atmospheric pressure in freeze dryer, dividing plate is fallen tamponade, semi-finished product enter and roll bottle stopper machine roll tight lid under local 10,000 grades of environment, after sorting out defective work, labeling, dress box, promptly.
Claims (2)
1. water for injection soluble vitamin compositions, the weight of each composition is as follows in the prescription when 1000 water for injection soluble vitamin compositionss of preparation:
Vitamin B
12.6～3.3g vitamin B
22.9～4.1g
Vitamin B
63.5～4.5g vitamin C 90～110g
Thiamine mononitrate 2.5-3.8g biotin 50-70mg
Riboflavin sodium phosphate 4.1-5.7g folic acid 0.3-0.5g
Nicotiamide 35-47g vitamin B
124.5-5.5mg
Glycine 260-345g
Sodium pantothenate 14.5-18.5g methyl parahydroxybenzoate 0.4-0.6g
Sodium ascorbate 100-120g Calcium Disodium Versenate 0.4-0.6g
Water for injection adds to 3000ml and makes 1000
2. water for injection soluble vitamin preparation of compositions method is characterized in that: the weight of each composition is as follows in the prescription when 1000 water for injection soluble vitamin compositionss of preparation:
Vitamin B
12.6～3.3g vitamin B
22.9～4.1g
Vitamin B6 3.5～4.5g vitamin C 90～110g
Thiamine mononitrate 2.5-3.8g biotin 50-70mg
Riboflavin sodium phosphate 4.1-5.7g folic acid 0.3-0.5g
Nicotiamide 35-47g vitamin B
124.5-5.5mg
Glycine 260-345g
Sodium pantothenate 14.5-18.5g methyl parahydroxybenzoate 0.4-0.6g
Sodium ascorbate 100-120g Calcium Disodium Versenate 0.4-0.6g
Water for injection adds to 3000ml and makes 1000
Its preparation process comprises the steps:
(1) be to add water for injection 0.8-1.2L in the supersound extraction device of 5L, frequency 25khz, power 1kw at capacity, the methyl parahydroxybenzoate and the disodiumedetate that take by weighing formula ratio 1/4-1/2 add in the water for injection, after ultrasonic 5 minutes, powered-down adds the vitamin B of formula ratio successively
1, vitamin B
2, folic acid, nicotiamide, vitamin B
12, vitamin B
6, vitamin C, ultrasonic 10 minutes to dissolving thoroughly, medicinal liquid is through 0.22 μ m filtering with microporous membrane, medicinal liquid I is standby.
(2) be in the hermetic container of 5L at capacity, add water for injection 1.8-2.2L, take by weighing the glycine of formula ratio and methyl parahydroxybenzoate and the disodiumedetate of formula ratio 1/2-3/4 and add in the water for injection, heating makes dissolving, simultaneously, feed noble gas.The thiamine mononitrate, biotin, riboflavin sodium phosphate, pyridoxine hydrochloride, sodium pantothenate, the sodium ascorbate that add formula ratio again, be stirred to the medicinal liquid dissolving thoroughly, medicinal liquid is transferred to medicinal liquid in another 5L hermetic container through 0.22 μ m filtering with microporous membrane, and it is standby to get medicinal liquid II.
(3) medicinal liquid I and medicinal liquid II are merged, continue to feed noble gas, fill under aseptic condition adds the ventilation plug.Put pre-freeze in the freeze dryer, treat temperature reduce to-40 ℃ begin to be incubated 2 hours after, beginning evacuation, and be warming up to-25 ℃ with 2 ℃/hour.Freeze again to-40 ℃, be warming up to 40 ℃ with 5 ℃/hour, keep after 3.5 hours, feed clean nitrogen to 1 atmospheric pressure in freeze dryer, dividing plate is fallen tamponade, semi-finished product enter and roll bottle stopper machine roll tight lid under local 10,000 grades of environment, after sorting out defective work, labeling, dress box, promptly.
The selected container capacity of a kind of water for injection soluble vitamin preparation of compositions method that the present invention proposes can be selected the container of different size with the variation of medication preparation amount.
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|---|---|---|---|
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| CN101780100B CN101780100B (en) | 2011-12-21 |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102429919A (en) * | 2011-09-18 | 2012-05-02 | 云南滇峰药业有限公司 | Water-soluble vitamin combination medicine |
| CN102552294A (en) * | 2012-01-10 | 2012-07-11 | 辽宁海思科制药有限公司 | Compound vitamin (3) freeze-dried powder injection for injection and preparation method and analysis method thereof |
| CN103705383A (en) * | 2013-12-18 | 2014-04-09 | 山东新时代药业有限公司 | Oxaliplatin lyophilized powder injection |
| CN104382865A (en) * | 2014-10-29 | 2015-03-04 | 武汉汇海医药有限公司 | Water-soluble vitamin pharmaceutical composition for injection |
| JP2015518377A (en) * | 2012-05-02 | 2015-07-02 | ディーエスエム アイピー アセッツ ビー．ブイ． | Aqueous sterile vitamin formulation |
| CN113197834A (en) * | 2021-04-21 | 2021-08-03 | 河南瑞珀斯生物科技有限公司 | Stem cell exosome freeze-dried powder for beauty treatment and skin care and preparation method thereof |
| CN115054572A (en) * | 2022-05-19 | 2022-09-16 | 西藏邦臣药业集团有限公司 | Vitamin C injection containing biotin and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1640396A (en) * | 2004-01-02 | 2005-07-20 | 广东奇方药业有限公司 | Novel medicinal compositions |
| CN1824309A (en) * | 2005-12-31 | 2006-08-30 | 无锡凯夫制药有限公司 | Method of preparing soluble vitamin for injection using ultra sonic wave oscillation technology and its medicinal preparation |
| CN1939333A (en) * | 2005-09-29 | 2007-04-04 | 重庆药友制药有限责任公司 | Preparation of injecting soluble vitamines |
| CN101422429A (en) * | 2008-11-28 | 2009-05-06 | 陈光荣 | Water-soluble vitamin for injection and preparation method thereof |
-
2010
- 2010-02-10 CN CN2010101080240A patent/CN101780100B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1640396A (en) * | 2004-01-02 | 2005-07-20 | 广东奇方药业有限公司 | Novel medicinal compositions |
| CN1939333A (en) * | 2005-09-29 | 2007-04-04 | 重庆药友制药有限责任公司 | Preparation of injecting soluble vitamines |
| CN1824309A (en) * | 2005-12-31 | 2006-08-30 | 无锡凯夫制药有限公司 | Method of preparing soluble vitamin for injection using ultra sonic wave oscillation technology and its medicinal preparation |
| CN101422429A (en) * | 2008-11-28 | 2009-05-06 | 陈光荣 | Water-soluble vitamin for injection and preparation method thereof |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102429919A (en) * | 2011-09-18 | 2012-05-02 | 云南滇峰药业有限公司 | Water-soluble vitamin combination medicine |
| CN102552294A (en) * | 2012-01-10 | 2012-07-11 | 辽宁海思科制药有限公司 | Compound vitamin (3) freeze-dried powder injection for injection and preparation method and analysis method thereof |
| JP2015518377A (en) * | 2012-05-02 | 2015-07-02 | ディーエスエム アイピー アセッツ ビー．ブイ． | Aqueous sterile vitamin formulation |
| CN103705383A (en) * | 2013-12-18 | 2014-04-09 | 山东新时代药业有限公司 | Oxaliplatin lyophilized powder injection |
| CN104382865A (en) * | 2014-10-29 | 2015-03-04 | 武汉汇海医药有限公司 | Water-soluble vitamin pharmaceutical composition for injection |
| CN104382865B (en) * | 2014-10-29 | 2017-01-11 | 武汉汇海医药有限公司 | Water-soluble vitamin pharmaceutical composition for injection |
| CN113197834A (en) * | 2021-04-21 | 2021-08-03 | 河南瑞珀斯生物科技有限公司 | Stem cell exosome freeze-dried powder for beauty treatment and skin care and preparation method thereof |
| CN115054572A (en) * | 2022-05-19 | 2022-09-16 | 西藏邦臣药业集团有限公司 | Vitamin C injection containing biotin and preparation method thereof |
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| CN101780100B (en) | 2011-12-21 |
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Effective date of registration: 20191204 Address after: 102200 Room 101, building 9, yard 8, Heying Road, Nanshao Town, Changping District, Beijing Patentee after: Guoren health pharmaceutical (Beijing) Co., Ltd. Address before: 100027, room 18, 1-1608 Xin Tong Street, Beijing, Dongcheng District Patentee before: Beijing Guorentang Medical Science Developing Co., Ltd. |