CN101768202B - 知母中菝葜皂苷元及其衍生物的制备方法及其医药新用途 - Google Patents
知母中菝葜皂苷元及其衍生物的制备方法及其医药新用途 Download PDFInfo
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- CN101768202B CN101768202B CN2009102585150A CN200910258515A CN101768202B CN 101768202 B CN101768202 B CN 101768202B CN 2009102585150 A CN2009102585150 A CN 2009102585150A CN 200910258515 A CN200910258515 A CN 200910258515A CN 101768202 B CN101768202 B CN 101768202B
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- 0 C[C@](C(C(C1)O2)[C@@](C)(CC3)C1C(CC1)C3[C@]3(C)C1C[C@@](*)CC3)C21OC[C@@](C)CC1 Chemical compound C[C@](C(C(C1)O2)[C@@](C)(CC3)C1C(CC1)C3[C@]3(C)C1C[C@@](*)CC3)C21OC[C@@](C)CC1 0.000 description 3
- GNCSZRRGALQUTL-JAVCKPHESA-N CCC(OC1OC[C@@H](C)CC1)=O Chemical compound CCC(OC1OC[C@@H](C)CC1)=O GNCSZRRGALQUTL-JAVCKPHESA-N 0.000 description 1
- GMBQZIIUCVWOCD-OWZFVJQDSA-N C[C@@H](C(C(C1)O2)[C@@](C)(CC3)C1C(CC1)C3[C@@](C)(CC3)C1C[C@H]3O)C21OC[C@@H](C)CC1 Chemical compound C[C@@H](C(C(C1)O2)[C@@](C)(CC3)C1C(CC1)C3[C@@](C)(CC3)C1C[C@H]3O)C21OC[C@@H](C)CC1 GMBQZIIUCVWOCD-OWZFVJQDSA-N 0.000 description 1
- HWDQYFAQNFDOBF-ZKNTXOAISA-N C[C@@H](C(C(C1)O2)[C@@](C)(CC3)C1C(CC1)C3[C@@](C)(CC3)C1C[C@H]3OC(N)=O)C21OC[C@@H](C)CC1 Chemical compound C[C@@H](C(C(C1)O2)[C@@](C)(CC3)C1C(CC1)C3[C@@](C)(CC3)C1C[C@H]3OC(N)=O)C21OC[C@@H](C)CC1 HWDQYFAQNFDOBF-ZKNTXOAISA-N 0.000 description 1
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Abstract
Description
Compd. Yield/% mp,Ms M/Z[M+H]+ 13C-NMR(300MHz,CDCl3)δ |
1a 80% 445 14.45,16.15,16.60,20.98,23.93,25.10,25.86,26.03,26.44,27.16,30.68×2,31.83,35.10,35.37,35.37,37.31,40.13,40.33,40.76.42.22,56.48,62.15,65.23,71.06,81.10,109.86,160.101b 60% 655 14.30,15.50,16.10,16.32,20.88,23.93,25.10,25.86,26.10,26.41,27.05,(29.00~29.58)×14,30.65,30.79,31.91,34.04,34.98,35.29,40.21,40.62,42.11,56.36,62.06,65.07,70.36,80.98,109.71,173.412a 45% 436 14.26,15.98,16.41,20.83,23.84,25.70,25.88,26.36,26.4927.01,27.73,29.88,31.66,33.46,36.44,36.81,39.79,40.1840.24,40.59,42.56,56.34,56.4462.03,65.06,80.91,109.652b 69% 481 14.53,16.24,16.68,21.13,24.24,25.38,25.98,26.16,26.6626.68,27.28,30.99,31.30,31.95,34.4435.34,37.88,40.2540.45,40.87,42.33,52.43,56.60,62.31,65.33,81.19,109.912c 30% 527 14.30,16.10,16.32,20.88,23.93,25.10,25.86,26.10,26.4127.05,29.36,30.65,30.79,31.91,34.04,34.98,35.29,40.1140.21,40.62,42.11,48.26,56.36,62.06,65.07,80.98,109.713 70% 497 14.91,15.98,16.41,20.83,23.84,25.70,25.88,26.36,26.4927.01,27.73,29.99,31.66,34.46,36.44,36.81,39.79,40.1840.24,40.59,42.56,56.34,62.03,65.06,75.44,80.91,109.654 40% 399 14.30,16.10,16.32,20.88,23.93,25.10,25.86,26.10,26.4127.05,30.65,30.79,31.91,34.04,34.98,35.29,40.11,40.2140.62,42.11,56.36,62.06,65.07,80.98,109.71,127.08,132.28 |
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CN2009102585150A CN101768202B (zh) | 2009-02-18 | 2009-12-12 | 知母中菝葜皂苷元及其衍生物的制备方法及其医药新用途 |
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CN200910010389.7 | 2009-02-18 | ||
CN200910010389A CN101531697A (zh) | 2009-02-18 | 2009-02-18 | 知母中菝葜皂苷元及其衍生物的制备方法及其医药新用途 |
CN2009102585150A CN101768202B (zh) | 2009-02-18 | 2009-12-12 | 知母中菝葜皂苷元及其衍生物的制备方法及其医药新用途 |
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CN101768202A CN101768202A (zh) | 2010-07-07 |
CN101768202B true CN101768202B (zh) | 2013-10-30 |
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CN2009102585150A Expired - Fee Related CN101768202B (zh) | 2009-02-18 | 2009-12-12 | 知母中菝葜皂苷元及其衍生物的制备方法及其医药新用途 |
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Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013149580A1 (en) * | 2012-04-03 | 2013-10-10 | Chiming Che | Timosaponin compounds |
CN102924559B (zh) * | 2012-11-16 | 2015-10-28 | 沈阳药科大学 | 菝葜皂苷元衍生物及其制备和应用 |
CN103349724A (zh) * | 2013-08-02 | 2013-10-16 | 石任兵 | 一种知母总黄酮提取物及其同时制备知母总黄酮提取物及总皂苷提取物的方法 |
CN105193825A (zh) * | 2015-10-18 | 2015-12-30 | 苏州普罗达生物科技有限公司 | 菝葜皂苷元3位羟基甲酰酯在制备治疗***药物中的应用 |
CN108264535A (zh) | 2016-12-30 | 2018-07-10 | 中国科学院上海药物研究所 | 一种抗抑郁化合物及其制备方法和应用 |
WO2020259612A1 (zh) * | 2019-06-26 | 2020-12-30 | 中国科学院上海药物研究所 | 一种抗抑郁甾体化合物 |
CN113831381A (zh) * | 2020-06-24 | 2021-12-24 | 中国科学院上海药物研究所 | 一种用于治疗抑郁症的甾体化合物 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1377368A (zh) * | 1999-09-29 | 2002-10-30 | 植物药物公共有限公司 | 5-β皂草苷配基和假皂草苷配基衍生物及其在治疗痴呆中的用途 |
CN1678325A (zh) * | 2001-03-28 | 2005-10-05 | 费托泰克有限公司 | 皂苷元衍生物,其合成与用途,以及采用该皂苷元衍生物的方法 |
CN1699403A (zh) * | 2005-05-24 | 2005-11-23 | 浙江大学 | 从中药材中提取菝葜皂甙元的方法 |
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2009
- 2009-12-12 CN CN2009102585150A patent/CN101768202B/zh not_active Expired - Fee Related
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1377368A (zh) * | 1999-09-29 | 2002-10-30 | 植物药物公共有限公司 | 5-β皂草苷配基和假皂草苷配基衍生物及其在治疗痴呆中的用途 |
CN1678325A (zh) * | 2001-03-28 | 2005-10-05 | 费托泰克有限公司 | 皂苷元衍生物,其合成与用途,以及采用该皂苷元衍生物的方法 |
CN1699403A (zh) * | 2005-05-24 | 2005-11-23 | 浙江大学 | 从中药材中提取菝葜皂甙元的方法 |
Non-Patent Citations (3)
Title |
---|
吴妍 等.之母提取物的提取及制剂工艺研究.《中国优秀硕士学位论文全文数据库 工程科技Ⅰ辑》.2009,(第1期),7-38页. * |
张锐 等.知母菝葜皂苷元的分离纯化以及体外又到肝癌细胞HepG2凋亡的研究.《中国优秀硕士学位论文全文数据库 医药卫生科技辑》.2006,(第10期),34-35. * |
韩丽萍 等.大孔树脂法提取知母总皂苷.《中药材》.2004,(第4期),288-289页. * |
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