CN101766727A - Traditional Chinese medicine combination for high blood pressure and preparation method thereof - Google Patents

Abstract

The invention discloses a traditional Chinese medicine combination for high blood pressure and a preparation method thereof. The medicine combination is formed with the following 14 traditional Chinese herbs as raw materials: parasitic loranthus, rehmanniae praeparatum, salivia chinensis, radix paeoniae alba, scutellaria baicalensis, chrysanthemum, selfheal, eucommia ulmoides, radix achyranthis bidentatae, ramulus mori, cassia twig, raw concha haliotidis, liquorice and astragalus mongholicus. With the functions of mediating veins, lowering the blood pressure and relieving dizziness, the traditional Chinese medicine combination in the invention can treat the following symptoms: dizziness and headache (the symptoms can be intensified due to fatigue, trouble and anger), rapid and forceful pulse condition, numbness of hands and feet when in serious condition, and the like.

Description

A kind of hypertensive Chinese medicine drug regimen and preparation method thereof that is used for

Technical field

The invention belongs to tcm field, be specifically related to a kind of hypertensive Chinese medicine drug regimen and preparation method thereof that is used for.

Background technology

Change along with growth in the living standard and rhythm of life is called as the hypertension of " affluenza ", and as " the old times king thanks to a preceding swallow, flies into common people house ", the cardiovascular and cerebrovascular disease M ﹠ M that causes because of hypertension rises year by year.

China have at least 8,500 ten thousand late period the hypertensive patient, wherein about 60% patient's blood pressure is in the scope of 140-160/90-95mmHg.Long-range target is to allow all hypertensive patients all obtain the ideal treatment of equal quality.

Preparation of the present invention is used for the treatment of benign hypertension, benign hypertension also claims benign hypertension, the onset concealment, the course of disease is made slow progress, and nearly half patient can be asymptomatic, and blood pressure increases the physical examination or just must find when seeking medical advice because of other disease of being everlasting, a few patients is then found when suddenly cerebrovascular accident taking place, this shows primary disease and excessive rising of liver-YANG, inverse relationship on the vim and vigour, promptly directly related with " blood vessels ".This prescription mediation venation makes the blood vessels coordinated balance, and the clear dizzy blood pressure that makes of blood pressure lowering is steady, and the head is clear-headed.Radix Achyranthis Bidentatae the liver and the kidney tonifying in the side, conducting blood to flow downwards; The contrary YANG hyperactivity suppressing in Concha Haliotidis town; Parasitic, Cortex Eucommiae the liver and the kidney tonifying; The Radix Rehmanniae is contrary with flat blood; Cortex Moutan, Radix Paeoniae Alba removing heat from blood and promoting blood circulation, hemopoietic and arteries and veins; The Radix Scutellariae replenishing YIN and removing heat; Flos Chrysanthemi is controlled the vertigo; Spica Prunellae tonifying liver blood removes fidgets due to deficiency; Ramulus Mori, Ramulus Cinnamomi transfer battalion to promote blood circulation, in case hemiplegia; Radix Astragali tonifying Qi and lifting yang; The Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.All medicines share, and invigorating the liver and kidney is arranged, the suppressing the hyperactive liver sun, and it is contrary to fall blood, and the effect of blood circulation regulating makes YIN and YANG in a relative equilibrium, and blood vessels are in harmonious proportion, and are applicable to benign hypertension.

Summary of the invention

The invention provides a kind of hypertensive Chinese medicine drug regimen and preparation method thereof that is used for, purpose is to select for extensive patients provides new medication, makes things convenient for patient treatment.

The present invention is achieved by the following technical solutions:

A kind ofly be used for hypertensive Chinese medicine drug regimen, it is that raw material is made by following parts by weight of Chinese traditional medicine material:

5～35 parts of 5～35 portions of Radix Paeoniae Albas of 5～35 parts of Cortex Moutans of 5～35 parts of Radix Rehmanniae of Herba Taxilli

5～35 parts of 15～60 parts of Cortexs Eucommiae of 5～45 parts of Spica Prunellaes of 4～40 parts of Flos Chrysanthemis of Radix Scutellariae

10～45 parts of 4～45 parts of Concha Haliotidiss of 6～40 parts of Ramulus Cinnamomi of 5～35 parts of Ramulus Moris of Radix Achyranthis Bidentatae

10～45 parts of 5～35 parts of Radixs Astragali of Radix Glycyrrhizae

And the weight portion proportioning of described each Chinese crude drug raw material is:

15 parts of 15 portions of Radix Paeoniae Albas of 15 parts of Cortex Moutans of 15 parts of Radix Rehmanniae of Herba Taxilli

15 parts of 30 parts of Cortexs Eucommiae of 15 parts of Spica Prunellaes of 15 parts of Flos Chrysanthemis of Radix Scutellariae

30 parts of 15 parts of Concha Haliotidiss of 15 parts of Ramulus Cinnamomi of 15 parts of Ramulus Moris of Radix Achyranthis Bidentatae

25 parts of 15 parts of stilbenes of Radix Glycyrrhizae

Described preparation is a capsule.

Described adjuvant includes but not limited to one or more in starch, dextrin, lactose, the soluble starch.

The preparation method of this drug regimen is:

(1) get above-mentioned prescription Chinese crude drug and suitably be ground into coarse powder, decoct with water 2～5 times, each 6～10 times of amounts 1～3 hour filter, and collecting decoction is concentrated into the thick paste of relative density 1.05～1.30 (30～85 ℃);

(2) with above-mentioned steps (1) gained thick paste, drying is pulverized, and adds appropriate amount of auxiliary materials, sieves, and granulates, and makes capsule, promptly.

For beneficial effect of the present invention better is described, we have carried out following experimental study:

Adopt following principal agent for square substantially:

Herba Taxilli 15g Radix Rehmanniae 15g Cortex Moutan 15g Radix Paeoniae Alba 15g

Radix Scutellariae 15g Flos Chrysanthemi 15g Spica Prunellae 30g Cortex Eucommiae 15g

Radix Achyranthis Bidentatae 15g Ramulus Mori 15g Ramulus Cinnamomi 15g Concha Haliotidis 30g

Radix Glycyrrhizae 15g Radix Astragali 25g

One, clinical observation

1 case is selected

Totally 30 routine hyperpietics, male 17 examples, women 13 examples, 37～71 years old age, average (51.9 ± 15) year.Selected patient meets WHO/ISH, Evaluation of Diagnostic Criteria of Hypertension.Being divided into is 3 groups, and the 1st group produces untoward reaction and need drug withdrawal for taking original antihypertensive drugs, uses preparation person of the present invention instead; The 2nd group is original antihypertensive drugs poor effect (BP 〉=140/90mmHg) directly add with preparation person of the present invention; The 3rd group is that essential hypertension is not used any depressor person.

2 administrated methods

3 groups of patients all use preparation 4mg of the present invention, and qd is an initial dose, and escalated dose is to 8mg, qd gradually.Per 2 weeks are surveyed the seat blood pressure 3 times, calculating mean value.The 4th all mean blood pressures 〉=140/90mmHg person adds with hydrochlorothiazide (Zhenjiang Ji Bei pharmaceutcal corporation, Ltd, lot number 990102) 12.5mg, qd.

3 statistical method

3.1 clinical efficacy

After the 1st group of patient uses preparation of the present invention instead, the flushed face that 3 examples occur with calcium antagonist, feeling of fullness in the head, ankle edema disappear, the weakness of the lower extremities that 1 example occurs with beta-blocker is numb to disappear, show preparation well-tolerated of the present invention and antihypertensive effect is similar or better to former medicine, seeing Table 1 the 2nd group of patient has 3 examples to use hydrochlorothiazide 12.5mg because of 4 blood pressure 〉=140/90mmHg when all add, qd, 6 whens week patient's blood pressure of totally 58.3% reduce to normally.The 3rd group of patient during 6 weeks blood pressure all reduce to normally.All patients all antihypertensive effect occurs when 2 weeks, occur the maximum reducing effect during 4～6 weeks.

Table 13 group take preparation 6 all blood pressure of the present invention (x ± s, mmHg)

4 discuss

Preparation of the present invention does not reach adding with preparation of the present invention of promising result for other antihypertensive drugs and can obviously bring high blood pressure down, and can be used as initial antihypertensive drugs to just sending out hypertension.There is 68.8% patient to accept preparation for treating bleeding from anus of the present invention pressure drop in this research to normal, the basic blood pressure that does not reach normal person all 〉=160/90mmHg, be up to 190/110mmHg, though obvious decline of blood pressure do not reach normal level yet through the coupling hydrochlorothiazide after the medication, point out preparation of the present invention can reduce to normally light moderate hypertension, the centering severe hypertension needs coupling hydrochlorothiazide and other antihypertensive drugs.

The specific embodiment

Embodiment 1: medicament composition capsule agent of the present invention

Herba Taxilli 15g Radix Rehmanniae 15g Cortex Moutan 15g Radix Paeoniae Alba 15g

Radix Scutellariae 15g Flos Chrysanthemi 15g Spica Prunellae 30g Cortex Eucommiae 15g

Radix Achyranthis Bidentatae 15g Ramulus Mori 15g Ramulus Cinnamomi 15g Concha Haliotidis 30g

Radix Glycyrrhizae 15g Radix Astragali 25g

(1) get above-mentioned prescription Chinese crude drug and suitably be ground into coarse powder, decoct with water 3 times, each 10 times of amounts 2 hours filter, and collecting decoction is concentrated into the thick paste of relative density 1.20 (60 ℃);

(2) with above-mentioned steps (1) gained thick paste, drying is pulverized, and adds 12g starch, sieves, and granulates, and makes 100 capsules, promptly.

Embodiment 2: medicament composition capsule agent of the present invention

Herba Taxilli 13g Radix Rehmanniae 12g Cortex Moutan 15g Radix Paeoniae Alba 17g

Radix Scutellariae 20g Flos Chrysanthemi 22g Spica Prunellae 30g Cortex Eucommiae 21g

Radix Achyranthis Bidentatae 25g Ramulus Mori 29g Ramulus Cinnamomi 17g Concha Haliotidis 20g

Radix Glycyrrhizae 15g Radix Astragali 30g

(1) get above-mentioned prescription Chinese crude drug and suitably be ground into coarse powder, decoct with water 2 times, each 9 times of amounts 2 hours filter, and collecting decoction is concentrated into the thick paste of relative density 1.25 (45 ℃);

(2) with above-mentioned steps (1) gained thick paste, drying is pulverized, and adds the 20g dextrin, sieves, and granulates, and makes 120 capsules, promptly.

Embodiment 3: medicament composition capsule agent of the present invention

Herba Taxilli 25g Radix Rehmanniae 7g Cortex Moutan 9g Radix Paeoniae Alba 12g

Radix Scutellariae 9g Flos Chrysanthemi 10g Spica Prunellae 17g Cortex Eucommiae 9g

Radix Achyranthis Bidentatae 8g Ramulus Mori 10g Ramulus Cinnamomi 10g Concha Haliotidis 15g

Radix Glycyrrhizae 7g Radix Astragali 15g

(1) get above-mentioned prescription Chinese crude drug and suitably be ground into coarse powder, decoct with water 2 times, each 10 times of amounts 1 hour filter, and collecting decoction is concentrated into the thick paste of relative density 1.20 (55 ℃);

(2) with above-mentioned steps (1) gained thick paste, drying is pulverized, and adds 10g starch, sieves, and granulates, and makes 70 capsules, promptly.

Claims (3)

1. one kind is used for hypertensive Chinese medicine drug regimen, it is characterized in that it is made up of by the raw material of Chinese medicine of part following unit of weight:

5～35 parts of 5～35 portions of Radix Paeoniae Albas of 5～35 parts of Cortex Moutans of 5～35 parts of Radix Rehmanniae of Herba Taxilli

5～35 parts of 15～60 parts of Cortexs Eucommiae of 5～45 parts of Spica Prunellaes of 4～40 parts of Flos Chrysanthemis of Radix Scutellariae

10～45 parts of 4～45 parts of Concha Haliotidiss of 6～40 parts of Ramulus Cinnamomi of 5～35 parts of Ramulus Moris of Radix Achyranthis Bidentatae

10～45 parts of 5～35 parts of Radixs Astragali of Radix Glycyrrhizae.

2. a kind of hypertensive Chinese medicine drug regimen that is used for according to claim 1 is characterized in that it is made up of by the raw material of Chinese medicine of part following unit of weight:

15 parts of 15 portions of Radix Paeoniae Albas of 15 parts of Cortex Moutans of 15 parts of Radix Rehmanniae of Herba Taxilli

15 parts of 30 parts of Cortexs Eucommiae of 15 parts of Spica Prunellaes of 15 parts of Flos Chrysanthemis of Radix Scutellariae

30 parts of 15 parts of Concha Haliotidiss of 15 parts of Ramulus Cinnamomi of 15 parts of Ramulus Moris of Radix Achyranthis Bidentatae

25 parts of 15 parts of Radixs Astragali of Radix Glycyrrhizae.

3. according to each described a kind of hypertensive Chinese medicine drug regimen that is used for of claim 1-2, its preparation method is:

(1) get above-mentioned prescription Chinese crude drug and suitably be ground into coarse powder, decoct with water 2～5 times, each 6～10 times of amounts 1～3 hour filter, and collecting decoction is concentrated into the thick paste of relative density 1.05～1.30 (30～85 ℃);

(2) with above-mentioned steps (1) gained thick paste, drying is pulverized, and adds appropriate amount of auxiliary materials, sieves, and granulates, and makes capsule, promptly.